This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | hsa-miR-15a-5p | ABL2 | -0.14 | 0.05362 | 0.12 | 0.01311 | MirTarget; miRNATAP | -0.17 | 0 | NA | |
2 | hsa-miR-15a-5p | ACOX1 | -0.14 | 0.05362 | 0.07 | 0.18823 | miRNATAP | -0.13 | 0 | NA | |
3 | hsa-miR-15a-5p | ACVR2B | -0.14 | 0.05362 | 0.26 | 0.0002 | miRNATAP | -0.36 | 0 | NA | |
4 | hsa-miR-15a-5p | ADAMTS5 | -0.14 | 0.05362 | 0.25 | 0.0171 | miRNATAP | -0.44 | 0 | NA | |
5 | hsa-miR-15a-5p | ADAMTSL3 | -0.14 | 0.05362 | 0.38 | 0.00318 | MirTarget | -0.21 | 0.02037 | NA | |
6 | hsa-miR-15a-5p | ADCY5 | -0.14 | 0.05362 | 0.4 | 1.0E-5 | MirTarget; miRNATAP | -0.13 | 0.03856 | NA | |
7 | hsa-miR-15a-5p | AHCYL2 | -0.14 | 0.05362 | 0.26 | 0.00064 | miRNATAP | -0.14 | 0.00169 | NA | |
8 | hsa-miR-15a-5p | AKT3 | -0.14 | 0.05362 | 0.24 | 0.00086 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.17 | 0.0001 | NA | |
9 | hsa-miR-15a-5p | AMOTL1 | -0.14 | 0.05362 | 0.15 | 0.02214 | MirTarget; miRNATAP | -0.2 | 0 | NA | |
10 | hsa-miR-15a-5p | ANAPC16 | -0.14 | 0.05362 | 0.17 | 0.00053 | miRNAWalker2 validate | -0.11 | 3.0E-5 | NA | |
11 | hsa-miR-15a-5p | ANKRD13B | -0.14 | 0.05362 | 0.09 | 0.14467 | miRNATAP | -0.19 | 0 | NA | |
12 | hsa-miR-15a-5p | ANKRD46 | -0.14 | 0.05362 | 0.33 | 0 | MirTarget | -0.21 | 0 | NA | |
13 | hsa-miR-15a-5p | ANO3 | -0.14 | 0.05362 | 0.68 | 6.0E-5 | MirTarget; miRNATAP | -0.35 | 0.00473 | NA | |
14 | hsa-miR-15a-5p | AQP11 | -0.14 | 0.05362 | 0.06 | 0.16264 | MirTarget | -0.14 | 0 | NA | |
15 | hsa-miR-15a-5p | ARHGAP12 | -0.14 | 0.05362 | 0.23 | 0.00014 | miRNATAP | -0.29 | 0 | NA | |
16 | hsa-miR-15a-5p | ARHGAP32 | -0.14 | 0.05362 | 0.39 | 0 | MirTarget | -0.21 | 0 | NA | |
17 | hsa-miR-15a-5p | ARHGAP5 | -0.14 | 0.05362 | 0.27 | 2.0E-5 | MirTarget; miRNATAP | -0.16 | 1.0E-5 | NA | |
18 | hsa-miR-15a-5p | ARHGEF7 | -0.14 | 0.05362 | 0.2 | 0.00262 | mirMAP | -0.12 | 0.00071 | NA | |
19 | hsa-miR-15a-5p | ARHGEF9 | -0.14 | 0.05362 | 0.26 | 9.0E-5 | miRNATAP | -0.11 | 0.0068 | NA | |
20 | hsa-miR-15a-5p | ARL3 | -0.14 | 0.05362 | 0.42 | 0 | MirTarget | -0.29 | 0 | NA | |
21 | hsa-miR-15a-5p | ARNT2 | -0.14 | 0.05362 | 0.28 | 3.0E-5 | mirMAP | -0.13 | 0.00012 | NA | |
22 | hsa-miR-15a-5p | ASB1 | -0.14 | 0.05362 | 0.22 | 0.00013 | MirTarget; miRNATAP | -0.12 | 0.00094 | NA | |
23 | hsa-miR-15a-5p | ASH1L | -0.14 | 0.05362 | 0.19 | 0.00262 | MirTarget; miRNATAP | -0.16 | 0 | NA | |
24 | hsa-miR-15a-5p | ASTN1 | -0.14 | 0.05362 | 0.2 | 0.0215 | MirTarget | -0.14 | 0.00652 | NA | |
25 | hsa-miR-15a-5p | ATF2 | -0.14 | 0.05362 | 0.07 | 0.33393 | miRNAWalker2 validate | -0.14 | 0.00412 | NA | |
26 | hsa-miR-15a-5p | ATP2B2 | -0.14 | 0.05362 | 0.46 | 1.0E-5 | MirTarget; miRNATAP | -0.17 | 0.02279 | NA | |
27 | hsa-miR-15a-5p | ATP8A1 | -0.14 | 0.05362 | 0.61 | 0 | MirTarget | -0.18 | 0.00441 | NA | |
28 | hsa-miR-15a-5p | ATXN7L2 | -0.14 | 0.05362 | 0.01 | 0.89891 | MirTarget; miRNATAP | -0.11 | 0.02572 | NA | |
29 | hsa-miR-15a-5p | ATXN7L3B | -0.14 | 0.05362 | 0.18 | 0.00137 | MirTarget | -0.1 | 0.00019 | NA | |
30 | hsa-miR-15a-5p | AVL9 | -0.14 | 0.05362 | 0.01 | 0.87129 | MirTarget; miRNATAP | -0.16 | 0.00148 | NA | |
31 | hsa-miR-15a-5p | AXIN2 | -0.14 | 0.05362 | 0.25 | 5.0E-5 | MirTarget; miRNATAP | -0.22 | 0 | 26252081 | The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy |
