Enriched cancer pathway | Genes under regulation | P value |
Focal adhesion |
32 genes: COL3A1, COL4A1, COL6A6, HGF, ITGA1, ITGA9, ITGB1, ITGB3, KDR, LAMA4, ARHGAP5, SHC4, MYLK, PDGFA, PDGFRA, PIK3CA, PIK3R1, PPP1CB, PRKCB, MAPK10, PTEN, RAP1A, BCL2, SOS2, THBS1, THBS2, VCL, PDGFD, CAPN2, PIK3R3, ITGA8, CCND2
|
1.605e-09 |
Regulation of actin cytoskeleton |
30 genes: CFL2, DIAPH2, F2R, FGF1, FGF2, FGF7, FGF9, ARHGEF12, NCKAP1L, ITGA1, ITGA9, ITGAM, ITGB1, ITGB3, MYLK, PDGFA, PDGFRA, PIK3CA, PIK3R1, PPP1CB, ENAH, GNG12, RDX, SOS2, VCL, PDGFD, PIP5K1B, PIK3R3, ITGA8, FGF18
|
1.124e-07 |
Ras signaling pathway |
31 genes: FGF1, FGF2, FGF7, FGF9, FGF18, NTF3, PDGFA, PDGFD, HGF, NTRK2, PDGFRA, KDR, SHC4, PTPN11, SOS2, GNG2, GNG12, PRKACB, RASGRF2, GRIN2A, RASAL2, PIK3CA, PIK3R1, PIK3R3, FOXO4, PLA2G5, PLA2G16, ETS1, RAP1A, MAPK10, PRKCB
|
3.059e-07 |
PI3K AKT signaling pathway |
39 genes: FGF1, FGF2, FGF7, FGF9, FGF18, NTF3, PDGFA, PDGFD, HGF, NTRK2, PDGFRA, KDR, SOS2, TLR4, OSM, IL6R, COL4A1, COL6A6, LAMA4, THBS1, THBS2, ITGA1, ITGA8, ITGA9, ITGB1, ITGB3, PIK3CA, PIK3R1, PIK3R3, F2R, GNG2, GNG12, PTEN, PHLPP2, CDK6, CCND2, FOXO3, BCL2, CREB5
|
8.194e-07 |
TGF.beta signaling pathway |
15 genes: ID4, INHBB, LTBP1, SMAD1, SMAD4, SMAD7, PITX2, BMP6, BMPR2, TGFB2, TGFBR1, TGFBR2, THBS1, THBS2, GDF5
|
1.033e-05 |
ECM.receptor interaction |
15 genes: COL3A1, COL4A1, COL6A6, ITGA1, ITGA9, ITGB1, ITGB3, LAMA4, SDC2, THBS1, THBS2, ITGA8, CD47, SDC3, SV2B
|
1.033e-05 |
Calcium signaling pathway |
23 genes: ADCY2, ADRB2, EDNRA, EDNRB, F2R, PLCB1, GNAQ, GRIN2A, SLC25A4, ITPR1, ITPR2, MYLK, ATP2B4, PDE1C, PDGFRA, PLN, PPP3CA, PRKACB, PRKCB, PTGER3, PTGFR, CAMK4, CACNA1G
|
1.2e-05 |
MAPK signaling pathway |
30 genes: MAP3K2, MAP3K8, MAPK14, DUSP5, DUSP8, FGF1, FGF2, FGF7, FGF9, FAS, MEF2C, NTF3, NTRK2, PDGFA, PDGFRA, PLA2G5, PPM1A, PPP3CA, PRKACB, PRKCB, GNG12, MAPK10, RAP1A, RASGRF2, SOS2, TGFB2, TGFBR1, TGFBR2, FGF18, CACNA1G
|
1.286e-05 |
Phosphatidylinositol signaling system |
14 genes: DGKB, DGKH, PLCB1, ITPR1, ITPR2, PIK3C2A, PIK3CA, PIK3R1, PRKCB, PTEN, PIP5K1B, PIK3R3, INPP4B, SYNJ1
|
1.657e-05 |
Neurotrophin signaling pathway |
17 genes: IRAK3, MAPK14, FOXO3, SHC4, NTF3, NTRK2, NTRK3, PIK3CA, PIK3R1, MAPK10, KIDINS220, PTPN11, RAP1A, BCL2, SOS2, CAMK4, PIK3R3
|
0.0001103 |
Vascular smooth muscle contraction |
16 genes: ADCY2, EDNRA, PLCB1, ARHGEF12, GNAQ, ITPR1, ITPR2, MYH11, MYLK, PLA2G5, PPP1CB, PRKACB, PRKCB, PRKCE, PRKG1, CALD1
|
0.0001217 |
Cell adhesion molecules .CAMs. |
17 genes: CNTN1, NLGN1, CADM1, NEGR1, HLA-DQA1, ITGA9, ITGAM, ITGB1, NCAM1, PTPRC, SDC2, SELE, CNTN2, VCAM1, ITGA8, NRXN3, SDC3
|
0.0002559 |
Apoptosis |
13 genes: IRAK3, FAS, ATM, PIK3CA, PIK3R1, PPP3CA, PRKACB, PRKAR1A, PRKAR2A, BCL2, CAPN2, PIK3R3, TNFRSF10D
|
0.0002905 |
Gap junction |
13 genes: MAP3K2, ADCY2, PLCB1, GNAQ, ITPR1, ITPR2, PDGFA, PDGFRA, PRKACB, PRKCB, PRKG1, SOS2, PDGFD
|
0.000325 |
Jak.STAT signaling pathway |
18 genes: SPRY1, SPRY2, CNTFR, IL6R, IL6ST, IL10, LEPR, LIFR, OSM, PIK3CA, PIK3R1, PTPN11, SOS2, STAT3, STAT6, PIK3R3, CCND2, SOCS5
