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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-17-5p ABCD2 2.33 0.30125 -2.73 0.01225 MirTarget -0.54 0 NA
2 hsa-miR-17-5p ABHD2 2.33 0.30125 0.09 0.9591 TargetScan; miRNATAP -0.18 0.00209 NA
3 hsa-miR-454-3p ACSL1 1.37 0.14233 -0.18 0.89649 MirTarget -0.21 0.00407 NA
4 hsa-miR-454-3p ACSL4 1.37 0.14233 -0.96 0.51944 MirTarget; miRNATAP -0.14 0.04315 NA
5 hsa-miR-454-3p ACVR1 1.37 0.14233 -0.76 0.54869 MirTarget; miRNATAP -0.12 0.00599 NA
6 hsa-miR-17-5p ACVRL1 2.33 0.30125 -3.43 0.00079 TargetScan -0.23 0.0002 NA
7 hsa-miR-17-5p ADAMTS5 2.33 0.30125 -6.31 0 TargetScan -0.22 0.02546 NA
8 hsa-miR-17-5p AFF1 2.33 0.30125 -1.07 0.49725 TargetScan -0.11 0.00674 NA
9 hsa-miR-17-5p AGFG2 2.33 0.30125 -1.28 0.29482 TargetScan; miRNATAP -0.19 1.0E-5 NA
10 hsa-miR-17-5p AHNAK 2.33 0.30125 -1.04 0.64703 TargetScan; miRNATAP -0.18 0.00111 NA
11 hsa-miR-454-3p AKAP11 1.37 0.14233 -0.66 0.63974 miRNATAP -0.12 0.00898 NA
12 hsa-miR-17-5p AKAP13 2.33 0.30125 -1.53 0.37244 MirTarget; TargetScan; mirMAP; miRNATAP -0.19 0 NA
13 hsa-miR-17-5p AKT3 2.33 0.30125 -3.26 0.00117 TargetScan; miRNATAP -0.17 0.02914 NA
14 hsa-miR-454-3p AMPD3 1.37 0.14233 1.49 0.13818 MirTarget; miRNATAP -0.28 3.0E-5 NA
15 hsa-miR-17-5p ANK2 2.33 0.30125 -5.43 0 MirTarget; miRNATAP -0.6 0 NA
16 hsa-miR-454-3p ANKRD12 1.37 0.14233 -0.46 0.71724 MirTarget; miRNATAP -0.11 0.01667 NA
17 hsa-miR-17-5p ANKRD29 2.33 0.30125 -2.22 0.05518 MirTarget; TargetScan -0.54 0 NA
18 hsa-miR-17-5p ANKRD50 2.33 0.30125 0 0.99734 MirTarget; TargetScan; miRNATAP -0.16 0.00363 NA
19 hsa-miR-17-5p ANXA11 2.33 0.30125 -0.04 0.98232 mirMAP -0.11 0.00676 NA
20 hsa-miR-17-5p AR 2.33 0.30125 -4.67 0.00218 mirMAP -0.79 0 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells
21 hsa-miR-454-3p AR 1.37 0.14233 -4.67 0.00218 mirMAP; miRNATAP -0.47 0.00625 NA
22 hsa-miR-17-5p ARAP2 2.33 0.30125 1.85 0.12177 MirTarget; TargetScan -0.14 0.01554 NA
23 hsa-miR-454-3p ARAP2 1.37 0.14233 1.85 0.12177 MirTarget -0.2 0.00207 NA
24 hsa-miR-454-3p ARHGAP21 1.37 0.14233 -0.06 0.96644 MirTarget; miRNATAP -0.14 0.01042 NA
25 hsa-miR-17-5p ARHGAP24 2.33 0.30125 -1.57 0.12603 MirTarget -0.23 0.01058 NA
26 hsa-miR-17-5p ARHGAP26 2.33 0.30125 -0.19 0.90211 MirTarget; TargetScan; mirMAP; miRNATAP -0.23 0.00209 NA
27 hsa-miR-17-5p ARHGAP31 2.33 0.30125 -2.29 0.00905 TargetScan -0.3 0 NA
28 hsa-miR-454-3p ARHGEF12 1.37 0.14233 -0.46 0.79305 MirTarget; miRNATAP -0.16 0.0003 NA
29 hsa-miR-17-5p ARHGEF3 2.33 0.30125 -1.01 0.44523 MirTarget; TargetScan; miRNATAP -0.16 0.00015 NA
30 hsa-miR-17-5p ARL4C 2.33 0.30125 1.91 0.17875 MirTarget; TargetScan; miRNATAP -0.15 0.03095 NA
31 hsa-miR-17-5p ARSD 2.33 0.30125 0 0.99908 mirMAP -0.32 0 NA
32 hsa-miR-17-5p ASPA 2.33 0.30125 -5.59 0.00012 mirMAP -0.55 1.0E-5 NA
33 hsa-miR-454-3p ASPA 1.37 0.14233 -5.59 0.00012 mirMAP -0.32 0.02559 NA
34 hsa-miR-454-3p ASXL2 1.37 0.14233 0.94 0.44816 MirTarget; miRNATAP -0.2 0.03105 NA
35 hsa-miR-17-5p ASXL3 2.33 0.30125 -4.32 0.00164 TargetScan -0.39 0.00638 NA
36 hsa-miR-17-5p ATF3 2.33 0.30125 -0.68 0.67723 miRNAWalker2 validate -0.18 0.03451 NA
37 hsa-miR-17-5p ATOH8 2.33 0.30125 -5.62 0 TargetScan -0.36 0.00027 NA
38 hsa-miR-17-5p ATP1A2 2.33 0.30125 -7.07 0 MirTarget; TargetScan -0.72 0 NA
39 hsa-miR-454-3p ATP6V1B2 1.37 0.14233 0.31 0.84053 MirTarget; miRNATAP -0.1 0.00585 NA
40 hsa-miR-17-5p ATXN1 2.33 0.30125 -1.44 0.25265 TargetScan; miRNATAP -0.19 0.00016 NA
41 hsa-miR-454-3p ATXN1 1.37 0.14233 -1.44 0.25265 miRNATAP -0.17 0.00303 NA
42 hsa-miR-17-5p ATXN7L1 2.33 0.30125 -0.26 0.74464 TargetScan -0.18 0 NA
43 hsa-miR-454-3p BBX 1.37 0.14233 -0.17 0.90638 MirTarget; miRNATAP -0.1 0.02182 NA
44 hsa-miR-17-5p BCAS1 2.33 0.30125 -0.49 0.78808 mirMAP -0.86 0 NA
45 hsa-miR-17-5p BCL6 2.33 0.30125 -0.43 0.75836 TargetScan -0.16 0.0008 NA
46 hsa-miR-454-3p BCL9L 1.37 0.14233 -0.07 0.96468 mirMAP -0.14 0.00577 NA
47 hsa-miR-454-3p BHLHE40 1.37 0.14233 1.11 0.56907 miRNAWalker2 validate -0.24 0.00086 NA
48 hsa-miR-17-5p BHLHE41 2.33 0.30125 -1.42 0.31661 TargetScan; miRNATAP -0.44 1.0E-5 NA
49 hsa-miR-17-5p BICC1 2.33 0.30125 -2.29 0.08377 TargetScan -0.31 0.02277 NA
50 hsa-miR-17-5p BMPR2 2.33 0.30125 -1.14 0.45199 miRNAWalker2 validate; MirTarget; TargetScan; miRNATAP -0.12 0.00049 NA
51 hsa-miR-17-5p BNC2 2.33 0.30125 -6.05 0 TargetScan; miRNATAP -0.58 0 NA
52 hsa-miR-454-3p BRWD3 1.37 0.14233 2.17 0.04658 MirTarget; miRNATAP -0.2 0.01287 NA
53 hsa-miR-454-3p BTBD10 1.37 0.14233 0.53 0.66167 MirTarget -0.18 3.0E-5 NA
54 hsa-miR-17-5p BTG1 2.33 0.30125 -0.79 0.64588 TargetScan -0.12 0.00371 NA
