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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-15a-5p ABL2 -0.14 0.05362 0.12 0.01311 MirTarget; miRNATAP -0.17 0 NA
2 hsa-miR-15a-5p ACOX1 -0.14 0.05362 0.07 0.18823 miRNATAP -0.13 0 NA
3 hsa-miR-15a-5p ACVR2B -0.14 0.05362 0.26 0.0002 miRNATAP -0.36 0 NA
4 hsa-miR-15a-5p ADAMTS5 -0.14 0.05362 0.25 0.0171 miRNATAP -0.44 0 NA
5 hsa-miR-15a-5p ADAMTSL3 -0.14 0.05362 0.38 0.00318 MirTarget -0.21 0.02037 NA
6 hsa-miR-15a-5p ADCY5 -0.14 0.05362 0.4 1.0E-5 MirTarget; miRNATAP -0.13 0.03856 NA
7 hsa-miR-15a-5p AHCYL2 -0.14 0.05362 0.26 0.00064 miRNATAP -0.14 0.00169 NA
8 hsa-miR-15a-5p AKT3 -0.14 0.05362 0.24 0.00086 miRNAWalker2 validate; miRTarBase; miRNATAP -0.17 0.0001 NA
9 hsa-miR-15a-5p AMOTL1 -0.14 0.05362 0.15 0.02214 MirTarget; miRNATAP -0.2 0 NA
10 hsa-miR-15a-5p ANAPC16 -0.14 0.05362 0.17 0.00053 miRNAWalker2 validate -0.11 3.0E-5 NA
11 hsa-miR-15a-5p ANKRD13B -0.14 0.05362 0.09 0.14467 miRNATAP -0.19 0 NA
12 hsa-miR-15a-5p ANKRD46 -0.14 0.05362 0.33 0 MirTarget -0.21 0 NA
13 hsa-miR-15a-5p ANO3 -0.14 0.05362 0.68 6.0E-5 MirTarget; miRNATAP -0.35 0.00473 NA
14 hsa-miR-15a-5p AQP11 -0.14 0.05362 0.06 0.16264 MirTarget -0.14 0 NA
15 hsa-miR-15a-5p ARHGAP12 -0.14 0.05362 0.23 0.00014 miRNATAP -0.29 0 NA
16 hsa-miR-15a-5p ARHGAP32 -0.14 0.05362 0.39 0 MirTarget -0.21 0 NA
17 hsa-miR-15a-5p ARHGAP5 -0.14 0.05362 0.27 2.0E-5 MirTarget; miRNATAP -0.16 1.0E-5 NA
18 hsa-miR-15a-5p ARHGEF7 -0.14 0.05362 0.2 0.00262 mirMAP -0.12 0.00071 NA
19 hsa-miR-15a-5p ARHGEF9 -0.14 0.05362 0.26 9.0E-5 miRNATAP -0.11 0.0068 NA
20 hsa-miR-15a-5p ARL3 -0.14 0.05362 0.42 0 MirTarget -0.29 0 NA
21 hsa-miR-15a-5p ARNT2 -0.14 0.05362 0.28 3.0E-5 mirMAP -0.13 0.00012 NA
22 hsa-miR-15a-5p ASB1 -0.14 0.05362 0.22 0.00013 MirTarget; miRNATAP -0.12 0.00094 NA
23 hsa-miR-15a-5p ASH1L -0.14 0.05362 0.19 0.00262 MirTarget; miRNATAP -0.16 0 NA
24 hsa-miR-15a-5p ASTN1 -0.14 0.05362 0.2 0.0215 MirTarget -0.14 0.00652 NA
25 hsa-miR-15a-5p ATF2 -0.14 0.05362 0.07 0.33393 miRNAWalker2 validate -0.14 0.00412 NA
26 hsa-miR-15a-5p ATP2B2 -0.14 0.05362 0.46 1.0E-5 MirTarget; miRNATAP -0.17 0.02279 NA
27 hsa-miR-15a-5p ATP8A1 -0.14 0.05362 0.61 0 MirTarget -0.18 0.00441 NA
28 hsa-miR-15a-5p ATXN7L2 -0.14 0.05362 0.01 0.89891 MirTarget; miRNATAP -0.11 0.02572 NA
29 hsa-miR-15a-5p ATXN7L3B -0.14 0.05362 0.18 0.00137 MirTarget -0.1 0.00019 NA
30 hsa-miR-15a-5p AVL9 -0.14 0.05362 0.01 0.87129 MirTarget; miRNATAP -0.16 0.00148 NA
31 hsa-miR-15a-5p AXIN2 -0.14 0.05362 0.25 5.0E-5 MirTarget; miRNATAP -0.22 0 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy
