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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-16-5p ABHD2 0.75 0 -0.74 0.00059 miRNAWalker2 validate -0.23 0.00021 NA
2 hsa-miR-16-5p ABR 0.75 0 -0.42 0.00325 mirMAP -0.15 0.00023 NA
3 hsa-miR-16-5p ABTB2 0.75 0 0.66 0.00533 MirTarget -0.26 0.00012 NA
4 hsa-miR-16-5p ACSBG1 0.75 0 -2.22 0 MirTarget -0.27 0.00952 NA
5 hsa-miR-16-5p ACTN1 0.75 0 -0.11 0.50739 miRNAWalker2 validate -0.2 3.0E-5 NA
6 hsa-miR-16-5p ADAMTS18 0.75 0 1.34 0.00247 miRNATAP -0.33 0.00801 NA
7 hsa-miR-16-5p ADAMTS5 0.75 0 -0.15 0.63547 miRNATAP -0.23 0.01213 NA
8 hsa-miR-16-5p ADAMTSL3 0.75 0 -3.15 0 MirTarget -0.28 0.00805 NA
9 hsa-miR-193b-3p ADAMTSL3 1.1 0.00082 -3.15 0 MirTarget -0.2 0.00011 NA
10 hsa-miR-16-5p ADCY2 0.75 0 -1.12 0.01473 mirMAP -0.31 0.01775 NA
11 hsa-miR-16-5p ADCY5 0.75 0 -1.41 0.00306 MirTarget; miRNATAP -0.43 0.00144 NA
12 hsa-miR-193b-3p ADCY9 1.1 0.00082 -1.41 0 miRNAWalker2 validate -0.16 0 NA
13 hsa-miR-16-5p AFF4 0.75 0 -0.15 0.22477 MirTarget; miRNATAP -0.11 0.00232 NA
14 hsa-miR-16-5p AHNAK2 0.75 0 1.26 0.00481 miRNAWalker2 validate -0.47 0.00019 NA
15 hsa-miR-16-5p AKAP13 0.75 0 -1.2 0 miRNAWalker2 validate -0.11 0.03621 NA
16 hsa-miR-193b-3p AKAP13 1.1 0.00082 -1.2 0 miRNAWalker2 validate -0.11 1.0E-5 NA
17 hsa-miR-16-5p AKT3 0.75 0 -1.44 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.27 0.0001 NA
18 hsa-miR-193b-3p ALDH1A2 1.1 0.00082 -3.09 0 miRNAWalker2 validate -0.15 0.03662 NA
19 hsa-miR-16-5p AMOTL1 0.75 0 -2.04 0 MirTarget; miRNATAP -0.24 0.00054 NA
20 hsa-miR-16-5p AMPD1 0.75 0 0.11 0.82089 miRNAWalker2 validate -0.32 0.02095 NA
21 hsa-miR-16-5p ANK2 0.75 0 -1.34 2.0E-5 MirTarget; miRNATAP -0.19 0.0313 NA
22 hsa-miR-16-5p ANKS1A 0.75 0 -1.11 0 MirTarget -0.17 1.0E-5 NA
23 hsa-miR-193b-3p APCDD1 1.1 0.00082 -1.24 0 miRNAWalker2 validate -0.15 3.0E-5 NA
24 hsa-miR-16-5p APLN 0.75 0 -2.02 0 MirTarget; miRNATAP -0.2 0.03747 NA
25 hsa-miR-16-5p APP 0.75 0 -0.38 0.01459 miRNAWalker2 validate; miRNATAP -0.19 2.0E-5 NA
26 hsa-miR-16-5p AR 0.75 0 -1.82 6.0E-5 mirMAP; miRNATAP -0.36 0.00512 NA
27 hsa-miR-16-5p ARHGAP20 0.75 0 -1.06 0.00417 MirTarget; miRNATAP -0.29 0.00519 NA
28 hsa-miR-16-5p ARHGAP32 0.75 0 0.45 0.01456 MirTarget -0.2 0.00016 NA
29 hsa-miR-16-5p ARHGEF12 0.75 0 -0.37 0.00513 MirTarget -0.16 1.0E-5 NA
30 hsa-miR-16-5p ARHGEF9 0.75 0 -0.32 0.02245 miRNATAP -0.11 0.00805 NA
31 hsa-miR-16-5p ARL10 0.75 0 -0.26 0.31668 miRNAWalker2 validate -0.24 0.00069 NA
32 hsa-miR-16-5p ARNT2 0.75 0 -1.46 3.0E-5 mirMAP -0.26 0.00826 NA
33 hsa-miR-16-5p ASH1L 0.75 0 0.14 0.3325 miRNAWalker2 validate; MirTarget; miRNATAP -0.12 0.00368 NA
34 hsa-miR-16-5p ASXL2 0.75 0 -0.3 0.12837 miRNAWalker2 validate -0.18 0.00174 NA
35 hsa-miR-16-5p ATF7 0.75 0 -0.29 0.00533 miRNAWalker2 validate -0.11 0.00021 NA
36 hsa-miR-193b-3p ATOH8 1.1 0.00082 -2.72 0 miRNAWalker2 validate -0.25 0.00012 NA
37 hsa-miR-193b-3p ATP1A1 1.1 0.00082 -0.5 0.00344 miRNAWalker2 validate -0.11 0 NA
38 hsa-miR-16-5p ATP7A 0.75 0 -0.09 0.53505 MirTarget -0.12 0.00343 NA
39 hsa-miR-16-5p ATP8A2 0.75 0 -2 0 miRNAWalker2 validate -0.26 0.03432 NA
40 hsa-miR-16-5p ATXN1L 0.75 0 -0.66 0 miRNATAP -0.16 0 NA
41 hsa-miR-16-5p AXIN2 0.75 0 -1.5 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.2 0.01267 NA
42 hsa-miR-16-5p BACE1 0.75 0 -0.8 0 miRNATAP -0.28 0 NA
43 hsa-miR-16-5p BACH2 0.75 0 -0.99 6.0E-5 MirTarget; miRNATAP -0.21 0.00332 NA
44 hsa-miR-16-5p BAMBI 0.75 0 -0.15 0.71189 miRNAWalker2 validate -0.33 0.00433 NA
45 hsa-miR-16-5p BCL2L2 0.75 0 -0.96 0 MirTarget; miRNATAP -0.1 0.00516 NA
46 hsa-miR-193b-3p BHLHE41 1.1 0.00082 -1.4 0 MirTarget -0.14 0.00043 NA
47 hsa-miR-16-5p BMX 0.75 0 -3.65 0 MirTarget; miRNATAP -0.4 0.00175 NA
48 hsa-miR-16-5p BNC2 0.75 0 -1.12 1.0E-5 miRNAWalker2 validate -0.31 1.0E-5 NA
49 hsa-miR-16-5p BRPF3 0.75 0 0.54 0.0003 miRNATAP -0.12 0.00648 NA
50 hsa-miR-16-5p BTBD19 0.75 0 -0.45 0.09192 mirMAP -0.29 0.00011 NA
51 hsa-miR-16-5p BTRC 0.75 0 0.05 0.62283 miRNAWalker2 validate; MirTarget; miRNATAP -0.11 8.0E-5 NA
52 hsa-miR-16-5p C15orf52 0.75 0 -0.97 0.00029 mirMAP -0.19 0.01273 NA
53 hsa-miR-193b-3p C1QC 1.1 0.00082 -1.49 0 MirTarget -0.12 0.0027 NA
54 hsa-miR-193b-3p C1QTNF2 1.1 0.00082 -2.26 0 miRNAWalker2 validate -0.12 0.00164 NA
55 hsa-miR-193b-3p C5 1.1 0.00082 -1.06 0.01163 miRNAWalker2 validate -0.24 3.0E-5 NA
56 hsa-miR-16-5p CABIN1 0.75 0 -0.21 0.11853 miRNAWalker2 validate -0.15 9.0E-5 NA
57 hsa-miR-193b-3p CABLES1 1.1 0.00082 -1.22 0 mirMAP -0.17 0 NA
58 hsa-miR-16-5p CACNA2D1 0.75 0 -1.27 0.00469 miRNAWalker2 validate -0.35 0.00593 NA
59 hsa-miR-16-5p CADM1 0.75 0 -1.98 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.23 0.01532 NA
60 hsa-miR-193b-3p CADM1 1.1 0.00082 -1.98 0 MirTarget -0.28 0 NA
61 hsa-miR-16-5p CARD10 0.75 0 0.34 0.14583 miRNAWalker2 validate; MirTarget; miRNATAP -0.32 0 NA
62 hsa-miR-16-5p CASR 0.75 0 -0.85 0.20015 miRNATAP -0.44 0.01985 NA
63 hsa-miR-193b-3p CBX7 1.1 0.00082 -1.83 0 MirTarget; miRNATAP -0.15 0 NA
64 hsa-miR-16-5p CCDC149 0.75 0 0.09 0.52509 MirTarget -0.13 0.00101 NA
