Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-130a-3p NRP1 -0.01 0.93453 0.11 0.41779 miRNATAP -0.18 0.00023 26573160 NRP1 is targeted by miR 130a and miR 130b and is associated with multidrug resistance in epithelial ovarian cancer based on integrated gene network analysis
2 hsa-miR-133b NRP1 -1.64 0 0.11 0.41779 miRanda -0.15 0 NA
3 hsa-miR-139-5p NRP1 -0.25 0.04065 0.11 0.41779 PITA; miRanda -0.14 0.00259 NA
4 hsa-miR-141-3p NRP1 1.8 0 0.11 0.41779 TargetScan; miRNATAP -0.12 0.00065 NA
5 hsa-miR-148a-3p NRP1 1.85 0 0.11 0.41779 miRNATAP -0.2 0 26967387 Mechanistically miR-148a appears to suppress the extravasation process of cancer cells likely by targeting two genes WNT1 and NRP1 in a cell non-autonomous manner
6 hsa-miR-186-5p NRP1 0.57 0 0.11 0.41779 miRNAWalker2 validate; mirMAP; miRNATAP -0.19 0.00921 NA
7 hsa-miR-214-3p NRP1 0.25 0.05575 0.11 0.41779 miRNATAP -0.15 0.00097 NA
8 hsa-miR-30a-5p NRP1 0.51 0 0.11 0.41779 mirMAP; miRNATAP -0.19 0.00027 NA
9 hsa-miR-30b-5p NRP1 1.17 0 0.11 0.41779 mirMAP -0.13 0.00248 NA
10 hsa-miR-30c-5p NRP1 0.75 0 0.11 0.41779 mirMAP; miRNATAP -0.29 0 NA
11 hsa-miR-30e-5p NRP1 -0.04 0.61092 0.11 0.41779 mirMAP -0.23 0.00128 NA
12 hsa-miR-320a NRP1 1 0 0.11 0.41779 PITA; miRanda; miRNATAP -0.12 0.01833 22134529 miR-320a directly binds to the 3'UTR of neuropilin 1 NRP-1 a protein that functions as a co-receptor of vascular epithelial growth factor
13 hsa-miR-324-5p NRP1 0.54 2.0E-5 0.11 0.41779 miRanda -0.12 0.00975 NA
14 hsa-miR-361-5p NRP1 0.65 0 0.11 0.41779 miRanda; miRNATAP -0.36 1.0E-5 NA
15 hsa-miR-374a-3p NRP1 0.61 0 0.11 0.41779 miRNATAP -0.14 0.02516 NA
16 hsa-miR-582-5p NRP1 0.31 0.04027 0.11 0.41779 PITA; miRNATAP -0.15 7.0E-5 NA
17 hsa-miR-590-3p NRP1 0.58 0 0.11 0.41779 PITA; miRanda; mirMAP -0.1 0.02839 NA
18 hsa-miR-590-5p NRP1 0.78 0 0.11 0.41779 miRanda -0.12 0.00685 NA
19 hsa-miR-664a-3p NRP1 0.77 0 0.11 0.41779 mirMAP -0.21 0.00023 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELLULAR COMPONENT MOVEMENT 14 771 2.055e-12 9.562e-09
2 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 14 1021 8.78e-11 2.043e-07
3 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 9 262 1.552e-10 2.408e-07
4 NEGATIVE REGULATION OF CELL DEVELOPMENT 9 303 5.62e-10 3.736e-07
5 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 12 750 5.191e-10 3.736e-07
6 REGULATION OF NEURON DIFFERENTIATION 11 554 3.42e-10 3.736e-07
7 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 16 1672 4.749e-10 3.736e-07
8 TAXIS 10 464 1.176e-09 6.839e-07
9 RESPONSE TO EXTERNAL STIMULUS 16 1821 1.67e-09 8.296e-07
10 REGULATION OF CELL DEVELOPMENT 12 836 1.783e-09 8.296e-07
11 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 11 684 3.135e-09 1.326e-06
12 LOCOMOTION 13 1114 3.733e-09 1.448e-06
13 NEGATIVE REGULATION OF LOCOMOTION 8 263 4.882e-09 1.667e-06
