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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-125b-5p AIFM1 0.04 0.98059 -0.13 0.93316 miRNATAP -0.07 0.04571 NA
2 hsa-miR-125b-5p AKT1 0.04 0.98059 -0.06 0.97402 miRNAWalker2 validate; miRTarBase -0.06 0.00668 NA
3 hsa-miR-106a-5p AKT3 -0.2 0.80221 0.46 0.53933 miRNATAP -0.55 0 NA
4 hsa-miR-106b-5p AKT3 -0.3 0.86929 0.46 0.53933 miRNATAP -0.91 0 NA
5 hsa-miR-107 AKT3 -0.04 0.98836 0.46 0.53933 PITA; miRanda -0.55 0.00017 NA
6 hsa-miR-1275 AKT3 -0.83 0.08038 0.46 0.53933 PITA -0.27 0 NA
7 hsa-miR-140-5p AKT3 -0.23 0.84733 0.46 0.53933 miRanda -0.29 0.02297 NA
8 hsa-miR-142-3p AKT3 -0.15 0.9461 0.46 0.53933 miRanda -0.2 0.00627 NA
9 hsa-miR-15a-5p AKT3 -0.07 0.96484 0.46 0.53933 miRNAWalker2 validate; miRTarBase; miRNATAP -0.72 0 NA
10 hsa-miR-15b-5p AKT3 -0.27 0.87097 0.46 0.53933 miRNATAP -0.67 0 NA
11 hsa-miR-16-5p AKT3 0.01 0.99448 0.46 0.53933 miRNAWalker2 validate; miRTarBase; miRNATAP -0.75 0 NA
12 hsa-miR-17-3p AKT3 0.1 0.96011 0.46 0.53933 miRNATAP -0.52 0 NA
13 hsa-miR-17-5p AKT3 -0.18 0.93454 0.46 0.53933 TargetScan; miRNATAP -0.63 0 NA
14 hsa-miR-181b-5p AKT3 0.16 0.93018 0.46 0.53933 miRNATAP -0.27 0.00963 NA
15 hsa-miR-20a-5p AKT3 -0.18 0.92812 0.46 0.53933 miRNATAP -0.53 0 NA
16 hsa-miR-28-3p AKT3 -0.23 0.93535 0.46 0.53933 miRNATAP -0.52 0.00719 NA
17 hsa-miR-29a-3p AKT3 0.01 0.99698 0.46 0.53933 miRNATAP -0.81 0 NA
18 hsa-miR-29b-3p AKT3 -0.1 0.95899 0.46 0.53933 miRNATAP -0.68 0 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
19 hsa-miR-32-3p AKT3 -0.57 0.13133 0.46 0.53933 mirMAP -0.56 0 NA
20 hsa-miR-320a AKT3 -0.42 0.8402 0.46 0.53933 PITA; miRanda; miRNATAP -0.33 0.00138 NA
21 hsa-miR-320b AKT3 -0.24 0.85922 0.46 0.53933 PITA; miRanda; miRNATAP -0.25 0.00855 NA
22 hsa-miR-320c AKT3 -0.58 0.1136 0.46 0.53933 PITA; miRanda; miRNATAP -0.17 0.01525 NA
23 hsa-miR-335-3p AKT3 -0.24 0.8845 0.46 0.53933 mirMAP -0.58 0 NA
24 hsa-miR-33a-3p AKT3 -0.79 0.01052 0.46 0.53933 mirMAP -0.49 0 NA
25 hsa-miR-340-5p AKT3 -0 0.99757 0.46 0.53933 mirMAP -0.28 0.006 NA
26 hsa-miR-362-3p AKT3 -0.72 0.03459 0.46 0.53933 miRanda -0.42 0 NA
27 hsa-miR-362-5p AKT3 -0.27 0.75202 0.46 0.53933 PITA; TargetScan; miRNATAP -0.52 0 NA
28 hsa-miR-369-3p AKT3 0.12 0.8323 0.46 0.53933 mirMAP -0.23 0.00901 NA
29 hsa-miR-374a-5p AKT3 -0.34 0.76692 0.46 0.53933 mirMAP -0.58 0 NA
30 hsa-miR-374b-5p AKT3 -0.29 0.8357 0.46 0.53933 mirMAP -0.68 0 NA
31 hsa-miR-421 AKT3 -0.18 0.7347 0.46 0.53933 miRanda; mirMAP -0.46 0 NA
32 hsa-miR-424-5p AKT3 0.25 0.87015 0.46 0.53933 miRNATAP -0.24 0.00104 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth
33 hsa-miR-501-3p AKT3 -0.75 0.55276 0.46 0.53933 miRNATAP -0.5 0 NA
34 hsa-miR-502-3p AKT3 -0.48 0.5143 0.46 0.53933 miRNATAP -0.64 0 NA
35 hsa-miR-502-5p AKT3 -0.71 0.02613 0.46 0.53933 PITA; miRNATAP -0.41 0 NA
36 hsa-miR-505-3p AKT3 -0.47 0.69038 0.46 0.53933 mirMAP -0.77 0 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR
37 hsa-miR-539-5p AKT3 0.12 0.80107 0.46 0.53933 mirMAP; miRNATAP -0.19 0.0467 NA
38 hsa-miR-548o-3p AKT3 -0.19 0.51773 0.46 0.53933 mirMAP -0.31 8.0E-5 NA
39 hsa-miR-577 AKT3 -1.06 0.32606 0.46 0.53933 mirMAP -0.38 0 NA
40 hsa-miR-663b AKT3 0.1 0.81499 0.46 0.53933 PITA -0.25 1.0E-5 NA
41 hsa-miR-769-5p AKT3 -0.31 0.7357 0.46 0.53933 PITA; miRNATAP -0.84 0 NA
42 hsa-miR-93-5p AKT3 -0.61 0.8253 0.46 0.53933 miRNATAP -0.76 0 NA
43 hsa-miR-708-3p APAF1 0.14 0.89698 -0.17 0.88665 mirMAP -0.11 0.0011 NA
44 hsa-miR-146b-5p ATM -0.4 0.83751 0.19 0.86463 miRanda -0.09 0.03968 27602131 The role of microRNA 146b miR-146b in ATC remains to be elucidated; In order to characterize the role of miR-146b in ATC overexpression or interference of miR-146b was induced in ATC cell lines and cell proliferation and migration were evaluated; The potential targets of miR-146b were searched in the Gene Expression Omnibus database for ATC and matched non-tumor control samples; The expression level of potential targets was detected following overexpression or interference of miR-146b in ATC cell lines; In addition cell migration of ATC was also affected by miR-146b; During the search for potential targets of miR-146b in ATC p21 also known as p21Waf1/Cip1 or CDKN1A was noted for its role in cell cycle progression and tumor pathogenesis; In conclusion p21 may participate in the regulation of ATC cell proliferation by miR-146b
45 hsa-miR-18a-5p ATM -0.5 0.61264 0.19 0.86463 miRNAWalker2 validate; miRTarBase; MirTarget -0.07 0.00927 23229340; 23437304; 25963391; 23857602 MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases;MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer
46 hsa-miR-21-5p ATM -0.15 0.97024 0.19 0.86463 mirMAP -0.12 0.04916 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy
47 hsa-miR-26b-5p ATM -0.02 0.99038 0.19 0.86463 MirTarget -0.1 0.03639 NA
48 hsa-miR-29a-5p ATM -0.32 0.60044 0.19 0.86463 mirMAP -0.08 0.01391 NA
49 hsa-miR-324-5p ATM -0.5 0.53742 0.19 0.86463 miRanda -0.12 0.00155 NA
50 hsa-miR-339-5p ATM -0.3 0.71291 0.19 0.86463 miRanda -0.07 0.02232 NA
51 hsa-miR-362-3p ATM -0.72 0.03459 0.19 0.86463 miRanda -0.07 0.02113 NA
52 hsa-miR-455-5p ATM -0.14 0.86574 0.19 0.86463 miRanda -0.12 0.00128 NA
53 hsa-miR-576-5p ATM -0.51 0.41719 0.19 0.86463 mirMAP -0.09 0.01709 NA
54 hsa-miR-577 ATM -1.06 0.32606 0.19 0.86463 PITA -0.06 0.00179 NA
55 hsa-miR-590-3p ATM -0.28 0.59127 0.19 0.86463 miRanda; mirMAP -0.06 0.03618 NA
56 hsa-miR-590-5p ATM -0.55 0.47274 0.19 0.86463 mirMAP -0.1 0.00142 NA
57 hsa-miR-129-5p BAD 0.27 0.55335 0.1 0.93266 miRanda -0.07 0.00168 NA
58 hsa-miR-153-3p BCL2 -0.5 0.30683 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.12 0.0323 19676043; 21213215 Bioinformatics analysis revealed that anti-apoptosis family member B-cell lymphoma 2 Bcl-2 and myeloid cell leukemia sequence 1 Mcl-1 are potential targets of miR-153; Indeed Western blot analysis indicated that miR-153 downregulated both Bcl-2 and Mcl-1 at the protein levels; By luciferase reporter assays we further showed that miR-153 inhibited Bcl-2 and Mcl-1 expressions by directly targeting the 3'UTR regions of their respective mRNAs;Previously we established that microRNA-153 miR-153 induces apoptosis by downregulating B-cell lymphoma 2 Bcl-2 and myeloid cell leukemia sequence 1 Mcl-1 protein expression levels in glioblastoma cell line DBTRG-05MG
59 hsa-miR-15a-5p BCL2 -0.07 0.96484 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.22 0.02911 25623762; 25594541; 26915294; 18931683; 22335947 miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05
60 hsa-miR-16-5p BCL2 0.01 0.99448 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.23 0.01553 25623762; 21336967; 24447552; 18449891; 25435430; 24598659; 18931683; 22966344 miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene
61 hsa-miR-17-5p BCL2 -0.18 0.93454 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.31 2.0E-5 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2
62 hsa-miR-192-5p BCL2 -0.12 0.97293 -0.87 0.24496 miRNAWalker2 validate -0.23 0.00056 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192
63 hsa-miR-196b-5p BCL2 -0.08 0.97211 -0.87 0.24496 miRNAWalker2 validate -0.13 0.00926 NA
64 hsa-miR-20a-3p BCL2 0.46 0.57674 -0.87 0.24496 mirMAP -0.19 0.00115 NA
65 hsa-miR-20a-5p BCL2 -0.18 0.92812 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.25 0.00046 NA
66 hsa-miR-224-3p BCL2 0.11 0.74909 -0.87 0.24496 mirMAP -0.18 0.00775 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01
67 hsa-miR-224-5p BCL2 -0.24 0.85735 -0.87 0.24496 mirMAP -0.3 0 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01
68 hsa-miR-24-2-5p BCL2 -0.09 0.92016 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.41 0.00012 NA
69 hsa-miR-29a-3p BCL2 0.01 0.99698 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.34 0.00194 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29
70 hsa-miR-29a-5p BCL2 -0.32 0.60044 -0.87 0.24496 mirMAP -0.34 1.0E-5 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29
71 hsa-miR-29b-3p BCL2 -0.1 0.95899 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.27 0.00119 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29
72 hsa-miR-335-3p BCL2 -0.24 0.8845 -0.87 0.24496 mirMAP -0.25 0.00118 NA
73 hsa-miR-33a-5p BCL2 -0.21 0.85331 -0.87 0.24496 mirMAP -0.13 0.00456 NA
74 hsa-miR-374b-5p BCL2 -0.29 0.8357 -0.87 0.24496 mirMAP -0.29 0.0137 NA
75 hsa-miR-450b-5p BCL2 -0.01 0.98315 -0.87 0.24496 mirMAP -0.24 0.00586 NA
76 hsa-miR-452-5p BCL2 -0.05 0.97387 -0.87 0.24496 mirMAP -0.28 0.00061 NA
77 hsa-miR-590-5p BCL2 -0.55 0.47274 -0.87 0.24496 miRanda -0.18 0.01554 NA
78 hsa-miR-7-5p BCL2 0.21 0.77371 -0.87 0.24496 miRNAWalker2 validate; miRTarBase; mirMAP -0.2 0.00018 26464649; 25862909; 21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions
79 hsa-let-7a-5p BCL2L1 -0.06 0.98501 0.24 0.89096 TargetScan; miRNATAP -0.27 0.0015 26915294; 20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA
80 hsa-miR-326 BCL2L1 -0.57 0.6207 0.24 0.89096 PITA; miRanda; mirMAP; miRNATAP -0.1 0.03992 NA