32 hsa-miR-15a-5p BACH2 -0.14 0.05362 -0.06 0.32181 MirTarget; miRNATAP -0.12 0.00617 NA
33 hsa-miR-15a-5p BAG4 -0.14 0.05362 0.14 0.09377 MirTarget -0.16 0.00785 NA
34 hsa-miR-15a-5p BCL11B -0.14 0.05362 0.52 0 MirTarget -0.24 0.00194 NA
35 hsa-miR-15a-5p BCL2 -0.14 0.05362 0.19 0.00385 miRNAWalker2 validate; miRTarBase -0.15 0.00052 25594541; 26915294; 18931683; 25623762; 22335947 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05
36 hsa-miR-15a-5p BPTF -0.14 0.05362 0.02 0.68617 miRNATAP -0.12 0.00015 NA
37 hsa-miR-15a-5p BRD3 -0.14 0.05362 0.08 0.14277 mirMAP -0.21 0 NA
38 hsa-miR-15a-5p BRPF3 -0.14 0.05362 0.12 0.05233 miRNATAP -0.14 0.00029 NA
39 hsa-miR-15a-5p BRSK2 -0.14 0.05362 0.44 0 mirMAP -0.3 1.0E-5 NA
40 hsa-miR-15a-5p BRWD3 -0.14 0.05362 -0.07 0.49067 MirTarget -0.22 0.00106 NA
41 hsa-miR-15a-5p BTAF1 -0.14 0.05362 0.15 0.02765 MirTarget -0.2 0 NA
42 hsa-miR-15a-5p BTRC -0.14 0.05362 0.32 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.2 0 NA
43 hsa-miR-15a-5p C1orf21 -0.14 0.05362 0.14 0.0272 mirMAP; miRNATAP -0.1 0.00612 NA
44 hsa-miR-15a-5p C2orf72 -0.14 0.05362 0.16 0.02282 miRNATAP -0.13 0.00506 NA
45 hsa-miR-15a-5p CACNA1E -0.14 0.05362 0.57 0.0001 MirTarget -0.4 0.00012 NA
46 hsa-miR-15a-5p CALN1 -0.14 0.05362 1.22 0 mirMAP -0.7 0 NA
47 hsa-miR-15a-5p CAMSAP1 -0.14 0.05362 0.07 0.16428 MirTarget; miRNATAP -0.13 0 NA
48 hsa-miR-15a-5p CASK -0.14 0.05362 0.16 0.01486 MirTarget; miRNATAP -0.23 0 NA
49 hsa-miR-15a-5p CASKIN1 -0.14 0.05362 0.74 0 miRNATAP -0.45 0 NA
50 hsa-miR-15a-5p CASP9 -0.14 0.05362 0.19 0.00861 mirMAP -0.24 0 NA
51 hsa-miR-15a-5p CASZ1 -0.14 0.05362 -0.06 0.59914 MirTarget -0.25 0.00172 NA
52 hsa-miR-15a-5p CBFA2T3 -0.14 0.05362 0.38 1.0E-5 MirTarget; miRNATAP -0.22 0.00018 NA
53 hsa-miR-15a-5p CCDC6 -0.14 0.05362 0.18 0.00033 MirTarget; miRNATAP -0.11 3.0E-5 NA
54 hsa-miR-15a-5p CCDC85C -0.14 0.05362 0.36 0 MirTarget -0.26 0 NA
55 hsa-miR-15a-5p CCNJ -0.14 0.05362 -0.04 0.44486 miRNATAP -0.12 0.00032 NA
56 hsa-miR-15a-5p CCT6B -0.14 0.05362 0.27 1.0E-5 miRNAWalker2 validate -0.15 0.00081 NA
57 hsa-miR-15a-5p CDC14B -0.14 0.05362 0 0.9326 miRNAWalker2 validate; MirTarget -0.11 6.0E-5 NA
58 hsa-miR-15a-5p CDC37L1 -0.14 0.05362 0.15 0.00032 MirTarget; miRNATAP -0.11 5.0E-5 NA
59 hsa-miR-15a-5p CDK5R1 -0.14 0.05362 0.39 0.00013 MirTarget; miRNATAP -0.37 0 NA
60 hsa-miR-15a-5p CDS2 -0.14 0.05362 0.13 0.01227 mirMAP; miRNATAP -0.14 0 NA
61 hsa-miR-15a-5p CECR6 -0.14 0.05362 0.27 0.00061 MirTarget; miRNATAP -0.27 0 NA
62 hsa-miR-15a-5p CEP350 -0.14 0.05362 0.14 0.01879 miRNATAP -0.13 7.0E-5 NA
63 hsa-miR-15a-5p CHD2 -0.14 0.05362 0.07 0.2131 MirTarget -0.11 1.0E-5 NA
64 hsa-miR-15a-5p CHD5 -0.14 0.05362 0.9 0 miRNATAP -0.33 0.01493 NA
