| Enriched cancer pathway | Genes under regulation | P value |
|---|
| MAPK signaling pathway |
24 genes: AKT3, MAP3K2, MAP3K8, CRK, DUSP8, FGFR1, RRAS2, GNA12, NR4A1, JUN, MAP3K3, TAOK3, PDGFRA, PPM1A, PPP3CA, PRKACB, TAOK1, RASGRF2, RPS6KA3, TGFBR2, MAP3K12, MAP3K14, RPS6KA5, RAPGEF2
|
1.901e-06 |
| Circadian rhythm . mammal |
6 genes: CRY2, FBXW11, FBXL3, RORA, PER2, CLOCK
|
4.555e-05 |
| PI3K AKT signaling pathway |
24 genes: CSF1, FGFR1, PDGFRA, IL6R, JAK1, COL1A1, COL4A3, THBS2, ITGB8, PIK3R1, GNB4, PDPK1, PRKAA2, AKT3, PTEN, PPP2R2A, PPP2R3A, PHLPP2, CDKN1A, CDK6, CCND2, CREB5, MCL1, NR4A1
|
0.0001583 |
| Osteoclast differentiation |
12 genes: AKT3, CSF1, CTSK, FHL2, FYN, JAK1, JUN, PIK3R1, PPP3CA, TGFBR2, SQSTM1, MAP3K14
|
0.0004635 |
| Adipocytokine signaling pathway |
8 genes: AKT3, CPT1A, ACSL4, PPARA, PRKAA2, SLC2A4, STAT3, TNFRSF1B
|
0.0009297 |
| Vasopressin.regulated water reabsorption |
6 genes: DCTN6, ADCY9, DCTN1, DYNC1LI2, PRKACB, CREB5
|
0.001871 |
| mTOR signaling pathway |
6 genes: AKT3, HIF1A, PDPK1, PIK3R1, PRKAA2, RPS6KA3
|
0.004415 |
| ErbB signaling pathway |
8 genes: AKT3, CDKN1A, CRK, EREG, GAB1, ABL2, JUN, PIK3R1
|
0.00449 |
| Neurotrophin signaling pathway |
10 genes: AKT3, SH2B3, CRK, GAB1, JUN, MAP3K3, NTRK3, PIK3R1, RPS6KA3, RPS6KA5
|
0.004854 |
| Focal adhesion |
13 genes: AKT3, COL1A1, CRK, FYN, ITGB8, JUN, PDGFRA, PDPK1, PIK3R1, PTEN, THBS2, CAV2, CCND2
|
0.007328 |
| Insulin signaling pathway |
10 genes: AKT3, CRK, HK1, PDE3B, PDPK1, PIK3R1, PRKAA2, PRKACB, SLC2A4, PPP1R3B
|
0.008596 |
| GnRH signaling pathway |
8 genes: MAP3K2, ADCY9, PLCB1, GNA11, GNAQ, JUN, MAP3K3, PRKACB
|
0.01083 |
| Progesterone.mediated oocyte maturation |
7 genes: AKT3, ADCY9, PDE3B, PGR, PIK3R1, PRKACB, RPS6KA3
|
0.01538 |
| T cell receptor signaling pathway |
8 genes: AKT3, NFAT5, MAP3K8, FYN, JUN, PIK3R1, PPP3CA, MAP3K14
|
0.01577 |
| p53 signaling pathway |
6 genes: CDK6, CDKN1A, SESN3, PTEN, ZMAT3, CCND2
|
0.01703 |
| Hippo signaling pathway |
10 genes: FRMD6, PPP2R2A, LATS2, FBXW11, TEAD1, TGFBR2, SMAD7, BMPR2, TCF7L1, CCND2
|
0.01756 |
| Gap junction |
7 genes: MAP3K2, ADCY9, PLCB1, GNA11, GNAQ, PDGFRA, PRKACB
|
0.01823 |
| Endocytosis |
12 genes: DAB2, AP2A2, RAB11FIP5, LDLR, SMAD7, SH3GLB1, PDGFRA, PSD, TGFBR2, EEA1, CAV2, RABEP1
|
0.01939 |
| Oocyte meiosis |
8 genes: ADCY9, FBXW11, AR, PGR, PPP3CA, PRKACB, RPS6KA3, SLK
|
0.02115 |
| Vascular smooth muscle contraction |
8 genes: ADCY9, PLCB1, GNA11, GNA12, GNAQ, KCNMA1, PRKACB, CALD1
|
0.0232 |
| Ras signaling pathway |
13 genes: CSF1, FGFR1, PDGFRA, GAB1, GNB4, PRKACB, RASGRF2, RRAS2, PIK3R1, AKT3, SHOC2, RGL1, ABL2
|
0.02572 |
| Sphingolipid metabolism |
4 genes: KDSR, SGMS1, ACER3, CERK
|
0.03092 |
| Wnt signaling pathway |
9 genes: NFAT5, PLCB1, FBXW11, JUN, PPP3CA, PRKACB, TBL1X, TCF7L1, CCND2
|
0.03789 |
| Axon guidance |
8 genes: NFAT5, CFL2, DPYSL2, EPHA7, FYN, PPP3CA, NTN4, NTN1
|
0.04159 |
| Carbohydrate digestion and absorption |
4 genes: AKT3, HK1, ATP1A2, PIK3R1
|
0.04188 |
| Tight junction |
8 genes: AKT3, CLDN16, RRAS2, MAGI3, PPP2R2A, ASH1L, PTEN, MPDZ
|
0.04651 |