32 | hsa-miR-15a-5p | BACH2 | -0.14 | 0.05362 | -0.06 | 0.32181 | MirTarget; miRNATAP | -0.12 | 0.00617 | NA | |
33 | hsa-miR-15a-5p | BAG4 | -0.14 | 0.05362 | 0.14 | 0.09377 | MirTarget | -0.16 | 0.00785 | NA | |
34 | hsa-miR-15a-5p | BCL11B | -0.14 | 0.05362 | 0.52 | 0 | MirTarget | -0.24 | 0.00194 | NA | |
35 | hsa-miR-15a-5p | BCL2 | -0.14 | 0.05362 | 0.19 | 0.00385 | miRNAWalker2 validate; miRTarBase | -0.15 | 0.00052 | 25594541; 26915294; 18931683; 25623762; 22335947 | MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 |
36 | hsa-miR-15a-5p | BPTF | -0.14 | 0.05362 | 0.02 | 0.68617 | miRNATAP | -0.12 | 0.00015 | NA | |
37 | hsa-miR-15a-5p | BRD3 | -0.14 | 0.05362 | 0.08 | 0.14277 | mirMAP | -0.21 | 0 | NA | |
38 | hsa-miR-15a-5p | BRPF3 | -0.14 | 0.05362 | 0.12 | 0.05233 | miRNATAP | -0.14 | 0.00029 | NA | |
39 | hsa-miR-15a-5p | BRSK2 | -0.14 | 0.05362 | 0.44 | 0 | mirMAP | -0.3 | 1.0E-5 | NA | |
40 | hsa-miR-15a-5p | BRWD3 | -0.14 | 0.05362 | -0.07 | 0.49067 | MirTarget | -0.22 | 0.00106 | NA | |
41 | hsa-miR-15a-5p | BTAF1 | -0.14 | 0.05362 | 0.15 | 0.02765 | MirTarget | -0.2 | 0 | NA | |
42 | hsa-miR-15a-5p | BTRC | -0.14 | 0.05362 | 0.32 | 0 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.2 | 0 | NA | |
43 | hsa-miR-15a-5p | C1orf21 | -0.14 | 0.05362 | 0.14 | 0.0272 | mirMAP; miRNATAP | -0.1 | 0.00612 | NA | |
44 | hsa-miR-15a-5p | C2orf72 | -0.14 | 0.05362 | 0.16 | 0.02282 | miRNATAP | -0.13 | 0.00506 | NA | |
45 | hsa-miR-15a-5p | CACNA1E | -0.14 | 0.05362 | 0.57 | 0.0001 | MirTarget | -0.4 | 0.00012 | NA | |
46 | hsa-miR-15a-5p | CALN1 | -0.14 | 0.05362 | 1.22 | 0 | mirMAP | -0.7 | 0 | NA | |
47 | hsa-miR-15a-5p | CAMSAP1 | -0.14 | 0.05362 | 0.07 | 0.16428 | MirTarget; miRNATAP | -0.13 | 0 | NA | |
48 | hsa-miR-15a-5p | CASK | -0.14 | 0.05362 | 0.16 | 0.01486 | MirTarget; miRNATAP | -0.23 | 0 | NA | |
49 | hsa-miR-15a-5p | CASKIN1 | -0.14 | 0.05362 | 0.74 | 0 | miRNATAP | -0.45 | 0 | NA | |
50 | hsa-miR-15a-5p | CASP9 | -0.14 | 0.05362 | 0.19 | 0.00861 | mirMAP | -0.24 | 0 | NA | |
51 | hsa-miR-15a-5p | CASZ1 | -0.14 | 0.05362 | -0.06 | 0.59914 | MirTarget | -0.25 | 0.00172 | NA | |
52 | hsa-miR-15a-5p | CBFA2T3 | -0.14 | 0.05362 | 0.38 | 1.0E-5 | MirTarget; miRNATAP | -0.22 | 0.00018 | NA | |
53 | hsa-miR-15a-5p | CCDC6 | -0.14 | 0.05362 | 0.18 | 0.00033 | MirTarget; miRNATAP | -0.11 | 3.0E-5 | NA | |
54 | hsa-miR-15a-5p | CCDC85C | -0.14 | 0.05362 | 0.36 | 0 | MirTarget | -0.26 | 0 | NA | |
55 | hsa-miR-15a-5p | CCNJ | -0.14 | 0.05362 | -0.04 | 0.44486 | miRNATAP | -0.12 | 0.00032 | NA | |
56 | hsa-miR-15a-5p | CCT6B | -0.14 | 0.05362 | 0.27 | 1.0E-5 | miRNAWalker2 validate | -0.15 | 0.00081 | NA | |
57 | hsa-miR-15a-5p | CDC14B | -0.14 | 0.05362 | 0 | 0.9326 | miRNAWalker2 validate; MirTarget | -0.11 | 6.0E-5 | NA | |
58 | hsa-miR-15a-5p | CDC37L1 | -0.14 | 0.05362 | 0.15 | 0.00032 | MirTarget; miRNATAP | -0.11 | 5.0E-5 | NA | |
59 | hsa-miR-15a-5p | CDK5R1 | -0.14 | 0.05362 | 0.39 | 0.00013 | MirTarget; miRNATAP | -0.37 | 0 | NA | |
60 | hsa-miR-15a-5p | CDS2 | -0.14 | 0.05362 | 0.13 | 0.01227 | mirMAP; miRNATAP | -0.14 | 0 | NA | |
61 | hsa-miR-15a-5p | CECR6 | -0.14 | 0.05362 | 0.27 | 0.00061 | MirTarget; miRNATAP | -0.27 | 0 | NA | |
62 | hsa-miR-15a-5p | CEP350 | -0.14 | 0.05362 | 0.14 | 0.01879 | miRNATAP | -0.13 | 7.0E-5 | NA | |