65 hsa-miR-15a-5p CHD9 -0.14 0.05362 0.05 0.43798 miRNATAP -0.14 0.00033 NA
66 hsa-miR-15a-5p CHUK -0.14 0.05362 0.08 0.04445 miRNAWalker2 validate; miRTarBase; MirTarget -0.11 0 NA
67 hsa-miR-15a-5p CNKSR2 -0.14 0.05362 0.47 0.0001 miRNATAP -0.21 0.01597 NA
68 hsa-miR-15a-5p COX15 -0.14 0.05362 0.18 0.00014 MirTarget -0.17 0 NA
69 hsa-miR-15a-5p CPEB3 -0.14 0.05362 0.56 0 MirTarget; miRNATAP -0.32 0 NA
70 hsa-miR-15a-5p CPSF7 -0.14 0.05362 0.07 0.13095 MirTarget; miRNATAP -0.12 0 NA
71 hsa-miR-15a-5p CRKL -0.14 0.05362 0.09 0.08948 miRTarBase; MirTarget; miRNATAP -0.13 0 NA
72 hsa-miR-15a-5p CSF1 -0.14 0.05362 0.12 0.20838 miRNATAP -0.18 0.00668 NA
73 hsa-miR-15a-5p CUL2 -0.14 0.05362 0.15 0.00071 MirTarget; miRNATAP -0.1 3.0E-5 NA
74 hsa-miR-15a-5p CX3CL1 -0.14 0.05362 0.2 0.0062 miRNATAP -0.18 7.0E-5 NA
75 hsa-miR-15a-5p CYS1 -0.14 0.05362 0.74 0 mirMAP -0.25 0.00101 NA
76 hsa-miR-15a-5p DCAF5 -0.14 0.05362 0.16 0.00087 MirTarget; miRNATAP -0.16 0 NA
77 hsa-miR-15a-5p DCAF7 -0.14 0.05362 -0 0.95508 miRNATAP -0.15 0 NA
78 hsa-miR-15a-5p DCLK1 -0.14 0.05362 0.49 0 miRNATAP -0.17 0.01602 NA
79 hsa-miR-15a-5p DCX -0.14 0.05362 0.35 0.02122 mirMAP -0.58 0 NA
80 hsa-miR-15a-5p DENND1B -0.14 0.05362 -0.03 0.68777 miRNATAP -0.15 0.00126 NA
81 hsa-miR-15a-5p DGCR2 -0.14 0.05362 0.25 0.00027 mirMAP -0.18 0 NA
82 hsa-miR-15a-5p DLL1 -0.14 0.05362 0.29 0.00828 miRNATAP -0.59 0 NA
83 hsa-miR-15a-5p EDA -0.14 0.05362 0.33 0 MirTarget; miRNATAP -0.11 0.03005 NA
84 hsa-miR-15a-5p EIF3A -0.14 0.05362 0.08 0.18481 MirTarget; miRNATAP -0.12 4.0E-5 NA
85 hsa-miR-15a-5p EIF4B -0.14 0.05362 0.15 0.02719 miRNATAP -0.16 1.0E-5 NA
86 hsa-miR-15a-5p ELMO2 -0.14 0.05362 0.12 0.02299 miRNATAP -0.12 0 NA
87 hsa-miR-15a-5p ENAH -0.14 0.05362 -0.04 0.60098 MirTarget; miRNATAP -0.19 0 NA
88 hsa-miR-15a-5p EPB41L5 -0.14 0.05362 0.02 0.70936 MirTarget -0.1 0.00082 NA
89 hsa-miR-15a-5p ERC2 -0.14 0.05362 0.5 0 MirTarget; miRNATAP -0.32 2.0E-5 NA
90 hsa-miR-15a-5p ERCC6 -0.14 0.05362 0.16 0.00387 MirTarget -0.18 0 NA
91 hsa-miR-15a-5p EYA1 -0.14 0.05362 0.87 0 miRNATAP -0.86 0 NA
92 hsa-miR-15a-5p FAM120C -0.14 0.05362 0.14 0.00494 MirTarget; miRNATAP -0.16 0 NA
93 hsa-miR-15a-5p FAM60A -0.14 0.05362 -0.26 0.00567 miRNATAP -0.15 0.0194 NA
94 hsa-miR-15a-5p FAM69A -0.14 0.05362 0.43 0 miRNAWalker2 validate -0.16 0.00319 NA
95 hsa-miR-15a-5p FAM84B -0.14 0.05362 0.24 0.02718 MirTarget -0.38 0 NA
96 hsa-miR-15a-5p FASN -0.14 0.05362 0.25 0.00074 miRNAWalker2 validate; MirTarget -0.18 1.0E-5 27713175 Both miR-15a and miR-16-1 contributes to inhibiting FASN expression and breast cancer cell proliferation; In conclusion we demonstrated that FASN expression is primarily downregulated by miR-15a and miR-16-1 in mammary cells and FASN is one of the major targets of these two tumor suppressive microRNAs
