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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-224-5p ABCC5 -2.66 0 0.67 0.21962 mirMAP -0.12 0 NA
2 hsa-miR-224-5p ABHD2 -2.66 0 1.06 0.12031 mirMAP -0.14 0 NA
3 hsa-miR-452-5p ABHD2 -2.02 0.00026 1.06 0.12031 mirMAP -0.22 0 NA
4 hsa-miR-18a-5p ABR -2.3 0 0.31 0.60278 miRNAWalker2 validate; mirMAP -0.11 0 NA
5 hsa-miR-224-5p ACSS1 -2.66 0 0.51 0.33926 MirTarget -0.16 0 NA
6 hsa-miR-452-5p ACSS1 -2.02 0.00026 0.51 0.33926 MirTarget -0.16 0 NA
7 hsa-miR-18a-5p ADAMTS2 -2.3 0 0.29 0.51167 mirMAP -0.15 0 NA
8 hsa-miR-224-5p AFF3 -2.66 0 4 0 MirTarget -0.49 0 NA
9 hsa-miR-18a-5p AFF4 -2.3 0 0.7 0.2756 miRNAWalker2 validate -0.22 0 NA
10 hsa-miR-224-5p AGBL4 -2.66 0 1.65 0 mirMAP -0.2 0 NA
11 hsa-miR-18a-5p ALCAM -2.3 0 1.44 0.0323 MirTarget; miRNATAP -0.34 0 NA
12 hsa-miR-224-5p AMN1 -2.66 0 0.48 0.12341 MirTarget -0.11 0 NA
13 hsa-miR-224-5p AMZ1 -2.66 0 1.47 0 mirMAP -0.23 0 NA
14 hsa-miR-18a-5p ANKRD50 -2.3 0 0.73 0.17675 MirTarget; miRNATAP -0.18 0 NA
15 hsa-miR-452-5p ANKS1B -2.02 0.00026 1.36 0 miRNATAP -0.29 0 NA
16 hsa-miR-18a-5p APOLD1 -2.3 0 0.38 0.4521 mirMAP -0.16 0 NA
17 hsa-miR-18a-5p ARFGEF2 -2.3 0 0.4 0.50575 MirTarget -0.12 0 NA
18 hsa-miR-18a-5p ARHGAP5 -2.3 0 0.05 0.93513 MirTarget -0.12 0 NA
19 hsa-miR-452-5p ARID2 -2.02 0.00026 0.69 0.16232 MirTarget -0.14 0 NA
20 hsa-miR-18a-5p ARL15 -2.3 0 0.82 0.02217 MirTarget; miRNATAP -0.26 0 NA
21 hsa-miR-224-5p ARMCX2 -2.66 0 0.5 0.33207 MirTarget -0.11 0 NA
22 hsa-miR-452-5p ASAH1 -2.02 0.00026 1 0.17531 MirTarget -0.1 0 NA
23 hsa-miR-18a-5p ASTN1 -2.3 0 -0.11 0.73119 MirTarget -0.25 0 NA
24 hsa-miR-18a-5p ASXL2 -2.3 0 0.04 0.92196 miRNATAP -0.17 0 NA
25 hsa-miR-18a-5p ATF7 -2.3 0 0.31 0.57742 mirMAP -0.14 0 NA
26 hsa-miR-18a-5p ATM -2.3 0 0.05 0.92324 miRNAWalker2 validate; miRTarBase; MirTarget -0.12 0 23857602; 23437304; 25963391; 23229340 Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases
27 hsa-miR-18a-5p ATP1B2 -2.3 0 0.53 0.01045 mirMAP -0.23 0 NA
28 hsa-miR-18a-5p ATP2B1 -2.3 0 0.32 0.5434 miRNATAP -0.12 0 NA
29 hsa-miR-18a-5p ATP2C2 -2.3 0 0.99 0.0117 MirTarget -0.2 0 NA
30 hsa-miR-18a-5p ATXN1 -2.3 0 0.48 0.35126 MirTarget; miRNATAP -0.16 0 NA
31 hsa-miR-18a-5p BBX -2.3 0 0.06 0.91654 MirTarget; miRNATAP -0.11 0 NA
32 hsa-miR-452-5p BCAS1 -2.02 0.00026 4.85 0 mirMAP -0.65 0 NA
