| Enriched cancer pathway | Genes under regulation | P value |
|---|
| Focal adhesion |
24 genes: AKT3, COL3A1, COL5A2, RAPGEF1, HGF, ILK, ITGA1, ITGAV, ARHGAP5, SHC4, MYLK, PDGFRA, PIK3CG, PIK3R1, PARVA, PRKCB, PDGFC, PTEN, RAP1A, BCL2, THBS1, PDGFD, ITGA8, CAV2
|
2.711e-07 |
| PI3K AKT signaling pathway |
32 genes: FGF2, FGF5, PDGFC, PDGFD, KITLG, HGF, ANGPT1, FGFR1, NTRK2, PDGFRA, IL7, IL7R, COL4A3, THBS1, ITGA1, ITGA8, ITGAV, PIK3R1, F2R, CHRM2, LPAR1, GNG2, PIK3CG, PRKAA2, AKT3, PTEN, PHLPP2, CDK6, FOXO3, BCL2, CREB5, MCL1
|
1.699e-06 |
| Regulation of actin cytoskeleton |
23 genes: CFL2, IQGAP2, CHRM2, CHRM3, DIAPH2, F2R, FGF2, FGF5, FGFR1, MRAS, GNA12, NCKAP1L, APC, ITGA1, ITGAV, MYLK, PDGFRA, PIK3CG, PIK3R1, PIP4K2A, PDGFC, PDGFD, ITGA8
|
3.285e-06 |
| Calcium signaling pathway |
19 genes: CYSLTR1, CHRM2, CHRM3, F2R, GNAQ, GRIN2A, HRH1, ITPR1, ITPR2, MYLK, PDE1C, PDGFRA, PLN, PPP3CA, PRKCB, PTGER3, RYR2, TRPC1, CAMK4
|
2.344e-05 |
| Ras signaling pathway |
22 genes: FGF2, FGF5, PDGFC, PDGFD, KITLG, HGF, ANGPT1, FGFR1, NTRK2, PDGFRA, GAB1, SHC4, GNG2, GRIN2A, MRAS, PIK3R1, AKT3, ETS1, RAPGEF5, RAP1A, RGL1, PRKCB
|
4.976e-05 |
| Neurotrophin signaling pathway |
14 genes: AKT3, IRAK3, FOXO3, GAB1, RAPGEF1, SHC4, NTRK2, NTRK3, PIK3CG, PIK3R1, RAP1A, BCL2, CAMK4, RPS6KA5
|
0.0002044 |
| Osteoclast differentiation |
14 genes: AKT3, LILRB2, CYBB, FOS, IL1R1, LCP2, MITF, NFATC2, PIK3CG, PIK3R1, PPP3CA, TGFB2, TGFBR2, CAMK4
|
0.0002221 |
| MAPK signaling pathway |
22 genes: AKT3, MAP3K2, FGF2, FGF5, FGFR1, MRAS, FOS, GNA12, IL1R1, MEF2C, NFATC2, NTRK2, PDGFRA, PPP3CA, PRKCB, RAP1A, TGFB2, TGFBR2, CACNA2D1, CACNB4, RPS6KA5, CACNA2D4
|
0.0003137 |
| Gap junction |
11 genes: MAP3K2, LPAR1, GNAQ, ITPR1, ITPR2, PDGFRA, PRKCB, PRKG1, PDGFC, TUBA1A, PDGFD
|
0.0003957 |
| Cell adhesion molecules .CAMs. |
14 genes: CNTN1, ALCAM, NLGN1, CADM1, NEGR1, ITGAV, NCAM1, NCAM2, PTPRC, JAM2, SDC2, SPN, ITGA8, NRXN1
|
0.0004166 |
| Phosphatidylinositol signaling system |
10 genes: DGKB, DGKG, ITPR1, ITPR2, PIK3CG, PIK3R1, PIP4K2A, PRKCB, PTEN, DGKI
|
0.0004899 |
| Circadian rhythm . mammal |
5 genes: FBXL3, RORA, BHLHE40, PER3, CLOCK
|
0.001191 |
| Apoptosis |
10 genes: AKT3, IRAK3, IL1R1, IL1RAP, ATM, PIK3CG, PIK3R1, PPP3CA, PRKAR2B, BCL2
|
0.001388 |
| Long.term potentiation |
8 genes: GNAQ, GRIN2A, ITPR1, ITPR2, PPP3CA, PRKCB, RAP1A, CAMK4
|
0.003672 |
| Carbohydrate digestion and absorption |
6 genes: AKT3, ATP1A2, PIK3CG, PIK3R1, PRKCB, SLC2A5