63 | hsa-miR-15a-5p | CHD2 | -0.14 | 0.05362 | 0.07 | 0.2131 | MirTarget | -0.11 | 1.0E-5 | NA | |
64 | hsa-miR-15a-5p | CHD5 | -0.14 | 0.05362 | 0.9 | 0 | miRNATAP | -0.33 | 0.01493 | NA | |
65 | hsa-miR-15a-5p | CHD9 | -0.14 | 0.05362 | 0.05 | 0.43798 | miRNATAP | -0.14 | 0.00033 | NA | |
66 | hsa-miR-15a-5p | CHUK | -0.14 | 0.05362 | 0.08 | 0.04445 | miRNAWalker2 validate; miRTarBase; MirTarget | -0.11 | 0 | NA | |
67 | hsa-miR-15a-5p | CNKSR2 | -0.14 | 0.05362 | 0.47 | 0.0001 | miRNATAP | -0.21 | 0.01597 | NA | |
68 | hsa-miR-15a-5p | COX15 | -0.14 | 0.05362 | 0.18 | 0.00014 | MirTarget | -0.17 | 0 | NA | |
69 | hsa-miR-15a-5p | CPEB3 | -0.14 | 0.05362 | 0.56 | 0 | MirTarget; miRNATAP | -0.32 | 0 | NA | |
70 | hsa-miR-15a-5p | CPSF7 | -0.14 | 0.05362 | 0.07 | 0.13095 | MirTarget; miRNATAP | -0.12 | 0 | NA | |
71 | hsa-miR-15a-5p | CRKL | -0.14 | 0.05362 | 0.09 | 0.08948 | miRTarBase; MirTarget; miRNATAP | -0.13 | 0 | NA | |
72 | hsa-miR-15a-5p | CSF1 | -0.14 | 0.05362 | 0.12 | 0.20838 | miRNATAP | -0.18 | 0.00668 | NA | |
73 | hsa-miR-15a-5p | CUL2 | -0.14 | 0.05362 | 0.15 | 0.00071 | MirTarget; miRNATAP | -0.1 | 3.0E-5 | NA | |
74 | hsa-miR-15a-5p | CX3CL1 | -0.14 | 0.05362 | 0.2 | 0.0062 | miRNATAP | -0.18 | 7.0E-5 | NA | |
75 | hsa-miR-15a-5p | CYS1 | -0.14 | 0.05362 | 0.74 | 0 | mirMAP | -0.25 | 0.00101 | NA | |
76 | hsa-miR-15a-5p | DCAF5 | -0.14 | 0.05362 | 0.16 | 0.00087 | MirTarget; miRNATAP | -0.16 | 0 | NA | |
77 | hsa-miR-15a-5p | DCAF7 | -0.14 | 0.05362 | -0 | 0.95508 | miRNATAP | -0.15 | 0 | NA | |
78 | hsa-miR-15a-5p | DCLK1 | -0.14 | 0.05362 | 0.49 | 0 | miRNATAP | -0.17 | 0.01602 | NA | |
79 | hsa-miR-15a-5p | DCX | -0.14 | 0.05362 | 0.35 | 0.02122 | mirMAP | -0.58 | 0 | NA | |
80 | hsa-miR-15a-5p | DENND1B | -0.14 | 0.05362 | -0.03 | 0.68777 | miRNATAP | -0.15 | 0.00126 | NA | |
81 | hsa-miR-15a-5p | DGCR2 | -0.14 | 0.05362 | 0.25 | 0.00027 | mirMAP | -0.18 | 0 | NA | |
82 | hsa-miR-15a-5p | DLL1 | -0.14 | 0.05362 | 0.29 | 0.00828 | miRNATAP | -0.59 | 0 | NA | |
83 | hsa-miR-15a-5p | EDA | -0.14 | 0.05362 | 0.33 | 0 | MirTarget; miRNATAP | -0.11 | 0.03005 | NA | |
84 | hsa-miR-15a-5p | EIF3A | -0.14 | 0.05362 | 0.08 | 0.18481 | MirTarget; miRNATAP | -0.12 | 4.0E-5 | NA | |
85 | hsa-miR-15a-5p | EIF4B | -0.14 | 0.05362 | 0.15 | 0.02719 | miRNATAP | -0.16 | 1.0E-5 | NA | |
86 | hsa-miR-15a-5p | ELMO2 | -0.14 | 0.05362 | 0.12 | 0.02299 | miRNATAP | -0.12 | 0 | NA | |
87 | hsa-miR-15a-5p | ENAH | -0.14 | 0.05362 | -0.04 | 0.60098 | MirTarget; miRNATAP | -0.19 | 0 | NA | |
88 | hsa-miR-15a-5p | EPB41L5 | -0.14 | 0.05362 | 0.02 | 0.70936 | MirTarget | -0.1 | 0.00082 | NA | |
89 | hsa-miR-15a-5p | ERC2 | -0.14 | 0.05362 | 0.5 | 0 | MirTarget; miRNATAP | -0.32 | 2.0E-5 | NA | |
90 | hsa-miR-15a-5p | ERCC6 | -0.14 | 0.05362 | 0.16 | 0.00387 | MirTarget | -0.18 | 0 | NA | |
91 | hsa-miR-15a-5p | EYA1 | -0.14 | 0.05362 | 0.87 | 0 | miRNATAP | -0.86 | 0 | NA | |
92 | hsa-miR-15a-5p | FAM120C | -0.14 | 0.05362 | 0.14 | 0.00494 | MirTarget; miRNATAP | -0.16 | 0 | NA | |
93 | hsa-miR-15a-5p | FAM60A | -0.14 | 0.05362 | -0.26 | 0.00567 | miRNATAP | -0.15 | 0.0194 | NA | |
94 | hsa-miR-15a-5p | FAM69A | -0.14 | 0.05362 | 0.43 | 0 | miRNAWalker2 validate | -0.16 | 0.00319 | NA | |
95 | hsa-miR-15a-5p | FAM84B | -0.14 | 0.05362 | 0.24 | 0.02718 | MirTarget | -0.38 | 0 | NA | |
