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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-342-3p AADAC 1.22 0 -4.47 0 miRanda -0.67 0 NA
2 hsa-miR-27a-5p ABAT -1.24 0 0.64 0.00201 miRNATAP -0.31 0 NA
3 hsa-miR-342-3p ABCA13 1.22 0 -1.78 0 miRanda -0.5 0 NA
4 hsa-miR-342-3p ABCA6 1.22 0 -3.37 0 miRanda -0.3 0 NA
5 hsa-miR-342-3p ABCC9 1.22 0 -2.42 0 miRanda -0.26 0 NA
6 hsa-miR-214-3p ABHD2 -0.52 0.00021 0.45 0.00053 miRNATAP -0.12 0.00013 NA
7 hsa-miR-24-2-5p ACADSB -0.22 0.05957 -0.52 0.002 MirTarget -0.41 0 NA
8 hsa-miR-532-3p ACBD4 -0.4 0.00687 -0.42 0.00049 miRNATAP -0.3 0 NA
9 hsa-miR-342-3p ACER3 1.22 0 -0.64 0 miRanda -0.1 0.00023 NA
10 hsa-miR-214-3p ACLY -0.52 0.00021 0.43 0 MirTarget -0.13 0 NA
11 hsa-miR-342-3p ACSL4 1.22 0 -1.48 0 MirTarget; miRanda -0.26 0 NA
12 hsa-miR-532-3p ACVR1B -0.4 0.00687 0.15 0.02139 PITA; miRNATAP -0.11 0 NA
13 hsa-miR-342-3p ACVRL1 1.22 0 -0.99 0 miRanda -0.16 0 NA
14 hsa-miR-342-3p ADAM9 1.22 0 -0.03 0.77501 miRanda -0.14 0 NA
15 hsa-miR-342-3p ADAMTS1 1.22 0 -2.52 0 miRanda -0.41 0 NA
16 hsa-miR-532-3p ADAMTS13 -0.4 0.00687 0.49 0.00058 miRNATAP -0.3 0 NA
17 hsa-miR-143-5p ADAMTS8 -1.09 0 -1.48 0 MirTarget -0.14 0.0026 NA
18 hsa-miR-342-3p ADARB1 1.22 0 -0.6 0 miRanda -0.13 0 NA
19 hsa-miR-214-3p ADCY1 -0.52 0.00021 -0.05 0.84149 mirMAP -0.12 0.03717 NA
20 hsa-miR-342-3p ADCY2 1.22 0 -0.73 0.00385 miRanda -0.39 0 NA
21 hsa-miR-342-3p ADCY3 1.22 0 -0.58 0 miRanda -0.14 0 NA
22 hsa-miR-532-3p ADCY6 -0.4 0.00687 -0.63 0 PITA -0.17 0 NA
23 hsa-miR-342-3p ADH1B 1.22 0 -7.23 0 miRanda -0.54 2.0E-5 NA
24 hsa-miR-342-3p ADI1 1.22 0 -0.35 3.0E-5 miRanda -0.14 0 NA
25 hsa-miR-214-3p ADM2 -0.52 0.00021 2.41 0 mirMAP -0.2 0 NA
26 hsa-miR-342-3p ADORA2B 1.22 0 -0.76 0 miRanda -0.34 0 NA
27 hsa-miR-342-3p ADRA1A 1.22 0 -4.75 0 miRanda -0.46 0 NA
28 hsa-miR-342-3p ADRA2B 1.22 0 -1.36 0 miRanda -0.24 0 NA
29 hsa-miR-342-3p ADRB1 1.22 0 -2.83 0 PITA; miRanda -0.29 2.0E-5 NA
30 hsa-miR-342-3p AFF2 1.22 0 -1.78 0 mirMAP -0.32 0 NA
31 hsa-miR-342-3p AGAP11 1.22 0 -2.72 0 miRanda -0.12 0.00734 NA
32 hsa-miR-193a-5p AGAP3 -1.15 0 0.28 0.00021 miRNATAP -0.11 8.0E-5 NA
33 hsa-miR-214-3p AGPAT3 -0.52 0.00021 0.34 0 mirMAP -0.11 0 NA
34 hsa-miR-342-3p AGPAT4 1.22 0 -0.74 0 MirTarget -0.32 0 NA
35 hsa-miR-342-3p AIFM2 1.22 0 -1.44 0 miRanda -0.15 0 NA
36 hsa-miR-342-3p AK5 1.22 0 -3.09 0 miRanda -0.19 0.00828 NA
37 hsa-miR-342-3p AKAP7 1.22 0 -1.02 0 miRanda -0.13 0 NA
38 hsa-miR-342-3p AKR1B1 1.22 0 -0.51 0 miRanda -0.18 0 NA
39 hsa-miR-532-3p ALCAM -0.4 0.00687 0.51 0.00106 MirTarget; PITA; miRNATAP -0.21 0 NA
40 hsa-miR-342-3p ALS2CL 1.22 0 -1.15 0 mirMAP -0.21 0 NA
41 hsa-miR-342-3p ALS2CR11 1.22 0 -1.63 0 miRanda -0.13 0.00564 NA
42 hsa-miR-342-3p ALX4 1.22 0 -3.22 0 mirMAP -0.43 0 NA
43 hsa-miR-532-3p AMDHD2 -0.4 0.00687 0.93 0 mirMAP -0.24 0 NA
44 hsa-miR-342-3p AMOT 1.22 0 -0.91 0 miRanda -0.13 3.0E-5 NA
45 hsa-miR-342-3p ANGPTL1 1.22 0 -3.72 0 miRanda -0.33 0 NA
46 hsa-miR-342-3p ANGPTL2 1.22 0 -1.92 0 miRanda -0.31 0 NA
47 hsa-miR-342-3p ANGPTL4 1.22 0 -2.45 0 miRanda -0.52 0 NA
48 hsa-miR-342-3p ANK2 1.22 0 -2.51 0 miRanda; miRNATAP -0.28 0 NA
49 hsa-miR-342-3p ANKDD1A 1.22 0 -1.5 0 miRanda -0.15 0 NA
50 hsa-miR-214-3p ANKRD23 -0.52 0.00021 0.4 7.0E-5 mirMAP -0.1 3.0E-5 NA
51 hsa-miR-214-3p ANKRD52 -0.52 0.00021 0.23 0.00024 miRNATAP -0.11 0 NA
52 hsa-miR-214-3p ANKS1B -0.52 0.00021 0.2 0.2194 miRNATAP -0.21 0 NA
53 hsa-miR-342-3p ANTXR1 1.22 0 -0.18 0.16983 miRanda -0.13 2.0E-5 NA
54 hsa-miR-342-3p ANXA8 1.22 0 -2.01 0 MirTarget; miRanda -0.61 0 NA
55 hsa-miR-342-3p APOLD1 1.22 0 -1.8 0 MirTarget; miRanda -0.17 0 NA
56 hsa-miR-342-3p AQP4 1.22 0 -2.95 0 miRanda -0.35 0 NA
57 hsa-miR-342-3p ARAP3 1.22 0 -1.27 0 mirMAP -0.23 0 NA
58 hsa-miR-532-3p ARFIP2 -0.4 0.00687 0.83 0 PITA -0.2 0 NA
59 hsa-miR-342-3p ARHGAP21 1.22 0 -1.05 0 miRanda -0.19 0 NA
60 hsa-miR-342-3p ARHGAP26 1.22 0 -1.51 0 mirMAP -0.16 0 NA
61 hsa-miR-532-3p ARHGAP6 -0.4 0.00687 -1.65 0 PITA -0.16 0 NA
62 hsa-miR-342-3p ARHGEF9 1.22 0 -0.44 0 miRanda -0.1 0 NA
63 hsa-miR-342-3p ARID5B 1.22 0 -1.75 0 PITA; miRanda -0.16 0 NA
64 hsa-miR-342-3p ARL10 1.22 0 -1.27 0 mirMAP -0.25 0 NA
65 hsa-miR-532-3p ARL3 -0.4 0.00687 0.59 0 PITA -0.13 0 NA
