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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-126-5p ZHX1 0.45 0.0113 -0.33 0.00109 mirMAP -0.12 0.00037 NA
2 hsa-miR-140-5p ZHX1 0.13 0.45796 -0.33 0.00109 miRNATAP -0.16 1.0E-5 NA
3 hsa-miR-16-5p ZHX1 0.47 0.02635 -0.33 0.00109 miRNATAP -0.13 1.0E-5 NA
4 hsa-miR-186-5p ZHX1 0.36 0.01969 -0.33 0.00109 mirMAP; miRNATAP -0.17 4.0E-5 NA
5 hsa-miR-199a-3p ZHX1 1.04 0 -0.33 0.00109 PITA; miRNATAP -0.11 0.00267 25448600 MiR 199a 3p promotes gastric cancer progression by targeting ZHX1; In addition the expression of miR-199a-3p was inversely associated with that of ZHX1 in GC cell lines; Overexpression of miR-199a-3p in SGC-7901 cells inhibited ZHX1 expression while reduction in miR-199a-3p by inhibitors in NCI-N87 cells enhanced ZHX1 expression; Moreover restoring ZHX1 expression in SGC-7901/miR-199a-3p cells inhibited the cell proliferation induced by miR-199a-3p; Taken together these findings suggest that miR-199a-3p may function as a novel tumor promoter in GC and its oncogenic activity may involve the direct targeting and inhibition of ZHX1
6 hsa-miR-199b-3p ZHX1 1.05 0 -0.33 0.00109 PITA; miRNATAP -0.11 0.00261 NA
7 hsa-miR-212-3p ZHX1 0.81 0 -0.33 0.00109 miRNATAP -0.12 0.00059 NA
8 hsa-miR-27a-3p ZHX1 0.52 0.00012 -0.33 0.00109 miRNATAP -0.14 0.00283 NA
9 hsa-miR-30e-3p ZHX1 -0.44 0.0005 -0.33 0.00109 mirMAP -0.15 0.00182 NA
10 hsa-miR-32-5p ZHX1 0.43 0.04021 -0.33 0.00109 miRNAWalker2 validate -0.12 4.0E-5 NA
11 hsa-miR-424-5p ZHX1 0.96 0.00035 -0.33 0.00109 miRNATAP -0.13 0 NA
12 hsa-miR-454-3p ZHX1 0.82 1.0E-5 -0.33 0.00109 miRNATAP -0.11 0.00049 NA
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 BCYRN1 hsa-miR-126-5p;hsa-miR-140-5p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-212-3p;hsa-miR-27a-3p;hsa-miR-30e-3p;hsa-miR-32-5p;hsa-miR-424-5p;hsa-miR-454-3p 10 ZHX1 Sponge network 0.311 0.10344 -0.327 0.00109 0.283
2 LINC00641 hsa-miR-126-5p;hsa-miR-140-5p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-212-3p;hsa-miR-27a-3p;hsa-miR-30e-3p;hsa-miR-424-5p 10 ZHX1 Sponge network -0.222 0.32445 -0.327 0.00109 0.277

Quest ID: 1194879d0774d98ac68f14de9ea8c351