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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-140-5p ABCD3 -0.76 0 0.36 0.0002 miRanda -0.18 0 NA
2 hsa-miR-140-5p ABHD1 -0.76 0 -0.98 0 miRanda -0.13 0.01184 NA
3 hsa-miR-140-5p ADAMTS13 -0.76 0 0.49 0.00058 mirMAP -0.38 0 NA
4 hsa-miR-140-5p ADCY1 -0.76 0 -0.05 0.84149 mirMAP -0.43 0 NA
5 hsa-miR-140-5p ADCY6 -0.76 0 -0.63 0 MirTarget; PITA; miRanda; miRNATAP -0.16 0 NA
6 hsa-miR-140-5p ALOX15B -0.76 0 -0.75 0.01908 miRanda -0.25 0.0205 NA
7 hsa-miR-140-5p AMACR -0.76 0 0.53 0 miRanda -0.15 0 NA
8 hsa-miR-140-5p ANKRD42 -0.76 0 0.22 0.01213 MirTarget; miRanda -0.21 0 NA
9 hsa-miR-140-5p ANKRD52 -0.76 0 0.23 0.00024 PITA; miRanda; miRNATAP -0.12 0 NA
10 hsa-miR-140-5p ANKS1B -0.76 0 0.2 0.2194 miRanda -0.32 0 NA
11 hsa-miR-140-5p AP1AR -0.76 0 0.37 0 miRanda -0.11 2.0E-5 NA
12 hsa-miR-140-5p AP2B1 -0.76 0 0.26 0.00183 PITA; miRanda -0.13 0 NA
13 hsa-miR-140-5p ARFIP2 -0.76 0 0.83 0 PITA; miRanda -0.3 0 NA
14 hsa-miR-140-5p ARHGAP32 -0.76 0 0.43 9.0E-5 miRanda -0.19 0 NA
15 hsa-miR-140-5p ARHGEF18 -0.76 0 0.6 0 miRanda -0.11 0 NA
16 hsa-miR-140-5p ARMC9 -0.76 0 1.05 0 miRanda -0.26 0 NA
17 hsa-miR-140-5p ARV1 -0.76 0 0.72 0 miRanda -0.13 0 NA
18 hsa-miR-140-5p ATG4B -0.76 0 0.43 0 miRanda -0.11 0 NA
19 hsa-miR-140-5p ATP6V1G1 -0.76 0 0.81 0 miRanda -0.17 0 NA
20 hsa-miR-140-5p B3GALT6 -0.76 0 0.69 0 miRanda -0.16 0 NA
21 hsa-miR-140-5p BBC3 -0.76 0 1.65 0 miRNATAP -0.47 0 NA
22 hsa-miR-140-5p BBS4 -0.76 0 0.09 0.27948 miRanda -0.15 0 NA
23 hsa-miR-140-5p BCL2L1 -0.76 0 0.52 0 PITA; miRanda; miRNATAP -0.18 0 NA
24 hsa-miR-140-5p BCL9 -0.76 0 1.09 0 MirTarget; PITA; miRanda; miRNATAP -0.21 0 NA
25 hsa-miR-140-5p BMP8A -0.76 0 2.55 0 miRanda -0.17 0.00068 NA
26 hsa-miR-140-5p BRD8 -0.76 0 0.07 0.22169 miRanda -0.11 0 NA
27 hsa-miR-140-5p BSN -0.76 0 -0.24 0.13233 mirMAP -0.15 0.0064 NA
28 hsa-miR-140-5p CADPS -0.76 0 1.86 0 miRanda -0.29 2.0E-5 NA
29 hsa-miR-140-5p CAMK2N1 -0.76 0 0.27 0.07667 PITA; miRanda -0.29 0 NA
30 hsa-miR-140-5p CAPN1 -0.76 0 0.6 0 miRanda; miRNATAP -0.12 0 NA
31 hsa-miR-140-5p CARD10 -0.76 0 -0.48 6.0E-5 miRanda -0.13 0.00133 NA
32 hsa-miR-140-5p CASC1 -0.76 0 0.07 0.72877 miRanda -0.54 0 NA
33 hsa-miR-140-5p CASD1 -0.76 0 -0.07 0.57131 miRNAWalker2 validate -0.1 0.00691 NA
34 hsa-miR-140-5p CBWD3 -0.76 0 0.89 0 miRanda -0.2 0 NA
35 hsa-miR-140-5p CC2D1A -0.76 0 0.42 0 miRanda -0.16 0 NA
