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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-29b-3p ABL1 0.02 0.91431 -0.21 0.07804 miRNATAP -0.24 0 NA
2 hsa-miR-29b-3p ABL2 0.02 0.91431 0.82 0 mirMAP -0.16 0 NA
3 hsa-miR-29b-3p ABLIM2 0.02 0.91431 0.29 0.2377 mirMAP -0.27 0.00018 NA
4 hsa-miR-29b-3p ACVR2A 0.02 0.91431 -0.41 0.00039 miRNATAP -0.11 0.00111 NA
5 hsa-miR-29b-3p ADAM11 0.02 0.91431 -0.37 0.13471 mirMAP -0.42 0 NA
6 hsa-miR-29b-3p ADAM19 0.02 0.91431 0.19 0.3039 MirTarget; miRNATAP -0.15 0.00528 NA
7 hsa-miR-29b-3p ADAM22 0.02 0.91431 0.64 0.00696 miRNATAP -0.32 0 NA
8 hsa-miR-29b-3p ADAMTS10 0.02 0.91431 0.32 0.12111 MirTarget; miRNATAP -0.32 0 NA
9 hsa-miR-29b-3p ADAMTS18 0.02 0.91431 3.26 0 miRNATAP -0.29 0.01017 NA
10 hsa-miR-29b-3p ADAMTS19 0.02 0.91431 -1.3 0.01069 miRNATAP -0.76 0 NA
11 hsa-miR-29b-3p ADAMTS6 0.02 0.91431 1.2 0 MirTarget; miRNATAP -0.3 0 NA
12 hsa-miR-29b-3p ADAMTS9 0.02 0.91431 0.8 3.0E-5 miRNATAP -0.29 0 NA
13 hsa-miR-29b-3p ADARB1 0.02 0.91431 -0.34 0.06631 mirMAP -0.36 0 NA
14 hsa-miR-29b-3p ADCY1 0.02 0.91431 0.36 0.16982 mirMAP -0.29 0.00014 NA
15 hsa-miR-29b-3p ADCYAP1R1 0.02 0.91431 -3.17 0 miRNATAP -0.9 0 NA
16 hsa-miR-29b-3p AFF4 0.02 0.91431 -0.27 0.01565 miRNATAP -0.15 0 NA
17 hsa-miR-29b-3p AGPAT4 0.02 0.91431 0.09 0.61321 MirTarget; miRNATAP -0.35 0 NA
18 hsa-miR-29b-3p AHNAK 0.02 0.91431 -1.21 0 MirTarget -0.3 0 NA
19 hsa-miR-29b-3p AKT3 0.02 0.91431 -0.27 0.18865 miRNATAP -0.51 0 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
20 hsa-miR-29b-3p ANK3 0.02 0.91431 -0.55 0.00086 miRNATAP -0.11 0.02889 NA
21 hsa-miR-29b-3p ANKRD13B 0.02 0.91431 1.41 0 MirTarget; miRNATAP -0.13 0.02422 NA
22 hsa-miR-29b-3p ANTXR2 0.02 0.91431 -0.73 0.00186 miRNATAP -0.35 0 NA
23 hsa-miR-29b-3p AP4E1 0.02 0.91431 0.05 0.63665 miRNATAP -0.1 0.00064 NA
24 hsa-miR-29b-3p APPBP2 0.02 0.91431 -0.15 0.05098 miRNATAP -0.14 0 NA
25 hsa-miR-29b-3p ARPP19 0.02 0.91431 0.11 0.27444 MirTarget; miRNATAP -0.13 0 NA
26 hsa-miR-29b-3p ARRDC3 0.02 0.91431 -0.15 0.28741 MirTarget; miRNATAP -0.25 0 NA
27 hsa-miR-29b-3p ARRDC4 0.02 0.91431 -1.01 0 miRNATAP -0.19 0.00021 NA
28 hsa-miR-29b-3p ARVCF 0.02 0.91431 0.32 0.05547 MirTarget; miRNATAP -0.27 0 NA
29 hsa-miR-29b-3p ASB1 0.02 0.91431 -0.28 0.00868 mirMAP -0.18 0 NA
30 hsa-miR-29b-3p ASIC1 0.02 0.91431 -0.41 0.13205 miRNATAP -0.29 0.00027 NA
31 hsa-miR-29b-3p ATP2B2 0.02 0.91431 -1.89 0 miRNATAP -0.8 0 NA
32 hsa-miR-29b-3p ATP2B4 0.02 0.91431 -0.64 0.00597 MirTarget; miRNATAP -0.54 0 NA
33 hsa-miR-29b-3p ATXN1 0.02 0.91431 -0.51 0.00026 miRNATAP -0.24 0 NA
34 hsa-miR-29b-3p ATXN1L 0.02 0.91431 -0.07 0.43241 miRNATAP -0.11 2.0E-5 NA
35 hsa-miR-29b-3p B4GALT6 0.02 0.91431 0.03 0.90707 MirTarget -0.2 0.00156 NA
36 hsa-miR-29b-3p BACE1 0.02 0.91431 -0.1 0.49755 miRNAWalker2 validate; miRTarBase; miRNATAP -0.39 0 NA
37 hsa-miR-29b-3p BACH2 0.02 0.91431 -0.15 0.55909 MirTarget; miRNATAP -0.25 0.00143 NA
38 hsa-miR-29b-3p BCL2 0.02 0.91431 -0.9 0 miRNAWalker2 validate; miRTarBase -0.2 0.00052 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29
39 hsa-miR-29b-3p BCORL1 0.02 0.91431 0.35 0.01214 miRNATAP -0.16 9.0E-5 NA
40 hsa-miR-29b-3p BLMH 0.02 0.91431 0.29 0.01725 MirTarget; miRNATAP -0.11 0.00183 NA
41 hsa-miR-29b-3p BRD3 0.02 0.91431 0.37 0.00013 miRNATAP -0.19 0 NA
42 hsa-miR-29b-3p BTBD7 0.02 0.91431 -0.17 0.03473 miRNATAP -0.1 1.0E-5 NA
43 hsa-miR-29b-3p BTG2 0.02 0.91431 -1.76 0 miRNATAP -0.17 0.00983 NA
44 hsa-miR-29b-3p C17orf51 0.02 0.91431 -0.24 0.16845 mirMAP -0.2 7.0E-5 NA
