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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-125a-5p ABHD3 0.6 0.01023 0.98 0 PITA; miRanda -0.1 0.01012 NA
2 hsa-miR-125a-5p ABL2 0.6 0.01023 -0.32 0.04554 MirTarget; PITA -0.22 0 26766902 MicroRNA 125a 5p modulates human cervical carcinoma proliferation and migration by targeting ABL2; The direct regulation of miR-125a-5p on its target gene ABL proto-oncogene 2 ABL2 in cervical carcinoma was evaluated by quantitative real-time reverse transcription polymerase chain reaction Western blotting and luciferase reporter assays respectively; ABL2 was shown to be directly targeted by miR-125a-5p; In cervical carcinoma ABL2 gene and protein levels were both downregulated by miR-125a-5p
3 hsa-miR-125a-5p ACAT1 0.6 0.01023 -1.05 0 miRanda -0.26 0 NA
4 hsa-miR-125a-5p ACTBL2 0.6 0.01023 1.68 0.00368 miRanda -0.67 0 NA
5 hsa-miR-125a-5p ACTG2 0.6 0.01023 -5.39 0 miRanda -0.51 0.00044 NA
6 hsa-miR-125a-5p ADAM19 0.6 0.01023 -1.06 0.01895 mirMAP -0.65 0 NA
7 hsa-miR-125a-5p ADAMTS14 0.6 0.01023 0.61 0.12479 miRanda; mirMAP -0.23 0.00478 NA
8 hsa-miR-125a-5p ADAMTS15 0.6 0.01023 -2.81 0 mirMAP -0.81 0 NA
9 hsa-miR-125a-5p ADARB1 0.6 0.01023 -1.93 0 mirMAP -0.26 7.0E-5 NA
10 hsa-miR-125a-5p ADCY9 0.6 0.01023 -1.5 0 mirMAP -0.32 0 NA
11 hsa-miR-125a-5p ADD2 0.6 0.01023 -0.72 0.25015 MirTarget; miRanda -0.88 0 NA
12 hsa-miR-125a-5p ADM2 0.6 0.01023 2.23 0 mirMAP -0.21 0.0146 NA
13 hsa-miR-125a-5p ADPRH 0.6 0.01023 -0.71 0.00334 miRanda -0.21 3.0E-5 NA
14 hsa-miR-125a-5p ADRB3 0.6 0.01023 -5.02 0 miRanda -0.38 0.00257 NA
15 hsa-miR-125a-5p AEN 0.6 0.01023 -0.36 0.01541 miRanda -0.12 0.00013 NA
16 hsa-miR-125a-5p AFAP1L2 0.6 0.01023 0.06 0.85809 miRanda -0.14 0.03234 NA
17 hsa-miR-125a-5p AGPAT4 0.6 0.01023 -0.79 0.01174 miRanda -0.26 9.0E-5 NA
18 hsa-miR-125a-5p AGTRAP 0.6 0.01023 0.96 0 miRNAWalker2 validate; miRanda -0.1 0.01113 NA
19 hsa-miR-125a-5p AKAP11 0.6 0.01023 -0.8 0 miRanda -0.1 0.00318 NA
20 hsa-miR-125a-5p AKAP13 0.6 0.01023 -1.15 0 miRanda -0.18 0 NA
21 hsa-miR-125a-5p ALDH1A3 0.6 0.01023 -1.34 0.0022 miRanda -0.29 0.0018 NA
22 hsa-miR-125a-5p ALDH6A1 0.6 0.01023 -0.99 1.0E-5 miRanda -0.13 0.00722 NA
23 hsa-miR-125a-5p ANKH 0.6 0.01023 -0.38 0.21654 mirMAP -0.21 0.00143 NA
24 hsa-miR-125a-5p ANKRD29 0.6 0.01023 -3.47 0 MirTarget; miRanda -0.86 0 NA
25 hsa-miR-125a-5p ANKRD44 0.6 0.01023 -1.93 0 miRanda -0.48 0 NA
26 hsa-miR-125a-5p ANKS6 0.6 0.01023 0.1 0.68568 MirTarget -0.23 1.0E-5 NA
27 hsa-miR-125a-5p ANPEP 0.6 0.01023 -0.91 0.0551 PITA; miRanda; miRNATAP -0.29 0.00316 NA