97 hsa-miR-15a-5p FAT3 -0.14 0.05362 0.36 0.0001 MirTarget; miRNATAP -0.33 0 NA
98 hsa-miR-15a-5p FAT4 -0.14 0.05362 0.1 0.30301 MirTarget -0.17 0.00831 NA
99 hsa-miR-15a-5p FBXO21 -0.14 0.05362 0.07 0.22868 MirTarget; miRNATAP -0.18 0 NA
100 hsa-miR-15a-5p FCHSD2 -0.14 0.05362 0.25 0.00061 miRNATAP -0.33 0 NA
101 hsa-miR-15a-5p FGF2 -0.14 0.05362 0.31 1.0E-5 MirTarget; miRNATAP -0.21 0 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration
102 hsa-miR-15a-5p FGF9 -0.14 0.05362 0.6 5.0E-5 miRNATAP -0.28 0.00935 NA
103 hsa-miR-15a-5p FRMPD1 -0.14 0.05362 0.48 1.0E-5 MirTarget -0.5 0 NA
104 hsa-miR-15a-5p FRY -0.14 0.05362 0.41 0 miRNATAP -0.3 0 NA
105 hsa-miR-15a-5p FSD1 -0.14 0.05362 0.24 0.00734 MirTarget; miRNATAP -0.22 0.00027 NA
106 hsa-miR-15a-5p GABRA1 -0.14 0.05362 1.01 0.00014 miRNATAP -0.41 0.03179 NA
107 hsa-miR-15a-5p GALNT13 -0.14 0.05362 0.78 0 MirTarget -0.82 0 NA
108 hsa-miR-15a-5p GHR -0.14 0.05362 0.17 0.06404 MirTarget; miRNATAP -0.28 1.0E-5 NA
109 hsa-miR-15a-5p GLUD1 -0.14 0.05362 0.6 0 MirTarget; miRNATAP -0.47 0 NA
110 hsa-miR-15a-5p GNAL -0.14 0.05362 0.84 0 miRNATAP -0.64 0 NA
111 hsa-miR-15a-5p GNAO1 -0.14 0.05362 0.4 0 mirMAP -0.19 0.00011 NA
112 hsa-miR-15a-5p GORASP1 -0.14 0.05362 0.21 5.0E-5 MirTarget -0.11 8.0E-5 NA
113 hsa-miR-15a-5p GPR153 -0.14 0.05362 0.22 0.04826 miRNATAP -0.29 0.00016 NA
114 hsa-miR-15a-5p GPRIN2 -0.14 0.05362 0.73 0 mirMAP -0.21 0.03819 NA
115 hsa-miR-15a-5p GRAMD3 -0.14 0.05362 0.36 2.0E-5 MirTarget -0.19 0.00024 NA
116 hsa-miR-15a-5p GTPBP1 -0.14 0.05362 0.08 0.13085 MirTarget -0.13 0 NA
117 hsa-miR-15a-5p HAS2 -0.14 0.05362 -0.51 0.00062 MirTarget -0.22 0.04279 NA
118 hsa-miR-15a-5p HECTD1 -0.14 0.05362 0.16 0.00456 miRNATAP -0.11 6.0E-5 NA
119 hsa-miR-15a-5p HHIPL1 -0.14 0.05362 0.36 0 mirMAP -0.12 0.00688 NA
120 hsa-miR-15a-5p HIPK2 -0.14 0.05362 0.36 1.0E-5 miRNATAP -0.26 0 NA
121 hsa-miR-15a-5p HIRA -0.14 0.05362 0.13 0.00442 MirTarget; miRNATAP -0.13 0 NA
122 hsa-miR-15a-5p HNRNPA1 -0.14 0.05362 0.07 0.27756 miRNATAP -0.12 0.00032 NA
123 hsa-miR-15a-5p HPCAL4 -0.14 0.05362 0.98 0 MirTarget -0.38 0.00154 NA
124 hsa-miR-15a-5p HPSE2 -0.14 0.05362 2.23 0 MirTarget -1.45 0 NA
125 hsa-miR-15a-5p HSDL2 -0.14 0.05362 0.24 8.0E-5 miRNAWalker2 validate -0.12 0.00059 NA
126 hsa-miR-15a-5p HTR2A -0.14 0.05362 1.17 0 MirTarget -0.61 0 NA
127 hsa-miR-15a-5p IGF1R -0.14 0.05362 0.14 0.0366 miRNATAP -0.22 0 NA
128 hsa-miR-15a-5p IGSF9B -0.14 0.05362 -0.01 0.95586 mirMAP -0.2 0.03701 NA
