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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-3p ABCA1 0.47 0 -1.41 0 mirMAP; miRNATAP -0.16 0.00012 NA
2 hsa-let-7a-3p ABCC9 0.47 0 -2.42 0 mirMAP -0.35 0 NA
3 hsa-let-7a-3p ABCD2 0.47 0 -4.13 0 mirMAP -0.5 0 NA
4 hsa-let-7a-3p ABI3BP 0.47 0 -2.67 0 miRNATAP -0.6 0 NA
5 hsa-let-7a-3p ADAM23 0.47 0 -0.63 0.00091 mirMAP -0.35 0 NA
6 hsa-let-7a-3p ADAMTS5 0.47 0 -3.55 0 mirMAP -0.35 0 NA
7 hsa-let-7a-3p ADAMTSL3 0.47 0 -1.39 0 MirTarget -0.13 0.04911 NA
8 hsa-let-7a-3p ADCYAP1 0.47 0 -0.67 0.02162 miRNATAP -0.26 0.01703 NA
9 hsa-let-7a-3p ADD3 0.47 0 -1.66 0 mirMAP; miRNATAP -0.13 0.00891 NA
10 hsa-let-7a-3p AFF2 0.47 0 -1.78 0 mirMAP -0.3 2.0E-5 NA
11 hsa-let-7a-3p AKAP12 0.47 0 -2.76 0 miRNATAP -0.46 0 NA
12 hsa-let-7a-3p AMIGO2 0.47 0 -1.58 0 MirTarget; mirMAP -0.15 0.03432 NA
13 hsa-let-7a-3p AMOTL1 0.47 0 -1.81 0 mirMAP -0.2 9.0E-5 NA
14 hsa-let-7a-3p AMOTL2 0.47 0 -1.57 0 miRNATAP -0.21 0 NA
15 hsa-let-7a-3p ANO1 0.47 0 -0.88 0 MirTarget; miRNATAP -0.18 0.00235 NA
16 hsa-let-7a-3p ARHGAP20 0.47 0 -3.51 0 MirTarget; miRNATAP -0.48 0 NA
17 hsa-let-7a-3p ARHGAP28 0.47 0 -1.18 0 mirMAP -0.2 0.00079 NA
18 hsa-let-7a-3p ARHGAP29 0.47 0 -1.05 0 mirMAP -0.15 0.00132 NA
19 hsa-let-7a-3p ARID5B 0.47 0 -1.75 0 miRNATAP -0.26 0 NA
20 hsa-let-7a-3p ARL10 0.47 0 -1.27 0 mirMAP -0.13 0.01783 NA
21 hsa-let-7a-3p ARRDC3 0.47 0 -1.47 0 MirTarget -0.12 0.00354 NA
22 hsa-let-7a-3p ART4 0.47 0 -3.25 0 mirMAP -0.54 0 NA
23 hsa-let-7a-3p ARX 0.47 0 0.32 0.32475 miRNATAP -0.31 0.01132 NA
24 hsa-let-7a-3p AXIN2 0.47 0 -0.9 0 miRNATAP -0.16 0.00126 NA
25 hsa-let-7a-3p BCAS1 0.47 0 1.43 1.0E-5 mirMAP -0.4 0.00083 NA
26 hsa-let-7a-3p BCL11B 0.47 0 -0.26 0.19747 mirMAP; miRNATAP -0.19 0.01073 NA
27 hsa-let-7a-3p BCL6 0.47 0 -1.26 0 miRNATAP -0.12 0.00243 NA
28 hsa-let-7a-3p BMP3 0.47 0 -4.25 0 MirTarget; mirMAP -0.58 0 NA
29 hsa-let-7a-3p BMPER 0.47 0 -3.4 0 MirTarget -0.51 0 NA
30 hsa-let-7a-3p BNC1 0.47 0 -2.84 0 MirTarget -0.26 0.01145 NA
31 hsa-let-7a-3p BNC2 0.47 0 -0.78 0 mirMAP -0.31 0 NA
32 hsa-let-7a-3p BST1 0.47 0 -1.12 0 MirTarget -0.17 3.0E-5 NA
33 hsa-let-7a-3p BTNL9 0.47 0 -4.3 0 MirTarget -0.6 0 NA
34 hsa-let-7a-3p C4orf32 0.47 0 -0.94 0 mirMAP -0.11 0.04082 NA
35 hsa-let-7a-3p C8orf34 0.47 0 -2.78 0 mirMAP -0.31 0.00058 NA
36 hsa-let-7a-3p CACNA1C 0.47 0 -0.83 0 MirTarget -0.24 0 NA
37 hsa-let-7a-3p CACNA2D1 0.47 0 -3.14 0 mirMAP -0.29 0.00748 NA
38 hsa-let-7a-3p CALN1 0.47 0 -2.71 0 mirMAP -0.67 0 NA
39 hsa-let-7a-3p CBLN4 0.47 0 -1.61 0 MirTarget -0.46 0 NA
40 hsa-let-7a-3p CCDC141 0.47 0 -2.66 0 mirMAP -0.35 0 NA
41 hsa-let-7a-3p CCDC50 0.47 0 -1.33 0 miRNATAP -0.11 8.0E-5 NA
42 hsa-let-7a-3p CCND2 0.47 0 -1.32 0 mirMAP -0.22 0 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2
43 hsa-let-7a-3p CD302 0.47 0 -1.77 0 mirMAP -0.16 0.00023 NA
44 hsa-let-7a-3p CD38 0.47 0 -0.38 0.12332 MirTarget -0.34 0.00027 NA
45 hsa-let-7a-3p CDC14B 0.47 0 -2.02 0 miRNATAP -0.19 4.0E-5 NA
46 hsa-let-7a-3p CELF2 0.47 0 -2.12 0 miRNATAP -0.28 0 NA
47 hsa-let-7a-3p CHL1 0.47 0 -4.19 0 MirTarget; miRNATAP -0.55 0 NA
48 hsa-let-7a-3p CNKSR2 0.47 0 -3.5 0 MirTarget; mirMAP; miRNATAP -0.27 0.00318 NA
49 hsa-let-7a-3p CNR1 0.47 0 -2.7 0 mirMAP -0.34 0.00031 NA
50 hsa-let-7a-3p CNTN1 0.47 0 -2.3 0 MirTarget; miRNATAP -0.48 0 NA
51 hsa-let-7a-3p COL13A1 0.47 0 1.34 0 miRNATAP -0.2 0.00106 NA
52 hsa-let-7a-3p COL15A1 0.47 0 -0.8 0 MirTarget -0.2 0 NA
53 hsa-let-7a-3p COL1A2 0.47 0 1.52 0 MirTarget -0.19 0.0027 NA
54 hsa-let-7a-3p COL4A3BP 0.47 0 -1.02 0 MirTarget; mirMAP; miRNATAP -0.1 0.00105 NA
55 hsa-let-7a-3p COL4A4 0.47 0 -1.2 0 mirMAP -0.22 0.00139 NA
56 hsa-let-7a-3p CRIM1 0.47 0 -2.03 0 MirTarget -0.11 0.03605 NA
57 hsa-let-7a-3p CUX2 0.47 0 -1.98 0 MirTarget; miRNATAP -0.37 0.00056 NA
58 hsa-let-7a-3p CX3CR1 0.47 0 -1.66 0 MirTarget -0.2 0.00648 NA
59 hsa-let-7a-3p CYBRD1 0.47 0 -1.65 0 mirMAP -0.19 0.00119 NA
60 hsa-let-7a-3p CYP1B1 0.47 0 -0.37 0.02194 mirMAP -0.26 2.0E-5 NA
61 hsa-let-7a-3p DACT1 0.47 0 0.22 0.11609 MirTarget -0.24 0 NA
62 hsa-let-7a-3p DGAT2 0.47 0 -3.01 0 MirTarget -0.16 0.04832 NA
63 hsa-let-7a-3p DIO2 0.47 0 0.66 0.00054 mirMAP -0.25 0.0005 NA
64 hsa-let-7a-3p DKK3 0.47 0 -1.29 0 MirTarget; miRNATAP -0.22 0 NA
65 hsa-let-7a-3p DLL1 0.47 0 -0.95 0 miRNATAP -0.33 0 NA
66 hsa-let-7a-3p DLL4 0.47 0 -0.84 0 miRNATAP -0.24 0 NA
67 hsa-let-7a-3p DNAJB5 0.47 0 -0.23 0.00594 miRNATAP -0.11 0.00064 NA
68 hsa-let-7a-3p DNALI1 0.47 0 -0.01 0.9622 MirTarget; miRNATAP -0.2 0.0486 NA
69 hsa-let-7a-3p DNM3 0.47 0 -0.81 0 MirTarget -0.25 0 NA
70 hsa-let-7a-3p DOCK11 0.47 0 -2.19 0 MirTarget; miRNATAP -0.35 0 NA
71 hsa-let-7a-3p DOK6 0.47 0 -0.41 0.00604 mirMAP -0.16 0.0031 NA
72 hsa-let-7a-3p DZIP1 0.47 0 -1.07 0 MirTarget; mirMAP -0.11 0.02617 NA
73 hsa-let-7a-3p EBF1 0.47 0 -3.06 0 mirMAP; miRNATAP -0.41 0 NA
74 hsa-let-7a-3p EBF3 0.47 0 -2.98 0 MirTarget; miRNATAP -0.37 0 NA
75 hsa-let-7a-3p EFNB1 0.47 0 -0.93 0 MirTarget; miRNATAP -0.12 0.00052 NA
76 hsa-let-7a-3p EFNB2 0.47 0 -0.9 0 miRNATAP -0.12 0.00387 NA
77 hsa-let-7a-3p EGFL6 0.47 0 -0.57 0.01271 MirTarget -0.19 0.02481 NA
78 hsa-let-7a-3p ELK3 0.47 0 -0.9 0 MirTarget -0.19 0 NA