28 hsa-miR-125a-5p ANTXR2 0.6 0.01023 -2.31 0 PITA -0.27 5.0E-5 NA
29 hsa-miR-125a-5p APC 0.6 0.01023 -0.6 0.00012 miRanda -0.21 0 NA
30 hsa-miR-125a-5p API5 0.6 0.01023 -0.2 0.06111 miRanda -0.15 0 NA
31 hsa-miR-125a-5p ARHGAP11B 0.6 0.01023 2.25 0 miRanda -0.25 0.00065 NA
32 hsa-miR-125a-5p ARHGAP25 0.6 0.01023 -0.72 0.00654 miRanda -0.19 0.00049 NA
33 hsa-miR-125a-5p ARL10 0.6 0.01023 -1.12 0.00198 mirMAP -0.46 0 NA
34 hsa-miR-125a-5p ARNTL 0.6 0.01023 -0.36 0.08956 miRanda -0.21 0 NA
35 hsa-miR-125a-5p ARSI 0.6 0.01023 -1.42 0.02177 MirTarget; miRanda -0.92 0 NA
36 hsa-miR-125a-5p ASB2 0.6 0.01023 -3.86 0 miRanda -0.65 0 NA
37 hsa-miR-125a-5p ATL2 0.6 0.01023 -0.08 0.64926 miRNAWalker2 validate; miRanda -0.2 0 NA
38 hsa-miR-125a-5p ATP10D 0.6 0.01023 -0.69 0.01004 MirTarget; miRanda -0.26 0 NA
39 hsa-miR-125a-5p ATP6V1B2 0.6 0.01023 -0.17 0.24474 miRanda -0.17 0 NA
40 hsa-miR-125a-5p ATP8B2 0.6 0.01023 -1.89 0 MirTarget -0.39 0 NA
41 hsa-miR-125a-5p ATP8B4 0.6 0.01023 -1.9 0 miRanda -0.38 0 NA
42 hsa-miR-125a-5p ATXN1 0.6 0.01023 -1.51 0 miRNAWalker2 validate; MirTarget; PITA; miRNATAP -0.3 0 NA
43 hsa-miR-125a-5p B2M 0.6 0.01023 -0 0.98848 miRanda -0.2 0.00015 NA
44 hsa-miR-125a-5p B3GALNT2 0.6 0.01023 -0.6 0 MirTarget; miRanda; miRNATAP -0.15 0 NA
45 hsa-miR-125a-5p B4GALNT1 0.6 0.01023 -0.59 0.29462 miRanda -0.84 0 NA
46 hsa-miR-125a-5p BACE1 0.6 0.01023 -0.72 0.00096 mirMAP -0.18 6.0E-5 NA
47 hsa-miR-125a-5p BAG4 0.6 0.01023 0.14 0.55811 MirTarget -0.16 0.00089 NA
48 hsa-miR-125a-5p BAK1 0.6 0.01023 0.76 0.00013 miRNAWalker2 validate; PITA; miRanda; miRNATAP -0.1 0.01351 NA
49 hsa-miR-125a-5p BATF2 0.6 0.01023 0.06 0.89203 miRanda -0.39 4.0E-5 NA
50 hsa-miR-125a-5p BAZ1A 0.6 0.01023 0.41 0.01012 miRanda -0.11 0.00058 NA
51 hsa-miR-125a-5p BCAT1 0.6 0.01023 0.31 0.53319 MirTarget -0.49 0 NA
52 hsa-miR-125a-5p BCL2 0.6 0.01023 -2.02 0 PITA -0.2 0.00065 NA
53 hsa-miR-125a-5p BEND6 0.6 0.01023 -0.8 0.03128 miRanda -0.35 0 NA
54 hsa-miR-125a-5p BIN2 0.6 0.01023 -0.82 0.04018 miRanda; miRNATAP -0.38 1.0E-5 NA
55 hsa-miR-125a-5p BLZF1 0.6 0.01023 -0.38 0.01298 miRanda -0.17 0 NA
56 hsa-miR-125a-5p BMP1 0.6 0.01023 0.19 0.45337 mirMAP -0.14 0.01248 NA
57 hsa-miR-125a-5p BMPR1B 0.6 0.01023 0.07 0.91404 MirTarget; miRNATAP -0.81 0 NA
58 hsa-miR-125a-5p BRCC3 0.6 0.01023 0.16 0.30814 miRanda -0.13 5.0E-5 NA
59 hsa-miR-125a-5p BRD3 0.6 0.01023 -0.16 0.29566 miRanda -0.12 0.00013 NA
60 hsa-miR-125a-5p BTC 0.6 0.01023 -1.9 8.0E-5 miRanda -0.27 0.00787 NA
61 hsa-miR-125a-5p C2 0.6 0.01023 0.19 0.65465 miRanda -0.23 0.00866 NA
