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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106a-5p AKT3 -0.2 0.80221 0.46 0.53933 miRNATAP -0.55 0 NA
2 hsa-miR-106b-5p AKT3 -0.3 0.86929 0.46 0.53933 miRNATAP -0.91 0 NA
3 hsa-miR-107 AKT3 -0.04 0.98836 0.46 0.53933 PITA; miRanda -0.55 0.00017 NA
4 hsa-miR-1275 AKT3 -0.83 0.08038 0.46 0.53933 PITA -0.27 0 NA
5 hsa-miR-142-3p AKT3 -0.15 0.9461 0.46 0.53933 miRanda -0.2 0.00627 NA
6 hsa-miR-15a-5p AKT3 -0.07 0.96484 0.46 0.53933 miRNAWalker2 validate; miRTarBase; miRNATAP -0.72 0 NA
7 hsa-miR-15b-5p AKT3 -0.27 0.87097 0.46 0.53933 miRNATAP -0.67 0 NA
8 hsa-miR-16-5p AKT3 0.01 0.99448 0.46 0.53933 miRNAWalker2 validate; miRTarBase; miRNATAP -0.75 0 NA
9 hsa-miR-17-3p AKT3 0.1 0.96011 0.46 0.53933 miRNATAP -0.52 0 NA
10 hsa-miR-17-5p AKT3 -0.18 0.93454 0.46 0.53933 TargetScan; miRNATAP -0.63 0 NA
11 hsa-miR-181b-5p AKT3 0.16 0.93018 0.46 0.53933 miRNATAP -0.27 0.00963 NA
12 hsa-miR-20a-5p AKT3 -0.18 0.92812 0.46 0.53933 miRNATAP -0.53 0 NA
13 hsa-miR-28-3p AKT3 -0.23 0.93535 0.46 0.53933 miRNATAP -0.52 0.00719 NA
14 hsa-miR-29a-3p AKT3 0.01 0.99698 0.46 0.53933 miRNATAP -0.81 0 NA
15 hsa-miR-29b-3p AKT3 -0.1 0.95899 0.46 0.53933 miRNATAP -0.68 0 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
16 hsa-miR-32-3p AKT3 -0.57 0.13133 0.46 0.53933 mirMAP -0.56 0 NA
17 hsa-miR-320a AKT3 -0.42 0.8402 0.46 0.53933 PITA; miRanda; miRNATAP -0.33 0.00138 NA
18 hsa-miR-320b AKT3 -0.24 0.85922 0.46 0.53933 PITA; miRanda; miRNATAP -0.25 0.00855 NA
19 hsa-miR-335-3p AKT3 -0.24 0.8845 0.46 0.53933 mirMAP -0.58 0 NA
20 hsa-miR-33a-3p AKT3 -0.79 0.01052 0.46 0.53933 mirMAP -0.49 0 NA
21 hsa-miR-340-5p AKT3 -0 0.99757 0.46 0.53933 mirMAP -0.28 0.006 NA
22 hsa-miR-362-3p AKT3 -0.72 0.03459 0.46 0.53933 miRanda -0.42 0 NA
23 hsa-miR-362-5p AKT3 -0.27 0.75202 0.46 0.53933 PITA; TargetScan; miRNATAP -0.52 0 NA
24 hsa-miR-369-3p AKT3 0.12 0.8323 0.46 0.53933 mirMAP -0.23 0.00901 NA
25 hsa-miR-374a-5p AKT3 -0.34 0.76692 0.46 0.53933 mirMAP -0.58 0 NA
26 hsa-miR-374b-5p AKT3 -0.29 0.8357 0.46 0.53933 mirMAP -0.68 0 NA
27 hsa-miR-421 AKT3 -0.18 0.7347 0.46 0.53933 miRanda; mirMAP -0.46 0 NA
28 hsa-miR-424-5p AKT3 0.25 0.87015 0.46 0.53933 miRNATAP -0.24 0.00104 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth
29 hsa-miR-501-3p AKT3 -0.75 0.55276 0.46 0.53933 miRNATAP -0.5 0 NA
30 hsa-miR-502-3p AKT3 -0.48 0.5143 0.46 0.53933 miRNATAP -0.64 0 NA
31 hsa-miR-502-5p AKT3 -0.71 0.02613 0.46 0.53933 PITA; miRNATAP -0.41 0 NA
32 hsa-miR-505-3p AKT3 -0.47 0.69038 0.46 0.53933 mirMAP -0.77 0 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR
33 hsa-miR-548o-3p AKT3 -0.19 0.51773 0.46 0.53933 mirMAP -0.31 8.0E-5 NA
34 hsa-miR-577 AKT3 -1.06 0.32606 0.46 0.53933 mirMAP -0.38 0 NA
35 hsa-miR-663b AKT3 0.1 0.81499 0.46 0.53933 PITA -0.25 1.0E-5 NA
36 hsa-miR-769-5p AKT3 -0.31 0.7357 0.46 0.53933 PITA; miRNATAP -0.84 0 NA
37 hsa-miR-93-5p AKT3 -0.61 0.8253 0.46 0.53933 miRNATAP -0.76 0 NA
38 hsa-miR-143-5p CDC42 0.11 0.93336 -0.15 0.93702 miRNATAP -0.12 2.0E-5 NA
39 hsa-miR-125a-3p KDR 0.15 0.72476 -0.04 0.969 miRanda -0.14 0.00574 NA
40 hsa-miR-149-5p KDR -0.03 0.96106 -0.04 0.969 miRNATAP -0.18 0.00029 NA
41 hsa-miR-15a-5p KDR -0.07 0.96484 -0.04 0.969 miRNATAP -0.25 0.00079 NA
42 hsa-miR-15b-5p KDR -0.27 0.87097 -0.04 0.969 miRNATAP -0.33 0 NA
43 hsa-miR-16-5p KDR 0.01 0.99448 -0.04 0.969 miRTarBase; miRNATAP -0.37 0 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2
44 hsa-miR-200b-3p KDR -0.43 0.86396 -0.04 0.969 miRNAWalker2 validate; miRTarBase; TargetScan -0.24 7.0E-5 NA
45 hsa-miR-200c-3p KDR -0.44 0.88712 -0.04 0.969 miRNATAP -0.24 0.00011 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c
46 hsa-miR-335-5p KDR -0.03 0.97338 -0.04 0.969 miRNAWalker2 validate -0.3 0 NA
47 hsa-miR-429 KDR -0.46 0.80624 -0.04 0.969 PITA; miRanda; miRNATAP -0.23 0 NA
48 hsa-miR-590-3p KDR -0.28 0.59127 -0.04 0.969 miRanda -0.32 0 NA
49 hsa-miR-590-5p KDR -0.55 0.47274 -0.04 0.969 miRanda -0.33 0 NA