66 hsa-miR-342-3p ASB1 1.22 0 -0.93 0 mirMAP -0.12 0 NA
67 hsa-miR-214-3p ASF1B -0.52 0.00021 3.18 0 miRNAWalker2 validate -0.24 0 NA
68 hsa-miR-342-3p ASTN1 1.22 0 -2.96 0 miRanda -0.35 0 NA
69 hsa-miR-342-3p ATF3 1.22 0 -2.25 0 miRanda -0.28 0 NA
70 hsa-miR-342-3p ATP10B 1.22 0 -1.05 8.0E-5 miRanda -0.46 0 NA
71 hsa-miR-342-3p ATP11A 1.22 0 -0.67 0 miRanda -0.21 0 NA
72 hsa-miR-532-3p ATP1A2 -0.4 0.00687 -5.48 0 MirTarget -0.51 0 NA
73 hsa-miR-214-3p ATP2A3 -0.52 0.00021 1.22 0 MirTarget -0.14 0.00049 NA
74 hsa-miR-342-3p ATP2B4 1.22 0 -1.11 0 mirMAP -0.13 0 NA
75 hsa-miR-574-3p ATPIF1 -0.8 0 1.07 0 PITA -0.23 0 NA
76 hsa-miR-342-3p ATXN1L 1.22 0 -0.97 0 miRNATAP -0.14 0 NA
77 hsa-miR-143-5p B3GAT3 -1.09 0 1.08 0 miRNATAP -0.16 0 NA
78 hsa-miR-342-3p B3GNT3 1.22 0 -1.39 0 miRanda -0.55 0 NA
79 hsa-miR-342-3p B3GNT7 1.22 0 0.2 0.16025 MirTarget; miRanda -0.23 0 NA
80 hsa-miR-342-3p B4GALT5 1.22 0 -0.34 4.0E-5 mirMAP -0.11 0 NA
81 hsa-miR-342-3p BAG2 1.22 0 -0.04 0.72195 miRanda -0.2 0 NA
82 hsa-miR-214-5p BATF2 0.05 0.67611 0.32 0.07164 MirTarget -0.18 0.00043 NA
83 hsa-miR-214-3p BAZ2A -0.52 0.00021 -0.1 0.10091 MirTarget; miRNATAP -0.11 0 NA
84 hsa-miR-532-3p BBC3 -0.4 0.00687 1.65 0 PITA; miRNATAP -0.35 0 NA
85 hsa-miR-342-3p BBOX1 1.22 0 -3.62 0 miRanda -0.84 0 NA
86 hsa-miR-342-3p BCL11A 1.22 0 -1.42 0 miRanda -0.55 0 NA
87 hsa-miR-193a-5p BCL11B -1.15 0 -0.26 0.19747 PITA; TargetScan; miRNATAP -0.18 0.01362 NA
88 hsa-miR-24-2-5p BCL2 -0.22 0.05957 -0.9 0 miRNAWalker2 validate; miRTarBase -0.31 0 NA
89 hsa-miR-193a-5p BCL7C -1.15 0 0.83 0 PITA; TargetScan -0.23 0 NA
90 hsa-miR-210-3p BDNF 2.38 0 -1.6 0 miRNAWalker2 validate; miRTarBase -0.12 7.0E-5 NA
91 hsa-miR-342-3p BHLHE41 1.22 0 -1.53 0 miRanda -0.2 0 NA
92 hsa-miR-193a-5p BMF -1.15 0 0.83 0 TargetScan; miRNATAP -0.18 0 NA
93 hsa-miR-342-3p BMP7 1.22 0 -0.57 0.0198 miRNAWalker2 validate; miRTarBase; miRanda -0.4 0 NA
94 hsa-miR-342-3p BNC1 1.22 0 -2.84 0 miRanda -0.45 0 NA
95 hsa-miR-214-3p BRSK2 -0.52 0.00021 1.86 0 mirMAP -0.22 0.00189 NA
96 hsa-miR-214-3p BSN -0.52 0.00021 -0.24 0.13233 mirMAP -0.15 0.00013 NA
97 hsa-miR-143-5p BSPRY -1.09 0 1.6 0 MirTarget -0.17 0 NA
98 hsa-miR-342-3p BTG3 1.22 0 -0.4 0.00167 miRanda -0.25 0 NA
99 hsa-miR-342-3p C10orf10 1.22 0 -2.19 0 mirMAP -0.38 0 NA
100 hsa-miR-532-3p C16orf58 -0.4 0.00687 0.72 0 miRNATAP -0.12 0 NA
101 hsa-miR-214-3p C16orf59 -0.52 0.00021 3.18 0 mirMAP -0.22 0 NA
102 hsa-miR-342-3p C17orf51 1.22 0 -1.38 0 mirMAP -0.37 0 NA
103 hsa-miR-342-3p C1orf115 1.22 0 -1.55 0 mirMAP -0.15 8.0E-5 NA
104 hsa-miR-342-3p C1orf198 1.22 0 -0.18 0.02916 mirMAP -0.15 0 NA
105 hsa-miR-532-3p C3orf18 -0.4 0.00687 -0.47 7.0E-5 miRNATAP -0.27 0 NA
106 hsa-miR-342-3p C3orf70 1.22 0 -0.82 0 mirMAP -0.15 1.0E-5 NA
107 hsa-miR-342-3p C6orf223 1.22 0 1.13 0.00032 mirMAP -0.28 0.00023 NA
108 hsa-miR-342-3p CACNA1C 1.22 0 -0.83 0 MirTarget; PITA; miRanda; miRNATAP -0.12 0.00028 NA
109 hsa-miR-532-3p CACNA1I -0.4 0.00687 0.62 0.00607 mirMAP -0.12 0.01951 NA
110 hsa-miR-342-3p CADM3 1.22 0 -3.48 0 miRanda -0.35 0 NA
111 hsa-miR-532-3p CADM3 -0.4 0.00687 -3.48 0 MirTarget -0.29 4.0E-5 NA
112 hsa-miR-342-3p CAMK2D 1.22 0 -0.88 0 miRanda -0.13 0 NA
113 hsa-miR-214-3p CAPRIN1 -0.52 0.00021 0.34 0 MirTarget -0.11 0 NA
114 hsa-miR-214-3p CARTPT -0.52 0.00021 0.49 0.2615 MirTarget -0.41 0.00011 NA
115 hsa-miR-214-3p CASKIN1 -0.52 0.00021 2.05 0 miRNATAP -0.25 0 NA
116 hsa-miR-342-3p CAV1 1.22 0 -3.35 0 miRanda -0.37 0 NA
117 hsa-miR-342-3p CBX2 1.22 0 1.77 0 mirMAP -0.17 0.00048 NA
118 hsa-miR-342-3p CCDC141 1.22 0 -2.66 0 miRanda -0.21 0 NA
119 hsa-miR-342-3p CCDC68 1.22 0 -2.06 0 miRanda -0.11 0.04166 NA
120 hsa-miR-532-3p CCDC68 -0.4 0.00687 -2.06 0 MirTarget -0.25 0 NA
121 hsa-miR-342-3p CCL8 1.22 0 -1.17 0 miRanda -0.17 0.00081 NA
122 hsa-miR-214-5p CCND1 0.05 0.67611 0.79 0 MirTarget -0.11 0.01381 NA
123 hsa-miR-342-3p CCND2 1.22 0 -1.32 0 miRNAWalker2 validate; mirMAP -0.1 0.00019 NA
124 hsa-miR-193a-5p CCNL2 -1.15 0 -0.08 0.37557 PITA -0.1 0.00085 NA
125 hsa-miR-193a-5p CCT3 -1.15 0 1.21 0 miRNATAP -0.12 1.0E-5 NA
126 hsa-miR-342-3p CD109 1.22 0 -0.52 0.00083 mirMAP -0.18 0 NA
127 hsa-miR-193a-5p CD247 -1.15 0 -0.08 0.66708 miRNATAP -0.17 0.01089 NA