79 hsa-let-7a-3p EML1 0.47 0 -0.76 0 MirTarget -0.12 0.00244 NA
80 hsa-let-7a-3p ERAP1 0.47 0 -0.85 0 MirTarget -0.1 0.00203 NA
81 hsa-let-7a-3p EVI2A 0.47 0 0.38 0.00065 MirTarget -0.12 0.00475 NA
82 hsa-let-7a-3p F2RL1 0.47 0 0.14 0.30879 MirTarget -0.12 0.02303 NA
83 hsa-let-7a-3p F3 0.47 0 -2.18 0 MirTarget; miRNATAP -0.31 0 NA
84 hsa-let-7a-3p FAM117A 0.47 0 -0.69 0 miRNATAP -0.12 0.00026 NA
85 hsa-let-7a-3p FAM126A 0.47 0 -2.26 0 MirTarget -0.19 0.0005 NA
86 hsa-let-7a-3p FAM26E 0.47 0 -0.82 0 mirMAP -0.23 0 NA
87 hsa-let-7a-3p FAM47E 0.47 0 -1.19 0 MirTarget -0.15 0.0278 NA
88 hsa-let-7a-3p FAT3 0.47 0 -1.4 0 miRNATAP -0.33 5.0E-5 NA
89 hsa-let-7a-3p FBN1 0.47 0 -0.64 7.0E-5 mirMAP -0.25 4.0E-5 NA
90 hsa-let-7a-3p FGF13 0.47 0 -0.87 0 MirTarget; miRNATAP -0.13 0.04485 NA
91 hsa-let-7a-3p FGF2 0.47 0 -3.62 0 mirMAP -0.29 0.00048 NA
92 hsa-let-7a-3p FGF7 0.47 0 -2.05 0 MirTarget; miRNATAP -0.29 0 NA
93 hsa-let-7a-3p FKBP5 0.47 0 -0.91 0 mirMAP -0.14 0.01954 NA
94 hsa-let-7a-3p FLRT2 0.47 0 -2.2 0 mirMAP -0.38 0 NA
95 hsa-let-7a-3p FLRT3 0.47 0 -0.97 0.00018 mirMAP -0.22 0.02348 NA
96 hsa-let-7a-3p FNIP2 0.47 0 -1.4 0 mirMAP -0.15 0.01079 NA
97 hsa-let-7a-3p FOXO1 0.47 0 -1.99 0 MirTarget; miRNATAP -0.31 0 NA
98 hsa-let-7a-3p FOXP2 0.47 0 -3.11 0 MirTarget; mirMAP -0.45 0 NA
99 hsa-let-7a-3p FRMD6 0.47 0 -0.87 0 MirTarget; mirMAP -0.14 0.00125 NA
100 hsa-let-7a-3p FSTL1 0.47 0 -1.28 0 mirMAP -0.24 0 NA
101 hsa-let-7a-3p FYN 0.47 0 -0.97 0 miRNATAP -0.18 0 NA
102 hsa-let-7a-3p FZD4 0.47 0 -2.46 0 mirMAP -0.41 0 NA
103 hsa-let-7a-3p GABRA2 0.47 0 -3.43 0 mirMAP -0.46 1.0E-5 NA
104 hsa-let-7a-3p GAS1 0.47 0 -1.66 0 miRNATAP -0.3 0 NA
105 hsa-let-7a-3p GFRA2 0.47 0 -2.63 0 mirMAP -0.51 0 NA
106 hsa-let-7a-3p GLIS3 0.47 0 0.2 0.17318 mirMAP -0.11 0.04424 NA
107 hsa-let-7a-3p GP1BA 0.47 0 -0.3 0.11371 miRNATAP -0.27 0.00014 NA
108 hsa-let-7a-3p GPAM 0.47 0 -3.76 0 mirMAP -0.36 0 NA
109 hsa-let-7a-3p GPCPD1 0.47 0 -0.76 0 miRNATAP -0.14 3.0E-5 NA
110 hsa-let-7a-3p GPR88 0.47 0 -2.17 0 MirTarget -0.31 0.00027 NA
111 hsa-let-7a-3p GREM1 0.47 0 0.93 0 mirMAP -0.27 0.00039 NA
112 hsa-let-7a-3p GRIA3 0.47 0 -1.91 0 miRNATAP -0.17 0.04565 NA
113 hsa-let-7a-3p GRIN2A 0.47 0 -1.83 0 mirMAP -0.36 1.0E-5 NA
114 hsa-let-7a-3p GRK5 0.47 0 -1.21 0 MirTarget; miRNATAP -0.17 0 NA
115 hsa-let-7a-3p GULP1 0.47 0 -1.94 0 MirTarget; mirMAP -0.34 0 NA
116 hsa-let-7a-3p HCN4 0.47 0 0.08 0.7152 miRNATAP -0.2 0.02238 NA
117 hsa-let-7a-3p HGF 0.47 0 -1.5 0 mirMAP -0.37 0 NA
118 hsa-let-7a-3p HIC1 0.47 0 -0.68 0 MirTarget -0.4 0 NA
119 hsa-let-7a-3p HLF 0.47 0 -3.73 0 mirMAP -0.44 0 NA
120 hsa-let-7a-3p HOXA9 0.47 0 -2.52 0 miRNATAP -0.27 0.00019 NA
121 hsa-let-7a-3p HOXC8 0.47 0 -0.48 1.0E-5 miRNATAP -0.11 0.00444 NA
122 hsa-let-7a-3p HSD17B11 0.47 0 -1.41 0 MirTarget -0.29 0 NA
123 hsa-let-7a-3p HUNK 0.47 0 -1.41 0 mirMAP -0.28 9.0E-5 NA
124 hsa-let-7a-3p ID1 0.47 0 -1.08 0 MirTarget; miRNATAP -0.29 0 NA
125 hsa-let-7a-3p IGF1 0.47 0 -2.75 0 mirMAP -0.6 0 NA
126 hsa-let-7a-3p IGFBP3 0.47 0 -0.74 0 miRNATAP -0.11 0.00877 NA
127 hsa-let-7a-3p IKZF2 0.47 0 -0.14 0.32727 MirTarget; miRNATAP -0.14 0.01025 NA
128 hsa-let-7a-3p INHBB 0.47 0 -1.41 0 mirMAP -0.33 0 NA
129 hsa-let-7a-3p IPCEF1 0.47 0 -0.25 0.07171 mirMAP -0.14 0.00756 NA
130 hsa-let-7a-3p ITGA3 0.47 0 -0.3 0.01075 MirTarget; miRNATAP -0.12 0.00457 NA
131 hsa-let-7a-3p ITM2C 0.47 0 -0.29 0.02335 MirTarget -0.17 0.00051 NA
132 hsa-let-7a-3p JAG2 0.47 0 -0.62 0 miRNATAP -0.14 0.00018 NA
133 hsa-let-7a-3p JDP2 0.47 0 -0.46 0 mirMAP -0.19 0 NA
134 hsa-let-7a-3p KALRN 0.47 0 -1.51 0 miRNATAP -0.12 0.01614 NA
135 hsa-let-7a-3p KCNJ15 0.47 0 -0.3 0.06812 MirTarget -0.19 0.00171 NA
136 hsa-let-7a-3p KCNJ16 0.47 0 -5.39 0 mirMAP -0.65 0 NA
137 hsa-let-7a-3p KCNMB4 0.47 0 -0.26 0.03635 MirTarget -0.17 0.00036 NA
138 hsa-let-7a-3p KCNT2 0.47 0 -1.82 0 mirMAP -0.24 0.00013 NA
139 hsa-let-7a-3p KCTD12 0.47 0 -1.8 0 MirTarget -0.26 0 NA
140 hsa-let-7a-3p KIAA0408 0.47 0 -6.78 0 MirTarget -0.79 0 NA
141 hsa-let-7a-3p KIT 0.47 0 -3.56 0 mirMAP -0.31 0.00056 NA
142 hsa-let-7a-3p KLF4 0.47 0 -2.57 0 MirTarget; miRNATAP -0.4 0 NA
143 hsa-let-7a-3p KLF6 0.47 0 -1.37 0 miRNATAP -0.15 4.0E-5 NA
144 hsa-let-7a-3p KLF7 0.47 0 -0.96 0 miRNATAP -0.18 0.00056 NA
145 hsa-let-7a-3p KLF8 0.47 0 -1.47 0 mirMAP -0.25 0 NA
146 hsa-let-7a-3p KLHL3 0.47 0 -1.43 0 mirMAP; miRNATAP -0.2 0 NA
147 hsa-let-7a-3p KLHL4 0.47 0 -2.15 0 mirMAP -0.26 0.0001 NA
148 hsa-let-7a-3p LAMB1 0.47 0 -0.36 0.00037 MirTarget -0.15 5.0E-5 NA
149 hsa-let-7a-3p LEPR 0.47 0 -3.24 0 mirMAP -0.39 0 NA
150 hsa-let-7a-3p LIFR 0.47 0 -3.04 0 mirMAP -0.28 2.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 74 1672 2.305e-18 6.566e-15
2 NEUROGENESIS 67 1402 2.822e-18 6.566e-15
3 REGULATION OF CELL DIFFERENTIATION 66 1492 2.604e-16 4.038e-13
4 ORGAN MORPHOGENESIS 47 841 2.218e-15 2.58e-12
5 TISSUE DEVELOPMENT 64 1518 8.026e-15 7.469e-12
6 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 54 1142 1.544e-14 1.166e-11
7 CARDIOVASCULAR SYSTEM DEVELOPMENT 44 788 2.004e-14 1.166e-11
8 CIRCULATORY SYSTEM DEVELOPMENT 44 788 2.004e-14 1.166e-11
9 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 60 1395 2.801e-14 1.448e-11