96 | hsa-miR-15a-5p | FASN | -0.14 | 0.05362 | 0.25 | 0.00074 | miRNAWalker2 validate; MirTarget | -0.18 | 1.0E-5 | 27713175 | Both miR-15a and miR-16-1 contributes to inhibiting FASN expression and breast cancer cell proliferation; In conclusion we demonstrated that FASN expression is primarily downregulated by miR-15a and miR-16-1 in mammary cells and FASN is one of the major targets of these two tumor suppressive microRNAs |
97 | hsa-miR-15a-5p | FAT3 | -0.14 | 0.05362 | 0.36 | 0.0001 | MirTarget; miRNATAP | -0.33 | 0 | NA | |
98 | hsa-miR-15a-5p | FAT4 | -0.14 | 0.05362 | 0.1 | 0.30301 | MirTarget | -0.17 | 0.00831 | NA | |
99 | hsa-miR-15a-5p | FBXO21 | -0.14 | 0.05362 | 0.07 | 0.22868 | MirTarget; miRNATAP | -0.18 | 0 | NA | |
100 | hsa-miR-15a-5p | FCHSD2 | -0.14 | 0.05362 | 0.25 | 0.00061 | miRNATAP | -0.33 | 0 | NA | |
101 | hsa-miR-15a-5p | FGF2 | -0.14 | 0.05362 | 0.31 | 1.0E-5 | MirTarget; miRNATAP | -0.21 | 0 | 21532615 | Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration |
102 | hsa-miR-15a-5p | FGF9 | -0.14 | 0.05362 | 0.6 | 5.0E-5 | miRNATAP | -0.28 | 0.00935 | NA | |
103 | hsa-miR-15a-5p | FRMPD1 | -0.14 | 0.05362 | 0.48 | 1.0E-5 | MirTarget | -0.5 | 0 | NA | |
104 | hsa-miR-15a-5p | FRY | -0.14 | 0.05362 | 0.41 | 0 | miRNATAP | -0.3 | 0 | NA | |
105 | hsa-miR-15a-5p | FSD1 | -0.14 | 0.05362 | 0.24 | 0.00734 | MirTarget; miRNATAP | -0.22 | 0.00027 | NA | |
106 | hsa-miR-15a-5p | GABRA1 | -0.14 | 0.05362 | 1.01 | 0.00014 | miRNATAP | -0.41 | 0.03179 | NA | |
107 | hsa-miR-15a-5p | GALNT13 | -0.14 | 0.05362 | 0.78 | 0 | MirTarget | -0.82 | 0 | NA | |
108 | hsa-miR-15a-5p | GHR | -0.14 | 0.05362 | 0.17 | 0.06404 | MirTarget; miRNATAP | -0.28 | 1.0E-5 | NA | |
109 | hsa-miR-15a-5p | GLUD1 | -0.14 | 0.05362 | 0.6 | 0 | MirTarget; miRNATAP | -0.47 | 0 | NA | |
110 | hsa-miR-15a-5p | GNAL | -0.14 | 0.05362 | 0.84 | 0 | miRNATAP | -0.64 | 0 | NA | |
111 | hsa-miR-15a-5p | GNAO1 | -0.14 | 0.05362 | 0.4 | 0 | mirMAP | -0.19 | 0.00011 | NA | |
112 | hsa-miR-15a-5p | GORASP1 | -0.14 | 0.05362 | 0.21 | 5.0E-5 | MirTarget | -0.11 | 8.0E-5 | NA | |
113 | hsa-miR-15a-5p | GPR153 | -0.14 | 0.05362 | 0.22 | 0.04826 | miRNATAP | -0.29 | 0.00016 | NA | |
114 | hsa-miR-15a-5p | GPRIN2 | -0.14 | 0.05362 | 0.73 | 0 | mirMAP | -0.21 | 0.03819 | NA | |
115 | hsa-miR-15a-5p | GRAMD3 | -0.14 | 0.05362 | 0.36 | 2.0E-5 | MirTarget | -0.19 | 0.00024 | NA | |
116 | hsa-miR-15a-5p | GTPBP1 | -0.14 | 0.05362 | 0.08 | 0.13085 | MirTarget | -0.13 | 0 | NA | |
117 | hsa-miR-15a-5p | HAS2 | -0.14 | 0.05362 | -0.51 | 0.00062 | MirTarget | -0.22 | 0.04279 | NA | |
118 | hsa-miR-15a-5p | HECTD1 | -0.14 | 0.05362 | 0.16 | 0.00456 | miRNATAP | -0.11 | 6.0E-5 | NA | |
119 | hsa-miR-15a-5p | HHIPL1 | -0.14 | 0.05362 | 0.36 | 0 | mirMAP | -0.12 | 0.00688 | NA | |
120 | hsa-miR-15a-5p | HIPK2 | -0.14 | 0.05362 | 0.36 | 1.0E-5 | miRNATAP | -0.26 | 0 | NA | |
121 | hsa-miR-15a-5p | HIRA | -0.14 | 0.05362 | 0.13 | 0.00442 | MirTarget; miRNATAP | -0.13 | 0 | NA | |
122 | hsa-miR-15a-5p | HNRNPA1 | -0.14 | 0.05362 | 0.07 | 0.27756 | miRNATAP | -0.12 | 0.00032 | NA | |
123 | hsa-miR-15a-5p | HPCAL4 | -0.14 | 0.05362 | 0.98 | 0 | MirTarget | -0.38 | 0.00154 | NA | |
124 | hsa-miR-15a-5p | HPSE2 | -0.14 | 0.05362 | 2.23 | 0 | MirTarget | -1.45 | 0 | NA | |