50 hsa-miR-126-5p KRAS 0.08 0.95664 0.08 0.95389 MirTarget -0.12 0.00133 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK
51 hsa-miR-1271-5p KRAS -0.46 0.09563 0.08 0.95389 MirTarget -0.11 8.0E-5 NA
52 hsa-miR-181c-5p KRAS 0.04 0.96916 0.08 0.95389 miRNAWalker2 validate; miRTarBase -0.1 0.0009 NA
53 hsa-miR-199a-5p KRAS 0.16 0.9358 0.08 0.95389 miRanda; miRNATAP -0.11 0.0009 NA
54 hsa-miR-199b-5p KRAS -0.04 0.97717 0.08 0.95389 miRanda; miRNATAP -0.11 0.0001 27517624 The miR-199b prognostic impact was particularly evident in both younger and KRAS wild-type subgroups
55 hsa-miR-30e-5p KRAS -0.07 0.97968 0.08 0.95389 mirMAP; miRNATAP -0.12 0.00857 NA
56 hsa-miR-101-3p MAP2K1 0.01 0.99704 -0.08 0.95198 miRNAWalker2 validate -0.18 2.0E-5 NA
57 hsa-miR-34c-5p MAP2K1 -0.02 0.95279 -0.08 0.95198 PITA; miRanda -0.11 0.0001 NA
58 hsa-miR-497-5p MAP2K1 -0.01 0.98915 -0.08 0.95198 miRNAWalker2 validate -0.15 1.0E-5 NA
59 hsa-miR-34c-5p MAPK13 -0.02 0.95279 0.09 0.95638 miRanda; miRNATAP -0.12 0.0038 NA
60 hsa-miR-125a-3p MAPK14 0.15 0.72476 0.13 0.93083 miRanda -0.1 0 NA
61 hsa-miR-125a-5p MAPK14 -0 0.99916 0.13 0.93083 PITA; miRanda; miRNATAP -0.13 0.00034 NA
62 hsa-miR-142-5p MAPK14 -0.12 0.92967 0.13 0.93083 PITA -0.13 0 NA
63 hsa-miR-145-3p MAPK14 0.13 0.91316 0.13 0.93083 MirTarget; miRNATAP -0.1 0.00177 NA
64 hsa-miR-22-3p MAPK14 0.06 0.98656 0.13 0.93083 MirTarget; miRNATAP -0.17 0.00042 NA
65 hsa-miR-27a-3p MAPK14 -0.12 0.9588 0.13 0.93083 MirTarget; miRNATAP -0.12 0.00681 NA
66 hsa-miR-27b-3p MAPK14 -0.14 0.95194 0.13 0.93083 MirTarget; miRNATAP -0.14 0.00597 NA
67 hsa-miR-320b MAPK14 -0.24 0.85922 0.13 0.93083 PITA; miRanda -0.11 0.00016 NA
68 hsa-miR-342-3p MAPK14 -0.37 0.77314 0.13 0.93083 miRanda -0.14 0 NA
69 hsa-miR-132-3p NFAT5 -0.24 0.87175 0.24 0.86876 miRNATAP -0.3 0 NA
70 hsa-miR-140-3p NFAT5 -0.37 0.86476 0.24 0.86876 miRNATAP -0.23 0.00235 NA
71 hsa-miR-146b-5p NFAT5 -0.4 0.83751 0.24 0.86876 miRanda -0.2 3.0E-5 NA
72 hsa-miR-155-5p NFAT5 -0.41 0.82867 0.24 0.86876 mirMAP; miRNATAP -0.15 0.00026 NA
73 hsa-miR-21-3p NFAT5 -0.4 0.8782 0.24 0.86876 MirTarget -0.18 0.00029 NA
74 hsa-miR-21-5p NFAT5 -0.15 0.97024 0.24 0.86876 miRNAWalker2 validate; mirMAP -0.29 5.0E-5 NA
75 hsa-miR-511-5p NFAT5 -0.31 0.6072 0.24 0.86876 MirTarget -0.11 0.00293 NA
76 hsa-miR-582-3p NFAT5 -0.23 0.89768 0.24 0.86876 MirTarget -0.17 0.0001 NA
77 hsa-miR-582-5p NFAT5 -0.4 0.58123 0.24 0.86876 MirTarget; PITA; miRNATAP -0.15 0.0014 NA
78 hsa-miR-889-3p NFAT5 0.17 0.84879 0.24 0.86876 MirTarget -0.17 0.00648 NA
79 hsa-miR-92b-3p NFAT5 -0.57 0.68932 0.24 0.86876 miRNATAP -0.18 0 NA
80 hsa-miR-421 NFATC1 -0.18 0.7347 -0.12 0.85235 miRanda -0.58 0 NA
81 hsa-miR-940 NFATC1 -0.23 0.68006 -0.12 0.85235 PITA -0.3 1.0E-5 NA
82 hsa-miR-130b-5p NFATC2 -0.65 0.3791 0.21 0.70733 MirTarget -0.37 0.00095 NA
83 hsa-miR-16-2-3p NFATC2 -0.37 0.54685 0.21 0.70733 mirMAP -0.32 0.0026 NA
84 hsa-miR-182-5p NFATC2 -0.1 0.97338 0.21 0.70733 mirMAP -0.27 0.00971 NA
85 hsa-miR-200b-5p NFATC2 -0.5 0.72226 0.21 0.70733 mirMAP -0.31 0.00378 NA
86 hsa-miR-26b-3p NFATC2 -0.36 0.68112 0.21 0.70733 MirTarget -0.32 0.00865 NA
87 hsa-miR-31-3p NFATC2 0.2 0.76203 0.21 0.70733 MirTarget -0.24 1.0E-5 NA
88 hsa-miR-340-5p NFATC2 -0 0.99757 0.21 0.70733 miRNATAP -0.35 0.00984 NA
89 hsa-miR-484 NFATC2 -0.18 0.88633 0.21 0.70733 MirTarget -0.42 0.00431 NA
90 hsa-miR-590-3p NFATC2 -0.28 0.59127 0.21 0.70733 mirMAP -0.34 0.00047 NA
91 hsa-miR-7-1-3p NFATC2 -0.46 0.6659 0.21 0.70733 mirMAP -0.33 0.00324 NA
92 hsa-miR-7-5p NFATC2 0.21 0.77371 0.21 0.70733 MirTarget; miRNATAP -0.22 0.00223 NA
93 hsa-miR-1254 NFATC4 -0.49 0.19552 0.23 0.8009 MirTarget -0.17 0.00079 NA
94 hsa-miR-130b-5p NFATC4 -0.65 0.3791 0.23 0.8009 mirMAP -0.23 0.00013 NA
95 hsa-miR-15b-3p NFATC4 -0.56 0.60918 0.23 0.8009 mirMAP -0.27 3.0E-5 NA
96 hsa-miR-29a-3p NFATC4 0.01 0.99698 0.23 0.8009 miRNATAP -0.26 0.00188 NA
97 hsa-miR-29b-3p NFATC4 -0.1 0.95899 0.23 0.8009 miRNATAP -0.23 0.00033 NA
98 hsa-miR-320c NFATC4 -0.58 0.1136 0.23 0.8009 miRanda; mirMAP -0.14 0.00652 NA
99 hsa-miR-361-3p NFATC4 -0.29 0.84773 0.23 0.8009 mirMAP -0.24 0.00961 NA
