This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | hsa-miR-125a-3p | CIRBP | 1.24 | 1.0E-5 | -0.68 | 0.00013 | miRanda | -0.13 | 2.0E-5 | NA | |
2 | hsa-miR-24-3p | CIRBP | 1 | 0 | -0.68 | 0.00013 | miRNAWalker2 validate | -0.28 | 0 | NA | |
3 | hsa-miR-338-5p | CIRBP | -0.58 | 0.04722 | -0.68 | 0.00013 | MirTarget; PITA; miRNATAP | -0.14 | 0 | NA | |
4 | hsa-miR-590-3p | CIRBP | 2.59 | 0 | -0.68 | 0.00013 | miRanda | -0.14 | 0 | NA | |
5 | hsa-miR-590-5p | CIRBP | 3.18 | 0 | -0.68 | 0.00013 | miRanda | -0.1 | 0.00028 | NA | |
6 | hsa-miR-629-3p | CIRBP | 2.37 | 0 | -0.68 | 0.00013 | mirMAP | -0.17 | 0 | NA |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | RNA PROCESSING | 61 | 835 | 2.575e-33 | 1.198e-29 |
2 | MRNA METABOLIC PROCESS | 53 | 611 | 1.785e-32 | 4.152e-29 |
3 | MRNA PROCESSING | 46 | 432 | 4.887e-32 | 7.579e-29 |
4 | RNA SPLICING VIA TRANSESTERIFICATION REACTIONS | 38 | 267 | 3.236e-31 | 3.765e-28 |
5 | RNA SPLICING | 42 | 367 | 1.6e-30 | 1.489e-27 |
6 | RIBONUCLEOPROTEIN COMPLEX BIOGENESIS | 29 | 440 | 1.009e-14 | 7.826e-12 |
7 | NLS BEARING PROTEIN IMPORT INTO NUCLEUS | 9 | 22 | 8.794e-13 | 5.845e-10 |
8 | MITOTIC CELL CYCLE | 34 | 766 | 3.879e-12 | 2.256e-09 |
9 | CELL CYCLE PHASE TRANSITION | 20 | 255 | 7.54e-12 | 3.509e-09 |
10 | CELL CYCLE | 45 | 1316 | 7.026e-12 | 3.509e-09 |
11 | NUCLEAR IMPORT | 15 | 129 | 1.28e-11 | 5.416e-09 |
12 | REGULATION OF CELL CYCLE | 37 | 949 | 1.751e-11 | 6.788e-09 |
13 | CELL CYCLE G1 S PHASE TRANSITION | 14 | 111 | 2.058e-11 | 6.84e-09 |
14 | G1 S TRANSITION OF MITOTIC CELL CYCLE | 14 | 111 | 2.058e-11 | 6.84e-09 |
15 | CELL CYCLE PROCESS | 39 | 1081 | 4.706e-11 | 1.46e-08 |
16 | POSITIVE REGULATION OF GENE EXPRESSION | 51 | 1733 | 5.365e-11 | 1.56e-08 |
17 | NUCLEAR TRANSPORT | 22 | 355 | 6.696e-11 | 1.833e-08 |
18 | REGULATION OF TELOMERASE RNA LOCALIZATION TO CAJAL BODY | 7 | 15 | 1.058e-10 | 2.59e-08 |
19 | POSITIVE REGULATION OF TELOMERASE RNA LOCALIZATION TO CAJAL BODY | 7 | 15 | 1.058e-10 | 2.59e-08 |
20 | PROTEIN IMPORT | 15 | 155 | 1.811e-10 | 4.214e-08 |
21 | PROTEIN LOCALIZATION TO NUCLEUS | 15 | 156 | 1.985e-10 | 4.398e-08 |
22 | PROTEIN FOLDING | 17 | 224 | 4.965e-10 | 1.05e-07 |
23 | POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION | 23 | 448 | 9.861e-10 | 1.995e-07 |
24 | REGULATION OF MRNA METABOLIC PROCESS | 12 | 118 | 7.121e-09 | 1.381e-06 |
25 | CELL DIVISION | 22 | 460 | 8.502e-09 | 1.582e-06 |
