Enriched cancer pathway | Genes under regulation | P value |
MAPK signaling pathway |
33 genes: DUSP10, MAPK14, DUSP3, FGF1, FGF2, FGF5, FGF7, FGFR1, RRAS2, FOS, NR4A1, FAS, IL1R1, ARRB1, MAX, NTRK2, TAOK3, PLA2G2A, PLA2G4A, PLA2G5, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKCB, MAPK9, BDNF, TGFB2, TGFBR1, TNF, CACNB2, CACNB4, MAP4K4
|
1.248e-08 |
Ras signaling pathway |
28 genes: FGF1, FGF2, FGF7, FGF5, BDNF, IGF1, PDGFC, ANGPT1, FGFR1, NTRK2, GAB1, SHC4, GNB4, GNB5, PRKACB, GRIN2A, RRAS2, RASAL2, RHOA, SHOC2, PLA2G5, PLA2G2A, PLA2G4A, RGL1, MAPK9, PRKCB, ABL1, ABL2
|
3.425e-07 |
Apoptosis |
14 genes: IRAK3, ENDOD1, FAS, IL1R1, IL1RAP, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKAR2A, PRKAR2B, TNF, TNFSF10, TNFRSF10C
|
1.244e-05 |
PI3K AKT signaling pathway |
32 genes: FGF1, FGF2, FGF7, FGF5, BDNF, IGF1, PDGFC, ANGPT1, FGFR1, NTRK2, IL6, GHR, CSF3R, COL4A4, LAMC1, RELN, ITGA1, ITGAV, ITGB5, ITGB8, F2R, LPAR1, GNB4, GNB5, SGK1, PPP2CB, PPP2R3C, YWHAH, CREB3L2, CREB5, MCL1, NR4A1
|
1.617e-05 |
Vascular smooth muscle contraction |
16 genes: CALCRL, ADCY2, ADCY9, EDNRA, GUCY1B3, ITPR2, RHOA, NPR2, PLA2G2A, PLA2G4A, PLA2G5, PLCB4, PRKACB, PRKCB, PRKG1, CALD1
|
1.703e-05 |
Long.term depression |
12 genes: GNAZ, GRIA3, GUCY1B3, IGF1, ITPR2, PLA2G2A, PLA2G4A, PLA2G5, PLCB4, PPP2CB, PRKCB, PRKG1
|
2.119e-05 |
Osteoclast differentiation |
15 genes: LILRB4, MAPK14, CYBB, FOS, IL1R1, NCF4, TREM2, PPP3CA, PPP3CB, PPP3CC, MAPK9, STAT1, TGFB2, TGFBR1, TNF
|
0.0002043 |
Calcium signaling pathway |
18 genes: ADCY2, ADCY9, EDNRA, EDNRB, F2R, GRIN2A, ITPR2, P2RX7, PDE1C, PDE1B, PLCB4, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKCB, RYR2, SLC8A1
|
0.000302 |
Regulation of actin cytoskeleton |
20 genes: CFL2, NCKAP1, F2R, FGF1, FGF2, FGF5, FGF7, FGFR1, RRAS2, TIAM2, ITGA1, ITGAV, ITGB5, ITGB8, RHOA, MYH9, PDGFC, ACTN4, IQGAP1, ARHGEF6
|
0.0004381 |
Gap junction |
11 genes: ADCY2, ADCY9, LPAR1, GUCY1B3, ITPR2, PLCB4, PRKACB, PRKCB, PRKG1, PDGFC, TUBA1A
|
0.0009821 |
Wnt signaling pathway |
15 genes: PRICKLE1, PRICKLE2, DKK2, RHOA, PLCB4, PPP2CB, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKCB, MAPK9, WNT7A, FZD4, NKD1
|
0.001186 |
Phagosome |
15 genes: CYBB, HLA-DPA1, HLA-DQA1, HLA-DQA2, ITGAV, ITGB5, MSR1, NCF4, ATP6V1E1, CLEC7A, TAP1, TUBA1A, STX7, VAMP3, CD36
|
0.001646 |
Circadian rhythm . mammal |
5 genes: FBXL3, ARNTL, RORA, RORB, PER3
|
0.001939 |
ECM.receptor interaction |
10 genes: COL4A4, COL11A1, ITGA1, ITGAV, ITGB5, ITGB8, LAMC1, RELN, CD36, SV2B
|
0.002199 |
GnRH signaling pathway |
11 genes: ADCY2, ADCY9, MAPK14, ITPR2, PLA2G2A, PLA2G4A, PLA2G5, PLCB4, PRKACB, PRKCB, MAPK9
|
0.002517 |
Hematopoietic cell lineage |
10 genes: CR1, CSF2RA, CSF3R, IL1R1, IL6, ITGA1, MME, TNF, MS4A1, CD36
|
0.002848 |
Gastric acid secretion |
9 genes: ADCY2, ADCY9, ITPR2, KCNJ2, KCNJ10, KCNJ16, PLCB4, PRKACB, PRKCB
|
0.002867 |
Focal adhesion |
17 genes: COL4A4, COL11A1, IGF1, ITGA1, ITGAV, ITGB5, ITGB8, RHOA, LAMC1, SHC4, PRKCB, MAPK9, PDGFC, RELN, ACTN4, CAV1, CAV2
|
0.003144 |
Chemokine signaling pathway |
