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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-28-5p AAAS -0.14 0.04976 0.33 0 miRNAWalker2 validate -0.19 0 NA
2 hsa-miR-28-5p AAGAB -0.14 0.04976 0.81 0 miRanda -0.26 0 NA
3 hsa-miR-28-5p AATK -0.14 0.04976 0.45 0.00408 miRanda -0.27 0.00027 NA
4 hsa-miR-28-5p ABCB9 -0.14 0.04976 0.95 0 miRanda -0.26 0 NA
5 hsa-miR-28-5p ABCC5 -0.14 0.04976 0.8 0 miRanda -0.16 0.00553 NA
6 hsa-miR-28-5p ABHD1 -0.14 0.04976 -0.98 0 miRanda -0.3 7.0E-5 NA
7 hsa-miR-28-5p ABLIM3 -0.14 0.04976 -1.88 0 miRanda -0.64 0 NA
8 hsa-miR-28-5p ACACA -0.14 0.04976 -0.22 0.02162 miRanda -0.16 0.00043 NA
9 hsa-miR-28-5p ACAD8 -0.14 0.04976 -0.36 0 miRanda -0.12 0.00017 NA
10 hsa-miR-28-5p ACAT1 -0.14 0.04976 -0.75 0 miRanda -0.16 0.00027 NA
11 hsa-miR-28-5p ACOX3 -0.14 0.04976 0.2 0.02327 miRanda -0.18 1.0E-5 NA
12 hsa-miR-28-5p ACSF2 -0.14 0.04976 -0.26 0.05489 miRanda -0.31 0 NA
13 hsa-miR-28-5p ADAMTS13 -0.14 0.04976 0.49 0.00058 miRanda -0.25 0.0002 NA
14 hsa-miR-28-5p ADCK1 -0.14 0.04976 0.19 0.00451 miRanda -0.12 0.00012 NA
15 hsa-miR-28-5p ADCY1 -0.14 0.04976 -0.05 0.84149 miRanda -0.59 0 NA
16 hsa-miR-28-5p ADCY6 -0.14 0.04976 -0.63 0 miRanda -0.32 0 NA
17 hsa-miR-28-5p AFF1 -0.14 0.04976 -0.82 0 miRanda -0.18 2.0E-5 NA
18 hsa-miR-28-5p AFF4 -0.14 0.04976 -0.28 0.00153 miRanda -0.2 0 NA
19 hsa-miR-28-5p AFTPH -0.14 0.04976 0.31 0 miRanda -0.1 0.00074 NA
20 hsa-miR-28-5p AGAP11 -0.14 0.04976 -2.72 0 miRanda -0.31 0.00022 NA
21 hsa-miR-28-5p AGBL4 -0.14 0.04976 -0.14 0.45129 miRanda -0.24 0.00912 NA
22 hsa-let-7e-5p AGMAT 0.26 0.00191 1.49 0 miRNAWalker2 validate -0.11 0.04492 NA
23 hsa-miR-28-5p AHNAK -0.14 0.04976 -1.77 0 miRanda -0.27 0 NA
24 hsa-miR-28-5p AKR7A2 -0.14 0.04976 0.34 1.0E-5 miRanda -0.24 0 NA
25 hsa-miR-143-3p AKT1 -1.23 0 0.68 0 miRNAWalker2 validate -0.11 0 NA
26 hsa-miR-28-5p ALDH3A2 -0.14 0.04976 -0.86 0 miRanda -0.29 0 NA
27 hsa-miR-28-5p AMIGO2 -0.14 0.04976 -1.58 0 miRanda -0.24 0.00784 NA
28 hsa-miR-28-5p AMPH -0.14 0.04976 -0.23 0.25767 miRanda -0.38 8.0E-5 NA
29 hsa-miR-28-5p AMZ1 -0.14 0.04976 2.49 0 miRanda -0.45 0.00014 NA
30 hsa-miR-28-5p ANGEL1 -0.14 0.04976 -0.24 5.0E-5 miRanda -0.14 0 NA
31 hsa-miR-28-5p ANKS1B -0.14 0.04976 0.2 0.2194 miRanda -0.42 0 NA
32 hsa-miR-28-5p ANKS3 -0.14 0.04976 0.72 0 miRanda -0.16 0.0011 NA
33 hsa-miR-28-5p ANXA9 -0.14 0.04976 1.78 0 miRanda -1.05 0 NA
34 hsa-miR-28-5p AP2A2 -0.14 0.04976 0.03 0.55943 miRanda -0.12 0 NA
35 hsa-miR-28-5p AP2B1 -0.14 0.04976 0.26 0.00183 miRanda -0.22 0 NA
36 hsa-miR-145-5p APH1A -2.63 0 0.88 0 miRNAWalker2 validate -0.18 0 NA
37 hsa-miR-28-5p ARAF -0.14 0.04976 0.24 1.0E-5 miRanda -0.11 4.0E-5 NA