55 hsa-miR-454-3p BTG1 1.37 0.14233 -0.79 0.64588 miRNATAP -0.11 0.02771 NA
56 hsa-miR-17-5p BTG2 2.33 0.30125 -1.97 0.25098 TargetScan -0.11 0.04449 NA
57 hsa-miR-17-5p BTN3A1 2.33 0.30125 -0.3 0.82105 miRNAWalker2 validate -0.24 0.00014 NA
58 hsa-miR-409-3p BTN3A2 0.28 0.79947 -0.05 0.97293 mirMAP -0.13 0.01301 NA
59 hsa-miR-17-5p C14orf28 2.33 0.30125 -2.37 0.00011 TargetScan; miRNATAP -0.23 0 NA
60 hsa-miR-454-3p C15orf52 1.37 0.14233 -1.25 0.3319 mirMAP -0.36 0.00077 NA
61 hsa-miR-454-3p C1S 1.37 0.14233 -1.82 0.27315 MirTarget -0.25 0.01612 NA
62 hsa-miR-409-3p C1orf21 0.28 0.79947 -1.12 0.41646 PITA; mirMAP -0.13 0.02071 NA
63 hsa-miR-17-5p C3orf70 2.33 0.30125 -3.26 0.00156 TargetScan -0.21 0.04273 NA
64 hsa-miR-17-5p CA10 2.33 0.30125 -3.64 0.02709 miRNATAP -0.33 0.02235 NA
65 hsa-miR-17-5p CALD1 2.33 0.30125 -3.71 0.02146 TargetScan; miRNATAP -0.21 0.00428 NA
66 hsa-miR-17-5p CAPN5 2.33 0.30125 -1.94 0.26998 mirMAP -0.37 0.00205 NA
67 hsa-miR-17-5p CASC4 2.33 0.30125 -1.45 0.37749 MirTarget -0.14 0.0007 NA
68 hsa-miR-17-5p CBX7 2.33 0.30125 -3.22 0.00976 mirMAP -0.32 0 NA
69 hsa-miR-454-3p CD109 1.37 0.14233 0.41 0.73596 mirMAP -0.3 0.02391 NA
70 hsa-miR-17-5p CD226 2.33 0.30125 0.6 0.47807 TargetScan -0.32 6.0E-5 NA
71 hsa-miR-17-5p CD69 2.33 0.30125 -0.62 0.5233 TargetScan; miRNATAP -0.44 0 NA
72 hsa-miR-454-3p CD69 1.37 0.14233 -0.62 0.5233 miRNATAP -0.25 0.01834 NA
73 hsa-miR-454-3p CDH11 1.37 0.14233 -2.75 0.04281 mirMAP -0.48 7.0E-5 NA
74 hsa-miR-17-5p CELF2 2.33 0.30125 -2.38 0.01903 TargetScan -0.3 0.00014 NA
75 hsa-miR-17-5p CHD9 2.33 0.30125 -0.24 0.84856 MirTarget; TargetScan; miRNATAP -0.17 7.0E-5 NA
76 hsa-miR-454-3p CHD9 1.37 0.14233 -0.24 0.84856 miRNATAP -0.17 0.00054 NA
77 hsa-miR-17-5p CHIC1 2.33 0.30125 -1.78 0.08872 TargetScan -0.26 5.0E-5 NA
78 hsa-miR-17-5p CIITA 2.33 0.30125 0.67 0.63916 mirMAP -0.21 0.04302 NA
79 hsa-miR-17-5p CLIC6 2.33 0.30125 -0.19 0.92919 mirMAP -0.47 0.00962 NA
80 hsa-miR-454-3p CLIP1 1.37 0.14233 0.42 0.78033 MirTarget; miRNATAP -0.21 7.0E-5 NA
81 hsa-miR-409-3p CLYBL 0.28 0.79947 -0.96 0.26882 miRNATAP -0.14 0.0173 NA
82 hsa-miR-17-5p CMKLR1 2.33 0.30125 -2.3 0.0139 TargetScan -0.35 9.0E-5 NA
83 hsa-miR-17-5p CNN1 2.33 0.30125 -8.99 0 TargetScan -0.71 0 NA
84 hsa-miR-17-5p COL1A1 2.33 0.30125 -1.82 0.45918 mirMAP -0.33 0.00039 NA
85 hsa-miR-17-5p COL8A2 2.33 0.30125 -0.42 0.72104 mirMAP -0.23 0.01147 NA
86 hsa-miR-17-5p CORO2B 2.33 0.30125 -3.77 0.00099 MirTarget; TargetScan; miRNATAP -0.33 0.00536 NA
87 hsa-miR-454-3p CPEB2 1.37 0.14233 -0.45 0.66859 miRNATAP -0.16 0.01428 NA
88 hsa-miR-17-5p CPEB3 2.33 0.30125 -0.09 0.91502 TargetScan; miRNATAP -0.21 5.0E-5 NA
89 hsa-miR-17-5p CPEB4 2.33 0.30125 -0.68 0.57172 mirMAP -0.18 0.00148 NA
90 hsa-miR-454-3p CPEB4 1.37 0.14233 -0.68 0.57172 miRNATAP -0.16 0.01341 NA
91 hsa-miR-17-5p CREB3L2 2.33 0.30125 -2.18 0.1571 mirMAP -0.14 0.02334 NA
92 hsa-miR-454-3p CRISPLD1 1.37 0.14233 -3.16 0.0237 MirTarget -0.4 0.01665 NA
93 hsa-miR-17-5p CROT 2.33 0.30125 0.76 0.43857 MirTarget -0.29 0 NA
94 hsa-miR-17-5p CRY2 2.33 0.30125 -2.56 0.03317 MirTarget; TargetScan; miRNATAP -0.14 6.0E-5 NA
95 hsa-miR-17-5p CRYBG3 2.33 0.30125 -0.03 0.98149 MirTarget; TargetScan; miRNATAP -0.24 0.00055 NA
96 hsa-miR-17-5p CSF1 2.33 0.30125 -0.95 0.36961 TargetScan; miRNATAP -0.15 0.04971 NA
97 hsa-miR-454-3p CSF1 1.37 0.14233 -0.95 0.36961 MirTarget; miRNATAP -0.2 0.02018 NA
98 hsa-miR-17-5p CTSK 2.33 0.30125 -3.24 0.01457 MirTarget -0.57 0 NA
99 hsa-miR-454-3p CTSK 1.37 0.14233 -3.24 0.01457 MirTarget -0.47 0 NA
100 hsa-miR-17-5p CXCL14 2.33 0.30125 2.15 0.29887 TargetScan -0.63 0.00031 NA
101 hsa-miR-17-5p CXorf23 2.33 0.30125 -0.34 0.66995 mirMAP -0.11 0.00156 NA
102 hsa-miR-17-5p CXorf36 2.33 0.30125 -4.78 0 mirMAP -0.35 0 NA
103 hsa-miR-17-5p CYBRD1 2.33 0.30125 -3.37 0.0305 MirTarget; TargetScan -0.16 0.02987 NA
104 hsa-miR-454-3p CYLD 1.37 0.14233 0.07 0.95683 miRNATAP -0.12 0.0045 25824771 MiR 454 prompts cell proliferation of human colorectal cancer cells by repressing CYLD expression; Bioinformatics analysis further revealed cylindromatosis CYLD a putative tumor suppressor as a potential target of miR-454; Data from luciferase reporter assays showed that miR-454 directly binds to the 3'-untranslated region 3'-UTR of CYLD mRNA and repressed expression at both transcriptional and translational levels; In sum our data provide compelling evidence that miR-454 functions as an onco-miRNA playing a crucial role in the promoting cell proliferation in CRC and its oncogenic effect is mediated chiefly through direct suppression of CYLD expression
105 hsa-miR-17-5p CYP2U1 2.33 0.30125 -2.36 0.00403 MirTarget; TargetScan -0.18 0.00404 NA