62 hsa-miR-125a-5p CACNA1B 0.6 0.01023 0.25 0.68303 MirTarget; miRanda; miRNATAP -0.28 0.03205 NA
63 hsa-miR-125a-5p CAMK2A 0.6 0.01023 -4.14 0 mirMAP -0.75 0 NA
64 hsa-miR-125a-5p CAND2 0.6 0.01023 -1.77 1.0E-5 miRanda -0.22 0.01091 NA
65 hsa-miR-125a-5p CAPZA2 0.6 0.01023 -0.83 0 miRanda -0.11 3.0E-5 NA
66 hsa-miR-125a-5p CBX6 0.6 0.01023 -1.54 0 mirMAP -0.16 0.01253 NA
67 hsa-miR-125a-5p CCDC91 0.6 0.01023 -0.41 0.01203 miRanda -0.12 0.00036 NA
68 hsa-miR-125a-5p CCL5 0.6 0.01023 -0.09 0.86108 miRNAWalker2 validate -0.27 0.0115 NA
69 hsa-miR-125a-5p CCR2 0.6 0.01023 -0.81 0.0912 miRanda -0.24 0.01723 NA
70 hsa-miR-125a-5p CCR5 0.6 0.01023 -0.51 0.25508 miRanda -0.45 0 NA
71 hsa-miR-125a-5p CD244 0.6 0.01023 -0.75 0.11701 miRanda -0.23 0.02134 NA
72 hsa-miR-125a-5p CD248 0.6 0.01023 -1.89 0 PITA; miRanda; miRNATAP -0.23 0.00215 NA
73 hsa-miR-125a-5p CD300LF 0.6 0.01023 0.49 0.24436 miRNATAP -0.42 0 NA
74 hsa-miR-125a-5p CD69 0.6 0.01023 -2.49 0 miRanda -0.32 0.00232 NA
75 hsa-miR-125a-5p CD72 0.6 0.01023 0.23 0.52819 miRanda -0.19 0.01392 NA
76 hsa-miR-125a-5p CD84 0.6 0.01023 -0.53 0.27947 miRanda -0.67 0 NA
77 hsa-miR-125a-5p CD8A 0.6 0.01023 -0.72 0.14726 miRanda -0.51 0 NA
78 hsa-miR-125a-5p CDA 0.6 0.01023 0.13 0.79951 miRanda -0.43 2.0E-5 NA
79 hsa-miR-125a-5p CDK17 0.6 0.01023 -0.52 0.00027 miRanda -0.13 1.0E-5 NA
80 hsa-miR-125a-5p CDK5RAP2 0.6 0.01023 -0.43 0.00431 miRanda -0.2 0 NA
81 hsa-miR-125a-5p CDKN2B 0.6 0.01023 -0.11 0.83235 miRanda -0.31 0.00518 NA
82 hsa-miR-125a-5p CEACAM21 0.6 0.01023 -0.15 0.72613 miRanda -0.39 1.0E-5 NA
83 hsa-miR-125a-5p CELF1 0.6 0.01023 -0.3 0.01785 mirMAP -0.15 0 NA
84 hsa-miR-125a-5p CENPO 0.6 0.01023 1.82 0 mirMAP -0.14 0.0013 NA
85 hsa-miR-125a-5p CFLAR 0.6 0.01023 -0.23 0.20284 miRanda -0.23 0 NA
86 hsa-miR-125a-5p CGREF1 0.6 0.01023 1.54 0.00763 MirTarget; miRanda -0.37 0.00191 NA
87 hsa-miR-125a-5p CHD1 0.6 0.01023 -0.57 4.0E-5 miRanda -0.13 1.0E-5 NA
88 hsa-miR-125a-5p CHRM3 0.6 0.01023 -2.48 3.0E-5 miRanda -0.6 0 NA
89 hsa-miR-125a-5p CHRNB2 0.6 0.01023 0.9 0.02654 mirMAP -0.26 0.0024 NA
90 hsa-miR-125a-5p CKS1B 0.6 0.01023 1.72 0 miRanda -0.13 0.00687 NA
91 hsa-miR-125a-5p CLEC2B 0.6 0.01023 -0.84 0.04958 miRanda -0.39 1.0E-5 NA
92 hsa-miR-125a-5p CNNM1 0.6 0.01023 -3.31 0 PITA; miRanda -0.44 0.00016 NA
93 hsa-miR-125a-5p CNTLN 0.6 0.01023 -1.17 0.00322 miRanda -0.54 0 NA
94 hsa-miR-125a-5p COL14A1 0.6 0.01023 -3.66 0 miRanda -0.23 0.01682 NA
95 hsa-miR-125a-5p COL1A2 0.6 0.01023 -0.91 0.05362 miRanda -0.32 0.00107 NA