81 hsa-miR-511-5p BID -0.31 0.6072 -0.06 0.96523 MirTarget -0.09 0.00371 NA
82 hsa-miR-126-5p BIRC2 0.08 0.95664 -0.01 0.9934 mirMAP -0.12 0.00073 NA
83 hsa-miR-29b-3p BIRC2 -0.1 0.95899 -0.01 0.9934 MirTarget -0.07 0.01456 NA
84 hsa-miR-421 BIRC2 -0.18 0.7347 -0.01 0.9934 miRanda -0.05 0.03914 NA
85 hsa-miR-500a-5p BIRC2 -0.72 0.18807 -0.01 0.9934 MirTarget -0.07 0.00207 NA
86 hsa-miR-24-1-5p BIRC3 -0.19 0.79153 -0.14 0.89724 MirTarget -0.31 0.00145 NA
87 hsa-miR-24-2-5p BIRC3 -0.09 0.92016 -0.14 0.89724 MirTarget -0.21 0.0414 NA
88 hsa-miR-374a-5p BIRC3 -0.34 0.76692 -0.14 0.89724 mirMAP -0.23 0.04767 NA
89 hsa-miR-374b-5p BIRC3 -0.29 0.8357 -0.14 0.89724 mirMAP -0.28 0.01092 NA
90 hsa-miR-651-5p BIRC3 -0.57 0.17254 -0.14 0.89724 MirTarget -0.16 0.00706 NA
91 hsa-miR-20a-3p CAPN2 0.46 0.57674 0.04 0.98149 MirTarget -0.11 0.00146 NA
92 hsa-miR-421 CAPN2 -0.18 0.7347 0.04 0.98149 miRanda -0.25 0 NA
93 hsa-miR-7-5p CAPN2 0.21 0.77371 0.04 0.98149 miRNAWalker2 validate -0.12 0.0001 NA
94 hsa-miR-125b-5p CASP10 0.04 0.98059 -0.29 0.80713 mirMAP -0.09 0.02233 NA
95 hsa-miR-129-5p CASP10 0.27 0.55335 -0.29 0.80713 mirMAP -0.07 0.04141 NA
96 hsa-miR-145-3p CASP10 0.13 0.91316 -0.29 0.80713 mirMAP -0.13 0.02504 NA
97 hsa-miR-181c-5p CASP10 0.04 0.96916 -0.29 0.80713 mirMAP -0.15 0.00318 NA
98 hsa-miR-217 CASP10 0.34 0.761 -0.29 0.80713 mirMAP -0.08 0.04379 NA
99 hsa-miR-592 CASP10 -0.18 0.85623 -0.29 0.80713 miRNATAP -0.06 0.00746 NA
100 hsa-let-7c-5p CASP3 -0.06 0.9749 -0.16 0.90316 MirTarget -0.09 0.00056 NA
101 hsa-miR-129-5p CASP3 0.27 0.55335 -0.16 0.90316 mirMAP -0.06 0.01293 23744359 The intrinsic apoptotic pathway triggered by miR-129 was activated by cleavage of caspase-9 and caspase-3
102 hsa-miR-139-5p CASP3 -0.08 0.92869 -0.16 0.90316 miRanda -0.08 0.02481 NA
103 hsa-miR-195-3p CASP3 0.12 0.69192 -0.16 0.90316 MirTarget -0.06 0.03633 NA
104 hsa-miR-30a-5p CASP3 0.22 0.93395 -0.16 0.90316 miRNATAP -0.2 6.0E-5 NA
105 hsa-miR-125a-3p CASP6 0.15 0.72476 -0.2 0.87497 miRanda -0.08 0.01942 NA
106 hsa-miR-125a-5p CASP6 -0 0.99916 -0.2 0.87497 miRanda -0.13 0.02252 NA
107 hsa-miR-129-5p CASP8 0.27 0.55335 -0.27 0.82859 miRanda -0.05 0.00484 NA
108 hsa-miR-143-3p CASP8 0.37 0.92734 -0.27 0.82859 MirTarget -0.11 0.00055 NA
109 hsa-miR-130b-3p CFLAR -0.22 0.82466 -0.06 0.9614 mirMAP -0.17 0 NA
110 hsa-miR-15b-5p CFLAR -0.27 0.87097 -0.06 0.9614 mirMAP -0.09 0.00996 NA
111 hsa-miR-16-5p CFLAR 0.01 0.99448 -0.06 0.9614 mirMAP -0.08 0.02227 NA
112 hsa-miR-2110 CFLAR -0.32 0.25098 -0.06 0.9614 MirTarget -0.06 0.03576 NA
113 hsa-miR-301a-3p CFLAR -0.11 0.83169 -0.06 0.9614 mirMAP -0.1 0.00032 NA
114 hsa-miR-30c-1-3p CFLAR -0.2 0.51149 -0.06 0.9614 mirMAP -0.08 0.00392 NA
115 hsa-miR-339-5p CFLAR -0.3 0.71291 -0.06 0.9614 miRanda -0.08 0.00348 NA
116 hsa-miR-374a-5p CFLAR -0.34 0.76692 -0.06 0.9614 MirTarget -0.1 0.02281 NA
117 hsa-miR-374b-5p CFLAR -0.29 0.8357 -0.06 0.9614 MirTarget -0.16 0.00035 NA
118 hsa-miR-421 CFLAR -0.18 0.7347 -0.06 0.9614 miRanda -0.11 0.00016 NA
119 hsa-miR-454-3p CFLAR -0.1 0.84355 -0.06 0.9614 mirMAP -0.1 0.0097 NA
120 hsa-miR-484 CFLAR -0.18 0.88633 -0.06 0.9614 mirMAP -0.1 0.01431 NA
121 hsa-miR-660-5p CFLAR -0.48 0.69408 -0.06 0.9614 mirMAP -0.08 0.01416 NA
122 hsa-miR-1254 CHP2 -0.49 0.19552 1.47 0.1548 miRNATAP -0.41 0.02445 NA
123 hsa-miR-152-3p CHUK 0.2 0.90976 -0.1 0.93218 MirTarget -0.1 0.04028 NA
124 hsa-miR-23b-3p CHUK -0.11 0.96135 -0.1 0.93218 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.14 0.00997 NA
125 hsa-miR-339-5p CHUK -0.3 0.71291 -0.1 0.93218 miRanda -0.06 0.00768 NA
126 hsa-miR-376c-3p CHUK 0.31 0.55869 -0.1 0.93218 MirTarget -0.07 0.00486 NA
127 hsa-miR-497-5p CHUK -0.01 0.98915 -0.1 0.93218 MirTarget -0.1 0.0051 NA
128 hsa-miR-15b-3p CSF2RB -0.56 0.60918 -0.42 0.60801 mirMAP -0.56 0 NA
129 hsa-miR-186-5p CSF2RB -0.32 0.85413 -0.42 0.60801 mirMAP -0.53 0.00037 NA
130 hsa-miR-19a-3p CSF2RB -0.21 0.84464 -0.42 0.60801 MirTarget -0.51 0 NA
131 hsa-miR-19b-3p CSF2RB -0.03 0.98666 -0.42 0.60801 MirTarget -0.67 0 NA
132 hsa-miR-30b-3p CSF2RB -0.51 0.16242 -0.42 0.60801 MirTarget -0.43 2.0E-5 NA
133 hsa-miR-452-3p CSF2RB -0.17 0.79901 -0.42 0.60801 mirMAP -0.43 0 NA
134 hsa-miR-532-5p CSF2RB -0.35 0.87895 -0.42 0.60801 MirTarget -0.37 0.00041 NA
135 hsa-miR-576-5p CSF2RB -0.51 0.41719 -0.42 0.60801 miRNATAP -0.36 0.0007 NA
136 hsa-miR-590-3p CSF2RB -0.28 0.59127 -0.42 0.60801 miRanda; mirMAP -0.39 1.0E-5 NA
137 hsa-miR-625-5p CSF2RB -0.69 0.21031 -0.42 0.60801 MirTarget -0.29 0.00017 NA
138 hsa-miR-139-5p CYCS -0.08 0.92869 -0.08 0.96574 miRanda -0.18 7.0E-5 NA
139 hsa-miR-20b-5p CYCS 0.15 0.74358 -0.08 0.96574 mirMAP -0.06 0.04037 NA
140 hsa-miR-34c-3p CYCS -0.07 0.82545 -0.08 0.96574 mirMAP -0.1 0.008 NA
141 hsa-miR-34c-5p CYCS -0.02 0.95279 -0.08 0.96574 miRanda -0.16 0.00033 NA
142 hsa-miR-127-3p DFFA 0.08 0.97263 -0.29 0.79395 miRanda -0.09 0.02433 NA
143 hsa-miR-129-5p DFFA 0.27 0.55335 -0.29 0.79395 miRanda; mirMAP -0.05 0.02088 NA
144 hsa-miR-145-5p DFFA 0.04 0.98758 -0.29 0.79395 miRNAWalker2 validate; miRTarBase -0.09 0.00132 NA
145 hsa-miR-26a-5p DFFA 0.01 0.99772 -0.29 0.79395 mirMAP -0.17 0.00684 NA
146 hsa-miR-30a-3p DFFA 0.25 0.91709 -0.29 0.79395 mirMAP -0.15 0.00034 NA
147 hsa-miR-34c-5p DFFA -0.02 0.95279 -0.29 0.79395 miRanda -0.11 0.00077 NA
148 hsa-miR-377-5p DFFA -0.18 0.59429 -0.29 0.79395 mirMAP -0.06 0.01588 NA
149 hsa-miR-664a-3p DFFA -0 0.99612 -0.29 0.79395 mirMAP -0.14 0.00043 NA
150 hsa-miR-199a-5p DFFB 0.16 0.9358 -0.38 0.65788 miRanda -0.08 0.0348 NA
NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF RESPONSE TO STIMULUS 46 1929 7.319e-33 3.406e-29
2 INTRACELLULAR SIGNAL TRANSDUCTION 43 1572 1.497e-32 3.482e-29
3 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 43 1848 1.258e-29 1.951e-26
4 CELL DEATH 34 1001 1.341e-27 1.248e-24
5 POSITIVE REGULATION OF MOLECULAR FUNCTION 41 1791 1.333e-27 1.248e-24
6 RESPONSE TO OXYGEN CONTAINING COMPOUND 37 1381 9.658e-27 6.42e-24
7 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 38 1492 8.338e-27 6.42e-24
8 REGULATION OF CELL DEATH 37 1472 9.284e-26 5.4e-23
9 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 17 99 1.733e-25 8.959e-23
10 RESPONSE TO CYTOKINE 29 714 2.606e-25 1.212e-22
11 POSITIVE REGULATION OF CELL COMMUNICATION 37 1532 3.807e-25 1.476e-22
12 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 38 1656 3.674e-25 1.476e-22
13 APOPTOTIC SIGNALING PATHWAY 22 289 6.858e-25 2.455e-22
14 POSITIVE REGULATION OF CATALYTIC ACTIVITY 36 1518 4.55e-24 1.512e-21
15 IMMUNE SYSTEM PROCESS 39 1984 1.724e-23 5.346e-21
16 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 29 876 8.211e-23 2.388e-20
17 RESPONSE TO NITROGEN COMPOUND 28 859 8.825e-22 2.415e-19
18 REGULATION OF IMMUNE SYSTEM PROCESS 33 1403 1.224e-21 3.164e-19
19 NEGATIVE REGULATION OF CELL DEATH 28 872 1.321e-21 3.236e-19
20 EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 12 39 1.412e-21 3.286e-19
21 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 18 213 3.512e-21 7.783e-19
22 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 17 179 6.7e-21 1.417e-18
23 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 18 233 1.804e-20 3.581e-18
24 CELLULAR RESPONSE TO CYTOKINE STIMULUS 24 606 1.847e-20 3.581e-18
25 REGULATION OF KINASE ACTIVITY 26 776 2.015e-20 3.751e-18
26 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 14 95 4.325e-20 7.741e-18
27 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 14 98 6.856e-20 1.182e-17
28 REGULATION OF TRANSFERASE ACTIVITY 27 946 1.84e-19 3.058e-17
29 REGULATION OF IMMUNE RESPONSE 26 858 2.447e-19 3.926e-17
30 ZYMOGEN ACTIVATION 14 112 4.886e-19 7.577e-17
31 RESPONSE TO ENDOGENOUS STIMULUS 31 1450 5.865e-19 8.804e-17
32 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 25 799 6.917e-19 1.006e-16
33 PHOSPHORYLATION 29 1228 9.02e-19 1.272e-16
34 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 15 153 1.032e-18 1.413e-16
35 POSITIVE REGULATION OF KINASE ACTIVITY 21 482 1.079e-18 1.434e-16
36 POSITIVE REGULATION OF IMMUNE RESPONSE 22 563 1.378e-18 1.781e-16
37 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 28 1135 1.454e-18 1.829e-16
38 ACTIVATION OF IMMUNE RESPONSE 20 427 2.061e-18 2.524e-16
39 REGULATION OF APOPTOTIC SIGNALING PATHWAY 19 363 2.15e-18 2.565e-16
40 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 34 1977 4.305e-18 5.008e-16
41 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 25 867 4.81e-18 5.459e-16
42 CYTOKINE MEDIATED SIGNALING PATHWAY 20 452 6.254e-18 6.856e-16
43 POSITIVE REGULATION OF CELL DEATH 22 605 6.336e-18 6.856e-16
44 ACTIVATION OF PROTEIN KINASE ACTIVITY 17 279 1.349e-17 1.405e-15
45 REGULATION OF PHOSPHORUS METABOLIC PROCESS 31 1618 1.359e-17 1.405e-15
46 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 26 1036 2.501e-17 2.476e-15
47 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 26 1036 2.501e-17 2.476e-15
48 PROTEIN PHOSPHORYLATION 25 944 3.573e-17 3.463e-15
49 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 14 154 4.851e-17 4.606e-15