33 hsa-miR-224-5p BCL2 -2.66 0 1.88 0.00098 mirMAP -0.24 0 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01
34 hsa-miR-452-5p BCL2 -2.02 0.00026 1.88 0.00098 mirMAP -0.28 0 NA
35 hsa-miR-18a-5p BHLHE22 -2.3 0 -0.39 0.0481 MirTarget; miRNATAP -0.1 0.00101 NA
36 hsa-miR-224-5p BTRC -2.66 0 0.93 0.05784 MirTarget -0.13 0 NA
37 hsa-miR-452-5p BZW1 -2.02 0.00026 0.47 0.51928 MirTarget; miRNATAP -0.11 0 NA
38 hsa-miR-18a-5p C1orf21 -2.3 0 1.31 0.03763 mirMAP -0.35 0 NA
39 hsa-miR-224-5p C1orf21 -2.66 0 1.31 0.03763 mirMAP -0.13 0 NA
40 hsa-miR-452-5p C1orf21 -2.02 0.00026 1.31 0.03763 mirMAP -0.13 0 NA
41 hsa-miR-18a-5p C1orf226 -2.3 0 0.84 0.08628 mirMAP -0.29 0 NA
42 hsa-miR-18a-5p C5orf30 -2.3 0 1.64 0.00035 miRNATAP -0.22 0 NA
43 hsa-miR-18a-5p CA12 -2.3 0 4.61 0 miRNAWalker2 validate; MirTarget -0.85 0 NA
44 hsa-miR-18a-5p CACNG4 -2.3 0 3.36 0 mirMAP -0.48 0 NA
45 hsa-miR-224-5p CADM2 -2.66 0 2.36 0 mirMAP -0.16 1.0E-5 NA
46 hsa-miR-452-5p CADM2 -2.02 0.00026 2.36 0 MirTarget -0.13 0.00422 NA
47 hsa-miR-18a-5p CALN1 -2.3 0 1.14 0.00178 mirMAP -0.42 0 NA
48 hsa-miR-18a-5p CAMK2B -2.3 0 1.56 0 mirMAP -0.27 0 NA
49 hsa-miR-18a-5p CAMK2N1 -2.3 0 1.69 0.00251 miRNATAP -0.3 0 NA
50 hsa-miR-452-5p CASC1 -2.02 0.00026 2.56 0 MirTarget -0.45 0 NA
51 hsa-miR-452-5p CASD1 -2.02 0.00026 0.96 0.05329 MirTarget; miRNATAP -0.16 0 NA
52 hsa-miR-18a-5p CASZ1 -2.3 0 0.88 0.0914 mirMAP -0.22 0 NA
53 hsa-miR-224-5p CCNG2 -2.66 0 1.09 0.07868 mirMAP -0.12 0 NA
54 hsa-miR-452-5p CCNO -2.02 0.00026 1.97 0 MirTarget -0.27 0 NA
55 hsa-miR-452-5p CDH2 -2.02 0.00026 0.03 0.91735 miRNATAP -0.14 4.0E-5 NA
56 hsa-miR-18a-5p CDON -2.3 0 0.93 0.03701 mirMAP -0.27 0 NA
57 hsa-miR-452-5p CDON -2.02 0.00026 0.93 0.03701 mirMAP -0.11 0 NA
58 hsa-miR-18a-5p CLASP2 -2.3 0 0.44 0.39581 miRNATAP -0.14 0 NA
59 hsa-miR-224-5p COQ7 -2.66 0 0.87 0.0466 mirMAP -0.11 0 NA
60 hsa-miR-18a-5p CREBL2 -2.3 0 0.55 0.34569 miRNAWalker2 validate; MirTarget; miRNATAP -0.19 0 NA
61 hsa-miR-18a-5p CRIM1 -2.3 0 0.31 0.6343 MirTarget; miRNATAP -0.27 0 NA
62 hsa-miR-452-5p CSMD3 -2.02 0.00026 1.2 0.03461 MirTarget -0.22 0 NA
63 hsa-miR-18a-5p CSNK1G1 -2.3 0 0.46 0.31306 mirMAP -0.11 0 NA
64 hsa-miR-18a-5p CSRNP3 -2.3 0 0.3 0.37119 miRNAWalker2 validate; miRNATAP -0.36 0 NA
65 hsa-miR-452-5p CST1 -2.02 0.00026 1.36 0.00826 MirTarget -0.67 0 NA
