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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-592 ADSSL1 0.03 0.97121 -0.16 0.65494 miRNATAP -0.22 0 NA
2 hsa-miR-592 AGPAT4 0.03 0.97121 0.17 0.74406 mirMAP -0.25 0 NA
3 hsa-miR-592 ANTXR1 0.03 0.97121 0.14 0.90557 mirMAP -0.16 0.00076 NA
4 hsa-miR-592 ARHGEF4 0.03 0.97121 0.25 0.56835 miRNATAP -0.36 0 NA
5 hsa-miR-592 ATP8B2 0.03 0.97121 0 0.9954 PITA; miRNATAP -0.2 0 NA
6 hsa-miR-592 BARX1 0.03 0.97121 0.24 0.77459 PITA -0.14 0.0322 NA
7 hsa-miR-592 BEND4 0.03 0.97121 -0.11 0.88946 MirTarget; miRNATAP -0.13 0.02003 NA
8 hsa-miR-592 BHLHE41 0.03 0.97121 0.52 0.4886 miRNATAP -0.17 1.0E-5 NA
9 hsa-miR-592 BNC2 0.03 0.97121 0.15 0.76233 miRNATAP -0.22 0 NA
10 hsa-miR-592 CACNA1E 0.03 0.97121 -0.51 0.36647 mirMAP -0.21 0.00054 NA
11 hsa-miR-592 CARTPT 0.03 0.97121 0.45 0.6399 MirTarget; miRNATAP -0.21 0.0086 NA
12 hsa-miR-592 CDK14 0.03 0.97121 0.17 0.74369 MirTarget -0.23 0 NA
13 hsa-miR-592 COL8A1 0.03 0.97121 -0.06 0.93052 miRNATAP -0.25 1.0E-5 NA
14 hsa-miR-592 COL8A2 0.03 0.97121 -0.15 0.80917 MirTarget; PITA; miRNATAP -0.16 0.00058 NA
15 hsa-miR-592 CORO2B 0.03 0.97121 0.6 0.10777 MirTarget -0.14 0.00239 NA
16 hsa-miR-592 CRISPLD1 0.03 0.97121 -0.01 0.97289 MirTarget -0.12 0.01925 NA
17 hsa-miR-592 CSGALNACT2 0.03 0.97121 0.04 0.95721 MirTarget -0.11 0 NA
18 hsa-miR-592 CYP1B1 0.03 0.97121 0.06 0.92234 MirTarget; miRNATAP -0.4 0 NA
19 hsa-miR-592 DAAM2 0.03 0.97121 0.02 0.96771 mirMAP -0.12 0.00127 NA
20 hsa-miR-592 DCLK1 0.03 0.97121 0.01 0.98653 MirTarget -0.23 4.0E-5 NA
21 hsa-miR-592 DLG2 0.03 0.97121 0.05 0.9264 MirTarget; miRNATAP -0.15 0.00719 NA
22 hsa-miR-592 EFNA5 0.03 0.97121 0.11 0.83329 mirMAP; miRNATAP -0.24 5.0E-5 NA
23 hsa-miR-592 EIF4E3 0.03 0.97121 0.08 0.92283 PITA; miRNATAP -0.14 0 NA
24 hsa-miR-592 EPHA4 0.03 0.97121 -0.07 0.90219 mirMAP -0.3 0 NA
25 hsa-miR-592 ESAM 0.03 0.97121 0.29 0.70501 miRNATAP -0.12 0 NA
26 hsa-miR-592 FAM26E 0.03 0.97121 -0.05 0.90614 mirMAP -0.17 2.0E-5 NA
27 hsa-miR-592 FAM46A 0.03 0.97121 -0.47 0.58831 PITA -0.14 0 NA
28 hsa-miR-592 FIGN 0.03 0.97121 0.07 0.90169 mirMAP -0.11 0.02756 NA
29 hsa-miR-592 FLNC 0.03 0.97121 -0.01 0.99023 mirMAP -0.38 0 NA
30 hsa-miR-592 FRAS1 0.03 0.97121 0.39 0.51896 mirMAP -0.19 0.00258 NA