65 hsa-miR-193b-3p CCDC28A 1.1 0.00082 -0.59 1.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.11 0 NA
66 hsa-miR-16-5p CCND1 0.75 0 -0.3 0.2554 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.37 0 23991964; 22922827; 18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL
67 hsa-miR-193b-3p CCND1 1.1 0.00082 -0.3 0.2554 miRNAWalker2 validate; miRTarBase; MirTarget -0.15 4.0E-5 27071318; 20655737; 20304954; 21893020; 26129688 MicroRNA 193b inhibits the proliferation migration and invasion of gastric cancer cells via targeting cyclin D1; Further mechanism study indicated that CCND1 was a direct target of miR-193b in GC;CCND1 and ETS1 were revealed to be regulated by miR-193b directly;MicroRNA 193b represses cell proliferation and regulates cyclin D1 in melanoma; Overexpression of miR-193b in Malme-3M cells down-regulated CCND1 mRNA and protein by > or = 50%; A luciferase reporter assay confirmed that miR-193b directly regulates CCND1 by binding to the 3'untranslated region of CCND1 mRNA; These studies indicate that miR-193b represses cell proliferation and regulates CCND1 expression and suggest that dysregulation of miR-193b may play an important role in melanoma development;In a previous study we reported that miR-193b represses cell proliferation and regulates cyclin D1 in melanoma cells suggesting that miR-193b could act as a tumor suppressor;Epigenetically altered miR 193b targets cyclin D1 in prostate cancer; It has been suggested that miR-193b targets cyclin D1 in several malignancies; Here our aim was to determine if miR-193b targets cyclin D1 in prostate cancer; Furthermore the PC cell lines 22Rv1 and VCaP which express low levels of miR-193b and high levels of CCND1 showed significant growth retardation when treated with a CDK4/6 inhibitor; In contrast the inhibitor had no effect on the growth of PC-3 and DU145 cells with high miR-193b and low CCND1 expression; Taken together our data demonstrate that miR-193b targets cyclin D1 in prostate cancer
68 hsa-miR-16-5p CCND2 0.75 0 -1.64 0 miRNAWalker2 validate; miRNATAP -0.14 0.04485 NA
69 hsa-miR-16-5p CCNT1 0.75 0 -0.35 0.14552 miRNATAP -0.17 0.01297 NA
70 hsa-miR-193b-3p CD244 1.1 0.00082 -1.68 0 MirTarget -0.12 0.00242 NA
71 hsa-miR-193b-3p CD47 1.1 0.00082 -0.76 2.0E-5 miRNATAP -0.11 0 NA
72 hsa-miR-16-5p CD55 0.75 0 -0.85 0.00259 miRNAWalker2 validate -0.2 0.01275 NA
73 hsa-miR-16-5p CHD3 0.75 0 -0.24 0.10005 miRNAWalker2 validate -0.1 0.01367 NA
74 hsa-miR-16-5p CHD9 0.75 0 -0.37 0.00502 miRNATAP -0.13 0.00063 NA
75 hsa-miR-193b-3p CHDH 1.1 0.00082 0.04 0.88061 miRNAWalker2 validate -0.16 1.0E-5 NA
76 hsa-miR-16-5p CLIP2 0.75 0 -0.66 0.00205 miRNAWalker2 validate -0.2 0.00116 NA
77 hsa-miR-16-5p CNN1 0.75 0 -1.86 0 miRNATAP -0.56 0 NA
78 hsa-miR-16-5p CNN3 0.75 0 -0.91 0 miRNAWalker2 validate -0.12 0.01878 NA
79 hsa-miR-16-5p CNNM2 0.75 0 -0.17 0.18962 miRNAWalker2 validate -0.16 1.0E-5 NA
80 hsa-miR-16-5p CNTNAP1 0.75 0 -0.07 0.73858 MirTarget -0.19 0.00046 NA
81 hsa-miR-16-5p COBLL1 0.75 0 -0.94 0 MirTarget; miRNATAP -0.13 0.01563 NA
82 hsa-miR-16-5p COL12A1 0.75 0 -0.85 0.03497 MirTarget; miRNATAP -0.6 0 NA
83 hsa-miR-16-5p COL4A1 0.75 0 -0.17 0.44496 miRNAWalker2 validate -0.31 0 NA
84 hsa-miR-16-5p COL4A2 0.75 0 -0.62 0.00595 miRNAWalker2 validate -0.32 0 NA
85 hsa-miR-16-5p COL4A4 0.75 0 -1.76 0 mirMAP -0.44 2.0E-5 NA
86 hsa-miR-16-5p CPD 0.75 0 0.91 9.0E-5 MirTarget; miRNATAP -0.2 0.00277 NA
87 hsa-miR-16-5p CREB3L2 0.75 0 0.46 0.00403 miRNAWalker2 validate -0.2 1.0E-5 NA
88 hsa-miR-16-5p CRIM1 0.75 0 -1.64 0 MirTarget; miRNATAP -0.26 2.0E-5 NA
89 hsa-miR-16-5p CRTC3 0.75 0 -0.61 0 miRNATAP -0.17 0 NA
90 hsa-miR-16-5p CSGALNACT1 0.75 0 -0.94 5.0E-5 miRNAWalker2 validate -0.33 0 NA
91 hsa-miR-193b-3p CSRNP1 1.1 0.00082 -2.37 0 MirTarget -0.15 0 NA
92 hsa-miR-16-5p CTDSPL 0.75 0 -1.17 0 miRNATAP -0.17 0.00021 NA
93 hsa-miR-193b-3p CTNND2 1.1 0.00082 -3.29 3.0E-5 MirTarget -0.24 0.02878 NA
94 hsa-miR-16-5p CX3CL1 0.75 0 -1.34 0.00024 miRNATAP -0.35 0.00085 NA
95 hsa-miR-16-5p CYB561D1 0.75 0 -0.67 2.0E-5 mirMAP -0.13 0.00483 NA
96 hsa-miR-16-5p CYS1 0.75 0 -2.41 0 mirMAP -0.62 0 NA
97 hsa-miR-16-5p DAB2IP 0.75 0 -1.15 0 mirMAP -0.13 0.0052 NA
98 hsa-miR-16-5p DCLK1 0.75 0 0.49 0.16376 miRNATAP -0.21 0.034 NA
99 hsa-miR-16-5p DENND2C 0.75 0 -1.18 0 MirTarget -0.16 0.01771 NA
100 hsa-miR-16-5p DGCR2 0.75 0 -0.08 0.53184 mirMAP -0.12 0.00073 NA
101 hsa-miR-16-5p DIXDC1 0.75 0 -1.41 0 miRNAWalker2 validate; MirTarget -0.24 0 NA
102 hsa-miR-16-5p DLL1 0.75 0 -1.1 0.0002 miRNATAP -0.17 0.04204 NA
103 hsa-miR-16-5p DLL4 0.75 0 -0.95 0 miRNATAP -0.24 3.0E-5 NA
104 hsa-miR-16-5p DMD 0.75 0 -1.31 0 miRNAWalker2 validate -0.22 0.00534 NA
105 hsa-miR-16-5p DOCK5 0.75 0 0.05 0.85899 miRNAWalker2 validate -0.23 0.00333 NA
106 hsa-miR-16-5p DOCK9 0.75 0 -1.09 0 miRNAWalker2 validate -0.25 0 NA
107 hsa-miR-193b-3p DOK2 1.1 0.00082 -2.1 0 miRNAWalker2 validate -0.19 0 NA
108 hsa-miR-16-5p DSEL 0.75 0 -0.89 0.00132 MirTarget; miRNATAP -0.22 0.0048 NA
109 hsa-miR-16-5p DYNC1I1 0.75 0 -0.11 0.77685 MirTarget; miRNATAP -0.27 0.01101 NA
110 hsa-miR-16-5p DZIP1 0.75 0 -0.74 0.00147 MirTarget -0.22 0.00084 NA