96 hsa-miR-125a-5p COL4A1 0.6 0.01023 0.15 0.58169 miRNAWalker2 validate; miRanda -0.2 0.00057 NA
97 hsa-miR-125a-5p CORO1C 0.6 0.01023 -1.12 0 miRNAWalker2 validate -0.41 0 NA
98 hsa-miR-125a-5p CPT1A 0.6 0.01023 -0.83 0.00093 miRanda -0.21 4.0E-5 NA
99 hsa-miR-125a-5p CR1 0.6 0.01023 -1.99 0.00029 miRanda -0.65 0 NA
100 hsa-miR-125a-5p CREB5 0.6 0.01023 -2.28 0 miRNAWalker2 validate -0.53 0 NA
101 hsa-miR-125a-5p CREM 0.6 0.01023 -1.35 0 miRanda -0.1 0.00724 NA
102 hsa-miR-125a-5p CRK 0.6 0.01023 -0.6 4.0E-5 miRNAWalker2 validate -0.13 1.0E-5 NA
103 hsa-miR-125a-5p CSF1 0.6 0.01023 -1.3 0.00033 mirMAP -0.4 0 NA
104 hsa-miR-125a-5p CSF2RB 0.6 0.01023 -0.74 0.0696 miRanda -0.43 0 NA
105 hsa-miR-125a-5p CTH 0.6 0.01023 -0.02 0.95595 miRanda -0.19 0.00571 NA
106 hsa-miR-125a-5p CXCL13 0.6 0.01023 0.84 0.29157 miRanda -0.99 0 NA
107 hsa-miR-125a-5p CYB5R4 0.6 0.01023 -0.07 0.6698 miRanda -0.15 0 NA
108 hsa-miR-125a-5p CYBB 0.6 0.01023 -0.86 0.06319 miRanda -0.61 0 NA
109 hsa-miR-125a-5p CYTH3 0.6 0.01023 -0.27 0.19343 mirMAP -0.22 0 NA
110 hsa-miR-125a-5p CYTH4 0.6 0.01023 -0.8 0.05153 miRanda -0.47 0 NA
111 hsa-miR-125a-5p DAAM1 0.6 0.01023 -0.94 0.00028 MirTarget -0.36 0 NA
112 hsa-miR-125a-5p DCAF10 0.6 0.01023 -0.23 0.06446 MirTarget -0.14 0 NA
113 hsa-miR-125a-5p DCLK1 0.6 0.01023 -3.63 0 miRanda -0.68 0 NA
114 hsa-miR-125a-5p DCTN1 0.6 0.01023 -0.35 0.00097 miRNATAP -0.1 0 NA
115 hsa-miR-125a-5p DHFR 0.6 0.01023 0.46 0.02432 miRanda -0.18 3.0E-5 NA
116 hsa-miR-125a-5p DHX33 0.6 0.01023 0.22 0.41826 MirTarget; miRNATAP -0.22 0.0001 NA
117 hsa-miR-125a-5p DIAPH3 0.6 0.01023 2.49 0 miRanda -0.38 0 NA
118 hsa-miR-125a-5p DIRAS1 0.6 0.01023 -3.19 0 PITA; miRanda -0.4 0.00133 NA
119 hsa-miR-125a-5p DLD 0.6 0.01023 -0.32 0.01112 MirTarget; miRanda -0.11 2.0E-5 NA
120 hsa-miR-125a-5p DMC1 0.6 0.01023 -0.83 0.06436 miRanda -0.35 0.00016 NA
121 hsa-miR-125a-5p DNAH11 0.6 0.01023 0.65 0.31423 miRanda -0.61 1.0E-5 NA
122 hsa-miR-125a-5p DNAJB5 0.6 0.01023 -2.65 0 miRanda; miRNATAP -0.54 0 NA
123 hsa-miR-125a-5p DOCK11 0.6 0.01023 -1.8 0 miRanda -0.5 0 NA
124 hsa-miR-125a-5p DPF3 0.6 0.01023 -1.67 1.0E-5 mirMAP -0.45 0 NA
125 hsa-miR-125a-5p DPP4 0.6 0.01023 -0.61 0.28445 miRanda -0.63 0 NA
126 hsa-miR-125a-5p DPY19L2P2 0.6 0.01023 -1.08 0.00966 miRanda -0.33 0.00011 NA
127 hsa-miR-125a-5p DPYD 0.6 0.01023 -1.71 0.00028 miRanda -0.63 0 NA
128 hsa-miR-125a-5p DPYSL3 0.6 0.01023 -2.32 0 miRanda -0.5 0 NA
129 hsa-miR-125a-5p DRP2 0.6 0.01023 -1.35 0.00023 MirTarget -0.3 0.0001 NA
130 hsa-miR-125a-5p DST 0.6 0.01023 -1.12 9.0E-5 mirMAP -0.17 0.00446 NA