66 hsa-miR-452-5p CST5 -2.02 0.00026 3.37 0 MirTarget -0.75 0 NA
67 hsa-miR-18a-5p CTDSPL -2.3 0 0.41 0.46081 miRNAWalker2 validate; MirTarget; miRNATAP -0.16 0 NA
68 hsa-miR-18a-5p CTGF -2.3 0 0.22 0.78118 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.12 2.0E-5 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling
69 hsa-miR-224-5p CXXC4 -2.66 0 1.31 0 MirTarget -0.18 0 NA
70 hsa-miR-452-5p CXXC4 -2.02 0.00026 1.31 0 miRNATAP -0.23 0 NA
71 hsa-miR-18a-5p CYP4F11 -2.3 0 2.83 0 MirTarget -0.61 0 NA
72 hsa-miR-18a-5p DAAM2 -2.3 0 0.04 0.92488 miRNAWalker2 validate -0.13 0 NA
73 hsa-miR-452-5p DACH1 -2.02 0.00026 4.05 0 mirMAP -0.51 0 NA
74 hsa-miR-452-5p DCTN4 -2.02 0.00026 0.76 0.19771 mirMAP -0.12 0 NA
75 hsa-miR-18a-5p DCUN1D3 -2.3 0 0.21 0.50418 miRNAWalker2 validate -0.12 0 NA
76 hsa-miR-452-5p DENND1B -2.02 0.00026 0.37 0.19669 mirMAP -0.15 0 NA
77 hsa-miR-452-5p DHX40 -2.02 0.00026 0.61 0.27609 MirTarget -0.11 0 NA
78 hsa-miR-18a-5p DICER1 -2.3 0 0.3 0.60913 miRNAWalker2 validate -0.14 0 27338043; 21935572 MiR 18a upregulation decreases Dicer expression and confers paclitaxel resistance in triple negative breast cancer; In this study we investigated the association among miR-18a dysregulation Dicer dysregulation and paclitaxel PTX resistance in TNBC cells; The influence of miR-18a overexpression on Dicer expression was measured by qRT-PCR and Western blot analysis; MiR-18a overexpression directly led to Dicer repression at mRNA and protein level; This study found that miR-18a is an important miRNA that suppresses Dicer expression and increases PTX resistance in TNBC cells;microRNA 18a a member of the oncogenic miR 17 92 cluster targets Dicer and suppresses cell proliferation in bladder cancer T24 cells; Furthermore ectopic expression of miR-18a in T24 cells down-regulated Dicer expression at both the mRNA and protein level while inhibition miR-18a by antisense oligonucleotides could enhance Dicer expression in T24 cells; Two binding sites of miR-18a were found in Dicer 3' untranslated region 3' UTR; In addition knockdown of Dicer expression by siRNA mimicked cell growth suppression induced by miR-18a in T24 cells; These results show that miR-18a functions as a tumor suppressor by targeting Dicer in bladder cancer T24 cells and revealed a noteworthy feedback loop which may be utilized by the miR-17-92 cluster to control miRNA output and prevent its overexpression