14 NEUROGENESIS 14 1402 5.542e-09 1.667e-06
15 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 13 1142 5.039e-09 1.667e-06
16 GLAND DEVELOPMENT 9 395 5.731e-09 1.667e-06
17 RESPONSE TO WOUNDING 10 563 7.514e-09 1.86e-06
18 REGULATION OF CELL PROJECTION ORGANIZATION 10 558 6.901e-09 1.86e-06
19 REGULATION OF NEURON PROJECTION DEVELOPMENT 9 408 7.593e-09 1.86e-06
20 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 12 983 1.102e-08 2.565e-06
21 MESENCHYME DEVELOPMENT 7 190 1.356e-08 3.004e-06
22 TISSUE DEVELOPMENT 14 1518 1.536e-08 3.249e-06
23 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 11 801 1.614e-08 3.264e-06
24 NEURON PROJECTION GUIDANCE 7 205 2.29e-08 4.44e-06
25 ORGAN MORPHOGENESIS 11 841 2.664e-08 4.959e-06
26 NEURON DIFFERENTIATION 11 874 3.953e-08 7.074e-06
27 MESENCHYMAL CELL DIFFERENTIATION 6 134 5.186e-08 8.534e-06
28 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 13 1395 5.502e-08 8.534e-06
29 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 9 513 5.465e-08 8.534e-06
30 CELLULAR COMPONENT MORPHOGENESIS 11 900 5.334e-08 8.534e-06
31 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 8 368 6.637e-08 9.963e-06
32 CELL DEVELOPMENT 13 1426 7.131e-08 1.037e-05
33 TISSUE MORPHOGENESIS 9 533 7.576e-08 1.068e-05
34 NEURON PROJECTION DEVELOPMENT 9 545 9.16e-08 1.254e-05
35 REGULATION OF CELL DIFFERENTIATION 13 1492 1.214e-07 1.614e-05
36 NEURON PROJECTION MORPHOGENESIS 8 402 1.308e-07 1.69e-05
37 MUSCLE TISSUE DEVELOPMENT 7 275 1.707e-07 2.025e-05
38 POSITIVE REGULATION OF LOCOMOTION 8 420 1.828e-07 2.025e-05
39 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 5 84 1.806e-07 2.025e-05
40 CARDIOVASCULAR SYSTEM DEVELOPMENT 10 788 1.78e-07 2.025e-05
41 CIRCULATORY SYSTEM DEVELOPMENT 10 788 1.78e-07 2.025e-05
42 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 7 274 1.665e-07 2.025e-05
43 REGULATION OF CELL SIZE 6 172 2.284e-07 2.471e-05
44 NEGATIVE REGULATION OF CELL DIFFERENTIATION 9 609 2.349e-07 2.484e-05
45 POSITIVE REGULATION OF CELL PROLIFERATION 10 814 2.404e-07 2.486e-05
46 SEMAPHORIN PLEXIN SIGNALING PATHWAY 4 36 2.686e-07 2.717e-05
47 RHYTHMIC PROCESS 7 298 2.941e-07 2.911e-05
48 CELL PART MORPHOGENESIS 9 633 3.253e-07 3.154e-05
49 STEM CELL DIFFERENTIATION 6 190 4.104e-07 3.897e-05
50 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 6 191 4.233e-07 3.939e-05
51 CENTRAL NERVOUS SYSTEM DEVELOPMENT 10 872 4.536e-07 4.139e-05
52 NEURON DEVELOPMENT 9 687 6.464e-07 5.784e-05
53 OVULATION CYCLE 5 113 7.959e-07 6.858e-05
54 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 10 926 7.866e-07 6.858e-05
55 HEAD DEVELOPMENT 9 709 8.408e-07 7.113e-05
56 FOREBRAIN DEVELOPMENT 7 357 9.899e-07 8.225e-05
57 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 10 957 1.062e-06 8.567e-05
