| Enriched cancer pathway | Genes under regulation | P value |
|---|
| Cell adhesion molecules .CAMs. |
25 genes: CDH2, CLDN16, CNTN1, NLGN1, NFASC, NEGR1, ITGAV, ITGB1, NCAM1, NCAM2, CLDN11, NLGN4X, PTPRC, SDC2, SELE, SIGLEC1, CNTN2, PDCD1LG2, JAM3, CNTNAP1, ITGA8, CLDN1, NRXN3, NRXN1, CD28
|
2.016e-09 |
| Axon guidance |
23 genes: PLXNC1, SEMA3C, NFAT5, CFL2, DPYSL2, EPHA3, EPHA7, SEMA3D, NTNG1, ARHGEF12, FYN, GNAI1, ITGB1, RHOA, NFATC2, SEMA4C, PPP3CA, PPP3CB, SEMA3G, SEMA6D, NRP1, SEMA5A, SEMA3E
|
1.888e-08 |
| Focal adhesion |
27 genes: COL1A2, COL5A1, EGFR, FYN, HGF, IGF1R, ITGA1, ITGAV, ITGB1, RHOA, LAMC1, PDGFRA, PPP1CB, PRKCB, PDGFC, PTEN, RAP1A, CCND1, BCL2, ACTB, THBS1, THBS2, PDGFD, ITGA8, CAV1, CAV2, CCND2
|
3.914e-07 |
| Calcium signaling pathway |
25 genes: ADCY2, CHRM3, ADCY9, EDNRA, EDNRB, EGFR, PLCB1, GNAL, GNAQ, GRIN2A, ITPKB, ATP2B4, PDE1C, PDGFRA, PPP3CA, PPP3CB, PRKACB, PRKCB, PTGER3, SLC8A1, TRPC1, CACNA1C, CALM1, CAMK2A, CAMK2D
|
4.426e-07 |
| Gastric acid secretion |
15 genes: ADCY2, CHRM3, ADCY9, PLCB1, GNAI1, GNAQ, KCNJ16, KCNK2, ATP1A2, PRKACB, PRKCB, ACTB, CALM1, CAMK2A, CAMK2D
|
9.22e-07 |
| Gap junction |
16 genes: MAP3K2, ADCY2, ADCY9, LPAR1, EGFR, PLCB1, GJA1, GNAI1, GNAQ, GUCY1A2, PDGFRA, PRKACB, PRKCB, PDGFC, TJP1, PDGFD
|
2.537e-06 |
| Melanogenesis |
17 genes: ADCY2, ADCY9, EDNRB, PLCB1, GNAI1, GNAO1, GNAQ, KITLG, MITF, PRKACB, PRKCB, CREB3L2, CALM1, CAMK2A, CAMK2D, FZD4, FZD8
|
2.723e-06 |
| Regulation of actin cytoskeleton |
26 genes: ABI2, CFL2, CHRM3, DIAPH2, EGFR, FGF7, FGF13, MRAS, ARHGEF12, APC, ITGA1, ITGAV, ITGB1, RHOA, PDGFRA, PIP4K2A, SSH1, PPP1CB, ENAH, PDGFC, RDX, ACTB, PDGFD, ITGA8, WASL, ARHGEF6
|
4.74e-06 |
| Long.term potentiation |
13 genes: PLCB1, GNAQ, GRIN2A, PPP1CB, PPP3CA, PPP3CB, PRKACB, PRKCB, RAP1A, CACNA1C, CALM1, CAMK2A, CAMK2D
|
1.339e-05 |
| Wnt signaling pathway |
19 genes: NFAT5, PRICKLE2, PLCB1, APC, RHOA, LRP6, NFATC2, PPP3CA, PPP3CB, PRKACB, PRKCB, CCND1, SFRP1, SKP1, CAMK2A, CAMK2D, FZD4, FZD8, CCND2
|
5.413e-05 |
| PI3K AKT signaling pathway |
33 genes: FGF7, FGF13, BDNF, PDGFC, PDGFD, KITLG, HGF, EGFR, INSR, IGF1R, PDGFRA, TLR4, GHR, IL7R, JAK2, COL1A2, COL4A3, LAMC1, THBS1, THBS2, ITGA1, ITGA8, ITGAV, ITGB1, LPAR1, PRKAA2, PTEN, PPP2R2B, CCND1, CCND2, BCL2, CREB3L2, CREB5
|
6.367e-05 |
| Vascular smooth muscle contraction |
15 genes: CALCRL, ADCY2, ADCY9, EDNRA, PLCB1, ARHGEF12, GNAQ, GUCY1A2, RHOA, PPP1R12B, PPP1CB, PRKACB, PRKCB, CACNA1C, CALM1
|
0.0002371 |
| Ras signaling pathway |
23 genes: FGF7, FGF13, BDNF, PDGFC, PDGFD, KITLG, HGF, EGFR, INSR, IGF1R, PDGFRA, GAB1, PRKACB, GRIN2A, CALM1, MRAS, RHOA, SHOC2, ETS1, RAPGEF5, RAP1A, RGL1, PRKCB
|
0.0004746 |
| Hippo signaling pathway |
17 genes: AMOT, YAP1, WWTR1, FRMD6, PPP2R2B, PPP1CB, DLG2, TEAD1, CTGF, TGFBR1, BMPR2, FZD4, FZD8, APC, CCND1, CCND2, ACTB
|
0.0006271 |
| GnRH signaling pathway |
13 genes: MAP3K2, ADCY2, ADCY9, EGFR, PLCB1, GNAQ, MAP3K3, PRKACB, PRKCB, CACNA1C, CALM1, CAMK2A, CAMK2D