131 hsa-miR-125a-5p DSTN 0.6 0.01023 -1.58 0 miRanda -0.17 0 NA
132 hsa-miR-125a-5p DTNA 0.6 0.01023 -4.06 0 miRanda -0.72 0 NA
133 hsa-miR-125a-5p DUSP3 0.6 0.01023 -1.04 0 miRNAWalker2 validate -0.19 0 NA
134 hsa-miR-125a-5p DUSP7 0.6 0.01023 0.25 0.41555 miRanda -0.25 8.0E-5 NA
135 hsa-miR-125a-5p E2F2 0.6 0.01023 2.71 0 MirTarget -0.3 2.0E-5 NA
136 hsa-miR-125a-5p E2F7 0.6 0.01023 2.72 0 miRNAWalker2 validate -0.22 0.00336 NA
137 hsa-miR-125a-5p ECE1 0.6 0.01023 -0.29 0.08009 mirMAP -0.14 6.0E-5 NA
138 hsa-miR-125a-5p ECE2 0.6 0.01023 1.99 0 miRanda -0.15 0.00145 NA
139 hsa-miR-125a-5p EGFR 0.6 0.01023 -0.23 0.5939 mirMAP -0.46 0 19881956; 27094723; 24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML
140 hsa-miR-125a-5p EGR3 0.6 0.01023 -4.25 0 PITA -0.45 0 NA
141 hsa-miR-125a-5p EIF4H 0.6 0.01023 -0.23 0.02542 miRanda -0.13 0 NA
142 hsa-miR-125a-5p EIF5A2 0.6 0.01023 -1.12 0.00497 PITA; miRanda -0.66 0 NA
143 hsa-miR-125a-5p ELOVL4 0.6 0.01023 -0.9 0.05961 miRanda -0.76 0 NA
144 hsa-miR-125a-5p EMILIN2 0.6 0.01023 -0.48 0.11275 miRanda -0.17 0.00849 NA
145 hsa-miR-125a-5p ENKUR 0.6 0.01023 1.45 0.00183 miRanda -0.48 0 NA
146 hsa-miR-125a-5p ENO1 0.6 0.01023 0.86 0 miRNAWalker2 validate -0.15 9.0E-5 NA
147 hsa-miR-125a-5p ENPEP 0.6 0.01023 -0.33 0.36616 PITA; miRanda -0.32 2.0E-5 NA
148 hsa-miR-125a-5p ENTPD1 0.6 0.01023 -1.12 0 miRanda -0.21 0 NA
149 hsa-miR-125a-5p EPHA6 0.6 0.01023 -3.76 0 miRanda -0.64 0 NA
150 hsa-miR-125a-5p EPM2A 0.6 0.01023 -1.9 0 miRanda -0.2 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 IMMUNE SYSTEM PROCESS 103 1984 4.086e-09 1.901e-05
2 POSITIVE REGULATION OF MOLECULAR FUNCTION 91 1791 1.058e-07 0.0002462
3 POSITIVE REGULATION OF RESPONSE TO STIMULUS 94 1929 4.263e-07 0.0004981
4 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 91 1848 4.282e-07 0.0004981
5 POSITIVE REGULATION OF CATALYTIC ACTIVITY 77 1518 1.246e-06 0.0008282
6 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 68 1275 9.951e-07 0.0008282
7 RESPONSE TO CYTOKINE 45 714 1.116e-06 0.0008282
8 RESPONSE TO OXYGEN CONTAINING COMPOUND 71 1381 2.114e-06 0.001229
9 CYTOKINE MEDIATED SIGNALING PATHWAY 32 452 3.94e-06 0.001634
10 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 80 1656 4.894e-06 0.001634
11 DEFENSE RESPONSE 64 1231 4.916e-06 0.001634
12 INTRACELLULAR SIGNAL TRANSDUCTION 77 1572 4.577e-06 0.001634
13 REGULATION OF IMMUNE SYSTEM PROCESS 71 1403 3.684e-06 0.001634
14 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 56 1021 4.234e-06 0.001634
15 ACTIN FILAMENT BASED PROCESS 31 450 9.627e-06 0.002986