45 hsa-miR-29b-3p C1orf21 0.02 0.91431 -0.73 9.0E-5 miRNATAP -0.3 0 NA
46 hsa-miR-29b-3p C2CD4C 0.02 0.91431 0.08 0.77156 mirMAP -0.27 0.00063 NA
47 hsa-miR-29b-3p C5orf24 0.02 0.91431 0.08 0.41066 miRNATAP -0.18 0 NA
48 hsa-miR-29b-3p CACNA1C 0.02 0.91431 -0.18 0.557 MirTarget -0.7 0 NA
49 hsa-miR-29b-3p CACNG4 0.02 0.91431 -0.7 0.19815 miRNATAP -0.76 0 NA
50 hsa-miR-29b-3p CALU 0.02 0.91431 0.67 0 miRNAWalker2 validate; MirTarget -0.15 0 NA
51 hsa-miR-29b-3p CAMK1D 0.02 0.91431 -0.71 0.00255 miRNATAP -0.37 0 NA
52 hsa-miR-29b-3p CAMK2B 0.02 0.91431 -2.34 0 mirMAP -0.44 0.00028 NA
53 hsa-miR-29b-3p CAMK2G 0.02 0.91431 -0.53 0.00041 miRNATAP -0.27 0 NA
54 hsa-miR-29b-3p CAPN6 0.02 0.91431 -1.29 0.02537 miRNATAP -0.6 0.00041 NA
55 hsa-miR-29b-3p CAPN7 0.02 0.91431 -0.14 0.11991 miRNATAP -0.13 0 NA
56 hsa-miR-29b-3p CAV2 0.02 0.91431 -0.27 0.24247 MirTarget; miRNATAP -0.33 0 NA
57 hsa-miR-29b-3p CBFA2T2 0.02 0.91431 0.38 0.00165 mirMAP -0.19 0 NA
58 hsa-miR-29b-3p CBL 0.02 0.91431 0.29 0.01267 mirMAP -0.14 3.0E-5 NA
59 hsa-miR-29b-3p CBX1 0.02 0.91431 0.33 0.00082 miRNATAP -0.16 0 NA
60 hsa-miR-29b-3p CBX5 0.02 0.91431 0.16 0.24446 miRNATAP -0.17 4.0E-5 NA
61 hsa-miR-29b-3p CBX6 0.02 0.91431 -0.52 0.03506 miRNATAP -0.53 0 NA
62 hsa-miR-29b-3p CCND2 0.02 0.91431 -0.27 0.3112 MirTarget; miRNATAP -0.21 0.00653 24130168; 22330340 We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator
63 hsa-miR-29b-3p CD93 0.02 0.91431 0.56 0.00095 MirTarget -0.23 0 NA
64 hsa-miR-29b-3p CD99L2 0.02 0.91431 -0.29 0.07048 mirMAP -0.25 0 NA
65 hsa-miR-29b-3p CDC42BPA 0.02 0.91431 -0.05 0.73917 MirTarget; miRNATAP -0.18 7.0E-5 NA
66 hsa-miR-29b-3p CECR2 0.02 0.91431 -0.99 0.00379 miRNAWalker2 validate -0.43 2.0E-5 NA
67 hsa-miR-29b-3p CEP68 0.02 0.91431 -0.36 0.00246 MirTarget -0.24 0 NA
68 hsa-miR-29b-3p CFL2 0.02 0.91431 -1.3 0 miRNATAP -0.61 0 NA
69 hsa-miR-29b-3p CHD5 0.02 0.91431 -0.92 0.01521 mirMAP -0.87 0 NA
70 hsa-miR-29b-3p CHSY1 0.02 0.91431 0.46 1.0E-5 MirTarget; miRNATAP -0.13 1.0E-5 NA
71 hsa-miR-29b-3p CILP2 0.02 0.91431 3.02 0 MirTarget; miRNATAP -0.46 0.0003 NA
72 hsa-miR-29b-3p CLCN6 0.02 0.91431 -0.03 0.77926 mirMAP -0.18 0 NA
73 hsa-miR-29b-3p CLDN19 0.02 0.91431 -0.04 0.93631 mirMAP -0.37 0.00737 NA
74 hsa-miR-29b-3p CLEC2L 0.02 0.91431 0.44 0.37541 MirTarget; miRNATAP -0.74 0 NA
75 hsa-miR-29b-3p CNTN5 0.02 0.91431 -0.22 0.61957 miRNATAP -0.55 2.0E-5 NA
76 hsa-miR-29b-3p COL15A1 0.02 0.91431 0.68 0.00158 MirTarget; miRNATAP -0.27 2.0E-5 NA
77 hsa-miR-29b-3p COL16A1 0.02 0.91431 0.59 0.00556 miRNATAP -0.39 0 NA
78 hsa-miR-29b-3p COL1A2 0.02 0.91431 1.99 0 miRNATAP -0.26 0.00065 NA
79 hsa-miR-29b-3p COL3A1 0.02 0.91431 2.03 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.3 0.00014 NA
80 hsa-miR-29b-3p COL4A1 0.02 0.91431 1.79 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.32 0 NA
81 hsa-let-7g-5p COL4A2 0.3 0.02968 1.02 0 miRNATAP -0.49 0 NA
82 hsa-miR-1266-5p COL4A2 0.98 0.00203 1.02 0 MirTarget -0.21 0 NA
83 hsa-miR-155-5p COL4A2 0.71 0.00687 1.02 0 miRNAWalker2 validate -0.2 1.0E-5 NA
84 hsa-miR-16-5p COL4A2 0.47 0.02635 1.02 0 miRNAWalker2 validate -0.28 0 NA
85 hsa-miR-26b-5p COL4A2 -0.5 0.01181 1.02 0 miRNAWalker2 validate -0.31 0 NA
86 hsa-miR-29a-3p COL4A2 -0.24 0.13853 1.02 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.41 0 NA
87 hsa-miR-29b-3p COL4A2 0.02 0.91431 1.02 0 miRTarBase; MirTarget; miRNATAP -0.37 0 NA
88 hsa-miR-29c-3p COL4A2 -1.34 0 1.02 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.32 0 NA
89 hsa-miR-92a-3p COL4A2 1.06 0 1.02 0 miRNAWalker2 validate -0.24 7.0E-5 NA