26 | REGULATION OF DNA REPLICATION | 13 | 161 | 2.757e-08 | 4.933e-06 |
27 | RIBONUCLEOPROTEIN COMPLEX SUBUNIT ORGANIZATION | 14 | 199 | 4.588e-08 | 7.907e-06 |
28 | RIBOSOME BIOGENESIS | 17 | 308 | 5.879e-08 | 8.629e-06 |
29 | MULTI ORGANISM TRANSPORT | 9 | 68 | 5.621e-08 | 8.629e-06 |
30 | MULTI ORGANISM LOCALIZATION | 9 | 68 | 5.621e-08 | 8.629e-06 |
31 | POSITIVE REGULATION OF TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING | 7 | 33 | 5.934e-08 | 8.629e-06 |
32 | PROTEIN LOCALIZATION TO ORGANELLE | 23 | 556 | 5.611e-08 | 8.629e-06 |
33 | REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO CHROMOSOME | 5 | 11 | 6.738e-08 | 9.322e-06 |
34 | REGULATION OF TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING | 8 | 50 | 6.811e-08 | 9.322e-06 |
35 | INTERSPECIES INTERACTION BETWEEN ORGANISMS | 25 | 662 | 8.351e-08 | 1.05e-05 |
36 | SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM | 25 | 662 | 8.351e-08 | 1.05e-05 |
37 | DNA METABOLIC PROCESS | 27 | 758 | 8.015e-08 | 1.05e-05 |
38 | MITOTIC NUCLEAR DIVISION | 18 | 361 | 1.101e-07 | 1.314e-05 |
39 | SPLICEOSOMAL COMPLEX ASSEMBLY | 8 | 53 | 1.093e-07 | 1.314e-05 |
40 | RNA LOCALIZATION | 13 | 185 | 1.422e-07 | 1.654e-05 |
41 | RRNA METABOLIC PROCESS | 15 | 255 | 1.595e-07 | 1.81e-05 |
42 | MACROMOLECULAR COMPLEX ASSEMBLY | 38 | 1398 | 1.909e-07 | 2.115e-05 |
43 | REGULATION OF DNA METABOLIC PROCESS | 17 | 340 | 2.417e-07 | 2.616e-05 |
44 | DNA GEOMETRIC CHANGE | 9 | 81 | 2.63e-07 | 2.781e-05 |
45 | REGULATION OF PROTEIN LOCALIZATION TO CHROMOSOME TELOMERIC REGION | 5 | 14 | 2.842e-07 | 2.939e-05 |
46 | CELL CYCLE G2 M PHASE TRANSITION | 11 | 138 | 3.765e-07 | 3.808e-05 |
47 | MACROMOLECULE CATABOLIC PROCESS | 29 | 926 | 3.857e-07 | 3.819e-05 |
48 | REGULATION OF RNA STABILITY | 11 | 139 | 4.049e-07 | 3.846e-05 |
49 | CELLULAR RESPONSE TO DNA DAMAGE STIMULUS | 25 | 720 | 4.05e-07 | 3.846e-05 |
50 | POSITIVE REGULATION OF DNA REPLICATION | 9 | 86 | 4.42e-07 | 4.113e-05 |
51 | RNA SECONDARY STRUCTURE UNWINDING | 7 | 44 | 4.804e-07 | 4.383e-05 |
52 | MODULATION BY SYMBIONT OF HOST CELLULAR PROCESS | 6 | 28 | 5.093e-07 | 4.557e-05 |
53 | ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE | 17 | 361 | 5.597e-07 | 4.914e-05 |
54 | REGULATION OF TELOMERE MAINTENANCE | 8 | 67 | 7.049e-07 | 6.074e-05 |
55 | POSITIVE REGULATION OF TELOMERE MAINTENANCE | 7 | 47 | 7.666e-07 | 6.486e-05 |