111 hsa-miR-16-5p EDA 0.75 0 -1.4 0.00012 MirTarget; miRNATAP -0.26 0.01246 NA
112 hsa-miR-16-5p EFNB2 0.75 0 -1.34 0 miRNAWalker2 validate; miRNATAP -0.15 0.03486 NA
113 hsa-miR-193b-3p EFS 1.1 0.00082 -0.23 0.50256 miRNAWalker2 validate -0.12 0.00841 NA
114 hsa-miR-16-5p EGFR 0.75 0 -0.27 0.42339 miRNAWalker2 validate -0.24 0.01364 NA
115 hsa-miR-16-5p ELMOD1 0.75 0 -2.82 0 MirTarget -0.22 0.04669 NA
116 hsa-miR-16-5p EML4 0.75 0 0.36 0.01118 miRNAWalker2 validate -0.12 0.00303 NA
117 hsa-miR-16-5p ENAH 0.75 0 0.52 0.00055 MirTarget; miRNATAP -0.1 0.01845 NA
118 hsa-miR-193b-3p ENAM 1.1 0.00082 -1.28 0.03627 MirTarget -0.43 0 NA
119 hsa-miR-193b-3p ENDOD1 1.1 0.00082 0.06 0.80229 miRNAWalker2 validate -0.19 0 NA
120 hsa-miR-16-5p ENTPD7 0.75 0 0.96 0 MirTarget -0.14 0.00598 NA
121 hsa-miR-16-5p EPB41L1 0.75 0 -0.29 0.0609 MirTarget -0.14 0.00185 NA
122 hsa-miR-193b-3p EPDR1 1.1 0.00082 -0.82 0.00766 miRNAWalker2 validate -0.15 0.00043 NA
123 hsa-miR-16-5p EPHA1 0.75 0 0.65 0.02083 miRNATAP -0.17 0.03195 NA
124 hsa-miR-193b-3p ERBB4 1.1 0.00082 -3.26 0 MirTarget; miRNATAP -0.46 0 NA
125 hsa-miR-193b-3p ESR1 1.1 0.00082 -0.26 0.51027 miRNAWalker2 validate; miRTarBase -0.17 0.00122 NA
126 hsa-miR-16-5p ESRRG 0.75 0 -0.63 0.20865 miRNATAP -0.29 0.03971 NA
127 hsa-miR-193b-3p ETV1 1.1 0.00082 -1.79 0 MirTarget; miRNATAP -0.33 0 NA
128 hsa-miR-16-5p EXOC3L2 0.75 0 -0.55 0.01351 miRNATAP -0.14 0.02148 NA
129 hsa-miR-16-5p EYA4 0.75 0 -2.93 0 MirTarget -0.42 0.00292 NA
130 hsa-miR-16-5p FAM168A 0.75 0 -0.32 0.09708 miRNAWalker2 validate -0.22 7.0E-5 NA
131 hsa-miR-16-5p FAM189A1 0.75 0 -3.26 0 MirTarget; miRNATAP -0.42 0.00096 NA
132 hsa-miR-16-5p FAM69A 0.75 0 0.75 1.0E-5 miRNAWalker2 validate -0.17 0.00044 NA
133 hsa-miR-16-5p FAM81A 0.75 0 1.3 2.0E-5 miRNATAP -0.18 0.03302 NA
134 hsa-miR-16-5p FAM84B 0.75 0 0.47 0.02615 MirTarget -0.15 0.00989 NA
135 hsa-miR-16-5p FAM89A 0.75 0 -0.97 6.0E-5 miRNAWalker2 validate; MirTarget -0.16 0.02193 NA
136 hsa-miR-16-5p FAT3 0.75 0 -3.31 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.42 0.00109 NA
137 hsa-miR-16-5p FAT4 0.75 0 -1.94 0 MirTarget -0.34 6.0E-5 NA
138 hsa-miR-193b-3p FAT4 1.1 0.00082 -1.94 0 MirTarget; miRNATAP -0.29 0 NA
139 hsa-miR-16-5p FBXO21 0.75 0 -0.44 0.00017 MirTarget; miRNATAP -0.13 7.0E-5 NA
140 hsa-miR-193b-3p FCHSD2 1.1 0.00082 -0.52 0 MirTarget -0.1 0 NA
141 hsa-miR-16-5p FERMT2 0.75 0 -1.54 0 MirTarget; miRNATAP -0.12 0.01599 NA
142 hsa-miR-16-5p FGF18 0.75 0 -2.02 0 miRNATAP -0.28 0.02063 NA
143 hsa-miR-16-5p FGF7 0.75 0 -1.35 0 miRNATAP -0.36 0 NA
144 hsa-miR-16-5p FGF9 0.75 0 -1.33 0.01194 miRNATAP -0.47 0.00195 NA
145 hsa-miR-16-5p FGFR1 0.75 0 -0.92 0.00029 miRTarBase; miRNATAP -0.25 0.00056 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration
146 hsa-miR-193b-3p FHDC1 1.1 0.00082 -1.23 0 MirTarget; miRNATAP -0.1 0.00061 NA
147 hsa-miR-193b-3p FLI1 1.1 0.00082 -1.88 0 MirTarget -0.17 0 NA
148 hsa-miR-16-5p FLNA 0.75 0 -0.92 5.0E-5 miRNAWalker2 validate -0.29 1.0E-5 NA
149 hsa-miR-193b-3p FLRT3 1.1 0.00082 -2.43 0 MirTarget; miRNATAP -0.29 0 NA
150 hsa-miR-16-5p FNDC3B 0.75 0 0.22 0.12432 miRNAWalker2 validate; MirTarget -0.1 0.0124 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CARDIOVASCULAR SYSTEM DEVELOPMENT 65 788 1.176e-18 2.735e-15
2 CIRCULATORY SYSTEM DEVELOPMENT 65 788 1.176e-18 2.735e-15
3 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 58 689 4.068e-17 6.309e-14
4 REGULATION OF CELLULAR COMPONENT MOVEMENT 60 771 4.348e-16 5.058e-13
5 TISSUE DEVELOPMENT 89 1518 9.425e-16 8.771e-13
6 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 65 957 1.645e-14 1.276e-11
7 ORGAN MORPHOGENESIS 60 841 2.201e-14 1.423e-11
8 REGULATION OF CELL DIFFERENTIATION 85 1492 2.447e-14 1.423e-11
9 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 91 1672 3.705e-14 1.916e-11
10 VASCULATURE DEVELOPMENT 42 469 1.485e-13 6.912e-11
11 NEUROGENESIS 79 1402 4.243e-13 1.795e-10
12 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 74 1275 6.292e-13 2.44e-10
13 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 42 498 1.102e-12 3.945e-10
14 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 63 1008 1.774e-12 5.895e-10
15 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 68 1142 1.957e-12 6.07e-10
16 CELL DEVELOPMENT 78 1426 2.761e-12 8.031e-10
17 RESPONSE TO GROWTH FACTOR 40 475 4.103e-12 1.123e-09
18 NEGATIVE REGULATION OF CELL COMMUNICATION 69 1192 4.831e-12 1.249e-09
19 TISSUE MORPHOGENESIS 42 533 1.007e-11 2.411e-09
20 EMBRYO DEVELOPMENT 57 894 1.036e-11 2.411e-09
21 REGULATION OF PHOSPHORUS METABOLIC PROCESS 83 1618 1.377e-11 3.05e-09
22 BIOLOGICAL ADHESION 62 1032 1.448e-11 3.063e-09
23 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 61 1021 2.709e-11 5.479e-09
24 HEART DEVELOPMENT 38 466 3.754e-11 7.279e-09
25 RESPONSE TO ENDOGENOUS STIMULUS 76 1450 4.294e-11 7.993e-09
26 HEAD DEVELOPMENT 48 709 6.714e-11 1.202e-08
27 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 72 1360 9.722e-11 1.675e-08
28 POSITIVE REGULATION OF LOCOMOTION 35 420 1.269e-10 1.789e-08
29 INTRACELLULAR SIGNAL TRANSDUCTION 79 1572 1.268e-10 1.789e-08