128 hsa-miR-342-3p CD302 1.22 0 -1.77 0 miRanda -0.12 4.0E-5 NA
129 hsa-miR-342-3p CD55 1.22 0 -0.36 0.00102 miRanda -0.18 0 NA
130 hsa-miR-342-3p CDH13 1.22 0 -1.59 0 miRanda -0.19 0 NA
131 hsa-miR-342-3p CDH23 1.22 0 -2.27 0 PITA -0.35 0 NA
132 hsa-miR-532-3p CDH23 -0.4 0.00687 -2.27 0 mirMAP -0.19 0 NA
133 hsa-miR-342-3p CDH8 1.22 0 -1.56 0 miRanda -0.18 0.00034 NA
134 hsa-miR-214-3p CECR6 -0.52 0.00021 0.08 0.58303 mirMAP -0.1 0.00358 NA
135 hsa-miR-342-3p CELF2 1.22 0 -2.12 0 miRanda -0.22 0 NA
136 hsa-miR-342-3p CELF4 1.22 0 -0.14 0.49289 miRanda -0.13 0.00668 NA
137 hsa-miR-193a-5p CELF5 -1.15 0 -0.96 0.00036 miRNATAP -0.3 0.00195 NA
138 hsa-miR-214-3p CELSR1 -0.52 0.00021 1.62 0 mirMAP -0.19 1.0E-5 NA
139 hsa-miR-214-3p CELSR2 -0.52 0.00021 0.81 0 MirTarget; miRNATAP -0.25 0 NA
140 hsa-miR-193a-5p CELSR3 -1.15 0 2.04 0 PITA -0.16 0.01897 NA
141 hsa-miR-214-3p CENPO -0.52 0.00021 1.2 0 miRNATAP -0.13 0 NA
142 hsa-miR-193a-5p CENPP -1.15 0 1.39 0 mirMAP -0.37 0 NA
143 hsa-miR-342-3p CENPV 1.22 0 -0.6 0.00178 miRanda -0.19 4.0E-5 NA
144 hsa-miR-342-3p CFL2 1.22 0 -1.91 0 PITA; miRanda -0.18 0 NA
145 hsa-miR-532-3p CGNL1 -0.4 0.00687 -0.82 0 MirTarget -0.16 0 NA
146 hsa-miR-342-3p CGREF1 1.22 0 0.6 0.00031 miRanda -0.14 0.00068 NA
147 hsa-miR-342-3p CHD5 1.22 0 -0.23 0.28718 mirMAP -0.11 0.04072 NA
148 hsa-miR-193a-5p CHERP -1.15 0 0.51 0 TargetScan -0.13 0 NA
149 hsa-miR-342-3p CHL1 1.22 0 -4.19 0 miRanda -0.42 0 NA
150 hsa-miR-342-3p CHODL 1.22 0 -2.01 0 miRanda -0.53 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 NEUROGENESIS 145 1402 7.478e-21 3.48e-17
2 REGULATION OF CELL DIFFERENTIATION 135 1492 1.286e-14 1.995e-11
3 CELL DEVELOPMENT 131 1426 1.076e-14 1.995e-11
4 NEURON DIFFERENTIATION 93 874 2.791e-14 3.247e-11
5 POSITIVE REGULATION OF NEURON DIFFERENTIATION 46 306 1.27e-12 1.182e-09
6 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 140 1672 1.566e-12 1.214e-09
7 NEURON DEVELOPMENT 75 687 2.96e-12 1.968e-09
8 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 62 513 3.424e-12 1.992e-09
9 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 114 1275 4.284e-12 2.215e-09
10 POSITIVE REGULATION OF CELL DIFFERENTIATION 84 823 5.06e-12 2.354e-09
11 REGULATION OF NEURON DIFFERENTIATION 63 554 3.184e-11 1.329e-08
12 CELLULAR COMPONENT MORPHOGENESIS 87 900 3.714e-11 1.329e-08
13 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 37 232 3.563e-11 1.329e-08
14 NEURON PROJECTION MORPHOGENESIS 51 402 5.143e-11 1.709e-08
15 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 48 368 7.287e-11 2.261e-08
16 LOCOMOTION 100 1114 8.265e-11 2.404e-08
17 POSITIVE REGULATION OF CELL COMMUNICATION 125 1532 1.619e-10 4.432e-08
18 POSITIVE REGULATION OF CELL DEVELOPMENT 55 472 2.369e-10 6.123e-08
19 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 88 957 3.741e-10 7.568e-08
20 NEURON PROJECTION DEVELOPMENT 60 545 3.48e-10 7.568e-08
21 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 100 1142 3.28e-10 7.568e-08
22 BEHAVIOR 58 516 3.106e-10 7.568e-08
23 TISSUE DEVELOPMENT 123 1518 3.591e-10 7.568e-08
24 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 115 1395 5.293e-10 1.026e-07
25 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 138 1784 5.987e-10 1.114e-07
26 REGULATION OF GROWTH 65 633 1.144e-09 2.048e-07
27 ORGAN MORPHOGENESIS 79 841 1.194e-09 2.058e-07
28 BLOOD VESSEL MORPHOGENESIS 45 364 1.636e-09 2.719e-07
29 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 40 303 1.984e-09 3.183e-07
30 REGULATION OF CELL DEVELOPMENT 78 836 2.08e-09 3.226e-07
31 REGULATION OF CELL PROLIFERATION 119 1496 2.182e-09 3.275e-07
32 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 50 437 2.935e-09 4.267e-07
33 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 80 876 3.409e-09 4.806e-07
34 CARDIOVASCULAR SYSTEM DEVELOPMENT 74 788 4.17e-09 5.544e-07
35 CIRCULATORY SYSTEM DEVELOPMENT 74 788 4.17e-09 5.544e-07
36 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 71 750 6.26e-09 8.091e-07
37 REGULATION OF MEMBRANE POTENTIAL 42 343 7.625e-09 9.589e-07
38 SKELETAL SYSTEM DEVELOPMENT 50 455 1.126e-08 1.378e-06
39 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 125 1656 1.874e-08 2.236e-06
40 NEURON PROJECTION GUIDANCE 30 205 1.977e-08 2.299e-06
