Enriched cancer pathwayGenes under regulationP value
Focal adhesion
53 genes: COL3A1, COL4A1, COL4A4, COL4A6, COL6A3, COL11A1, COL6A6, ITGA11, FLT4, FN1, FYN, RAPGEF1, HGF, IGF1R, ITGA1, ITGA5, ITGA9, ITGAV, ITGB1, ITGB3, ITGB8, JUN, KDR, RHOA, LAMA4, LAMC1, SHC4, MYLK, PPP1R12A, COL5A3, PDGFRA, PGF, PIK3R1, PARVA, PRKCA, PRKCB, RELN, PTEN, RAP1A, BCL2, ROCK1, SHC1, TLN1, VCL, VWF, TLN2, ITGA10, CAV2, ACTN1, ACTN2, CCND2, CCND3, ROCK2
3.729e-14
PI3K AKT signaling pathway
69 genes: FGF1, FGF2, FGF7, FGF9, FGF13, FGF18, NGF, CSF1, PGF, HGF, ANGPT1, NGFR, NTRK2, IGF1R, PDGFRA, FLT4, KDR, IL6, IL7, GHR, PRLR, OSMR, IL4R, CSF3R, COL4A4, COL4A6, COL4A1, COL4A3, COL6A3, COL6A6, LAMA4, LAMC1, RELN, FN1, VWF, ITGA1, ITGA5, ITGA9, ITGA10, ITGA11, ITGAV, ITGB1, ITGB3, ITGB8, PIK3R1, F2R, CHRM2, LPAR1, GNB4, GNB5, GNG2, GNG4, GNG12, PRKAA2, DDIT4, PRKCA, PTEN, PPP2R2C, PPP2R3A, PHLPP2, NOS3, MYC, CDKN1A, CDK6, CCND2, CCND3, BCL2, CREB5, NFKB1
3.357e-11
Regulation of actin cytoskeleton
49 genes: ABI2, WASF2, CFL2, IQGAP2, CHRM2, DIAPH2, F2R, FGD1, FGF1, FGF2, FGF7, FGF9, FGF13, RRAS2, ITGA11, MRAS, FN1, TIAM2, GSN, ITGA1, ITGA5, ITGA9, ITGAV, ITGB1, ITGB2, ITGB3, ITGB8, RHOA, MSN, MYLK, PPP1R12A, ARHGEF4, PDGFRA, PIK3R1, PIP4K2A, ENAH, GNG12, RDX, ROCK1, VCL, DIAPH3, ITGA10, ACTN1, ACTN2, FGF18, IQGAP1, WASF1, ARHGEF6, ROCK2
1.059e-10
MAPK signaling pathway
54 genes: RASGRP1, MAP3K2, GADD45G, MAPK14, GADD45A, DUSP1, DUSP3, DUSP5, DUSP7, DUSP8, FGF1, FGF2, FGF7, FGF9, FGF13, RRAS2, MRAS, HSPA8, JUN, MAX, MEF2C, MAP3K3, MYC, NFATC4, NFKB1, NGF, NTRK2, PDGFRA, PLA2G5, PPP3CB, PRKACB, PRKCA, PRKCB, CACNA2D3, GNG12, RAP1A, RASGRF2, RPS6KA2, SRF, TGFB2, TGFBR1, TGFBR2, TNF, CACNA1C, MAP3K12, CACNB2, CACNB4, PTPN5, FGF18, RPS6KA4, MAP3K14, CACNA2D4, MAP4K4, CDC25B
1.828e-09
Ras signaling pathway
49 genes: FGF1, FGF2, FGF7, FGF9, FGF13, FGF18, NGF, CSF1, PGF, HGF, ANGPT1, NGFR, NTRK2, IGF1R, PDGFRA, FLT4, KDR, GAB1, GAB2, SHC1, SHC4, PTPN11, RASGRP1, GNB4, GNB5, GNG2, GNG4, GNG12, PRKACB, RASGRF2, CALM2, CALM1, MRAS, RRAS2, RASAL2, RASSF1, RHOA, PIK3R1, NFKB1, PLA2G5, ETS1, ETS2, KSR1, RAP1A, RGL1, RALB, PRKCA, PRKCB, ABL2
3.629e-09
Gastric acid secretion
24 genes: ADCY2, ADCY5, ADCY7, ADCY9, GNAI1, GNAI2, GNAQ, ITPR1, ITPR2, KCNJ2, KCNJ10, KCNJ16, KCNK2, MYLK, ATP1A2, ATP1B2, PLCB4, PRKACB, PRKCA, PRKCB, CALM1, CALM2, CAMK2A, CAMK2D
4.695e-09
Vascular smooth muscle contraction
31 genes: MRVI1, ADCY2, ADCY5, ADCY7, ADCY9, EDNRA, GNAQ, GUCY1A2, GUCY1A3, GUCY1B3, ITPR1, ITPR2, KCNMA1, KCNMB1, RHOA, MYLK, PPP1R12A, PPP1R12B, PLA2G5, PLCB4, PRKACB, PRKCA, PRKCB, PRKCQ, PRKG1, ROCK1, CACNA1C, CALD1, CALM1, CALM2, ROCK2
5.817e-09
ECM.receptor interaction
25 genes: COL3A1, COL4A1, COL4A4, COL4A6, COL6A3, COL11A1, COL6A6, ITGA11, FN1, HSPG2, ITGA1, ITGA5, ITGA9, ITGAV, ITGB1, ITGB3, ITGB8, LAMA4, LAMC1, COL5A3, RELN, SDC2, VWF, ITGA10, SV2B
2.114e-08
Cell adhesion molecules .CAMs.