125 | hsa-miR-15a-5p | HSDL2 | -0.14 | 0.05362 | 0.24 | 8.0E-5 | miRNAWalker2 validate | -0.12 | 0.00059 | NA | |
126 | hsa-miR-15a-5p | HTR2A | -0.14 | 0.05362 | 1.17 | 0 | MirTarget | -0.61 | 0 | NA | |
127 | hsa-miR-15a-5p | IGF1R | -0.14 | 0.05362 | 0.14 | 0.0366 | miRNATAP | -0.22 | 0 | NA | |
128 | hsa-miR-15a-5p | IGSF9B | -0.14 | 0.05362 | -0.01 | 0.95586 | mirMAP | -0.2 | 0.03701 | NA | |
129 | hsa-miR-15a-5p | IPO7 | -0.14 | 0.05362 | 0.07 | 0.29652 | MirTarget; miRNATAP | -0.18 | 0 | NA | |
130 | hsa-miR-15a-5p | JARID2 | -0.14 | 0.05362 | 0.14 | 0.00609 | MirTarget; miRNATAP | -0.2 | 0 | NA | |
131 | hsa-miR-15a-5p | KBTBD4 | -0.14 | 0.05362 | 0.11 | 0.03379 | miRNATAP | -0.11 | 0.00051 | NA | |
132 | hsa-miR-15a-5p | KCNA6 | -0.14 | 0.05362 | 0.19 | 0.03684 | MirTarget | -0.14 | 0.01997 | NA | |
133 | hsa-miR-15a-5p | KCNC2 | -0.14 | 0.05362 | 0.7 | 0.00595 | MirTarget; miRNATAP | -0.43 | 0.01992 | NA | |
134 | hsa-miR-15a-5p | KCNK3 | -0.14 | 0.05362 | 0.75 | 1.0E-5 | mirMAP | -0.56 | 0 | NA | |
135 | hsa-miR-15a-5p | KCNQ5 | -0.14 | 0.05362 | 0.7 | 0 | miRNATAP | -0.59 | 0 | NA | |
136 | hsa-miR-15a-5p | KIAA1147 | -0.14 | 0.05362 | 0.35 | 0 | mirMAP | -0.17 | 0 | NA | |
137 | hsa-miR-15a-5p | KIAA1644 | -0.14 | 0.05362 | 1.05 | 0 | mirMAP | -0.6 | 1.0E-5 | NA | |
138 | hsa-miR-15a-5p | KIAA2022 | -0.14 | 0.05362 | 0.41 | 0.00032 | MirTarget; miRNATAP | -0.3 | 0.00021 | NA | |
139 | hsa-miR-15a-5p | KIF1A | -0.14 | 0.05362 | 0.54 | 0 | miRNAWalker2 validate | -0.22 | 2.0E-5 | NA | |
140 | hsa-miR-15a-5p | KIF1B | -0.14 | 0.05362 | 0.26 | 0.00052 | miRNATAP | -0.23 | 0 | NA | |
141 | hsa-miR-15a-5p | KLHDC8B | -0.14 | 0.05362 | 0.12 | 0.0252 | MirTarget | -0.11 | 0.00095 | NA | |
142 | hsa-miR-15a-5p | LATS1 | -0.14 | 0.05362 | -0.01 | 0.91616 | MirTarget; miRNATAP | -0.24 | 0.00017 | NA | |
143 | hsa-miR-15a-5p | LCOR | -0.14 | 0.05362 | 0.13 | 0.26488 | miRNATAP | -0.25 | 0.00246 | NA | |
144 | hsa-miR-15a-5p | LCORL | -0.14 | 0.05362 | -0.06 | 0.23282 | MirTarget; miRNATAP | -0.11 | 0.00122 | NA | |
145 | hsa-miR-15a-5p | LDOC1L | -0.14 | 0.05362 | 0.18 | 0.00268 | mirMAP | -0.14 | 3.0E-5 | NA | |
146 | hsa-miR-15a-5p | LMX1B | -0.14 | 0.05362 | -0 | 0.99575 | mirMAP | -0.31 | 0.01895 | NA | |
147 | hsa-miR-15a-5p | LRIG1 | -0.14 | 0.05362 | 0.39 | 3.0E-5 | MirTarget | -0.4 | 0 | NA | |
148 | hsa-miR-15a-5p | LRIG2 | -0.14 | 0.05362 | -0.05 | 0.3941 | MirTarget | -0.12 | 0.00538 | NA | |
149 | hsa-miR-15a-5p | LRP1B | -0.14 | 0.05362 | 0.61 | 0 | MirTarget; miRNATAP | -0.43 | 0 | NA | |
150 | hsa-miR-15a-5p | LRP6 | -0.14 | 0.05362 | 0.06 | 0.30332 | miRNATAP | -0.11 | 0.00298 | NA |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | NEUROGENESIS | 65 | 1402 | 1.789e-14 | 8.326e-11 |
2 | REGULATION OF CELL DIFFERENTIATION | 60 | 1492 | 8.223e-11 | 1.913e-07 |
3 | REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT | 62 | 1672 | 9.815e-10 | 1.522e-06 |
4 | NEURON DIFFERENTIATION | 41 | 874 | 1.575e-09 | 1.833e-06 |
5 | REGULATION OF NERVOUS SYSTEM DEVELOPMENT | 37 | 750 | 2.785e-09 | 2.592e-06 |
6 | REGULATION OF CELL DEVELOPMENT | 39 | 836 | 4.781e-09 | 3.708e-06 |
7 | ORGAN MORPHOGENESIS | 39 | 841 | 5.637e-09 | 3.747e-06 |
8 | CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 28 | 513 | 3.254e-08 | 1.893e-05 |
9 | POSITIVE REGULATION OF DEVELOPMENTAL PROCESS | 45 | 1142 | 4.817e-08 | 2.246e-05 |