56 | POSITIVE REGULATION OF BIOSYNTHETIC PROCESS | 43 | 1805 | 9.815e-07 | 8.155e-05 |
57 | NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS | 31 | 1087 | 1.1e-06 | 8.976e-05 |
58 | REGULATION OF RNA SPLICING | 9 | 97 | 1.237e-06 | 9.927e-05 |
59 | RNA 3 END PROCESSING | 9 | 98 | 1.35e-06 | 0.0001064 |
60 | NCRNA PROCESSING | 17 | 386 | 1.407e-06 | 0.0001091 |
61 | SEXUAL REPRODUCTION | 24 | 730 | 1.831e-06 | 0.0001397 |
62 | REGULATION OF TRANSFERASE ACTIVITY | 28 | 946 | 1.887e-06 | 0.0001416 |
63 | REGULATION OF CELLULAR AMIDE METABOLIC PROCESS | 16 | 354 | 2.075e-06 | 0.0001532 |
64 | CHROMOSOME ORGANIZATION | 29 | 1009 | 2.176e-06 | 0.0001582 |
65 | ORGANELLE FISSION | 19 | 496 | 2.641e-06 | 0.0001862 |
66 | REGULATION OF CHROMOSOME ORGANIZATION | 14 | 278 | 2.64e-06 | 0.0001862 |
67 | PROTEIN TARGETING | 17 | 406 | 2.785e-06 | 0.0001934 |
68 | MODULATION BY VIRUS OF HOST MORPHOLOGY OR PHYSIOLOGY | 6 | 37 | 2.893e-06 | 0.000198 |
69 | REGULATION OF CELLULAR PROTEIN LOCALIZATION | 20 | 552 | 3.316e-06 | 0.0002236 |
70 | POSITIVE REGULATION OF DNA BIOSYNTHETIC PROCESS | 7 | 59 | 3.718e-06 | 0.0002472 |
71 | MULTICELLULAR ORGANISM REPRODUCTION | 24 | 768 | 4.372e-06 | 0.0002865 |
72 | REGULATION OF MRNA SPLICING VIA SPLICEOSOME | 7 | 62 | 5.213e-06 | 0.0003369 |
73 | REPRODUCTION | 33 | 1297 | 5.654e-06 | 0.0003604 |
74 | MULTI ORGANISM REPRODUCTIVE PROCESS | 26 | 891 | 5.848e-06 | 0.0003677 |
75 | REGULATION OF PROTEIN LOCALIZATION | 27 | 950 | 6.185e-06 | 0.0003837 |
76 | POSITIVE REGULATION OF CHROMOSOME ORGANIZATION | 10 | 150 | 6.471e-06 | 0.0003956 |
77 | NEGATIVE REGULATION OF CELL CYCLE | 17 | 433 | 6.547e-06 | 0.0003956 |
78 | POSITIVE REGULATION OF RNA SPLICING | 5 | 25 | 6.833e-06 | 0.0004076 |
79 | NCRNA METABOLIC PROCESS | 19 | 533 | 7.422e-06 | 0.0004372 |
80 | POSITIVE REGULATION OF MRNA METABOLIC PROCESS | 6 | 45 | 9.42e-06 | 0.0005345 |
81 | MODIFICATION BY SYMBIONT OF HOST MORPHOLOGY OR PHYSIOLOGY | 6 | 45 | 9.42e-06 | 0.0005345 |
82 | REGULATION OF DNA BIOSYNTHETIC PROCESS | 8 | 94 | 9.33e-06 | 0.0005345 |
83 | RESPONSE TO ORGANIC CYCLIC COMPOUND | 26 | 917 | 9.716e-06 | 0.0005447 |
84 | CELL CYCLE CHECKPOINT | 11 | 194 | 1.052e-05 | 0.0005827 |
85 | POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION | 15 | 360 | 1.154e-05 | 0.0006317 |
86 | POSITIVE REGULATION OF TELOMERASE ACTIVITY | 5 | 28 | 1.23e-05 | 0.0006658 |