106 hsa-miR-454-3p CYP4F3 1.37 0.14233 5.51 0.00095 mirMAP -0.39 0.04343 NA
107 hsa-miR-454-3p DAAM1 1.37 0.14233 0.41 0.70774 MirTarget; miRNATAP -0.24 0.00186 NA
108 hsa-miR-17-5p DAB2 2.33 0.30125 -2.26 0.05568 MirTarget; TargetScan; miRNATAP -0.27 7.0E-5 NA
109 hsa-miR-17-5p DIP2C 2.33 0.30125 -1.77 0.13518 TargetScan -0.13 0.00918 NA
110 hsa-miR-17-5p DIXDC1 2.33 0.30125 -4.41 1.0E-5 mirMAP -0.16 0.02341 NA
111 hsa-miR-454-3p DLC1 1.37 0.14233 -3.78 0.00054 miRNATAP -0.3 0.00062 NA
112 hsa-miR-17-5p DLG2 2.33 0.30125 -5.01 0.00037 mirMAP -0.55 8.0E-5 NA
113 hsa-miR-17-5p DNAJB9 2.33 0.30125 -1.01 0.40421 TargetScan; miRNATAP -0.14 0.00022 NA
114 hsa-miR-17-5p DNAJC27 2.33 0.30125 -1.45 0.03033 miRNAWalker2 validate; miRTarBase; MirTarget; TargetScan; miRNATAP -0.12 0.00024 NA
115 hsa-miR-454-3p DNM3 1.37 0.14233 -2.67 0.00065 mirMAP -0.27 0.00193 NA
116 hsa-miR-17-5p DNMBP 2.33 0.30125 -0.36 0.79984 miRNAWalker2 validate -0.12 0.01184 NA
117 hsa-miR-17-5p DOK6 2.33 0.30125 -3.39 0.00047 TargetScan -0.42 0 NA
118 hsa-miR-17-5p DPYD 2.33 0.30125 -0.1 0.93539 MirTarget -0.29 0.00043 NA
119 hsa-miR-17-5p DYRK2 2.33 0.30125 -0.04 0.97485 TargetScan -0.11 0.0068 NA
120 hsa-miR-454-3p DYRK2 1.37 0.14233 -0.04 0.97485 mirMAP -0.11 0.02274 NA
121 hsa-miR-17-5p EDA2R 2.33 0.30125 -4.24 0.00028 MirTarget; TargetScan -0.38 0.00065 NA
122 hsa-miR-17-5p EEA1 2.33 0.30125 -0.13 0.91328 MirTarget; TargetScan; miRNATAP -0.15 0.00185 NA
123 hsa-miR-454-3p EEA1 1.37 0.14233 -0.13 0.91328 mirMAP -0.23 2.0E-5 NA
124 hsa-miR-17-5p EGR2 2.33 0.30125 -1.31 0.18551 MirTarget; TargetScan; miRNATAP -0.17 0.04204 27725906 Early Growth Response 2 EGR2 protein or mRNA levels were downregulated or upregulated after overexpression or knockdown of miR-17-5p respectively; By using dual luciferase assay and Western blot we identified EGR2 as a functional target of miR-17-5p
125 hsa-miR-17-5p ELK3 2.33 0.30125 -0.61 0.55433 MirTarget; TargetScan; miRNATAP -0.22 0.00476 NA
126 hsa-miR-454-3p ELK3 1.37 0.14233 -0.61 0.55433 MirTarget; miRNATAP -0.42 0 NA
127 hsa-miR-409-3p EMP2 0.28 0.79947 0.97 0.61201 mirMAP -0.11 0.01499 NA
128 hsa-miR-454-3p ENAH 1.37 0.14233 -0.2 0.90546 miRNATAP -0.13 0.03879 NA
129 hsa-miR-454-3p ENDOD1 1.37 0.14233 -1.1 0.42656 MirTarget -0.23 4.0E-5 NA
130 hsa-miR-17-5p ENPP1 2.33 0.30125 -5.64 1.0E-5 mirMAP -0.33 0.00664 NA
131 hsa-miR-17-5p ENTPD1 2.33 0.30125 -1.63 0.20648 mirMAP -0.14 4.0E-5 NA
132 hsa-miR-17-5p EPHA4 2.33 0.30125 -1 0.38187 TargetScan; miRNATAP -0.22 0.0435 NA
133 hsa-miR-17-5p EPM2AIP1 2.33 0.30125 -1.07 0.40187 mirMAP -0.12 0.01401 NA
134 hsa-miR-17-5p ESR1 2.33 0.30125 -5.06 0.0022 TargetScan -0.71 0 NA
135 hsa-miR-454-3p ESR1 1.37 0.14233 -5.06 0.0022 miRNATAP -0.52 0.00045 NA
136 hsa-miR-17-5p ETV1 2.33 0.30125 -1.67 0.14511 MirTarget; TargetScan; miRNATAP -0.47 0 26158900 miR 17 regulates melanoma cell motility by inhibiting the translation of ETV1; TargetScan algorithm predicts the PEA3-subfamily member ETV1 as a direct target of miR-17; Indeed a 3-4-fold decrease of ETV1 protein levels are observed following miR-17 transfection into the various melanoma lines with no significant change in ETV1 mRNA expression; Dual luciferase experiments demonstrate direct binding of miR-17 to the 3'-untranslated region of ETV1 confirmed by abolishing point mutations in the putative binding site; These combined results suggest regulation of ETV1 by miR-17 by a direct translational repression; In conclusion we show a new role for miR-17 in melanoma facilitating cell motility by targeting the translation of ETV1 protein which may support the development of metastasis
137 hsa-miR-454-3p EVI5 1.37 0.14233 -1.03 0.33581 mirMAP -0.1 0.00889 NA
138 hsa-miR-17-5p EZH1 2.33 0.30125 -1.83 0.14012 MirTarget; TargetScan; miRNATAP -0.11 0.00026 27633093 The luciferase assay of 3'-untranslated region UTR demonstrates that EZH1 is a direct target of miR-17-5p and EZH1 RNAi recapitulates the effect of miR-17-5p overexpression on erlotinib resistance; Our results indicate that miR-17-5p down-regulation contributes to erlotinib resistance of NSCLC by modulating its target genes such as EZH1 and plasma miR-17-5p might be a potential biomarker of erlotinib response in NSCLC patients
139 hsa-miR-17-5p FAIM2 2.33 0.30125 -4.54 0.00017 TargetScan -0.55 2.0E-5 NA
140 hsa-miR-17-5p FAM102A 2.33 0.30125 -0.05 0.97337 TargetScan; miRNATAP -0.21 1.0E-5 NA
141 hsa-miR-17-5p FAM129A 2.33 0.30125 -0.94 0.49779 TargetScan -0.41 0 26317551 The expression of two selected microRNAs miR-17-5p miR-106b and the expression of C1orf24 were tested in 48 benign and malignant thyroid lesions and in five thyroid carcinoma cell lines