38 hsa-miR-132-3p ARHGAP32 -0.04 0.6686 0.43 9.0E-5 miRNAWalker2 validate; miRTarBase -0.22 0 NA
39 hsa-miR-28-5p ARHGAP32 -0.14 0.04976 0.43 9.0E-5 miRanda -0.36 0 NA
40 hsa-miR-28-5p ARHGAP8 -0.14 0.04976 1.29 0 miRanda -0.12 0.04559 NA
41 hsa-miR-28-5p ARHGEF16 -0.14 0.04976 1.35 0 miRanda -0.31 0 NA
42 hsa-miR-28-5p ARL17A -0.14 0.04976 -0.08 0.37677 miRanda -0.12 0.00459 NA
43 hsa-miR-28-5p ARL6IP4 -0.14 0.04976 0.5 0 miRanda -0.19 0.00019 NA
44 hsa-miR-28-5p ARMC5 -0.14 0.04976 0.67 0 miRanda -0.28 0 NA
45 hsa-miR-28-5p ARMC7 -0.14 0.04976 0.79 0 miRanda -0.13 0.00026 NA
46 hsa-miR-28-5p ARMC9 -0.14 0.04976 1.05 0 miRanda -0.18 0 NA
47 hsa-miR-28-5p ASB8 -0.14 0.04976 -0.21 0.00012 miRanda -0.19 0 NA
48 hsa-miR-132-3p ATP6V0E1 -0.04 0.6686 0.38 0 miRNAWalker2 validate -0.1 6.0E-5 NA
49 hsa-miR-28-5p ATPAF1 -0.14 0.04976 -0.16 0.00532 miRanda -0.12 1.0E-5 NA
50 hsa-miR-28-5p ATRNL1 -0.14 0.04976 -0.74 0.02081 miRanda -0.53 0.00049 NA
51 hsa-miR-28-5p B3GALT4 -0.14 0.04976 0.46 1.0E-5 miRanda -0.14 0.00301 NA
52 hsa-miR-28-5p BAG1 -0.14 0.04976 0.42 2.0E-5 miRanda -0.31 0 NA
53 hsa-miR-28-5p BBS1 -0.14 0.04976 -0.09 0.27359 miRanda -0.29 0 NA
54 hsa-miR-28-5p BCAM -0.14 0.04976 0.51 0.00081 miRanda -0.64 0 NA
55 hsa-miR-28-5p BHLHE40 -0.14 0.04976 0.41 0.00047 miRanda -0.47 0 NA
56 hsa-let-7e-5p BMP2K 0.26 0.00191 -0.61 0 miRNAWalker2 validate -0.11 0.01434 NA
57 hsa-miR-28-5p BTRC -0.14 0.04976 0.12 0.15929 miRanda -0.25 0 NA
58 hsa-miR-28-5p CACNG4 -0.14 0.04976 2.21 0 miRanda -0.63 2.0E-5 NA
59 hsa-miR-28-5p CALCOCO1 -0.14 0.04976 -1.08 0 miRanda -0.14 8.0E-5 NA
60 hsa-miR-28-5p CALCOCO2 -0.14 0.04976 -0.44 0 miRanda -0.2 0 NA
61 hsa-miR-28-5p CANT1 -0.14 0.04976 1.19 0 miRanda -0.31 0 NA
62 hsa-miR-28-5p CASC2 -0.14 0.04976 -0.06 0.56145 miRanda -0.21 1.0E-5 NA
63 hsa-miR-132-3p CASP7 -0.04 0.6686 0.1 0.18258 miRNAWalker2 validate -0.11 0.00022 NA
64 hsa-miR-28-5p CCDC113 -0.14 0.04976 0.15 0.13693 miRanda -0.15 0.0019 NA
65 hsa-miR-28-5p CCDC114 -0.14 0.04976 1.17 0 miRanda -0.3 0.00046 NA
66 hsa-miR-28-5p CCDC85A -0.14 0.04976 -2.64 0 miRanda -0.2 0.02171 NA
67 hsa-miR-28-5p CCDC87 -0.14 0.04976 1.38 0 miRanda -0.5 0 NA
68 hsa-miR-28-5p CCNDBP1 -0.14 0.04976 -0.73 0 miRanda -0.17 0 NA
69 hsa-miR-28-5p CCNG2 -0.14 0.04976 -0.15 0.14084 miRanda -0.2 3.0E-5 NA
70 hsa-miR-132-3p CD164 -0.04 0.6686 -0.29 0.00028 miRNAWalker2 validate -0.19 0 NA
71 hsa-miR-28-5p CD2BP2 -0.14 0.04976 0.73 0 miRanda -0.24 0 NA
72 hsa-miR-132-3p CD55 -0.04 0.6686 -0.36 0.00102 miRNAWalker2 validate -0.12 0.00697 NA
73 hsa-miR-28-5p CDH18 -0.14 0.04976 -0.05 0.84157 miRanda -0.34 0.00651 NA