58 RESPONSE TO ALCOHOL 7 362 1.086e-06 8.567e-05
59 REGULATION OF CELL PROLIFERATION 12 1496 1.084e-06 8.567e-05
60 NEURAL CREST CELL MIGRATION 4 51 1.121e-06 8.696e-05
61 REGULATION OF VASCULATURE DEVELOPMENT 6 233 1.353e-06 0.0001032
62 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 11 1275 1.749e-06 0.0001313
63 CARDIAC RIGHT VENTRICLE MORPHOGENESIS 3 16 1.863e-06 0.0001354
64 BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS 3 16 1.863e-06 0.0001354
65 RESPONSE TO ABIOTIC STIMULUS 10 1024 1.961e-06 0.0001404
66 MORPHOGENESIS OF AN EPITHELIUM 7 400 2.11e-06 0.0001488
67 ANATOMICAL STRUCTURE ARRANGEMENT 3 17 2.259e-06 0.0001569
68 GROWTH 7 410 2.485e-06 0.00017
69 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 144 2.637e-06 0.0001778
70 RETINAL GANGLION CELL AXON GUIDANCE 3 18 2.708e-06 0.00018
71 POSITIVE REGULATION OF CELL DIFFERENTIATION 9 823 2.885e-06 0.0001891
72 NEGATIVE REGULATION OF AXONOGENESIS 4 65 2.993e-06 0.0001934
73 CELL MOTILITY 9 835 3.249e-06 0.0001986
74 KIDNEY VASCULATURE DEVELOPMENT 3 19 3.213e-06 0.0001986
75 LOCALIZATION OF CELL 9 835 3.249e-06 0.0001986
76 RENAL SYSTEM VASCULATURE DEVELOPMENT 3 19 3.213e-06 0.0001986
77 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 11 1360 3.286e-06 0.0001986
78 RESPONSE TO DRUG 7 431 3.456e-06 0.0002062
79 MUSCLE STRUCTURE DEVELOPMENT 7 432 3.509e-06 0.0002067
80 AMEBOIDAL TYPE CELL MIGRATION 5 154 3.666e-06 0.0002132
81 REGULATION OF EPITHELIAL CELL PROLIFERATION 6 285 4.335e-06 0.000249
82 REGULATION OF DEVELOPMENTAL GROWTH 6 289 4.696e-06 0.0002665
83 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 4 74 5.037e-06 0.0002815
84 ANGIOGENESIS 6 293 5.081e-06 0.0002815
85 REGULATION OF EPITHELIAL CELL MIGRATION 5 166 5.291e-06 0.0002842
86 CELLULAR GLUCOSE HOMEOSTASIS 4 75 5.315e-06 0.0002842
87 NEURAL CREST CELL DIFFERENTIATION 4 75 5.315e-06 0.0002842
88 MORPHOGENESIS OF A BRANCHING STRUCTURE 5 167 5.449e-06 0.0002881
89 EMBRYO DEVELOPMENT 9 894 5.671e-06 0.00029
90 RESPONSE TO CARBOHYDRATE 5 168 5.61e-06 0.00029
91 REGULATION OF AXONOGENESIS 5 168 5.61e-06 0.00029
92 HEART DEVELOPMENT 7 466 5.773e-06 0.000292
93 DIENCEPHALON DEVELOPMENT 4 77 5.904e-06 0.0002954
94 VASCULATURE DEVELOPMENT 7 469 6.02e-06 0.0002964
95 CELL PROJECTION ORGANIZATION 9 902 6.097e-06 0.0002964
96 NEGATIVE REGULATION OF NEURON DEATH 5 171 6.115e-06 0.0002964
97 POSITIVE REGULATION OF CELL DEVELOPMENT 7 472 6.277e-06 0.0003011
98 RESPONSE TO ORGANIC CYCLIC COMPOUND 9 917 6.969e-06 0.0003309
99 REGULATION OF CELL DEATH 11 1472 7.061e-06 0.0003319
100 REGIONALIZATION 6 311 7.148e-06 0.0003326
101 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 8 689 7.439e-06 0.0003427
102 RESPONSE TO ACID CHEMICAL 6 319 8.263e-06 0.0003742
103 RESPONSE TO KETONE 5 182 8.282e-06 0.0003742
104 RESPONSE TO STEROID HORMONE 7 497 8.792e-06 0.0003933