|
0.0004267 |
Long.term potentiation |
11 genes: PLCB1, GNAQ, GRIN2A, ITPR1, ITPR2, PPP1CB, PPP3CA, PRKACB, PRKCB, RAP1A, CAMK4
|
0.0004416 |
Insulin signaling pathway |
16 genes: SORBS1, FOXO1, SHC4, PDE3A, PRKAG2, PIK3CA, PIK3R1, PPP1CB, PRKAB2, PRKACB, PRKAR1A, PRKAR2A, MAPK10, SOS2, PPP1R3B, PIK3R3
|
0.0008863 |
Endocytosis |
20 genes: WWP1, CCR5, VPS37A, ADRB2, DAB2, F2R, RAB11FIP2, DNM3, ARFGAP3, KDR, SMAD7, NEDD4, PDGFRA, RET, SH3GL3, SMAP2, TGFB2, TGFBR1, TGFBR2, PIP5K1B
|
0.001706 |
Gastric acid secretion |
10 genes: ADCY2, PLCB1, GNAQ, ITPR1, ITPR2, KCNK2, MYLK, PRKACB, PRKCB, SSTR2
|
0.002575 |
Hippo signaling pathway |
16 genes: YAP1, LATS1, PPP1CB, DLG2, FGF1, TGFB2, TGFBR1, TGFBR2, SMAD7, SMAD4, BMP6, GDF5, BMPR2, SMAD1, FZD4, CCND2
|
0.002794 |
GnRH signaling pathway |
12 genes: MAP3K2, ADCY2, MAPK14, PLCB1, GNAQ, ITPR1, ITPR2, PLA2G5, PRKACB, PRKCB, MAPK10, SOS2
|
0.003053 |
Fc epsilon RI signaling pathway |
10 genes: MAPK14, PIK3CA, PIK3R1, PLA2G5, PRKCB, PRKCE, MAPK10, SOS2, BTK, PIK3R3
|
0.004175 |
T cell receptor signaling pathway |
12 genes: NFAT5, MAP3K8, MAPK14, IL10, PIK3CA, PIK3R1, PPP3CA, PTPRC, SOS2, PIK3R3, CD3E, GRAP2
|
0.005283 |
Dorso.ventral axis formation |
5 genes: PIWIL4, ETS1, NOTCH2, FMN2, SOS2
|
0.005798 |
Osteoclast differentiation |
13 genes: MAPK14, CYLD, ITGB3, PIK3CA, PIK3R1, PPP3CA, MAPK10, BTK, TGFB2, TGFBR1, TGFBR2, CAMK4, PIK3R3
|
0.008033 |
Chemokine signaling pathway |
17 genes: ADCY2, CCR5, CX3CR1, FOXO3, PLCB1, SHC4, PIK3CA, PIK3R1, GNG2, PRKACB, PRKCB, GNG12, RAP1A, CXCR5, SOS2, STAT3, PIK3R3
|
0.008981 |
Salivary secretion |
10 genes: ADCY2, ADRB2, PLCB1, GNAQ, ITPR1, ITPR2, ATP2B4, PRKACB, PRKCB, PRKG1
|
0.009647 |
Leukocyte transendothelial migration |
12 genes: MAPK14, ITGAM, ITGB1, ARHGAP5, PIK3CA, PIK3R1, PRKCB, PTPN11, RAP1A, VCAM1, VCL, PIK3R3
|
0.009867 |
VEGF signaling pathway |
9 genes: NFAT5, MAPK14, KDR, PIK3CA, PIK3R1, PLA2G5, PPP3CA, PRKCB, PIK3R3
|
0.009874 |
p53 signaling pathway |
8 genes: CDK6, SESN1, FAS, ATM, PTEN, ZMAT3, THBS1, CCND2
|
0.01643 |
Propanoate metabolism |
5 genes: ABAT, ALDH9A1, ACAT1, SUCLG2, SUCLA2
|
0.01672 |
Long.term depression |
8 genes: PLCB1, GNAQ, GRIA3, ITPR1, ITPR2, PLA2G5, PRKCB, PRKG1
|
0.0178 |
Inositol phosphate metabolism |
7 genes: PLCB1, PIK3C2A, PIK3CA, PTEN, PIP5K1B, INPP4B, SYNJ1
|
0.01803 |
Pancreatic secretion |
10 genes: ADCY2, CPA3, PLCB1, GNAQ, ITPR1, ITPR2, ATP2B4, PLA2G5, PRKCB, RAP1A
|
0.022 |
Adherens junction |
8 genes: SORBS1, SMAD4, PTPRB, PTPRJ, SNAI1, TGFBR1, TGFBR2, VCL
|
0.0224 |
B cell receptor signaling pathway |
8 genes: NFAT5, PIK3CA, PIK3R1, PPP3CA, PRKCB, SOS2, BTK, PIK3R3
|
0.0259 |
Fc gamma R.mediated phagocytosis |
9 genes: CFL2, DNM3, PIK3CA, PIK3R1, PRKCB, PRKCE, PTPRC, PIP5K1B, PIK3R3
|
0.03697 |
Adipocytokine signaling pathway |
7 genes: LEPR, PRKAG2, PPARA, PRKAB2, MAPK10, PTPN11, STAT3
|
0.04242 |
Complement and coagulation cascades |
7 genes: CR1, F2R, CFH, TFPI, C1S, C3AR1, C7
|
0.04535 |