| Enriched cancer pathway | Genes under regulation | P value |
|---|
| Calcium signaling pathway |
13 genes: PLCD3, CHRM3, SLC25A4, HRH2, ITPR2, ATP2A2, PDGFRA, PPP3CB, PRKACB, PRKCA, RYR2, TACR1, PLCD4
|
0.000206 |
| Gastric acid secretion |
8 genes: CHRM3, GNAI2, HRH2, ITPR2, KCNQ1, ATP1B2, PRKACB, PRKCA
|
0.0002653 |
| Ras signaling pathway |
15 genes: BDNF, IGF2, NTRK2, IGF1R, PDGFRA, CSF1R, FLT1, SOS1, PRKACB, RASAL2, RASSF5, FOXO4, PLA2G5, RGL1, PRKCA
|
0.0003353 |
| Pancreatic secretion |
9 genes: CHRM3, ITPR2, KCNMA1, KCNQ1, ATP1B2, ATP2A2, PLA2G5, PRKCA, RYR2
|
0.0004803 |
| Osteoclast differentiation |
10 genes: CSF1R, CTSK, FCGR2B, FHL2, FOSL2, PPP3CB, SPI1, TGFBR1, SQSTM1, SOCS3
|
0.0006762 |
| Gap junction |
8 genes: LPAR1, GNAI2, ITPR2, PDGFRA, PRKACB, PRKCA, SOS1, TUBA1A
|
0.0009969 |
| Cardiac muscle contraction |
7 genes: ATP1B2, ATP2A2, RYR2, TPM2, TPM4, CACNB2, COX4I2
|
0.001794 |
| Phosphatidylinositol signaling system |
7 genes: PLCD3, PIP5K1C, INPP5A, ITPR2, PIP4K2A, PRKCA, PLCD4
|
0.001933 |
| Axon guidance |
9 genes: EPHB1, UNC5B, GNAI2, NFATC3, PLXNB3, SEMA4C, PPP3CB, ABLIM2, UNC5C
|
0.002855 |
| Salivary secretion |
7 genes: CHRM3, ITPR2, KCNMA1, ATP1B2, PRKACB, PRKCA, VAMP2
|
0.00408 |
| Long.term potentiation |
6 genes: RAPGEF3, EP300, ITPR2, PPP3CB, PRKACB, PRKCA
|
0.005046 |
| Long.term depression |
6 genes: GNAI2, GNAO1, IGF1R, ITPR2, PLA2G5, PRKCA
|
0.005046 |
| Adherens junction |
6 genes: SORBS1, EP300, IGF1R, PTPRB, TGFBR1, ACTN4
|
0.006192 |
| PI3K AKT signaling pathway |
16 genes: BDNF, IGF2, NTRK2, IGF1R, PDGFRA, CSF1R, FLT1, SOS1, IL4R, LAMB1, ITGA4, ITGA7, LPAR1, EIF4B, PRKCA, PPP2R2C
|
0.00662 |
| MAPK signaling pathway |
13 genes: HSPA2, NTRK2, PDGFRA, PLA2G5, PPP3CB, PRKACB, PRKCA, MAP2K3, BDNF, SOS1, TGFBR1, CACNB2, RAPGEF2
|
0.0084 |
| Inositol phosphate metabolism |
5 genes: PLCD3, PIP5K1C, INPP5A, PIP4K2A, PLCD4
|
0.009292 |
| Tight junction |
8 genes: EPB41L2, GNAI2, PPP2R2C, PRKCA, ASH1L, ACTN4, TJP2, MAGI2
|
0.01092 |
| Cell adhesion molecules .CAMs. |
8 genes: NFASC, ITGA4, NCAM2, NLGN3, CADM3, CNTN2, NRXN3, NRXN1
|
0.01238 |
| Hematopoietic cell lineage |
6 genes: CR1, CSF1R, IL4R, ITGA4, CD1E, CD33
|
0.01488 |
| Focal adhesion |
10 genes: FLT1, PIP5K1C, IGF1R, ITGA4, ITGA7, LAMB1, PDGFRA, PRKCA, SOS1, ACTN4
|
0.01609 |
| Endocytosis |
10 genes: CSF1R, DAB2, EPN2, FLT1, PIP5K1C, HSPA2, IGF1R, PDGFRA, TGFBR1, USP8
|
0.01766 |
| Wnt signaling pathway |
8 genes: EP300, DAAM2, NFATC3, PPP3CB, PRKACB, PRKCA, SFRP5, WNT5B
|
0.02188 |
| GnRH signaling pathway |
6 genes: ITPR2, PLA2G5, PRKACB, PRKCA, MAP2K3, SOS1
|
0.02733 |
| Melanogenesis |
6 genes: EP300, GNAI2, GNAO1, PRKACB, PRKCA, WNT5B
|
0.02733 |
| TGF.beta signaling pathway |
5 genes: EP300, ID4, GDF6, LEFTY2, TGFBR1
|
0.04382 |