142 hsa-miR-17-5p FAM131B 2.33 0.30125 -2.46 0.00246 TargetScan -0.38 0 NA
143 hsa-miR-17-5p FAM13A 2.33 0.30125 -1.61 0.23732 TargetScan -0.14 0.0459 NA
144 hsa-miR-454-3p FAM155A 1.37 0.14233 -3.26 0.00375 MirTarget -0.36 0.00573 NA
145 hsa-miR-17-5p FAM160B2 2.33 0.30125 0.09 0.95062 TargetScan -0.1 0.00481 NA
146 hsa-miR-454-3p FAM179B 1.37 0.14233 -0.55 0.56378 miRNATAP -0.12 0.0124 NA
147 hsa-miR-17-5p FAM189A1 2.33 0.30125 -1.97 0.19359 MirTarget; TargetScan; miRNATAP -0.34 0.03934 NA
148 hsa-miR-17-5p FAM3C 2.33 0.30125 -0.71 0.64888 TargetScan -0.14 0.00193 NA
149 hsa-miR-454-3p FAM46B 1.37 0.14233 0.7 0.57694 MirTarget; miRNATAP -0.29 0.01569 NA
150 hsa-miR-17-5p FAM46C 2.33 0.30125 -0.89 0.48739 MirTarget; TargetScan; miRNATAP -0.23 0.00674 NA
NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 96 1518 2.57e-15 1.196e-11
2 REGULATION OF CELL DIFFERENTIATION 93 1492 1.837e-14 4.275e-11
3 CARDIOVASCULAR SYSTEM DEVELOPMENT 62 788 3.751e-14 4.364e-11
4 CIRCULATORY SYSTEM DEVELOPMENT 62 788 3.751e-14 4.364e-11
5 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 102 1805 4.007e-13 3.729e-10
6 POSITIVE REGULATION OF GENE EXPRESSION 98 1733 1.237e-12 9.59e-10
7 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 94 1656 3.181e-12 2.115e-09
8 ORGAN MORPHOGENESIS 60 841 6.472e-12 3.764e-09
9 MUSCLE TISSUE DEVELOPMENT 31 275 1.933e-11 9.994e-09
10 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 31 278 2.56e-11 1.191e-08
11 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 96 1784 3.685e-11 1.559e-08
12 TISSUE MORPHOGENESIS 44 533 5.108e-11 1.981e-08
13 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 91 1672 7.312e-11 2.617e-08
14 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 23 162 7.922e-11 2.633e-08
15 POSITIVE REGULATION OF MOLECULAR FUNCTION 95 1791 1.045e-10 3.241e-08
16 POSITIVE REGULATION OF CELL COMMUNICATION 85 1532 1.341e-10 3.325e-08
17 EMBRYONIC ORGAN MORPHOGENESIS 30 279 1.33e-10 3.325e-08
18 HEART DEVELOPMENT 40 466 1.246e-10 3.325e-08
19 NEUROGENESIS 80 1402 1.358e-10 3.325e-08
20 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 24 184 1.862e-10 4.333e-08
21 SKELETAL SYSTEM DEVELOPMENT 39 455 2.234e-10 4.95e-08
22 POSITIVE REGULATION OF RESPONSE TO STIMULUS 99 1929 2.42e-10 5.109e-08
23 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 96 1848 2.525e-10 5.109e-08
24 CELL DEVELOPMENT 80 1426 3.05e-10 5.913e-08
25 POSITIVE REGULATION OF CATALYTIC ACTIVITY 83 1518 4.673e-10 8.363e-08
26 REGULATION OF CELLULAR COMPONENT MOVEMENT 53 771 4.624e-10 8.363e-08
27 VASCULATURE DEVELOPMENT 39 469 5.399e-10 9.304e-08
28 EMBRYO DEVELOPMENT 58 894 6.025e-10 9.667e-08
29 POSITIVE REGULATION OF CELL DIFFERENTIATION 55 823 5.968e-10 9.667e-08
30 EMBRYONIC MORPHOGENESIS 42 539 8.373e-10 1.299e-07
31 TUBE MORPHOGENESIS 31 323 1.111e-09 1.668e-07
32 EMBRYONIC ORGAN DEVELOPMENT 35 406 1.659e-09 2.412e-07
33 TUBE DEVELOPMENT 42 552 1.711e-09 2.413e-07
34 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 62 1021 1.983e-09 2.714e-07
35 MUSCLE STRUCTURE DEVELOPMENT 36 432 2.401e-09 3.192e-07
36 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 61 1004 2.657e-09 3.435e-07
37 REGULATION OF GTPASE ACTIVITY 47 673 2.875e-09 3.616e-07
38 REGULATION OF SYSTEM PROCESS 39 507 4.923e-09 5.873e-07
39 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 52 801 4.877e-09 5.873e-07
40 POSITIVE REGULATION OF CELL DEVELOPMENT 37 472 7.481e-09 8.702e-07
41 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 60 1008 7.762e-09 8.809e-07
42 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 65 1142 1e-08 1.108e-06
43 CENTRAL NERVOUS SYSTEM DEVELOPMENT 54 872 1.231e-08 1.332e-06
44 POSITIVE REGULATION OF LOCOMOTION 34 420 1.394e-08 1.474e-06
45 MORPHOGENESIS OF AN EPITHELIUM 33 400 1.444e-08 1.493e-06
46 RESPONSE TO ENDOGENOUS STIMULUS 76 1450 1.754e-08 1.775e-06
47 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 57 957 1.859e-08 1.84e-06
48 BLOOD VESSEL MORPHOGENESIS 31 364 1.915e-08 1.856e-06
49 REGULATION OF CELL DEVELOPMENT 52 836 2.022e-08 1.92e-06
50 EPITHELIUM DEVELOPMENT 56 945 2.978e-08 2.771e-06
51 NEGATIVE REGULATION OF GENE EXPRESSION 76 1493 5.923e-08 5.404e-06
52 NEURON DIFFERENTIATION 52 874 8.476e-08 7.441e-06
53 NEGATIVE REGULATION OF CELL DIFFERENTIATION 41 609 8.415e-08 7.441e-06
54 REGULATION OF PHOSPHORUS METABOLIC PROCESS 80 1618 8.695e-08 7.492e-06
55 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 52 876 9.112e-08 7.709e-06
56 BIOLOGICAL ADHESION 58 1032 1.035e-07 8.601e-06
57 REGULATION OF PROTEIN MODIFICATION PROCESS 83 1710 1.063e-07 8.674e-06