129 hsa-miR-15a-5p IPO7 -0.14 0.05362 0.07 0.29652 MirTarget; miRNATAP -0.18 0 NA
130 hsa-miR-15a-5p JARID2 -0.14 0.05362 0.14 0.00609 MirTarget; miRNATAP -0.2 0 NA
131 hsa-miR-15a-5p KBTBD4 -0.14 0.05362 0.11 0.03379 miRNATAP -0.11 0.00051 NA
132 hsa-miR-15a-5p KCNA6 -0.14 0.05362 0.19 0.03684 MirTarget -0.14 0.01997 NA
133 hsa-miR-15a-5p KCNC2 -0.14 0.05362 0.7 0.00595 MirTarget; miRNATAP -0.43 0.01992 NA
134 hsa-miR-15a-5p KCNK3 -0.14 0.05362 0.75 1.0E-5 mirMAP -0.56 0 NA
135 hsa-miR-15a-5p KCNQ5 -0.14 0.05362 0.7 0 miRNATAP -0.59 0 NA
136 hsa-miR-15a-5p KIAA1147 -0.14 0.05362 0.35 0 mirMAP -0.17 0 NA
137 hsa-miR-15a-5p KIAA1644 -0.14 0.05362 1.05 0 mirMAP -0.6 1.0E-5 NA
138 hsa-miR-15a-5p KIAA2022 -0.14 0.05362 0.41 0.00032 MirTarget; miRNATAP -0.3 0.00021 NA
139 hsa-miR-15a-5p KIF1A -0.14 0.05362 0.54 0 miRNAWalker2 validate -0.22 2.0E-5 NA
140 hsa-miR-15a-5p KIF1B -0.14 0.05362 0.26 0.00052 miRNATAP -0.23 0 NA
141 hsa-miR-15a-5p KLHDC8B -0.14 0.05362 0.12 0.0252 MirTarget -0.11 0.00095 NA
142 hsa-miR-15a-5p LATS1 -0.14 0.05362 -0.01 0.91616 MirTarget; miRNATAP -0.24 0.00017 NA
143 hsa-miR-15a-5p LCOR -0.14 0.05362 0.13 0.26488 miRNATAP -0.25 0.00246 NA
144 hsa-miR-15a-5p LCORL -0.14 0.05362 -0.06 0.23282 MirTarget; miRNATAP -0.11 0.00122 NA
145 hsa-miR-15a-5p LDOC1L -0.14 0.05362 0.18 0.00268 mirMAP -0.14 3.0E-5 NA
146 hsa-miR-15a-5p LMX1B -0.14 0.05362 -0 0.99575 mirMAP -0.31 0.01895 NA
147 hsa-miR-15a-5p LRIG1 -0.14 0.05362 0.39 3.0E-5 MirTarget -0.4 0 NA
148 hsa-miR-15a-5p LRIG2 -0.14 0.05362 -0.05 0.3941 MirTarget -0.12 0.00538 NA
149 hsa-miR-15a-5p LRP1B -0.14 0.05362 0.61 0 MirTarget; miRNATAP -0.43 0 NA
150 hsa-miR-15a-5p LRP6 -0.14 0.05362 0.06 0.30332 miRNATAP -0.11 0.00298 NA
NumGOOverlapSizeP ValueAdj. P Value
1 NEUROGENESIS 65 1402 1.789e-14 8.326e-11
2 REGULATION OF CELL DIFFERENTIATION 60 1492 8.223e-11 1.913e-07
3 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 62 1672 9.815e-10 1.522e-06
4 NEURON DIFFERENTIATION 41 874 1.575e-09 1.833e-06
5 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 37 750 2.785e-09 2.592e-06
6 REGULATION OF CELL DEVELOPMENT 39 836 4.781e-09 3.708e-06
7 ORGAN MORPHOGENESIS 39 841 5.637e-09 3.747e-06
8 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 28 513 3.254e-08 1.893e-05
9 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 45 1142 4.817e-08 2.246e-05
10 CELL DEVELOPMENT 52 1426 4.827e-08 2.246e-05
11 POSITIVE REGULATION OF CELL DIFFERENTIATION 36 823 9.85e-08 4.166e-05
12 PROTEIN PHOSPHORYLATION 39 944 1.238e-07 4.799e-05
13 REGULATION OF NEURON DIFFERENTIATION 28 554 1.613e-07 5.666e-05
14 DEVELOPMENTAL GROWTH 21 333 1.705e-07 5.666e-05
