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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-150-5p ACVR1B -0.11 0.79935 0.35 0.04863 miRNATAP -0.11 0 NA
2 hsa-miR-150-5p ARHGEF10L -0.11 0.79935 -0.23 0.32891 miRNATAP -0.11 3.0E-5 NA
3 hsa-miR-150-5p C6orf223 -0.11 0.79935 2.63 4.0E-5 mirMAP -0.25 0.00073 NA
4 hsa-miR-150-5p CA12 -0.11 0.79935 -0.95 0.06698 mirMAP -0.2 0.0008 NA
5 hsa-miR-150-5p CACNA1D -0.11 0.79935 -0.49 0.50057 MirTarget -0.21 0.0112 NA
6 hsa-miR-150-5p CACNB3 -0.11 0.79935 1.08 0 miRNATAP -0.14 0 NA
7 hsa-miR-150-5p DLX6 -0.11 0.79935 2.58 2.0E-5 MirTarget -0.19 0.00639 NA
8 hsa-miR-150-5p EDA -0.11 0.79935 -1.83 3.0E-5 miRNATAP -0.16 0.00217 NA
9 hsa-miR-150-5p EFNB1 -0.11 0.79935 -0.05 0.87748 miRNATAP -0.11 0.00164 NA
10 hsa-miR-150-5p FAM155B -0.11 0.79935 0.33 0.62453 mirMAP -0.25 0.00105 NA
11 hsa-miR-150-5p FNDC5 -0.11 0.79935 -1.42 0.00016 miRNATAP -0.12 0.00505 NA
12 hsa-miR-150-5p GSTM3 -0.11 0.79935 -1.36 0.01678 mirMAP -0.25 0.00014 NA
13 hsa-miR-150-5p KBTBD12 -0.11 0.79935 -3.03 5.0E-5 mirMAP -0.21 0.02 NA
14 hsa-miR-150-5p KIAA0895L -0.11 0.79935 0.67 0.00284 MirTarget -0.16 0 NA
15 hsa-miR-150-5p KLHDC7A -0.11 0.79935 1.56 0.09214 MirTarget -0.22 0.04021 NA
16 hsa-miR-150-5p KSR2 -0.11 0.79935 1.26 0.07396 mirMAP -0.21 0.01197 NA
17 hsa-miR-150-5p LRAT -0.11 0.79935 -0.54 0.47405 MirTarget -0.23 0.00888 NA
18 hsa-miR-150-5p MAPT -0.11 0.79935 -2.58 0 mirMAP -0.18 0.00076 NA
19 hsa-miR-150-5p MEX3A -0.11 0.79935 3.12 0 MirTarget -0.19 0.00012 NA
20 hsa-miR-150-5p MTSS1L -0.11 0.79935 -0.35 0.10973 mirMAP -0.11 1.0E-5 NA
21 hsa-miR-150-5p MUM1L1 -0.11 0.79935 0.53 0.39424 MirTarget -0.19 0.00954 NA
22 hsa-miR-150-5p NDRG4 -0.11 0.79935 0.39 0.35138 mirMAP -0.27 0 NA
23 hsa-miR-150-5p NEIL1 -0.11 0.79935 0.44 0.14265 MirTarget -0.11 0.00222 NA
24 hsa-miR-150-5p NEO1 -0.11 0.79935 -0.77 0.00728 mirMAP -0.11 0.00133 NA
25 hsa-miR-150-5p OBSCN -0.11 0.79935 -0.08 0.80484 mirMAP -0.13 0.00088 NA
26 hsa-miR-150-5p PBX1 -0.11 0.79935 -1.67 0 mirMAP -0.13 0.00033 NA
27 hsa-miR-150-5p PCGF3 -0.11 0.79935 0.64 0.00032 mirMAP -0.11 0 NA
28 hsa-miR-150-5p PFN2 -0.11 0.79935 0.33 0.19078 miRNATAP -0.11 0.00026 NA
29 hsa-miR-150-5p POU2F1 -0.11 0.79935 -0.09 0.73364 mirMAP; miRNATAP -0.12 0.0001 NA
30 hsa-miR-150-5p PRKCA -0.11 0.79935 -1.04 0.00033 mirMAP -0.12 0.00023 NA
31 hsa-miR-150-5p PSD3 -0.11 0.79935 -0.2 0.45901 mirMAP -0.12 0.0001 NA
32 hsa-miR-150-5p PTPRR -0.11 0.79935 1.76 0.01211 miRNAWalker2 validate -0.25 0.0024 NA
33 hsa-miR-150-5p RAB40B -0.11 0.79935 -0.53 0.00689 mirMAP -0.11 0 NA
34 hsa-miR-150-5p SHISA4 -0.11 0.79935 0.11 0.63485 miRNATAP -0.1 0.00026 NA
35 hsa-miR-150-5p SSTR5 -0.11 0.79935 -0.93 0.10643 mirMAP -0.2 0.00315 NA
36 hsa-miR-150-5p TNNI1 -0.11 0.79935 2.05 0 mirMAP -0.12 0.00879 NA
37 hsa-miR-150-5p TRIM9 -0.11 0.79935 0.25 0.60043 MirTarget -0.15 0.00667 NA
38 hsa-miR-150-5p UGT1A3 -0.11 0.79935 1.15 0.04636 MirTarget -0.18 0.00705 NA
39 hsa-miR-150-5p VEGFA -0.11 0.79935 0.47 0.09899 miRNAWalker2 validate; miRTarBase -0.16 0 NA
40 hsa-miR-150-5p ZNF704 -0.11 0.79935 -1.33 0.00056 mirMAP -0.13 0.00454 NA
41 hsa-miR-150-5p ZNF711 -0.11 0.79935 0.05 0.90676 MirTarget -0.16 0.0005 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 6 295 2.851e-05 0.001482
2 VEGF_signaling_pathway_hsa04370 2 59 0.006516 0.1492
3 Rap1_signaling_pathway_hsa04015 3 206 0.00861 0.1492
4 Ras_signaling_pathway_hsa04014 3 232 0.01188 0.1544
5 Cytokine_cytokine_receptor_interaction_hsa04060 3 270 0.01778 0.155
6 HIF_1_signaling_pathway_hsa04066 2 100 0.01788 0.155
7 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.03296 0.2448
8 Calcium_signaling_pathway_hsa04020 2 182 0.05358 0.3261
9 cAMP_signaling_pathway_hsa04024 2 198 0.06217 0.3261
10 Focal_adhesion_hsa04510 2 199 0.06272 0.3261
11 PI3K_Akt_signaling_pathway_hsa04151 2 352 0.1624 0.6149

Quest ID: 101960d94a023d28424965e5363775a9