10 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 42 750 7.632e-14 3.551e-11
11 BLOOD VESSEL MORPHOGENESIS 29 364 1.388e-13 5.869e-11
12 REGULATION OF CELL DEVELOPMENT 44 836 1.58e-13 6.126e-11
13 VASCULATURE DEVELOPMENT 32 469 5.037e-13 1.803e-10
14 NEURON DIFFERENTIATION 44 874 7.254e-13 2.411e-10
15 TUBE DEVELOPMENT 34 552 1.623e-12 5.034e-10
16 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 47 1021 2.633e-12 7.656e-10
17 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 65 1784 3.868e-12 1.059e-09
18 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 53 1275 4.433e-12 1.146e-09
19 REGULATION OF CELL PROLIFERATION 58 1496 6.185e-12 1.515e-09
20 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 61 1656 1.336e-11 3.108e-09
21 CELL FATE COMMITMENT 21 227 2.237e-11 4.956e-09
22 POSITIVE REGULATION OF GENE EXPRESSION 62 1733 2.963e-11 6.267e-09
23 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 44 983 3.609e-11 7.301e-09
24 LOCOMOTION 47 1114 5.332e-11 1.034e-08
25 REGULATION OF CELLULAR COMPONENT MOVEMENT 38 771 5.88e-11 1.094e-08
26 UROGENITAL SYSTEM DEVELOPMENT 23 299 1.042e-10 1.866e-08
27 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 38 801 1.765e-10 3.041e-08
28 REGULATION OF NEURON DIFFERENTIATION 31 554 1.851e-10 3.076e-08
29 REGULATION OF MAPK CASCADE 34 660 2.074e-10 3.327e-08
30 REGULATION OF CELL PROJECTION ORGANIZATION 31 558 2.21e-10 3.428e-08
31 EMBRYO DEVELOPMENT 40 894 3.165e-10 4.751e-08
32 POSITIVE REGULATION OF CELL COMMUNICATION 55 1532 4.361e-10 5.369e-08
33 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 61 1805 4.401e-10 5.369e-08
34 REGULATION OF POSTSYNAPTIC MEMBRANE POTENTIAL 11 55 3.735e-10 5.369e-08
35 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 62 1848 4.084e-10 5.369e-08
36 EMBRYONIC MORPHOGENESIS 30 539 4.212e-10 5.369e-08
37 REGULATION OF PROTEIN MODIFICATION PROCESS 59 1710 4.118e-10 5.369e-08
38 NEGATIVE REGULATION OF CELL DIFFERENTIATION 32 609 4.5e-10 5.369e-08
39 REGULATION OF PHOSPHORUS METABOLIC PROCESS 57 1618 4.005e-10 5.369e-08
40 EPITHELIUM DEVELOPMENT 41 945 4.652e-10 5.412e-08
41 RESPONSE TO ENDOGENOUS STIMULUS 53 1450 5.107e-10 5.796e-08
42 REGULATION OF CELL DEATH 53 1472 8.716e-10 9.656e-08
43 POSITIVE REGULATION OF CELL PROLIFERATION 37 814 1.021e-09 1.105e-07
44 SENSORY ORGAN DEVELOPMENT 28 493 1.063e-09 1.125e-07
45 HEAD DEVELOPMENT 34 709 1.332e-09 1.377e-07
46 TISSUE MORPHOGENESIS 29 533 1.412e-09 1.379e-07
47 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 50 1360 1.422e-09 1.379e-07
48 POSITIVE REGULATION OF CELL DIFFERENTIATION 37 823 1.378e-09 1.379e-07
49 CENTRAL NERVOUS SYSTEM DEVELOPMENT 38 872 1.915e-09 1.818e-07
50 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 42 1036 2.129e-09 1.942e-07
51 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 42 1036 2.129e-09 1.942e-07
52 ANGIOGENESIS 21 293 2.492e-09 2.23e-07
53 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 44 1135 3.292e-09 2.89e-07
54 MORPHOGENESIS OF A BRANCHING STRUCTURE 16 167 3.424e-09 2.951e-07
55 NEGATIVE REGULATION OF CELL COMMUNICATION 45 1192 4.809e-09 4.069e-07
56 NEGATIVE REGULATION OF CELL DEATH 37 872 6.505e-09 5.405e-07
57 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 25 437 7.527e-09 6.144e-07
58 REGULATION OF EPITHELIAL CELL PROLIFERATION 20 285 8.647e-09 6.937e-07
59 REGULATION OF NEURON PROJECTION DEVELOPMENT 24 408 8.895e-09 7.015e-07
60 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 14 133 9.893e-09 7.546e-07
61 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 40 1008 9.795e-09 7.546e-07
62 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 51 1492 1.092e-08 8.199e-07
63 POSITIVE REGULATION OF RESPONSE TO STIMULUS 60 1929 1.451e-08 1.072e-06
64 CELL DEVELOPMENT 49 1426 1.893e-08 1.355e-06
65 BIOLOGICAL ADHESION 40 1032 1.875e-08 1.355e-06
66 CELL MOTILITY 35 835 2.351e-08 1.633e-06
67 LOCALIZATION OF CELL 35 835 2.351e-08 1.633e-06
68 TAXIS 25 464 2.464e-08 1.686e-06
69 MORPHOGENESIS OF AN EPITHELIUM 23 400 2.795e-08 1.885e-06
70 POSITIVE REGULATION OF CELL DEVELOPMENT 25 472 3.441e-08 2.287e-06
71 RESPONSE TO GROWTH FACTOR 25 475 3.892e-08 2.551e-06
72 EPITHELIAL CELL FATE COMMITMENT 6 15 4.208e-08 2.719e-06
73 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 32 740 4.833e-08 3.081e-06
74 BEHAVIOR 26 516 4.922e-08 3.095e-06
75 REGULATION OF TRANSPORT 56 1804 5.271e-08 3.27e-06
76 SINGLE ORGANISM BEHAVIOR 22 384 6.029e-08 3.691e-06
77 NEURON PROJECTION GUIDANCE 16 205 6.367e-08 3.848e-06
78 REGULATION OF VASCULATURE DEVELOPMENT 17 233 6.592e-08 3.933e-06
79 TUBE MORPHOGENESIS 20 323 6.962e-08 4.101e-06
80 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 37 957 7.229e-08 4.205e-06
81 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 8 39 8e-08 4.596e-06
82 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 38 1004 8.185e-08 4.644e-06
83 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 33 799 8.641e-08 4.844e-06
84 POSITIVE REGULATION OF MOLECULAR FUNCTION 55 1791 1.018e-07 5.642e-06
85 HEART DEVELOPMENT 24 466 1.101e-07 6.027e-06
86 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 30 689 1.126e-07 6.091e-06