30 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 73 1395 1.195e-10 1.789e-08
31 TUBE DEVELOPMENT 41 552 1.122e-10 1.789e-08
32 LOCOMOTION 63 1114 1.211e-10 1.789e-08
33 CENTRAL NERVOUS SYSTEM DEVELOPMENT 54 872 1.132e-10 1.789e-08
34 REGULATION OF CELL DEVELOPMENT 52 836 2.207e-10 2.954e-08
35 EXTRACELLULAR STRUCTURE ORGANIZATION 29 304 2.222e-10 2.954e-08
36 EPITHELIUM DEVELOPMENT 56 945 2.612e-10 3.376e-08
37 REGULATION OF PROTEIN MODIFICATION PROCESS 82 1710 5.153e-10 6.48e-08
38 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 80 1656 6.196e-10 7.586e-08
39 EMBRYONIC MORPHOGENESIS 39 539 6.951e-10 8.293e-08
40 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 86 1848 7.848e-10 9.129e-08
41 BLOOD VESSEL MORPHOGENESIS 31 364 8.826e-10 1.002e-07
42 CELLULAR COMPONENT MORPHOGENESIS 53 900 1.028e-09 1.139e-07
43 SKELETAL SYSTEM DEVELOPMENT 35 455 1.092e-09 1.181e-07
44 POSITIVE REGULATION OF CELL DIFFERENTIATION 50 823 1.123e-09 1.188e-07
45 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 24 229 1.247e-09 1.289e-07
46 PROTEIN PHOSPHORYLATION 54 944 1.974e-09 1.997e-07
47 MORPHOGENESIS OF AN EPITHELIUM 32 400 2.222e-09 2.2e-07
48 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 29 337 2.463e-09 2.387e-07
49 REGULATION OF CELL PROLIFERATION 73 1496 2.602e-09 2.47e-07
50 NEURON DIFFERENTIATION 51 874 2.973e-09 2.767e-07
51 CELL MOTILITY 49 835 5.186e-09 4.641e-07
52 LOCALIZATION OF CELL 49 835 5.186e-09 4.641e-07
53 POSITIVE REGULATION OF RESPONSE TO STIMULUS 86 1929 6.159e-09 5.407e-07
54 REGULATION OF GROWTH 41 633 6.43e-09 5.54e-07
55 ANGIOGENESIS 26 293 8.862e-09 7.497e-07
56 REGULATION OF CELL MORPHOGENESIS 37 552 1.494e-08 1.241e-06
57 REGULATION OF EPITHELIAL CELL MIGRATION 19 166 1.594e-08 1.301e-06
58 POSITIVE REGULATION OF CELL COMMUNICATION 72 1532 1.623e-08 1.302e-06
59 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 55 1036 1.871e-08 1.451e-06
60 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 55 1036 1.871e-08 1.451e-06
61 REGULATION OF EPITHELIAL CELL PROLIFERATION 25 285 2.161e-08 1.622e-06
62 POSITIVE REGULATION OF MOLECULAR FUNCTION 80 1791 2.147e-08 1.622e-06
63 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 35 513 2.391e-08 1.766e-06
64 REGULATION OF DEVELOPMENTAL GROWTH 25 289 2.849e-08 2.071e-06
65 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 85 1977 4.029e-08 2.884e-06
66 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 12 66 4.218e-08 2.929e-06
67 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 12 66 4.218e-08 2.929e-06
68 NEGATIVE REGULATION OF CELL DIFFERENTIATION 38 609 6.27e-08 4.29e-06
69 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 14 99 8.799e-08 5.849e-06
70 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 14 99 8.799e-08 5.849e-06
71 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 43 750 9.186e-08 6.02e-06
72 DEVELOPMENTAL GROWTH 26 333 1.184e-07 7.653e-06
73 POSITIVE REGULATION OF CELL PROLIFERATION 45 814 1.296e-07 8.152e-06
74 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 14 102 1.29e-07 8.152e-06
75 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 14 103 1.461e-07 9.067e-06
76 REGULATION OF NEURON DIFFERENTIATION 35 554 1.573e-07 9.63e-06
77 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 56 1135 1.622e-07 9.804e-06
78 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 77 1784 1.705e-07 1.017e-05
79 HEART MORPHOGENESIS 20 212 1.733e-07 1.021e-05
80 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 15 121 1.816e-07 1.056e-05
81 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 44 801 2.153e-07 1.237e-05
82 REGULATION OF KINASE ACTIVITY 43 776 2.351e-07 1.334e-05
83 REGULATION OF CHEMOTAXIS 18 180 3.011e-07 1.688e-05
84 POSITIVE REGULATION OF MAPK CASCADE 31 470 3.24e-07 1.753e-05
85 NEURON PROJECTION DEVELOPMENT 34 545 3.186e-07 1.753e-05
86 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 50 983 3.217e-07 1.753e-05
87 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 16 144 3.279e-07 1.754e-05
88 ACTIN FILAMENT BASED PROCESS 30 450 4.018e-07 2.121e-05
89 REGULATION OF CELL ADHESION 37 629 4.057e-07 2.121e-05
90 CELL JUNCTION ASSEMBLY 15 129 4.231e-07 2.187e-05
91 CELL JUNCTION ORGANIZATION 18 185 4.532e-07 2.317e-05
92 NEURON DEVELOPMENT 39 687 4.806e-07 2.405e-05
93 REGULATION OF MAPK CASCADE 38 660 4.791e-07 2.405e-05
94 REGULATION OF TRANSPORT 76 1804 5.398e-07 2.672e-05
95 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 76 1805 5.516e-07 2.673e-05
96 REGULATION OF CELL PROJECTION ORGANIZATION 34 558 5.477e-07 2.673e-05
97 GROWTH 28 410 6.093e-07 2.923e-05
98 CIRCULATORY SYSTEM PROCESS 26 366 7.36e-07 3.495e-05
99 TUBE MORPHOGENESIS 24 323 8.896e-07 4.181e-05
100 EXOCRINE SYSTEM DEVELOPMENT 9 45 9.081e-07 4.221e-05
101 CELL PROJECTION ORGANIZATION 46 902 9.162e-07 4.221e-05
102 GLAND DEVELOPMENT 27 395 9.524e-07 4.345e-05
103 EYE DEVELOPMENT 24 326 1.049e-06 4.738e-05
104 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 33 554 1.329e-06 5.945e-05
105 INOSITOL LIPID MEDIATED SIGNALING 14 124 1.469e-06 6.508e-05
106 REGULATION OF WNT SIGNALING PATHWAY 23 310 1.541e-06 6.763e-05