87 | POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS | 9 | 129 | 1.31e-05 | 0.0007005 |
88 | NUCLEOBASE CONTAINING COMPOUND TRANSPORT | 11 | 199 | 1.336e-05 | 0.0007067 |
89 | MRNA 3 END PROCESSING | 7 | 72 | 1.423e-05 | 0.0007438 |
90 | NEGATIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS | 9 | 131 | 1.483e-05 | 0.0007581 |
91 | RNA POLYADENYLATION | 5 | 29 | 1.474e-05 | 0.0007581 |
92 | DNA TEMPLATED TRANSCRIPTION TERMINATION | 8 | 101 | 1.586e-05 | 0.0008021 |
93 | PROTEIN PHOSPHORYLATION | 26 | 944 | 1.609e-05 | 0.0008048 |
94 | CELLULAR MACROMOLECULAR COMPLEX ASSEMBLY | 22 | 727 | 1.84e-05 | 0.0009109 |
95 | CELLULAR RESPONSE TO STRESS | 36 | 1565 | 1.875e-05 | 0.0009182 |
96 | RNA STABILIZATION | 5 | 31 | 2.071e-05 | 0.001004 |
97 | POSITIVE REGULATION OF MRNA PROCESSING | 5 | 32 | 2.433e-05 | 0.001167 |
98 | CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND | 23 | 799 | 2.59e-05 | 0.001226 |
99 | NUCLEIC ACID PHOSPHODIESTER BOND HYDROLYSIS | 12 | 254 | 2.609e-05 | 0.001226 |
100 | DNA INTEGRITY CHECKPOINT | 9 | 146 | 3.515e-05 | 0.001635 |
101 | PEPTIDYL SERINE MODIFICATION | 9 | 148 | 3.912e-05 | 0.001802 |
102 | CELLULAR RESPONSE TO HORMONE STIMULUS | 18 | 552 | 4.21e-05 | 0.00192 |
103 | CELLULAR RESPONSE TO LIPID | 16 | 457 | 4.932e-05 | 0.002228 |
104 | NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS | 19 | 616 | 5.431e-05 | 0.00243 |
105 | CELLULAR COMPONENT DISASSEMBLY | 17 | 515 | 5.944e-05 | 0.002634 |
106 | REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL | 12 | 280 | 6.71e-05 | 0.002946 |
107 | REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY | 16 | 470 | 6.864e-05 | 0.002985 |
108 | ANDROGEN RECEPTOR SIGNALING PATHWAY | 5 | 41 | 8.353e-05 | 0.003599 |
109 | DNA REPAIR | 16 | 480 | 8.776e-05 | 0.003746 |
110 | CELLULAR MACROMOLECULE LOCALIZATION | 29 | 1234 | 9.216e-05 | 0.003898 |
111 | REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY | 7 | 97 | 9.838e-05 | 0.004124 |
112 | INTRACELLULAR RECEPTOR SIGNALING PATHWAY | 9 | 168 | 0.0001044 | 0.004338 |
113 | REGULATION OF TELOMERASE ACTIVITY | 5 | 43 | 0.0001054 | 0.00434 |
114 | GAMETE GENERATION | 18 | 595 | 0.0001093 | 0.004463 |
115 | MODIFICATION OF MORPHOLOGY OR PHYSIOLOGY OF OTHER ORGANISM | 7 | 100 | 0.0001192 | 0.004824 |
116 | CELLULAR RESPONSE TO ORGANIC SUBSTANCE | 38 | 1848 | 0.0001207 | 0.00484 |
117 | CELLULAR CATABOLIC PROCESS | 30 | 1322 | 0.0001286 | 0.005071 |