33 genes: CDH2, CNTN1, VCAN, CTLA4, NLGN1, NFASC, NEGR1, CNTNAP2, GLG1, CD274, HLA-DMB, HLA-DPA1, HLA-DQA1, HLA-DRB1, ITGA9, ITGAV, ITGB1, ITGB2, ITGB8, NCAM1, NLGN2, JAM2, SDC2, SELE, MPZL1, CD4, CD8B, NRXN1, NRXN2, CD80, CD86, CD34, CD40LG
2.572e-08
Gap junction
24 genes: MAP3K2, ADCY2, ADCY5, ADCY7, ADCY9, LPAR1, GJA1, GNAI1, GNAI2, GNAQ, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, HTR2B, ITPR1, ITPR2, PDGFRA, PLCB4, PRKACB, PRKCA, PRKCB, PRKG1, TUBB2A
3.102e-07
Wnt signaling pathway
30 genes: PRICKLE2, FBXW11, DAAM2, JUN, RHOA, MYC, NFATC4, PLCB4, PPP3CB, PRKACB, PRKCA, PRKCB, ROCK1, SFRP1, SFRP4, PORCN, WNT11, WNT2B, FOSL1, CAMK2A, CAMK2D, AXIN2, FZD4, FZD7, FZD8, TCF7L1, NKD1, CCND2, CCND3, ROCK2
9.409e-06
Melanogenesis
23 genes: ADCY2, ADCY5, ADCY7, ADCY9, EDN1, GNAI1, GNAI2, GNAQ, MITF, PLCB4, PRKACB, PRKCA, PRKCB, WNT11, WNT2B, CALM1, CALM2, CAMK2A, CAMK2D, FZD4, FZD7, FZD8, TCF7L1
1.008e-05
Long.term depression
18 genes: GNAI1, GNAI2, GNAQ, GNAZ, GRIA3, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, IGF1R, ITPR1, ITPR2, LYN, PLA2G5, PLCB4, PRKCA, PRKCB, PRKG1
1.575e-05
Chemokine signaling pathway
34 genes: CXCL13, GNB5, ADCY2, ADCY5, ADCY7, ADCY9, CCR1, CX3CR1, TIAM2, GNAI1, GNAI2, GNG4, CXCL10, RHOA, SHC4, LYN, CXCL9, NFKB1, PIK3R1, PLCB4, GNG2, PRKACB, PRKCB, GNG12, RAP1A, GNB4, ROCK1, CCL8, CCL11, CXCL12, SHC1, STAT3, ROCK2, ELMO1
2.299e-05
Adherens junction
18 genes: WASF2, SORBS1, WASF3, FER, FYN, IGF1R, RHOA, PTPN1, PTPRJ, SNAI2, TGFBR1, TGFBR2, VCL, TCF7L1, ACTN1, ACTN2, IQGAP1, WASF1
2.919e-05
Axon guidance
26 genes: PLXNC1, CFL2, DPYSL2, EPHA3, SEMA3D, NTNG1, FYN, GNAI1, GNAI2, ITGB1, RHOA, NCK1, NFATC4, SEMA5B, PPP3CB, RGS3, ROBO1, ROCK1, CXCL12, SLIT3, SEMA6D, UNC5C, NRP1, UNC5A, NTN1, ROCK2
3.204e-05
Salivary secretion
20 genes: ADCY2, ADCY5, ADCY7, ADCY9, GNAQ, GUCY1A2, GUCY1A3, GUCY1B3, ITPR1, ITPR2, KCNMA1, ATP1A2, ATP1B2, PLCB4, PRKACB, PRKCA, PRKCB, PRKG1, CALM1, CALM2
4.583e-05
Neurotrophin signaling pathway
25 genes: SH2B3, IRAK3, MAPK14, GAB1, RAPGEF1, JUN, RHOA, SHC4, MAP3K3, NFKB1, NGF, NGFR, NTRK2, PIK3R1, PTPN11, RAP1A, BCL2, RPS6KA2, SHC1, CALM1, CALM2, CAMK2A, CAMK2D, IRS2, RPS6KA4
5.933e-05