100 hsa-miR-429 NFATC4 -0.46 0.80624 0.23 0.8009 miRNATAP -0.21 2.0E-5 NA
101 hsa-miR-532-5p NFATC4 -0.35 0.87895 0.23 0.8009 mirMAP -0.26 3.0E-5 NA
102 hsa-miR-625-5p NFATC4 -0.69 0.21031 0.23 0.8009 mirMAP -0.14 0.00216 NA
103 hsa-miR-629-3p NFATC4 -0.5 0.33397 0.23 0.8009 mirMAP -0.2 9.0E-5 NA
104 hsa-miR-429 NOS3 -0.46 0.80624 0.4 0.68809 miRanda -0.15 0.0031 NA
105 hsa-let-7e-5p NRAS 0.21 0.92234 -0.12 0.93258 MirTarget; miRNATAP -0.13 0.00397 NA
106 hsa-let-7f-1-3p PIK3CA -0.31 0.69341 0.02 0.97942 mirMAP -0.12 0.00648 NA
107 hsa-miR-148a-5p PIK3CA -0.45 0.74842 0.02 0.97942 mirMAP -0.11 7.0E-5 NA
108 hsa-miR-148b-3p PIK3CA -0.2 0.91188 0.02 0.97942 miRNAWalker2 validate -0.12 0.00491 NA
109 hsa-miR-16-2-3p PIK3CA -0.37 0.54685 0.02 0.97942 mirMAP -0.1 9.0E-5 NA
110 hsa-miR-17-5p PIK3CA -0.18 0.93454 0.02 0.97942 miRNAWalker2 validate -0.12 0 NA
111 hsa-miR-186-5p PIK3CA -0.32 0.85413 0.02 0.97942 mirMAP -0.15 0.00027 NA
112 hsa-miR-32-3p PIK3CA -0.57 0.13133 0.02 0.97942 mirMAP -0.11 0 NA
113 hsa-miR-335-5p PIK3CA -0.03 0.97338 0.02 0.97942 miRNAWalker2 validate -0.1 0.0001 NA
114 hsa-miR-339-5p PIK3CA -0.3 0.71291 0.02 0.97942 miRanda -0.1 1.0E-5 NA
115 hsa-miR-374b-5p PIK3CA -0.29 0.8357 0.02 0.97942 mirMAP -0.14 0.00032 NA
116 hsa-miR-501-5p PIK3CA -0.83 0.05827 0.02 0.97942 mirMAP -0.11 0 NA
117 hsa-miR-576-5p PIK3CA -0.51 0.41719 0.02 0.97942 PITA -0.11 7.0E-5 NA
118 hsa-miR-582-3p PIK3CA -0.23 0.89768 0.02 0.97942 miRNATAP -0.14 0 NA
119 hsa-miR-590-3p PIK3CA -0.28 0.59127 0.02 0.97942 miRanda; mirMAP -0.12 0 NA
120 hsa-miR-590-5p PIK3CA -0.55 0.47274 0.02 0.97942 miRanda -0.14 0 NA
121 hsa-miR-96-5p PIK3CA 0.09 0.92309 0.02 0.97942 TargetScan -0.13 0 NA
122 hsa-miR-1468-5p PIK3CD -0.2 0.68841 -0.05 0.94703 MirTarget -0.29 0.00025 NA
123 hsa-miR-29a-3p PIK3CD 0.01 0.99698 -0.05 0.94703 mirMAP -0.35 0.00244 NA
124 hsa-miR-29b-3p PIK3CD -0.1 0.95899 -0.05 0.94703 mirMAP -0.26 0.00266 NA
125 hsa-miR-30b-5p PIK3CD -0.01 0.99462 -0.05 0.94703 MirTarget -0.4 0 NA
126 hsa-miR-30c-5p PIK3CD -0.3 0.86581 -0.05 0.94703 MirTarget; miRNATAP -0.42 0.00071 NA
127 hsa-miR-30d-5p PIK3CD -0.17 0.95173 -0.05 0.94703 MirTarget; miRNATAP -0.36 0.00123 NA
128 hsa-miR-421 PIK3CD -0.18 0.7347 -0.05 0.94703 miRanda -0.49 0 NA
129 hsa-miR-484 PIK3CD -0.18 0.88633 -0.05 0.94703 MirTarget; miRNATAP -0.35 0.00143 NA
130 hsa-miR-7-5p PIK3CD 0.21 0.77371 -0.05 0.94703 miRTarBase; MirTarget; miRNATAP -0.2 0.00035 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway
131 hsa-miR-942-5p PIK3CD -0.51 0.50778 -0.05 0.94703 MirTarget -0.19 0.00863 NA
132 hsa-miR-126-3p PIK3CG -0.11 0.96367 -0.36 0.46972 miRTarBase -0.53 0.00048 NA
133 hsa-miR-26b-5p PIK3CG -0.02 0.99038 -0.36 0.46972 miRNAWalker2 validate -0.8 0 NA
134 hsa-miR-29b-3p PIK3CG -0.1 0.95899 -0.36 0.46972 miRTarBase -0.67 0 NA
135 hsa-miR-335-3p PIK3CG -0.24 0.8845 -0.36 0.46972 mirMAP -0.56 0 NA
136 hsa-miR-421 PIK3CG -0.18 0.7347 -0.36 0.46972 miRanda -0.44 0.00013 NA
137 hsa-miR-502-5p PIK3CG -0.71 0.02613 -0.36 0.46972 miRNATAP -0.34 0.00065 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells
138 hsa-miR-590-3p PIK3CG -0.28 0.59127 -0.36 0.46972 miRanda -0.44 1.0E-5 NA
139 hsa-miR-132-3p PIK3R1 -0.24 0.87175 -0.11 0.93752 MirTarget -0.19 0.0073 NA
140 hsa-miR-15a-5p PIK3R1 -0.07 0.96484 -0.11 0.93752 MirTarget -0.22 9.0E-5 NA
141 hsa-miR-15b-5p PIK3R1 -0.27 0.87097 -0.11 0.93752 MirTarget -0.14 0.00644 NA
142 hsa-miR-16-5p PIK3R1 0.01 0.99448 -0.11 0.93752 MirTarget -0.19 0.00026 NA
143 hsa-miR-185-5p PIK3R1 -0.29 0.82059 -0.11 0.93752 miRNATAP -0.24 0.00027 NA
144 hsa-miR-21-5p PIK3R1 -0.15 0.97024 -0.11 0.93752 miRNAWalker2 validate; MirTarget; miRNATAP -0.32 4.0E-5 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer
145 hsa-miR-212-3p PIK3R1 -0.02 0.97323 -0.11 0.93752 MirTarget -0.23 5.0E-5 NA
146 hsa-miR-22-5p PIK3R1 -0.08 0.9317 -0.11 0.93752 mirMAP -0.19 3.0E-5 NA
147 hsa-miR-221-3p PIK3R1 0.09 0.95912 -0.11 0.93752 MirTarget -0.2 0.00053 NA
148 hsa-miR-222-3p PIK3R1 -0.03 0.98401 -0.11 0.93752 MirTarget -0.2 6.0E-5 NA