41 SENSORY ORGAN DEVELOPMENT 52 493 2.269e-08 2.575e-06
42 POSITIVE REGULATION OF RESPONSE TO STIMULUS 140 1929 2.714e-08 2.937e-06
43 CELL PROJECTION ORGANIZATION 79 902 2.697e-08 2.937e-06
44 VASCULATURE DEVELOPMENT 50 469 3.012e-08 3.185e-06
45 REGULATION OF NEURON PROJECTION DEVELOPMENT 45 408 5.486e-08 5.673e-06
46 BIOLOGICAL ADHESION 86 1032 6.071e-08 6.141e-06
47 ANGIOGENESIS 36 293 8.212e-08 8.13e-06
48 REGULATION OF CELLULAR COMPONENT MOVEMENT 69 771 9.417e-08 9.129e-06
49 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 25 162 1.04e-07 9.873e-06
50 MUSCLE STRUCTURE DEVELOPMENT 46 432 1.118e-07 1.04e-05
51 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 85 1036 1.434e-07 1.283e-05
52 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 85 1036 1.434e-07 1.283e-05
53 CELL CELL SIGNALING 68 767 1.666e-07 1.436e-05
54 EMBRYONIC MORPHOGENESIS 53 539 1.666e-07 1.436e-05
55 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 104 1360 1.818e-07 1.538e-05
56 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 24 156 1.976e-07 1.642e-05
57 CELL PART MORPHOGENESIS 59 633 2.122e-07 1.732e-05
58 POSITIVE REGULATION OF MOLECULAR FUNCTION 128 1791 2.784e-07 2.233e-05
59 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 83 1021 2.987e-07 2.265e-05
60 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 82 1004 2.917e-07 2.265e-05
61 NEGATIVE REGULATION OF CELL DIFFERENTIATION 57 609 2.982e-07 2.265e-05
62 NEGATIVE REGULATION OF NEURON DEATH 25 171 3.018e-07 2.265e-05
63 REGULATION OF PHOSPHORUS METABOLIC PROCESS 118 1618 3.098e-07 2.288e-05
64 EMBRYO DEVELOPMENT 75 894 3.439e-07 2.5e-05
65 POSITIVE REGULATION OF AXONOGENESIS 15 69 4.304e-07 3.081e-05
66 MODULATION OF SYNAPTIC TRANSMISSION 35 301 4.736e-07 3.339e-05
67 SINGLE ORGANISM BEHAVIOR 41 384 5.083e-07 3.53e-05
68 POSITIVE REGULATION OF GROWTH 30 238 5.639e-07 3.858e-05
69 SKELETAL SYSTEM MORPHOGENESIS 27 201 5.836e-07 3.935e-05
70 INTRACELLULAR SIGNAL TRANSDUCTION 114 1572 6.682e-07 4.441e-05
71 REGULATION OF ACTION POTENTIAL 11 38 7.053e-07 4.622e-05
72 EPITHELIUM DEVELOPMENT 77 945 7.495e-07 4.777e-05
73 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 68 799 7.432e-07 4.777e-05
74 REGULATION OF CELL GROWTH 41 391 8.159e-07 4.999e-05
75 TUBE DEVELOPMENT 52 552 8.165e-07 4.999e-05
76 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 68 801 8.127e-07 4.999e-05
77 REGULATION OF MAPK CASCADE 59 660 8.528e-07 5.153e-05
78 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 89 1152 9.824e-07 5.86e-05
79 REGULATION OF LIPASE ACTIVITY 16 83 1.006e-06 5.926e-05
80 POSITIVE REGULATION OF KINASE ACTIVITY 47 482 1.059e-06 6.159e-05
81 EAR DEVELOPMENT 26 195 1.085e-06 6.234e-05
82 POSITIVE REGULATION OF CATALYTIC ACTIVITY 110 1518 1.114e-06 6.32e-05
83 POSITIVE REGULATION OF CELL GROWTH 22 148 1.15e-06 6.447e-05
84 SKIN DEVELOPMENT 27 211 1.529e-06 8.47e-05
85 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 87 1135 1.806e-06 9.887e-05
86 REGULATION OF SYSTEM PROCESS 48 507 1.88e-06 0.0001017
87 REGULATION OF CARDIAC MUSCLE CELL CONTRACTION 9 27 1.964e-06 0.0001051
88 REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 12 50 2.012e-06 0.0001064
89 REGULATION OF KINASE ACTIVITY 65 776 2.252e-06 0.0001177
90 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 127 1848 2.442e-06 0.0001262
91 NEGATIVE REGULATION OF GENE EXPRESSION 107 1493 2.632e-06 0.0001346
92 POSITIVE REGULATION OF CELL PROLIFERATION 67 814 2.857e-06 0.0001445
93 POSITIVE REGULATION OF MAPK CASCADE 45 470 2.921e-06 0.0001446
94 REGULATION OF PROTEIN MODIFICATION PROCESS 119 1710 2.903e-06 0.0001446
95 APPENDAGE DEVELOPMENT 23 169 3.14e-06 0.0001522
96 LIMB DEVELOPMENT 23 169 3.14e-06 0.0001522
97 REGULATION OF TRANSPORT 124 1804 3.237e-06 0.0001553
98 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 77 983 3.319e-06 0.0001576
99 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 62 740 3.842e-06 0.0001806
100 CENTRAL NERVOUS SYSTEM DEVELOPMENT 70 872 4.087e-06 0.0001883
101 REGULATION OF CELL MORPHOGENESIS 50 552 4.068e-06 0.0001883
102 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 106 1492 4.35e-06 0.0001985
103 COGNITION 29 251 5.075e-06 0.0002293