16 ANTIGEN PROCESSING AND PRESENTATION 19 213 1.643e-05 0.004498
17 RESPONSE TO PROTOZOAN 6 20 1.635e-05 0.004498
18 REGULATION OF HYDROLASE ACTIVITY 65 1327 2.72e-05 0.005274
19 REGULATION OF IMMUNE RESPONSE 47 858 2.663e-05 0.005274
20 POSITIVE REGULATION OF HYDROLASE ACTIVITY 49 905 2.417e-05 0.005274
21 LYMPHOCYTE ACTIVATION 25 342 2.627e-05 0.005274
22 LOCOMOTION 57 1114 2.639e-05 0.005274
23 CELLULAR RESPONSE TO CYTOKINE STIMULUS 37 606 2.049e-05 0.005274
24 BIOLOGICAL ADHESION 54 1032 2.372e-05 0.005274
25 CENTRAL NERVOUS SYSTEM PROJECTION NEURON AXONOGENESIS 6 22 2.995e-05 0.005574
26 LEUKOCYTE ACTIVATION 28 414 3.585e-05 0.005892
27 POSITIVE REGULATION OF CELL COMMUNICATION 72 1532 3.792e-05 0.005892
28 SINGLE ORGANISM CELL ADHESION 30 459 3.606e-05 0.005892
29 INTERFERON GAMMA MEDIATED SIGNALING PATHWAY 10 70 3.374e-05 0.005892
30 REGULATION OF CELLULAR COMPONENT MOVEMENT 43 771 3.895e-05 0.005892
31 REGULATION OF GTPASE ACTIVITY 39 673 3.925e-05 0.005892
32 REGULATION OF CALCIUM ION TRANSPORT 18 209 4.346e-05 0.00632
33 IMMUNE SYSTEM DEVELOPMENT 35 582 4.66e-05 0.00657
34 HOMEOSTATIC PROCESS 64 1337 6.227e-05 0.007935
35 CELL ACTIVATION 34 568 6.537e-05 0.007935
36 ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN 16 177 6.422e-05 0.007935
37 RESPONSE TO ENDOGENOUS STIMULUS 68 1450 6.768e-05 0.007935
38 IMMUNE RESPONSE 55 1100 6.822e-05 0.007935
39 CARDIOVASCULAR SYSTEM DEVELOPMENT 43 788 6.425e-05 0.007935
40 CIRCULATORY SYSTEM DEVELOPMENT 43 788 6.425e-05 0.007935
41 RESPONSE TO INTERFERON GAMMA 14 144 8.33e-05 0.009229
42 REGULATION OF PROTEIN MODIFICATION PROCESS 77 1710 8.27e-05 0.009229
NumGOOverlapSizeP ValueAdj. P Value
1 MOLECULAR FUNCTION REGULATOR 71 1353 1.013e-06 0.0009413
2 ENZYME BINDING 84 1737 2.63e-06 0.001221
3 ACTIN BINDING 28 393 1.403e-05 0.004346
4 CYTOSKELETAL PROTEIN BINDING 45 819 3.685e-05 0.008558
5 CYTOKINE RECEPTOR ACTIVITY 11 89 5.48e-05 0.009105
6 GTPASE BINDING 22 295 5.88e-05 0.009105
NumGOOverlapSizeP ValueAdj. P Value
1 PLASMA MEMBRANE PROTEIN COMPLEX 36 510 1.051e-06 0.000614
2 CELL SURFACE 46 757 2.28e-06 0.0006659
3 INTRINSIC COMPONENT OF PLASMA MEMBRANE 77 1649 2.473e-05 0.004814
4 SIDE OF MEMBRANE 28 428 6.416e-05 0.009367

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04612_Antigen_processing_and_presentation 11 78 1.558e-05 0.002804
2 hsa04630_Jak.STAT_signaling_pathway 14 155 0.0001829 0.01646
3 hsa04380_Osteoclast_differentiation 12 128 0.0003694 0.02216
4 hsa04640_Hematopoietic_cell_lineage 9 88 0.001055 0.04747
5 hsa04510_Focal_adhesion 14 200 0.002271 0.08175