105 EPITHELIUM DEVELOPMENT 9 945 8.888e-06 0.0003939
106 NEGATIVE REGULATION OF AXON GUIDANCE 3 27 9.617e-06 0.0004221
107 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 12 1848 9.912e-06 0.0004311
108 SEGMENTATION 4 89 1.052e-05 0.0004505
109 DEVELOPMENTAL GROWTH 6 333 1.055e-05 0.0004505
110 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 337 1.129e-05 0.0004734
111 REGULATION OF CELLULAR COMPONENT SIZE 6 337 1.129e-05 0.0004734
112 GLAND MORPHOGENESIS 4 97 1.479e-05 0.0006146
113 SALIVARY GLAND DEVELOPMENT 3 32 1.622e-05 0.0006621
114 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 1.622e-05 0.0006621
115 BLOOD VESSEL MORPHOGENESIS 6 364 1.748e-05 0.0006892
116 TUBE DEVELOPMENT 7 552 1.736e-05 0.0006892
117 REGULATION OF EXTENT OF CELL GROWTH 4 101 1.736e-05 0.0006892
118 REGULATION OF CELL MORPHOGENESIS 7 552 1.736e-05 0.0006892
119 NEURON RECOGNITION 3 33 1.783e-05 0.000697
120 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 4 103 1.876e-05 0.0007273
121 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 5 216 1.896e-05 0.0007291
122 POSITIVE CHEMOTAXIS 3 36 2.325e-05 0.0008869
123 NEGATIVE REGULATION OF GLIOGENESIS 3 37 2.528e-05 0.0009563
124 NEGATIVE REGULATION OF AXON EXTENSION 3 38 2.742e-05 0.001029
125 RESPONSE TO OXYGEN CONTAINING COMPOUND 10 1381 2.764e-05 0.001029
126 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 4 115 2.895e-05 0.001063
127 NEGATIVE REGULATION OF GROWTH 5 236 2.9e-05 0.001063
128 REGULATION OF AXON GUIDANCE 3 39 2.967e-05 0.00107
129 NEGATIVE REGULATION OF MITOCHONDRION ORGANIZATION 3 39 2.967e-05 0.00107
130 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 4 117 3.098e-05 0.001109
131 POSITIVE REGULATION OF CELL DEATH 7 605 3.127e-05 0.001111
132 REGULATION OF ORGAN MORPHOGENESIS 5 242 3.27e-05 0.001153
133 REPRODUCTIVE SYSTEM DEVELOPMENT 6 408 3.32e-05 0.001161
134 PATTERN SPECIFICATION PROCESS 6 418 3.801e-05 0.00132
135 CRANIAL NERVE DEVELOPMENT 3 43 3.99e-05 0.001365
136 REGULATION OF NEURON DEATH 5 252 3.967e-05 0.001365
137 REGULATION OF GROWTH 7 633 4.172e-05 0.00141
138 RESPONSE TO ENDOGENOUS STIMULUS 10 1450 4.205e-05 0.00141
139 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 8 876 4.212e-05 0.00141
140 EXOCRINE SYSTEM DEVELOPMENT 3 45 4.578e-05 0.00152
141 RESPONSE TO LIPID 8 888 4.639e-05 0.00152
142 NEGATIVE REGULATION OF CELL PROLIFERATION 7 643 4.609e-05 0.00152
143 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 6 437 4.87e-05 0.001563
144 RETINA DEVELOPMENT IN CAMERA TYPE EYE 4 131 4.822e-05 0.001563
145 CELLULAR RESPONSE TO ABIOTIC STIMULUS 5 263 4.862e-05 0.001563
146 SEX DIFFERENTIATION 5 266 5.131e-05 0.001635
147 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 4 135 5.423e-05 0.001717
148 RESPONSE TO AXON INJURY 3 48 5.563e-05 0.001737