16 genes: GNB5, ADCY2, ADCY9, CCR6, CX3CR1, TIAM2, RHOA, SHC4, ARRB1, PLCB4, PRKACB, PRKCB, PREX1, GNB4, CXCL6, STAT1
|
0.004261 |
Neurotrophin signaling pathway |
12 genes: IRAK3, MAPK14, ABL1, GAB1, RHOA, SHC4, NTRK2, NTRK3, MAPK9, BDNF, YWHAH, IRS2
|
0.005311 |
Long.term potentiation |
8 genes: GRIN2A, ITPR2, PLCB4, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKCB
|
0.007042 |
Pancreatic secretion |
10 genes: ADCY2, ADCY9, ITPR2, RHOA, PLA2G2A, PLA2G4A, PLA2G5, PLCB4, PRKCB, RYR2
|
0.007611 |
Adherens junction |
8 genes: SORBS1, FER, FGFR1, RHOA, PTPRB, TGFBR1, ACTN4, IQGAP1
|
0.009028 |
Natural killer cell mediated cytotoxicity |
12 genes: FAS, KLRC2, SHC4, SH2D1A, PPP3CA, PPP3CB, PPP3CC, PRKCB, TNF, TNFSF10, TNFRSF10C, CD48
|
0.009043 |
Lysosome |
11 genes: AP4S1, AP3S1, TPP1, CLN5, CTSO, GM2A, IDS, LIPA, ARSB, AP3B1, AP1S2
|
0.009834 |
VEGF signaling pathway |
8 genes: MAPK14, PLA2G2A, PLA2G4A, PLA2G5, PPP3CA, PPP3CB, PPP3CC, PRKCB
|
0.01141 |
Intestinal immune network for IgA production |
6 genes: HLA-DPA1, HLA-DQA1, HLA-DQA2, IL6, IL10, CD40
|
0.01352 |
Ether lipid metabolism |
5 genes: PAFAH1B1, PLA2G2A, PLA2G4A, PLA2G5, AGPS
|
0.01412 |
Purine metabolism |
13 genes: ADCY2, ADCY9, GUCY1B3, NPR2, PDE1C, PDE3A, PDE3B, PDE4B, PDE4D, PDE6D, PDE1B, PDE5A, PAPSS2
|
0.01431 |
Axon guidance |
11 genes: CFL2, EPHA7, EPHB1, NTNG1, ABL1, EPHA6, RHOA, PPP3CA, PPP3CB, PPP3CC, NRP1
|
0.01622 |
Oocyte meiosis |
10 genes: ADCY2, ADCY9, IGF1, ITPR2, PPP2CB, PPP3CA, PPP3CB, PPP3CC, PRKACB, YWHAH
|
0.01698 |
Adipocytokine signaling pathway |
7 genes: CPT1A, ACACB, LEP, MAPK9, TNF, IRS2, CD36
|
0.0195 |
Melanogenesis |
9 genes: ADCY2, ADCY9, EDNRB, PLCB4, PRKACB, PRKCB, CREB3L2, WNT7A, FZD4
|
0.02086 |
Hippo signaling pathway |
12 genes: YAP1, PPP2CB, LATS2, DLG2, FGF1, TGFB2, TGFBR1, BMPR2, WNT7A, FZD4, YWHAH, NKD1
|
0.02232 |
Jak.STAT signaling pathway |
12 genes: IL24, CISH, CSF2RA, CSF3R, SPRED1, GHR, IL6, IL6ST, IL10, IL13RA1, LEP, STAT1
|
0.02334 |
Progesterone.mediated oocyte maturation |
8 genes: ADCY2, ADCY9, MAPK14, IGF1, PDE3A, PDE3B, PRKACB, MAPK9
|
0.02412 |
Salivary secretion |
8 genes: ADCY2, ADCY9, GUCY1B3, ITPR2, PLCB4, PRKACB, PRKCB, PRKG1
|
0.0272 |
Renin.angiotensin system |
3 genes: ENPEP, LNPEP, MME
|
0.02917 |
T cell receptor signaling pathway |
9 genes: MAPK14, FOS, IL10, RHOA, PPP3CA, PPP3CB, PPP3CC, MAPK9, TNF
|
0.03059 |
Vasopressin.regulated water reabsorption |
5 genes: ADCY9, DCTN1, PRKACB, CREB3L2, CREB5
|
0.0313 |
Linoleic acid metabolism |
4 genes: PLA2G2A, PLA2G4A, PLA2G5, AKR1B10
|
0.03134 |
Fat digestion and absorption |
5 genes: ABCA1, PLA2G2A, PLA2G4A, PLA2G5, CD36
|
0.03702 |
Antigen processing and presentation |
7 genes: HLA-DPA1, HLA-DQA1, HLA-DQA2, KLRC2, B2M, TAP1, TNF
|
0.0378 |
Fc epsilon RI signaling pathway |
7 genes: MAPK14, PLA2G2A, PLA2G4A, PLA2G5, PRKCB, MAPK9, TNF
|
0.0401 |
alpha.Linolenic acid metabolism |
3 genes: PLA2G2A, PLA2G4A, PLA2G5
|
0.04474 |
Cell adhesion molecules .CAMs. |
10 genes: CDH2, NLGN1, HLA-DPA1, HLA-DQA1, HLA-DQA2, ITGAV, ITGB8, MPZ, CLDN11, CD40
|
0.04885 |