58 REGULATION OF HYDROLASE ACTIVITY 69 1327 1.179e-07 9.457e-06
59 NEGATIVE REGULATION OF CELL PROLIFERATION 42 643 1.337e-07 1.055e-05
60 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 70 1360 1.392e-07 1.08e-05
61 POSITIVE REGULATION OF CELL DEATH 40 605 1.958e-07 1.494e-05
62 INTRACELLULAR SIGNAL TRANSDUCTION 77 1572 2.299e-07 1.726e-05
63 POSITIVE REGULATION OF HYDROLASE ACTIVITY 52 905 2.523e-07 1.863e-05
64 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 55 983 2.621e-07 1.905e-05
65 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 70 1395 3.618e-07 2.551e-05
66 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 45 740 3.601e-07 2.551e-05
67 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 27 337 5.38e-07 3.737e-05
68 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 35 513 5.594e-07 3.828e-05
69 SENSORY ORGAN DEVELOPMENT 34 493 6.368e-07 4.295e-05
70 REGULATION OF MAPK CASCADE 41 660 7.047e-07 4.684e-05
71 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 42 689 8.421e-07 5.519e-05
72 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 20 207 9.196e-07 5.943e-05
73 POSITIVE REGULATION OF NEURON DIFFERENTIATION 25 306 9.905e-07 6.314e-05
74 BONE DEVELOPMENT 17 156 1.144e-06 7.194e-05
75 NEGATIVE REGULATION OF CELL COMMUNICATION 61 1192 1.166e-06 7.234e-05
76 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 36 554 1.216e-06 7.442e-05
77 CARDIAC MUSCLE TISSUE DEVELOPMENT 16 140 1.248e-06 7.542e-05
78 LOCOMOTION 58 1114 1.271e-06 7.581e-05
79 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 55 1036 1.354e-06 7.874e-05
80 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 55 1036 1.354e-06 7.874e-05
81 REGULATION OF CELL ADHESION 39 629 1.389e-06 7.978e-05
82 REGULATION OF MUSCLE SYSTEM PROCESS 19 195 1.513e-06 8.585e-05
83 CELL CELL ADHESION 38 608 1.572e-06 8.706e-05
84 ANGIOGENESIS 24 293 1.556e-06 8.706e-05
85 REGULATION OF OSSIFICATION 18 178 1.667e-06 9.124e-05
86 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 72 1517 1.9e-06 0.0001028
87 EAR MORPHOGENESIS 14 112 1.965e-06 0.0001039
88 REGULATION OF CHEMOTAXIS 18 180 1.959e-06 0.0001039
89 RHYTHMIC PROCESS 24 298 2.096e-06 0.0001096
90 NEURON PROJECTION DEVELOPMENT 35 545 2.234e-06 0.0001142
91 POSITIVE REGULATION OF AXONOGENESIS 11 69 2.221e-06 0.0001142
92 SKELETAL SYSTEM MORPHOGENESIS 19 201 2.382e-06 0.0001205
93 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 63 1275 2.462e-06 0.0001232
94 REGULATION OF CELL MORPHOGENESIS 35 552 2.971e-06 0.0001471
95 REGULATION OF NEURON DIFFERENTIATION 35 554 3.22e-06 0.0001577
96 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 15 135 3.81e-06 0.0001847
97 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 16 153 4.049e-06 0.0001942
98 HEAD DEVELOPMENT 41 709 4.239e-06 0.0001993
99 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 18 190 4.24e-06 0.0001993
100 RESPONSE TO MECHANICAL STIMULUS 19 210 4.549e-06 0.0002096
101 DEVELOPMENTAL GROWTH 25 333 4.532e-06 0.0002096
102 NEURON DEVELOPMENT 40 687 4.728e-06 0.0002134
103 REGULATION OF CELL SUBSTRATE ADHESION 17 173 4.771e-06 0.0002134
104 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 57 1135 4.759e-06 0.0002134
105 POSITIVE REGULATION OF MAPK CASCADE 31 470 4.986e-06 0.0002209
106 NEURON PROJECTION MORPHOGENESIS 28 402 5.186e-06 0.0002276
107 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 44 799 6.557e-06 0.0002851
108 REGULATION OF JNK CASCADE 16 159 6.666e-06 0.0002872
109 INNER EAR MORPHOGENESIS 12 92 6.766e-06 0.0002888
110 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 18 197 7.044e-06 0.0002979
111 MUSCLE CELL DIFFERENTIATION 20 237 7.372e-06 0.000309
112 REGULATION OF RHO PROTEIN SIGNAL TRANSDUCTION 13 109 7.698e-06 0.0003198
113 POSITIVE REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 8 39 7.888e-06 0.0003248
114 REGULATION OF CELL PROLIFERATION 69 1496 8.409e-06 0.0003432
115 MESODERM MORPHOGENESIS 10 66 1.028e-05 0.0004159
116 CARTILAGE DEVELOPMENT 15 147 1.088e-05 0.0004364
117 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 18 204 1.141e-05 0.000454
118 CELLULAR COMPONENT MORPHOGENESIS 47 900 1.266e-05 0.0004994
119 ACTIN FILAMENT BASED PROCESS 29 450 1.555e-05 0.0006081
120 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 19 229 1.578e-05 0.000612
121 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 41 750 1.618e-05 0.0006122
122 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 40 724 1.615e-05 0.0006122
123 RESPONSE TO OXYGEN CONTAINING COMPOUND 64 1381 1.592e-05 0.0006122
124 MESENCHYME DEVELOPMENT 17 190 1.659e-05 0.0006226
125 REGULATION OF CELL DEATH 67 1472 1.76e-05 0.0006551