149 DIGESTIVE TRACT MORPHOGENESIS 3 48 5.563e-05 0.001737
150 CELL PROLIFERATION 7 672 6.093e-05 0.00189
151 CELLULAR RESPONSE TO LIPID 6 457 6.243e-05 0.001924
152 EMBRYONIC ORGAN MORPHOGENESIS 5 279 6.434e-05 0.001969
153 NEGATIVE REGULATION OF CHEMOTAXIS 3 51 6.677e-05 0.00203
154 POSITIVE REGULATION OF CELL COMMUNICATION 10 1532 6.721e-05 0.002031
155 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 6 465 6.872e-05 0.002063
156 CARDIAC CHAMBER DEVELOPMENT 4 144 6.972e-05 0.002079
157 WOUND HEALING 6 470 7.29e-05 0.002161
158 RESPONSE TO ESTRADIOL 4 146 7.356e-05 0.002166
159 NEGATIVE REGULATION OF AUTOPHAGY 3 53 7.495e-05 0.00218
160 REGULATION OF ANATOMICAL STRUCTURE SIZE 6 472 7.463e-05 0.00218
161 RESPONSE TO INORGANIC SUBSTANCE 6 479 8.095e-05 0.002339
162 UROGENITAL SYSTEM DEVELOPMENT 5 299 8.921e-05 0.002562
163 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 4 154 9.047e-05 0.002582
164 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 4 156 9.51e-05 0.002682
165 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 303 9.496e-05 0.002682
166 EPITHELIAL CELL DIFFERENTIATION 6 495 9.699e-05 0.002719
167 POSITIVE REGULATION OF NEURON DIFFERENTIATION 5 306 9.947e-05 0.002771
168 REPRODUCTION 9 1297 0.000108 0.002991
169 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 0.0001087 0.002992
170 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 8 1008 0.0001131 0.003096
171 OVARIAN FOLLICLE DEVELOPMENT 3 61 0.0001142 0.003107
172 CARDIAC VENTRICLE MORPHOGENESIS 3 62 0.0001199 0.003243
173 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 4 166 0.0001209 0.003252
174 NEGATIVE REGULATION OF GLIAL CELL PROLIFERATION 2 11 0.0001268 0.00339
175 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 10 1656 0.0001294 0.003439
176 GLUCOSE HOMEOSTASIS 4 170 0.0001325 0.003484
177 CARBOHYDRATE HOMEOSTASIS 4 170 0.0001325 0.003484
178 CELL CELL SIGNALING 7 767 0.0001394 0.003645
179 MULTICELLULAR ORGANISM REPRODUCTION 7 768 0.0001406 0.003654
180 REGULATION OF CELL SUBSTRATE ADHESION 4 173 0.0001418 0.003665
181 NEURON PROJECTION EXTENSION INVOLVED IN NEURON PROJECTION GUIDANCE 2 12 0.000152 0.003864
182 AXON EXTENSION INVOLVED IN AXON GUIDANCE 2 12 0.000152 0.003864
183 HEART FORMATION 2 12 0.000152 0.003864
184 MULTICELLULAR ORGANISMAL RESPONSE TO STRESS 3 68 0.0001578 0.003948
185 ORGAN GROWTH 3 68 0.0001578 0.003948
186 NERVE DEVELOPMENT 3 68 0.0001578 0.003948
187 REGULATION OF CHEMOTAXIS 4 180 0.0001651 0.004108
188 REGULATION OF MEMBRANE POTENTIAL 5 343 0.0001697 0.004199
189 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 3 70 0.000172 0.004235
190 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 7 799 0.0001796 0.004307
191 CELLULAR RESPONSE TO THYROID HORMONE STIMULUS 2 13 0.0001794 0.004307