50 CELLULAR RESPONSE TO NITROGEN COMPOUND 20 505 5.366e-17 4.993e-15
51 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 21 616 1.549e-16 1.413e-14
52 REGULATION OF PROTEOLYSIS 22 711 1.881e-16 1.683e-14
53 REGULATION OF PEPTIDASE ACTIVITY 18 392 1.954e-16 1.716e-14
54 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 14 171 2.149e-16 1.851e-14
55 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 19 470 2.575e-16 2.179e-14
56 REGULATION OF PROTEIN MODIFICATION PROCESS 30 1710 6.517e-16 5.415e-14
57 POSITIVE REGULATION OF DEFENSE RESPONSE 17 364 1.152e-15 9.407e-14
58 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 14 200 1.951e-15 1.565e-13
59 TOLL LIKE RECEPTOR SIGNALING PATHWAY 11 85 2.589e-15 2.008e-13
60 ACTIVATION OF INNATE IMMUNE RESPONSE 14 204 2.574e-15 2.008e-13
61 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 16 321 3.254e-15 2.482e-13
62 PROTEIN MATURATION 15 265 4.092e-15 3.057e-13
63 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 13 4.139e-15 3.057e-13
64 POSITIVE REGULATION OF PROTEOLYSIS 16 363 2.21e-14 1.607e-12
65 RESPONSE TO ABIOTIC STIMULUS 23 1024 3.174e-14 2.272e-12
66 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 14 246 3.47e-14 2.447e-12
67 PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 11 109 4.392e-14 3.05e-12
68 POSITIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 17 4.645e-14 3.178e-12
69 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 15 323 7.494e-14 5.054e-12
70 REGULATION OF RESPONSE TO STRESS 26 1468 1.023e-13 6.802e-12
71 HOMEOSTATIC PROCESS 25 1337 1.085e-13 7.111e-12
72 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 8 34 1.188e-13 7.677e-12
73 NEURON APOPTOTIC PROCESS 8 35 1.536e-13 9.791e-12
74 RESPONSE TO BIOTIC STIMULUS 21 886 2.004e-13 1.26e-11
75 RESPONSE TO HORMONE 21 893 2.333e-13 1.447e-11
76 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 13 228 3.064e-13 1.876e-11
77 REGULATION OF INNATE IMMUNE RESPONSE 15 357 3.207e-13 1.938e-11
78 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 15 360 3.62e-13 2.16e-11
79 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 11 132 3.745e-13 2.206e-11
80 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 22 4.022e-13 2.323e-11
81 RESPONSE TO TUMOR NECROSIS FACTOR 13 233 4.044e-13 2.323e-11
82 FC EPSILON RECEPTOR SIGNALING PATHWAY 11 142 8.417e-13 4.776e-11
83 REGULATION OF CELLULAR PROTEIN LOCALIZATION 17 552 1.018e-12 5.706e-11
84 I KAPPAB KINASE NF KAPPAB SIGNALING 9 70 1.093e-12 6.055e-11
85 WOUND HEALING 16 470 1.165e-12 6.376e-11
86 RESPONSE TO WOUNDING 17 563 1.395e-12 7.549e-11
87 REGULATION OF DEFENSE RESPONSE 19 759 1.417e-12 7.579e-11
88 CHEMICAL HOMEOSTASIS 20 874 1.652e-12 8.662e-11
89 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 8 46 1.657e-12 8.662e-11
90 RESPONSE TO PEPTIDE 15 404 1.903e-12 9.839e-11
91 NEURON DEATH 8 47 1.992e-12 1.018e-10
92 RESPONSE TO LIPID 20 888 2.21e-12 1.118e-10
93 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 21 1008 2.385e-12 1.193e-10
94 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 8 49 2.842e-12 1.407e-10
95 CELLULAR RESPONSE TO STRESS 25 1565 3.636e-12 1.781e-10
96 CELLULAR RESPONSE TO MECHANICAL STIMULUS 9 80 3.802e-12 1.843e-10
97 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 16 514 4.505e-12 2.161e-10
98 RESPONSE TO BACTERIUM 16 528 6.748e-12 3.204e-10
99 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 8 55 7.56e-12 3.518e-10
100 EXECUTION PHASE OF APOPTOSIS 8 55 7.56e-12 3.518e-10
101 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 7 32 7.743e-12 3.532e-10
102 NEGATIVE REGULATION OF SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 7 32 7.743e-12 3.532e-10
103 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 14 370 8.921e-12 4.03e-10
104 SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 7 33 9.803e-12 4.344e-10
105 EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 7 33 9.803e-12 4.344e-10
106 INFLAMMATORY RESPONSE 15 454 1.004e-11 4.405e-10
107 ACTIVATION OF PROTEIN KINASE A ACTIVITY 6 17 1.016e-11 4.42e-10
108 REGULATION OF CELL PROLIFERATION 24 1496 1.061e-11 4.572e-10
109 RESPONSE TO EXTERNAL STIMULUS 26 1821 1.441e-11 6.151e-10
110 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 10 144 2.968e-11 1.256e-09
111 POSITIVE REGULATION OF HYDROLASE ACTIVITY 19 905 3.01e-11 1.262e-09
112 CELLULAR RESPONSE TO ABIOTIC STIMULUS 12 263 3.726e-11 1.548e-09
113 RESPONSE TO ORGANIC CYCLIC COMPOUND 19 917 3.774e-11 1.554e-09
114 FC RECEPTOR SIGNALING PATHWAY 11 206 4.888e-11 1.995e-09
115 INTRINSIC APOPTOTIC SIGNALING PATHWAY 10 152 5.084e-11 2.057e-09
116 REGULATION OF HYDROLASE ACTIVITY 22 1327 5.493e-11 2.203e-09
117 CELLULAR RESPONSE TO PEPTIDE 12 274 5.994e-11 2.384e-09
118 CELLULAR GLUCOSE HOMEOSTASIS 8 75 9.965e-11 3.929e-09
119 IMMUNE RESPONSE 20 1100 1.048e-10 4.099e-09
120 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 12 289 1.11e-10 4.303e-09
121 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 13 365 1.143e-10 4.394e-09
122 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 9 118 1.334e-10 5.088e-09
123 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 6 25 1.426e-10 5.394e-09
124 GLUCOSE HOMEOSTASIS 10 170 1.539e-10 5.728e-09
125 CARBOHYDRATE HOMEOSTASIS 10 170 1.539e-10 5.728e-09
126 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 9 120 1.552e-10 5.733e-09
127 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 9 121 1.673e-10 6.129e-09
128 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 7 50 2.197e-10 7.985e-09
129 NIK NF KAPPAB SIGNALING 8 83 2.284e-10 8.237e-09
130 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 7 51 2.54e-10 9.091e-09
131 RESPONSE TO OXYGEN LEVELS 12 311 2.58e-10 9.094e-09
132 HEMOSTASIS 12 311 2.58e-10 9.094e-09
133 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 9 129 2.975e-10 1.041e-08
134 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 6 28 3.011e-10 1.045e-08
135 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 6 29 3.786e-10 1.295e-08
136 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 6 29 3.786e-10 1.295e-08
137 NEGATIVE REGULATION OF CELL COMMUNICATION 20 1192 4.325e-10 1.469e-08
138 POSITIVE REGULATION OF TRANSPORT 18 936 4.631e-10 1.561e-08
139 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 6 30 4.721e-10 1.58e-08
140 PROTEOLYSIS 20 1208 5.462e-10 1.815e-08
141 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 10 195 5.908e-10 1.922e-08
142 REGULATION OF PROTEIN LOCALIZATION 18 950 5.874e-10 1.922e-08
143 LIPOPOLYSACCHARIDE MEDIATED SIGNALING PATHWAY 6 31 5.84e-10 1.922e-08
144 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 21 1360 6.338e-10 2.048e-08
145 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 8 95 6.83e-10 2.192e-08
146 CELLULAR RESPONSE TO EXTERNAL STIMULUS 11 264 6.899e-10 2.199e-08
147 REGULATION OF INTRACELLULAR TRANSPORT 15 621 7.932e-10 2.511e-08
148 REGULATION OF CATABOLIC PROCESS 16 731 8.189e-10 2.574e-08
149 T CELL APOPTOTIC PROCESS 5 15 8.382e-10 2.617e-08
150 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 6 33 8.741e-10 2.712e-08
151 T CELL RECEPTOR SIGNALING PATHWAY 9 146 8.989e-10 2.77e-08
152 RENAL WATER HOMEOSTASIS 6 34 1.059e-09 3.241e-08
153 RESPONSE TO MECHANICAL STIMULUS 10 210 1.215e-09 3.671e-08
154 RENAL SYSTEM PROCESS 8 102 1.211e-09 3.671e-08
155 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 8 103 1.31e-09 3.931e-08
156 POSITIVE REGULATION OF PROTEIN IMPORT 8 104 1.415e-09 4.221e-08
157 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 6 36 1.526e-09 4.522e-08
158 CELLULAR RESPONSE TO HORMONE STIMULUS 14 552 1.702e-09 5.012e-08
159 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 10 218 1.745e-09 5.108e-08
160 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 10 220 1.907e-09 5.545e-08
161 CELLULAR RESPONSE TO GLUCAGON STIMULUS 6 38 2.152e-09 6.219e-08
162 LYMPHOCYTE APOPTOTIC PROCESS 5 18 2.374e-09 6.818e-08
163 REGULATION OF MEMBRANE PERMEABILITY 7 70 2.508e-09 7.159e-08
164 RESPONSE TO AMINO ACID 8 112 2.561e-09 7.222e-08
165 REGULATION OF ORGANELLE ORGANIZATION 19 1178 2.559e-09 7.222e-08
166 RESPONSE TO CARBOHYDRATE 9 168 3.113e-09 8.725e-08
167 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 7 74 3.727e-09 1.039e-07
168 NEGATIVE REGULATION OF MOLECULAR FUNCTION 18 1079 4.419e-09 1.224e-07
169 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 6 43 4.693e-09 1.285e-07
170 CELLULAR COMPONENT DISASSEMBLY INVOLVED IN EXECUTION PHASE OF APOPTOSIS 6 43 4.693e-09 1.285e-07
171 REGULATION OF MAP KINASE ACTIVITY 11 319 5.015e-09 1.357e-07
172 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 12 404 4.996e-09 1.357e-07
173 NECROPTOTIC PROCESS 5 21 5.596e-09 1.505e-07
174 INOSITOL LIPID MEDIATED SIGNALING 8 124 5.754e-09 1.539e-07
175 REGULATION OF PROTEIN IMPORT 9 183 6.593e-09 1.753e-07
176 REGULATION OF NEURON DEATH 10 252 7.035e-09 1.86e-07
177 LEUKOCYTE APOPTOTIC PROCESS 5 23 9.209e-09 2.421e-07
178 RESPONSE TO GLUCAGON 6 48 9.33e-09 2.439e-07
179 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 9 193 1.049e-08 2.727e-07