149 hsa-miR-369-3p PIK3R1 0.12 0.8323 -0.11 0.93752 PITA -0.17 0.00038 NA
150 hsa-miR-424-5p PIK3R1 0.25 0.87015 -0.11 0.93752 MirTarget -0.12 0.00204 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF RESPONSE TO STIMULUS 32 1929 8.839e-26 4.113e-22
2 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 31 1977 6.325e-24 1.471e-20
3 INTRACELLULAR SIGNAL TRANSDUCTION 28 1572 2.08e-22 3.226e-19
4 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 17 323 1.44e-20 1.675e-17
5 FC RECEPTOR SIGNALING PATHWAY 15 206 2.984e-20 2.777e-17
6 GLYCEROLIPID BIOSYNTHETIC PROCESS 14 211 2.496e-18 1.936e-15
7 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 15 297 7.621e-18 5.066e-15
8 PHOSPHOLIPID BIOSYNTHETIC PROCESS 14 235 1.147e-17 6.67e-15
9 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 13 193 4.009e-17 2.073e-14
10 GLYCEROLIPID METABOLIC PROCESS 15 356 1.143e-16 5.32e-14
11 PHOSPHOLIPID METABOLIC PROCESS 15 364 1.591e-16 6.73e-14
12 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 10 74 1.982e-16 7.684e-14
13 REGULATION OF IMMUNE SYSTEM PROCESS 22 1403 1.164e-15 4.166e-13
14 LIPID BIOSYNTHETIC PROCESS 16 539 2.15e-15 7.145e-13
15 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 23 1656 2.511e-15 7.789e-13
16 FC EPSILON RECEPTOR SIGNALING PATHWAY 11 142 3.024e-15 8.794e-13
17 POSITIVE REGULATION OF CELL COMMUNICATION 22 1532 7.256e-15 1.986e-12
18 PHOSPHATIDYLETHANOLAMINE ACYL CHAIN REMODELING 7 23 1.76e-14 4.551e-12
19 CELLULAR LIPID METABOLIC PROCESS 18 913 2.758e-14 6.755e-12
20 PHOSPHATIDYLCHOLINE ACYL CHAIN REMODELING 7 26 4.703e-14 1.094e-11
21 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 14 450 9.491e-14 2.103e-11
22 CALCIUM MEDIATED SIGNALING 9 90 1.224e-13 2.589e-11
23 REGULATION OF IMMUNE RESPONSE 17 858 1.693e-13 3.283e-11
24 VASCULATURE DEVELOPMENT 14 469 1.668e-13 3.283e-11
25 PHOSPHATIDYLGLYCEROL METABOLIC PROCESS 7 31 1.866e-13 3.474e-11
26 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 22 1805 2.123e-13 3.799e-11
27 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 17 876 2.37e-13 4.083e-11
28 PHOSPHORYLATION 19 1228 3.141e-13 5.219e-11
29 PHOSPHATIDYLGLYCEROL ACYL CHAIN REMODELING 6 17 5.263e-13 8.444e-11
30 SECOND MESSENGER MEDIATED SIGNALING 10 160 5.576e-13 8.648e-11
31 INOSITOL PHOSPHATE MEDIATED SIGNALING 6 18 7.883e-13 1.183e-10
32 LOCOMOTION 18 1114 8.205e-13 1.193e-10
33 ACTIVATION OF IMMUNE RESPONSE 13 427 1.139e-12 1.606e-10
34 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 40 1.306e-12 1.788e-10
35 IMMUNE SYSTEM PROCESS 22 1984 1.452e-12 1.93e-10
36 LIPID METABOLIC PROCESS 18 1158 1.578e-12 2.04e-10
37 REGULATION OF TRANSPORT 21 1804 2.499e-12 3.142e-10
38 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 16 867 3.21e-12 3.93e-10
39 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 17 1036 3.507e-12 4.079e-10
40 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 17 1036 3.507e-12 4.079e-10
41 REGULATION OF PHOSPHORUS METABOLIC PROCESS 20 1618 3.665e-12 4.16e-10
42 REGULATION OF LIPID KINASE ACTIVITY 7 48 5.099e-12 5.649e-10
43 REGULATION OF LIPID METABOLIC PROCESS 11 282 5.799e-12 6.275e-10
44 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 7 51 7.983e-12 8.075e-10
45 REGULATION OF CELL DEATH 19 1472 7.763e-12 8.075e-10
46 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 13 498 7.89e-12 8.075e-10
47 ANGIOGENESIS 11 293 8.77e-12 8.683e-10
48 POSITIVE REGULATION OF TRANSPORT 16 936 1.018e-11 9.87e-10
49 PROTEIN PHOSPHORYLATION 16 944 1.157e-11 1.099e-09
50 FC GAMMA RECEPTOR SIGNALING PATHWAY 8 95 1.302e-11 1.212e-09
51 CELL MOTILITY 15 835 2.732e-11 2.398e-09
52 LOCALIZATION OF CELL 15 835 2.732e-11 2.398e-09
53 POSITIVE REGULATION OF PROTEIN IMPORT 8 104 2.725e-11 2.398e-09
54 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 7 61 2.965e-11 2.555e-09
55 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 18 1395 3.547e-11 3.001e-09
56 POSITIVE REGULATION OF IMMUNE RESPONSE 13 563 3.644e-11 3.027e-09
57 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 16 1021 3.741e-11 3.053e-09