118 | CELLULAR RESPONSE TO ENDOGENOUS STIMULUS | 25 | 1008 | 0.0001275 | 0.005071 |
119 | NUCLEUS ORGANIZATION | 8 | 136 | 0.000133 | 0.0052 |
120 | NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL | 8 | 139 | 0.0001547 | 0.00595 |
121 | TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 20 | 724 | 0.0001547 | 0.00595 |
122 | REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS | 10 | 218 | 0.0001569 | 0.005985 |
123 | MEMBRANE DISASSEMBLY | 5 | 47 | 0.0001621 | 0.006081 |
124 | NUCLEAR ENVELOPE DISASSEMBLY | 5 | 47 | 0.0001621 | 0.006081 |
125 | MRNA SPLICE SITE SELECTION | 4 | 26 | 0.0001761 | 0.006452 |
126 | REGULATION OF CELLULAR SENESCENCE | 4 | 26 | 0.0001761 | 0.006452 |
127 | REGULATION OF PROTEIN STABILITY | 10 | 221 | 0.0001754 | 0.006452 |
128 | REGULATION OF CELLULAR RESPONSE TO HEAT | 6 | 76 | 0.0001905 | 0.006924 |
129 | DNA CATABOLIC PROCESS | 4 | 27 | 0.000205 | 0.007393 |
130 | POSITIVE REGULATION OF DNA METABOLIC PROCESS | 9 | 185 | 0.0002161 | 0.007675 |
131 | PROTEASOMAL PROTEIN CATABOLIC PROCESS | 11 | 271 | 0.0002164 | 0.007675 |
132 | RNA CATABOLIC PROCESS | 10 | 227 | 0.0002177 | 0.007675 |
133 | MICROTUBULE BASED PROCESS | 16 | 522 | 0.0002285 | 0.007933 |
134 | NUCLEAR EXPORT | 8 | 147 | 0.0002271 | 0.007933 |
135 | DNA CONFORMATION CHANGE | 11 | 273 | 0.0002306 | 0.007947 |
136 | REGULATION OF NERVOUS SYSTEM DEVELOPMENT | 20 | 750 | 0.0002458 | 0.00841 |
137 | NEGATIVE REGULATION OF PHOSPHORYLATION | 14 | 422 | 0.0002548 | 0.008655 |
138 | PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION | 4 | 29 | 0.0002727 | 0.009193 |
139 | NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS | 32 | 1517 | 0.000284 | 0.009439 |
140 | RESPONSE TO ENDOGENOUS STIMULUS | 31 | 1450 | 0.0002831 | 0.009439 |
141 | POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 24 | 1004 | 0.0003015 | 0.00995 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | RNA BINDING | 100 | 1598 | 3.196e-51 | 2.969e-48 |
2 | POLY A RNA BINDING | 85 | 1170 | 1.419e-47 | 6.593e-45 |
3 | RIBONUCLEOTIDE BINDING | 70 | 1860 | 5.57e-21 | 1.725e-18 |
4 | ADENYL NUCLEOTIDE BINDING | 61 | 1514 | 1.472e-19 | 3.42e-17 |
5 | NUCLEAR LOCALIZATION SEQUENCE BINDING | 9 | 21 | 5.246e-13 | 9.747e-11 |
6 | RNA HELICASE ACTIVITY | 12 | 67 | 8.184e-12 | 1.267e-09 |
7 | HELICASE ACTIVITY | 16 | 153 | 1.346e-11 | 1.786e-09 |
8 | HYDROLASE ACTIVITY ACTING ON ACID ANHYDRIDES | 34 | 820 | 2.491e-11 | 2.893e-09 |