192 SEMAPHORIN PLEXIN SIGNALING PATHWAY INVOLVED IN NEURON PROJECTION GUIDANCE 2 13 0.0001794 0.004307
193 MESENCHYMAL CELL PROLIFERATION 2 13 0.0001794 0.004307
194 GANGLION DEVELOPMENT 2 13 0.0001794 0.004307
195 SPECIFICATION OF ORGAN IDENTITY 2 14 0.0002091 0.00494
196 ATRIAL SEPTUM MORPHOGENESIS 2 14 0.0002091 0.00494
197 RESPONSE TO NUTRIENT 4 191 0.0002073 0.00494
198 REGULATION OF NEURON APOPTOTIC PROCESS 4 192 0.0002114 0.004969
199 DEVELOPMENTAL CELL GROWTH 3 77 0.0002282 0.005336
200 RESPIRATORY SYSTEM DEVELOPMENT 4 197 0.0002333 0.005427
201 BLASTODERM SEGMENTATION 2 15 0.0002411 0.005553
202 REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS 2 15 0.0002411 0.005553
203 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 4 199 0.0002424 0.005557
204 DENDRITE DEVELOPMENT 3 79 0.0002462 0.005615
205 NEGATIVE REGULATION OF VASCULATURE DEVELOPMENT 3 80 0.0002555 0.0058
206 NEGATIVE REGULATION OF CATABOLIC PROCESS 4 203 0.0002615 0.005908
207 REGULATION OF RESPONSE TO STRESS 9 1468 0.0002766 0.006217
208 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 6 602 0.000281 0.006286
209 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 8 1152 0.0002837 0.006317
210 LIPID MODIFICATION 4 210 0.0002976 0.006593
211 CARDIAC SEPTUM DEVELOPMENT 3 85 0.0003056 0.006714
212 NEGATIVE REGULATION OF STEM CELL PROLIFERATION 2 17 0.0003117 0.006714
213 HEART MORPHOGENESIS 4 212 0.0003085 0.006714
214 REGULATION OF CELL GROWTH 5 391 0.0003111 0.006714
215 NEGATIVE REGULATION OF CELL DEATH 7 872 0.0003068 0.006714
216 PARASYMPATHETIC NERVOUS SYSTEM DEVELOPMENT 2 17 0.0003117 0.006714
217 OVULATION CYCLE PROCESS 3 88 0.0003384 0.007257
218 RESPONSE TO ESTROGEN 4 218 0.000343 0.007287
219 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 4 218 0.000343 0.007287
220 ATRIAL SEPTUM DEVELOPMENT 2 18 0.0003503 0.007375
221 KIDNEY MESENCHYME DEVELOPMENT 2 18 0.0003503 0.007375
222 RESPONSE TO HORMONE 7 893 0.0003546 0.007416
223 REGULATION OF CELL ADHESION 6 629 0.0003554 0.007416
224 NEGATIVE REGULATION OF CELL COMMUNICATION 8 1192 0.0003576 0.007429
225 ENDOTHELIUM DEVELOPMENT 3 90 0.0003616 0.007444
226 REGULATION OF GLIOGENESIS 3 90 0.0003616 0.007444
227 EMBRYONIC ORGAN DEVELOPMENT 5 406 0.0003698 0.00758
228 NEGATIVE REGULATION OF NUCLEOSIDE METABOLIC PROCESS 2 19 0.0003911 0.007947
229 NEGATIVE REGULATION OF ATP METABOLIC PROCESS 2 19 0.0003911 0.007947
230 CELL FATE COMMITMENT 4 227 0.0003997 0.008087
231 TELENCEPHALON DEVELOPMENT 4 228 0.0004064 0.008187
232 AXONAL FASCICULATION 2 20 0.0004342 0.00867
233 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 4 232 0.000434 0.00867
234 POSITIVE REGULATION OF RESPONSE TO STIMULUS 10 1929 0.000452 0.008988
235 RESPONSE TO VITAMIN 3 98 0.0004642 0.009191
236 MUSCLE CELL DIFFERENTIATION 4 237 0.0004704 0.009275