10 | CELL DEVELOPMENT | 52 | 1426 | 4.827e-08 | 2.246e-05 |
11 | POSITIVE REGULATION OF CELL DIFFERENTIATION | 36 | 823 | 9.85e-08 | 4.166e-05 |
12 | PROTEIN PHOSPHORYLATION | 39 | 944 | 1.238e-07 | 4.799e-05 |
13 | REGULATION OF NEURON DIFFERENTIATION | 28 | 554 | 1.613e-07 | 5.666e-05 |
14 | DEVELOPMENTAL GROWTH | 21 | 333 | 1.705e-07 | 5.666e-05 |
15 | REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 21 | 337 | 2.08e-07 | 6.453e-05 |
16 | HEART DEVELOPMENT | 25 | 466 | 2.522e-07 | 7.335e-05 |
17 | CELLULAR COMPONENT MORPHOGENESIS | 37 | 900 | 3.022e-07 | 8.271e-05 |
18 | CENTRAL NERVOUS SYSTEM DEVELOPMENT | 36 | 872 | 4.002e-07 | 0.0001035 |
19 | INTRACELLULAR SIGNAL TRANSDUCTION | 53 | 1572 | 4.294e-07 | 0.0001051 |
20 | HEART MORPHOGENESIS | 16 | 212 | 4.856e-07 | 0.000113 |
21 | REGULATION OF CELL MORPHOGENESIS | 27 | 552 | 5.144e-07 | 0.000114 |
22 | SOMITE DEVELOPMENT | 10 | 78 | 5.917e-07 | 0.0001251 |
23 | REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS | 39 | 1021 | 8.989e-07 | 0.0001743 |
24 | CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION | 21 | 368 | 8.796e-07 | 0.0001743 |
25 | POSITIVE REGULATION OF CELL COMMUNICATION | 51 | 1532 | 1.07e-06 | 0.0001991 |
26 | POSITIVE REGULATION OF CELL DEVELOPMENT | 24 | 472 | 1.145e-06 | 0.000205 |
27 | NEURON DEVELOPMENT | 30 | 687 | 1.269e-06 | 0.0002109 |
28 | REGULATION OF NEURON PROJECTION DEVELOPMENT | 22 | 408 | 1.239e-06 | 0.0002109 |
29 | REGULATION OF DEVELOPMENTAL GROWTH | 18 | 289 | 1.569e-06 | 0.0002517 |
30 | TISSUE DEVELOPMENT | 50 | 1518 | 1.881e-06 | 0.0002823 |
31 | REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 56 | 1784 | 1.854e-06 | 0.0002823 |
32 | EMBRYO DEVELOPMENT | 35 | 894 | 1.97e-06 | 0.0002864 |
33 | POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS | 47 | 1395 | 2.169e-06 | 0.0003058 |
34 | SYNAPTIC SIGNALING | 22 | 424 | 2.328e-06 | 0.0003186 |
35 | UROGENITAL SYSTEM DEVELOPMENT | 18 | 299 | 2.542e-06 | 0.0003277 |
36 | CARDIOVASCULAR SYSTEM DEVELOPMENT | 32 | 788 | 2.606e-06 | 0.0003277 |
37 | CIRCULATORY SYSTEM DEVELOPMENT | 32 | 788 | 2.606e-06 | 0.0003277 |
38 | MESENCHYME DEVELOPMENT | 14 | 190 | 3.354e-06 | 0.0004001 |
39 | STEM CELL DIFFERENTIATION | 14 | 190 | 3.354e-06 | 0.0004001 |
40 | POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT | 22 | 437 | 3.792e-06 | 0.0004411 |
41 | NEURON PROJECTION DEVELOPMENT | 25 | 545 | 4.302e-06 | 0.0004882 |
42 | GROWTH | 21 | 410 | 4.843e-06 | 0.0005365 |
43 | CELL FATE COMMITMENT | 15 | 227 | 5.745e-06 | 0.0006216 |
44 | EPITHELIUM DEVELOPMENT | 35 | 945 | 6.688e-06 | 0.0006996 |
45 | POSITIVE REGULATION OF LOCOMOTION | 21 | 420 | 7.012e-06 | 0.0006996 |
46 | KIDNEY EPITHELIUM DEVELOPMENT | 11 | 125 | 7.067e-06 | 0.0006996 |
47 | HEAD DEVELOPMENT | 29 | 709 | 6.844e-06 | 0.0006996 |
48 | TUBE MORPHOGENESIS | 18 | 323 | 7.435e-06 | 0.0007207 |
49 | TISSUE MORPHOGENESIS | 24 | 533 | 9.156e-06 | 0.0008695 |
50 | REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 51 | 1656 | 9.794e-06 | 0.0009114 |
51 | ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY | 28 | 689 | 1.117e-05 | 0.001019 |
52 | MORPHOGENESIS OF AN EPITHELIUM | 20 | 400 | 1.161e-05 | 0.001039 |
53 | NEURON PROJECTION MORPHOGENESIS | 20 | 402 | 1.249e-05 | 0.001096 |