87 ACTION POTENTIAL 11 94 1.3e-07 6.95e-06
88 NEURON PROJECTION DEVELOPMENT 26 545 1.443e-07 7.632e-06
89 CELLULAR COMPONENT MORPHOGENESIS 35 900 1.466e-07 7.666e-06
90 EMBRYONIC ORGAN DEVELOPMENT 22 406 1.591e-07 8.225e-06
91 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 25 513 1.699e-07 8.686e-06
92 REGULATION OF MEMBRANE POTENTIAL 20 343 1.845e-07 9.33e-06
93 NEGATIVE REGULATION OF GENE EXPRESSION 48 1493 2.03e-07 1.005e-05
94 REGULATION OF ION TRANSPORT 27 592 2.022e-07 1.005e-05
95 RESPONSE TO ORGANIC CYCLIC COMPOUND 35 917 2.29e-07 1.122e-05
96 POSITIVE REGULATION OF LOCOMOTION 22 420 2.846e-07 1.365e-05
97 SKELETAL SYSTEM DEVELOPMENT 23 455 2.844e-07 1.365e-05
98 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 16 229 2.914e-07 1.375e-05
99 REGULATION OF DEVELOPMENTAL GROWTH 18 289 2.926e-07 1.375e-05
100 NEGATIVE REGULATION OF PHOSPHORYLATION 22 422 3.085e-07 1.436e-05
101 CELL CELL SIGNALING 31 767 3.503e-07 1.598e-05
102 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 16 232 3.475e-07 1.598e-05
103 EYE DEVELOPMENT 19 326 3.789e-07 1.712e-05
104 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 23 465 4.162e-07 1.862e-05
105 FAT CELL DIFFERENTIATION 11 106 4.479e-07 1.985e-05
106 AMEBOIDAL TYPE CELL MIGRATION 13 154 4.543e-07 1.994e-05
107 CELL PROJECTION ORGANIZATION 34 902 4.608e-07 2.004e-05
108 POSITIVE REGULATION OF MAPK CASCADE 23 470 5.014e-07 2.16e-05
109 REGULATION OF SYSTEM PROCESS 24 507 5.109e-07 2.181e-05
110 SYSTEM PROCESS 53 1785 5.248e-07 2.22e-05
111 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 18 303 5.852e-07 2.453e-05
112 REGULATION OF ORGAN MORPHOGENESIS 16 242 6.124e-07 2.544e-05
113 NEURON MIGRATION 11 110 6.523e-07 2.686e-05
114 CELL PROLIFERATION 28 672 7.361e-07 3.005e-05
115 GROWTH 21 410 7.684e-07 3.109e-05
116 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 34 926 8.362e-07 3.354e-05
117 RESPONSE TO OXYGEN CONTAINING COMPOUND 44 1381 9.007e-07 3.582e-05
118 REGULATION OF ENDOTHELIAL CELL MIGRATION 11 114 9.348e-07 3.686e-05
119 RESPONSE TO WOUNDING 25 563 9.505e-07 3.717e-05
120 RESPONSE TO EXTERNAL STIMULUS 53 1821 9.68e-07 3.754e-05
121 COGNITION 16 251 9.944e-07 3.793e-05
122 REGULATION OF LIPID METABOLIC PROCESS 17 282 9.884e-07 3.793e-05
123 REGULATION OF EPITHELIAL CELL MIGRATION 13 166 1.071e-06 4.052e-05
124 CELL ACTIVATION 25 568 1.116e-06 4.186e-05
125 NEURON DEVELOPMENT 28 687 1.136e-06 4.229e-05
126 EPITHELIAL CELL DIFFERENTIATION 23 495 1.223e-06 4.516e-05
127 RESPIRATORY SYSTEM DEVELOPMENT 14 197 1.327e-06 4.862e-05
128 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 12 144 1.448e-06 5.265e-05
129 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 24 541 1.607e-06 5.753e-05
130 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 24 541 1.607e-06 5.753e-05
131 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 46 1517 1.916e-06 6.807e-05
132 REGULATION OF HYDROLASE ACTIVITY 42 1327 1.953e-06 6.834e-05
133 POSITIVE REGULATION OF CATALYTIC ACTIVITY 46 1518 1.951e-06 6.834e-05
134 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 32 876 2.009e-06 6.977e-05
135 REGULATION OF SYNAPSE ASSEMBLY 9 79 2.307e-06 7.95e-05
136 KIDNEY EPITHELIUM DEVELOPMENT 11 125 2.336e-06 7.994e-05
137 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 14 207 2.385e-06 8.099e-05
138 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 38 1152 2.432e-06 8.199e-05
139 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 18 337 2.678e-06 8.899e-05
140 RESPONSE TO LIPID 32 888 2.674e-06 8.899e-05
141 NEURONAL ACTION POTENTIAL 6 28 2.698e-06 8.903e-05
142 POSITIVE REGULATION OF KINASE ACTIVITY 22 482 2.802e-06 9.182e-05
143 MEMBRANE DEPOLARIZATION 8 61 2.897e-06 9.425e-05
144 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 12 154 2.938e-06 9.493e-05
145 POSITIVE REGULATION OF NEURON DIFFERENTIATION 17 306 3.008e-06 9.653e-05
146 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 16 274 3.119e-06 9.941e-05
147 HEART MORPHOGENESIS 14 212 3.154e-06 9.984e-05
148 NEGATIVE REGULATION OF CELL PROLIFERATION 26 643 3.223e-06 0.0001013
149 REGULATION OF RESPONSE TO WOUNDING 20 413 3.325e-06 0.0001038
150 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 11 131 3.699e-06 0.0001147
151 SPROUTING ANGIOGENESIS 7 45 3.798e-06 0.000117
152 EMBRYONIC ORGAN MORPHOGENESIS 16 279 3.934e-06 0.0001204
153 REGULATION OF KINASE ACTIVITY 29 776 4.032e-06 0.0001226
154 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 36 1087 4.2e-06 0.0001269
155 CELLULAR RESPONSE TO LIPID 21 457 4.272e-06 0.0001283
156 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 25 616 4.707e-06 0.0001393
157 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 22 498 4.732e-06 0.0001393
158 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 25 616 4.707e-06 0.0001393
159 CHEMICAL HOMEOSTASIS 31 874 5.332e-06 0.000156
160 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 11 138 6.127e-06 0.0001779
161 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 16 289 6.156e-06 0.0001779
162 REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 5 19 6.408e-06 0.0001822