74 hsa-miR-28-5p CDH7 -0.14 0.04976 1.31 2.0E-5 miRanda -0.56 0.00015 NA
75 hsa-miR-28-5p CDK17 -0.14 0.04976 -0.12 0.11999 miRanda -0.27 0 NA
76 hsa-miR-145-5p CDK4 -2.63 0 0.6 0 miRNAWalker2 validate; miRTarBase -0.13 0 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control
77 hsa-miR-28-5p CDK5 -0.14 0.04976 1.49 0 miRanda -0.23 0 NA
78 hsa-miR-28-5p CDKN1A -0.14 0.04976 -0.25 0.02507 miRNAWalker2 validate; miRTarBase; miRanda -0.29 0 NA
79 hsa-miR-28-5p CDON -0.14 0.04976 -0.99 0 miRanda -0.22 0.00112 NA
80 hsa-miR-28-5p CEACAM6 -0.14 0.04976 3.15 0 miRanda -1.28 0 NA
81 hsa-miR-28-5p CEACAM7 -0.14 0.04976 1.14 7.0E-5 miRanda -1.1 0 NA
82 hsa-let-7e-5p CELF2 0.26 0.00191 -2.12 0 miRNAWalker2 validate -0.21 0.00025 NA
83 hsa-miR-28-5p CHAD -0.14 0.04976 -0 0.99305 miRanda -0.9 0 NA
84 hsa-miR-28-5p CHD3 -0.14 0.04976 0.23 0.00044 miRanda -0.15 0 NA
85 hsa-miR-28-5p CHDH -0.14 0.04976 0.09 0.50882 miRanda -0.3 1.0E-5 NA
86 hsa-miR-28-5p CLASP2 -0.14 0.04976 -0.48 0 miRanda -0.16 0 NA
87 hsa-miR-28-5p CNKSR1 -0.14 0.04976 1.45 0 miRanda -0.14 0.03787 NA
88 hsa-miR-28-5p COL3A1 -0.14 0.04976 1.5 0 miRanda -0.22 0.00939 NA
89 hsa-miR-28-5p COL6A3 -0.14 0.04976 0.63 2.0E-5 miRanda -0.14 0.04652 NA
90 hsa-miR-28-5p COMMD3 -0.14 0.04976 0.68 0 miRanda -0.13 0.00027 NA
91 hsa-miR-28-5p COPG2 -0.14 0.04976 0.25 0.00034 miRanda -0.18 0 NA
92 hsa-miR-28-5p CPD -0.14 0.04976 -0.24 0.02078 miRanda -0.26 0 NA
93 hsa-miR-28-5p CRADD -0.14 0.04976 -0.25 0.00023 miRanda -0.24 0 NA
94 hsa-miR-28-5p CREBL2 -0.14 0.04976 -0.83 0 miRanda -0.12 0.00037 NA
95 hsa-miR-28-5p CROT -0.14 0.04976 0.04 0.77707 miRanda -0.44 0 NA
96 hsa-miR-28-5p CRY2 -0.14 0.04976 -1.2 0 miRanda -0.22 0 NA
97 hsa-miR-132-3p CST9L -0.04 0.6686 0.9 0.00141 miRNAWalker2 validate -0.26 0.0255 NA
98 hsa-miR-28-5p CYTH2 -0.14 0.04976 0.7 0 miRanda -0.2 0 NA
99 hsa-miR-28-5p DALRD3 -0.14 0.04976 0.59 0 miRanda -0.45 0 NA
100 hsa-miR-28-5p DAZAP2 -0.14 0.04976 0.05 0.32954 miRanda -0.17 0 NA
101 hsa-miR-28-5p DDX60 -0.14 0.04976 0.26 0.04951 miRanda -0.12 0.04794 NA
102 hsa-miR-28-5p DHRS2 -0.14 0.04976 1.08 0.01801 miRanda -1.42 0 NA
103 hsa-miR-28-5p DHRS4 -0.14 0.04976 0.08 0.36032 miRanda -0.25 0 NA
104 hsa-miR-28-5p DHRS4L1 -0.14 0.04976 -0.1 0.44303 miRanda -0.35 0 NA
105 hsa-miR-28-5p DHRS4L2 -0.14 0.04976 -0.01 0.88566 miRanda -0.24 0 NA
106 hsa-miR-28-5p DHRS7B -0.14 0.04976 -0.23 0.00249 miRanda -0.2 0 NA
107 hsa-miR-28-5p DHX29 -0.14 0.04976 0.07 0.25412 miRanda -0.23 0 NA
108 hsa-miR-28-5p DHX58 -0.14 0.04976 0.57 0 miRanda -0.2 3.0E-5 NA
109 hsa-miR-28-5p DNAJA4 -0.14 0.04976 0.78 0 miRanda -0.37 0 NA
110 hsa-miR-28-5p DNAJB14 -0.14 0.04976 -0.39 1.0E-5 miRanda -0.13 0.00215 NA