104 REGULATION OF HEART RATE BY CARDIAC CONDUCTION 9 30 5.294e-06 0.0002368
105 REGULATION OF NEURON DEATH 29 252 5.489e-06 0.0002433
106 REGULATION OF PHOSPHOLIPASE ACTIVITY 13 64 5.628e-06 0.0002471
107 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 35 337 6.363e-06 0.000274
108 RESPONSE TO OXYGEN CONTAINING COMPOUND 99 1381 6.373e-06 0.000274
109 REGULATION OF BLOOD CIRCULATION 32 295 6.42e-06 0.000274
110 NEGATIVE REGULATION OF CELL COMMUNICATION 88 1192 7.042e-06 0.0002979
111 REGULATION OF HEART RATE 15 86 7.969e-06 0.0003341
112 RESPONSE TO EXTERNAL STIMULUS 123 1821 8.294e-06 0.0003446
113 CHEMICAL HOMEOSTASIS 69 874 8.404e-06 0.0003461
114 UROGENITAL SYSTEM DEVELOPMENT 32 299 8.49e-06 0.0003465
115 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 122 1805 8.791e-06 0.0003557
116 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 106 1517 9.008e-06 0.0003582
117 POSITIVE REGULATION OF GENE EXPRESSION 118 1733 8.968e-06 0.0003582
118 REGULATION OF ACTIN FILAMENT BASED MOVEMENT 9 32 9.551e-06 0.0003766
119 REGULATION OF HYDROLASE ACTIVITY 95 1327 1.05e-05 0.0004105
120 SYNAPSE ORGANIZATION 20 145 1.108e-05 0.000426
121 REGULATION OF DEVELOPMENTAL GROWTH 31 289 1.117e-05 0.000426
122 REGULATION OF HEART CONTRACTION 26 221 1.116e-05 0.000426
123 REGULATION OF CELL PROJECTION ORGANIZATION 49 558 1.174e-05 0.000444
124 CELL MOTILITY 66 835 1.275e-05 0.0004745
125 LOCALIZATION OF CELL 66 835 1.275e-05 0.0004745
126 REGULATION OF CARDIAC MUSCLE CELL ACTION POTENTIAL 7 19 1.319e-05 0.0004873
127 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 19 135 1.362e-05 0.0004953
128 CELLULAR RESPONSE TO EXTERNAL STIMULUS 29 264 1.353e-05 0.0004953
129 REGULATION OF TRANSPORTER ACTIVITY 24 198 1.457e-05 0.0005254
130 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 43 470 1.496e-05 0.0005356
131 TISSUE MORPHOGENESIS 47 533 1.586e-05 0.0005633
132 REGULATION OF ANATOMICAL STRUCTURE SIZE 43 472 1.659e-05 0.0005804
133 EPIDERMIS DEVELOPMENT 28 253 1.651e-05 0.0005804
134 CELLULAR RESPONSE TO ACID CHEMICAL 22 175 1.846e-05 0.000637
135 SKIN EPIDERMIS DEVELOPMENT 13 71 1.848e-05 0.000637
136 REGULATION OF ION HOMEOSTASIS 24 201 1.875e-05 0.0006417
137 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 52 616 1.897e-05 0.0006444
138 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 6 14 2.036e-05 0.0006866
139 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 12 62 2.153e-05 0.0007208
140 TAXIS 42 464 2.415e-05 0.0008026
141 PALLIUM DEVELOPMENT 20 153 2.472e-05 0.0008157
142 CELL JUNCTION ASSEMBLY 18 129 2.566e-05 0.0008408
143 REGULATION OF NEURON APOPTOTIC PROCESS 23 192 2.638e-05 0.0008581
144 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 75 1008 2.656e-05 0.0008581
145 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 56 689 2.689e-05 0.0008628
146 REGULATION OF GTPASE ACTIVITY 55 673 2.725e-05 0.0008685
147 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 30 289 2.889e-05 0.0009144
148 REGULATION OF MAP KINASE ACTIVITY 32 319 3.134e-05 0.0009852
149 BONE DEVELOPMENT 20 156 3.285e-05 0.001026
150 MUSCLE ORGAN DEVELOPMENT 29 277 3.337e-05 0.001035
151 NEGATIVE REGULATION OF EPITHELIAL CELL DIFFERENTIATION 9 37 3.444e-05 0.001061
152 GROWTH 38 410 3.494e-05 0.00107
153 CARDIAC MUSCLE CELL CONTRACTION 8 29 3.52e-05 0.00107
154 REGULATION OF CHONDROCYTE DIFFERENTIATION 10 46 3.637e-05 0.001099
155 CIRCULATORY SYSTEM PROCESS 35 366 3.715e-05 0.001115
156 EMBRYONIC ORGAN MORPHOGENESIS 29 279 3.809e-05 0.001129
157 MUSCLE CELL DIFFERENTIATION 26 237 3.802e-05 0.001129
158 TUBE MORPHOGENESIS 32 323 4e-05 0.001178
159 REGULATION OF MUSCLE CONTRACTION 19 147 4.581e-05 0.00134
160 POSITIVE REGULATION OF HYDROLASE ACTIVITY 68 905 4.702e-05 0.001359
161 REGULATION OF INTRACELLULAR TRANSPORT 51 621 4.682e-05 0.001359
162 CELL GROWTH 18 135 4.758e-05 0.001367
163 MULTICELLULAR ORGANISMAL SIGNALING 17 123 4.83e-05 0.001379
164 NEGATIVE REGULATION OF CELL DEATH 66 872 4.885e-05 0.001386
165 REGULATION OF CELL DEATH 100 1472 5.046e-05 0.001423
166 TELENCEPHALON DEVELOPMENT 25 228 5.367e-05 0.001504
167 REGULATION OF PHOSPHOLIPASE C ACTIVITY 9 39 5.401e-05 0.001505
168 REGULATION OF CELLULAR LOCALIZATION 89 1277 5.438e-05 0.001506