163 EAR DEVELOPMENT 13 195 6.407e-06 0.0001822
164 REGULATION OF STEM CELL DIFFERENTIATION 10 113 6.421e-06 0.0001822
165 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 21 470 6.576e-06 0.0001854
166 RESPONSE TO ALCOHOL 18 362 7.223e-06 0.0002025
167 TELENCEPHALON DEVELOPMENT 14 228 7.315e-06 0.0002038
168 REGULATION OF GROWTH 25 633 7.535e-06 0.0002075
169 NEPHRON DEVELOPMENT 10 115 7.513e-06 0.0002075
170 REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 7 50 7.853e-06 0.0002149
171 NEURON PROJECTION MORPHOGENESIS 19 402 8.293e-06 0.0002256
172 RESPONSE TO FLUID SHEAR STRESS 6 34 8.945e-06 0.000242
173 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 18 368 9.039e-06 0.0002431
174 DEVELOPMENTAL GROWTH 17 333 9.227e-06 0.0002467
175 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 10 118 9.451e-06 0.0002513
176 SYNAPSE ORGANIZATION 11 145 9.844e-06 0.0002602
177 MODULATION OF SYNAPTIC TRANSMISSION 16 301 1.026e-05 0.0002698
178 REGULATION OF HOMEOSTATIC PROCESS 20 447 1.073e-05 0.0002789
179 POSITIVE REGULATION OF CELL DEATH 24 605 1.072e-05 0.0002789
180 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 10 121 1.181e-05 0.0003052
181 LEUKOCYTE ACTIVATION 19 414 1.255e-05 0.0003225
182 MULTICELLULAR ORGANISMAL SIGNALING 10 123 1.364e-05 0.0003488
183 SENSORY PERCEPTION OF PAIN 8 75 1.39e-05 0.0003534
184 REGULATION OF CHEMOTAXIS 12 180 1.455e-05 0.0003679
185 MUSCLE ORGAN DEVELOPMENT 15 277 1.562e-05 0.0003928
186 POSITIVE REGULATION OF BINDING 10 127 1.807e-05 0.000452
187 WNT SIGNALING PATHWAY 17 351 1.822e-05 0.0004535
188 REGULATION OF TRANSMEMBRANE TRANSPORT 19 426 1.866e-05 0.000462
189 CELLULAR RESPONSE TO NITROGEN COMPOUND 21 505 1.937e-05 0.0004742
190 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 10 128 1.935e-05 0.0004742
191 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 11 156 1.963e-05 0.0004783
192 REGULATION OF CELL ADHESION 24 629 2.024e-05 0.0004906
193 REGULATION OF WNT SIGNALING PATHWAY PLANAR CELL POLARITY PATHWAY 4 12 2.036e-05 0.0004909
194 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 9 103 2.07e-05 0.0004966
195 REGULATION OF MAP KINASE ACTIVITY 16 319 2.102e-05 0.0005015
196 REGULATION OF GTPASE ACTIVITY 25 673 2.121e-05 0.0005034
197 RESPONSE TO HORMONE 30 893 2.152e-05 0.0005084
198 BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 5 24 2.206e-05 0.0005184
199 FOREBRAIN DEVELOPMENT 17 357 2.262e-05 0.000529
200 REGULATION OF RESPONSE TO STRESS 42 1468 2.307e-05 0.0005366
201 REGULATION OF CELL MORPHOGENESIS 22 552 2.347e-05 0.0005433
202 NEGATIVE REGULATION OF HYDROLASE ACTIVITY 18 397 2.497e-05 0.0005752
203 REGULATION OF TRANSFERASE ACTIVITY 31 946 2.513e-05 0.000576
204 REGULATION OF CELLULAR COMPONENT BIOGENESIS 27 767 2.538e-05 0.0005789
205 REGULATION OF FAT CELL DIFFERENTIATION 9 106 2.607e-05 0.0005918
206 STEM CELL PROLIFERATION 7 60 2.68e-05 0.0006053
207 ANION HOMEOSTASIS 6 41 2.744e-05 0.0006168
208 RESPONSE TO RETINOIC ACID 9 107 2.811e-05 0.0006288
209 POSITIVE REGULATION OF SYNAPSE ASSEMBLY 7 61 2.99e-05 0.0006656
210 REGULATION OF CELL ACTIVATION 20 484 3.347e-05 0.0007321
211 FOREBRAIN CELL MIGRATION 7 62 3.328e-05 0.0007321
212 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 18 406 3.352e-05 0.0007321
213 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 7 62 3.328e-05 0.0007321
214 PALATE DEVELOPMENT 8 85 3.495e-05 0.0007564
215 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 11 166 3.495e-05 0.0007564
216 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 12 197 3.563e-05 0.0007639
217 SECRETION BY CELL 20 486 3.546e-05 0.0007639
218 NEGATIVE REGULATION OF LOCOMOTION 14 263 3.616e-05 0.0007713
219 CEREBRAL CORTEX CELL MIGRATION 6 43 3.63e-05 0.0007713
220 RHYTHMIC PROCESS 15 298 3.652e-05 0.0007723
221 POSITIVE REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 4 14 4.023e-05 0.000845
222 AXIS ELONGATION 5 27 4.042e-05 0.000845
223 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 13 232 4.05e-05 0.000845
224 APPENDAGE DEVELOPMENT 11 169 4.12e-05 0.000852
225 LIMB DEVELOPMENT 11 169 4.12e-05 0.000852
226 REGULATION OF SYNAPSE ORGANIZATION 9 113 4.336e-05 0.0008927
227 NEGATIVE REGULATION OF CELL DEVELOPMENT 15 303 4.417e-05 0.0009054
228 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 8 88 4.494e-05 0.0009171
229 REGULATION OF BEHAVIOR 7 65 4.539e-05 0.0009182
230 CELLULAR RESPONSE TO RETINOIC ACID 7 65 4.539e-05 0.0009182
231 EXTRACELLULAR STRUCTURE ORGANIZATION 15 304 4.586e-05 0.0009238
232 CATION TRANSPORT 27 796 4.802e-05 0.0009632
233 REGULATION OF FATTY ACID OXIDATION 5 28 4.861e-05 0.0009654
234 REGULATION OF SPROUTING ANGIOGENESIS 5 28 4.861e-05 0.0009654
235 POST EMBRYONIC DEVELOPMENT 8 89 4.876e-05 0.0009654
236 IMMUNE SYSTEM DEVELOPMENT 22 582 5.181e-05 0.001022
237 SODIUM ION TRANSMEMBRANE TRANSPORT 8 90 5.285e-05 0.001029
238 ENDOTHELIUM DEVELOPMENT 8 90 5.285e-05 0.001029
239 POSITIVE REGULATION OF GROWTH 13 238 5.267e-05 0.001029
240 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 10 144 5.331e-05 0.001034
241 CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 4 15 5.423e-05 0.001047
242 SENSORY ORGAN MORPHOGENESIS 13 239 5.498e-05 0.001057