54 | PHOSPHORYLATION | 41 | 1228 | 1.286e-05 | 0.001108 |
55 | MESENCHYMAL CELL DIFFERENTIATION | 11 | 134 | 1.374e-05 | 0.001163 |
56 | TUBE DEVELOPMENT | 24 | 552 | 1.629e-05 | 0.001354 |
57 | MESONEPHROS DEVELOPMENT | 9 | 90 | 1.734e-05 | 0.001416 |
58 | REGULATION OF CELL PROJECTION ORGANIZATION | 24 | 558 | 1.942e-05 | 0.001558 |
59 | ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS | 34 | 957 | 2.16e-05 | 0.001693 |
60 | REGULATION OF EPITHELIAL CELL PROLIFERATION | 16 | 285 | 2.184e-05 | 0.001693 |
61 | SKELETAL SYSTEM DEVELOPMENT | 21 | 455 | 2.329e-05 | 0.001749 |
62 | REGULATION OF PROTEIN MODIFICATION PROCESS | 51 | 1710 | 2.331e-05 | 0.001749 |
63 | REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS | 14 | 229 | 2.808e-05 | 0.002056 |
64 | NEGATIVE REGULATION OF CELL DIFFERENTIATION | 25 | 609 | 2.828e-05 | 0.002056 |
65 | REGULATION OF DENDRITE MORPHOGENESIS | 8 | 74 | 2.889e-05 | 0.002068 |
66 | INNERVATION | 5 | 23 | 3.082e-05 | 0.002173 |
67 | REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY | 14 | 232 | 3.241e-05 | 0.002251 |
68 | POSITIVE REGULATION OF MOLECULAR FUNCTION | 52 | 1791 | 3.928e-05 | 0.002649 |
69 | CELL PROJECTION ORGANIZATION | 32 | 902 | 3.922e-05 | 0.002649 |
70 | RESPONSE TO GROWTH FACTOR | 21 | 475 | 4.357e-05 | 0.002896 |
71 | EMBRYONIC PATTERN SPECIFICATION | 7 | 58 | 4.477e-05 | 0.002934 |
72 | EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING | 23 | 554 | 4.997e-05 | 0.00323 |
73 | CELLULAR RESPONSE TO ENDOGENOUS STIMULUS | 34 | 1008 | 6.095e-05 | 0.003849 |
74 | REGULATION OF CELL PROLIFERATION | 45 | 1496 | 6.122e-05 | 0.003849 |
75 | PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS | 55 | 1977 | 7.278e-05 | 0.004515 |
76 | PROTEIN DEPHOSPHORYLATION | 12 | 190 | 7.645e-05 | 0.004681 |
77 | REGULATION OF CELLULAR COMPONENT MOVEMENT | 28 | 771 | 8.153e-05 | 0.004864 |
78 | CELL GROWTH | 10 | 135 | 8.11e-05 | 0.004864 |
79 | POSITIVE REGULATION OF BIOSYNTHETIC PROCESS | 51 | 1805 | 9.419e-05 | 0.005478 |
80 | EMBRYONIC MORPHOGENESIS | 22 | 539 | 9.322e-05 | 0.005478 |
81 | GLAND DEVELOPMENT | 18 | 395 | 0.0001047 | 0.006014 |
82 | NEURON CELL CELL ADHESION | 4 | 16 | 0.0001119 | 0.006351 |
83 | REGULATION OF CELL MATRIX ADHESION | 8 | 90 | 0.0001184 | 0.006636 |
84 | NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT | 14 | 262 | 0.0001199 | 0.006643 |
85 | PRESYNAPTIC PROCESS INVOLVED IN SYNAPTIC TRANSMISSION | 9 | 116 | 0.0001289 | 0.007057 |
86 | RESPONSE TO TRANSFORMING GROWTH FACTOR BETA | 10 | 144 | 0.0001388 | 0.007424 |
87 | NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 9 | 117 | 0.0001377 | 0.007424 |
88 | SIGNAL RELEASE | 11 | 173 | 0.0001427 | 0.007545 |
89 | NEGATIVE REGULATION OF CELL DEVELOPMENT | 15 | 303 | 0.0001608 | 0.008409 |
90 | REGULATION OF DENDRITE DEVELOPMENT | 9 | 120 | 0.000167 | 0.008633 |
91 | CELL CELL SIGNALING | 27 | 767 | 0.0001815 | 0.009268 |
92 | REGULATION OF OSSIFICATION | 11 | 178 | 0.0001833 | 0.009268 |
93 | REGULATION OF PHOSPHORUS METABOLIC PROCESS | 46 | 1618 | 0.0001879 | 0.009402 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY | 8 | 64 | 9.784e-06 | 0.009089 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | NEURON PART | 46 | 1265 | 3.462e-07 | 0.0001011 |
2 | SYNAPSE | 33 | 754 | 3.447e-07 | 0.0001011 |
3 | SOMATODENDRITIC COMPARTMENT | 29 | 650 | 1.255e-06 | 0.0002443 |