90 hsa-miR-29b-3p COL4A3 0.02 0.91431 -0.75 0.03615 MirTarget; miRNATAP -0.34 0.00126 NA
91 hsa-miR-29b-3p COL4A4 0.02 0.91431 0.2 0.56272 MirTarget; miRNATAP -0.36 0.00048 NA
92 hsa-miR-29b-3p COL4A5 0.02 0.91431 -2.08 0 miRNATAP -0.64 0 NA
93 hsa-miR-29b-3p COL4A6 0.02 0.91431 -3.18 0 miRNATAP -0.73 0 NA
94 hsa-miR-29b-3p COL5A1 0.02 0.91431 1.68 0 MirTarget; miRNATAP -0.26 0.00033 NA
95 hsa-miR-29b-3p COL5A2 0.02 0.91431 1.97 0 MirTarget; miRNATAP -0.24 0.00035 NA
96 hsa-miR-29b-3p COL6A3 0.02 0.91431 1.53 0 MirTarget; miRNATAP -0.38 0 NA
97 hsa-miR-29b-3p CORO6 0.02 0.91431 -0.93 0.00193 miRNATAP -0.64 0 NA
98 hsa-miR-29b-3p CPEB3 0.02 0.91431 -0.73 0 MirTarget; miRNATAP -0.1 0.0033 NA
99 hsa-miR-29b-3p CPLX2 0.02 0.91431 -2.78 0 mirMAP -0.57 0.00099 NA
100 hsa-miR-29b-3p CPNE8 0.02 0.91431 0.01 0.9743 miRNATAP -0.33 0 NA
101 hsa-miR-29b-3p CREB5 0.02 0.91431 0.01 0.953 MirTarget; miRNATAP -0.39 0 NA
102 hsa-miR-29b-3p CRISPLD1 0.02 0.91431 1.34 1.0E-5 MirTarget; miRNATAP -0.75 0 NA
103 hsa-miR-29b-3p CSGALNACT2 0.02 0.91431 0.61 0 miRNATAP -0.24 0 NA
104 hsa-miR-29b-3p CSRNP2 0.02 0.91431 0.24 0.00293 miRNATAP -0.14 0 NA
105 hsa-miR-29b-3p CTDSPL2 0.02 0.91431 0.34 0.00044 MirTarget -0.13 0 NA
106 hsa-miR-29b-3p CYBRD1 0.02 0.91431 -1.57 0 MirTarget -0.38 0 NA
107 hsa-miR-29b-3p DAAM1 0.02 0.91431 -0.34 0.0105 MirTarget; miRNATAP -0.25 0 NA
108 hsa-miR-29b-3p DBT 0.02 0.91431 -0.4 0.0001 MirTarget -0.12 8.0E-5 NA
109 hsa-miR-29b-3p DCAF5 0.02 0.91431 -0.43 0 miRNATAP -0.11 0 NA
110 hsa-miR-29b-3p DCUN1D4 0.02 0.91431 -0.26 0.02159 MirTarget; miRNATAP -0.15 0 NA
111 hsa-miR-29b-3p DCX 0.02 0.91431 -0.84 0.10669 MirTarget; miRNATAP -0.85 0 NA
112 hsa-miR-29b-3p DDX3Y 0.02 0.91431 -1.08 0.26927 miRNATAP -0.71 0.01412 NA
113 hsa-miR-29b-3p DDX6 0.02 0.91431 0.09 0.36428 miRNATAP -0.15 0 NA
114 hsa-miR-29b-3p DGKH 0.02 0.91431 0.67 5.0E-5 miRNATAP -0.3 0 NA
115 hsa-miR-29b-3p DIO2 0.02 0.91431 1.13 1.0E-5 miRNATAP -0.41 0 NA
116 hsa-miR-29b-3p DIP2C 0.02 0.91431 -0.44 0.01713 MirTarget; miRNATAP -0.42 0 NA
117 hsa-miR-29b-3p DIRAS1 0.02 0.91431 -2.52 0 mirMAP -0.49 7.0E-5 NA
118 hsa-miR-29b-3p DLG2 0.02 0.91431 -1.81 0 MirTarget; miRNATAP -0.87 0 NA
119 hsa-miR-29b-3p DLGAP1 0.02 0.91431 -0.65 0.09462 miRNATAP -0.44 0.00011 NA
120 hsa-miR-29b-3p DNMT3A 0.02 0.91431 0.3 0.0262 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.2 0 25874772; 23939044; 26171207; 24798303; 26471361; 17890317; 22479643; 25746661 The de-regulation of the miR-29 family and DNA methyltransferase 3A DNMT3A is associated with gastric cancer GC;The miR-29 family miR-29a -29b and -29c which negatively regulates DNMT3A and DNMT3B was examined in association with the Wnt/β-catenin signaling pathway; The expression of miR-29a and miR-29b was partially regulated by DNMT3A and DNMT3B in a positive feedback loop;In addition a significant inverse correlation was identified between the expression levels of DNMT3A and miR-29b in estrogen receptor-positive breast cancer patients P=0.027;Consistent with miR-29's role in targeting DNA methyltransferase 3A DNMT3A a key enzyme regulating DNA methylation we found a significant inverse correlation P<0.001 between miR-29 and DNMT3A gene expression suggesting that they might be functionally antagonistic;Mechanistically ATDC exerted its oncogenic effects by suppressing miR-29 and subsequent upregulation of DNMT3A leading to DNA methylation and silencing of the tumor suppressor PTEN;Among the reported down-regulated miRNAs in lung cancer the miRNA miR-29 family 29a 29b and 29c has intriguing complementarities