237 REGULATION OF GLIAL CELL PROLIFERATION 2 21 0.0004794 0.009333
238 REGULATION OF ERK1 AND ERK2 CASCADE 4 238 0.0004779 0.009333
239 SYMPATHETIC NERVOUS SYSTEM DEVELOPMENT 2 21 0.0004794 0.009333
240 SENSORY ORGAN MORPHOGENESIS 4 239 0.0004855 0.009413
241 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 100 0.0004925 0.009508
NumGOOverlapSizeP ValueAdj. P Value
1 RECEPTOR BINDING 13 1476 1.07e-07 9.937e-05
2 HEPARIN BINDING 5 157 4.029e-06 0.001872
3 GLYCOSAMINOGLYCAN BINDING 5 205 1.474e-05 0.004564
4 SULFUR COMPOUND BINDING 5 234 2.784e-05 0.006467
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR SPACE 12 1376 4.428e-07 0.0002586
2 PROTEINACEOUS EXTRACELLULAR MATRIX 6 356 1.541e-05 0.004501
3 EXTRACELLULAR MATRIX 6 426 4.225e-05 0.008225

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 PI3K_Akt_signaling_pathway_hsa04151 5 352 0.0001914 0.009952
2 Ras_signaling_pathway_hsa04014 4 232 0.000434 0.01129
3 Autophagy_animal_hsa04140 3 128 0.00101 0.0175
4 Wnt_signaling_pathway_hsa04310 3 146 0.001475 0.01917
5 Cellular_senescence_hsa04218 3 160 0.001916 0.01993
6 Focal_adhesion_hsa04510 3 199 0.003552 0.02614
7 Rap1_signaling_pathway_hsa04015 3 206 0.003914 0.02614
8 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.004021 0.02614
9 Mitophagy_animal_hsa04137 2 65 0.004551 0.0263
10 MAPK_signaling_pathway_hsa04010 3 295 0.01052 0.05472
11 Sphingolipid_signaling_pathway_hsa04071 2 118 0.01435 0.06786
12 Apelin_signaling_pathway_hsa04371 2 137 0.01902 0.07819
13 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.01955 0.07819
14 Cell_adhesion_molecules_.CAMs._hsa04514 2 145 0.02116 0.07858
15 Tight_junction_hsa04530 2 170 0.02842 0.09854
16 cAMP_signaling_pathway_hsa04024 2 198 0.03758 0.1221

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 RP11-815I9.4 hsa-miR-130a-3p;hsa-miR-148a-3p;hsa-miR-186-5p;hsa-miR-214-3p;hsa-miR-30a-5p;hsa-miR-30c-5p;hsa-miR-320a;hsa-miR-324-5p;hsa-miR-590-5p;hsa-miR-664a-3p 10 NRP1 Sponge network -0.348 0.02944 0.111 0.41779 0.39
2 OIP5-AS1 hsa-miR-130a-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-186-5p;hsa-miR-214-3p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-320a;hsa-miR-324-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-664a-3p 14 NRP1 Sponge network -0.421 0 0.111 0.41779 0.389
3 BHLHE40-AS1 hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-148a-3p;hsa-miR-186-5p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30e-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p 11 NRP1 Sponge network -0.37 0.02438 0.111 0.41779 0.36
4 SNHG14 hsa-miR-130a-3p;hsa-miR-186-5p;hsa-miR-214-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-324-5p;hsa-miR-361-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-664a-3p 12 NRP1 Sponge network -0.051 0.64448 0.111 0.41779 0.268

Quest ID: 0993bf6231fa498a4eff798110354409