36 hsa-miR-140-5p CCDC120 -0.76 0 0.74 0 miRanda -0.15 0 NA
37 hsa-miR-140-5p CCDC13 -0.76 0 -0.04 0.76305 miRanda -0.12 0.00611 NA
38 hsa-miR-140-5p CCDC30 -0.76 0 0.19 0.10313 miRanda -0.29 0 NA
39 hsa-miR-140-5p CCDC78 -0.76 0 3.58 0 miRanda -0.82 0 NA
40 hsa-miR-140-5p CCNB1 -0.76 0 2.42 0 miRanda -0.15 0.00114 NA
41 hsa-miR-140-5p CCNF -0.76 0 1.72 0 miRanda -0.21 0 NA
42 hsa-miR-140-5p CD276 -0.76 0 0.96 0 miRanda -0.1 1.0E-5 NA
43 hsa-miR-140-5p CD46 -0.76 0 0.22 0.00794 miRanda -0.14 0 NA
44 hsa-miR-140-5p CDHR3 -0.76 0 -0.46 0.04587 miRanda -0.2 0.01135 NA
45 hsa-miR-140-5p CDK1 -0.76 0 3.03 0 miRanda -0.14 0.01652 NA
46 hsa-miR-140-5p CDKN3 -0.76 0 3.05 0 miRanda -0.14 0.01639 NA
47 hsa-miR-140-5p CEACAM6 -0.76 0 3.15 0 miRanda -0.72 0 NA
48 hsa-miR-140-5p CELF3 -0.76 0 2.06 0 miRanda -0.55 0 NA
49 hsa-miR-140-5p CERCAM -0.76 0 1.06 0 miRanda; miRNATAP -0.25 0 NA
50 hsa-miR-140-5p CHST15 -0.76 0 0.52 0 miRanda -0.23 0 NA
51 hsa-miR-140-5p CLEC5A -0.76 0 2.97 0 miRanda -0.14 0.03363 NA
52 hsa-miR-140-5p COPG2 -0.76 0 0.25 0.00034 miRanda -0.13 0 NA
53 hsa-miR-140-5p COQ4 -0.76 0 0.53 0 miRanda -0.25 0 NA
54 hsa-miR-140-5p CORIN -0.76 0 2 0 miRanda -0.34 0 NA
55 hsa-miR-140-5p CORO2A -0.76 0 1.38 0 MirTarget; miRanda; miRNATAP -0.29 0 NA
56 hsa-miR-140-5p CREB3L1 -0.76 0 1.98 0 MirTarget; miRanda; miRNATAP -0.45 0 NA
57 hsa-miR-140-5p CREB3L4 -0.76 0 1.73 0 miRanda -0.57 0 NA
58 hsa-miR-140-5p CROT -0.76 0 0.04 0.77707 miRNATAP -0.28 0 NA
59 hsa-miR-140-5p CST9L -0.76 0 0.9 0.00141 miRanda -0.54 0 NA
60 hsa-miR-140-5p CTSF -0.76 0 -0.45 5.0E-5 miRanda -0.15 4.0E-5 NA
61 hsa-miR-140-5p CUEDC1 -0.76 0 0.54 0 PITA; miRanda -0.19 0 NA
62 hsa-miR-140-5p CXXC4 -0.76 0 -0.35 0.08009 miRanda -0.13 0.04681 NA
63 hsa-miR-140-5p CYB5D1 -0.76 0 -0.14 0.07571 miRanda -0.15 0 NA
64 hsa-miR-140-5p CYTH2 -0.76 0 0.7 0 MirTarget; miRanda; miRNATAP -0.27 0 NA
65 hsa-miR-140-5p DCDC1 -0.76 0 0.96 5.0E-5 PITA; miRanda -0.52 0 NA
66 hsa-miR-140-5p DCDC2 -0.76 0 -1.86 0 miRanda -0.2 0.0478 NA
67 hsa-miR-140-5p DHCR24 -0.76 0 0.77 0 miRanda -0.32 0 NA
68 hsa-miR-140-5p DHRS4L1 -0.76 0 -0.1 0.44303 miRanda -0.21 0 NA
69 hsa-miR-140-5p DNAH14 -0.76 0 1.8 0 miRanda -0.21 0 NA
70 hsa-miR-140-5p DNAH7 -0.76 0 -0.38 0.0511 miRanda -0.32 0 NA
71 hsa-miR-140-5p DNAJA4 -0.76 0 0.78 0 miRanda -0.22 0 NA
72 hsa-miR-140-5p DNMBP -0.76 0 -0.67 0 miRanda -0.1 0.01111 NA