Long.term potentiation
17 genes: GNAQ, GRM5, ITPR1, ITPR2, PPP1R12A, PLCB4, PPP3CB, PRKACB, PRKCA, PRKCB, RAP1A, RPS6KA2, CACNA1C, CALM1, CALM2, CAMK2A, CAMK2D
5.939e-05
Osteoclast differentiation
25 genes: SIRPB1, SIRPA, MAPK14, CSF1, CTSK, CYBB, CYLD, FYN, IFNG, IFNGR1, ITGB3, JUN, LCP2, MITF, NFKB1, TNFRSF11B, PIK3R1, PPP3CB, TGFB2, TGFBR1, TGFBR2, TNF, FOSL1, MAP3K14, GAB2
6.787e-05
Hippo signaling pathway
28 genes: YAP1, FRMD6, RASSF1, PPP2R2C, LATS2, LATS1, FBXW11, TEAD1, AREG, ITGB2, FGF1, TGFB2, TGFBR1, TGFBR2, GDF6, BMPR1B, WNT2B, WNT11, FZD7, FZD4, FZD8, AXIN2, TCF7L1, MYC, CCND2, CCND3, SNAI2, NKD1
9.648e-05
GnRH signaling pathway
21 genes: MAP3K2, ADCY2, ADCY5, ADCY7, ADCY9, MAPK14, GNAQ, ITPR1, ITPR2, JUN, MAP3K3, PLA2G5, PLCB4, PRKACB, PRKCA, PRKCB, CACNA1C, CALM1, CALM2, CAMK2A, CAMK2D
9.976e-05
Hematopoietic cell lineage
19 genes: CR1, CR2, CSF1, CSF2RA, CSF3R, HLA-DRB1, IL4R, IL6, IL7, ITGA1, ITGA5, ITGB3, MME, TNF, CD1D, CD4, CD8B, MS4A1, CD34
0.0001244
Calcium signaling pathway
30 genes: ADCY2, CHRM2, ADCY7, ADCY9, EDNRA, F2R, GNAQ, GRM5, HTR2B, ITPKB, ITPR1, ITPR2, MYLK, NOS3, ATP2A2, PDGFRA, PLCB4, PPP3CB, PRKACB, PRKCA, PRKCB, PTGER3, PTGFR, TACR1, VDAC2, CACNA1C, CALM1, CALM2, CAMK2A, CAMK2D
0.0002049
Jak.STAT signaling pathway
27 genes: SPRY2, IL24, CNTFR, CSF2RA, CSF3R, SPRED1, CLCF1, GHR, IFNG, IFNGR1, IL4R, IL6, IL6ST, IL7, IL12A, IL15, LEPR, LIFR, MYC, PIK3R1, PRLR, PTPN11, STAT3, CBL, CCND2, CCND3, OSMR
0.0002645
Adipocytokine signaling pathway
15 genes: CAMKK2, PPARGC1A, ACSL4, LEPR, NFKB1, PRKAG2, PRKAA2, PRKAB2, PRKCQ, PTPN11, STAT3, TNF, TNFRSF1B, IRS2, ADIPOQ
0.0004887
T cell receptor signaling pathway
20 genes: RASGRP1, MAPK14, CTLA4, FYN, IFNG, JUN, RHOA, LCP2, NCK1, NFATC4, NFKB1, PIK3R1, PPP3CB, PRKCQ, TNF, CBL, MAP3K14, CD4, CD8B, CD40LG
0.0007146
Leukocyte transendothelial migration
21 genes: MAPK14, CYBB, GNAI1, GNAI2, ITGB1, ITGB2, RHOA, RHOH, MSN, PIK3R1, PRKCA, PRKCB, PTPN11, JAM2, RAP1A, ROCK1, CXCL12, VCL, ACTN1, ACTN2, ROCK2
0.0008155
ErbB signaling pathway
17 genes: CDKN1A, EREG, GAB1, ABL2, NRG1, JUN, AREG, SHC4, MYC, NCK1, PIK3R1, PRKCA, PRKCB, SHC1, CAMK2A, CAMK2D, CBL
0.0009358
