| Enriched cancer pathway | Genes under regulation | P value |
|---|
| Neurotrophin signaling pathway |
11 genes: GSK3B, KRAS, PIK3CA, PIK3R1, RAP1A, RPS6KA3, SOS1, TRAF6, CALM1, CAMK2G, CDC42
|
3.966e-05 |
| mTOR signaling pathway |
7 genes: RICTOR, PDPK1, PIK3CA, PIK3R1, PRKAA1, RPS6KA3, TSC1
|
6.382e-05 |
| Insulin signaling pathway |
11 genes: MKNK2, GSK3B, KRAS, PDPK1, PIK3CA, PIK3R1, PRKAA1, PRKAB2, SOS1, TSC1, CALM1
|
8.477e-05 |
| mRNA surveillance pathway |
8 genes: SRRM1, SAP18, PAPOLA, CSTF3, PNN, PPP2R2B, PPP2R5E, PAPOLG
|
0.0002145 |
| ErbB signaling pathway |
8 genes: GSK3B, KRAS, PAK2, PIK3CA, PIK3R1, PRKCA, SOS1, CAMK2G
|
0.000297 |
| Long.term potentiation |
7 genes: KRAS, PPP1R12A, PRKCA, RAP1A, RPS6KA3, CALM1, CAMK2G
|
0.0004236 |
| Focal adhesion |
12 genes: GSK3B, IGF1R, ARHGAP5, PPP1R12A, PAK2, PDPK1, PIK3CA, PIK3R1, PRKCA, RAP1A, SOS1, CDC42
|
0.0005836 |
| RNA transport |
10 genes: SRRM1, SAP18, PAIP1, RPP14, EIF5, NMD3, PNN, THOC2, SUMO2, EIF4G3
|
0.0008172 |
| Phosphatidylinositol signaling system |
7 genes: OCRL, PIK3CA, PIK3R1, PRKCA, CALM1, PIP4K2B, DGKD
|
0.0008173 |
| Aldosterone.regulated sodium reabsorption |
5 genes: KRAS, PDPK1, PIK3CA, PIK3R1, PRKCA
|
0.001292 |
| Oocyte meiosis |
8 genes: IGF1R, PPP2R5E, RPS6KA3, ANAPC1, CALM1, CAMK2G, SMC1A, SLK
|
0.001777 |
| Adherens junction |
6 genes: IGF1R, SMAD2, SMAD3, SMAD4, TJP1, CDC42
|
0.003 |
| Cell cycle |
8 genes: STAG1, GSK3B, SMAD2, SMAD3, SMAD4, ATR, ANAPC1, SMC1A
|
0.003653 |
| T cell receptor signaling pathway |
7 genes: GSK3B, KRAS, PAK2, PIK3CA, PIK3R1, SOS1, CDC42
|
0.005256 |
| Ras signaling pathway |
11 genes: IGF1R, SOS1, CALM1, KRAS, NF1, PAK2, PIK3CA, PIK3R1, RAP1A, CDC42, PRKCA
|
0.006839 |
| Progesterone.mediated oocyte maturation |
6 genes: IGF1R, KRAS, PIK3CA, PIK3R1, RPS6KA3, ANAPC1
|
0.007097 |
| GnRH signaling pathway |
6 genes: KRAS, PRKCA, SOS1, CALM1, CAMK2G, CDC42
|
0.01422 |
| B cell receptor signaling pathway |
5 genes: GSK3B, KRAS, PIK3CA, PIK3R1, SOS1
|
0.01557 |
| VEGF signaling pathway |
5 genes: KRAS, PIK3CA, PIK3R1, PRKCA, CDC42
|
0.01641 |
| Fc epsilon RI signaling pathway |
5 genes: KRAS, PIK3CA, PIK3R1, PRKCA, SOS1
|
0.0191 |
| Ubiquitin mediated proteolysis |
7 genes: MID1, UBA6, ANAPC1, TRAF6, UBE3A, CUL4B, PIAS2
|
0.01937 |
| PI3K AKT signaling pathway |
13 genes: IGF1R, SOS1, KRAS, PIK3CA, PIK3R1, PDPK1, PRKAA1, TSC1, PRKCA, PKN2, PPP2R2B, PPP2R5E, GSK3B
|
0.02092 |
| Regulation of actin cytoskeleton |
9 genes: ARHGEF12, KRAS, PPP1R12A, PAK2, PIK3CA, PIK3R1, SOS1, PIP4K2B, CDC42
|
0.02496 |
| Leukocyte transendothelial migration |
6 genes: ARHGAP5, PIK3CA, PIK3R1, PRKCA, RAP1A, CDC42
|
0.02719 |
| Wnt signaling pathway |
7 genes: GSK3B, SMAD2, SMAD3, SMAD4, PPP2R5E, PRKCA, CAMK2G
|
0.02883 |
| Hippo signaling pathway |
7 genes: YAP1, LIMD1, PPP2R2B, SMAD2, SMAD3, SMAD4, GSK3B
|
0.03161 |
| MAPK signaling pathway |
10 genes: MKNK2, KRAS, NF1, PAK2, PRKCA, RAP1A, RPS6KA3, SOS1, TRAF6, CDC42
|
0.03812 |
| Melanogenesis |
5 genes: GSK3B, KRAS, PRKCA, CALM1, CAMK2G
|
0.04775 |