126 MESODERM DEVELOPMENT 13 118 1.837e-05 0.0006782
127 CELL MOTILITY 44 835 1.945e-05 0.0007014
128 HEART MORPHOGENESIS 18 212 1.927e-05 0.0007014
129 LOCALIZATION OF CELL 44 835 1.945e-05 0.0007014
130 GROWTH 27 410 2.084e-05 0.000746
131 CELL DEATH 50 1001 2.172e-05 0.0007684
132 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 12 103 2.18e-05 0.0007684
133 TISSUE REMODELING 11 87 2.202e-05 0.0007703
134 CIRCULATORY SYSTEM PROCESS 25 366 2.292e-05 0.0007909
135 UROGENITAL SYSTEM DEVELOPMENT 22 299 2.295e-05 0.0007909
136 EAR DEVELOPMENT 17 195 2.324e-05 0.0007953
137 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 28 437 2.414e-05 0.0008197
138 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 25 368 2.509e-05 0.0008461
139 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 13 122 2.629e-05 0.00088
140 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 7 34 2.873e-05 0.000926
141 CARDIAC MUSCLE CELL DIFFERENTIATION 10 74 2.886e-05 0.000926
142 MULTICELLULAR ORGANISMAL SIGNALING 13 123 2.869e-05 0.000926
143 SENSORY ORGAN MORPHOGENESIS 19 239 2.865e-05 0.000926
144 EMBRYONIC CRANIAL SKELETON MORPHOGENESIS 8 46 2.834e-05 0.000926
145 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 22 303 2.811e-05 0.000926
146 REGULATION OF FAT CELL DIFFERENTIATION 12 106 2.916e-05 0.0009293
147 REGULATION OF SMOOTH MUSCLE CONTRACTION 9 60 3.096e-05 0.0009799
148 OLFACTORY BULB INTERNEURON DIFFERENTIATION 5 15 3.38e-05 0.001063
149 FORMATION OF PRIMARY GERM LAYER 12 110 4.227e-05 0.00132
150 OLFACTORY LOBE DEVELOPMENT 7 36 4.254e-05 0.00132
151 CELL JUNCTION ORGANIZATION 16 185 4.425e-05 0.001364
152 REGULATION OF EPITHELIAL CELL MIGRATION 15 166 4.6e-05 0.001391
153 REGULATION OF MUSCLE CONTRACTION 14 147 4.604e-05 0.001391
154 RESPONSE TO HORMONE 45 893 4.605e-05 0.001391
155 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 66 1492 4.907e-05 0.001473
156 TELENCEPHALON DEVELOPMENT 18 228 5.062e-05 0.00151
157 CARDIOCYTE DIFFERENTIATION 11 96 5.574e-05 0.001652
158 REGULATION OF CELL PROJECTION ORGANIZATION 32 558 5.684e-05 0.001674
159 RESPONSE TO CYTOKINE 38 714 5.868e-05 0.001717
160 REGULATION OF MAP KINASE ACTIVITY 22 319 6.089e-05 0.001763
161 STEM CELL DIFFERENTIATION 16 190 6.102e-05 0.001763
162 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 18 232 6.346e-05 0.001823
163 REGULATION OF MUSCLE CELL DIFFERENTIATION 14 152 6.647e-05 0.001897
164 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 14 153 7.139e-05 0.002025
165 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 11 99 7.408e-05 0.002064
166 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 11 99 7.408e-05 0.002064
167 DEVELOPMENTAL MATURATION 16 193 7.356e-05 0.002064
168 CONNECTIVE TISSUE DEVELOPMENT 16 194 7.822e-05 0.002166
169 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 8 53 8.157e-05 0.002246
170 PROTEIN PHOSPHORYLATION 46 944 8.415e-05 0.002303
171 ORGAN GROWTH 9 68 8.524e-05 0.00232
172 RESPONSE TO EXTERNAL STIMULUS 76 1821 8.651e-05 0.00234
173 POSITIVE REGULATION OF OSSIFICATION 10 84 8.717e-05 0.002345
174 SMOOTH MUSCLE TISSUE DEVELOPMENT 5 18 9.016e-05 0.002411
175 POSITIVE REGULATION OF CHEMOTAXIS 12 120 9.932e-05 0.002641
176 REGULATION OF EPITHELIAL CELL PROLIFERATION 20 285 0.0001028 0.002718
177 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 53 1152 0.0001076 0.002781
178 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 10 86 0.0001065 0.002781
179 CRANIAL SKELETAL SYSTEM DEVELOPMENT 8 55 0.0001069 0.002781
180 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 9 70 0.0001073 0.002781
181 FOREBRAIN DEVELOPMENT 23 357 0.0001169 0.002969
182 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 12 122 0.0001165 0.002969
183 CELL PROJECTION ORGANIZATION 44 902 0.0001174 0.002969
184 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 11 104 0.0001161 0.002969
185 POSITIVE REGULATION OF KINASE ACTIVITY 28 482 0.0001321 0.003308
186 REGULATION OF NEURON PROJECTION DEVELOPMENT 25 408 0.0001322 0.003308
187 KIDNEY EPITHELIUM DEVELOPMENT 12 125 0.000147 0.003657
188 OLFACTORY BULB INTERNEURON DEVELOPMENT 4 11 0.0001491 0.003691
189 REGULATION OF KINASE ACTIVITY 39 776 0.0001567 0.003798
190 RELAXATION OF MUSCLE 5 20 0.000156 0.003798
191 ENDOTHELIUM DEVELOPMENT 10 90 0.0001564 0.003798
192 MESONEPHROS DEVELOPMENT 10 90 0.0001564 0.003798
193 TAXIS 27 464 0.0001687 0.004068
194 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 14 166 0.0001708 0.004096
195 OSSIFICATION 18 251 0.0001722 0.00411
196 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 27 465 0.0001747 0.004147