79 hsa-miR-224-5p DIO1 -2.66 0 3.83 0 miRTarBase -0.35 0 NA
80 hsa-miR-18a-5p DNAJC16 -2.3 0 0.57 0.21774 MirTarget -0.15 0 NA
81 hsa-miR-224-5p DNMBP -2.66 0 1.14 0.0157 MirTarget -0.13 0 NA
82 hsa-miR-18a-5p DOCK4 -2.3 0 -0.07 0.86467 MirTarget -0.11 0 NA
83 hsa-miR-18a-5p DPY19L3 -2.3 0 0.54 0.15711 MirTarget -0.18 0 NA
84 hsa-miR-452-5p DPY19L3 -2.02 0.00026 0.54 0.15711 mirMAP -0.12 0 NA
85 hsa-miR-18a-5p DST -2.3 0 -0.02 0.98236 mirMAP -0.25 0 NA
86 hsa-miR-452-5p DUSP4 -2.02 0.00026 1.65 0.00224 mirMAP -0.17 0 NA
87 hsa-miR-224-5p EFR3B -2.66 0 0.91 0.00161 MirTarget -0.17 0 NA
88 hsa-miR-452-5p ELAVL2 -2.02 0.00026 -1.04 5.0E-5 MirTarget; miRNATAP -0.14 0.00012 NA
89 hsa-miR-452-5p ELFN2 -2.02 0.00026 1.36 5.0E-5 miRNATAP -0.1 0.01262 NA
90 hsa-miR-452-5p ELOVL5 -2.02 0.00026 1.45 0.05049 MirTarget -0.16 0 NA
91 hsa-miR-452-5p ERBB4 -2.02 0.00026 5.37 0 mirMAP -0.7 0 NA
92 hsa-miR-18a-5p ESR1 -2.3 0 6.15 0 miRNAWalker2 validate; miRTarBase; miRNATAP -1.14 0 19027010; 24975878 MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation
93 hsa-miR-18a-5p F3 -2.3 0 0.07 0.88241 MirTarget -0.22 0 NA
94 hsa-miR-18a-5p FAIM2 -2.3 0 1.17 0.0002 mirMAP -0.37 0 NA
95 hsa-miR-224-5p FAM135B -2.66 0 2.43 0 MirTarget -0.31 0 NA
96 hsa-miR-18a-5p FAM166B -2.3 0 0.21 0.42685 MirTarget -0.14 0.00112 NA
97 hsa-miR-18a-5p FAM168A -2.3 0 0.04 0.90735 mirMAP -0.12 0 NA
98 hsa-miR-224-5p FAM177B -2.66 0 1.4 0.00023 MirTarget -0.15 2.0E-5 NA
99 hsa-miR-18a-5p FAM196A -2.3 0 2.86 0 MirTarget -0.56 0 NA
100 hsa-miR-452-5p FAM196A -2.02 0.00026 2.86 0 mirMAP -0.61 0 NA
101 hsa-miR-224-5p FAM46C -2.66 0 1.01 0.03653 MirTarget -0.12 0 NA
102 hsa-miR-18a-5p FBP1 -2.3 0 2.6 0 MirTarget -0.5 0 NA
103 hsa-miR-18a-5p FEM1C -2.3 0 0.62 0.20954 miRNAWalker2 validate -0.17 0 NA
104 hsa-miR-18a-5p FGF1 -2.3 0 0.65 0.10119 MirTarget -0.31 0 NA
105 hsa-miR-18a-5p FNDC3A -2.3 0 0.25 0.65712 miRNATAP -0.15 0 NA
106 hsa-miR-18a-5p FRS2 -2.3 0 1.13 0.03077 MirTarget -0.26 0 NA
107 hsa-miR-18a-5p FRYL -2.3 0 0.45 0.40277 miRNATAP -0.15 0 NA
108 hsa-miR-18a-5p GAB1 -2.3 0 0.51 0.28626 MirTarget; miRNATAP -0.18 0 NA
109 hsa-miR-452-5p GARNL3 -2.02 0.00026 0.72 0.01602 MirTarget -0.11 0 NA
