| Enriched cancer pathway | Genes under regulation | P value |
|---|
| PI3K AKT signaling pathway |
41 genes: FGF7, FGF13, FGF14, FGF18, NTF3, IGF1, PDGFA, PDGFB, PDGFC, PGF, HGF, NTRK2, IGF1R, PDGFRA, PDGFRB, KIT, TEK, IRS1, TLR4, SYK, PIK3AP1, GHR, IL2RB, IL2RG, IL6R, JAK1, JAK3, RELN, THBS1, ITGA1, ITGA11, ITGB5, PIK3CD, LPAR1, PIK3CG, AKT3, PTEN, PPP2CB, CDK6, CCND3, FOXO3
|
7.641e-09 |
| Focal adhesion |
28 genes: AKT3, MYL12A, COL3A1, COL11A1, ITGA11, HGF, IGF1, IGF1R, ITGA1, ITGB5, PDGFA, PDGFB, PDGFRA, PDGFRB, PGF, PIK3CD, PIK3CG, PDGFC, RELN, PTEN, RAP1A, THBS1, ACTN4, CAPN2, CAV1, ACTN1, ACTN2, CCND3
|
4.117e-08 |
| Jak.STAT signaling pathway |
23 genes: AKT3, SPRY1, IL22RA2, CLCF1, GHR, IL2RB, IL2RG, IL6R, IL6ST, IL10, IL10RA, IL13RA1, IL15, JAK1, JAK3, LEPR, LIF, IL21R, PIK3CD, PIK3CG, STAT4, STAT5A, CCND3
|
2.279e-07 |
| Ras signaling pathway |
26 genes: FGF7, FGF13, FGF14, FGF18, NTF3, IGF1, PDGFA, PDGFB, PDGFC, PGF, HGF, NTRK2, IGF1R, PDGFRA, PDGFRB, KIT, TEK, RASGRF2, RASA3, RASSF5, PIK3CD, AKT3, SHOC2, ETS1, RAP1A, PLD1
|
1.21e-05 |
| Regulation of actin cytoskeleton |
23 genes: MYL12A, CFL2, FGF7, FGF13, FGF14, ITGA11, ITGA1, ITGAL, ITGB5, PDGFA, PDGFB, PDGFRA, PDGFRB, PIK3CD, PIK3CG, PIP4K2A, SSH1, PDGFC, ACTN4, ACTN1, ACTN2, FGF18, IQGAP1
|
5.58e-05 |
| Gap junction |
13 genes: ADCY2, LPAR1, GNA11, GUCY1B3, ITPR1, PDGFA, PDGFB, PDGFRA, PDGFRB, PRKG1, PDGFC, MAP2K5, TUBB6
|
0.000126 |
| Circadian rhythm . mammal |
6 genes: CRY2, FBXW11, FBXL3, ARNTL, RORA, RORB
|
0.0003426 |
| Neurotrophin signaling pathway |
15 genes: AKT3, SH2B3, IRAK3, MAPK14, FOXO3, IRS1, NTF3, NTRK2, NTRK3, IRAK4, PIK3CD, PIK3CG, PRKCD, MAP2K5, RAP1A
|
0.0003874 |
| Apoptosis |
12 genes: AKT3, IRAK3, IL1RAP, ATM, IRAK4, PIK3CD, PIK3CG, PPP3CB, CAPN2, CASP10, RIPK1, CFLAR
|
0.0004357 |
| Leukocyte transendothelial migration |
14 genes: MYL12A, MAPK14, CTNNA1, ITGAL, RHOH, MMP2, CLDN11, PIK3CD, PIK3CG, RAP1A, ACTN4, RASSF5, ACTN1, ACTN2
|
0.0005246 |
| MAPK signaling pathway |
24 genes: AKT3, DUSP10, MAPK14, GADD45A, DUSP3, DUSP7, FGF7, FGF13, FGF14, MAX, MEF2C, NTF3, NTRK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PPP3CB, MAP2K5, RAP1A, RASGRF2, CACNA1C, CACNB4, FGF18
|
0.000625 |
| Cell adhesion molecules .CAMs. |
15 genes: CNTN1, VCAN, NFASC, NEGR1, HLA-DMB, HLA-DQA1, HLA-DQA2, ITGAL, NCAM1, CLDN11, CADM3, SELP, CD2, CD34, CD40
|
0.000802 |
| Adherens junction |
10 genes: SORBS1, CTNNA1, IGF1R, LMO7, PTPRB, SNAI2, ACTN4, ACTN1, ACTN2, IQGAP1