|
0.004785 |
| Nicotinate and nicotinamide metabolism |
4 genes: NAMPT, NMNAT2, AOX1, NT5E
|
0.01011 |
| Hippo signaling pathway |
12 genes: YAP1, WWTR1, FRMD6, DLG2, TEAD1, TGFB2, TGFBR2, BMP2, BMPR2, FZD7, APC, SNAI2
|
0.01022 |
| Jak.STAT signaling pathway |
12 genes: AKT3, IL22RA2, SPRED1, IL6ST, IL7, IL7R, LEPR, LIFR, PIK3CG, PIK3R1, STAT5B, TPO
|
0.01072 |
| Pancreatic secretion |
9 genes: CHRM3, GNAQ, ITPR1, ITPR2, ATP1A2, PRKCB, RAP1A, RYR2, TRPC1
|
0.0109 |
| TGF.beta signaling pathway |
8 genes: CDKN2B, INHBA, SMAD9, BMP2, BMPR2, TGFB2, TGFBR2, THBS1
|
0.01171 |
| Hematopoietic cell lineage |
8 genes: IL1R1, IL7, IL7R, ITGA1, KITLG, TPO, MS4A1, CD59
|
0.01424 |
| Aldosterone.regulated sodium reabsorption |
5 genes: NR3C2, ATP1A2, PIK3CG, PIK3R1, PRKCB
|
0.01716 |
| Gastric acid secretion |
7 genes: CHRM3, GNAQ, ITPR1, ITPR2, MYLK, ATP1A2, PRKCB
|
0.01738 |
| B cell receptor signaling pathway |
7 genes: AKT3, FOS, NFATC2, PIK3CG, PIK3R1, PPP3CA, PRKCB
|
0.01859 |
| Axon guidance |
10 genes: SEMA3A, CFL2, EPHB1, NTNG1, NFATC2, PPP3CA, SEMA3G, SLIT3, SEMA6D, UNC5C
|
0.01965 |
| Chemokine signaling pathway |
13 genes: AKT3, CCR6, FOXO3, SHC4, CXCL9, PIK3CG, PIK3R1, GNG2, PRKCB, RAP1A, CCL11, STAT5B, ELMO1
|
0.02014 |
| Natural killer cell mediated cytotoxicity |
10 genes: KLRC1, KLRC2, LCP2, SHC4, SH2D1A, NFATC2, PIK3CG, PIK3R1, PPP3CA, PRKCB
|
0.02595 |
| Insulin signaling pathway |
10 genes: AKT3, PPARGC1A, RAPGEF1, SHC4, PDE3A, PIK3CG, PIK3R1, PRKAA2, PRKAR2B, PPP1R3B
|
0.02833 |
| Toll.like receptor signaling pathway |
8 genes: AKT3, TLR6, FOS, CXCL9, PIK3CG, PIK3R1, TLR5, TRAF3
|
0.03151 |
| Glycerolipid metabolism |
5 genes: MBOAT2, DGKB, DGKG, AGPAT4, DGKI
|
0.03383 |
| ECM.receptor interaction |
7 genes: COL3A1, COL5A2, ITGA1, ITGAV, SDC2, THBS1, ITGA8
|
0.0341 |
| Adipocytokine signaling pathway |
6 genes: AKT3, PPARGC1A, ACSL4, LEPR, PPARA, PRKAA2
|
0.03605 |
| ErbB signaling pathway |
7 genes: AKT3, GAB1, SHC4, PIK3CG, PIK3R1, PRKCB, STAT5B
|
0.03799 |
| mTOR signaling pathway |
5 genes: AKT3, CAB39, PIK3CG, PIK3R1, PRKAA2
|
0.03916 |
| Long.term depression |
6 genes: GNA12, GNAQ, ITPR1, ITPR2, PRKCB, PRKG1
|
0.04069 |
| T cell receptor signaling pathway |
8 genes: AKT3, FOS, LCP2, NFATC2, PIK3CG, PIK3R1, PPP3CA, PTPRC
|
0.04206 |
| Salivary secretion |
7 genes: CHRM3, GNAQ, ITPR1, ITPR2, ATP1A2, PRKCB, PRKG1
|
0.04217 |
| Nitrogen metabolism |
3 genes: CA5B, GLS, CA12
|
0.04868 |