to the 3'-UTRs of DNA methyltransferase DNMT3A and -3B de novo methyltransferases two key enzymes involved in DNA methylation that are frequently up-regulated in lung cancer and associated with poor prognosis;The miR-29 family and predicted target genes were among the most strongly anti-correlated miRNA:mRNA pairs; over-expression of miR-29a in vitro repressed several anti-correlated genes including DNMT3A and DNMT3B and substantially decreased ovarian cancer cell viability;DNMT3A and 3B genes can be regulated post-transcriptionally by miR-29 family
121 hsa-miR-29b-3p DPYSL2 0.02 0.91431 0.6 0.0002 miRNATAP -0.25 0 NA
122 hsa-miR-29b-3p DPYSL3 0.02 0.91431 -0.04 0.90157 MirTarget -0.78 0 NA
123 hsa-miR-29b-3p DPYSL5 0.02 0.91431 0.21 0.71777 MirTarget; miRNATAP -1.26 0 NA
124 hsa-miR-29b-3p DRD1 0.02 0.91431 0.23 0.64754 miRNATAP -0.29 0.04991 NA
125 hsa-miR-29b-3p DRP2 0.02 0.91431 0.22 0.49257 miRNATAP -0.66 0 NA
126 hsa-miR-29b-3p ECE1 0.02 0.91431 0.12 0.25007 mirMAP -0.1 0.00112 NA
127 hsa-miR-29b-3p EHD2 0.02 0.91431 -0.36 0.08303 miRNATAP -0.37 0 NA
128 hsa-miR-29b-3p ELF2 0.02 0.91431 0.09 0.2369 MirTarget; miRNATAP -0.15 0 NA
129 hsa-miR-29b-3p ELL2 0.02 0.91431 -1.46 0 miRNATAP -0.13 0.01145 NA
130 hsa-miR-29b-3p ELMO2 0.02 0.91431 0.07 0.42477 miRNATAP -0.15 0 NA
131 hsa-miR-29b-3p ELN 0.02 0.91431 0.45 0.13752 MirTarget; miRNATAP -0.61 0 NA
132 hsa-miR-29b-3p ELOVL4 0.02 0.91431 -1.2 2.0E-5 miRNATAP -0.69 0 NA
133 hsa-miR-29b-3p ENTPD1 0.02 0.91431 0.24 0.0602 mirMAP -0.24 0 NA
134 hsa-miR-29b-3p EPHA3 0.02 0.91431 0.18 0.53588 miRNATAP -0.65 0 NA
135 hsa-miR-29b-3p EPHA8 0.02 0.91431 -0.71 0.12507 mirMAP -0.32 0.01905 NA
136 hsa-miR-29b-3p ERC1 0.02 0.91431 -0.11 0.38794 miRNATAP -0.19 0 NA
137 hsa-miR-29b-3p ESR1 0.02 0.91431 -1.04 3.0E-5 miRNAWalker2 validate; miRTarBase -0.19 0.0088 25622979 In the present study we show that S100A7 significantly upregulates the expression of miR-29b in Estrogen Receptor ER-positive breast cancer cells represented by MCF7 and significantly downregulates miR-29b in ER-negative cells represented by MDA-MB-231 Corrected
138 hsa-miR-29b-3p FAM168B 0.02 0.91431 -0.14 0.19372 MirTarget -0.23 0 NA
139 hsa-miR-29b-3p FBN1 0.02 0.91431 0.69 0.00279 miRNATAP -0.42 0 NA
140 hsa-miR-29b-3p FEM1B 0.02 0.91431 -0.19 0.08171 miRNATAP -0.26 0 NA
141 hsa-miR-29b-3p FERMT2 0.02 0.91431 -0.9 0.00065 MirTarget; miRNATAP -0.68 0 NA
142 hsa-miR-29b-3p FKRP 0.02 0.91431 -0.04 0.66297 mirMAP -0.13 0 NA
143 hsa-miR-29b-3p FOXK1 0.02 0.91431 0.73 0 mirMAP -0.16 0.00011 NA
144 hsa-miR-29b-3p FOXO3 0.02 0.91431 -0.04 0.72028 miRNATAP -0.15 0 NA
145 hsa-miR-29b-3p FOXO4 0.02 0.91431 -0.52 2.0E-5 miRNATAP -0.11 0.00308 NA
146 hsa-miR-29b-3p FRAS1 0.02 0.91431 0.69 0.06741 miRNATAP -0.43 9.0E-5 NA
147 hsa-miR-29b-3p FREM1 0.02 0.91431 -0.82 0.06787 MirTarget; miRNATAP -0.7 0 NA
148 hsa-miR-29b-3p FREM2 0.02 0.91431 -0.44 0.46353 MirTarget -0.7 6.0E-5 NA
149 hsa-miR-29b-3p FRMD4A 0.02 0.91431 -0.2 0.1546 miRNATAP -0.26 0 NA
150 hsa-miR-29b-3p FZD1 0.02 0.91431 0.08 0.61656 mirMAP -0.25 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NEUROGENESIS 77 1402 1.155e-13 5.376e-10
2 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 82 1672 6.517e-12 1.516e-08
3 EXTRACELLULAR STRUCTURE ORGANIZATION 29 304 4.98e-11 7.725e-08
4 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 14 79 1.98e-09 1.368e-06
5 MULTICELLULAR ORGANISM METABOLIC PROCESS 15 93 2.052e-09 1.368e-06
6 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 54 1008 2.059e-09 1.368e-06