111 hsa-miR-28-5p DNAJC12 -0.14 0.04976 1.44 0 miRanda -1.08 0 NA
112 hsa-miR-28-5p DNMBP -0.14 0.04976 -0.67 0 miRanda -0.28 0 NA
113 hsa-miR-143-3p DNMT3A -1.23 0 0.95 0 miRNAWalker2 validate; miRTarBase -0.13 0 24218337; 19638978 Ectopic expression of miR-143 inhibited proliferation and soft agar colony formation of breast cancer cells and also downregulated DNA methyltransferase 3A DNMT3A expression on both mRNA and protein levels; DNMT3A was demonstrated to be a direct target of miR-143 by luciferase reporter assay; Furthermore miR-143 expression was observed to be inversely correlated with DNMT3A mRNA and protein expression in breast cancer tissues; Our findings suggest that miR-143 regulates DNMT3A in breast cancer cells;Using in silico predictions DNA methyltranferase 3A DNMT3A was defined as a potential target of miR-143; Restoration of the miR-143 expression in colon cell lines decreased tumour cell growth and soft-agar colony formation and downregulated the DNMT3A expression in both mRNA and protein levels; DNMT3A was shown to be a direct target of miR-143 by luciferase reporter assay; Furthermore the miR-143 expression was observed to be inversely correlated with DNMT3A mRNA and protein expression in CRC tissues; Our findings suggest that miR-143 regulates DNMT3A in CRC
114 hsa-miR-28-5p DPH1 -0.14 0.04976 -0.03 0.66337 miRanda -0.14 1.0E-5 NA
115 hsa-miR-28-5p DPP3 -0.14 0.04976 1.58 0 miRanda -0.19 3.0E-5 NA
116 hsa-miR-28-5p DQX1 -0.14 0.04976 3.64 0 miRanda -0.79 0 NA
117 hsa-miR-28-5p DTWD2 -0.14 0.04976 -0.26 0.00652 miRanda -0.32 0 NA
118 hsa-miR-28-5p DYNC2LI1 -0.14 0.04976 -0 0.96365 miRanda -0.13 0 NA
119 hsa-miR-28-5p DYNLL2 -0.14 0.04976 0.06 0.38599 miRanda -0.14 8.0E-5 NA
120 hsa-miR-28-5p DYNLRB2 -0.14 0.04976 0.03 0.90674 miRanda -0.96 0 NA
121 hsa-miR-205-5p E2F1 -1.7 0 2.6 0 miRNAWalker2 validate; miRTarBase -0.15 0 22578566; 21454583 Re-expression of miR-205 where absent strongly reduces cell proliferation cell cycle progression and clonogenic potential in vitro and inhibits tumor growth in vivo and this tumor suppressor activity is at least partially exerted through targeting of E2F1 master regulator of cell cycle progression and LAMC1 component of extracellular matrix involved in cell adhesion proliferation and migration;The expression levels of E2F1 and E2F5 were correlated inversely with that of miR-205 in melanoma cell lines; miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3'-UTR sequences complementary to either E2F1 or E2F5; Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels
122 hsa-miR-28-5p EDA2R -0.14 0.04976 -1.34 0 miRanda -0.23 0.00086 NA