73 hsa-miR-140-5p DNPEP -0.76 0 0.47 0 miRNAWalker2 validate; miRTarBase -0.16 0 NA
74 hsa-miR-140-5p DPP9 -0.76 0 0.84 0 miRanda -0.19 0 NA
75 hsa-miR-140-5p DUSP16 -0.76 0 -0 0.97223 miRNATAP -0.17 0 NA
76 hsa-miR-140-5p EARS2 -0.76 0 0.69 0 miRanda -0.2 0 NA
77 hsa-miR-140-5p ECHDC2 -0.76 0 -0.58 0 miRanda -0.16 1.0E-5 NA
78 hsa-miR-140-5p ECM1 -0.76 0 1.1 0 miRanda -0.31 0 NA
79 hsa-miR-140-5p EFCAB2 -0.76 0 -0.08 0.43842 miRanda -0.14 4.0E-5 NA
80 hsa-miR-140-5p EFHC2 -0.76 0 0.35 0.08676 miRanda -0.18 0.00997 NA
81 hsa-miR-140-5p EFNA4 -0.76 0 1.37 0 PITA; miRanda -0.17 0.0001 NA
82 hsa-miR-140-5p EFR3B -0.76 0 0.73 0 miRanda -0.14 0.00814 NA
83 hsa-miR-140-5p EGLN3 -0.76 0 1.25 0 miRanda -0.31 0 NA
84 hsa-miR-140-5p EHMT2 -0.76 0 0.76 0 miRanda -0.13 0 NA
85 hsa-miR-140-5p ELOVL2 -0.76 0 0.23 0.46728 miRanda -0.41 8.0E-5 NA
86 hsa-miR-140-5p ELOVL5 -0.76 0 -0.3 0.02147 miRanda -0.14 0.00126 NA
87 hsa-miR-140-5p ENOSF1 -0.76 0 -0.05 0.53098 miRanda -0.1 9.0E-5 NA
88 hsa-miR-140-5p ENPP5 -0.76 0 0.73 0.00025 miRanda -0.37 0 NA
89 hsa-miR-140-5p ENSA -0.76 0 0.72 0 PITA -0.18 0 NA
90 hsa-miR-140-5p ENTPD5 -0.76 0 -0.34 0.01596 MirTarget; miRanda -0.15 0.00128 NA
91 hsa-miR-140-5p EPB41L4A -0.76 0 -0.67 0 miRanda -0.14 0.00095 NA
92 hsa-miR-140-5p EPN2 -0.76 0 -0.03 0.69538 miRanda -0.12 0 NA
93 hsa-miR-140-5p ERBB4 -0.76 0 -0.95 0.00612 PITA -0.68 0 NA
94 hsa-miR-140-5p ERI2 -0.76 0 0.37 1.0E-5 miRanda -0.2 0 NA
95 hsa-miR-140-5p EVPL -0.76 0 2.22 0 miRanda -0.41 0 NA
96 hsa-miR-140-5p EXOC6 -0.76 0 0.31 0.00088 miRanda -0.2 0 NA
97 hsa-miR-140-5p FAHD1 -0.76 0 0.78 0 miRanda -0.19 0 NA
98 hsa-miR-140-5p FAM102A -0.76 0 1.24 0 PITA; miRanda; miRNATAP -0.31 0 NA
99 hsa-miR-140-5p FAM134A -0.76 0 0.26 0 miRanda -0.1 0 NA
100 hsa-miR-140-5p FAM189A1 -0.76 0 0.34 0.19931 miRanda -0.23 0.0088 NA
101 hsa-miR-140-5p FKBP10 -0.76 0 1.22 0 miRanda -0.28 0 NA
102 hsa-miR-140-5p FKBP4 -0.76 0 1.52 0 miRanda; miRNATAP -0.36 0 NA
103 hsa-miR-140-5p FLVCR1 -0.76 0 1.31 0 miRanda -0.16 1.0E-5 NA
104 hsa-miR-140-5p FNIP1 -0.76 0 -0.24 0.00277 miRanda -0.1 0.00018 NA
105 hsa-miR-140-5p FRS2 -0.76 0 -0.15 0.1727 PITA; miRanda -0.11 0.00361 NA
106 hsa-miR-140-5p FSTL4 -0.76 0 1.62 0 miRanda -0.58 0 NA
107 hsa-miR-140-5p GALNT6 -0.76 0 1.53 0 miRanda -0.71 0 NA
108 hsa-miR-140-5p GAS8 -0.76 0 0.32 3.0E-5 miRanda -0.11 1.0E-5 NA
109 hsa-miR-140-5p GATA3 -0.76 0 1.56 0 PITA; miRanda -0.91 0 NA