180 RESPONSE TO OXIDATIVE STRESS 11 352 1.388e-08 3.589e-07
181 MULTICELLULAR ORGANISMAL HOMEOSTASIS 10 272 1.457e-08 3.744e-07
182 NEGATIVE REGULATION OF CATABOLIC PROCESS 9 203 1.628e-08 4.161e-07
183 REGULATION OF MAPK CASCADE 14 660 1.649e-08 4.194e-07
184 MITOCHONDRIAL MEMBRANE ORGANIZATION 7 92 1.735e-08 4.387e-07
185 REGULATION OF TRANSPORT 22 1804 1.767e-08 4.444e-07
186 REGULATION OF NECROTIC CELL DEATH 5 26 1.787e-08 4.47e-07
187 POSITIVE REGULATION OF MAP KINASE ACTIVITY 9 207 1.928e-08 4.797e-07
188 GLYCEROLIPID BIOSYNTHETIC PROCESS 9 211 2.275e-08 5.631e-07
189 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 12 465 2.379e-08 5.826e-07
190 CELL ACTIVATION 13 568 2.377e-08 5.826e-07
191 NECROTIC CELL DEATH 5 28 2.657e-08 6.472e-07
192 POSITIVE REGULATION OF MAPK CASCADE 12 470 2.676e-08 6.485e-07
193 LIPID PHOSPHORYLATION 7 99 2.897e-08 6.984e-07
194 REGULATION OF MITOCHONDRION ORGANIZATION 9 218 3.016e-08 7.197e-07
195 MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS 6 58 3.002e-08 7.197e-07
196 REGULATION OF NECROPTOTIC PROCESS 4 11 3.094e-08 7.307e-07
197 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 4 11 3.094e-08 7.307e-07
198 RESPONSE TO INORGANIC SUBSTANCE 12 479 3.296e-08 7.746e-07
199 DEFENSE RESPONSE 18 1231 3.406e-08 7.963e-07
200 POSITIVE REGULATION OF GENE EXPRESSION 21 1733 4.685e-08 1.09e-06
201 CELLULAR RESPONSE TO BIOTIC STIMULUS 8 163 4.922e-08 1.139e-06
202 PHOSPHOLIPID BIOSYNTHETIC PROCESS 9 235 5.753e-08 1.325e-06
203 REGULATION OF CELLULAR LOCALIZATION 18 1277 5.958e-08 1.366e-06
204 REGULATION OF BODY FLUID LEVELS 12 506 6.003e-08 1.369e-06
205 RESPONSE TO ACID CHEMICAL 10 319 6.544e-08 1.485e-06
206 HEPATOCYTE APOPTOTIC PROCESS 4 13 6.671e-08 1.499e-06
207 INTERLEUKIN 1 MEDIATED SIGNALING PATHWAY 4 13 6.671e-08 1.499e-06
208 T CELL HOMEOSTASIS 5 34 7.412e-08 1.658e-06
209 REGULATION OF CAMP DEPENDENT PROTEIN KINASE ACTIVITY 4 14 9.316e-08 2.074e-06
210 WATER HOMEOSTASIS 6 70 9.438e-08 2.091e-06
211 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 6 71 1.028e-07 2.268e-06
212 LEUKOCYTE CELL CELL ADHESION 9 255 1.156e-07 2.537e-06
213 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 9 258 1.277e-07 2.789e-06
214 LEUKOCYTE MIGRATION 9 259 1.319e-07 2.868e-06
215 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 126 1.536e-07 3.324e-06
216 RESPONSE TO REACTIVE OXYGEN SPECIES 8 191 1.674e-07 3.606e-06
217 CELLULAR HOMEOSTASIS 13 676 1.799e-07 3.857e-06
218 CELLULAR CHEMICAL HOMEOSTASIS 12 570 2.176e-07 4.644e-06
219 REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 4 17 2.199e-07 4.673e-06
220 JNK CASCADE 6 82 2.446e-07 5.174e-06
221 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 9 282 2.71e-07 5.653e-06
222 REGULATION OF LIPID METABOLIC PROCESS 9 282 2.71e-07 5.653e-06
223 RESPONSE TO ALKALOID 7 137 2.722e-07 5.653e-06
224 ACTIVATION OF MAPK ACTIVITY 7 137 2.722e-07 5.653e-06
225 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 14 829 2.753e-07 5.692e-06
226 REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 5 44 2.822e-07 5.811e-06
227 REGULATION OF CYTOPLASMIC TRANSPORT 11 481 3.272e-07 6.706e-06
228 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 10 381 3.393e-07 6.894e-06
229 MITOCHONDRION ORGANIZATION 12 594 3.382e-07 6.894e-06
230 REGULATION OF CELL ACTIVATION 11 484 3.48e-07 7.04e-06
231 LEUKOCYTE DIFFERENTIATION 9 292 3.634e-07 7.319e-06
232 CELLULAR RESPONSE TO INTERLEUKIN 1 6 88 3.73e-07 7.481e-06
233 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 9 297 4.19e-07 8.367e-06
234 RESPONSE TO TEMPERATURE STIMULUS 7 148 4.6e-07 9.115e-06
235 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 15 1004 4.603e-07 9.115e-06
236 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 20 1805 4.655e-07 9.177e-06
237 LYMPHOCYTE HOMEOSTASIS 5 50 5.426e-07 1.065e-05
238 NEGATIVE REGULATION OF LIPID CATABOLIC PROCESS 4 21 5.477e-07 1.071e-05
239 REGULATION OF PROTEIN TARGETING 9 307 5.528e-07 1.076e-05
240 RESPONSE TO NICOTINE 5 51 6.001e-07 1.163e-05
241 REGULATION OF CELL ADHESION 12 629 6.209e-07 1.199e-05
242 RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 4 22 6.679e-07 1.284e-05
243 REGULATION OF GLUCOSE TRANSPORT 6 100 7.963e-07 1.525e-05
244 REGULATION OF EXECUTION PHASE OF APOPTOSIS 4 24 9.655e-07 1.841e-05
245 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 7 167 1.039e-06 1.973e-05
246 APOPTOTIC MITOCHONDRIAL CHANGES 5 57 1.054e-06 1.993e-05
247 RESPONSE TO METAL ION 9 333 1.087e-06 2.048e-05
248 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 6 106 1.123e-06 2.106e-05
249 EPITHELIAL CELL APOPTOTIC PROCESS 4 25 1.147e-06 2.143e-05
250 REGULATION OF AUTOPHAGY 8 249 1.251e-06 2.322e-05
251 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 15 1087 1.253e-06 2.322e-05
252 NEGATIVE REGULATION OF KINASE ACTIVITY 8 250 1.289e-06 2.381e-05
253 REGULATION OF GLUCOSE IMPORT 5 60 1.365e-06 2.49e-05
254 LYMPHOCYTE ACTIVATION 9 342 1.355e-06 2.49e-05
255 LEUKOCYTE HOMEOSTASIS 5 60 1.365e-06 2.49e-05
256 RESPONSE TO CORTICOSTEROID 7 176 1.476e-06 2.684e-05
257 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 12 684 1.496e-06 2.709e-05
258 MITOCHONDRIAL TRANSPORT 7 177 1.533e-06 2.766e-05
259 DNA CATABOLIC PROCESS 4 27 1.583e-06 2.844e-05
260 CELLULAR RESPONSE TO LIPID 10 457 1.767e-06 3.162e-05
261 RESPONSE TO INTERLEUKIN 1 6 115 1.811e-06 3.228e-05
262 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 11 573 1.821e-06 3.234e-05
263 SINGLE ORGANISM CELL ADHESION 10 459 1.837e-06 3.251e-05
264 GLYCEROLIPID METABOLIC PROCESS 9 356 1.885e-06 3.323e-05
265 POSITIVE REGULATION OF NIK NF KAPPAB SIGNALING 4 29 2.132e-06 3.744e-05
266 RESPONSE TO ALCOHOL 9 362 2.163e-06 3.783e-05
267 PHOSPHOLIPID METABOLIC PROCESS 9 364 2.263e-06 3.943e-05
268 POSITIVE REGULATION OF NEURON DEATH 5 67 2.372e-06 4.118e-05
269 REGULATION OF NEURON APOPTOTIC PROCESS 7 192 2.635e-06 4.558e-05
270 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 9 372 2.703e-06 4.658e-05
271 MYD88 DEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 4 32 3.205e-06 5.48e-05
272 REGULATION OF CELL CELL ADHESION 9 380 3.215e-06 5.48e-05
273 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 4 32 3.205e-06 5.48e-05
274 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION 6 128 3.379e-06 5.739e-05
275 PROTEIN KINASE B SIGNALING 4 34 4.114e-06 6.936e-05
276 CELLULAR RESPONSE TO ALKALOID 4 34 4.114e-06 6.936e-05
277 REGULATION OF INFLAMMATORY RESPONSE 8 294 4.298e-06 7.22e-05
278 LIPID MODIFICATION 7 210 4.763e-06 7.972e-05
279 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 6 138 5.222e-06 8.709e-05
280 NEGATIVE REGULATION OF LIPID METABOLIC PROCESS 5 80 5.719e-06 9.469e-05
281 INSULIN RECEPTOR SIGNALING PATHWAY 5 80 5.719e-06 9.469e-05
282 REGULATION OF HOMOTYPIC CELL CELL ADHESION 8 307 5.905e-06 9.744e-05
283 RESPONSE TO ESTROGEN 7 218 6.088e-06 0.0001001
284 PLATELET ACTIVATION 6 142 6.157e-06 0.0001009
285 CELLULAR RESPONSE TO OXYGEN LEVELS 6 143 6.411e-06 0.0001047
286 LEUKOCYTE ACTIVATION 9 414 6.438e-06 0.0001047
287 REGULATION OF PROTEIN MATURATION 5 82 6.459e-06 0.0001047
288 REGULATION OF VITAMIN METABOLIC PROCESS 3 12 6.735e-06 0.0001084
289 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 3 12 6.735e-06 0.0001084
290 REGULATION OF HEMOPOIESIS 8 314 6.964e-06 0.0001117
291 RESPONSE TO ESTRADIOL 6 146 7.223e-06 0.0001155
292 PEPTIDYL SERINE MODIFICATION 6 148 7.81e-06 0.000124
293 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 18 1784 7.8e-06 0.000124
294 REGULATION OF CELL CYCLE 13 949 7.869e-06 0.0001245
295 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 40 7.991e-06 0.000126
296 RESPONSE TO COBALT ION 3 13 8.736e-06 0.0001373
297 RESPONSE TO DRUG 9 431 8.894e-06 0.0001393
298 REGULATION OF LEUKOCYTE DIFFERENTIATION 7 232 9.143e-06 0.0001418
299 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 6 152 9.099e-06 0.0001418
300 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 5 88 9.138e-06 0.0001418
301 RESPONSE TO HEAT 5 89 9.658e-06 0.0001493
302 REGULATION OF NIK NF KAPPAB SIGNALING 4 42 9.74e-06 0.0001496
303 POSITIVE REGULATION OF GLUCOSE TRANSPORT 4 42 9.74e-06 0.0001496
304 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 9 437 9.934e-06 0.0001521
305 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 6 156 1.056e-05 0.000161
306 TOLL LIKE RECEPTOR 9 SIGNALING PATHWAY 3 14 1.109e-05 0.0001687
307 REGULATION OF CYTOKINE PRODUCTION 10 563 1.114e-05 0.0001688
308 RESPONSE TO TOXIC SUBSTANCE 7 241 1.171e-05 0.0001769
309 POSITIVE REGULATION OF CELL CELL ADHESION 7 243 1.235e-05 0.000186
310 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 9 450 1.255e-05 0.0001884
311 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 14 1152 1.302e-05 0.0001948
312 RESPONSE TO VIRUS 7 247 1.373e-05 0.0002048
313 APOPTOTIC DNA FRAGMENTATION 3 15 1.383e-05 0.0002057
314 IMMUNE SYSTEM DEVELOPMENT 10 582 1.484e-05 0.00022
315 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 4 47 1.534e-05 0.0002265
316 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 8 351 1.563e-05 0.0002294