58 CELL ACTIVATION 13 568 4.066e-11 3.262e-09
59 PHOSPHATIDYLCHOLINE METABOLIC PROCESS 7 64 4.204e-11 3.315e-09
60 ORGANOPHOSPHATE METABOLIC PROCESS 15 885 6.194e-11 4.803e-09
61 LEUKOCYTE MIGRATION 10 259 6.718e-11 5.124e-09
62 POSITIVE REGULATION OF MAPK CASCADE 12 470 7.59e-11 5.696e-09
63 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 11 360 8.001e-11 5.909e-09
64 REGULATION OF RESPONSE TO STRESS 18 1468 8.235e-11 5.987e-09
65 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 8 120 8.688e-11 6.219e-09
66 BLOOD VESSEL MORPHOGENESIS 11 364 9.002e-11 6.346e-09
67 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 8 121 9.289e-11 6.378e-09
68 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 17 1275 9.321e-11 6.378e-09
69 PHOSPHATIDYLINOSITOL ACYL CHAIN REMODELING 5 16 1.061e-10 7.156e-09
70 PHOSPHATIDYLSERINE ACYL CHAIN REMODELING 5 17 1.501e-10 9.978e-09
71 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 8 129 1.556e-10 1.02e-08
72 CARDIOVASCULAR SYSTEM DEVELOPMENT 14 788 1.734e-10 1.105e-08
73 CIRCULATORY SYSTEM DEVELOPMENT 14 788 1.734e-10 1.105e-08
74 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 16 1135 1.799e-10 1.131e-08
75 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 12 514 2.122e-10 1.317e-08
76 ETHANOLAMINE CONTAINING COMPOUND METABOLIC PROCESS 7 85 3.24e-10 1.984e-08
77 PLATELET ACTIVATION 8 142 3.361e-10 2.031e-08
78 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 13 689 4.391e-10 2.619e-08
79 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 6 49 5.676e-10 3.343e-08
80 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 7 95 7.15e-10 4.158e-08
81 LIPID PHOSPHORYLATION 7 99 9.577e-10 5.501e-08
82 LIPID CATABOLIC PROCESS 9 247 1.132e-09 6.422e-08
83 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 55 1.166e-09 6.538e-08
84 POSITIVE REGULATION OF GENE EXPRESSION 18 1733 1.233e-09 6.828e-08
85 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 25 1.274e-09 6.974e-08
86 AMMONIUM ION METABOLIC PROCESS 8 169 1.345e-09 7.275e-08
87 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 9 258 1.66e-09 8.877e-08
88 REGULATION OF INTRACELLULAR TRANSPORT 12 621 1.822e-09 9.635e-08
89 REGULATION OF KINASE ACTIVITY 13 776 1.865e-09 9.749e-08
90 IMMUNE EFFECTOR PROCESS 11 486 1.907e-09 9.86e-08
91 REGULATION OF PROTEIN LOCALIZATION 14 950 1.977e-09 1.011e-07
92 SINGLE ORGANISM BIOSYNTHETIC PROCESS 16 1340 2.04e-09 1.032e-07
93 POSITIVE REGULATION OF MOLECULAR FUNCTION 18 1791 2.094e-09 1.042e-07
94 REGULATION OF CELL ADHESION 12 629 2.105e-09 1.042e-07
95 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 15 1142 2.127e-09 1.042e-07
96 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 14 957 2.173e-09 1.042e-07
97 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 10 370 2.152e-09 1.042e-07
98 PHOSPHATIDYLSERINE METABOLIC PROCESS 5 28 2.346e-09 1.114e-07
99 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 15 1152 2.397e-09 1.126e-07
100 REGULATION OF PROTEIN IMPORT 8 183 2.524e-09 1.174e-07
101 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 13 799 2.654e-09 1.223e-07
102 REGULATION OF BODY FLUID LEVELS 11 506 2.906e-09 1.325e-07
103 RESPONSE TO OXYGEN CONTAINING COMPOUND 16 1381 3.153e-09 1.425e-07
104 PHAGOCYTOSIS 8 190 3.394e-09 1.518e-07
105 REGULATION OF MAPK CASCADE 12 660 3.617e-09 1.603e-07
106 LEUKOCYTE DIFFERENTIATION 9 292 4.902e-09 2.152e-07
107 PHOSPHATIDIC ACID METABOLIC PROCESS 5 33 5.625e-09 2.446e-07
108 RESPONSE TO NITROGEN COMPOUND 13 859 6.337e-09 2.73e-07
109 AMINE METABOLIC PROCESS 7 131 6.854e-09 2.926e-07
110 POSITIVE REGULATION OF LOCOMOTION 10 420 7.239e-09 3.035e-07
111 REGULATION OF CELLULAR PROTEIN LOCALIZATION 11 552 7.175e-09 3.035e-07
112 LIPID MODIFICATION 8 210 7.451e-09 3.096e-07
113 ALDITOL PHOSPHATE METABOLIC PROCESS 5 35 7.671e-09 3.131e-07
114 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 7 133 7.618e-09 3.131e-07
115 HEMOSTASIS 9 311 8.481e-09 3.431e-07
116 REGULATION OF CELL DIFFERENTIATION 16 1492 9.567e-09 3.805e-07