243 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 7 67 5.53e-05 0.001059
244 REGULATION OF WNT SIGNALING PATHWAY 15 310 5.725e-05 0.001092
245 POSITIVE REGULATION OF MAP KINASE ACTIVITY 12 207 5.766e-05 0.001095
246 SECRETION 22 588 6.025e-05 0.00114
247 CELL PART MORPHOGENESIS 23 633 6.387e-05 0.001203
248 REGULATION OF OSSIFICATION 11 178 6.604e-05 0.001239
249 HOMEOSTATIC PROCESS 38 1337 6.771e-05 0.001265
250 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 4 16 7.148e-05 0.00133
251 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 21 554 7.384e-05 0.001369
252 MUSCLE STRUCTURE DEVELOPMENT 18 432 7.457e-05 0.001377
253 RESPONSE TO ACID CHEMICAL 15 319 7.897e-05 0.001452
254 MONOVALENT INORGANIC CATION TRANSPORT 18 435 8.141e-05 0.001491
255 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 18 437 8.627e-05 0.001574
256 ENDOTHELIAL CELL DIFFERENTIATION 7 72 8.801e-05 0.0016
257 PALLIUM DEVELOPMENT 10 153 8.88e-05 0.001605
258 REGULATION OF CELLULAR RESPONSE TO STRESS 24 691 8.902e-05 0.001605
259 BRANCH ELONGATION OF AN EPITHELIUM 4 17 9.239e-05 0.001654
260 REGULATION OF ENERGY HOMEOSTASIS 4 17 9.239e-05 0.001654
261 REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 7 73 9.614e-05 0.001714
262 MEMORY 8 98 9.699e-05 0.00172
263 ARTERY MORPHOGENESIS 6 51 9.722e-05 0.00172
264 CELL CELL ADHESION 22 608 9.798e-05 0.001727
265 BONE DEVELOPMENT 10 156 0.0001044 0.001833
266 REGULATION OF SECRETION 24 699 0.0001061 0.001856
267 CIRCULATORY SYSTEM PROCESS 16 366 0.0001077 0.001878
268 INTRACELLULAR SIGNAL TRANSDUCTION 42 1572 0.0001093 0.001897
269 LEUKOCYTE DIFFERENTIATION 14 292 0.0001111 0.001922
270 POSITIVE REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 4 18 0.0001174 0.002024
271 MESENCHYME DEVELOPMENT 11 190 0.0001184 0.002032
272 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 6 53 0.0001209 0.002069
273 REGULATION OF BLOOD CIRCULATION 14 295 0.0001237 0.002108
274 ION HOMEOSTASIS 21 576 0.0001272 0.002159
275 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 8 102 0.0001285 0.002175
276 TRANSMISSION OF NERVE IMPULSE 6 54 0.0001344 0.002266
277 REGULATION OF BMP SIGNALING PATHWAY 7 77 0.000135 0.002268
278 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 13 262 0.0001387 0.002322
279 CONNECTIVE TISSUE DEVELOPMENT 11 194 0.0001423 0.002373
280 MAINTENANCE OF CELL NUMBER 9 132 0.0001447 0.002405
281 RESPONSE TO STEROID HORMONE 19 497 0.0001459 0.002415
282 RENAL TUBULE DEVELOPMENT 7 78 0.0001465 0.002417
283 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 8 104 0.0001472 0.002419
284 RESPONSE TO MONOAMINE 5 35 0.0001477 0.002419
285 CEREBRAL CORTEX DEVELOPMENT 8 105 0.0001573 0.00256
286 ODONTOGENESIS 8 105 0.0001573 0.00256
287 REGULATION OF DENDRITIC SPINE DEVELOPMENT 6 56 0.0001649 0.002673
288 REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 5 36 0.0001694 0.002728
289 POSITIVE CHEMOTAXIS 5 36 0.0001694 0.002728
290 LYMPHOCYTE ACTIVATION 15 342 0.0001701 0.002729
291 REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 6 57 0.000182 0.002881
292 ENDOTHELIAL CELL MIGRATION 6 57 0.000182 0.002881
293 REGULATION OF NEURON PROJECTION REGENERATION 4 20 0.0001817 0.002881
294 EYE MORPHOGENESIS 9 136 0.0001814 0.002881
295 HINDBRAIN DEVELOPMENT 9 137 0.0001918 0.003025
296 SKELETAL SYSTEM MORPHOGENESIS 11 201 0.000194 0.003049
297 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 12 236 0.0001991 0.003119
298 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 23 684 0.0002001 0.003124
299 WOUND HEALING 18 470 0.0002129 0.003313
300 POSITIVE REGULATION OF CELL ACTIVATION 14 311 0.0002139 0.003318
301 REGULATION OF ERK1 AND ERK2 CASCADE 12 238 0.0002152 0.003327
302 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 8 110 0.0002171 0.003345
303 POSITIVE REGULATION OF ORGAN GROWTH 5 38 0.0002203 0.003383
304 NEGATIVE REGULATION OF NEURON DEATH 10 171 0.0002215 0.003391
305 REGULATION OF SYNAPTIC PLASTICITY 9 140 0.0002256 0.003434
306 RESPONSE TO DRUG 17 431 0.0002258 0.003434
307 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 8 111 0.0002311 0.003502
308 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 7 84 0.0002331 0.00351
309 TISSUE MIGRATION 7 84 0.0002331 0.00351
310 REGULATION OF CELLULAR KETONE METABOLIC PROCESS 10 173 0.0002433 0.003652
311 REGULATION OF OSTEOBLAST DIFFERENTIATION 8 112 0.0002457 0.003676
312 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 13 278 0.000248 0.003699
313 NEGATIVE CHEMOTAXIS 5 39 0.0002497 0.003712
314 ACTIVATION OF PROTEIN KINASE ACTIVITY 13 279 0.0002568 0.003805
315 OVULATION CYCLE 8 113 0.0002611 0.003857
316 CELLULAR RESPONSE TO ACID CHEMICAL 10 175 0.0002669 0.003922
317 CEREBELLAR CORTEX FORMATION 4 22 0.000268 0.003922
318 AORTA MORPHOGENESIS 4 22 0.000268 0.003922
319 LYMPHOCYTE DIFFERENTIATION 11 209 0.0002718 0.003965
320 REGULATION OF EMBRYONIC DEVELOPMENT 8 114 0.0002773 0.004033
321 SODIUM ION TRANSPORT 9 144 0.0002784 0.004036
322 FORELIMB MORPHOGENESIS 5 40 0.000282 0.004074
323 REGULATION OF FATTY ACID METABOLIC PROCESS 7 87 0.0002897 0.004173
324 NEGATIVE REGULATION OF MAPK CASCADE 9 145 0.0002931 0.00421