317 CELLULAR PROCESS INVOLVED IN REPRODUCTION IN MULTICELLULAR ORGANISM 7 252 1.563e-05 0.0002294
318 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 11 720 1.592e-05 0.0002329
319 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 6 168 1.61e-05 0.0002348
320 REGULATION OF LIPID KINASE ACTIVITY 4 48 1.669e-05 0.0002427
321 GAMETE GENERATION 10 595 1.795e-05 0.0002603
322 STRIATED MUSCLE CELL DIFFERENTIATION 6 173 1.9e-05 0.0002746
323 RESPONSE TO GAMMA RADIATION 4 50 1.966e-05 0.0002832
324 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 10 602 1.985e-05 0.0002851
325 CELLULAR RESPONSE TO ACID CHEMICAL 6 175 2.028e-05 0.0002904
326 ACTIVATION OF NF KAPPAB INDUCING KINASE ACTIVITY 3 17 2.058e-05 0.000292
327 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 3 17 2.058e-05 0.000292
328 NEGATIVE REGULATION OF ANOIKIS 3 17 2.058e-05 0.000292
329 AGING 7 264 2.109e-05 0.0002982
330 CELL CELL ADHESION 10 608 2.161e-05 0.0003047
331 EMBRYO DEVELOPMENT 12 894 2.269e-05 0.000319
332 POSITIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 4 52 2.3e-05 0.0003214
333 REGULATION OF LIPID CATABOLIC PROCESS 4 52 2.3e-05 0.0003214
334 IMMUNE EFFECTOR PROCESS 9 486 2.307e-05 0.0003214
335 INOSITOL PHOSPHATE MEDIATED SIGNALING 3 18 2.464e-05 0.0003423
336 CELLULAR RESPONSE TO AMINO ACID STIMULUS 4 53 2.482e-05 0.0003427
337 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 4 53 2.482e-05 0.0003427
338 RESPONSE TO KETONE 6 182 2.53e-05 0.0003484
339 RESPONSE TO HYDROGEN PEROXIDE 5 109 2.588e-05 0.0003552
340 REGULATION OF MYELOID CELL DIFFERENTIATION 6 183 2.61e-05 0.0003572
341 RESPONSE TO STEROID HORMONE 9 497 2.75e-05 0.0003752
342 MULTICELLULAR ORGANISM REPRODUCTION 11 768 2.888e-05 0.0003929
343 NEGATIVE REGULATION OF MEIOTIC CELL CYCLE 3 19 2.92e-05 0.0003949
344 DNA CATABOLIC PROCESS ENDONUCLEOLYTIC 3 19 2.92e-05 0.0003949
345 PROTEIN DEPHOSPHORYLATION 6 190 3.223e-05 0.0004346
346 PROTEIN AUTOPHOSPHORYLATION 6 192 3.417e-05 0.0004596
347 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 59 3.803e-05 0.0005099
348 REGULATION OF MONOOXYGENASE ACTIVITY 4 60 4.064e-05 0.0005434
349 REGULATION OF B CELL ACTIVATION 5 121 4.276e-05 0.0005701
350 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 4 61 4.339e-05 0.0005769
351 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 12 957 4.419e-05 0.0005858
352 REPRODUCTION 14 1297 4.85e-05 0.0006411
353 POSITIVE REGULATION OF CELL PROLIFERATION 11 814 4.905e-05 0.0006465
354 REGULATION OF RESPONSE TO WOUNDING 8 413 4.976e-05 0.0006522
355 RESPONSE TO RADIATION 8 413 4.976e-05 0.0006522
356 PROTEIN COMPLEX BIOGENESIS 13 1132 5.04e-05 0.0006561
357 CELL PROLIFERATION 10 672 5.048e-05 0.0006561
358 PROTEIN COMPLEX ASSEMBLY 13 1132 5.04e-05 0.0006561
359 LIPID BIOSYNTHETIC PROCESS 9 539 5.167e-05 0.0006697
360 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 3 23 5.287e-05 0.0006834
361 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 9 541 5.317e-05 0.0006834
362 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 9 541 5.317e-05 0.0006834
363 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 16 1672 5.43e-05 0.0006961
364 LYMPHOCYTE DIFFERENTIATION 6 209 5.486e-05 0.0007012
365 ESTABLISHMENT OF LOCALIZATION IN CELL 16 1676 5.589e-05 0.0007122
366 REGULATION OF CELL DIFFERENTIATION 15 1492 5.602e-05 0.0007122
367 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 12 983 5.727e-05 0.0007261
368 NEGATIVE REGULATION OF PHOSPHORYLATION 8 422 5.789e-05 0.000732
369 NUCLEAR IMPORT 5 129 5.805e-05 0.000732
370 POSITIVE REGULATION OF CELL ACTIVATION 7 311 5.976e-05 0.0007515
371 REGULATION OF ANOIKIS 3 24 6.029e-05 0.0007561
372 POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 5 131 6.246e-05 0.0007813
373 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 9 554 6.383e-05 0.0007962
374 B CELL ACTIVATION 5 132 6.476e-05 0.0008057
375 NEGATIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 4 68 6.659e-05 0.0008262
376 CELLULAR EXTRAVASATION 3 25 6.835e-05 0.0008436
377 APOPTOTIC NUCLEAR CHANGES 3 25 6.835e-05 0.0008436
378 PROTEIN OLIGOMERIZATION 8 434 7.044e-05 0.000867
379 DEVELOPMENTAL PROGRAMMED CELL DEATH 3 26 7.709e-05 0.0009465
380 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 74 9.274e-05 0.001136
381 POSITIVE REGULATION OF ACUTE INFLAMMATORY RESPONSE 3 28 9.669e-05 0.001175
382 POSITIVE REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 3 28 9.669e-05 0.001175
383 MODULATION BY SYMBIONT OF HOST CELLULAR PROCESS 3 28 9.669e-05 0.001175
384 GRANULOCYTE MIGRATION 4 75 9.773e-05 0.001184
385 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 6 233 9.997e-05 0.001208
386 SEXUAL REPRODUCTION 10 730 0.0001005 0.001211
387 RESPONSE TO IONIZING RADIATION 5 145 0.000101 0.001212
388 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 5 145 0.000101 0.001212
389 ORGANOPHOSPHATE METABOLIC PROCESS 11 885 0.0001037 0.001241
390 CELLULAR RESPONSE TO INSULIN STIMULUS 5 146 0.0001044 0.001245
391 PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 3 29 0.0001076 0.001274
392 MUSCLE ADAPTATION 3 29 0.0001076 0.001274
393 POSITIVE REGULATION OF MONOOXYGENASE ACTIVITY 3 29 0.0001076 0.001274
394 MUSCLE CELL DIFFERENTIATION 6 237 0.0001097 0.001296
395 LYMPHOCYTE COSTIMULATION 4 78 0.0001139 0.001341
396 SYSTEM PROCESS 16 1785 0.0001182 0.001389
397 NEGATIVE REGULATION OF B CELL ACTIVATION 3 30 0.0001193 0.001398
398 RESPONSE TO GROWTH FACTOR 8 475 0.0001316 0.001539
399 CELL DEVELOPMENT 14 1426 0.0001342 0.001565
400 CELLULAR LIPID METABOLIC PROCESS 11 913 0.0001365 0.001588
401 PROTEIN IMPORT 5 155 0.0001382 0.001604
402 PROTEIN LOCALIZATION TO NUCLEUS 5 156 0.0001425 0.001649
403 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 9 616 0.0001429 0.00165
404 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE 7 361 0.0001512 0.001741
405 REGULATION OF JNK CASCADE 5 159 0.0001557 0.001789
406 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 4 86 0.0001663 0.001906
407 REGULATION OF PEPTIDE TRANSPORT 6 256 0.0001671 0.00191
408 POSITIVE REGULATION OF HEMOPOIESIS 5 163 0.0001749 0.001995
409 POSITIVE REGULATION OF CYTOKINE PRODUCTION 7 370 0.0001759 0.002001
410 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 4 88 0.0001818 0.002063
411 NEGATIVE REGULATION OF PROTEIN PROCESSING 3 35 0.0001901 0.002147
412 NEGATIVE REGULATION OF PROTEIN MATURATION 3 35 0.0001901 0.002147
413 POSITIVE REGULATION OF CELL ADHESION 7 376 0.0001941 0.002187
414 REGULATION OF OXIDOREDUCTASE ACTIVITY 4 90 0.0001982 0.002222
415 CALCIUM MEDIATED SIGNALING 4 90 0.0001982 0.002222
416 NEGATIVE REGULATION OF PROTEIN COMPLEX DISASSEMBLY 5 170 0.0002127 0.002379
417 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 10 801 0.0002141 0.002389
418 NEGATIVE REGULATION OF NEURON DEATH 5 171 0.0002186 0.002433
419 MODULATION BY VIRUS OF HOST MORPHOLOGY OR PHYSIOLOGY 3 37 0.0002247 0.002495
420 CELLULAR COMPONENT DISASSEMBLY 8 515 0.0002284 0.00253
421 NEGATIVE REGULATION OF ORGANELLE ORGANIZATION 7 387 0.0002314 0.002558
422 REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 4 94 0.0002343 0.002584
423 FC GAMMA RECEPTOR SIGNALING PATHWAY 4 95 0.000244 0.002672
424 HOMEOSTASIS OF NUMBER OF CELLS 5 175 0.0002433 0.002672
425 REGULATION OF LIPID TRANSPORT 4 95 0.000244 0.002672
426 MYELOID LEUKOCYTE DIFFERENTIATION 4 96 0.000254 0.002768
427 FEMALE GAMETE GENERATION 4 96 0.000254 0.002768
428 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 3 39 0.0002631 0.002853
429 ERBB2 SIGNALING PATHWAY 3 39 0.0002631 0.002853
430 PROTEIN COMPLEX SUBUNIT ORGANIZATION 14 1527 0.0002742 0.002967
431 REGULATION OF MEIOTIC CELL CYCLE 3 40 0.0002837 0.003063
432 MYELOID LEUKOCYTE MIGRATION 4 99 0.0002858 0.003078
433 REGULATION OF LIPID STORAGE 3 41 0.0003054 0.00326
434 MITOTIC SPINDLE ASSEMBLY 3 41 0.0003054 0.00326
435 MICROTUBULE CYTOSKELETON ORGANIZATION INVOLVED IN MITOSIS 3 41 0.0003054 0.00326
436 DEPHOSPHORYLATION 6 286 0.0003034 0.00326
437 REGULATION OF CELLULAR RESPONSE TO STRESS 9 691 0.0003353 0.00357
438 MYELOID CELL DIFFERENTIATION 5 189 0.0003469 0.003686
439 MYELOID LEUKOCYTE MEDIATED IMMUNITY 3 43 0.000352 0.003731
440 REGULATION OF CELL CYCLE PROCESS 8 558 0.0003912 0.004137
441 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 4 108 0.0003982 0.004202
442 POSITIVE REGULATION OF INTERLEUKIN 8 PRODUCTION 3 45 0.0004029 0.004218
443 MODIFICATION BY SYMBIONT OF HOST MORPHOLOGY OR PHYSIOLOGY 3 45 0.0004029 0.004218
444 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 13 1395 0.0004034 0.004218
445 REGULATION OF ALCOHOL BIOSYNTHETIC PROCESS 3 45 0.0004029 0.004218
446 MACROMOLECULAR COMPLEX ASSEMBLY 13 1398 0.0004118 0.004296
447 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 197 0.0004195 0.004366
448 PEPTIDYL THREONINE MODIFICATION 3 46 0.00043 0.004466
449 NEGATIVE REGULATION OF CELL CYCLE 7 433 0.0004555 0.004721
450 POSITIVE REGULATION OF OXIDOREDUCTASE ACTIVITY 3 47 0.0004583 0.004728
451 RESPONSE TO ANTIBIOTIC 3 47 0.0004583 0.004728