110 hsa-miR-140-5p GCM1 -0.76 0 0.36 0.13457 miRanda -0.33 3.0E-5 NA
111 hsa-miR-140-5p GDE1 -0.76 0 0.35 0 miRanda -0.14 0 NA
112 hsa-miR-140-5p GIGYF1 -0.76 0 0.13 0.12556 miRanda -0.16 0 NA
113 hsa-miR-140-5p GINS1 -0.76 0 2.31 0 MirTarget; miRanda -0.11 0.01786 NA
114 hsa-miR-140-5p GLI3 -0.76 0 -0.34 0.01072 PITA; miRanda -0.28 0 NA
115 hsa-miR-140-5p GLRX5 -0.76 0 0.41 0 miRanda; miRNATAP -0.13 0 NA
116 hsa-miR-140-5p GLS2 -0.76 0 0.14 0.43815 miRanda -0.36 0 NA
117 hsa-miR-140-5p GLUL -0.76 0 0.09 0.39345 miRanda -0.19 0 NA
118 hsa-miR-140-5p GNPTG -0.76 0 0.44 0 miRanda -0.22 0 NA
119 hsa-miR-140-5p GPD1L -0.76 0 -0.94 0 miRanda -0.14 0.00032 NA
120 hsa-miR-140-5p GRIK4 -0.76 0 0.9 0.00051 miRanda -0.62 0 NA
121 hsa-miR-140-5p GRIPAP1 -0.76 0 0.58 0 miRanda -0.15 0 NA
122 hsa-miR-140-5p HDAC7 -0.76 0 -0.1 0.10388 miRanda; miRNATAP -0.15 0 NA
123 hsa-miR-140-5p HDC -0.76 0 -0.97 0.00011 miRanda -0.36 1.0E-5 NA
124 hsa-miR-140-5p HMGCL -0.76 0 0.12 0.0987 miRanda -0.14 0 NA
125 hsa-miR-140-5p HMGN1 -0.76 0 0.99 0 miRanda -0.13 0 NA
126 hsa-miR-140-5p HNRNPM -0.76 0 0.54 0 miRanda -0.12 0 NA
127 hsa-miR-140-5p HOMEZ -0.76 0 0.25 0.00053 miRanda -0.19 0 NA
128 hsa-miR-140-5p HOPX -0.76 0 1.12 0 miRanda -0.14 0.00126 NA
129 hsa-miR-140-5p HOXB3 -0.76 0 -0.09 0.64242 miRanda -0.34 0 NA
130 hsa-miR-140-5p IGF1R -0.76 0 0.12 0.48217 PITA; miRNATAP -0.15 0.00807 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC
131 hsa-miR-140-5p IGFBP2 -0.76 0 0.6 0.0011 miRanda -0.41 0 NA
132 hsa-miR-140-5p IGSF3 -0.76 0 0.89 0 MirTarget; PITA; miRanda; miRNATAP -0.11 0.00365 NA
133 hsa-miR-140-5p IKBKG -0.76 0 0.49 0 miRanda -0.13 0 NA
134 hsa-miR-140-5p IL11 -0.76 0 2.05 0 miRanda -0.29 0 NA
135 hsa-miR-140-5p IPPK -0.76 0 0.76 0 miRanda -0.13 0 NA
136 hsa-miR-140-5p IQCE -0.76 0 0.74 0 mirMAP -0.2 0 NA
137 hsa-miR-140-5p IQCH -0.76 0 0.32 0.00965 miRanda -0.28 0 NA
138 hsa-miR-140-5p IYD -0.76 0 1.08 0.00195 miRanda -0.52 1.0E-5 NA
139 hsa-miR-140-5p KCNC1 -0.76 0 -0.42 0.12578 miRanda -0.31 0.00065 NA
140 hsa-miR-140-5p KCNJ3 -0.76 0 1.14 0.02149 miRanda -0.73 1.0E-5 NA
141 hsa-miR-140-5p KCNK6 -0.76 0 1.3 0 miRanda -0.38 0 NA
142 hsa-miR-140-5p KCTD11 -0.76 0 0.11 0.07227 miRanda -0.12 0 NA
143 hsa-miR-140-5p KCTD3 -0.76 0 0.42 4.0E-5 miRanda -0.21 0 NA
144 hsa-miR-140-5p KIAA0040 -0.76 0 0.37 0.00181 MirTarget; miRanda -0.24 0 NA
145 hsa-miR-140-5p KIF3A -0.76 0 0.22 0.01171 miRanda -0.14 0 NA