117 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 16 1492 9.567e-09 3.805e-07
118 REGULATION OF CELLULAR LOCALIZATION 15 1277 9.717e-09 3.832e-07
119 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 8 218 9.984e-09 3.871e-07
120 REGULATION OF CELL PROLIFERATION 16 1496 9.94e-09 3.871e-07
121 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 8 220 1.072e-08 4.118e-07
122 ERBB SIGNALING PATHWAY 6 79 1.08e-08 4.118e-07
123 IMMUNE SYSTEM DEVELOPMENT 11 582 1.239e-08 4.688e-07
124 ERBB2 SIGNALING PATHWAY 5 39 1.353e-08 5.075e-07
125 HOMEOSTATIC PROCESS 15 1337 1.803e-08 6.71e-07
126 REGULATION OF TRANSFERASE ACTIVITY 13 946 2e-08 7.386e-07
127 WOUND HEALING 10 470 2.104e-08 7.71e-07
128 ALCOHOL METABOLIC PROCESS 9 348 2.242e-08 8.149e-07
129 REGULATION OF CYTOPLASMIC TRANSPORT 10 481 2.618e-08 9.442e-07
130 POSITIVE REGULATION OF KINASE ACTIVITY 10 482 2.67e-08 9.555e-07
131 POSITIVE REGULATION OF DEFENSE RESPONSE 9 364 3.3e-08 1.172e-06
132 REGULATION OF EPITHELIAL CELL MIGRATION 7 166 3.539e-08 1.248e-06
133 REGULATION OF CELL SUBSTRATE ADHESION 7 173 4.703e-08 1.645e-06
134 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 16 1672 4.801e-08 1.667e-06
135 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 9 381 4.88e-08 1.682e-06
136 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 6 103 5.363e-08 1.835e-06
137 REGULATION OF PROTEIN MODIFICATION PROCESS 16 1710 6.577e-08 2.234e-06
138 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 8 282 7.358e-08 2.481e-06
139 NEGATIVE REGULATION OF CELL DEATH 12 872 7.908e-08 2.647e-06
140 ENDOTHELIAL CELL MIGRATION 5 57 9.581e-08 3.184e-06
141 REGULATION OF RESPONSE TO WOUNDING 9 413 9.71e-08 3.204e-06
142 LEUKOCYTE ACTIVATION 9 414 9.912e-08 3.225e-06
143 REGULATION OF ENDOTHELIAL CELL MIGRATION 6 114 9.844e-08 3.225e-06
144 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 7 195 1.068e-07 3.426e-06
145 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 8 296 1.068e-07 3.426e-06
146 RESPONSE TO WOUNDING 10 563 1.143e-07 3.618e-06
147 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 5 59 1.142e-07 3.618e-06
148 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 23 1.181e-07 3.714e-06
149 REGULATION OF PROTEIN TARGETING 8 307 1.412e-07 4.41e-06
150 RESPONSE TO EXTERNAL STIMULUS 16 1821 1.578e-07 4.894e-06
151 POSITIVE REGULATION OF MAP KINASE ACTIVITY 7 207 1.604e-07 4.943e-06
152 INOSITOL LIPID MEDIATED SIGNALING 6 124 1.624e-07 4.973e-06
153 POSITIVE REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 4 25 1.683e-07 5.118e-06
154 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 16 1848 1.934e-07 5.842e-06
155 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 6 128 1.961e-07 5.888e-06
156 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 5 67 2.178e-07 6.455e-06
157 SINGLE ORGANISM CATABOLIC PROCESS 12 957 2.169e-07 6.455e-06
158 TAXIS 9 464 2.601e-07 7.661e-06
159 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 10 616 2.629e-07 7.693e-06
160 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 6 138 3.062e-07 8.905e-06
161 LYMPHOCYTE ACTIVATION 8 342 3.216e-07 9.293e-06
162 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 9 482 3.582e-07 1.023e-05
163 REGULATION OF VASCULATURE DEVELOPMENT 7 233 3.577e-07 1.023e-05
164 REGULATION OF CELL ACTIVATION 9 484 3.709e-07 1.048e-05
165 POSITIVE REGULATION OF CELL PROLIFERATION 11 814 3.717e-07 1.048e-05
166 RESPONSE TO ENDOGENOUS STIMULUS 14 1450 4.02e-07 1.127e-05
167 POSITIVE REGULATION OF CELL DIFFERENTIATION 11 823 4.147e-07 1.155e-05
168 RESPONSE TO ABIOTIC STIMULUS 12 1024 4.486e-07 1.242e-05
169 PEPTIDYL SERINE MODIFICATION 6 148 4.627e-07 1.269e-05
170 VESICLE MEDIATED TRANSPORT 13 1239 4.636e-07 1.269e-05
171 ENDOCYTOSIS 9 509 5.654e-07 1.538e-05
172 POSITIVE REGULATION OF CELL ADHESION 8 376 6.586e-07 1.782e-05
173 TISSUE MIGRATION 5 84 6.791e-07 1.827e-05
174 POSITIVE REGULATION OF CATALYTIC ACTIVITY 14 1518 7.013e-07 1.875e-05
175 REGULATION OF CELL CELL ADHESION 8 380 7.132e-07 1.896e-05