31 hsa-miR-592 FUT8 0.03 0.97121 -0.38 0.69893 PITA; miRNATAP -0.16 0 NA
32 hsa-miR-592 GM2A 0.03 0.97121 -0.09 0.93677 MirTarget -0.11 0 NA
33 hsa-miR-592 GRAMD1B 0.03 0.97121 0 0.99784 mirMAP -0.36 0 NA
34 hsa-miR-592 GRIN2A 0.03 0.97121 -0.17 0.83854 PITA -0.15 0.00933 NA
35 hsa-miR-592 HOMER2 0.03 0.97121 -0.06 0.91605 mirMAP -0.33 0 NA
36 hsa-miR-592 HOXC9 0.03 0.97121 0.61 0.35343 PITA; miRNATAP -0.47 0 NA
37 hsa-miR-592 IGF1 0.03 0.97121 -0.24 0.64209 mirMAP -0.18 0.00559 NA
38 hsa-miR-592 IGF2BP3 0.03 0.97121 0.06 0.92407 PITA -0.38 0 NA
39 hsa-miR-592 IGFBP5 0.03 0.97121 0.29 0.83829 mirMAP -0.17 7.0E-5 NA
40 hsa-miR-592 IL6ST 0.03 0.97121 0.01 0.98821 PITA -0.15 0 NA
41 hsa-miR-592 KCND2 0.03 0.97121 0.47 0.42141 MirTarget; PITA -0.4 0 NA
42 hsa-miR-592 KCND3 0.03 0.97121 -0.31 0.56677 mirMAP -0.38 0 NA
43 hsa-miR-592 KCNJ5 0.03 0.97121 0.2 0.70085 mirMAP -0.3 0 NA
44 hsa-miR-592 KIAA1644 0.03 0.97121 0.04 0.92607 mirMAP -0.25 0 NA
45 hsa-miR-592 LMO3 0.03 0.97121 0.19 0.74128 MirTarget; PITA; miRNATAP -0.16 0.03562 NA
46 hsa-miR-592 LRRC4C 0.03 0.97121 0.3 0.65289 MirTarget; PITA; miRNATAP -0.26 3.0E-5 NA
47 hsa-miR-592 MAF 0.03 0.97121 -0.01 0.98665 PITA; miRNATAP -0.11 0.00022 NA
48 hsa-miR-592 MAP3K6 0.03 0.97121 -0.26 0.74311 miRNATAP -0.22 0 NA
49 hsa-miR-592 MAP9 0.03 0.97121 -0.01 0.9723 MirTarget -0.1 0.03479 NA
50 hsa-miR-592 MBOAT2 0.03 0.97121 0.01 0.98858 mirMAP -0.15 0 NA
51 hsa-miR-592 MCC 0.03 0.97121 0.35 0.45664 mirMAP -0.13 0.00011 NA
52 hsa-miR-592 MDFIC 0.03 0.97121 0.26 0.69711 MirTarget -0.15 2.0E-5 NA
53 hsa-miR-592 MEGF10 0.03 0.97121 0.4 0.5126 mirMAP -0.19 0.00012 NA
54 hsa-miR-592 MMP16 0.03 0.97121 0.34 0.32953 mirMAP -0.12 0.00175 NA
55 hsa-miR-592 MPPED2 0.03 0.97121 0.23 0.6538 miRNATAP -0.12 0.00565 NA
56 hsa-miR-592 MXRA7 0.03 0.97121 -0.01 0.99417 MirTarget -0.12 2.0E-5 NA
57 hsa-miR-592 MYO5A 0.03 0.97121 -0.07 0.90315 mirMAP -0.19 0 NA
58 hsa-miR-592 NFIC 0.03 0.97121 -0.19 0.80725 mirMAP -0.14 0 NA
59 hsa-miR-592 NOVA1 0.03 0.97121 0.17 0.7775 PITA; miRNATAP -0.13 0.02776 NA
60 hsa-miR-592 NPR3 0.03 0.97121 0.1 0.88078 miRNATAP -0.22 0.00131 NA
61 hsa-miR-592 NPTX1 0.03 0.97121 0.3 0.63972 PITA -0.16 0.0227 NA
62 hsa-miR-592 NRK 0.03 0.97121 0.29 0.61745 PITA; miRNATAP -0.19 0.00353 NA