110 hsa-miR-18a-5p GAS7 -2.3 0 0.45 0.39346 mirMAP -0.26 0 NA
111 hsa-miR-452-5p GFRA1 -2.02 0.00026 4.85 0 MirTarget -0.6 0 NA
112 hsa-miR-452-5p GIN1 -2.02 0.00026 0.76 0.00309 MirTarget -0.12 0 NA
113 hsa-miR-452-5p GLCCI1 -2.02 0.00026 1.02 0.01247 miRNATAP -0.1 0 NA
114 hsa-miR-18a-5p GLRB -2.3 0 1.38 4.0E-5 MirTarget; miRNATAP -0.42 0 NA
115 hsa-miR-18a-5p GNA11 -2.3 0 0.19 0.66767 MirTarget -0.13 0 NA
116 hsa-miR-18a-5p GNG7 -2.3 0 -0.32 0.39849 mirMAP -0.1 0.00016 NA
117 hsa-miR-18a-5p GNPDA2 -2.3 0 0.44 0.24754 MirTarget -0.14 0 NA
118 hsa-miR-18a-5p GTF2A1 -2.3 0 0.31 0.27739 MirTarget -0.21 0 NA
119 hsa-miR-452-5p GUF1 -2.02 0.00026 0.44 0.35473 MirTarget -0.1 0 NA
120 hsa-miR-18a-5p H6PD -2.3 0 0.04 0.95545 mirMAP -0.13 0 NA
121 hsa-miR-18a-5p HERC1 -2.3 0 0.31 0.59955 miRNAWalker2 validate -0.17 0 NA
122 hsa-miR-18a-5p HIPK2 -2.3 0 0.04 0.95057 mirMAP -0.12 0 NA
123 hsa-miR-18a-5p HLF -2.3 0 -0.19 0.61478 MirTarget -0.23 0 NA
124 hsa-miR-18a-5p HMBOX1 -2.3 0 0.24 0.30584 MirTarget; miRNATAP -0.21 0 NA
125 hsa-miR-224-5p HOOK1 -2.66 0 0.32 0.49452 MirTarget -0.14 0 NA
126 hsa-miR-18a-5p HOXA9 -2.3 0 -0.3 0.24005 miRNAWalker2 validate -0.19 0 NA
127 hsa-miR-224-5p HS6ST3 -2.66 0 3.19 0 MirTarget -0.33 0 NA
128 hsa-miR-224-5p IGF1R -2.66 0 1.78 0.00817 mirMAP -0.26 0 NA
129 hsa-miR-452-5p IGF1R -2.02 0.00026 1.78 0.00817 mirMAP -0.34 0 NA
130 hsa-miR-18a-5p IGFBP5 -2.3 0 1.22 0.16438 mirMAP -0.23 0 NA
131 hsa-miR-18a-5p IL17B -2.3 0 -0.05 0.89446 MirTarget -0.28 0 NA
132 hsa-miR-452-5p IL6ST -2.02 0.00026 2.17 0.00017 mirMAP -0.22 0 NA
133 hsa-miR-452-5p INPP4B -2.02 0.00026 2.68 0 mirMAP -0.29 0 NA
134 hsa-miR-18a-5p ITGA2 -2.3 0 0.68 0.17493 MirTarget -0.28 0 NA
135 hsa-miR-224-5p ITPR1 -2.66 0 1.63 0.00386 MirTarget -0.11 0 NA
136 hsa-miR-18a-5p KCNA1 -2.3 0 0.29 0.40072 MirTarget; miRNATAP -0.37 0 NA
137 hsa-miR-224-5p KCNC1 -2.66 0 1.79 0 mirMAP -0.26 0 NA
138 hsa-miR-224-5p KCNE4 -2.66 0 2.62 0 mirMAP -0.3 0 NA
139 hsa-miR-224-5p KCNH1 -2.66 0 3.12 0 MirTarget -0.38 0 NA
140 hsa-miR-224-5p KIAA0040 -2.66 0 1.41 0.02535 mirMAP -0.16 0 NA
141 hsa-miR-452-5p KIAA1324L -2.02 0.00026 1.43 0.00021 MirTarget -0.11 1.0E-5 NA
142 hsa-miR-452-5p KIAA1958 -2.02 0.00026 0.42 0.02235 mirMAP -0.11 0 NA
143 hsa-miR-18a-5p KIF13B -2.3 0 1.26 0.0332 mirMAP -0.43 0 NA
144 hsa-miR-224-5p KIF26B -2.66 0 0.03 0.93576 mirMAP -0.14 0 NA