7 CELL DEVELOPMENT 68 1426 1.82e-09 1.368e-06
8 CENTRAL NERVOUS SYSTEM DEVELOPMENT 49 872 2.637e-09 1.534e-06
9 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 44 750 5.054e-09 2.138e-06
10 REGULATION OF CELL DIFFERENTIATION 69 1492 4.802e-09 2.138e-06
11 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 78 1784 4.96e-09 2.138e-06
12 REGULATION OF CELL DEVELOPMENT 47 836 5.633e-09 2.184e-06
13 NEURON PROJECTION DEVELOPMENT 36 545 6.704e-09 2.4e-06
14 HEAD DEVELOPMENT 42 709 8.734e-09 2.64e-06
15 NEURON DIFFERENTIATION 48 874 8.055e-09 2.64e-06
16 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 57 1142 9.078e-09 2.64e-06
17 RESPONSE TO ENDOGENOUS STIMULUS 66 1450 2.026e-08 5.087e-06
18 CELLULAR COMPONENT MORPHOGENESIS 48 900 2.017e-08 5.087e-06
19 CARDIOVASCULAR SYSTEM DEVELOPMENT 44 788 2.186e-08 5.087e-06
20 CIRCULATORY SYSTEM DEVELOPMENT 44 788 2.186e-08 5.087e-06
21 NEURON DEVELOPMENT 40 687 3.228e-08 7.153e-06
22 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 33 513 5.482e-08 1.159e-05
23 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 63 1395 5.938e-08 1.201e-05
24 HEART DEVELOPMENT 31 466 6.63e-08 1.242e-05
25 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 27 368 6.674e-08 1.242e-05
26 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 43 801 9.685e-08 1.733e-05
27 POSITIVE REGULATION OF NEURON DIFFERENTIATION 24 306 1.056e-07 1.76e-05
28 REGULATION OF NEURON DIFFERENTIATION 34 554 1.059e-07 1.76e-05
29 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 49 983 1.15e-07 1.846e-05
30 REGULATION OF NEURON PROJECTION DEVELOPMENT 28 408 1.536e-07 2.383e-05
31 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 42 799 2.43e-07 3.647e-05
32 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 20 232 2.735e-07 3.978e-05
33 POSITIVE REGULATION OF CELL DEVELOPMENT 30 472 2.897e-07 4.085e-05
34 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 49 1021 3.566e-07 4.88e-05
35 NEURON PROJECTION MORPHOGENESIS 27 402 3.934e-07 5.085e-05
36 CELL PROJECTION ORGANIZATION 45 902 3.845e-07 5.085e-05
37 SKELETAL SYSTEM DEVELOPMENT 29 455 4.333e-07 5.305e-05
38 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 53 1152 4.266e-07 5.305e-05
39 MUSCLE STRUCTURE DEVELOPMENT 28 432 4.914e-07 5.716e-05
40 BIOLOGICAL ADHESION 49 1032 4.881e-07 5.716e-05
41 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 28 437 6.186e-07 7.02e-05
42 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 15 144 7.965e-07 8.824e-05
43 HEAD MORPHOGENESIS 8 36 9.879e-07 0.0001069
44 RESPONSE TO OXYGEN CONTAINING COMPOUND 59 1381 1.038e-06 0.0001098
45 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 22 303 1.323e-06 0.0001368
46 POSITIVE REGULATION OF CELL DIFFERENTIATION 41 823 1.353e-06 0.0001368
47 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 71 1805 1.552e-06 0.0001536
48 RESPONSE TO HORMONE 43 893 1.791e-06 0.0001703
49 DEVELOPMENTAL GROWTH 23 333 1.793e-06 0.0001703
50 ORGAN MORPHOGENESIS 41 841 2.324e-06 0.0002162
51 NEGATIVE REGULATION OF CELL DIFFERENTIATION 33 609 2.612e-06 0.0002383
52 REGULATION OF CELL PROJECTION ORGANIZATION 31 558 3.186e-06 0.0002851
53 ACTIN FILAMENT BASED PROCESS 27 450 3.41e-06 0.0002994
54 OVULATION CYCLE PROCESS 11 88 4.013e-06 0.0003458
55 SYNAPSE ORGANIZATION 14 145 4.567e-06 0.0003864
56 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 15 166 4.773e-06 0.0003966
57 BODY MORPHOGENESIS 8 44 4.951e-06 0.0004042
58 CYTOSKELETON ORGANIZATION 40 838 5.154e-06 0.0004134
59 POSITIVE REGULATION OF GENE EXPRESSION 67 1733 5.731e-06 0.0004519