6 hsa04912_GnRH_signaling_pathway 9 101 0.002766 0.08297
7 hsa04151_PI3K_AKT_signaling_pathway 20 351 0.003537 0.09096
8 hsa04722_Neurotrophin_signaling_pathway 10 127 0.004068 0.09154
9 hsa04020_Calcium_signaling_pathway 12 177 0.005843 0.1169
10 hsa04514_Cell_adhesion_molecules_.CAMs. 10 136 0.006566 0.1182
11 hsa04614_Renin.angiotensin_system 3 17 0.01235 0.1864
12 hsa04010_MAPK_signaling_pathway 15 268 0.01243 0.1864
13 hsa04012_ErbB_signaling_pathway 7 87 0.01354 0.1875
14 hsa04145_Phagosome 10 156 0.01625 0.209
15 hsa04370_VEGF_signaling_pathway 6 76 0.02343 0.2565
16 hsa00562_Inositol_phosphate_metabolism 5 57 0.02497 0.2565
17 hsa00240_Pyrimidine_metabolism 7 99 0.02571 0.2565
18 hsa04664_Fc_epsilon_RI_signaling_pathway 6 79 0.02772 0.2565
19 hsa04972_Pancreatic_secretion 7 101 0.02829 0.2565
20 hsa04621_NOD.like_receptor_signaling_pathway 5 59 0.0285 0.2565
21 hsa04310_Wnt_signaling_pathway 9 151 0.03305 0.2833
22 hsa04512_ECM.receptor_interaction 6 85 0.03779 0.303
23 hsa00280_Valine._leucine_and_isoleucine_degradation 4 44 0.03872 0.303
24 hsa04914_Progesterone.mediated_oocyte_maturation 6 87 0.0416 0.312
25 hsa04014_Ras_signaling_pathway 12 236 0.04454 0.3207
26 hsa04114_Oocyte_meiosis 7 114 0.04934 0.3379
27 hsa04610_Complement_and_coagulation_cascades 5 69 0.05069 0.3379
28 hsa04672_Intestinal_immune_network_for_IgA_production 4 49 0.05404 0.3474
29 hsa04971_Gastric_acid_secretion 5 74 0.06473 0.4018
30 hsa04070_Phosphatidylinositol_signaling_system 5 78 0.07738 0.4515
31 hsa00770_Pantothenate_and_CoA_biosynthesis 2 16 0.07776 0.4515
32 hsa00450_Selenocompound_metabolism 2 17 0.08648 0.4864
33 hsa04660_T_cell_receptor_signaling_pathway 6 108 0.09599 0.5135
34 hsa04810_Regulation_of_actin_cytoskeleton 10 214 0.09699 0.5135
35 hsa00230_Purine_metabolism 8 162 0.102 0.5151
36 hsa00100_Steroid_biosynthesis 2 19 0.1047 0.5151
37 hsa04910_Insulin_signaling_pathway 7 138 0.1092 0.5151
38 hsa00620_Pyruvate_metabolism 3 40 0.1104 0.5151
39 hsa04210_Apoptosis 5 89 0.1184 0.5197
40 hsa04970_Salivary_secretion 5 89 0.1184 0.5197
41 hsa04270_Vascular_smooth_muscle_contraction 6 116 0.1235 0.5293
42 hsa04670_Leukocyte_transendothelial_migration 6 117 0.1272 0.5324
43 hsa04962_Vasopressin.regulated_water_reabsorption 3 44 0.1363 0.5393
44 hsa04920_Adipocytokine_signaling_pathway 4 68 0.1366 0.5393
45 hsa04144_Endocytosis 9 203 0.1402 0.5393
46 hsa03050_Proteasome 3 45 0.143 0.5393
47 hsa00910_Nitrogen_metabolism 2 23 0.1438 0.5393
48 hsa04720_Long.term_potentiation 4 70 0.1473 0.5411
49 hsa04622_RIG.I.like_receptor_signaling_pathway 4 71 0.1527 0.5499