9 | PURINE NTP DEPENDENT HELICASE ACTIVITY | 13 | 98 | 5.708e-11 | 5.891e-09 |
10 | CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY | 9 | 34 | 8.27e-11 | 7.683e-09 |
11 | SIGNAL SEQUENCE BINDING | 9 | 39 | 3.186e-10 | 2.691e-08 |
12 | POLY PURINE TRACT BINDING | 7 | 19 | 7.978e-10 | 6.176e-08 |
13 | SINGLE STRANDED RNA BINDING | 10 | 69 | 4.08e-09 | 2.916e-07 |
14 | PROTEIN SERINE THREONINE KINASE ACTIVITY | 21 | 445 | 2.378e-08 | 1.578e-06 |
15 | HEAT SHOCK PROTEIN BINDING | 10 | 89 | 5.039e-08 | 3.121e-06 |
16 | ATPASE ACTIVITY | 20 | 427 | 5.894e-08 | 3.422e-06 |
17 | ATPASE ACTIVITY COUPLED | 17 | 313 | 7.42e-08 | 4.055e-06 |
18 | MRNA BINDING | 12 | 155 | 1.516e-07 | 7.824e-06 |
19 | PROTEIN TRANSPORTER ACTIVITY | 9 | 99 | 1.471e-06 | 7.19e-05 |
20 | CYCLIN BINDING | 5 | 19 | 1.578e-06 | 7.331e-05 |
21 | TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS | 28 | 992 | 4.669e-06 | 0.0002066 |
22 | ENZYME BINDING | 40 | 1737 | 5.773e-06 | 0.0002438 |
23 | PROTEIN KINASE ACTIVITY | 21 | 640 | 8.63e-06 | 0.0003486 |
24 | MACROMOLECULAR COMPLEX BINDING | 34 | 1399 | 1.064e-05 | 0.000412 |
25 | UNFOLDED PROTEIN BINDING | 8 | 100 | 1.474e-05 | 0.0005478 |
26 | DNA HELICASE ACTIVITY | 6 | 53 | 2.468e-05 | 0.0008817 |
27 | SINGLE STRANDED DNA BINDING | 7 | 93 | 7.529e-05 | 0.002412 |
28 | TRANSCRIPTION FACTOR BINDING | 17 | 524 | 7.348e-05 | 0.002412 |
29 | DOUBLE STRANDED RNA BINDING | 6 | 64 | 7.288e-05 | 0.002412 |
30 | GTPASE ACTIVITY | 11 | 246 | 9.276e-05 | 0.002872 |
31 | KINASE ACTIVITY | 22 | 842 | 0.0001598 | 0.004788 |
32 | MRNA 3 UTR BINDING | 5 | 48 | 0.0001793 | 0.005205 |
33 | HSP90 PROTEIN BINDING | 4 | 27 | 0.000205 | 0.00577 |
34 | POLY A BINDING | 3 | 13 | 0.0003461 | 0.009188 |
35 | CHROMATIN BINDING | 14 | 435 | 0.0003462 | 0.009188 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | RIBONUCLEOPROTEIN COMPLEX | 52 | 721 | 5.894e-28 | 3.442e-25 |
2 | SPLICEOSOMAL COMPLEX | 26 | 172 | 2.963e-22 | 8.651e-20 |
3 | CATALYTIC STEP 2 SPLICEOSOME | 17 | 89 | 1.021e-16 | 1.988e-14 |
4 | NUCLEOLUS | 41 | 848 | 9.175e-16 | 1.339e-13 |
5 | NUCLEAR BODY | 21 | 349 | 3.188e-10 | 3.723e-08 |
6 | NUCLEAR PORE | 11 | 77 | 7.856e-10 | 7.647e-08 |
7 | RIBONUCLEOPROTEIN GRANULE | 14 | 148 | 1.007e-09 | 8.404e-08 |
8 | NUCLEOPLASM PART | 27 | 708 | 1.983e-08 | 1.447e-06 |
9 | MICROTUBULE CYTOSKELETON | 34 | 1068 | 2.259e-08 | 1.466e-06 |
10 | NUCLEAR SPECK | 14 | 194 | 3.331e-08 | 1.945e-06 |