197 REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 9 75 0.0001839 0.004343
198 METANEPHRIC NEPHRON DEVELOPMENT 6 32 0.0001878 0.004413
199 REGULATION OF AXONOGENESIS 14 168 0.0001936 0.004528
200 CHONDROCYTE DIFFERENTIATION 8 60 0.0001996 0.004644
201 MUSCLE ORGAN DEVELOPMENT 19 277 0.000204 0.004699
202 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 10 93 0.0002055 0.004699
203 APPENDAGE DEVELOPMENT 14 169 0.000206 0.004699
204 LIMB DEVELOPMENT 14 169 0.000206 0.004699
205 NEGATIVE REGULATION OF CELL GROWTH 14 170 0.0002191 0.004972
206 EMBRYONIC DIGESTIVE TRACT DEVELOPMENT 6 33 0.0002243 0.004998
207 ACTION POTENTIAL 10 94 0.0002245 0.004998
208 RESPONSE TO BMP 10 94 0.0002245 0.004998
209 CELLULAR RESPONSE TO BMP STIMULUS 10 94 0.0002245 0.004998
210 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 10 95 0.000245 0.005415
211 NEGATIVE REGULATION OF GROWTH 17 236 0.0002456 0.005415
212 STRIATED MUSCLE CELL DIFFERENTIATION 14 173 0.0002626 0.005764
213 REGULATION OF CARTILAGE DEVELOPMENT 8 63 0.0002815 0.006123
214 REGULATION OF MYOBLAST DIFFERENTIATION 7 48 0.0002837 0.006123
215 MESENCHYMAL CELL DIFFERENTIATION 12 134 0.0002825 0.006123
216 CELLULAR RESPONSE TO NITROGEN COMPOUND 28 505 0.0002842 0.006123
217 GLAND MORPHOGENESIS 10 97 0.0002906 0.006231
218 HOMEOSTASIS OF NUMBER OF CELLS 14 175 0.0002956 0.006309
219 NEGATIVE REGULATION OF LOCOMOTION 18 263 0.0003054 0.006315
220 REGULATION OF RESPONSE TO STRESS 62 1468 0.0002996 0.006315
221 GASTRULATION 13 155 0.0003049 0.006315
222 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 16 218 0.0003006 0.006315
223 CELLULAR RESPONSE TO MECHANICAL STIMULUS 9 80 0.0003014 0.006315
224 CELL GROWTH 12 135 0.0003026 0.006315
225 CELLULAR RESPONSE TO ABIOTIC STIMULUS 18 263 0.0003054 0.006315
226 CELLULAR RESPONSE TO LIPID 26 457 0.0003139 0.006464
227 CELLULAR RESPONSE TO EXTERNAL STIMULUS 18 264 0.0003197 0.006554
228 REGULATION OF ORGAN MORPHOGENESIS 17 242 0.0003294 0.006722
229 REGULATION OF ACTIN FILAMENT BASED PROCESS 20 312 0.0003412 0.006933
230 CELL PROLIFERATION 34 672 0.0003639 0.007363
231 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 7 50 0.0003674 0.007388
232 POSITIVE REGULATION OF AXON EXTENSION 6 36 0.0003684 0.007388
233 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 10 100 0.0003722 0.007433
234 NEGATIVE REGULATION OF CELL ADHESION 16 223 0.000387 0.007695
235 NEGATIVE REGULATION OF CHEMOTAXIS 7 51 0.0004161 0.008238
236 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 4 14 0.0004241 0.008361
237 CELL COMMUNICATION INVOLVED IN CARDIAC CONDUCTION 6 37 0.0004297 0.008366
238 CARDIAC MUSCLE CELL ACTION POTENTIAL 6 37 0.0004297 0.008366
239 NEGATIVE REGULATION OF EPITHELIAL CELL DIFFERENTIATION 6 37 0.0004297 0.008366
240 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 10 102 0.0004366 0.008464
241 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 11 121 0.000441 0.008514
242 REGULATION OF PROTEIN IMPORT 14 183 0.0004655 0.00895
243 EPITHELIAL CELL DIFFERENTIATION 27 495 0.0004677 0.008955
244 HEART PROCESS 9 85 0.0004752 0.009024
245 NEURON PROJECTION GUIDANCE 15 205 0.0004745 0.009024
246 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 26 470 0.0004801 0.009081
247 POSITIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 6 38 0.0004988 0.009359
248 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 18 274 0.0004985 0.009359
249 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 7 53 0.0005288 0.009882
250 CELLULAR RESPONSE TO HORMONE STIMULUS 29 552 0.0005362 0.009979
NumGOOverlapSizeP ValueAdj. P Value
1 REGULATORY REGION NUCLEIC ACID BINDING 54 818 1.339e-09 9.382e-07
2 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 45 629 3.03e-09 9.382e-07
3 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 69 1199 2.112e-09 9.382e-07
4 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 28 328 8.933e-08 2.075e-05
5 TRANSCRIPTION FACTOR BINDING 35 524 9.145e-07 0.0001699
6 DOUBLE STRANDED DNA BINDING 44 764 2.081e-06 0.0003222
7 E BOX BINDING 8 34 2.621e-06 0.0003253
8 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 24 303 2.801e-06 0.0003253
9 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 24 315 5.464e-06 0.000564
10 CORE PROMOTER PROXIMAL REGION DNA BINDING 26 371 1.008e-05 0.0009362
11 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 19 226 1.31e-05 0.001106
12 MOLECULAR FUNCTION REGULATOR 63 1353 1.614e-05 0.00125
13 RECEPTOR SIGNALING PROTEIN ACTIVITY 16 172 1.806e-05 0.00129
14 KINASE ACTIVITY 44 842 2.378e-05 0.001489
15 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 12 104 2.405e-05 0.001489
16 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 34 588 2.833e-05 0.001645