145 hsa-miR-452-5p KIF26B -2.02 0.00026 0.03 0.93576 mirMAP -0.22 0 NA
146 hsa-miR-452-5p KIF6 -2.02 0.00026 0.39 0.06419 mirMAP -0.13 0 NA
147 hsa-miR-224-5p KLHDC7A -2.66 0 4.35 0 mirMAP -0.4 0 NA
148 hsa-miR-452-5p KSR2 -2.02 0.00026 1.23 0 mirMAP -0.29 0 NA
149 hsa-miR-452-5p LARP4 -2.02 0.00026 0.51 0.34456 mirMAP -0.11 0 NA
150 hsa-miR-452-5p LCOR -2.02 0.00026 0.88 0.00031 mirMAP -0.15 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 19 153 5.294e-12 2.463e-08
2 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 20 204 1.147e-10 2.668e-07
3 BIOLOGICAL ADHESION 44 1032 2.93e-09 4.544e-06
4 CELL CELL ADHESION 31 608 1.455e-08 1.693e-05
5 MAMMARY GLAND DEVELOPMENT 11 117 2.848e-06 0.002209
6 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 15 218 2.497e-06 0.002209
7 RESPONSE TO STEROID HORMONE 23 497 5.777e-06 0.00352
8 REGULATION OF MUSCLE TISSUE DEVELOPMENT 10 103 6.053e-06 0.00352
9 HORMONE MEDIATED SIGNALING PATHWAY 12 158 9.389e-06 0.004854
10 ORGAN GROWTH 8 68 1.263e-05 0.005878
11 RESPONSE TO HORMONE 32 893 1.866e-05 0.007528
12 REGULATION OF CELLULAR COMPONENT MOVEMENT 29 771 1.941e-05 0.007528
13 GLAND DEVELOPMENT 19 395 2.235e-05 0.007998
NumGOOverlapSizeP ValueAdj. P Value
1 CALCIUM ION BINDING 31 697 3.09e-07 0.0002871
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PROJECTION 40 942 1.855e-08 1.083e-05
2 NEURON PART 46 1265 1.528e-07 4.461e-05
3 SYNAPSE 31 754 1.638e-06 0.0001692
4 PLASMA MEMBRANE REGION 36 929 9.133e-07 0.0001692
5 NEURON PROJECTION MEMBRANE 7 36 1.409e-06 0.0001692
6 CELL PROJECTION 55 1786 1.738e-06 0.0001692
7 MEMBRANE REGION 40 1134 2.297e-06 0.0001916
8 SYNAPTIC MEMBRANE 16 261 5.158e-06 0.0003765
9 SYNAPSE PART 26 610 6.218e-06 0.0004035
10 MAIN AXON 7 58 3.755e-05 0.002193
11 AXON 19 418 4.819e-05 0.002559
12 AXOLEMMA 4 14 5.672e-05 0.00276
13 DENDRITE 19 451 0.0001309 0.005882
14 AXON PART 12 219 0.0002244 0.009362

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04722_Neurotrophin_signaling_pathway 8 127 0.001016 0.1488
2 hsa04144_Endocytosis 10 203 0.001654 0.1488
3 hsa04970_Salivary_secretion 6 89 0.003059 0.1538
4 hsa04390_Hippo_signaling_pathway 8 154 0.003418 0.1538
5 hsa04115_p53_signaling_pathway 5 69 0.004952 0.1783
6 hsa04114_Oocyte_meiosis 6 114 0.0101 0.2819