107 REGULATION OF NEURON PROJECTION DEVELOPMENT 27 408 1.769e-06 7.694e-05
108 SOMITOGENESIS 10 62 1.814e-06 7.814e-05
109 CELL SUBSTRATE ADHESION 16 164 1.899e-06 8.106e-05
110 PHOSPHORYLATION 56 1228 1.967e-06 8.319e-05
111 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 18 207 2.331e-06 9.771e-05
112 POSITIVE REGULATION OF CATALYTIC ACTIVITY 65 1518 2.359e-06 9.798e-05
113 SENSORY ORGAN DEVELOPMENT 30 493 2.644e-06 0.0001089
114 REGULATION OF AXON GUIDANCE 8 39 3.027e-06 0.0001225
115 MESENCHYME DEVELOPMENT 17 190 3.013e-06 0.0001225
116 REGULATION OF ENDOTHELIAL CELL MIGRATION 13 114 3.106e-06 0.0001246
117 REGULATION OF TRANSFERASE ACTIVITY 46 946 3.311e-06 0.0001316
118 NEGATIVE REGULATION OF PHOSPHORYLATION 27 422 3.336e-06 0.0001316
119 RESPONSE TO LIPID 44 888 3.387e-06 0.0001324
120 POSITIVE REGULATION OF GENE EXPRESSION 71 1733 3.663e-06 0.0001419
121 CELL CELL ADHESION 34 608 3.694e-06 0.0001419
122 MESENCHYMAL CELL DIFFERENTIATION 14 134 3.719e-06 0.0001419
123 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 10 67 3.764e-06 0.0001424
124 WNT SIGNALING PATHWAY 24 351 3.81e-06 0.000143
125 NEURON PROJECTION MORPHOGENESIS 26 402 4.171e-06 0.0001553
126 POSITIVE REGULATION OF GROWTH 19 238 4.351e-06 0.0001607
127 CELL SUBSTRATE JUNCTION ASSEMBLY 8 41 4.509e-06 0.0001652
128 FOREBRAIN DEVELOPMENT 24 357 5.089e-06 0.000185
129 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 63 1492 5.393e-06 0.0001945
130 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 31 541 6.139e-06 0.000218
131 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 31 541 6.139e-06 0.000218
132 ODONTOGENESIS 12 105 7.255e-06 0.0002557
133 SALIVARY GLAND DEVELOPMENT 7 32 8.092e-06 0.0002831
134 SEGMENTATION 11 89 8.157e-06 0.0002832
135 RESPONSE TO HORMONE 43 893 8.941e-06 0.0003082
136 CARTILAGE DEVELOPMENT 14 147 1.096e-05 0.000375
137 REGULATION OF AXONOGENESIS 15 168 1.173e-05 0.0003983
138 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 5 14 1.228e-05 0.0004111
139 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 5 14 1.228e-05 0.0004111
140 APPENDAGE DEVELOPMENT 15 169 1.26e-05 0.0004146
141 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 42 876 1.265e-05 0.0004146
142 LIMB DEVELOPMENT 15 169 1.26e-05 0.0004146
143 POSITIVE REGULATION OF KINASE ACTIVITY 28 482 1.349e-05 0.000439
144 CELLULAR RESPONSE TO LIPID 27 457 1.425e-05 0.0004604
145 MUSCLE STRUCTURE DEVELOPMENT 26 432 1.491e-05 0.0004784
146 SOMITE DEVELOPMENT 10 78 1.514e-05 0.0004824
147 REGULATION OF CARTILAGE DEVELOPMENT 9 63 1.663e-05 0.0005262
148 SEMAPHORIN PLEXIN SIGNALING PATHWAY 7 36 1.849e-05 0.0005813
149 GLAND MORPHOGENESIS 11 97 1.875e-05 0.0005815
150 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 14 154 1.863e-05 0.0005815
151 CELL GROWTH 13 135 1.999e-05 0.0006159
152 CELL PART MORPHOGENESIS 33 633 2.168e-05 0.0006549
153 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 43 926 2.145e-05 0.0006549
154 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 14 156 2.156e-05 0.0006549
155 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 12 117 2.205e-05 0.000662
156 CARDIAC MUSCLE CELL ACTION POTENTIAL 7 37 2.234e-05 0.0006664
157 RESPONSE TO STEROID HORMONE 28 497 2.349e-05 0.0006916
158 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 27 470 2.337e-05 0.0006916
159 POSITIVE REGULATION OF CELL DEVELOPMENT 27 472 2.517e-05 0.0007367
160 SKELETAL SYSTEM MORPHOGENESIS 16 201 2.55e-05 0.0007417
161 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 23 368 2.566e-05 0.0007417
162 REGULATION OF CELL DEATH 60 1472 2.646e-05 0.0007599
163 PLASMA MEMBRANE ORGANIZATION 16 203 2.88e-05 0.000822
164 CARDIAC MUSCLE TISSUE DEVELOPMENT 13 140 2.945e-05 0.0008357
165 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 32 616 3.095e-05 0.0008727
166 ORGAN GROWTH 9 68 3.118e-05 0.0008739
167 REGULATION OF BODY FLUID LEVELS 28 506 3.233e-05 0.0008942
168 PALATE DEVELOPMENT 10 85 3.248e-05 0.0008942
169 HEART PROCESS 10 85 3.248e-05 0.0008942
170 POSITIVE REGULATION OF CELL ADHESION 23 376 3.589e-05 0.0009823
171 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 11 104 3.623e-05 0.0009859
172 REGULATION OF HYDROLASE ACTIVITY 55 1327 3.766e-05 0.001019
173 PEPTIDYL TYROSINE MODIFICATION 15 186 3.905e-05 0.00105
174 NEGATIVE REGULATION OF CELL DEVELOPMENT 20 303 4.013e-05 0.001067
175 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 20 303 4.013e-05 0.001067
176 SINGLE ORGANISM CELL ADHESION 26 459 4.184e-05 0.001106
177 EMBRYONIC ORGAN DEVELOPMENT 24 406 4.213e-05 0.001108
178 REPRODUCTIVE SYSTEM DEVELOPMENT 24 408 4.554e-05 0.00119
179 RESPONSE TO ESTRADIOL 13 146 4.58e-05 0.001191
180 PLATELET DEGRANULATION 11 107 4.723e-05 0.001221
181 GLANDULAR EPITHELIAL CELL DEVELOPMENT 5 18 4.859e-05 0.001242
182 PERICARDIUM DEVELOPMENT 5 18 4.859e-05 0.001242
183 STEM CELL DIFFERENTIATION 15 190 4.992e-05 0.001262
184 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 15 190 4.992e-05 0.001262
185 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 17 236 5.138e-05 0.001292
186 FORMATION OF PRIMARY GERM LAYER 11 110 6.099e-05 0.001518