176 REGULATION OF CELL MATRIX ADHESION 5 90 9.584e-07 2.534e-05
177 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 4 39 1.072e-06 2.819e-05
178 REGULATION OF CELL MORPHOGENESIS 9 552 1.11e-06 2.901e-05
179 POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE 6 172 1.117e-06 2.903e-05
180 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 3 11 1.209e-06 3.126e-05
181 REPRODUCTIVE SYSTEM DEVELOPMENT 8 408 1.216e-06 3.126e-05
182 MYELOID LEUKOCYTE DIFFERENTIATION 5 96 1.321e-06 3.338e-05
183 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 11 926 1.327e-06 3.338e-05
184 ICOSANOID METABOLIC PROCESS 5 96 1.321e-06 3.338e-05
185 FATTY ACID DERIVATIVE METABOLIC PROCESS 5 96 1.321e-06 3.338e-05
186 POSITIVE REGULATION OF GLUCOSE TRANSPORT 4 42 1.453e-06 3.635e-05
187 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 289 1.516e-06 3.773e-05
188 REGULATION OF GLUCOSE TRANSPORT 5 100 1.618e-06 3.983e-05
189 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 3 12 1.61e-06 3.983e-05
190 REGULATION OF DEFENSE RESPONSE 10 759 1.761e-06 4.312e-05
191 MODULATION OF SYNAPTIC TRANSMISSION 7 301 1.987e-06 4.84e-05
192 REGULATION OF CELLULAR COMPONENT MOVEMENT 10 771 2.027e-06 4.913e-05
193 ICOSANOID BIOSYNTHETIC PROCESS 4 46 2.106e-06 5.052e-05
194 FATTY ACID DERIVATIVE BIOSYNTHETIC PROCESS 4 46 2.106e-06 5.052e-05
195 REGULATION OF HOMOTYPIC CELL CELL ADHESION 7 307 2.264e-06 5.385e-05
196 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 9 602 2.268e-06 5.385e-05
197 REGULATION OF MUSCLE SYSTEM PROCESS 6 195 2.317e-06 5.472e-05
198 REGULATION OF HOMEOSTATIC PROCESS 8 447 2.401e-06 5.642e-05
199 REGULATION OF MAP KINASE ACTIVITY 7 319 2.918e-06 6.788e-05
200 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 1004 2.915e-06 6.788e-05
201 REGULATION OF ADHERENS JUNCTION ORGANIZATION 4 50 2.956e-06 6.818e-05
202 POSITIVE REGULATION OF INFLAMMATORY RESPONSE 5 113 2.96e-06 6.818e-05
203 REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 4 51 3.202e-06 7.34e-05
204 CYTOKINE PRODUCTION 5 120 3.978e-06 9.073e-05
205 B CELL RECEPTOR SIGNALING PATHWAY 4 54 4.035e-06 9.159e-05
206 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 7 337 4.189e-06 9.462e-05
207 REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 3 17 4.943e-06 0.00011
208 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 3 17 4.943e-06 0.00011
209 NEGATIVE REGULATION OF ANOIKIS 3 17 4.943e-06 0.00011
210 CELLULAR HOMEOSTASIS 9 676 5.834e-06 0.0001293
211 OVULATION 3 18 5.923e-06 0.0001294
212 CELLULAR RESPONSE TO NITROGEN COMPOUND 8 505 5.904e-06 0.0001294
213 MAST CELL MEDIATED IMMUNITY 3 18 5.923e-06 0.0001294
214 REGULATION OF GLUCOSE IMPORT 4 60 6.169e-06 0.000134
215 CHEMICAL HOMEOSTASIS 10 874 6.191e-06 0.000134
216 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 6 232 6.303e-06 0.0001358
217 CELLULAR RESPONSE TO STRESS 13 1565 6.349e-06 0.0001361
218 MUSCLE CELL DIFFERENTIATION 6 237 7.121e-06 0.000152
219 CIRCULATORY SYSTEM PROCESS 7 366 7.193e-06 0.0001528
220 REGULATION OF ERK1 AND ERK2 CASCADE 6 238 7.294e-06 0.0001543
221 RESPONSE TO HORMONE 10 893 7.482e-06 0.0001575
222 POSITIVE REGULATION OF CYTOKINE PRODUCTION 7 370 7.721e-06 0.0001618
223 PLACENTA DEVELOPMENT 5 138 7.881e-06 0.0001644
224 RESPONSE TO BACTERIUM 8 528 8.175e-06 0.0001698
225 NON CANONICAL WNT SIGNALING PATHWAY 5 140 8.453e-06 0.0001748
226 MAST CELL ACTIVATION 3 21 9.614e-06 0.0001979
227 REGULATION OF CELL JUNCTION ASSEMBLY 4 68 1.018e-05 0.0002087
228 CELLULAR RESPONSE TO INSULIN STIMULUS 5 146 1.037e-05 0.0002106
229 T CELL RECEPTOR SIGNALING PATHWAY 5 146 1.037e-05 0.0002106
230 REGULATION OF PEPTIDE TRANSPORT 6 256 1.105e-05 0.0002236
231 REGULATION OF CELL PROJECTION ORGANIZATION 8 558 1.222e-05 0.0002461
232 LYSOSOME LOCALIZATION 3 23 1.277e-05 0.000256
233 REGULATION OF CYTOKINE PRODUCTION 8 563 1.303e-05 0.0002602
234 AMEBOIDAL TYPE CELL MIGRATION 5 154 1.343e-05 0.0002658
235 REGULATION OF ORGANELLE ORGANIZATION 11 1178 1.34e-05 0.0002658
236 RESPONSE TO PEPTIDE 7 404 1.366e-05 0.0002682