|
0.001133 |
| Axon guidance |
14 genes: PLXNC1, CFL2, DPYSL2, EPHA3, NTNG1, EPHA6, ABLIM1, NFATC1, PPP3CB, NTN4, RGS3, SEMA6D, NRP1, SEMA3E
|
0.00149 |
| Phosphatidylinositol signaling system |
10 genes: DGKB, INPP1, INPP5A, ITPK1, ITPR1, PIK3CD, PIK3CG, PIP4K2A, PTEN, PLCD4
|
0.001891 |
| p53 signaling pathway |
9 genes: CDK6, GADD45A, IGF1, ATM, SERPINE1, PTEN, ZMAT3, THBS1, CCND3
|
0.002787 |
| Complement and coagulation cascades |
9 genes: CR1, F3, F8, SERPINE1, SERPINA5, PROS1, TFPI, C3AR1, C7
|
0.002787 |
| Inositol phosphate metabolism |
8 genes: INPP1, INPP5A, ITPK1, PIK3CD, PIK3CG, PIP4K2A, PTEN, PLCD4
|
0.002971 |
| Calcium signaling pathway |
16 genes: ADCY2, ADRB3, GNA11, ITPR1, NTSR1, PDE1C, PDGFRA, PDGFRB, PHKB, PLN, PPP3CB, PTGER3, PTGFR, SLC8A1, CACNA1C, PLCD4
|
0.004324 |
| Hematopoietic cell lineage |
10 genes: CR1, IL6R, ITGA1, KIT, CD1A, CD1C, CD1D, CD2, CD34, CD44
|
0.004614 |
| Phagosome |
14 genes: CD209, HLA-DMB, HLA-DQA1, HLA-DQA2, ITGB5, LAMP1, LAMP2, OLR1, ATP6V1B2, THBS1, TLR4, TUBB6, VAMP3, MRC2
|
0.007784 |
| Aldosterone.regulated sodium reabsorption |
6 genes: IGF1, IRS1, NR3C2, PIK3CD, PIK3CG, SCNN1A
|
0.008874 |
| Osteoclast differentiation |
12 genes: AKT3, SIRPA, MAPK14, FOSB, JAK1, LCK, MITF, NFATC1, PIK3CD, PIK3CG, PPP3CB, SYK
|
0.00949 |
| Long.term depression |
8 genes: GNA11, GNAO1, GUCY1B3, IGF1, IGF1R, ITPR1, PPP2CB, PRKG1
|
0.01041 |
| Vascular smooth muscle contraction |
11 genes: CALCRL, ADCY2, GNA11, GUCY1B3, ITPR1, KCNMA1, MYH11, PRKCD, PRKG1, CACNA1C, CALD1
|
0.01172 |
| Tight junction |
12 genes: AKT3, MYL12A, CTNNA1, MYH11, CLDN11, PPP2CB, PRKCD, PTEN, ACTN4, ACTN1, ACTN2, TJP2
|
0.01264 |
| Toll.like receptor signaling pathway |
10 genes: AKT3, MAPK14, IRAK4, PIK3CD, PIK3CG, TOLLIP, TLR1, TLR4, RIPK1, CD40
|
0.01274 |
| B cell receptor signaling pathway |
8 genes: AKT3, PIK3AP1, DAPP1, NFATC1, PIK3CD, PIK3CG, PPP3CB, SYK
|
0.01543 |
| Intestinal immune network for IgA production |
6 genes: HLA-DMB, HLA-DQA1, HLA-DQA2, IL10, IL15, CD40
|
0.01836 |
| Dorso.ventral axis formation |
4 genes: PIWIL4, ETS1, NOTCH2, NOTCH4
|
0.02122 |
| ECM.receptor interaction |
8 genes: COL3A1, COL11A1, ITGA11, ITGA1, ITGB5, RELN, THBS1, CD44
|
0.03036 |
| Progesterone.mediated oocyte maturation |
8 genes: AKT3, ADCY2, MAPK14, IGF1, IGF1R, PGR, PIK3CD, PIK3CG
|
0.03424 |
| Glycosaminoglycan degradation |
3 genes: IDS, NAGLU, HYAL2
|
0.04647 |