325 OVULATION CYCLE PROCESS 7 88 0.0003109 0.004437
326 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 7 88 0.0003109 0.004437
327 FEMALE SEX DIFFERENTIATION 8 116 0.0003122 0.004442
328 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 5 41 0.0003173 0.00446
329 AORTA DEVELOPMENT 5 41 0.0003173 0.00446
330 NEGATIVE REGULATION OF STRESS ACTIVATED MAPK CASCADE 5 41 0.0003173 0.00446
331 NEGATIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 41 0.0003173 0.00446
332 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 16 404 0.0003289 0.004609
333 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 8 117 0.0003309 0.004624
334 EPITHELIAL CELL PROLIFERATION 7 89 0.0003332 0.004642
335 NEUROLOGICAL SYSTEM PROCESS 34 1242 0.000336 0.004667
336 DIGESTIVE SYSTEM DEVELOPMENT 9 148 0.0003411 0.004723
337 REGULATION OF PHOSPHOLIPASE ACTIVITY 6 64 0.0003452 0.004752
338 REGULATION OF NEUROTRANSMITTER TRANSPORT 6 64 0.0003452 0.004752
339 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 5 42 0.0003559 0.004885
340 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 11 216 0.0003601 0.004928
341 REPRODUCTIVE SYSTEM DEVELOPMENT 16 408 0.0003665 0.004987
342 REGULATION OF PROTEIN LOCALIZATION 28 950 0.0003655 0.004987
343 POSITIVE REGULATION OF HYDROLASE ACTIVITY 27 905 0.0003863 0.00524
344 METAL ION TRANSPORT 20 582 0.0003952 0.005346
345 CELL FATE DETERMINATION 5 43 0.000398 0.005353
346 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 10 184 0.000398 0.005353
347 NEPHRON EPITHELIUM DEVELOPMENT 7 93 0.000436 0.005829
348 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 9 153 0.0004353 0.005829
349 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 8 122 0.0004388 0.005851
350 NEURON FATE COMMITMENT 6 67 0.000443 0.005872
351 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 6 67 0.000443 0.005872
352 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 23 724 0.0004463 0.005899
353 SINGLE ORGANISM CELL ADHESION 17 459 0.0004657 0.006138
354 NEGATIVE REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 11 0.0004707 0.006169
355 REGULATION OF CYTOKINE SECRETION INVOLVED IN IMMUNE RESPONSE 3 11 0.0004707 0.006169
356 PATTERN SPECIFICATION PROCESS 16 418 0.0004774 0.006239
357 ORGAN GROWTH 6 68 0.00048 0.006256
358 NEGATIVE REGULATION OF RESPONSE TO WOUNDING 9 156 0.0005014 0.006517
359 REGULATION OF NEUROTRANSMITTER LEVELS 10 190 0.0005123 0.00664
360 NEGATIVE REGULATION OF OSSIFICATION 6 69 0.0005193 0.006693
361 SYNAPSE ASSEMBLY 6 69 0.0005193 0.006693
362 REGULATION OF MACROPHAGE ACTIVATION 4 26 0.0005231 0.006724
363 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 10 191 0.0005337 0.006842
364 REGULATION OF CELLULAR LOCALIZATION 34 1277 0.0005522 0.007059
365 GLAND MORPHOGENESIS 7 97 0.0005626 0.007152
366 MUSCLE ORGAN MORPHOGENESIS 6 70 0.0005611 0.007152
367 NEGATIVE REGULATION OF MOLECULAR FUNCTION 30 1079 0.0005924 0.007511
368 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 7 98 0.0005984 0.007546
369 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 7 98 0.0005984 0.007546
370 EXCITATORY POSTSYNAPTIC POTENTIAL 4 27 0.0006071 0.007634
371 EMBRYONIC CAMERA TYPE EYE FORMATION 3 12 0.0006207 0.007785
372 POSITIVE REGULATION OF TRANSPORT 27 936 0.0006461 0.008082
373 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 162 0.0006586 0.008215
374 METENCEPHALON DEVELOPMENT 7 100 0.0006755 0.008404
375 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 10 197 0.0006787 0.008421
376 POSITIVE REGULATION OF PROTEIN BINDING 6 73 0.0007023 0.008578
377 PANCREAS DEVELOPMENT 6 73 0.0007023 0.008578
378 REGULATION OF ORGAN GROWTH 6 73 0.0007023 0.008578
379 REGULATION OF CELL GROWTH 15 391 0.0006966 0.008578
380 LEARNING 8 131 0.0007042 0.008578
381 REGULATION OF KERATINOCYTE PROLIFERATION 4 28 0.0007002 0.008578
382 RETINA DEVELOPMENT IN CAMERA TYPE EYE 8 131 0.0007042 0.008578
383 REGULATION OF EXTENT OF CELL GROWTH 7 101 0.0007168 0.008668
384 CAMERA TYPE EYE MORPHOGENESIS 7 101 0.0007168 0.008668
385 REGIONALIZATION 13 311 0.0007172 0.008668
386 REGULATION OF HORMONE LEVELS 17 478 0.0007328 0.008834
387 RESPONSE TO OXIDATIVE STRESS 14 352 0.0007366 0.008856
388 REGULATION OF IMMUNE SYSTEM PROCESS 36 1403 0.0007421 0.0089
389 RESPONSE TO INORGANIC SUBSTANCE 17 479 0.00075 0.008971
390 CELLULAR RESPONSE TO PEPTIDE 12 274 0.0007615 0.009085
391 GLAND DEVELOPMENT 15 395 0.0007726 0.009194
392 MUSCLE TISSUE DEVELOPMENT 12 275 0.0007861 0.00933
393 HEMATOPOIETIC STEM CELL PROLIFERATION 3 13 0.0007983 0.009403
394 DIVALENT INORGANIC ANION HOMEOSTASIS 3 13 0.0007983 0.009403
395 POSITIVE REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 3 13 0.0007983 0.009403
396 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 4 29 0.0008029 0.009434
397 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 5 50 0.0008058 0.009445
398 ARTERY DEVELOPMENT 6 75 0.0008108 0.009479
NumGOOverlapSizeP ValueAdj. P Value
1 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 47 1199 6.145e-10 5.708e-07
2 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 22 328 3.525e-09 1.637e-06
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 29 629 5.53e-08 1.291e-05