169 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 22 188 5.606e-05 0.001543
170 MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS 11 58 5.749e-05 0.001573
171 NEGATIVE REGULATION OF CELL PROLIFERATION 52 643 5.904e-05 0.001607
172 SYNAPSE ASSEMBLY 12 69 6.538e-05 0.001769
173 SYNAPTIC SIGNALING 38 424 7.182e-05 0.001932
174 RESPONSE TO ENDOGENOUS STIMULUS 98 1450 7.319e-05 0.001957
175 REGULATION OF VENTRICULAR CARDIAC MUSCLE CELL ACTION POTENTIAL 5 11 7.463e-05 0.001984
176 REGULATION OF SECRETION 55 699 7.59e-05 0.002007
177 PROTEIN AUTOPHOSPHORYLATION 22 192 7.698e-05 0.002024
178 GLAND DEVELOPMENT 36 395 7.857e-05 0.002054
179 REGULATION OF SMOOTH MUSCLE CONTRACTION 11 60 7.956e-05 0.002068
180 RESPONSE TO LIPID 66 888 8.386e-05 0.002168
181 POSITIVE REGULATION OF MAP KINASE ACTIVITY 23 207 8.597e-05 0.00221
182 CARDIAC CONDUCTION 13 82 8.897e-05 0.002275
183 REGULATION OF NEUROTRANSMITTER SECRETION 10 51 9.256e-05 0.002353
184 REGULATION OF AXONOGENESIS 20 168 9.46e-05 0.002392
185 PROTEIN PHOSPHORYLATION 69 944 9.607e-05 0.002416
186 REGULATION OF MUSCLE SYSTEM PROCESS 22 195 9.698e-05 0.002426
187 HAIR CYCLE 13 83 0.0001011 0.002503
188 MOLTING CYCLE 13 83 0.0001011 0.002503
189 REGULATION OF TRANSFERASE ACTIVITY 69 946 0.0001023 0.00252
190 REGULATION OF ION TRANSPORT 48 592 0.0001058 0.002592
191 RESPONSE TO MECHANICAL STIMULUS 23 210 0.0001071 0.002608
192 EYE DEVELOPMENT 31 326 0.0001124 0.002723
193 REGULATION OF ACTIN FILAMENT BASED PROCESS 30 312 0.0001182 0.00285
194 POSITIVE REGULATION OF NEUROTRANSMITTER SECRETION 5 12 0.0001231 0.002952
195 REGULATION OF CARTILAGE DEVELOPMENT 11 63 0.0001261 0.003008
196 CELL JUNCTION ORGANIZATION 21 185 0.000127 0.003014
197 CELL FATE COMMITMENT 24 227 0.0001328 0.003137
198 EMBRYONIC ORGAN DEVELOPMENT 36 406 0.0001364 0.003206
199 NEUROMUSCULAR PROCESS 14 97 0.0001373 0.00321
200 REGULATION OF NEUROTRANSMITTER TRANSPORT 11 64 0.000146 0.003396
201 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 16 122 0.00015 0.003456
202 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 16 122 0.00015 0.003456
203 POSITIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 6 19 0.0001509 0.003459
204 NEURON MIGRATION 15 110 0.0001541 0.003515
205 ADULT BEHAVIOR 17 135 0.0001563 0.003549
206 REGULATION OF TRANSMEMBRANE TRANSPORT 37 426 0.0001681 0.003796
207 CELL PROLIFERATION 52 672 0.000179 0.004023
208 REGULATION OF NEUROTRANSMITTER LEVELS 21 190 0.0001849 0.004136
209 NEGATIVE REGULATION OF MONOOXYGENASE ACTIVITY 5 13 0.0001924 0.00427
210 DEVELOPMENTAL CELL GROWTH 12 77 0.0001946 0.00427
211 POSITIVE REGULATION OF LIPASE ACTIVITY 11 66 0.0001939 0.00427
212 REGULATION OF CARDIAC MUSCLE CONTRACTION 11 66 0.0001939 0.00427
213 CELL CELL ADHESION 48 608 0.0001983 0.004332
214 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 17 138 0.0002046 0.004448
215 REGULATION OF EXTENT OF CELL GROWTH 14 101 0.0002124 0.004576
216 PROTEIN O LINKED GLYCOSYLATION 14 101 0.0002124 0.004576
217 CARDIAC MUSCLE CELL ACTION POTENTIAL 8 37 0.0002284 0.004863
218 ACTIVATION OF PROTEIN KINASE ACTIVITY 27 279 0.0002289 0.004863
219 CAMP MEDIATED SIGNALING 8 37 0.0002284 0.004863
220 ACTIN FILAMENT BASED PROCESS 38 450 0.0002435 0.005127
221 REGULATION OF CHEMOTAXIS 20 180 0.0002429 0.005127
222 CONNECTIVE TISSUE DEVELOPMENT 21 194 0.0002469 0.005161
223 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 22 208 0.0002473 0.005161
224 REGULATION OF STRIATED MUSCLE CONTRACTION 12 79 0.0002492 0.005177
225 NERVE DEVELOPMENT 11 68 0.0002546 0.005265
226 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 18 154 0.0002617 0.005342
227 LOCOMOTORY BEHAVIOR 20 181 0.0002616 0.005342
228 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 35 404 0.0002618 0.005342
229 REGULATION OF THE FORCE OF HEART CONTRACTION 7 29 0.0002731 0.005548
230 REGULATION OF SYNAPTIC VESICLE EXOCYTOSIS 6 21 0.0002789 0.005642
231 RESPONSE TO KETONE 20 182 0.0002814 0.005667
232 O GLYCAN PROCESSING 10 58 0.0002826 0.005667
233 VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING PATHWAY 5 14 0.000288 0.005752
234 SENSORY ORGAN MORPHOGENESIS 24 239 0.0002899 0.005764
235 INNER EAR MORPHOGENESIS 13 92 0.0002917 0.005776