452 PROTEIN HETEROOLIGOMERIZATION 4 113 0.0004728 0.004867
453 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 3 48 0.0004877 0.004988
454 REGULATION OF NF KAPPAB IMPORT INTO NUCLEUS 3 48 0.0004877 0.004988
455 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 3 48 0.0004877 0.004988
456 MULTI ORGANISM REPRODUCTIVE PROCESS 10 891 0.0004985 0.005087
457 RESPONSE TO INSULIN 5 205 0.0005029 0.005121
458 REGULATION OF LEUKOCYTE PROLIFERATION 5 206 0.0005142 0.005224
459 REGULATION OF TOLL LIKE RECEPTOR SIGNALING PATHWAY 3 49 0.0005184 0.005243
460 REGULATION OF STEROID BIOSYNTHETIC PROCESS 3 49 0.0005184 0.005243
461 SINGLE ORGANISM CELLULAR LOCALIZATION 10 898 0.0005299 0.005349
462 REGULATION OF FEVER GENERATION 2 11 0.0005442 0.005469
463 NEGATIVE REGULATION OF NECROTIC CELL DEATH 2 11 0.0005442 0.005469
464 REGULATION OF HOMEOSTATIC PROCESS 7 447 0.0005505 0.005473
465 NEGATIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 5 209 0.0005491 0.005473
466 REGULATION OF PEPTIDE SECRETION 5 209 0.0005491 0.005473
467 GERM CELL DEVELOPMENT 5 209 0.0005491 0.005473
468 POSITIVE REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 3 50 0.0005502 0.005473
469 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 4 118 0.0005568 0.005524
470 POSITIVE REGULATION OF PROTEIN SECRETION 5 211 0.0005733 0.005676
471 GLUCOSE METABOLIC PROCESS 4 119 0.0005748 0.005678
472 NEGATIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 3 51 0.0005832 0.00575
473 CYTOKINE PRODUCTION 4 120 0.0005932 0.005835
474 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 4 122 0.0006312 0.006197
475 NEGATIVE REGULATION OF PROTEOLYSIS 6 329 0.0006364 0.006218
476 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 5 216 0.0006374 0.006218
477 NEGATIVE REGULATION OF TRANSPORT 7 458 0.0006356 0.006218
478 REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS 3 53 0.0006531 0.006266
479 REGULATION OF ENDOTHELIAL CELL DEVELOPMENT 2 12 0.0006517 0.006266
480 NEGATIVE REGULATION OF AUTOPHAGY 3 53 0.0006531 0.006266
481 REGULATION OF CHEMOKINE BIOSYNTHETIC PROCESS 2 12 0.0006517 0.006266
482 REGULATION OF ESTABLISHMENT OF ENDOTHELIAL BARRIER 2 12 0.0006517 0.006266
483 REGULATION OF PROTEIN COMPLEX DISASSEMBLY 5 217 0.0006509 0.006266
484 T CELL DIFFERENTIATION 4 123 0.0006509 0.006266
485 POSITIVE REGULATION OF INTERLEUKIN 2 BIOSYNTHETIC PROCESS 2 12 0.0006517 0.006266
486 MACROMOLECULE CATABOLIC PROCESS 10 926 0.0006726 0.00644
487 NEGATIVE REGULATION OF REPRODUCTIVE PROCESS 3 54 0.00069 0.006579
488 REGULATION OF MITOCHONDRIAL MEMBRANE POTENTIAL 3 54 0.00069 0.006579
489 RESPONSE TO UV 4 126 0.0007125 0.00678
490 REGULATION OF MITOTIC CELL CYCLE 7 468 0.0007218 0.006855
491 REGULATION OF B CELL PROLIFERATION 3 55 0.0007281 0.0069
492 REGULATION OF LIPID BIOSYNTHETIC PROCESS 4 128 0.0007558 0.007133
493 REGULATION OF DNA METABOLIC PROCESS 6 340 0.0007556 0.007133
494 POSITIVE REGULATION OF STEROID BIOSYNTHETIC PROCESS 2 13 0.0007686 0.007181
495 REGULATION OF HISTONE PHOSPHORYLATION 2 13 0.0007686 0.007181
496 REGULATION OF PROTEIN POLYUBIQUITINATION 2 13 0.0007686 0.007181
497 POSITIVE REGULATION OF MACROPHAGE DIFFERENTIATION 2 13 0.0007686 0.007181
498 REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY 2 13 0.0007686 0.007181
499 INNATE IMMUNE RESPONSE 8 619 0.0007738 0.007215
500 POSITIVE REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 3 58 0.0008505 0.007915
501 REGULATION OF FIBROBLAST APOPTOTIC PROCESS 2 14 0.0008949 0.008278
502 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 14 0.0008949 0.008278
503 T CELL MIGRATION 2 14 0.0008949 0.008278
504 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 4 135 0.000922 0.008512
505 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 0.000939 0.008652
506 RESPONSE TO ETHANOL 4 136 0.0009477 0.008697
507 NEGATIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 4 136 0.0009477 0.008697
508 REGULATION OF INTERLEUKIN 8 PRODUCTION 3 61 0.0009853 0.009025
509 MAINTENANCE OF LOCATION 4 138 0.001001 0.009146
510 REGULATION OF HEAT GENERATION 2 15 0.00103 0.009274
511 RESPIRATORY BURST 2 15 0.00103 0.009274
512 LIPID METABOLIC PROCESS 11 1158 0.001025 0.009274
513 NEGATIVE REGULATION OF INTERLEUKIN 12 PRODUCTION 2 15 0.00103 0.009274
514 NEGATIVE REGULATION OF B CELL PROLIFERATION 2 15 0.00103 0.009274
515 CHRONIC INFLAMMATORY RESPONSE 2 15 0.00103 0.009274
516 POSITIVE REGULATION OF MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 2 15 0.00103 0.009274
517 REGULATION OF VIRAL INDUCED CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 2 15 0.00103 0.009274
518 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 7 498 0.001038 0.00932
519 POSITIVE REGULATION OF JUN KINASE ACTIVITY 3 63 0.001082 0.009702
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 22 842 6.222e-15 5.781e-12
2 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 22 992 1.747e-13 8.113e-11
3 ENZYME BINDING 27 1737 6.475e-13 2.005e-10
4 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 43 9.277e-13 2.031e-10
5 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 9 70 1.093e-12 2.031e-10
6 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY BINDING 8 47 1.992e-12 3.084e-10
7 CYTOKINE RECEPTOR BINDING 13 271 2.763e-12 3.668e-10
8 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 8 51 3.993e-12 4.637e-10
9 DEATH RECEPTOR BINDING 6 18 1.521e-11 1.57e-09
10 UBIQUITIN LIKE PROTEIN LIGASE BINDING 12 264 3.894e-11 3.617e-09
11 PROTEIN SERINE THREONINE KINASE ACTIVITY 14 445 1.032e-10 8.719e-09
12 PROTEIN KINASE ACTIVITY 16 640 1.177e-10 9.115e-09
13 KINASE REGULATOR ACTIVITY 10 186 3.723e-10 2.66e-08
14 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC PROCESS 5 15 8.382e-10 5.562e-08
15 PROTEIN HETERODIMERIZATION ACTIVITY 13 468 2.369e-09 1.467e-07
16 MOLECULAR FUNCTION REGULATOR 20 1353 3.888e-09 2.212e-07
17 CYSTEINE TYPE ENDOPEPTIDASE REGULATOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 6 42 4.048e-09 2.212e-07
18 ADENYL NUCLEOTIDE BINDING 21 1514 4.373e-09 2.257e-07
19 ENZYME REGULATOR ACTIVITY 17 959 5.331e-09 2.607e-07
20 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 5 30 3.833e-08 1.781e-06
21 PROTEASE BINDING 7 104 4.082e-08 1.806e-06
22 PROTEIN KINASE A CATALYTIC SUBUNIT BINDING 4 15 1.267e-07 5.352e-06
23 INTERLEUKIN 1 RECEPTOR BINDING 4 16 1.686e-07 6.264e-06
24 RIBONUCLEOTIDE BINDING 21 1860 1.573e-07 6.264e-06
25 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 4 16 1.686e-07 6.264e-06
26 PROTEIN KINASE A BINDING 5 42 2.222e-07 7.938e-06
27 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 6 86 3.252e-07 1.119e-05
28 PROTEIN DIMERIZATION ACTIVITY 16 1149 4.53e-07 1.503e-05
29 CAMP BINDING 4 23 8.065e-07 2.584e-05
30 DEATH RECEPTOR ACTIVITY 4 24 9.655e-07 2.99e-05
31 PROTEIN PHOSPHATASE BINDING 6 120 2.322e-06 6.958e-05
32 TUMOR NECROSIS FACTOR RECEPTOR BINDING 4 30 2.455e-06 7.126e-05
33 RECEPTOR BINDING 17 1476 2.56e-06 7.208e-05
34 KINASE BINDING 11 606 3.124e-06 8.536e-05
35 IDENTICAL PROTEIN BINDING 15 1209 4.655e-06 0.0001236
36 CYCLIC NUCLEOTIDE BINDING 4 36 5.2e-06 0.0001306
37 INSULIN RECEPTOR SUBSTRATE BINDING 3 11 5.063e-06 0.0001306
38 KINASE INHIBITOR ACTIVITY 5 89 9.658e-06 0.0002361
39 PHOSPHATASE BINDING 6 162 1.309e-05 0.0003118
40 CYSTEINE TYPE PEPTIDASE ACTIVITY 6 184 2.691e-05 0.0006098
41 ENZYME INHIBITOR ACTIVITY 8 378 2.658e-05 0.0006098
42 PEPTIDASE ACTIVATOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 3 21 3.989e-05 0.0008823
43 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 4 64 5.245e-05 0.001116
44 CYSTEINE TYPE ENDOPEPTIDASE INHIBITOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 3 23 5.287e-05 0.001116
45 GROWTH FACTOR RECEPTOR BINDING 5 129 5.805e-05 0.001198
46 PEPTIDASE REGULATOR ACTIVITY 6 214 6.254e-05 0.001263
47 PROTEIN DOMAIN SPECIFIC BINDING 9 624 0.0001575 0.003113
48 HEAT SHOCK PROTEIN BINDING 4 89 0.0001899 0.0036
49 CYTOKINE RECEPTOR ACTIVITY 4 89 0.0001899 0.0036
50 PEPTIDASE ACTIVATOR ACTIVITY 3 38 0.0002434 0.004522
51 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 5 178 0.0002632 0.004794
52 SIGNAL TRANSDUCER ACTIVITY 15 1731 0.0002935 0.005243
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 16 237 2.679e-17 1.565e-14
2 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 8 20 8.535e-16 2.492e-13
3 CATALYTIC COMPLEX 24 1038 3.851e-15 7.496e-13
4 MEMBRANE MICRODOMAIN 14 288 3.02e-13 4.409e-11
5 MEMBRANE PROTEIN COMPLEX 20 1020 2.723e-11 3.18e-09
6 CILIARY BASE 6 23 8.168e-11 7.95e-09
7 TRANSFERASE COMPLEX 16 703 4.647e-10 3.393e-08
8 PROTEIN KINASE COMPLEX 8 90 4.41e-10 3.393e-08
9 EXTRINSIC COMPONENT OF MEMBRANE 8 252 1.369e-06 8.881e-05
10 PLASMA MEMBRANE PROTEIN COMPLEX 10 510 4.689e-06 0.0002738
11 CYTOSOLIC PART 7 223 7.062e-06 0.0003749
12 MEMBRANE REGION 14 1134 1.089e-05 0.0005302
13 PHOSPHATASE COMPLEX 4 48 1.669e-05 0.0007498
14 CILIARY PART 7 307 5.508e-05 0.002298
15 MICROTUBULE CYTOSKELETON 12 1068 0.0001262 0.004913
16 MITOCHONDRION 15 1633 0.000155 0.005657
17 PLASMA MEMBRANE RAFT 4 86 0.0001663 0.005713