123 hsa-miR-200c-3p EDNRA 2.07 0 -0.14 0.24185 miRNAWalker2 validate -0.24 0 NA
124 hsa-miR-28-5p EGLN3 -0.14 0.04976 1.25 0 miRanda -0.21 0.00907 NA
125 hsa-miR-28-5p EIF2AK1 -0.14 0.04976 0.86 0 miRanda -0.14 0 NA
126 hsa-miR-28-5p EIF4E3 -0.14 0.04976 -1.14 0 miRanda -0.2 1.0E-5 NA
127 hsa-miR-28-5p ELMOD3 -0.14 0.04976 -1.18 0 miRanda -0.13 0.00085 NA
128 hsa-miR-28-5p ENOSF1 -0.14 0.04976 -0.05 0.53098 miRanda -0.12 0.00186 NA
129 hsa-miR-28-5p ENPP5 -0.14 0.04976 0.73 0.00025 miRanda -0.43 1.0E-5 NA
130 hsa-miR-28-5p EPB41L4A -0.14 0.04976 -0.67 0 miRanda -0.39 0 NA
131 hsa-miR-28-5p EPM2AIP1 -0.14 0.04976 -0.44 0 miRanda -0.14 0.00015 NA
132 hsa-miR-28-5p EPN1 -0.14 0.04976 0.76 0 miRanda -0.12 0.0021 NA
133 hsa-miR-28-5p EPN2 -0.14 0.04976 -0.03 0.69538 miRanda -0.16 0 NA
134 hsa-miR-28-5p ERAL1 -0.14 0.04976 0.6 0 miRanda -0.13 0.00024 NA
135 hsa-miR-28-5p ERGIC1 -0.14 0.04976 0.65 0 miRanda -0.42 0 NA
136 hsa-miR-28-5p ERI2 -0.14 0.04976 0.37 1.0E-5 miRanda -0.27 0 NA
137 hsa-miR-28-5p ERLIN2 -0.14 0.04976 0 0.96954 miRanda -0.25 0 NA
138 hsa-miR-200c-3p ERRFI1 2.07 0 -1.06 0 miRNAWalker2 validate; miRTarBase -0.14 0 NA
139 hsa-miR-200b-3p ETS1 2.12 0 -0.98 0 miRNAWalker2 validate; miRTarBase -0.25 0 NA
140 hsa-miR-28-5p EXOC6 -0.14 0.04976 0.31 0.00088 miRanda -0.33 0 NA
141 hsa-miR-132-3p EYA4 -0.04 0.6686 -1.71 0 miRNAWalker2 validate -0.24 0.02768 NA
142 hsa-miR-145-5p F11R -2.63 0 0.78 0 miRNAWalker2 validate -0.12 0 20818426; 26374689 Our data identify JAM-A and fascin as novel targets of miR-145 firmly establishing a role for miR-145 in modulating breast cancer cell motility;MicroRNA screening predicted that microRNA-145 miR-145 would bind to JAM-A; Using patient-derived glioblastoma CSCs we confirmed that JAM-A is suppressed by miR-145
143 hsa-miR-28-5p F2RL2 -0.14 0.04976 1.83 0 miRanda -0.46 7.0E-5 NA
144 hsa-miR-28-5p FAHD1 -0.14 0.04976 0.78 0 miRanda -0.25 0 NA
145 hsa-miR-28-5p FAM110B -0.14 0.04976 0.45 0.0022 miRanda -0.44 0 NA
146 hsa-miR-28-5p FAM134C -0.14 0.04976 0.22 0.00023 miRanda -0.18 0 NA
147 hsa-miR-28-5p FAM135B -0.14 0.04976 0.3 0.29265 miRanda -0.64 0 NA
148 hsa-miR-28-5p FAM151B -0.14 0.04976 0.35 0.00022 miRanda -0.36 0 NA
149 hsa-miR-28-5p FAM160A2 -0.14 0.04976 -0.15 0.0058 miRanda -0.12 0 NA
150 hsa-miR-28-5p FAM169A -0.14 0.04976 0 0.99613 miRanda -0.17 0.0158 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 24 278 2.687e-07 0.00125
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 GOLGI APPARATUS PART 49 893 5.735e-07 0.0001675
2 GOLGI APPARATUS 69 1445 4.976e-07 0.0001675

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 FoxO_signaling_pathway_hsa04068 15 132 1.646e-06 8.557e-05
