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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-550a-5p ADAMTS6 2.11 0 -0.88 0.01914 MirTarget -0.31 0 NA
2 hsa-miR-550a-5p ADAMTSL5 2.11 0 -0.41 0.32739 MirTarget -0.19 0.00269 NA
3 hsa-miR-550a-5p ADCYAP1 2.11 0 -3.51 0 MirTarget -0.65 0 NA
4 hsa-miR-550a-5p ADPRH 2.11 0 -0.71 0.00334 MirTarget -0.11 0.0041 NA
5 hsa-miR-550a-5p AFAP1 2.11 0 -0.98 0.00012 mirMAP -0.17 2.0E-5 NA
6 hsa-miR-550a-5p ARL10 2.11 0 -1.12 0.00198 mirMAP -0.13 0.01915 NA
7 hsa-miR-550a-5p ARRB1 2.11 0 -1.05 0.00043 MirTarget -0.21 0 NA
8 hsa-miR-550a-5p ARSB 2.11 0 -0.58 0.00052 MirTarget -0.1 5.0E-5 NA
9 hsa-miR-550a-5p ATP1A2 2.11 0 -6.96 0 MirTarget -1.18 0 NA
10 hsa-miR-550a-5p BATF3 2.11 0 -0.55 0.12374 MirTarget -0.17 0.00261 NA
11 hsa-miR-550a-5p BCL2L2 2.11 0 -1.27 0 MirTarget -0.11 3.0E-5 NA
12 hsa-miR-550a-5p C9orf3 2.11 0 -1.1 0 mirMAP -0.18 0 NA
13 hsa-miR-550a-5p CCDC3 2.11 0 -1.68 0 MirTarget -0.23 0 NA
14 hsa-miR-550a-5p CCND2 2.11 0 -2.43 0 MirTarget -0.45 0 NA
15 hsa-miR-550a-5p CD302 2.11 0 -1.68 0 MirTarget -0.15 0 NA
16 hsa-miR-550a-5p CDH5 2.11 0 -1.15 1.0E-5 MirTarget -0.25 0 NA
17 hsa-miR-550a-5p CGNL1 2.11 0 -3.39 0 MirTarget -0.48 0 NA
18 hsa-miR-550a-5p CHD5 2.11 0 -3.46 0 mirMAP -0.38 0 NA
19 hsa-miR-550a-5p CHURC1 2.11 0 -0.79 0 MirTarget -0.11 0 NA
20 hsa-miR-550a-5p CX3CR1 2.11 0 -1.46 8.0E-5 MirTarget -0.27 0 NA
21 hsa-miR-550a-5p DSTN 2.11 0 -1.58 0 MirTarget -0.22 0 NA
22 hsa-miR-550a-5p EMX2 2.11 0 -0.58 0.47251 MirTarget -0.25 0.04938 NA
23 hsa-miR-550a-5p FBXL7 2.11 0 -2.71 0 MirTarget -0.45 0 NA
24 hsa-miR-550a-5p FGF1 2.11 0 -0.02 0.96252 MirTarget -0.28 0 NA
25 hsa-miR-550a-5p GFRA1 2.11 0 -5 0 mirMAP -0.68 0 NA
26 hsa-miR-550a-5p GIMAP4 2.11 0 -1 0.00056 MirTarget -0.21 0 NA
27 hsa-miR-550a-5p HAPLN4 2.11 0 0.13 0.77621 MirTarget -0.15 0.03133 NA
28 hsa-miR-550a-5p IGDCC4 2.11 0 -1.99 0 MirTarget -0.31 0 NA
29 hsa-miR-550a-5p IGSF21 2.11 0 -2.11 6.0E-5 MirTarget -0.46 0 NA
30 hsa-miR-550a-5p ITPRIP 2.11 0 -1.25 0 MirTarget -0.15 0.00016 NA
31 hsa-miR-550a-5p KCNAB2 2.11 0 -0.72 0.01568 mirMAP -0.1 0.02594 NA
32 hsa-miR-550a-5p KIAA0513 2.11 0 -1.87 0 mirMAP -0.33 0 NA
33 hsa-miR-550a-5p KLHL6 2.11 0 -0.44 0.25234 MirTarget -0.16 0.00624 NA
34 hsa-miR-550a-5p LMF1 2.11 0 -0.64 0.0221 MirTarget -0.16 0.00017 NA
35 hsa-miR-550a-5p MAN1A1 2.11 0 -1.2 0.00088 MirTarget -0.19 0.00086 NA
36 hsa-miR-550a-5p NCAM1 2.11 0 -5.47 0 MirTarget -0.87 0 NA
37 hsa-miR-550a-5p NCS1 2.11 0 -1.74 0 mirMAP -0.18 0 NA
38 hsa-miR-550a-5p NFAM1 2.11 0 -0.41 0.29954 mirMAP -0.17 0.00624 NA
39 hsa-miR-550a-5p NTSR1 2.11 0 -1.44 0.00597 mirMAP -0.17 0.03224 NA