11 | NUCLEAR ENVELOPE | 18 | 416 | 8.8e-07 | 4.672e-05 |
12 | CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX | 6 | 31 | 9.682e-07 | 4.712e-05 |
13 | CYTOPLASMIC STRESS GRANULE | 6 | 32 | 1.181e-06 | 5.304e-05 |
14 | CYTOSKELETAL PART | 36 | 1436 | 2.795e-06 | 0.0001166 |
15 | SMALL NUCLEAR RIBONUCLEOPROTEIN COMPLEX | 7 | 60 | 4.171e-06 | 0.0001624 |
16 | CHROMOSOME | 26 | 880 | 4.686e-06 | 0.000171 |
17 | MICROTUBULE ORGANIZING CENTER | 21 | 623 | 5.728e-06 | 0.0001968 |
18 | PRP19 COMPLEX | 4 | 13 | 9.424e-06 | 0.0002897 |
19 | CHROMATOID BODY | 4 | 13 | 9.424e-06 | 0.0002897 |
20 | SPINDLE | 13 | 289 | 2.016e-05 | 0.0005887 |
21 | CAJAL BODY | 6 | 52 | 2.208e-05 | 0.0006142 |
22 | CENTROSOME | 17 | 487 | 2.967e-05 | 0.0007875 |
23 | CYTOSKELETON | 41 | 1967 | 4.561e-05 | 0.001158 |
24 | PROTEIN KINASE COMPLEX | 7 | 90 | 6.105e-05 | 0.001486 |
25 | SPINDLE POLE | 8 | 126 | 7.795e-05 | 0.001821 |
26 | CHROMATIN | 15 | 441 | 0.000117 | 0.002629 |
27 | MICROTUBULE | 14 | 405 | 0.0001672 | 0.003617 |
28 | ENDOPLASMIC RETICULUM CHAPERONE COMPLEX | 3 | 11 | 0.000203 | 0.004233 |
29 | NUCLEAR CHROMOSOME | 16 | 523 | 0.0002334 | 0.0047 |
30 | TRANSFERASE COMPLEX | 19 | 703 | 0.0002981 | 0.005802 |
31 | U2 TYPE SPLICEOSOMAL COMPLEX | 4 | 31 | 0.000355 | 0.006689 |
32 | NUCLEAR PERIPHERY | 7 | 121 | 0.0003873 | 0.007067 |
33 | NUCLEAR CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX | 3 | 15 | 0.0005418 | 0.009588 |
Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|---|
1 | hsa03040_Spliceosome | 26 | 128 | 9.908e-26 | 1.783e-23 | |
2 | hsa04110_Cell_cycle | 11 | 128 | 1.753e-07 | 1.578e-05 | |
3 | hsa03008_Ribosome_biogenesis_in_eukaryotes | 9 | 81 | 2.63e-07 | 1.578e-05 | |
4 | hsa04914_Progesterone.mediated_oocyte_maturation | 8 | 87 | 5.231e-06 | 0.0002354 | |
5 | hsa04114_Oocyte_meiosis | 8 | 114 | 3.823e-05 | 0.001376 | |
6 | hsa04520_Adherens_junction | 6 | 73 | 0.0001524 | 0.004573 | |
7 | hsa03015_mRNA_surveillance_pathway | 6 | 83 | 0.0003086 | 0.007934 | |
8 | hsa04540_Gap_junction | 6 | 90 | 0.0004776 | 0.01075 | |
9 | hsa04141_Protein_processing_in_endoplasmic_reticulum | 8 | 168 | 0.0005568 | 0.01114 | |
10 | hsa03018_RNA_degradation | 5 | 71 | 0.001111 | 0.02 | |
11 | hsa03013_RNA_transport | 7 | 152 | 0.00149 | 0.02438 | |
12 | hsa04710_Circadian_rhythm_._mammal | 3 | 23 | 0.001976 | 0.02965 | |