236 RESPONSE TO NITROGEN COMPOUND 62 859 0.0003026 0.005967
237 REGULATION OF EPITHELIAL CELL PROLIFERATION 27 285 0.000322 0.006295
238 CELLULAR RESPONSE TO NITROGEN COMPOUND 41 505 0.0003211 0.006295
239 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 13 93 0.0003251 0.006328
240 VASCULOGENESIS 10 59 0.0003264 0.006328
241 RESPONSE TO EXTRACELLULAR STIMULUS 37 441 0.0003312 0.006369
242 WATER HOMEOSTASIS 11 70 0.0003305 0.006369
243 LEARNING 16 131 0.0003433 0.006519
244 POSITIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 7 30 0.0003422 0.006519
245 CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 7 30 0.0003422 0.006519
246 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 9 49 0.0003467 0.006557
247 FAT CELL DIFFERENTIATION 14 106 0.0003541 0.00667
248 RESPONSE TO ABIOTIC STIMULUS 71 1024 0.0003626 0.006804
249 DEVELOPMENTAL GROWTH 30 333 0.000366 0.00684
250 BONE CELL DEVELOPMENT 6 22 0.0003687 0.006854
251 CELL MATRIX ADHESION 15 119 0.0003698 0.006854
252 DICARBOXYLIC ACID TRANSPORT 11 71 0.0003751 0.006927
253 NEGATIVE REGULATION OF CELL DEVELOPMENT 28 303 0.0003775 0.006942
254 RESPONSE TO RETINOIC ACID 14 107 0.0003905 0.007153
255 FORELIMB MORPHOGENESIS 8 40 0.0004026 0.007317
256 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 26 274 0.0004019 0.007317
257 REGULATION OF DENDRITE DEVELOPMENT 15 120 0.000405 0.007332
258 SECOND MESSENGER MEDIATED SIGNALING 18 160 0.000419 0.007556
259 MUSCLE TISSUE DEVELOPMENT 26 275 0.000425 0.007606
260 REGULATION OF SYNAPTIC VESICLE TRANSPORT 7 31 0.0004246 0.007606
261 REGULATION OF HOMEOSTATIC PROCESS 37 447 0.0004288 0.007645
262 MEMBRANE DEPOLARIZATION 10 61 0.0004312 0.007658
263 RESPONSE TO WOUNDING 44 563 0.0004468 0.007905
264 MORPHOGENESIS OF AN EPITHELIUM 34 400 0.00045 0.007931
265 INNERVATION 6 23 0.0004795 0.008419
266 HEART PROCESS 12 85 0.0004977 0.008705
267 POSITIVE REGULATION OF SYNAPTIC TRANSMISSION 14 110 0.0005194 0.009052
268 POSITIVE REGULATION OF LOCOMOTION 35 420 0.0005366 0.009316
269 FOREBRAIN DEVELOPMENT 31 357 0.0005523 0.009554
270 DERMATAN SULFATE PROTEOGLYCAN METABOLIC PROCESS 5 16 0.0005819 0.009955
271 MEGAKARYOCYTE DEVELOPMENT 5 16 0.0005819 0.009955
272 POSITIVE REGULATION OF NEUROTRANSMITTER TRANSPORT 5 16 0.0005819 0.009955
273 NEGATIVE REGULATION OF PHOSPHORYLATION 35 422 0.0005846 0.009964
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 66 629 3.448e-10 3.203e-07
2 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 41 315 1.907e-09 8.856e-07
3 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 41 328 6.314e-09 1.955e-06
4 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 96 1199 6.777e-08 1.574e-05
5 REGULATORY REGION NUCLEIC ACID BINDING 71 818 1.997e-07 3.71e-05
6 SEQUENCE SPECIFIC DNA BINDING 84 1037 2.932e-07 4.54e-05
7 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 29 226 5.969e-07 7.921e-05
8 DOUBLE STRANDED DNA BINDING 64 764 2.691e-06 0.0003125
9 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 15 81 3.692e-06 0.000343
10 GROWTH FACTOR BINDING 19 123 3.408e-06 0.000343
11 GLYCOSAMINOGLYCAN BINDING 25 205 8.742e-06 0.0007383
12 KINASE BINDING 52 606 1.213e-05 0.0009389
13 PROTEIN DIMERIZATION ACTIVITY 84 1149 1.649e-05 0.001178
14 MOLECULAR FUNCTION REGULATOR 95 1353 2.26e-05 0.001399
15 RECEPTOR BINDING 102 1476 2.128e-05 0.001399
16 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 12 64 3.008e-05 0.001747
17 CORE PROMOTER PROXIMAL REGION DNA BINDING 35 371 4.909e-05 0.002551
18 MACROMOLECULAR COMPLEX BINDING 96 1399 4.943e-05 0.002551
19 IDENTICAL PROTEIN BINDING 85 1209 5.952e-05 0.00291
20 ENZYME BINDING 114 1737 6.303e-05 0.002928
21 PROTEIN KINASE A BINDING 9 42 0.0001004 0.004243
22 PROTEIN KINASE ACTIVITY 51 640 0.0001005 0.004243
23 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 24 228 0.0001421 0.00574
24 CALCIUM ION BINDING 53 697 0.0002392 0.009259
25 CYTOSKELETAL PROTEIN BINDING 60 819 0.0002567 0.009538
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 111 1151 6.354e-14 3.711e-11
2 NEURON PART 116 1265 5.078e-13 1.483e-10
3 NEURON PROJECTION 91 942 1.314e-11 2.558e-09
4 CELL PROJECTION 139 1786 3.397e-10 4.96e-08
5 INTRINSIC COMPONENT OF PLASMA MEMBRANE 129 1649 1.19e-09 1.39e-07