40 hsa-miR-550a-5p PCDH18 2.11 0 -2.11 0 MirTarget -0.33 0 NA
41 hsa-miR-550a-5p PDGFRA 2.11 0 -2.38 0 MirTarget -0.45 0 NA
42 hsa-miR-550a-5p PIP5K1C 2.11 0 -0.76 0 mirMAP -0.14 0 NA
43 hsa-miR-550a-5p PSAPL1 2.11 0 0.5 0.52601 mirMAP -0.36 0.0032 NA
44 hsa-miR-550a-5p PTGS1 2.11 0 -4.36 0 miRNAWalker2 validate -0.71 0 NA
45 hsa-miR-550a-5p RGS9BP 2.11 0 -1.03 0.02812 MirTarget -0.27 0.00023 NA
46 hsa-miR-550a-5p RIMBP2 2.11 0 -2.69 0 MirTarget -0.36 2.0E-5 NA
47 hsa-miR-550a-5p SCARA3 2.11 0 -1.81 3.0E-5 MirTarget -0.2 0.00274 NA
48 hsa-miR-550a-5p SDC3 2.11 0 -1.17 0 mirMAP -0.16 0 NA
49 hsa-miR-550a-5p SLC25A23 2.11 0 -1.91 0 MirTarget -0.33 0 NA
50 hsa-miR-550a-5p SLC9A9 2.11 0 -2.56 0 MirTarget -0.34 0 NA
51 hsa-miR-550a-5p SORCS2 2.11 0 -2.76 1.0E-5 MirTarget -0.51 0 NA
52 hsa-miR-550a-5p SOX13 2.11 0 -0.05 0.81262 MirTarget -0.12 0.00028 NA
53 hsa-miR-550a-5p SPSB1 2.11 0 -0.52 0.01299 MirTarget -0.17 0 NA
54 hsa-miR-550a-5p ST6GALNAC6 2.11 0 -1.24 0 MirTarget -0.19 0 NA
55 hsa-miR-550a-5p SV2B 2.11 0 -2.33 7.0E-5 MirTarget -0.43 0 NA
56 hsa-miR-550a-5p TBC1D10C 2.11 0 -0.82 0.06324 MirTarget -0.23 0.00079 NA
57 hsa-miR-550a-5p THBS3 2.11 0 -0.43 0.03737 MirTarget -0.13 4.0E-5 NA
58 hsa-miR-550a-5p TIMP2 2.11 0 -1.75 1.0E-5 MirTarget -0.43 0 NA
59 hsa-miR-550a-5p TMEM106A 2.11 0 -1.16 0.00142 MirTarget -0.22 6.0E-5 NA
60 hsa-miR-550a-5p TPPP 2.11 0 -4.07 0 mirMAP -0.38 0 NA
61 hsa-miR-550a-5p TRAK2 2.11 0 -1 0 MirTarget -0.15 0 NA
62 hsa-miR-550a-5p TSHZ3 2.11 0 -2.38 0 MirTarget -0.48 0 NA
63 hsa-miR-550a-5p TSPAN18 2.11 0 -2.63 0 mirMAP -0.55 0 NA
64 hsa-miR-550a-5p TUSC5 2.11 0 -3.73 0 MirTarget -0.69 0 NA
65 hsa-miR-550a-5p WDFY4 2.11 0 -1.53 0.00209 mirMAP -0.37 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 4 199 0.004011 0.2036
2 Hedgehog_signaling_pathway_hsa04340 2 47 0.01023 0.2036
3 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.01175 0.2036
4 PI3K_Akt_signaling_pathway_hsa04151 4 352 0.02757 0.262
5 ECM_receptor_interaction_hsa04512 2 82 0.02924 0.262
6 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.03023 0.262
7 Endocytosis_hsa04144 3 244 0.04509 0.3349
8 Lysosome_hsa04142 2 123 0.06072 0.3947
9 MAPK_signaling_pathway_hsa04010 3 295 0.0712 0.4114
10 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.08174 0.4225
11 Hippo_signaling_pathway_hsa04390 2 154 0.08952 0.4225
12 Jak_STAT_signaling_pathway_hsa04630 2 162 0.0975 0.4225
13 Calcium_signaling_pathway_hsa04020 2 182 0.1183 0.4731
14 Rap1_signaling_pathway_hsa04015 2 206 0.1445 0.5367
15 Ras_signaling_pathway_hsa04014 2 232 0.1741 0.6036
16 Cytokine_cytokine_receptor_interaction_hsa04060 2 270 0.2189 0.6696

Quest ID: 017ae5aecadc9006c325f528646f25cc