146 hsa-miR-140-5p KIF4A -0.76 0 4.44 0 miRanda -0.23 0.00174 NA
147 hsa-miR-140-5p KSR2 -0.76 0 -0.09 0.65861 mirMAP -0.31 0 NA
148 hsa-miR-140-5p LINGO4 -0.76 0 0.12 0.55551 miRanda -0.25 0.0002 NA
149 hsa-miR-140-5p LNX2 -0.76 0 0.33 9.0E-5 miRanda -0.13 0 NA
150 hsa-miR-140-5p LRBA -0.76 0 0.32 0.00275 miRanda -0.21 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Peroxisome_hsa04146 5 83 0.01096 0.3173
2 Apoptosis_multiple_species_hsa04215 3 33 0.01579 0.3173
3 p53_signaling_pathway_hsa04115 4 68 0.024 0.3173
4 Apoptosis_hsa04210 6 138 0.02441 0.3173
5 Hedgehog_signaling_pathway_hsa04340 3 47 0.03985 0.3737
6 cGMP_PKG_signaling_pathway_hsa04022 6 163 0.04867 0.3737
7 Oocyte_meiosis_hsa04114 5 124 0.05031 0.3737
8 Hippo_signaling_pathway_hsa04390 5 154 0.1037 0.6302
9 AMPK_signaling_pathway_hsa04152 4 121 0.1316 0.6302
10 Gap_junction_hsa04540 3 88 0.1691 0.6302
11 Ras_signaling_pathway_hsa04014 6 232 0.1724 0.6302
12 NF_kappa_B_signaling_pathway_hsa04064 3 95 0.1973 0.6302
13 MAPK_signaling_pathway_hsa04010 7 295 0.1995 0.6302
14 Endocytosis_hsa04144 6 244 0.2014 0.6302
15 PI3K_Akt_signaling_pathway_hsa04151 8 352 0.2087 0.6302
16 Wnt_signaling_pathway_hsa04310 4 146 0.2094 0.6302
17 cAMP_signaling_pathway_hsa04024 5 198 0.2153 0.6302
18 HIF_1_signaling_pathway_hsa04066 3 100 0.2181 0.6302
19 Rap1_signaling_pathway_hsa04015 5 206 0.2387 0.638
20 TNF_signaling_pathway_hsa04668 3 108 0.2523 0.638
21 Cellular_senescence_hsa04218 4 160 0.2576 0.638
22 Tight_junction_hsa04530 4 170 0.2933 0.6799
23 Lysosome_hsa04142 3 123 0.3179 0.6799
24 Adherens_junction_hsa04520 2 72 0.3231 0.6799
25 Calcium_signaling_pathway_hsa04020 4 182 0.3369 0.6799
26 Autophagy_animal_hsa04140 3 128 0.3399 0.6799
27 FoxO_signaling_pathway_hsa04068 3 132 0.3575 0.6886
28 Apelin_signaling_pathway_hsa04371 3 137 0.3794 0.696
29 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 3 139 0.3882 0.696
30 Phospholipase_D_signaling_pathway_hsa04072 3 146 0.4184 0.7018
31 mTOR_signaling_pathway_hsa04150 3 151 0.4397 0.7145
32 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.4751 0.7487
33 Necroptosis_hsa04217 3 164 0.4936 0.7549
34 Cell_cycle_hsa04110 2 124 0.596 0.861
35 Jak_STAT_signaling_pathway_hsa04630 2 162 0.7379 0.9738
36 Cytokine_cytokine_receptor_interaction_hsa04060 2 270 0.9336 1
37 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.9403 1

Quest ID: 01ae5256d9f7c5b6b4015cb47f10ab52