50 hsa04320_Dorso.ventral_axis_formation 2 25 0.1643 0.58
51 hsa00601_Glycosphingolipid_biosynthesis_._lacto_and_neolacto_series 2 26 0.1748 0.602
52 hsa04620_Toll.like_receptor_signaling_pathway 5 102 0.1773 0.602
53 hsa04062_Chemokine_signaling_pathway 8 189 0.188 0.6207
54 hsa00983_Drug_metabolism_._other_enzymes 3 52 0.1931 0.6207
55 hsa04742_Taste_transduction 3 52 0.1931 0.6207
56 hsa04650_Natural_killer_cell_mediated_cytotoxicity 6 136 0.2064 0.6517
57 hsa04974_Protein_digestion_and_absorption 4 81 0.2109 0.6546
58 hsa00020_Citrate_cycle_.TCA_cycle. 2 30 0.2174 0.6597
59 hsa04141_Protein_processing_in_endoplasmic_reticulum 7 168 0.2199 0.6597
60 hsa00250_Alanine._aspartate_and_glutamate_metabolism 2 32 0.2391 0.6725
61 hsa00260_Glycine._serine_and_threonine_metabolism 2 32 0.2391 0.6725
62 hsa00640_Propanoate_metabolism 2 32 0.2391 0.6725
63 hsa04140_Regulation_of_autophagy 2 34 0.2609 0.7224
64 hsa00565_Ether_lipid_metabolism 2 36 0.2827 0.7482
65 hsa00010_Glycolysis_._Gluconeogenesis 3 65 0.2944 0.7679
66 hsa04666_Fc_gamma_R.mediated_phagocytosis 4 95 0.3003 0.7722
67 hsa04730_Long.term_depression 3 70 0.3344 0.838
68 hsa00380_Tryptophan_metabolism 2 42 0.3474 0.838
69 hsa00071_Fatty_acid_metabolism 2 43 0.358 0.838
70 hsa04520_Adherens_junction 3 73 0.3585 0.838
71 hsa04662_B_cell_receptor_signaling_pathway 3 75 0.3744 0.864
72 hsa00514_Other_types_of_O.glycan_biosynthesis 2 46 0.3895 0.8874
73 hsa04330_Notch_signaling_pathway 2 47 0.3998 0.8885
74 hsa00510_N.Glycan_biosynthesis 2 49 0.4202 0.9005
75 hsa00480_Glutathione_metabolism 2 50 0.4303 0.9007
76 hsa00561_Glycerolipid_metabolism 2 50 0.4303 0.9007
77 hsa03015_mRNA_surveillance_pathway 3 83 0.4372 0.9045
78 hsa04150_mTOR_signaling_pathway 2 52 0.4502 0.9051
79 hsa04350_TGF.beta_signaling_pathway 3 85 0.4525 0.9051
80 hsa04390_Hippo_signaling_pathway 5 154 0.4675 0.9248
81 hsa04540_Gap_junction 3 90 0.4901 0.9258
82 hsa04360_Axon_guidance 4 130 0.5273 0.9631
83 hsa00970_Aminoacyl.tRNA_biosynthesis 2 63 0.5519 0.9631
84 hsa04916_Melanogenesis 3 101 0.5679 0.9631
85 hsa04120_Ubiquitin_mediated_proteolysis 4 139 0.5803 0.9631
86 hsa04115_p53_signaling_pathway 2 69 0.6015 0.9755
87 hsa04976_Bile_secretion 2 71 0.6171 0.9918
88 hsa00982_Drug_metabolism_._cytochrome_P450 2 73 0.6323 0.9985
89 hsa04260_Cardiac_muscle_contraction 2 77 0.6611 0.9985
90 hsa00564_Glycerophospholipid_metabolism 2 80 0.6815 1
91 hsa04142_Lysosome 3 121 0.6891 1
92 hsa04110_Cell_cycle 3 128 0.725 1
93 hsa03013_RNA_transport 3 152 0.8237 1

Quest ID: 02004dea38a993433088f2ac5d77ebef