63 hsa-miR-592 NRP2 0.03 0.97121 0.2 0.8114 PITA; miRNATAP -0.18 0 NA
64 hsa-miR-592 NRXN1 0.03 0.97121 0.52 0.54683 mirMAP -0.34 0 NA
65 hsa-miR-592 OSM 0.03 0.97121 -0.04 0.9368 PITA; miRNATAP -0.24 0 NA
66 hsa-miR-592 PACSIN3 0.03 0.97121 -0.16 0.83198 MirTarget -0.1 0.00888 NA
67 hsa-miR-592 PAX5 0.03 0.97121 -0.54 0.44768 mirMAP -0.23 0.00348 NA
68 hsa-miR-592 PCDH17 0.03 0.97121 0.18 0.72189 PITA -0.13 2.0E-5 NA
69 hsa-miR-592 PCDH7 0.03 0.97121 0.25 0.67465 PITA -0.2 1.0E-5 NA
70 hsa-miR-592 PCDH9 0.03 0.97121 0.5 0.39684 PITA -0.19 0.00019 NA
71 hsa-miR-592 PDE4D 0.03 0.97121 0.16 0.82668 PITA; miRNATAP -0.18 0 NA
72 hsa-miR-592 PEG10 0.03 0.97121 0.19 0.72811 mirMAP -0.27 0.00017 NA
73 hsa-miR-592 PLCXD3 0.03 0.97121 0.09 0.91708 PITA; miRNATAP -0.33 0 NA
74 hsa-miR-592 PLXDC2 0.03 0.97121 -0.03 0.966 MirTarget -0.25 0 NA
75 hsa-miR-592 PLXNA4 0.03 0.97121 -0.23 0.63131 mirMAP -0.21 0.00018 NA
76 hsa-miR-592 PODN 0.03 0.97121 0.01 0.99329 miRNATAP -0.1 0.03077 NA
77 hsa-miR-592 PTHLH 0.03 0.97121 0.22 0.51364 PITA -0.21 0 NA
78 hsa-miR-592 PTRF 0.03 0.97121 -0.04 0.97513 miRNATAP -0.21 0 NA
79 hsa-miR-592 QKI 0.03 0.97121 0.17 0.83965 PITA; mirMAP -0.13 1.0E-5 NA
80 hsa-miR-592 RAB3B 0.03 0.97121 -0.7 0.18063 mirMAP; miRNATAP -0.31 0 NA
81 hsa-miR-592 RIMKLB 0.03 0.97121 0.48 0.19601 MirTarget -0.13 0.00042 NA
82 hsa-miR-592 RPS6KA2 0.03 0.97121 -0.09 0.91552 mirMAP -0.14 0 NA
83 hsa-miR-592 SCD5 0.03 0.97121 -0.05 0.93114 MirTarget -0.15 0.00012 NA
84 hsa-miR-592 SCN9A 0.03 0.97121 -0.05 0.9032 PITA -0.24 1.0E-5 NA
85 hsa-miR-592 SHE 0.03 0.97121 0.03 0.93675 PITA; miRNATAP -0.16 0 NA
86 hsa-miR-592 SLC7A2 0.03 0.97121 -0.17 0.72477 mirMAP -0.42 0 NA
87 hsa-miR-592 SNAP25 0.03 0.97121 0.14 0.83005 PITA -0.27 1.0E-5 NA
88 hsa-miR-592 SNCA 0.03 0.97121 0.01 0.98153 miRNATAP -0.31 0 NA
89 hsa-miR-592 SPARC 0.03 0.97121 0.17 0.92037 MirTarget -0.18 0 NA
90 hsa-miR-592 SUSD4 0.03 0.97121 0 0.99994 PITA -0.18 0.00014 NA
91 hsa-miR-592 SYNGR1 0.03 0.97121 -0.02 0.96 mirMAP -0.23 0 NA
92 hsa-miR-592 TANC2 0.03 0.97121 -0.08 0.9093 miRNATAP -0.24 0 NA
93 hsa-miR-592 TCEAL6 0.03 0.97121 -0.08 0.82698 PITA -0.16 0 NA
94 hsa-miR-592 TFAP2A 0.03 0.97121 -0.73 0.21005 MirTarget; PITA -0.48 0 NA