4 RECEPTOR BINDING 49 1476 5.559e-08 1.291e-05
5 VOLTAGE GATED SODIUM CHANNEL ACTIVITY 6 20 3.063e-07 5.692e-05
6 REGULATORY REGION NUCLEIC ACID BINDING 32 818 4.601e-07 7.123e-05
7 SODIUM CHANNEL ACTIVITY 7 37 9.525e-07 0.0001264
8 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 15 226 1.315e-06 0.0001486
9 SEQUENCE SPECIFIC DNA BINDING 36 1037 1.44e-06 0.0001486
10 CATION CHANNEL ACTIVITY 17 298 2.103e-06 0.0001954
11 MOLECULAR FUNCTION REGULATOR 42 1353 3.188e-06 0.0002692
12 VOLTAGE GATED ION CHANNEL ACTIVITY 13 190 4.825e-06 0.0003735
13 SIGNAL TRANSDUCER ACTIVITY 49 1731 5.786e-06 0.0004135
14 GATED CHANNEL ACTIVITY 17 325 6.707e-06 0.0004451
15 DOUBLE STRANDED DNA BINDING 28 764 8.567e-06 0.0005306
16 PROTEIN DIMERIZATION ACTIVITY 35 1149 3.379e-05 0.001962
17 CORE PROMOTER PROXIMAL REGION DNA BINDING 17 371 3.676e-05 0.002009
18 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 11 168 3.902e-05 0.002014
19 PASSIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 19 464 5.945e-05 0.002907
20 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 15 315 6.856e-05 0.003185
21 IDENTICAL PROTEIN BINDING 35 1209 9.374e-05 0.004147
22 GROWTH FACTOR RECEPTOR BINDING 9 129 0.0001214 0.005127
23 GROWTH FACTOR ACTIVITY 10 160 0.0001287 0.005199
24 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 12 228 0.0001445 0.005592
25 INTEGRIN BINDING 8 105 0.0001573 0.005622
26 RECEPTOR ACTIVITY 43 1649 0.0001539 0.005622
27 PROTEIN HOMODIMERIZATION ACTIVITY 24 722 0.0001727 0.005944
28 STEROID HORMONE RECEPTOR ACTIVITY 6 59 0.0002205 0.007317
NumGOOverlapSizeP ValueAdj. P Value
1 SYNAPSE 37 754 1.22e-10 7.123e-08
2 EXCITATORY SYNAPSE 17 197 5.449e-09 1.427e-06
3 POSTSYNAPSE 23 378 9.776e-09 1.427e-06
4 SYNAPSE PART 30 610 7.528e-09 1.427e-06
5 INTRINSIC COMPONENT OF PLASMA MEMBRANE 53 1649 4.192e-08 4.712e-06
6 NEURON PROJECTION 37 942 4.841e-08 4.712e-06
7 EXTRACELLULAR MATRIX 23 426 8.8e-08 7.342e-06
8 CELL JUNCTION 41 1151 1.241e-07 9.061e-06
9 NEURON PART 43 1265 2.154e-07 1.315e-05
10 CELL PROJECTION 54 1786 2.252e-07 1.315e-05
11 PROTEINACEOUS EXTRACELLULAR MATRIX 20 356 3.342e-07 1.774e-05
12 VOLTAGE GATED SODIUM CHANNEL COMPLEX 5 14 1.172e-06 5.702e-05
13 EXTRACELLULAR SPACE 43 1376 2.017e-06 9.063e-05
14 SODIUM CHANNEL COMPLEX 5 17 3.493e-06 0.0001457
15 TRANSPORTER COMPLEX 17 321 5.696e-06 0.0002218
16 CATION CHANNEL COMPLEX 12 167 6.797e-06 0.0002481
17 SITE OF POLARIZED GROWTH 11 149 1.275e-05 0.0004379
18 SOMATODENDRITIC COMPARTMENT 24 650 3.427e-05 0.001112
19 PRESYNAPSE 14 283 7.976e-05 0.002452
20 EXTRACELLULAR MATRIX COMPONENT 9 125 9.533e-05 0.002783
21 RECEPTOR COMPLEX 15 327 0.000104 0.002893
22 CELL PROJECTION PART 29 946 0.0001485 0.003941
23 PLASMA MEMBRANE PROTEIN COMPLEX 19 510 0.0002027 0.005147
24 EXOCYTIC VESICLE 9 142 0.0002509 0.006105
25 MEMBRANE REGION 32 1134 0.0002995 0.006996
26 BASEMENT MEMBRANE 7 93 0.000436 0.009793

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 11 139 6.568e-06 0.0003415
2 MAPK_signaling_pathway_hsa04010 14 295 0.0001237 0.003082
3 Focal_adhesion_hsa04510 11 199 0.0001778 0.003082
4 Rap1_signaling_pathway_hsa04015 11 206 0.00024 0.00312
5 Hippo_signaling_pathway_hsa04390 9 154 0.0004565 0.004748
6 ECM_receptor_interaction_hsa04512 6 82 0.001295 0.01056
7 Wnt_signaling_pathway_hsa04310 8 146 0.001421 0.01056
8 PI3K_Akt_signaling_pathway_hsa04151 12 352 0.005975 0.03853
9 Cytokine_cytokine_receptor_interaction_hsa04060 10 270 0.0067 0.03853
10 Ras_signaling_pathway_hsa04014 9 232 0.007409 0.03853
11 Calcium_signaling_pathway_hsa04020 7 182 0.01802 0.08518
12 Phospholipase_D_signaling_pathway_hsa04072 6 146 0.02075 0.08531
13 Adherens_junction_hsa04520 4 72 0.02133 0.08531
14 ABC_transporters_hsa02010 3 45 0.02809 0.101
15 Hedgehog_signaling_pathway_hsa04340 3 47 0.03143 0.101
16 Notch_signaling_pathway_hsa04330 3 48 0.03317 0.101
17 cGMP_PKG_signaling_pathway_hsa04022 6 163 0.03319 0.101
18 TGF_beta_signaling_pathway_hsa04350 4 84 0.03497 0.101
19 FoxO_signaling_pathway_hsa04068 5 132 0.04502 0.1232
20 Neuroactive_ligand_receptor_interaction_hsa04080 8 278 0.05295 0.1377
21 Cell_adhesion_molecules_.CAMs._hsa04514 5 145 0.06246 0.1547
22 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.06702 0.1556
23 mTOR_signaling_pathway_hsa04150 5 151 0.07163 0.1556
24 cAMP_signaling_pathway_hsa04024 6 198 0.0718 0.1556
25 p53_signaling_pathway_hsa04115 3 68 0.07792 0.1621
26 Regulation_of_actin_cytoskeleton_hsa04810 6 208 0.08619 0.1724
27 Jak_STAT_signaling_pathway_hsa04630 5 162 0.09025 0.1738
28 AMPK_signaling_pathway_hsa04152 4 121 0.1023 0.19
29 Gap_junction_hsa04540 3 88 0.1388 0.2489
30 Cellular_senescence_hsa04218 4 160 0.2081 0.3538
31 TNF_signaling_pathway_hsa04668 3 108 0.2109 0.3538
32 Cell_cycle_hsa04110 3 124 0.2733 0.4441
33 Apelin_signaling_pathway_hsa04371 3 137 0.3252 0.5125
34 Peroxisome_hsa04146 2 83 0.3439 0.5259
35 HIF_1_signaling_pathway_hsa04066 2 100 0.4319 0.6417
36 Tight_junction_hsa04530 3 170 0.4552 0.6575
37 Endocytosis_hsa04144 4 244 0.481 0.676
38 Sphingolipid_signaling_pathway_hsa04071 2 118 0.5179 0.7087

Quest ID: 0f430d422a8584194e2c81d38f5dbd3d