Glycosphingolipid biosynthesis . ganglio series
6 genes: ST6GALNAC3, B4GALNT1, ST6GALNAC4, ST3GAL2, ST8SIA1, ST6GALNAC5
0.0009574
Glycosaminoglycan biosynthesis . chondroitin sulfate
7 genes: CHSY1, CHSY3, CHST11, CSGALNACT2, CHST7, XYLT1, CHST3
0.001728
Circadian rhythm . mammal
7 genes: FBXW11, FBXL3, ARNTL, PER1, RORA, RORB, BHLHE40
0.002304
Intestinal immune network for IgA production
11 genes: HLA-DMB, HLA-DPA1, HLA-DQA1, HLA-DRB1, IL6, IL15, CXCL12, MAP3K14, CD80, CD86, CD40LG
0.002306
Pancreatic secretion
17 genes: ADCY2, ADCY5, ADCY7, ADCY9, GNAQ, ITPR1, ITPR2, KCNMA1, RHOA, ATP1A2, ATP1B2, ATP2A2, PLA2G5, PLCB4, PRKCA, PRKCB, RAP1A
0.004886
TGF.beta signaling pathway
15 genes: IFNG, INHBB, RHOA, GDF6, LTBP1, MYC, ROCK1, BMPR1B, TGFB2, TGFBR1, TGFBR2, TNF, ACVR1, NOG, ROCK2
0.005063
Phosphatidylinositol signaling system
14 genes: ITPK1, ITPKB, ITPR1, ITPR2, PIK3C2G, PIK3R1, PIP4K2A, PLCB4, PI4K2A, PRKCA, PRKCB, PTEN, CALM1, CALM2
0.005694
Bile secretion
12 genes: ADCY2, ADCY5, ADCY7, ADCY9, SLCO1B3, LDLR, ATP1A2, ATP1B2, ABCB1, ABCB4, PRKACB, SCARB1
0.01597
Protein digestion and absorption
13 genes: COL3A1, COL4A1, COL4A4, COL4A6, COL6A3, COL11A1, COL6A6, DPP4, ELN, MME, ATP1A2, ATP1B2, COL5A3
0.01875
Insulin signaling pathway
19 genes: SORBS1, PPARGC1A, FOXO1, RAPGEF1, HK1, SHC4, PRKAG2, PIK3R1, PRKAA2, PRKAB2, PRKACB, PRKAR2B, PTPN1, SHC1, PPP1R3B, CALM1, CALM2, IRS2, CBL
0.02478
Toll.like receptor signaling pathway
15 genes: MAPK14, CTSK, LY96, TICAM2, IL6, IL12A, CXCL10, JUN, CXCL9, NFKB1, PIK3R1, TNF, TRAF3, CD80, CD86
0.02548
Ether lipid metabolism
7 genes: ENPP6, PAFAH1B1, ENPP2, PLA2G5, LPCAT2, PLA2G7, AGPS
0.02978
ABC transporters
8 genes: ABCC9, ABCA9, ABCA1, ABCB7, ABCD2, ABCB1, ABCB4, TAP2
0.03029
Antigen processing and presentation
12 genes: CTSB, HLA-DMB, HLA-DPA1, HLA-DQA1, HLA-DRB1, HSPA8, IFNG, CIITA, TAP2, TNF, CD4, CD8B
0.03145
Oocyte meiosis
16 genes: ADCY2, ADCY5, ADCY7, ADCY9, FBXW11, IGF1R, ITPR1, ITPR2, PPP3CB, PRKACB, RPS6KA2, CPEB1, CALM1, CALM2, CAMK2A, CAMK2D
0.03183
Progesterone.mediated oocyte maturation
13 genes: ADCY2, ADCY5, ADCY7, ADCY9, MAPK14, GNAI1, GNAI2, IGF1R, PIK3R1, PRKACB, RPS6KA2, CPEB1, CDC25B
0.03199