60 GROWTH 25 410 5.949e-06 0.0004614
61 VASCULATURE DEVELOPMENT 27 469 7.294e-06 0.0005564
62 OVULATION CYCLE 12 113 8.245e-06 0.0006187
63 RESPONSE TO NITROGEN COMPOUND 40 859 9.238e-06 0.0006823
64 CELLULAR RESPONSE TO NITROGEN COMPOUND 28 505 9.949e-06 0.0007233
65 CELL GROWTH 13 135 1.027e-05 0.0007351
66 GLOMERULUS DEVELOPMENT 8 49 1.143e-05 0.0007938
67 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 8 49 1.143e-05 0.0007938
68 RHYTHMIC PROCESS 20 298 1.288e-05 0.000881
69 FACE DEVELOPMENT 8 50 1.335e-05 0.0008999
70 RESPONSE TO PEPTIDE 24 404 1.406e-05 0.0009326
71 INTRACELLULAR SIGNAL TRANSDUCTION 61 1572 1.423e-05 0.0009326
72 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 44 1004 1.478e-05 0.0009422
73 BEHAVIOR 28 516 1.476e-05 0.0009422
74 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 52 1275 1.752e-05 0.001101
75 COLLAGEN FIBRIL ORGANIZATION 7 38 1.79e-05 0.00111
76 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 11 104 2.034e-05 0.001245
77 CELLULAR RESPONSE TO AMINO ACID STIMULUS 8 53 2.078e-05 0.001256
78 RESPONSE TO OXYGEN LEVELS 20 311 2.386e-05 0.001423
79 ENSHEATHMENT OF NEURONS 10 91 3.46e-05 0.002012
80 AXON ENSHEATHMENT 10 91 3.46e-05 0.002012
81 TISSUE DEVELOPMENT 58 1518 3.679e-05 0.002113
82 CELL PART MORPHOGENESIS 31 633 3.785e-05 0.002147
83 CELLULAR RESPONSE TO ACID CHEMICAL 14 175 3.892e-05 0.002182
84 LOCOMOTION 46 1114 4.104e-05 0.002274
85 REGULATION OF METAL ION TRANSPORT 20 325 4.449e-05 0.002436
86 CELLULAR RESPONSE TO HORMONE STIMULUS 28 552 4.904e-05 0.002512
87 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 53 1360 4.913e-05 0.002512
88 SENSORY ORGAN DEVELOPMENT 26 493 4.803e-05 0.002512
89 MODULATION OF SYNAPTIC TRANSMISSION 19 301 4.887e-05 0.002512
90 REGULATION OF CELL PROLIFERATION 57 1496 4.669e-05 0.002512
91 REGULATION OF CELL MORPHOGENESIS 28 552 4.904e-05 0.002512
92 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 10 95 5.027e-05 0.002542
93 NEGATIVE REGULATION OF CELL DEVELOPMENT 19 303 5.343e-05 0.002617
94 MUSCLE ORGAN DEVELOPMENT 18 277 5.288e-05 0.002617
95 REGULATION OF NEURON DEATH 17 252 5.343e-05 0.002617
96 RESPONSE TO COCAINE 7 46 6.511e-05 0.003156
97 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 8 62 6.658e-05 0.003194
98 RESPONSE TO WOUNDING 28 563 6.897e-05 0.003275
99 POSITIVE REGULATION OF NUCLEAR TRANSCRIBED MRNA POLY A TAIL SHORTENING 4 11 7.048e-05 0.00328
100 REGULATION OF NUCLEAR TRANSCRIBED MRNA POLY A TAIL SHORTENING 4 11 7.048e-05 0.00328
101 REGULATION OF CALCIUM ION TRANSPORT 15 209 7.278e-05 0.003353
102 REGULATION OF MUSCLE ADAPTATION 8 63 7.48e-05 0.003412
103 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 32 689 7.772e-05 0.003511
104 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 66 1848 8.037e-05 0.003596
105 MUSCLE CELL DIFFERENTIATION 16 237 8.733e-05 0.00387
106 PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 34 9.299e-05 0.004082
107 RESPONSE TO ESTRADIOL 12 146 0.0001063 0.00462
108 DEVELOPMENTAL MATURATION 14 193 0.0001123 0.004839
109 CONNECTIVE TISSUE DEVELOPMENT 14 194 0.0001187 0.005065
110 NEGATIVE REGULATION OF CELL PROLIFERATION 30 643 0.0001199 0.005074
111 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 56 1517 0.0001268 0.005223
112 REGULATION OF CELLULAR COMPONENT MOVEMENT 34 771 0.0001267 0.005223
113 REGULATION OF TRANSPORT 64 1804 0.0001264 0.005223
114 SINGLE ORGANISM BEHAVIOR 21 384 0.0001545 0.006202
115 WOUND HEALING 24 470 0.0001524 0.006202
116 GLIOGENESIS 13 175 0.0001546 0.006202
117 PROTEIN PHOSPHORYLATION 39 944 0.0001596 0.006343