17 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 11 92 3.743e-05 0.002046
18 RHO GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 10 77 4.099e-05 0.002116
19 TRANSFORMING GROWTH FACTOR BETA BINDING 5 16 4.807e-05 0.00235
20 CALCIUM ION BINDING 37 697 7.734e-05 0.003592
21 BHLH TRANSCRIPTION FACTOR BINDING 6 28 8.556e-05 0.003785
22 PROTEIN DIMERIZATION ACTIVITY 53 1149 0.0001007 0.004252
23 SMAD BINDING 9 72 0.0001338 0.005356
24 ACTIVATING TRANSCRIPTION FACTOR BINDING 8 57 0.0001384 0.005356
25 PROTEIN KINASE ACTIVITY 34 640 0.0001482 0.005508
26 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 17 228 0.000163 0.005824
27 STEROID HORMONE RECEPTOR ACTIVITY 8 59 0.0001771 0.006095
28 CYTOKINE BINDING 10 92 0.0001878 0.006232
29 SEQUENCE SPECIFIC DNA BINDING 48 1037 0.0001992 0.006383
30 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 46 992 0.0002601 0.008056
31 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 7 48 0.0002837 0.008236
32 ENZYME BINDING 71 1737 0.0002793 0.008236
33 PROTEIN HOMODIMERIZATION ACTIVITY 36 722 0.0003242 0.009128
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 60 1151 7.884e-07 0.0002302
2 ANCHORING JUNCTION 34 489 5.287e-07 0.0002302
3 CELL SUBSTRATE JUNCTION 29 398 1.441e-06 0.0002806
4 INTRINSIC COMPONENT OF PLASMA MEMBRANE 75 1649 5.36e-06 0.0007826
5 CELL CELL CONTACT ZONE 10 64 7.745e-06 0.0009046
6 MEMBRANE MICRODOMAIN 22 288 1.284e-05 0.001249
7 T TUBULE 8 45 2.397e-05 0.002
8 MEMBRANE REGION 54 1134 3.737e-05 0.002728
9 CYTOSKELETON 80 1967 0.0001295 0.006876
10 CELL CELL JUNCTION 24 383 0.0001279 0.006876
11 PLASMA MEMBRANE RAFT 10 86 0.0001065 0.006876
12 SARCOLEMMA 12 125 0.000147 0.007042
13 MAIN AXON 8 58 0.0001568 0.007042
14 CELL SURFACE 38 757 0.0001946 0.008117

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 23 295 5.854e-06 0.0003044
2 FoxO_signaling_pathway_hsa04068 13 132 6.036e-05 0.001569
3 Focal_adhesion_hsa04510 16 199 0.0001056 0.00183
4 TNF_signaling_pathway_hsa04668 11 108 0.0001631 0.00212
5 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 12 139 0.0003957 0.00377
6 TGF_beta_signaling_pathway_hsa04350 9 84 0.0004351 0.00377
7 Hippo_signaling_pathway_multiple_species_hsa04392 5 29 0.0009779 0.00665
8 Endocytosis_hsa04144 16 244 0.001023 0.00665
9 ECM_receptor_interaction_hsa04512 8 82 0.001659 0.009584
10 Oocyte_meiosis_hsa04114 10 124 0.001978 0.01028
11 Gap_junction_hsa04540 8 88 0.0026 0.01169
12 mTOR_signaling_pathway_hsa04150 11 151 0.002697 0.01169
13 Hippo_signaling_pathway_hsa04390 11 154 0.00314 0.01256
14 Regulation_of_actin_cytoskeleton_hsa04810 13 208 0.004412 0.01639
15 Rap1_signaling_pathway_hsa04015 12 206 0.01041 0.03278
16 Ras_signaling_pathway_hsa04014 13 232 0.01066 0.03278
17 Calcium_signaling_pathway_hsa04020 11 182 0.01072 0.03278
18 Apoptosis_hsa04210 9 138 0.0127 0.03628
19 cGMP_PKG_signaling_pathway_hsa04022 10 163 0.01325 0.03628
20 Cytokine_cytokine_receptor_interaction_hsa04060 14 270 0.01543 0.03848
21 PI3K_Akt_signaling_pathway_hsa04151 17 352 0.01557 0.03848
22 Cell_adhesion_molecules_.CAMs._hsa04514 9 145 0.01706 0.03848
23 Tight_junction_hsa04530 10 170 0.01732 0.03848
24 Wnt_signaling_pathway_hsa04310 9 146 0.01776 0.03848
25 Ferroptosis_hsa04216 4 40 0.0223 0.04638
26 p53_signaling_pathway_hsa04115 5 68 0.03657 0.07314
27 Sphingolipid_signaling_pathway_hsa04071 7 118 0.04099 0.07894
28 cAMP_signaling_pathway_hsa04024 10 198 0.04302 0.0799
29 Phospholipase_D_signaling_pathway_hsa04072 8 146 0.04476 0.08026
30 Phagosome_hsa04145 8 152 0.05433 0.09418
31 Autophagy_animal_hsa04140 7 128 0.05875 0.09855
32 Cellular_senescence_hsa04218 8 160 0.069 0.1121
33 Apelin_signaling_pathway_hsa04371 7 137 0.07825 0.1224
34 ErbB_signaling_pathway_hsa04012 5 85 0.08001 0.1224
35 Phosphatidylinositol_signaling_system_hsa04070 5 99 0.1299 0.1878
36 Adherens_junction_hsa04520 4 72 0.13 0.1878
37 HIF_1_signaling_pathway_hsa04066 5 100 0.1339 0.1882
38 Jak_STAT_signaling_pathway_hsa04630 7 162 0.1496 0.2047
39 Necroptosis_hsa04217 7 164 0.1563 0.2084
40 Peroxisome_hsa04146 4 83 0.1863 0.2422
41 VEGF_signaling_pathway_hsa04370 3 59 0.2132 0.2704
42 Apoptosis_multiple_species_hsa04215 2 33 0.2236 0.2769
43 AMPK_signaling_pathway_hsa04152 5 121 0.2292 0.2771
44 NF_kappa_B_signaling_pathway_hsa04064 4 95 0.2549 0.3012
45 ABC_transporters_hsa02010 2 45 0.3439 0.3974
46 Notch_signaling_pathway_hsa04330 2 48 0.3733 0.422
47 Lysosome_hsa04142 4 123 0.4255 0.4707
48 Cell_cycle_hsa04110 3 124 0.6546 0.7091
49 Neuroactive_ligand_receptor_interaction_hsa04080 6 278 0.7649 0.7955

Quest ID: 03d7d79e31ef29bbb45382958ad89ba4