| Enriched cancer pathway | Genes under regulation | P value |
|---|
| Focal adhesion |
22 genes: COL4A6, DOCK1, FN1, PIP5K1C, FYN, IGF1R, LAMC1, SHC4, PPP1R12A, PAK3, PDGFRA, PIK3R1, BCL2, SHC1, THBS2, TLN1, VCL, ZYX, TLN2, CAV1, CCND2, CCND3
|
4.115e-08 |
| Regulation of actin cytoskeleton |
18 genes: ABI2, WASF2, DIAPH2, DOCK1, FGF9, FGF14, MRAS, FN1, PIP5K1C, MSN, PPP1R12A, PAK3, ARHGEF4, PDGFRA, PIK3R1, GNG12, RDX, VCL
|
3.061e-05 |
| Calcium signaling pathway |
16 genes: EDNRA, EDNRB, GNA11, GNAQ, ITPR1, ITPR2, ATP2B4, PDGFRA, PLCB4, PPP3CA, PRKACB, PTGER3, SLC8A1, CACNA1C, CAMK4, CACNA1G
|
3.506e-05 |
| MAPK signaling pathway |
20 genes: MAP3K2, FGF9, FGF14, MRAS, HSPA2, MAPT, MEF2C, MAP3K3, PDGFRA, PPP3CA, PRKACB, GNG12, DUSP22, TGFBR1, CACNA1C, CACNA2D1, CACNB2, CACNB4, CACNA1G, MAP4K4
|
6.25e-05 |
| Long.term potentiation |
9 genes: GNAQ, ITPR1, ITPR2, PPP1R12A, PLCB4, PPP3CA, PRKACB, CACNA1C, CAMK4
|
0.0001301 |
| Vascular smooth muscle contraction |
11 genes: CALCRL, EDNRA, GNA11, GNAQ, ITPR1, ITPR2, PPP1R12A, PLCB4, PRKACB, PRKG1, CACNA1C
|
0.0003803 |
| GnRH signaling pathway |
10 genes: MAP3K2, HBEGF, GNA11, GNAQ, ITPR1, ITPR2, MAP3K3, PLCB4, PRKACB, CACNA1C
|
0.0004926 |
| Glycosaminoglycan biosynthesis . keratan sulfate |
4 genes: ST3GAL2, ST3GAL3, CHST1, B3GNT7
|
0.0006233 |
| Gap junction |
9 genes: MAP3K2, GNA11, GNAQ, ITPR1, ITPR2, PDGFRA, PLCB4, PRKACB, PRKG1
|
0.0008674 |
| Ras signaling pathway |
16 genes: FGF9, FGF14, CSF1, IGF1R, PDGFRA, SHC1, SHC4, GNB4, GNG7, GNG12, PRKACB, MRAS, PAK3, PIK3R1, RGL1, RALB
|
0.0009402 |
| PI3K AKT signaling pathway |
20 genes: FGF9, FGF14, CSF1, IGF1R, PDGFRA, IRS1, COL4A6, LAMC1, THBS2, FN1, PIK3R1, GNB4, GNG7, GNG12, PRKAA2, CDKN1A, CCND2, CCND3, FOXO3, BCL2
|
0.001981 |
| Chemokine signaling pathway |
13 genes: FOXO3, GNG7, SHC4, PIK3R1, PLCB4, PRKACB, GNG12, GNB4, CXCL12, CXCR5, SHC1, STAT1, ELMO1
|
0.002415 |
| ECM.receptor interaction |
8 genes: COL4A6, FN1, LAMC1, SDC2, THBS2, CD36, CD47, SV2B
|
0.002446 |
| Long.term depression |
7 genes: GNA11, GNAQ, IGF1R, ITPR1, ITPR2, PLCB4, PRKG1
|
0.003199 |
| Axon guidance |
10 genes: EPHA3, EPHB1, FYN, L1CAM, PAK3, PLXNA2, PPP3CA, CXCL12, SLIT3, UNC5C
|
0.003358 |
| Hippo signaling pathway |
11 genes: LATS2, FBXW11, TEAD1, TGFBR1, SMAD7, BMPR2, SMAD1, WNT9A, CCND2, CCND3, SNAI2
|
0.003808 |
| Endocytosis |
13 genes: DAB2, PIP5K1C, RAB11FIP5, HSPA2, IGF1R, SMAD7, PDGFRA, PML, TGFBR1, RUFY1, EEA1, CAV1, GIT2
|
0.004449 |
| Cardiac muscle contraction |
7 genes: SLC8A1, TPM1, TPM2, CACNA1C, CACNA2D1, CACNB2, CACNB4
|
0.005441 |
| Glycosphingolipid biosynthesis . ganglio series |
3 genes: ST6GALNAC3, B4GALNT1, ST3GAL2
|
0.007502 |
| Neurotrophin signaling pathway |
9 genes: FOXO3, IRS1, SHC4, MAP3K3, NTRK3, PIK3R1, BCL2, SHC1, CAMK4
|
0.008897 |
| Osteoclast differentiation |
9 genes: CSF1, CYLD, FYN, MITF, PIK3R1, PPP3CA, STAT1, TGFBR1, CAMK4
|
0.009343 |
| Wnt signaling pathway |
10 genes: DAAM1, FBXW11, PLCB4, PPP3CA, PRKACB, SFRP1, TBL1X, WNT9A, CCND2, CCND3
|
0.009478 |
| Salivary secretion |
7 genes: GNAQ, ITPR1, ITPR2, ATP2B4, PLCB4, PRKACB, PRKG1
|
0.01176 |
| Cell adhesion molecules .CAMs. |
9 genes: CNTN1, CADM1, L1CAM, NCAM1, NCAM2, NLGN4X, NLGN2, SDC2, NRXN1
|
0.01354 |
| Insulin signaling pathway |
9 genes: FLOT1, FOXO1, IRS1, SHC4, PIK3R1, PRKAA2, PRKACB, PRKAR1A, SHC1
|
0.01478 |
| Adherens junction |
6 genes: WASF2, FYN, IGF1R, SNAI2, TGFBR1, VCL
|
0.01565 |
| Gastric acid secretion |
6 genes: GNAQ, ITPR1, ITPR2, KCNJ2, PLCB4, PRKACB
|
0.01665 |
| Hedgehog signaling pathway |
5 genes: FBXW11, RAB23, PRKACB, HHIP, WNT9A
|
0.01919 |
| Phosphatidylinositol signaling system |
6 genes: PIP5K1C, INPP5A, ITPR1, ITPR2, PIK3R1, PLCB4
|
0.02106 |
| TGF.beta signaling pathway |
6 genes: SMAD1, SMAD7, BMPR2, TGFBR1, THBS2, ACVR1
|
0.03058 |
| Lysine degradation |
4 genes: OGDH, PLOD2, ASH1L, SETD7
|
0.03303 |
| ErbB signaling pathway |
6 genes: CDKN1A, HBEGF, SHC4, PAK3, PIK3R1, SHC1
|
0.03374 |
| Oocyte meiosis |
7 genes: FBXW11, IGF1R, ITPR1, ITPR2, PPP3CA, PRKACB, CPEB1
|
0.03931 |