118 REGULATION OF ION TRANSPORT 28 592 0.0001608 0.006343
119 RESPONSE TO GROWTH FACTOR 24 475 0.0001785 0.006979
120 REGULATION OF HOMEOSTATIC PROCESS 23 447 0.0001865 0.007232
121 REGULATION OF SYSTEM PROCESS 25 507 0.0001913 0.007357
122 BONE DEVELOPMENT 12 156 0.0001988 0.007521
123 NEGATIVE REGULATION OF CELL COMMUNICATION 46 1192 0.0001988 0.007521
124 RESPONSE TO AMINO ACID 10 112 0.0002014 0.007557
125 REGULATION OF PHOSPHOLIPASE C ACTIVITY 6 39 0.0002054 0.007584
126 ASTROCYTE DIFFERENTIATION 6 39 0.0002054 0.007584
127 BLOOD VESSEL MORPHOGENESIS 20 364 0.0002072 0.007592
128 RESPONSE TO ABIOTIC STIMULUS 41 1024 0.0002098 0.007627
129 NEURON PROJECTION GUIDANCE 14 205 0.0002114 0.007627
130 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 19 337 0.0002144 0.007673
131 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 15 232 0.000231 0.008206
132 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 6 40 0.0002371 0.008233
133 NEGATIVE REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 6 40 0.0002371 0.008233
134 GLIAL CELL DIFFERENTIATION 11 136 0.0002353 0.008233
135 HINDBRAIN DEVELOPMENT 11 137 0.0002508 0.008646
136 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 13 184 0.0002537 0.008678
137 POSITIVE REGULATION OF NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS DEADENYLATION DEPENDENT DECAY 4 15 0.0002716 0.009093
138 FEMALE SEX DIFFERENTIATION 10 116 0.0002683 0.009093
139 REGULATION OF NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS DEADENYLATION DEPENDENT DECAY 4 15 0.0002716 0.009093
140 POSITIVE REGULATION OF TRANSPORT 38 936 0.0002737 0.009096
141 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 16 262 0.0002759 0.009106
142 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 32 740 0.0002826 0.009197
143 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 12 162 0.0002821 0.009197
144 REGULATION OF SYNAPTIC PLASTICITY 11 140 0.0003027 0.009782
145 RESPONSE TO ACID CHEMICAL 18 319 0.000309 0.009917
146 GLAND MORPHOGENESIS 9 97 0.0003124 0.009956
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR MATRIX STRUCTURAL CONSTITUENT 16 76 8.802e-12 8.177e-09
2 PLATELET DERIVED GROWTH FACTOR BINDING 7 11 7.872e-10 3.656e-07
3 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 53 1199 1.433e-06 0.0004439
4 GROWTH FACTOR BINDING 13 123 3.669e-06 0.0008521
5 CYTOSKELETAL PROTEIN BINDING 39 819 7.18e-06 0.0009188
6 ACTIN BINDING 24 393 8.901e-06 0.0009188
7 METALLOENDOPEPTIDASE ACTIVITY 12 113 8.245e-06 0.0009188
8 ZINC ION BINDING 50 1155 5.22e-06 0.0009188
9 MACROMOLECULAR COMPLEX BINDING 57 1399 6.843e-06 0.0009188
10 PROTEIN COMPLEX BINDING 42 935 1.305e-05 0.001212
11 ENZYME BINDING 65 1737 2.258e-05 0.001907
12 TRANSITION METAL ION BINDING 55 1400 2.806e-05 0.002172
13 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 31 629 3.359e-05 0.0024
14 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 29 588 5.944e-05 0.003944
15 CELL ADHESION MOLECULE BINDING 14 186 7.565e-05 0.004685
16 INTEGRIN BINDING 10 105 0.0001178 0.006439
17 RECEPTOR BINDING 55 1476 0.000115 0.006439
18 CALMODULIN BINDING 13 179 0.0001935 0.009987
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR MATRIX COMPONENT 27 125 2.697e-19 1.575e-16
2 EXTRACELLULAR MATRIX 45 426 3.542e-18 1.034e-15
3 PROTEINACEOUS EXTRACELLULAR MATRIX 41 356 5.384e-18 1.048e-15
4 BASEMENT MEMBRANE 19 93 1.717e-13 2.508e-11
5 COMPLEX OF COLLAGEN TRIMERS 11 23 6.223e-13 7.269e-11
6 NEURON PART 62 1265 3.735e-09 3.636e-07
7 SOMATODENDRITIC COMPARTMENT 40 650 7.012e-09 5.85e-07