7 hsa04310_Wnt_signaling_pathway 7 151 0.01096 0.2819
8 hsa04514_Cell_adhesion_molecules_.CAMs. 6 136 0.02231 0.4633
9 hsa04912_GnRH_signaling_pathway 5 101 0.02316 0.4633
10 hsa04010_MAPK_signaling_pathway 9 268 0.02912 0.5053
11 hsa04971_Gastric_acid_secretion 4 74 0.03088 0.5053
12 hsa04012_ErbB_signaling_pathway 4 87 0.05099 0.6892
13 hsa04710_Circadian_rhythm_._mammal 2 23 0.05177 0.6892
14 hsa04340_Hedgehog_signaling_pathway 3 56 0.06048 0.6892
15 hsa04530_Tight_junction 5 133 0.06277 0.6892
16 hsa00534_Glycosaminoglycan_biosynthesis_._heparan_sulfate 2 26 0.06448 0.6892
17 hsa04020_Calcium_signaling_pathway 6 177 0.06551 0.6892
18 hsa00030_Pentose_phosphate_pathway 2 27 0.06892 0.6892
19 hsa04120_Ubiquitin_mediated_proteolysis 5 139 0.07285 0.6902
20 hsa04720_Long.term_potentiation 3 70 0.1019 0.8357
21 hsa04730_Long.term_depression 3 70 0.1019 0.8357
22 hsa04510_Focal_adhesion 6 200 0.1027 0.8357
23 hsa04520_Adherens_junction 3 73 0.1119 0.8391
24 hsa04070_Phosphatidylinositol_signaling_system 3 78 0.1294 0.9315
25 hsa04350_TGF.beta_signaling_pathway 3 85 0.1554 1
26 hsa04512_ECM.receptor_interaction 3 85 0.1554 1
27 hsa04962_Vasopressin.regulated_water_reabsorption 2 44 0.1562 1
28 hsa04914_Progesterone.mediated_oocyte_maturation 3 87 0.1631 1
29 hsa04210_Apoptosis 3 89 0.1709 1
30 hsa04540_Gap_junction 3 90 0.1748 1
31 hsa04014_Ras_signaling_pathway 6 236 0.1784 1
32 hsa00510_N.Glycan_biosynthesis 2 49 0.1847 1
33 hsa04151_PI3K_AKT_signaling_pathway 8 351 0.202 1
34 hsa04972_Pancreatic_secretion 3 101 0.2197 1
35 hsa00562_Inositol_phosphate_metabolism 2 57 0.2316 1
36 hsa00010_Glycolysis_._Gluconeogenesis 2 65 0.2791 1
37 hsa04270_Vascular_smooth_muscle_contraction 3 116 0.284 1
38 hsa04976_Bile_secretion 2 71 0.3146 1
39 hsa04260_Cardiac_muscle_contraction 2 77 0.3497 1
40 hsa03015_mRNA_surveillance_pathway 2 83 0.3842 1
41 hsa04916_Melanogenesis 2 101 0.4823 1
42 hsa04670_Leukocyte_transendothelial_migration 2 117 0.561 1
43 hsa04110_Cell_cycle 2 128 0.6099 1
44 hsa04910_Insulin_signaling_pathway 2 138 0.6507 1
45 hsa04145_Phagosome 2 156 0.7156 1
46 hsa00230_Purine_metabolism 2 162 0.7348 1
47 hsa04062_Chemokine_signaling_pathway 2 189 0.8082 1
48 hsa04810_Regulation_of_actin_cytoskeleton 2 214 0.8595 1
49 hsa04740_Olfactory_transduction 2 388 0.9866 1

Quest ID: 10d009a2d28be1b5e38530e5ab4b430f