15 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 21 337 2.08e-07 6.453e-05
16 HEART DEVELOPMENT 25 466 2.522e-07 7.335e-05
17 CELLULAR COMPONENT MORPHOGENESIS 37 900 3.022e-07 8.271e-05
18 CENTRAL NERVOUS SYSTEM DEVELOPMENT 36 872 4.002e-07 0.0001035
19 INTRACELLULAR SIGNAL TRANSDUCTION 53 1572 4.294e-07 0.0001051
20 HEART MORPHOGENESIS 16 212 4.856e-07 0.000113
21 REGULATION OF CELL MORPHOGENESIS 27 552 5.144e-07 0.000114
22 SOMITE DEVELOPMENT 10 78 5.917e-07 0.0001251
23 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 39 1021 8.989e-07 0.0001743
24 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 21 368 8.796e-07 0.0001743
25 POSITIVE REGULATION OF CELL COMMUNICATION 51 1532 1.07e-06 0.0001991
26 POSITIVE REGULATION OF CELL DEVELOPMENT 24 472 1.145e-06 0.000205
27 NEURON DEVELOPMENT 30 687 1.269e-06 0.0002109
28 REGULATION OF NEURON PROJECTION DEVELOPMENT 22 408 1.239e-06 0.0002109
29 REGULATION OF DEVELOPMENTAL GROWTH 18 289 1.569e-06 0.0002517
30 TISSUE DEVELOPMENT 50 1518 1.881e-06 0.0002823
31 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 56 1784 1.854e-06 0.0002823
32 EMBRYO DEVELOPMENT 35 894 1.97e-06 0.0002864
33 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 47 1395 2.169e-06 0.0003058
34 SYNAPTIC SIGNALING 22 424 2.328e-06 0.0003186
35 UROGENITAL SYSTEM DEVELOPMENT 18 299 2.542e-06 0.0003277
36 CARDIOVASCULAR SYSTEM DEVELOPMENT 32 788 2.606e-06 0.0003277
37 CIRCULATORY SYSTEM DEVELOPMENT 32 788 2.606e-06 0.0003277
38 MESENCHYME DEVELOPMENT 14 190 3.354e-06 0.0004001
39 STEM CELL DIFFERENTIATION 14 190 3.354e-06 0.0004001
40 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 22 437 3.792e-06 0.0004411
41 NEURON PROJECTION DEVELOPMENT 25 545 4.302e-06 0.0004882
42 GROWTH 21 410 4.843e-06 0.0005365
43 CELL FATE COMMITMENT 15 227 5.745e-06 0.0006216
44 EPITHELIUM DEVELOPMENT 35 945 6.688e-06 0.0006996
45 POSITIVE REGULATION OF LOCOMOTION 21 420 7.012e-06 0.0006996
46 KIDNEY EPITHELIUM DEVELOPMENT 11 125 7.067e-06 0.0006996
47 HEAD DEVELOPMENT 29 709 6.844e-06 0.0006996
48 TUBE MORPHOGENESIS 18 323 7.435e-06 0.0007207
49 TISSUE MORPHOGENESIS 24 533 9.156e-06 0.0008695
50 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 51 1656 9.794e-06 0.0009114
51 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 28 689 1.117e-05 0.001019
52 MORPHOGENESIS OF AN EPITHELIUM 20 400 1.161e-05 0.001039
53 NEURON PROJECTION MORPHOGENESIS 20 402 1.249e-05 0.001096
54 PHOSPHORYLATION 41 1228 1.286e-05 0.001108
55 MESENCHYMAL CELL DIFFERENTIATION 11 134 1.374e-05 0.001163
56 TUBE DEVELOPMENT 24 552 1.629e-05 0.001354
57 MESONEPHROS DEVELOPMENT 9 90 1.734e-05 0.001416