187 NEGATIVE REGULATION OF LOCOMOTION 18 263 6.073e-05 0.001518
188 MORPHOGENESIS OF AN EPITHELIAL SHEET 7 43 6.186e-05 0.001531
189 EMBRYONIC PATTERN SPECIFICATION 8 58 6.359e-05 0.001557
190 CONNECTIVE TISSUE DEVELOPMENT 15 194 6.335e-05 0.001557
191 REGULATION OF CELL GROWTH 23 391 6.535e-05 0.001592
192 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 44 1004 6.734e-05 0.001632
193 RETINA DEVELOPMENT IN CAMERA TYPE EYE 12 131 6.775e-05 0.001633
194 ARTERY DEVELOPMENT 9 75 6.865e-05 0.001638
195 NEURAL CREST CELL DIFFERENTIATION 9 75 6.865e-05 0.001638
196 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 13 152 6.954e-05 0.001651
197 REGULATION OF GTPASE ACTIVITY 33 673 7.175e-05 0.001695
198 SECRETION 30 588 7.568e-05 0.001778
199 REGULATION OF STEM CELL DIFFERENTIATION 11 113 7.805e-05 0.001825
200 GASTRULATION 13 155 8.498e-05 0.001967
201 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 10 95 8.496e-05 0.001967
202 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 35 740 8.897e-05 0.002049
203 BONE DEVELOPMENT 13 156 9.074e-05 0.00208
204 REGULATION OF CHONDROCYTE DIFFERENTIATION 7 46 9.665e-05 0.002204
205 UROGENITAL SYSTEM DEVELOPMENT 19 299 0.0001029 0.002325
206 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 18 274 0.0001025 0.002325
207 DENDRITE DEVELOPMENT 9 79 0.0001035 0.002326
208 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 46 1087 0.0001045 0.002337
209 MUSCLE TISSUE DEVELOPMENT 18 275 0.0001074 0.00239
210 POSITIVE REGULATION OF TRANSPORT 41 936 0.0001212 0.002685
211 TAXIS 25 464 0.0001293 0.002851
212 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 24 437 0.0001317 0.002869
213 HEMIDESMOSOME ASSEMBLY 4 12 0.0001326 0.002869
214 ADHERENS JUNCTION ASSEMBLY 6 34 0.0001314 0.002869
215 MAMMARY GLAND EPITHELIAL CELL PROLIFERATION 4 12 0.0001326 0.002869
216 POSITIVE REGULATION OF CHEMOTAXIS 11 120 0.0001344 0.002895
217 PROTEIN LOCALIZATION TO CELL SURFACE 5 22 0.0001381 0.002961
218 POSITIVE REGULATION OF NEURON DIFFERENTIATION 19 306 0.0001392 0.00297
219 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 16 232 0.000141 0.002995
220 REGULATION OF EXTENT OF CELL GROWTH 10 101 0.0001424 0.003012
221 CELLULAR RESPONSE TO HORMONE STIMULUS 28 552 0.0001441 0.003034
222 REGULATION OF RESPONSE TO WOUNDING 23 413 0.0001477 0.003091
223 REGULATION OF VASCULATURE DEVELOPMENT 16 233 0.0001482 0.003091
224 NEGATIVE REGULATION OF CELL PROLIFERATION 31 643 0.0001602 0.003328
225 SKIN DEVELOPMENT 15 211 0.0001622 0.003355
226 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 7 50 0.0001662 0.003403
227 FACE DEVELOPMENT 7 50 0.0001662 0.003403
228 FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 9 84 0.0001668 0.003403
229 CARDIAC CHAMBER DEVELOPMENT 12 144 0.0001678 0.003406
230 REGULATION OF ANATOMICAL STRUCTURE SIZE 25 472 0.0001684 0.003406
231 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 30 616 0.0001714 0.003452
232 PATTERN SPECIFICATION PROCESS 23 418 0.000176 0.00353
233 SYNAPSE ORGANIZATION 12 145 0.0001791 0.003573
234 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 8 67 0.0001797 0.003573
235 CARDIAC SEPTUM DEVELOPMENT 9 85 0.0001827 0.003617
236 TYPE B PANCREATIC CELL DEVELOPMENT 4 13 0.0001879 0.003705
237 CEREBRAL CORTEX DEVELOPMENT 10 105 0.0001966 0.00386
238 RESPONSE TO WOUNDING 28 563 0.0001996 0.003886
239 RESPONSE TO OXYGEN CONTAINING COMPOUND 54 1381 0.0001995 0.003886
240 REGULATION OF MUSCLE CONTRACTION 12 147 0.0002037 0.003949
241 DIGESTIVE SYSTEM DEVELOPMENT 12 148 0.000217 0.004189
242 RESPONSE TO ESTROGEN 15 218 0.0002316 0.004453
243 REGULATION OF MUSCLE SYSTEM PROCESS 14 195 0.0002402 0.004599
244 NEGATIVE REGULATION OF AXON EXTENSION 6 38 0.000249 0.004728
245 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 6 38 0.000249 0.004728
246 TUBE FORMATION 11 129 0.0002546 0.004816
247 REGULATION OF BLOOD CIRCULATION 18 295 0.0002564 0.004829
248 RESPIRATORY SYSTEM DEVELOPMENT 14 197 0.0002668 0.005005
249 ENDODERM DEVELOPMENT 8 71 0.0002699 0.005043
250 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 18 297 0.0002783 0.005179
251 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 22 404 0.0002796 0.005183
252 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 12 153 0.0002952 0.005451
253 REGULATION OF METAL ION TRANSPORT 19 325 0.0002996 0.005511
254 ENSHEATHMENT OF NEURONS 9 91 0.0003069 0.0056
255 AXON ENSHEATHMENT 9 91 0.0003069 0.0056
256 REGULATED EXOCYTOSIS 15 224 0.0003101 0.005636
257 REGULATION OF CELL CELL ADHESION 21 380 0.0003144 0.005692
258 RESPONSE TO ORGANIC CYCLIC COMPOUND 39 917 0.0003208 0.005786
259 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 11 133 0.0003319 0.005929
260 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 23 437 0.0003325 0.005929
261 HINDBRAIN MORPHOGENESIS 6 40 0.0003326 0.005929
262 REGULATION OF CELLULAR LOCALIZATION 50 1277 0.0003366 0.005979
263 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 7 56 0.0003416 0.006044
264 CELL PROLIFERATION 31 672 0.0003443 0.006068
265 MUSCLE ORGAN DEVELOPMENT 17 277 0.0003529 0.006196
266 CELL FATE COMMITMENT 15 227 0.0003573 0.00625