8 COLLAGEN TRIMER 14 88 8.531e-09 6.227e-07
9 NEURON PROJECTION 50 942 1.163e-08 7.544e-07
10 ENDOPLASMIC RETICULUM LUMEN 19 201 1.295e-07 7.563e-06
11 CELL JUNCTION 54 1151 1.766e-07 9.376e-06
12 SYNAPSE 40 754 3.774e-07 1.837e-05
13 DENDRITE 27 451 3.554e-06 0.0001596
14 T TUBULE 8 45 5.905e-06 0.0002463
15 CELL BODY 28 494 6.611e-06 0.0002574
16 AXON 24 418 2.45e-05 0.0008944
17 CELL PROJECTION 66 1786 2.862e-05 0.0009833
18 SYNAPSE PART 30 610 4.674e-05 0.001517
19 BANDED COLLAGEN FIBRIL 4 12 0.0001039 0.003193
20 SARCOLEMMA 11 125 0.0001114 0.003254
21 ACTIN CYTOSKELETON 23 444 0.0001692 0.004705
22 FIBRIL 4 14 0.0002027 0.005382
23 PLATELET ALPHA GRANULE 8 75 0.0002583 0.00656
24 POSTSYNAPSE 20 378 0.0003384 0.008234
25 HISTONE DEACETYLASE COMPLEX 7 61 0.0003985 0.00931
26 ACTOMYOSIN 7 62 0.0004408 0.009901

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 23 199 1.163e-10 6.046e-09
2 Ras_signaling_pathway_hsa04014 20 232 2.735e-07 6.58e-06
3 PI3K_Akt_signaling_pathway_hsa04151 25 352 3.796e-07 6.58e-06
4 ECM_receptor_interaction_hsa04512 11 82 1.979e-06 2.572e-05
5 FoxO_signaling_pathway_hsa04068 13 132 8.031e-06 8.352e-05
6 ErbB_signaling_pathway_hsa04012 9 85 0.0001138 0.0009859
7 cAMP_signaling_pathway_hsa04024 14 198 0.0001472 0.001093
8 AMPK_signaling_pathway_hsa04152 10 121 0.0003773 0.002452
9 Calcium_signaling_pathway_hsa04020 12 182 0.0008035 0.004642
10 Cellular_senescence_hsa04218 11 160 0.000933 0.004723
11 Apelin_signaling_pathway_hsa04371 10 137 0.0009991 0.004723
12 Phospholipase_D_signaling_pathway_hsa04072 10 146 0.001617 0.006468
13 Wnt_signaling_pathway_hsa04310 10 146 0.001617 0.006468
14 Regulation_of_actin_cytoskeleton_hsa04810 12 208 0.0025 0.009287
15 Gap_junction_hsa04540 7 88 0.003476 0.01205
16 Rap1_signaling_pathway_hsa04015 11 206 0.006604 0.02139
17 HIF_1_signaling_pathway_hsa04066 7 100 0.006994 0.02139
18 Hippo_signaling_pathway_hsa04390 9 154 0.007672 0.02216
19 Jak_STAT_signaling_pathway_hsa04630 9 162 0.01051 0.02875
20 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 8 139 0.01267 0.03294
21 MAPK_signaling_pathway_hsa04010 13 295 0.01535 0.038
22 Oocyte_meiosis_hsa04114 7 124 0.02101 0.04965
23 Autophagy_animal_hsa04140 7 128 0.02449 0.05537
24 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.02605 0.05644
25 cGMP_PKG_signaling_pathway_hsa04022 8 163 0.02972 0.06181
26 Cell_cycle_hsa04110 6 124 0.05888 0.1178
27 TGF_beta_signaling_pathway_hsa04350 4 84 0.1175 0.2253
28 mTOR_signaling_pathway_hsa04150 6 151 0.1213 0.2253
29 Cytokine_cytokine_receptor_interaction_hsa04060 9 270 0.1498 0.2686
30 Apoptosis_multiple_species_hsa04215 2 33 0.1666 0.2888
31 Mitophagy_animal_hsa04137 3 65 0.176 0.291
32 Tight_junction_hsa04530 6 170 0.1791 0.291
33 Adherens_junction_hsa04520 3 72 0.2158 0.3367
34 TNF_signaling_pathway_hsa04668 4 108 0.2201 0.3367
35 Phagosome_hsa04145 5 152 0.2507 0.3725
36 Sphingolipid_signaling_pathway_hsa04071 4 118 0.2684 0.3876
37 Hedgehog_signaling_pathway_hsa04340 2 47 0.2813 0.3953
38 Apoptosis_hsa04210 4 138 0.3688 0.4928
39 Phosphatidylinositol_signaling_system_hsa04070 3 99 0.3787 0.4928
40 VEGF_signaling_pathway_hsa04370 2 59 0.3791 0.4928
41 Cell_adhesion_molecules_.CAMs._hsa04514 4 145 0.404 0.5124
42 p53_signaling_pathway_hsa04115 2 68 0.4487 0.5556
43 Endocytosis_hsa04144 6 244 0.4601 0.5564
44 Necroptosis_hsa04217 4 164 0.4972 0.5876
45 Neuroactive_ligand_receptor_interaction_hsa04080 6 278 0.587 0.6783
46 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.6278 0.7097

Quest ID: 10d010fd4b9f593c60b6aa4326152952