58 REGULATION OF CELL PROJECTION ORGANIZATION 24 558 1.942e-05 0.001558
59 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 34 957 2.16e-05 0.001693
60 REGULATION OF EPITHELIAL CELL PROLIFERATION 16 285 2.184e-05 0.001693
61 SKELETAL SYSTEM DEVELOPMENT 21 455 2.329e-05 0.001749
62 REGULATION OF PROTEIN MODIFICATION PROCESS 51 1710 2.331e-05 0.001749
63 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 14 229 2.808e-05 0.002056
64 NEGATIVE REGULATION OF CELL DIFFERENTIATION 25 609 2.828e-05 0.002056
65 REGULATION OF DENDRITE MORPHOGENESIS 8 74 2.889e-05 0.002068
66 INNERVATION 5 23 3.082e-05 0.002173
67 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 14 232 3.241e-05 0.002251
68 POSITIVE REGULATION OF MOLECULAR FUNCTION 52 1791 3.928e-05 0.002649
69 CELL PROJECTION ORGANIZATION 32 902 3.922e-05 0.002649
70 RESPONSE TO GROWTH FACTOR 21 475 4.357e-05 0.002896
71 EMBRYONIC PATTERN SPECIFICATION 7 58 4.477e-05 0.002934
72 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 23 554 4.997e-05 0.00323
73 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 34 1008 6.095e-05 0.003849
74 REGULATION OF CELL PROLIFERATION 45 1496 6.122e-05 0.003849
75 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 55 1977 7.278e-05 0.004515
76 PROTEIN DEPHOSPHORYLATION 12 190 7.645e-05 0.004681
77 REGULATION OF CELLULAR COMPONENT MOVEMENT 28 771 8.153e-05 0.004864
78 CELL GROWTH 10 135 8.11e-05 0.004864
79 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 51 1805 9.419e-05 0.005478
80 EMBRYONIC MORPHOGENESIS 22 539 9.322e-05 0.005478
81 GLAND DEVELOPMENT 18 395 0.0001047 0.006014
82 NEURON CELL CELL ADHESION 4 16 0.0001119 0.006351
83 REGULATION OF CELL MATRIX ADHESION 8 90 0.0001184 0.006636
84 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 14 262 0.0001199 0.006643
85 PRESYNAPTIC PROCESS INVOLVED IN SYNAPTIC TRANSMISSION 9 116 0.0001289 0.007057
86 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 10 144 0.0001388 0.007424
87 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 9 117 0.0001377 0.007424
88 SIGNAL RELEASE 11 173 0.0001427 0.007545
89 NEGATIVE REGULATION OF CELL DEVELOPMENT 15 303 0.0001608 0.008409
90 REGULATION OF DENDRITE DEVELOPMENT 9 120 0.000167 0.008633
91 CELL CELL SIGNALING 27 767 0.0001815 0.009268
92 REGULATION OF OSSIFICATION 11 178 0.0001833 0.009268
93 REGULATION OF PHOSPHORUS METABOLIC PROCESS 46 1618 0.0001879 0.009402
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 8 64 9.784e-06 0.009089
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PART 46 1265 3.462e-07 0.0001011
2 SYNAPSE 33 754 3.447e-07 0.0001011
3 SOMATODENDRITIC COMPARTMENT 29 650 1.255e-06 0.0002443