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04210_Apoptosis 64 89 6.382e-165 1.13e-162
2 hsa04380_Osteoclast_differentiation 22 128 5.264e-33 4.659e-31
3 hsa04660_T_cell_receptor_signaling_pathway 21 108 1.041e-32 6.14e-31
4 hsa04650_Natural_killer_cell_mediated_cytotoxicity 22 136 2.215e-32 9.801e-31
5 hsa04662_B_cell_receptor_signaling_pathway 19 75 5.191e-32 1.838e-30
6 hsa04620_Toll.like_receptor_signaling_pathway 20 102 3.215e-31 9.485e-30
7 hsa04722_Neurotrophin_signaling_pathway 19 127 3.026e-27 7.651e-26
8 hsa04370_VEGF_signaling_pathway 16 76 1.483e-25 3.282e-24
9 hsa04910_Insulin_signaling_pathway 17 138 6.915e-23 1.36e-21
10 hsa04010_MAPK_signaling_pathway 20 268 1.977e-22 3.499e-21
11 hsa04062_Chemokine_signaling_pathway 16 189 6.985e-19 1.124e-17
12 hsa04510_Focal_adhesion 16 200 1.747e-18 2.578e-17
13 hsa04914_Progesterone.mediated_oocyte_maturation 12 87 5.706e-17 7.768e-16
14 hsa04973_Carbohydrate_digestion_and_absorption 10 44 1.228e-16 1.552e-15
15 hsa04150_mTOR_signaling_pathway 10 52 7.676e-16 9.057e-15
16 hsa04664_Fc_epsilon_RI_signaling_pathway 11 79 1.113e-15 1.231e-14
17 hsa04630_Jak.STAT_signaling_pathway 13 155 2.041e-15 2.125e-14
18 hsa04621_NOD.like_receptor_signaling_pathway 10 59 2.996e-15 2.946e-14
19 hsa04012_ErbB_signaling_pathway 11 87 3.382e-15 3.151e-14
20 hsa04666_Fc_gamma_R.mediated_phagocytosis 10 95 4.41e-13 3.903e-12
21 hsa04960_Aldosterone.regulated_sodium_reabsorption 8 42 7.57e-13 6.38e-12
22 hsa04115_p53_signaling_pathway 8 69 5.013e-11 4.033e-10
23 hsa04622_RIG.I.like_receptor_signaling_pathway 8 71 6.347e-11 4.885e-10
24 hsa04070_Phosphatidylinositol_signaling_system 8 78 1.375e-10 1.014e-09
25 hsa04920_Adipocytokine_signaling_pathway 7 68 2.038e-09 1.443e-08
26 hsa04720_Long.term_potentiation 7 70 2.508e-09 1.707e-08
27 hsa04670_Leukocyte_transendothelial_migration 8 117 3.627e-09 2.378e-08
28 hsa04623_Cytosolic_DNA.sensing_pathway 6 56 2.42e-08 1.53e-07
29 hsa04114_Oocyte_meiosis 7 114 7.712e-08 4.707e-07
30 hsa04810_Regulation_of_actin_cytoskeleton 8 214 3.989e-07 2.354e-06
31 hsa04310_Wnt_signaling_pathway 7 151 5.27e-07 3.009e-06
32 hsa04020_Calcium_signaling_pathway 7 177 1.533e-06 8.482e-06
33 hsa04640_Hematopoietic_cell_lineage 5 88 9.138e-06 4.901e-05
34 hsa00562_Inositol_phosphate_metabolism 4 57 3.316e-05 0.0001726
35 hsa04360_Axon_guidance 5 130 6.023e-05 0.0003046
36 hsa04962_Vasopressin.regulated_water_reabsorption 2 44 0.008746 0.043
37 hsa04120_Ubiquitin_mediated_proteolysis 3 139 0.01005 0.04807
38 hsa04742_Taste_transduction 2 52 0.01206 0.05617
39 hsa04340_Hedgehog_signaling_pathway 2 56 0.01389 0.06305
40 hsa04976_Bile_secretion 2 71 0.02174 0.0962
41 hsa04971_Gastric_acid_secretion 2 74 0.02349 0.1014
42 hsa04970_Salivary_secretion 2 89 0.03303 0.1388
43 hsa04540_Gap_junction 2 90 0.03371 0.1388
44 hsa04912_GnRH_signaling_pathway 2 101 0.04157 0.1635
45 hsa04916_Melanogenesis 2 101 0.04157 0.1635
46 hsa04270_Vascular_smooth_muscle_contraction 2 116 0.05327 0.205
47 hsa04530_Tight_junction 2 133 0.06775 0.2551
48 hsa04141_Protein_processing_in_endoplasmic_reticulum 2 168 0.101 0.3723
49 hsa04740_Olfactory_transduction 2 388 0.3533 1