2 Cellular_senescence_hsa04218 15 160 1.769e-05 0.0004599
3 MAPK_signaling_pathway_hsa04010 19 295 0.000256 0.004438
4 Focal_adhesion_hsa04510 14 199 0.000686 0.008919
5 PI3K_Akt_signaling_pathway_hsa04151 20 352 0.0008807 0.009159
6 Ras_signaling_pathway_hsa04014 15 232 0.001067 0.009248
7 Phospholipase_D_signaling_pathway_hsa04072 11 146 0.00145 0.00927
8 ErbB_signaling_pathway_hsa04012 8 85 0.001572 0.00927
9 p53_signaling_pathway_hsa04115 7 68 0.00182 0.00927
10 TNF_signaling_pathway_hsa04668 9 108 0.001929 0.00927
11 cAMP_signaling_pathway_hsa04024 13 198 0.001961 0.00927
12 Rap1_signaling_pathway_hsa04015 13 206 0.002772 0.01201
13 VEGF_signaling_pathway_hsa04370 6 59 0.004059 0.01624
14 Mitophagy_animal_hsa04137 6 65 0.00654 0.02429
15 Regulation_of_actin_cytoskeleton_hsa04810 12 208 0.007981 0.02767
16 Endocytosis_hsa04144 13 244 0.01111 0.03609
17 AMPK_signaling_pathway_hsa04152 8 121 0.01322 0.04045
18 Phosphatidylinositol_signaling_system_hsa04070 7 99 0.01419 0.04086
19 HIF_1_signaling_pathway_hsa04066 7 100 0.01493 0.04086
20 Peroxisome_hsa04146 6 83 0.02035 0.0529
21 Jak_STAT_signaling_pathway_hsa04630 9 162 0.02494 0.06071
22 Gap_junction_hsa04540 6 88 0.02628 0.06071
23 Apoptosis_hsa04210 8 138 0.02685 0.06071
24 Sphingolipid_signaling_pathway_hsa04071 7 118 0.03333 0.07222
25 mTOR_signaling_pathway_hsa04150 8 151 0.04232 0.08803
26 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 7 139 0.06887 0.1377
27 Autophagy_animal_hsa04140 6 128 0.1141 0.2197
28 Hedgehog_signaling_pathway_hsa04340 3 47 0.1208 0.2243
29 Notch_signaling_pathway_hsa04330 3 48 0.1265 0.2268
30 Apelin_signaling_pathway_hsa04371 6 137 0.1437 0.2491
31 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.1714 0.2876
32 Calcium_signaling_pathway_hsa04020 7 182 0.1916 0.3114
33 Cell_cycle_hsa04110 5 124 0.2169 0.3418
34 Tight_junction_hsa04530 6 170 0.2759 0.422
35 Adherens_junction_hsa04520 3 72 0.2842 0.4223
36 ABC_transporters_hsa02010 2 45 0.324 0.4681
37 ECM_receptor_interaction_hsa04512 3 82 0.355 0.499
38 Hippo_signaling_pathway_hsa04390 5 154 0.3658 0.5006
39 Lysosome_hsa04142 4 123 0.3922 0.5229
40 Cell_adhesion_molecules_.CAMs._hsa04514 4 145 0.5169 0.672
41 Cytokine_cytokine_receptor_interaction_hsa04060 7 270 0.5481 0.6951
42 Neuroactive_ligand_receptor_interaction_hsa04080 7 278 0.5791 0.7003
43 cGMP_PKG_signaling_pathway_hsa04022 4 163 0.6094 0.7202
44 Oocyte_meiosis_hsa04114 3 124 0.624 0.721
45 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.7072 0.7995
46 Wnt_signaling_pathway_hsa04310 3 146 0.7305 0.8083
47 Necroptosis_hsa04217 3 164 0.7988 0.8654

Quest ID: 1373ec332bc1d92f44f09625d49e5bb7