4 | NEURON PROJECTION | 35 | 942 | 6.243e-06 | 0.0009115 |
5 | SYNAPSE PART | 25 | 610 | 2.906e-05 | 0.003394 |
Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|---|
1 | MAPK_signaling_pathway_hsa04010 | 17 | 295 | 8.613e-06 | 0.0004479 | |
2 | Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 | 11 | 139 | 1.942e-05 | 0.0005048 | |
3 | mTOR_signaling_pathway_hsa04150 | 11 | 151 | 4.191e-05 | 0.0007265 | |
4 | PI3K_Akt_signaling_pathway_hsa04151 | 16 | 352 | 0.0002588 | 0.003365 | |
5 | TNF_signaling_pathway_hsa04668 | 7 | 108 | 0.002065 | 0.01954 | |
6 | Rap1_signaling_pathway_hsa04015 | 10 | 206 | 0.002255 | 0.01954 | |
7 | Oocyte_meiosis_hsa04114 | 7 | 124 | 0.004466 | 0.03318 | |
8 | Ras_signaling_pathway_hsa04014 | 10 | 232 | 0.005238 | 0.03405 | |
9 | FoxO_signaling_pathway_hsa04068 | 7 | 132 | 0.006261 | 0.03618 | |
10 | Hedgehog_signaling_pathway_hsa04340 | 4 | 47 | 0.007353 | 0.03824 | |
11 | Wnt_signaling_pathway_hsa04310 | 7 | 146 | 0.01062 | 0.05022 | |
12 | Hippo_signaling_pathway_multiple_species_hsa04392 | 3 | 29 | 0.01175 | 0.0509 | |
13 | ErbB_signaling_pathway_hsa04012 | 5 | 85 | 0.01314 | 0.05176 | |
14 | Hippo_signaling_pathway_hsa04390 | 7 | 154 | 0.01393 | 0.05176 | |
15 | AMPK_signaling_pathway_hsa04152 | 6 | 121 | 0.01503 | 0.05211 | |
16 | VEGF_signaling_pathway_hsa04370 | 4 | 59 | 0.0161 | 0.05234 | |
17 | Focal_adhesion_hsa04510 | 8 | 199 | 0.0175 | 0.05352 | |
18 | Regulation_of_actin_cytoskeleton_hsa04810 | 8 | 208 | 0.02214 | 0.06397 | |
19 | Phosphatidylinositol_signaling_system_hsa04070 | 5 | 99 | 0.02384 | 0.06439 | |
20 | HIF_1_signaling_pathway_hsa04066 | 5 | 100 | 0.02476 | 0.06439 | |
21 | Sphingolipid_signaling_pathway_hsa04071 | 5 | 118 | 0.04554 | 0.1127 | |
22 | Cellular_senescence_hsa04218 | 6 | 160 | 0.04923 | 0.1127 | |
23 | TGF_beta_signaling_pathway_hsa04350 | 4 | 84 | 0.04984 | 0.1127 | |
24 | Autophagy_animal_hsa04140 | 5 | 128 | 0.06051 | 0.1311 | |
25 | Apoptosis_hsa04210 | 5 | 138 | 0.07796 | 0.1614 | |
26 | Calcium_signaling_pathway_hsa04020 | 6 | 182 | 0.08071 | 0.1614 | |
27 | Phospholipase_D_signaling_pathway_hsa04072 | 5 | 146 | 0.09367 | 0.1804 | |
28 | Apoptosis_multiple_species_hsa04215 | 2 | 33 | 0.1021 | 0.1897 | |
29 | cAMP_signaling_pathway_hsa04024 | 6 | 198 | 0.1093 | 0.196 | |
30 | Jak_STAT_signaling_pathway_hsa04630 | 5 | 162 | 0.1295 | 0.2213 | |
31 | cGMP_PKG_signaling_pathway_hsa04022 | 5 | 163 | 0.1319 | 0.2213 | |
32 | Peroxisome_hsa04146 | 3 | 83 | 0.1566 | 0.2545 | |
33 | Gap_junction_hsa04540 | 3 | 88 | 0.1767 | 0.2784 | |
34 | Notch_signaling_pathway_hsa04330 | 2 | 48 | 0.1867 | 0.2816 | |
35 | Apelin_signaling_pathway_hsa04371 | 4 | 137 | 0.1895 | 0.2816 | |
36 | Adherens_junction_hsa04520 | 2 | 72 | 0.3324 | 0.4801 | |
37 | Endocytosis_hsa04144 | 5 | 244 | 0.3739 | 0.5254 | |
38 | Cytokine_cytokine_receptor_interaction_hsa04060 | 5 | 270 | 0.458 | 0.6199 | |
39 | NF_kappa_B_signaling_pathway_hsa04064 | 2 | 95 | 0.4649 | 0.6199 | |
40 | Tight_junction_hsa04530 | 3 | 170 | 0.5321 | 0.6917 | |
41 | Cell_cycle_hsa04110 | 2 | 124 | 0.6078 | 0.7709 | |
42 | Neuroactive_ligand_receptor_interaction_hsa04080 | 4 | 278 | 0.6738 | 0.8178 | |
43 | Cell_adhesion_molecules_.CAMs._hsa04514 | 2 | 145 | 0.692 | 0.8178 | |
44 | Necroptosis_hsa04217 | 2 | 164 | 0.7548 | 0.8532 |