267 ACTIN MEDIATED CELL CONTRACTION 8 74 0.0003594 0.006263
268 ACTIN FILAMENT BASED MOVEMENT 9 93 0.0003613 0.006273
269 HIPPO SIGNALING 5 27 0.000384 0.00645
270 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 35 799 0.0003805 0.00645
271 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 11 135 0.0003774 0.00645
272 NEGATIVE REGULATION OF AXON GUIDANCE 5 27 0.000384 0.00645
273 EMBRYONIC ORGAN MORPHOGENESIS 17 279 0.0003833 0.00645
274 REGULATION OF CATENIN IMPORT INTO NUCLEUS 5 27 0.000384 0.00645
275 SUBSTRATE DEPENDENT CELL MIGRATION 5 27 0.000384 0.00645
276 ACTIVATION OF PROTEIN KINASE ACTIVITY 17 279 0.0003833 0.00645
277 TELENCEPHALON DEVELOPMENT 15 228 0.0003744 0.00645
278 WOUND HEALING 24 470 0.0003854 0.00645
279 HORMONE MEDIATED SIGNALING PATHWAY 12 158 0.0003962 0.006608
280 NEURON PROJECTION GUIDANCE 14 205 4e-04 0.006647
281 CANONICAL WNT SIGNALING PATHWAY 9 95 0.0004234 0.007011
282 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 6 42 0.0004367 0.007206
283 RESPONSE TO FIBROBLAST GROWTH FACTOR 10 116 0.0004414 0.007257
284 SECOND MESSENGER MEDIATED SIGNALING 12 160 0.0004441 0.007276
285 PARAXIAL MESODERM DEVELOPMENT 4 16 0.000452 0.00738
286 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 11 138 0.0004554 0.007409
287 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 14 208 0.0004629 0.007504
288 EXOCYTOSIS 18 310 0.0004646 0.007507
289 MAMMARY GLAND DEVELOPMENT 10 117 0.0004726 0.007583
290 DEVELOPMENTAL CELL GROWTH 8 77 0.0004717 0.007583
291 IN UTERO EMBRYONIC DEVELOPMENT 18 311 0.0004827 0.007691
292 REGIONALIZATION 18 311 0.0004827 0.007691
293 POSITIVE REGULATION OF HYDROLASE ACTIVITY 38 905 0.0004884 0.007756
294 REGULATION OF SYSTEM PROCESS 25 507 0.000491 0.007772
295 CEREBRAL CORTEX CELL MIGRATION 6 43 0.0004975 0.007847
296 DEPHOSPHORYLATION 17 286 0.0005086 0.007996
297 CHONDROCYTE DIFFERENTIATION 7 60 0.0005245 0.008217
298 CELL MATRIX ADHESION 10 119 0.0005406 0.008397
299 CARDIAC MUSCLE CELL CONTRACTION 5 29 0.0005432 0.008397
300 POSITIVE REGULATION OF CARTILAGE DEVELOPMENT 5 29 0.0005432 0.008397
301 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 10 119 0.0005406 0.008397
302 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 16 262 0.0005504 0.00848
303 MUSCLE CELL DIFFERENTIATION 15 237 0.0005618 0.008628
304 CAMP BIOSYNTHETIC PROCESS 4 17 0.0005801 0.008736
305 STRIATED MUSCLE CONTRACTION 9 99 0.000574 0.008736
306 REGULATION OF PLATELET AGGREGATION 4 17 0.0005801 0.008736
307 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 17 289 0.0005723 0.008736
308 RECEPTOR CATABOLIC PROCESS 4 17 0.0005801 0.008736
309 ACTIVATION OF PROTEIN KINASE A ACTIVITY 4 17 0.0005801 0.008736
310 SECRETION BY CELL 24 486 0.0006197 0.009191
311 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 12 166 0.0006179 0.009191
312 NEGATIVE REGULATION OF MOLECULAR FUNCTION 43 1079 0.0006203 0.009191
313 SENSORY ORGAN MORPHOGENESIS 15 239 0.000613 0.009191
314 PEPTIDYL TYROSINE DEPHOSPHORYLATION 9 100 0.0006178 0.009191
315 CEREBELLAR CORTEX MORPHOGENESIS 5 30 0.0006393 0.009354
316 SPROUTING ANGIOGENESIS 6 45 0.0006387 0.009354
317 REGULATION OF HEART RATE BY CARDIAC CONDUCTION 5 30 0.0006393 0.009354
318 CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 5 30 0.0006393 0.009354
319 NEGATIVE REGULATION OF SYNAPTIC TRANSMISSION 7 62 0.0006413 0.009354
320 SEX DIFFERENTIATION 16 266 0.0006483 0.009418
321 REGULATION OF MAP KINASE ACTIVITY 18 319 0.0006498 0.009418
322 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 12 168 0.0006872 0.009931
323 PROTEIN AUTOPHOSPHORYLATION 13 192 0.0006913 0.009959
NumGOOverlapSizeP ValueAdj. P Value
1 RECEPTOR BINDING 78 1476 1.521e-11 1.413e-08
2 PROTEIN KINASE ACTIVITY 45 640 8.08e-11 3.753e-08
3 CYTOSKELETAL PROTEIN BINDING 47 819 2.167e-08 5.033e-06
4 ACTIN BINDING 30 393 2.078e-08 5.033e-06
5 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 12 64 2.937e-08 5.458e-06
6 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 13 81 5.47e-08 7.26e-06
7 KINASE ACTIVITY 47 842 5.012e-08 7.26e-06
8 BETA CATENIN BINDING 13 84 8.549e-08 9.324e-06
9 MOLECULAR FUNCTION REGULATOR 64 1353 9.033e-08 9.324e-06
10 KINASE BINDING 36 606 4.629e-07 4.3e-05
11 ENZYME BINDING 74 1737 5.116e-07 4.321e-05
12 SMAD BINDING 11 72 9.692e-07 7.474e-05
13 PROTEIN TYROSINE KINASE ACTIVITY 17 176 1.046e-06 7.474e-05
14 GROWTH FACTOR BINDING 14 123 1.331e-06 8.833e-05
15 FRIZZLED BINDING 8 36 1.584e-06 9.813e-05
16 PROTEIN COMPLEX BINDING 46 935 2.426e-06 0.0001326
17 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 48 992 2.291e-06 0.0001326
18 TRANSCRIPTION FACTOR BINDING 30 524 8.821e-06 0.0004553
19 INSULIN LIKE GROWTH FACTOR BINDING 6 25 2.073e-05 0.001
20 HORMONE BINDING 9 65 2.153e-05 0.001
21 PROTEIN SERINE THREONINE KINASE ACTIVITY 26 445 2.481e-05 0.001098
22 G PROTEIN COUPLED RECEPTOR BINDING 18 259 4.979e-05 0.002103
23 PHOSPHATIDYLINOSITOL 3 KINASE BINDING 6 30 6.286e-05 0.002459
24 RECEPTOR SIGNALING PROTEIN ACTIVITY 14 172 6.353e-05 0.002459
25 PROTEIN DOMAIN SPECIFIC BINDING 31 624 9.368e-05 0.003481
26 LIPID BINDING 32 657 0.0001044 0.00373