4 NEURON PROJECTION 35 942 6.243e-06 0.0009115
5 SYNAPSE PART 25 610 2.906e-05 0.003394

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 17 295 8.613e-06 0.0004479
2 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 11 139 1.942e-05 0.0005048
3 mTOR_signaling_pathway_hsa04150 11 151 4.191e-05 0.0007265
4 PI3K_Akt_signaling_pathway_hsa04151 16 352 0.0002588 0.003365
5 TNF_signaling_pathway_hsa04668 7 108 0.002065 0.01954
6 Rap1_signaling_pathway_hsa04015 10 206 0.002255 0.01954
7 Oocyte_meiosis_hsa04114 7 124 0.004466 0.03318
8 Ras_signaling_pathway_hsa04014 10 232 0.005238 0.03405
9 FoxO_signaling_pathway_hsa04068 7 132 0.006261 0.03618
10 Hedgehog_signaling_pathway_hsa04340 4 47 0.007353 0.03824
11 Wnt_signaling_pathway_hsa04310 7 146 0.01062 0.05022
12 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.01175 0.0509
13 ErbB_signaling_pathway_hsa04012 5 85 0.01314 0.05176
14 Hippo_signaling_pathway_hsa04390 7 154 0.01393 0.05176
15 AMPK_signaling_pathway_hsa04152 6 121 0.01503 0.05211
16 VEGF_signaling_pathway_hsa04370 4 59 0.0161 0.05234
17 Focal_adhesion_hsa04510 8 199 0.0175 0.05352
18 Regulation_of_actin_cytoskeleton_hsa04810 8 208 0.02214 0.06397
19 Phosphatidylinositol_signaling_system_hsa04070 5 99 0.02384 0.06439
20 HIF_1_signaling_pathway_hsa04066 5 100 0.02476 0.06439
21 Sphingolipid_signaling_pathway_hsa04071 5 118 0.04554 0.1127
22 Cellular_senescence_hsa04218 6 160 0.04923 0.1127
23 TGF_beta_signaling_pathway_hsa04350 4 84 0.04984 0.1127
24 Autophagy_animal_hsa04140 5 128 0.06051 0.1311
25 Apoptosis_hsa04210 5 138 0.07796 0.1614
26 Calcium_signaling_pathway_hsa04020 6 182 0.08071 0.1614
27 Phospholipase_D_signaling_pathway_hsa04072 5 146 0.09367 0.1804
28 Apoptosis_multiple_species_hsa04215 2 33 0.1021 0.1897
29 cAMP_signaling_pathway_hsa04024 6 198 0.1093 0.196
30 Jak_STAT_signaling_pathway_hsa04630 5 162 0.1295 0.2213
31 cGMP_PKG_signaling_pathway_hsa04022 5 163 0.1319 0.2213
32 Peroxisome_hsa04146 3 83 0.1566 0.2545
33 Gap_junction_hsa04540 3 88 0.1767 0.2784
34 Notch_signaling_pathway_hsa04330 2 48 0.1867 0.2816
35 Apelin_signaling_pathway_hsa04371 4 137 0.1895 0.2816
36 Adherens_junction_hsa04520 2 72 0.3324 0.4801
37 Endocytosis_hsa04144 5 244 0.3739 0.5254
38 Cytokine_cytokine_receptor_interaction_hsa04060 5 270 0.458 0.6199
39 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.4649 0.6199
40 Tight_junction_hsa04530 3 170 0.5321 0.6917
41 Cell_cycle_hsa04110 2 124 0.6078 0.7709
42 Neuroactive_ligand_receptor_interaction_hsa04080 4 278 0.6738 0.8178
43 Cell_adhesion_molecules_.CAMs._hsa04514 2 145 0.692 0.8178
44 Necroptosis_hsa04217 2 164 0.7548 0.8532

Quest ID: 04e7f838c57b255c8d865c94f42d379a