13 | hsa04310_Wnt_signaling_pathway | 6 | 151 | 0.006582 | 0.09065 | |
14 | hsa04115_p53_signaling_pathway | 4 | 69 | 0.00705 | 0.09065 | |
15 | hsa04151_PI3K_AKT_signaling_pathway | 9 | 351 | 0.01601 | 0.1921 | |
16 | hsa04390_Hippo_signaling_pathway | 5 | 154 | 0.02788 | 0.3097 | |
17 | hsa04145_Phagosome | 5 | 156 | 0.02925 | 0.3097 | |
18 | hsa00260_Glycine._serine_and_threonine_metabolism | 2 | 32 | 0.04814 | 0.4814 | |
19 | hsa04530_Tight_junction | 4 | 133 | 0.05944 | 0.5513 | |
20 | hsa04350_TGF.beta_signaling_pathway | 3 | 85 | 0.06734 | 0.5513 | |
21 | hsa04120_Ubiquitin_mediated_proteolysis | 4 | 139 | 0.06762 | 0.5513 | |
22 | hsa04510_Focal_adhesion | 5 | 200 | 0.07044 | 0.5513 | |
23 | hsa04210_Apoptosis | 3 | 89 | 0.07505 | 0.5606 | |
24 | hsa04960_Aldosterone.regulated_sodium_reabsorption | 2 | 42 | 0.07787 | 0.5606 | |
25 | hsa04810_Regulation_of_actin_cytoskeleton | 5 | 214 | 0.088 | 0.6092 | |
26 | hsa04916_Melanogenesis | 3 | 101 | 0.1003 | 0.6689 | |
27 | hsa04150_mTOR_signaling_pathway | 2 | 52 | 0.1118 | 0.7112 | |
28 | hsa04621_NOD.like_receptor_signaling_pathway | 2 | 59 | 0.1374 | 0.8043 | |
29 | hsa04670_Leukocyte_transendothelial_migration | 3 | 117 | 0.1385 | 0.8043 | |
30 | hsa04360_Axon_guidance | 3 | 130 | 0.1726 | 0.8993 | |
31 | hsa04010_MAPK_signaling_pathway | 5 | 268 | 0.1739 | 0.8993 | |
32 | hsa04720_Long.term_potentiation | 2 | 70 | 0.1799 | 0.8993 | |
33 | hsa04730_Long.term_depression | 2 | 70 | 0.1799 | 0.8993 | |
34 | hsa04910_Insulin_signaling_pathway | 3 | 138 | 0.1946 | 0.9404 | |
35 | hsa04662_B_cell_receptor_signaling_pathway | 2 | 75 | 0.1997 | 0.9404 | |
36 | hsa04370_VEGF_signaling_pathway | 2 | 76 | 0.2037 | 0.9404 | |
37 | hsa00230_Purine_metabolism | 3 | 162 | 0.264 | 1 | |
38 | hsa00240_Pyrimidine_metabolism | 2 | 99 | 0.2972 | 1 | |
39 | hsa04912_GnRH_signaling_pathway | 2 | 101 | 0.3053 | 1 | |
40 | hsa04620_Toll.like_receptor_signaling_pathway | 2 | 102 | 0.3094 | 1 | |
41 | hsa04660_T_cell_receptor_signaling_pathway | 2 | 108 | 0.3336 | 1 | |
42 | hsa04270_Vascular_smooth_muscle_contraction | 2 | 116 | 0.3655 | 1 | |
43 | hsa04144_Endocytosis | 3 | 203 | 0.3868 | 1 | |
44 | hsa04722_Neurotrophin_signaling_pathway | 2 | 127 | 0.4083 | 1 | |
45 | hsa04380_Osteoclast_differentiation | 2 | 128 | 0.4121 | 1 | |
46 | hsa04650_Natural_killer_cell_mediated_cytotoxicity | 2 | 136 | 0.4423 | 1 | |
47 | hsa04020_Calcium_signaling_pathway | 2 | 177 | 0.5821 | 1 |