95 hsa-miR-592 THSD7A 0.03 0.97121 0.08 0.84627 PITA -0.28 0 NA
96 hsa-miR-592 TIAM1 0.03 0.97121 0.14 0.74558 PITA -0.22 0 NA
97 hsa-miR-592 TRIM7 0.03 0.97121 -0.51 0.39758 miRNATAP -0.56 0 NA
98 hsa-miR-592 TUSC5 0.03 0.97121 -0.44 0.66449 mirMAP -0.25 0.00227 NA
99 hsa-miR-592 ZNF618 0.03 0.97121 -0.03 0.96952 mirMAP -0.2 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 SINGLE ORGANISM BEHAVIOR 13 384 5.481e-08 0.0001275
2 BEHAVIOR 15 516 3.588e-08 0.0001275
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 CATION CHANNEL COMPLEX 8 167 1.794e-06 0.001048
2 TRANSPORTER COMPLEX 10 321 4.347e-06 0.001269
3 SITE OF POLARIZED GROWTH 7 149 9.286e-06 0.001419
4 SYNAPSE PART 13 610 9.722e-06 0.001419
5 PLATELET ALPHA GRANULE MEMBRANE 3 13 3.246e-05 0.003682
6 PLASMA MEMBRANE REGION 15 929 5.043e-05 0.003682
7 PLASMA MEMBRANE PROTEIN COMPLEX 11 510 4.436e-05 0.003682
8 SYNAPTIC MEMBRANE 8 261 4.645e-05 0.003682
9 CELL PROJECTION PART 15 946 6.192e-05 0.004018
10 POTASSIUM CHANNEL COMPLEX 5 90 8.456e-05 0.004635
11 SYNAPSE 13 754 8.731e-05 0.004635
12 POSTSYNAPSE 9 378 0.0001084 0.005274
13 AXONAL GROWTH CONE 3 20 0.0001262 0.005668
14 NEURON PART 17 1265 0.0001471 0.006136
15 NEURON PROJECTION 14 942 0.0002186 0.008511

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 6 295 0.003486 0.1813
2 Rap1_signaling_pathway_hsa04015 4 206 0.01926 0.4596
3 Ras_signaling_pathway_hsa04014 4 232 0.02824 0.4596
4 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.03535 0.4596
5 cAMP_signaling_pathway_hsa04024 3 198 0.0753 0.7831
6 AMPK_signaling_pathway_hsa04152 2 121 0.1208 0.8725
7 Oocyte_meiosis_hsa04114 2 124 0.1257 0.8725
8 FoxO_signaling_pathway_hsa04068 2 132 0.1391 0.8725
9 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.151 0.8725
10 mTOR_signaling_pathway_hsa04150 2 151 0.1719 0.8773
11 Jak_STAT_signaling_pathway_hsa04630 2 162 0.1914 0.8773
12 Tight_junction_hsa04530 2 170 0.2058 0.8773
13 Calcium_signaling_pathway_hsa04020 2 182 0.2276 0.8773
14 PI3K_Akt_signaling_pathway_hsa04151 3 352 0.2532 0.8773
15 Focal_adhesion_hsa04510 2 199 0.2587 0.8773
16 Regulation_of_actin_cytoskeleton_hsa04810 2 208 0.2752 0.8773
17 Cytokine_cytokine_receptor_interaction_hsa04060 2 270 0.3871 1

Quest ID: 10da13107f9dc2388312387e22d1061c