27 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 16 228 0.0001152 0.003965
28 CALCIUM ION BINDING 33 697 0.0001386 0.004599
NumGOOverlapSizeP ValueAdj. P Value
1 CELL PROJECTION 92 1786 6.463e-13 3.774e-10
2 NEURON PART 71 1265 9.524e-12 1.854e-09
3 CELL JUNCTION 67 1151 8.037e-12 1.854e-09
4 NEURON PROJECTION 58 942 2.703e-11 3.946e-09
5 SOMATODENDRITIC COMPARTMENT 43 650 1.424e-09 1.663e-07
6 CELL SUBSTRATE JUNCTION 32 398 1.964e-09 1.912e-07
7 ANCHORING JUNCTION 34 489 2.404e-08 2.006e-06
8 INTRINSIC COMPONENT OF PLASMA MEMBRANE 75 1649 3.068e-08 2.239e-06
9 SYNAPSE 43 754 1.065e-07 6.221e-06
10 CELL PROJECTION PART 50 946 1.005e-07 6.221e-06
11 DENDRITE 31 451 1.309e-07 6.947e-06
12 ACTOMYOSIN 11 62 2.017e-07 9.818e-06
13 AXON 29 418 2.76e-07 1.24e-05
14 EXTRACELLULAR MATRIX 29 426 4.091e-07 1.691e-05
15 PROTEINACEOUS EXTRACELLULAR MATRIX 26 356 4.343e-07 1.691e-05
16 ACTIN FILAMENT BUNDLE 10 57 8.098e-07 2.956e-05
17 CYTOSKELETON 80 1967 1.053e-06 3.616e-05
18 MEMBRANE MICRODOMAIN 22 288 1.608e-06 4.975e-05
19 SARCOLEMMA 14 125 1.619e-06 4.975e-05
20 MEMBRANE REGION 53 1134 1.85e-06 5.401e-05
21 EXTRACELLULAR MATRIX COMPONENT 13 125 8.667e-06 0.000241
22 T TUBULE 8 45 9.361e-06 0.0002485
23 CELL LEADING EDGE 23 350 1.156e-05 0.0002935
24 POSTSYNAPSE 24 378 1.326e-05 0.0003227
25 CELL CELL JUNCTION 24 383 1.646e-05 0.0003845
26 EXCITATORY SYNAPSE 16 197 1.99e-05 0.0004305
27 AXON PART 17 219 1.987e-05 0.0004305
28 CELL BODY 28 494 2.107e-05 0.0004394
29 ACTIN CYTOSKELETON 26 444 2.388e-05 0.0004648
30 PLASMA MEMBRANE REGION 43 929 2.316e-05 0.0004648
31 INTRACELLULAR VESICLE 53 1259 3.492e-05 0.0006579
32 RECEPTOR COMPLEX 21 327 3.869e-05 0.000706
33 GOLGI APPARATUS 58 1445 5.606e-05 0.0009921
34 SYNAPSE PART 31 610 6.189e-05 0.001063
35 COSTAMERE 5 19 6.467e-05 0.001079
36 BASEMENT MEMBRANE 10 93 7.085e-05 0.001149
37 PLASMA MEMBRANE PROTEIN COMPLEX 27 510 9.397e-05 0.001483
38 CYTOPLASMIC REGION 18 287 0.000183 0.002741
39 LATE ENDOSOME 15 213 0.0001799 0.002741
40 CYTOSKELETAL PART 55 1436 0.000291 0.004248
41 SECRETORY GRANULE 20 352 0.0003039 0.004329
42 ENDOSOME 35 793 0.0003314 0.004608
43 PLATELET ALPHA GRANULE 8 75 0.0003941 0.005353
44 MAIN AXON 7 58 0.0004252 0.005644
45 CONTRACTILE FIBER 14 211 0.000534 0.00693
46 CATION CHANNEL COMPLEX 12 167 0.0006518 0.008275

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 26 199 1.688e-12 8.78e-11
2 PI3K_Akt_signaling_pathway_hsa04151 30 352 1.632e-09 4.243e-08
3 Rap1_signaling_pathway_hsa04015 19 206 4.992e-07 6.549e-06
4 ECM_receptor_interaction_hsa04512 12 82 5.037e-07 6.549e-06
5 Wnt_signaling_pathway_hsa04310 15 146 2.077e-06 2.161e-05
6 Adherens_junction_hsa04520 10 72 7.322e-06 6.17e-05
7 MAPK_signaling_pathway_hsa04010 21 295 8.306e-06 6.17e-05
8 Regulation_of_actin_cytoskeleton_hsa04810 17 208 1.014e-05 6.593e-05
9 Hippo_signaling_pathway_hsa04390 14 154 1.863e-05 0.0001077
10 mTOR_signaling_pathway_hsa04150 13 151 6.497e-05 0.0003378
11 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 11 139 0.0004842 0.002289
12 FoxO_signaling_pathway_hsa04068 10 132 0.001208 0.005237
13 Ras_signaling_pathway_hsa04014 14 232 0.001341 0.005365
14 HIF_1_signaling_pathway_hsa04066 8 100 0.002604 0.009274
15 VEGF_signaling_pathway_hsa04370 6 59 0.002675 0.009274
16 Hippo_signaling_pathway_multiple_species_hsa04392 4 29 0.004625 0.01503
17 Hedgehog_signaling_pathway_hsa04340 5 47 0.004951 0.01514
18 Apelin_signaling_pathway_hsa04371 9 137 0.005419 0.01565
19 Phospholipase_D_signaling_pathway_hsa04072 9 146 0.008124 0.02135
20 AMPK_signaling_pathway_hsa04152 8 121 0.008213 0.02135
21 Oocyte_meiosis_hsa04114 8 124 0.009456 0.02341
22 Cellular_senescence_hsa04218 9 160 0.01423 0.03363
23 cGMP_PKG_signaling_pathway_hsa04022 9 163 0.01589 0.03592
24 Gap_junction_hsa04540 6 88 0.0182 0.03942
25 Sphingolipid_signaling_pathway_hsa04071 7 118 0.02236 0.04652
26 Notch_signaling_pathway_hsa04330 4 48 0.02669 0.05338
27 Jak_STAT_signaling_pathway_hsa04630 8 162 0.03951 0.07609
28 TNF_signaling_pathway_hsa04668 6 108 0.0436 0.08097
29 cAMP_signaling_pathway_hsa04024 9 198 0.04689 0.08408
30 TGF_beta_signaling_pathway_hsa04350 5 84 0.0493 0.08545
31 ErbB_signaling_pathway_hsa04012 5 85 0.05141 0.08623
32 Calcium_signaling_pathway_hsa04020 8 182 0.06874 0.1117
33 p53_signaling_pathway_hsa04115 4 68 0.07776 0.1225
34 Autophagy_animal_hsa04140 6 128 0.08425 0.1283
35 Phosphatidylinositol_signaling_system_hsa04070 5 99 0.08635 0.1283
36 Ferroptosis_hsa04216 2 40 0.2448 0.3537
37 Cytokine_cytokine_receptor_interaction_hsa04060 8 270 0.3108 0.4369
38 Lysosome_hsa04142 4 123 0.3334 0.4518
39 Cell_cycle_hsa04110 4 124 0.3388 0.4518
40 Tight_junction_hsa04530 5 170 0.3769 0.49
41 Apoptosis_hsa04210 4 138 0.4141 0.5252
42 Cell_adhesion_molecules_.CAMs._hsa04514 4 145 0.4511 0.5585
43 Phagosome_hsa04145 4 152 0.4873 0.5893
44 Endocytosis_hsa04144 6 244 0.5212 0.6159
45 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.6621 0.765
46 Necroptosis_hsa04217 2 164 0.9034 1
47 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.9905 1

Quest ID: 08578c6024f6c2fb95931c961797e8f8