|
0.0006326 |
| ECM.receptor interaction |
11 genes: COL1A2, COL5A1, ITGA1, ITGAV, ITGB1, LAMC1, SDC2, THBS1, THBS2, ITGA8, SV2B
|
0.001546 |
| Adherens junction |
10 genes: EGFR, FYN, IGF1R, INSR, RHOA, PTPRB, ACTB, TGFBR1, TJP1, WASL
|
0.001615 |
| Salivary secretion |
11 genes: ADCY2, CHRM3, ADCY9, PLCB1, GNAQ, GUCY1A2, ATP1A2, ATP2B4, PRKACB, PRKCB, CALM1
|
0.002247 |
| MAPK signaling pathway |
23 genes: MAP3K2, EGFR, FGF7, FGF13, MRAS, HSPA2, MAPT, MEF2C, MAP3K3, NFATC2, PDGFRA, PPM1A, PPP3CA, PPP3CB, PRKACB, PRKCB, RAP1A, BDNF, TGFBR1, CACNA1C, CACNA2D1, CACNB2, RPS6KA5
|
0.002598 |
| Tight junction |
14 genes: CLDN16, MRAS, GNAI1, RHOA, CLDN11, PPP2R2B, PRKCB, ASH1L, PTEN, ACTB, TJP1, JAM3, CLDN1, MAGI2
|
0.002857 |
| Neurotrophin signaling pathway |
13 genes: FRS2, IRAK3, GAB1, RHOA, MAP3K3, NTRK3, RAP1A, BCL2, BDNF, CALM1, CAMK2A, CAMK2D, RPS6KA5
|
0.005039 |
| Oocyte meiosis |
12 genes: ADCY2, ADCY9, IGF1R, AR, PPP1CB, PPP3CA, PPP3CB, PRKACB, SKP1, CALM1, CAMK2A, CAMK2D
|
0.005532 |
| Pancreatic secretion |
11 genes: ADCY2, CHRM3, ADCY9, PLCB1, GNAQ, RHOA, ATP1A2, ATP2B4, PRKCB, RAP1A, TRPC1
|
0.006001 |
| Purine metabolism |
15 genes: ADCY2, ADCY9, PDE7B, GUCY1A2, RRM2B, PDE1C, PDE3A, PDE4B, PDE4D, PDE8A, ENPP1, POLR3GL, PDE5A, PAPSS2, ENTPD1
|
0.006898 |
| Glycosaminoglycan degradation |
4 genes: HGSNAT, GNS, IDS, ARSB
|
0.009403 |
| Insulin signaling pathway |
13 genes: PPARGC1A, FOXO1, RHOQ, INSR, PDE3A, PPP1CB, PRKAA2, PRKAB2, PRKACB, PRKAR2A, PPP1R3B, CALM1, SOCS2
|
0.009957 |
| Endocytosis |
17 genes: STAM2, RAB31, EGFR, RAB11FIP2, DNM3, HSPA2, IGF1R, RHOA, NEDD4, VPS36, SH3GLB1, PDGFRA, TGFBR1, EEA1, CAV1, CAV2, RABEP1
|
0.01111 |
| Inositol phosphate metabolism |
7 genes: PLCB1, ITPK1, ITPKB, ALDH6A1, PIP4K2A, PI4K2A, PTEN
|
0.01408 |
| TGF.beta signaling pathway |
9 genes: DCN, RHOA, LTBP1, SKP1, BMPR2, TGFBR1, THBS1, THBS2, ACVR2A
|
0.01466 |
| Circadian rhythm . mammal |
4 genes: FBXL3, RORA, SKP1, PER3
|
0.01862 |
| Phosphatidylinositol signaling system |
8 genes: PLCB1, ITPK1, ITPKB, PIP4K2A, PI4K2A, PRKCB, PTEN, CALM1
|
0.02466 |
| Dorso.ventral axis formation |
4 genes: EGFR, ETS1, NOTCH2, PIWIL2
|
0.02477 |
| p53 signaling pathway |
7 genes: SESN3, RRM2B, PTEN, CCND1, ZMAT3, THBS1, CCND2
|
0.03623 |
| Long.term depression |
7 genes: PLCB1, GNAI1, GNAO1, GNAQ, GUCY1A2, IGF1R, PRKCB
|
0.03875 |
| Leukocyte transendothelial migration |
10 genes: CLDN16, GNAI1, ITGB1, RHOA, CLDN11, PRKCB, RAP1A, ACTB, JAM3, CLDN1
|
0.03975 |
| Histidine metabolism |
4 genes: ALDH1B1, HNMT, MAOA, ALDH7A1
|
0.04038 |
| Mucin type O.Glycan biosynthesis |
4 genes: GALNT13, GCNT4, GALNT10, GALNT11
|
0.04498 |
| Valine. leucine and isoleucine degradation |
5 genes: ABAT, ALDH1B1, ACADSB, ALDH6A1, ALDH7A1
|
0.04768 |
| Jak.STAT signaling pathway |
12 genes: STAM2, GHR, IL6ST, IL7R, JAK2, LEPR, LIFR, CCND1, TPO, SOCS2, CCND2, SOCS5
|
0.04947 |