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

CECR7

hsa-miR-130b-5p;hsa-miR-17-3p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-197-3p;hsa-miR-215-5p;hsa-miR-24-3p;hsa-miR-26b-5p;hsa-miR-335-3p;hsa-miR-361-5p;hsa-miR-491-5p;hsa-miR-590-3p 12 IL1R1 Sponge network 0.551 0.56177 0.097 0.93138 0.556
2

EMX2OS

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-1275;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-424-5p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-502-5p;hsa-miR-505-3p;hsa-miR-548o-3p;hsa-miR-577;hsa-miR-663b;hsa-miR-93-5p 27 AKT3 Sponge network 1.057 0.31716 0.457 0.53933 0.542
3

EMX2OS

hsa-miR-130b-5p;hsa-miR-17-3p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-197-3p;hsa-miR-215-5p;hsa-miR-24-3p;hsa-miR-26b-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-3p;hsa-miR-548o-3p;hsa-miR-590-3p 13 IL1R1 Sponge network 1.057 0.31716 0.097 0.93138 0.517
4

CECR7

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1275;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-28-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-320a;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-362-5p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-502-5p;hsa-miR-93-5p 22 AKT3 Sponge network 0.551 0.56177 0.457 0.53933 0.508
5

MIAT

hsa-miR-153-3p;hsa-miR-17-5p;hsa-miR-192-5p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-29a-3p;hsa-miR-33a-5p;hsa-miR-452-5p 10 BCL2 Sponge network -0.118 0.86338 -0.872 0.24496 0.452
6

CECR7

hsa-miR-141-3p;hsa-miR-148b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-200a-3p;hsa-miR-20a-3p;hsa-miR-25-3p;hsa-miR-320a;hsa-miR-335-3p;hsa-miR-33a-5p;hsa-miR-33b-5p;hsa-miR-361-5p;hsa-miR-376a-5p;hsa-miR-429;hsa-miR-582-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p 22 IRAK3 Sponge network 0.551 0.56177 0.129 0.83349 0.45
7

EMX2OS

hsa-miR-141-3p;hsa-miR-148b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-200a-3p;hsa-miR-20a-3p;hsa-miR-224-3p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-324-5p;hsa-miR-335-3p;hsa-miR-33a-5p;hsa-miR-33b-5p;hsa-miR-374a-3p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-452-3p;hsa-miR-505-3p;hsa-miR-577;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-660-5p;hsa-miR-7-1-3p;hsa-miR-92a-3p 27 IRAK3 Sponge network 1.057 0.31716 0.129 0.83349 0.42
8

MEG3

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-320c;hsa-miR-335-3p;hsa-miR-362-5p;hsa-miR-577;hsa-miR-663b;hsa-miR-93-5p 18 AKT3 Sponge network 0.433 0.33816 0.457 0.53933 0.405
9

CECR7

hsa-let-7f-1-3p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-200b-3p;hsa-miR-29b-1-5p;hsa-miR-32-3p;hsa-miR-320a;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-582-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p 16 PIK3CA Sponge network 0.551 0.56177 0.023 0.97942 0.368
10

CECR7

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-186-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-335-3p;hsa-miR-361-5p;hsa-miR-362-3p;hsa-miR-429;hsa-miR-452-5p;hsa-miR-590-3p 11 PRKAR2B Sponge network 0.551 0.56177 -0.108 0.86421 0.346
11

ZNF883

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-320a;hsa-miR-320c;hsa-miR-335-3p;hsa-miR-33a-3p 13 AKT3 Sponge network 0.913 0.16772 0.457 0.53933 0.3
12

EMX2OS

hsa-miR-1296-5p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-200b-3p;hsa-miR-215-5p;hsa-miR-25-3p;hsa-miR-32-3p;hsa-miR-324-3p;hsa-miR-577;hsa-miR-590-3p 13 PRKAR1A Sponge network 1.057 0.31716 0.006 0.99718 0.293
13

MEG3

hsa-miR-141-3p;hsa-miR-148b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-200a-3p;hsa-miR-20a-3p;hsa-miR-25-3p;hsa-miR-335-3p;hsa-miR-429;hsa-miR-577;hsa-miR-590-5p;hsa-miR-7-1-3p 14 IRAK3 Sponge network 0.433 0.33816 0.129 0.83349 0.279
14

EMX2OS

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-186-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-362-3p;hsa-miR-452-5p;hsa-miR-590-3p;hsa-miR-92a-3p 11 PRKAR2B Sponge network 1.057 0.31716 -0.108 0.86421 0.278
15

ZNF883

hsa-miR-130b-5p;hsa-miR-17-3p;hsa-miR-181b-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-197-3p;hsa-miR-215-5p;hsa-miR-26b-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-3p 11 IL1R1 Sponge network 0.913 0.16772 0.097 0.93138 0.277
16

EMX2OS

hsa-let-7f-1-3p;hsa-miR-146a-5p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-200b-3p;hsa-miR-29b-1-5p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-339-5p;hsa-miR-374b-5p;hsa-miR-576-5p;hsa-miR-577;hsa-miR-582-3p;hsa-miR-590-3p;hsa-miR-7-1-3p 19 PIK3CA Sponge network 1.057 0.31716 0.023 0.97942 0.254

Quest ID: 1427dddf56277bcfa297d39e519a5a75