6 SOMATODENDRITIC COMPARTMENT 63 650 1.923e-08 1.871e-06
7 MEMBRANE REGION 92 1134 7.12e-08 5.94e-06
8 SYNAPSE 68 754 8.747e-08 6.385e-06
9 DENDRITE 47 451 1.549e-07 1.005e-05
10 CELL CELL JUNCTION 40 383 1.228e-06 7.173e-05
11 PLASMA MEMBRANE REGION 75 929 1.484e-06 7.879e-05
12 AXON 42 418 1.837e-06 8.941e-05
13 CYTOPLASMIC REGION 32 287 3.598e-06 0.0001611
14 PRESYNAPTIC ACTIVE ZONE 9 29 3.863e-06 0.0001611
15 CELL BODY 46 494 4.782e-06 0.0001862
16 SYNAPSE PART 53 610 7.034e-06 0.0002567
17 PROTEINACEOUS EXTRACELLULAR MATRIX 36 356 8.578e-06 0.0002947
18 MEMBRANE MICRODOMAIN 31 288 1.042e-05 0.000338
19 EXTRACELLULAR MATRIX 40 426 1.624e-05 0.0004992
20 GOLGI APPARATUS PART 68 893 3.109e-05 0.0008647
21 T TUBULE 10 45 2.968e-05 0.0008647
22 CONTRACTILE FIBER 24 211 4.174e-05 0.001108
23 GOLGI MEMBRANE 55 703 8.819e-05 0.002239
24 ACTIN BASED CELL PROJECTION 21 181 9.284e-05 0.002259
25 CELL SURFACE 58 757 0.0001006 0.002299
26 CELL PROJECTION PART 69 946 0.0001023 0.002299
27 PRESYNAPSE 28 283 0.0001215 0.002628
28 I BAND 16 121 0.000136 0.002837
29 PLASMA MEMBRANE RAFT 13 86 0.0001465 0.002951
30 POSTSYNAPSE 34 378 0.0001581 0.003077
31 SARCOLEMMA 16 125 0.0001997 0.003762
32 RECEPTOR COMPLEX 30 327 0.0002688 0.004905
33 ANCHORING JUNCTION 40 489 0.000325 0.005752
34 SYNAPTIC MEMBRANE 25 261 0.000448 0.007696
35 INTERCALATED DISC 9 51 0.0004728 0.00789
36 AXON PART 22 219 0.0005069 0.008224
37 CELL PROJECTION CYTOPLASM 9 52 0.0005488 0.008662
38 CELL CORTEX 23 238 0.0006587 0.009863
39 EXTERNAL SIDE OF PLASMA MEMBRANE 23 238 0.0006587 0.009863

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Calcium_signaling_pathway_hsa04020 21 182 0.0001005 0.005226
2 Rap1_signaling_pathway_hsa04015 22 206 0.0002156 0.005604
3 cAMP_signaling_pathway_hsa04024 21 198 0.0003264 0.005658
4 MAPK_signaling_pathway_hsa04010 27 295 0.0005526 0.007184
5 Hippo_signaling_pathway_hsa04390 17 154 0.0007438 0.007735
6 Focal_adhesion_hsa04510 19 199 0.002144 0.01858
7 Cell_adhesion_molecules_.CAMs._hsa04514 15 145 0.002823 0.02071
8 Jak_STAT_signaling_pathway_hsa04630 16 162 0.003318 0.02071
9 PI3K_Akt_signaling_pathway_hsa04151 28 352 0.003585 0.02071
10 Neuroactive_ligand_receptor_interaction_hsa04080 23 278 0.004916 0.02556
11 Gap_junction_hsa04540 10 88 0.007102 0.03243
12 Phospholipase_D_signaling_pathway_hsa04072 14 146 0.007484 0.03243
13 cGMP_PKG_signaling_pathway_hsa04022 15 163 0.008333 0.03333
14 Cytokine_cytokine_receptor_interaction_hsa04060 21 270 0.01351 0.0502
15 TGF_beta_signaling_pathway_hsa04350 9 84 0.01494 0.05181
16 Wnt_signaling_pathway_hsa04310 13 146 0.01731 0.05625
17 Ras_signaling_pathway_hsa04014 18 232 0.02156 0.06595
18 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 11 139 0.05602 0.1572
19 Regulation_of_actin_cytoskeleton_hsa04810 15 208 0.05744 0.1572
20 ECM_receptor_interaction_hsa04512 7 82 0.08303 0.2159
21 ErbB_signaling_pathway_hsa04012 7 85 0.09614 0.2381
22 Adherens_junction_hsa04520 6 72 0.1133 0.2679
23 Endocytosis_hsa04144 15 244 0.1563 0.3432
24 mTOR_signaling_pathway_hsa04150 10 151 0.1584 0.3432
25 Apelin_signaling_pathway_hsa04371 9 137 0.1802 0.3748
26 Apoptosis_multiple_species_hsa04215 3 33 0.1926 0.3852
27 Oocyte_meiosis_hsa04114 8 124 0.2118 0.4079
28 AMPK_signaling_pathway_hsa04152 7 121 0.3225 0.5844
29 ABC_transporters_hsa02010 3 45 0.3427 0.5844
30 Mitophagy_animal_hsa04137 4 65 0.3504 0.5844
31 Hedgehog_signaling_pathway_hsa04340 3 47 0.3681 0.5844
32 TNF_signaling_pathway_hsa04668 6 108 0.3782 0.5844
33 Tight_junction_hsa04530 9 170 0.3816 0.5844
34 p53_signaling_pathway_hsa04115 4 68 0.3821 0.5844
35 Ferroptosis_hsa04216 2 40 0.555 0.8239
36 FoxO_signaling_pathway_hsa04068 6 132 0.5704 0.8239
37 Phosphatidylinositol_signaling_system_hsa04070 4 99 0.6734 0.9081
38 Cell_cycle_hsa04110 5 124 0.6801 0.9081
39 HIF_1_signaling_pathway_hsa04066 4 100 0.6811 0.9081
40 Peroxisome_hsa04146 3 83 0.7414 0.929
41 Cellular_senescence_hsa04218 6 160 0.7503 0.929
42 Sphingolipid_signaling_pathway_hsa04071 4 118 0.7975 0.9644
43 Autophagy_animal_hsa04140 4 128 0.8457 0.9913
44 Necroptosis_hsa04217 5 164 0.878 0.9913
45 Apoptosis_hsa04210 4 138 0.8839 0.9913

Quest ID: 0a98fe9107306985966f3826161d259c