237 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 7 404 1.366e-05 0.0002682
238 CELL DEVELOPMENT 12 1426 1.409e-05 0.0002755
239 CELLULAR CHEMICAL HOMEOSTASIS 8 570 1.425e-05 0.0002774
240 REGULATION OF ANOIKIS 3 24 1.457e-05 0.0002825
241 CELLULAR GLUCOSE HOMEOSTASIS 4 75 1.505e-05 0.0002905
242 MULTICELLULAR ORGANISMAL HOMEOSTASIS 6 272 1.559e-05 0.0002997
243 CELLULAR RESPONSE TO PEPTIDE 6 274 1.625e-05 0.0003111
244 POSITIVE REGULATION OF RESPONSE TO WOUNDING 5 162 1.715e-05 0.0003271
245 LYMPHOCYTE COSTIMULATION 4 78 1.758e-05 0.0003339
246 VASCULAR PROCESS IN CIRCULATORY SYSTEM 5 163 1.767e-05 0.0003342
247 INSULIN RECEPTOR SIGNALING PATHWAY 4 80 1.944e-05 0.0003662
248 RESPONSE TO CARBOHYDRATE 5 168 2.044e-05 0.0003819
249 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 4 81 2.042e-05 0.0003819
250 RESPONSE TO LITHIUM ION 3 27 2.097e-05 0.0003902
251 POSITIVE REGULATION OF CELL DEATH 8 605 2.188e-05 0.0004057
252 TISSUE HOMEOSTASIS 5 171 2.225e-05 0.0004109
253 STRIATED MUSCLE CELL DIFFERENTIATION 5 173 2.353e-05 0.0004306
254 SMALL MOLECULE METABOLIC PROCESS 13 1767 2.36e-05 0.0004306
255 POSITIVE REGULATION OF ACUTE INFLAMMATORY RESPONSE 3 28 2.345e-05 0.0004306
256 REGULATION OF INFLAMMATORY RESPONSE 6 294 2.417e-05 0.0004394
257 FATTY ACID METABOLIC PROCESS 6 296 2.511e-05 0.0004546
258 TISSUE DEVELOPMENT 12 1518 2.638e-05 0.0004758
259 LEUKOCYTE DEGRANULATION 3 30 2.898e-05 0.0005187
260 CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 3 30 2.898e-05 0.0005187
261 SINGLE ORGANISM CELL ADHESION 7 459 3.101e-05 0.0005528
262 REPRODUCTION 11 1297 3.287e-05 0.0005838
263 PEPTIDYL AMINO ACID MODIFICATION 9 841 3.325e-05 0.0005883
264 POSITIVE REGULATION OF LIPID KINASE ACTIVITY 3 32 3.531e-05 0.0006223
265 MYELOID CELL DIFFERENTIATION 5 189 3.596e-05 0.0006307
266 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 470 3.606e-05 0.0006307
267 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 6 321 3.954e-05 0.000689
268 FEMALE GAMETE GENERATION 4 96 3.99e-05 0.0006927
269 RESPONSE TO INORGANIC SUBSTANCE 7 479 4.067e-05 0.0007035
270 RESPONSE TO FLUID SHEAR STRESS 3 34 4.248e-05 0.0007321
271 POSITIVE REGULATION OF CELL SUBSTRATE ADHESION 4 99 4.502e-05 0.000773
272 RESPONSE TO INSULIN 5 205 5.296e-05 0.0009059
273 REGULATION OF CALCIUM ION TRANSPORT 5 209 5.805e-05 0.0009857
274 REGULATION OF SYSTEM PROCESS 7 507 5.826e-05 0.0009857
275 LYMPHOCYTE DIFFERENTIATION 5 209 5.805e-05 0.0009857
276 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 4 106 5.882e-05 0.0009915
277 REGULATION OF CELL ADHESION MEDIATED BY INTEGRIN 3 39 6.443e-05 0.001078
278 PEPTIDYL TYROSINE AUTOPHOSPHORYLATION 3 39 6.443e-05 0.001078
279 WNT SIGNALING PATHWAY 6 351 6.493e-05 0.001083
280 UNSATURATED FATTY ACID METABOLIC PROCESS 4 109 6.558e-05 0.00109
281 NEUROGENESIS 11 1402 6.706e-05 0.00111
282 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 5 216 6.785e-05 0.00112
283 ALCOHOL BIOSYNTHETIC PROCESS 4 111 7.04e-05 0.001157
284 CELLULAR MODIFIED AMINO ACID METABOLIC PROCESS 5 220 7.4e-05 0.001212
285 MYELOID CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 3 41 7.495e-05 0.001224
286 REGULATION OF APOPTOTIC SIGNALING PATHWAY 6 363 7.817e-05 0.001272
287 NEGATIVE REGULATION OF CELL ADHESION 5 223 7.889e-05 0.001279
288 POSITIVE REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 3 42 8.06e-05 0.001293
289 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 6 365 8.058e-05 0.001293
290 REGULATED EXOCYTOSIS 5 224 8.057e-05 0.001293
291 REGULATION OF SUBSTRATE ADHESION DEPENDENT CELL SPREADING 3 43 8.652e-05 0.001379
292 MYELOID LEUKOCYTE MEDIATED IMMUNITY 3 43 8.652e-05 0.001379
293 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 5 228 8.758e-05 0.001391
294 NEGATIVE REGULATION OF CELL COMMUNICATION 10 1192 8.919e-05 0.001412
295 REGULATION OF PROTEIN KINASE B SIGNALING 4 121 9.844e-05 0.001553
296 SPROUTING ANGIOGENESIS 3 45 9.921e-05 0.00156
297 REGULATION OF NEURON DIFFERENTIATION 7 554 0.0001015 0.001591
298 REGULATION OF PROTEIN SECRETION 6 389 0.0001143 0.001784
299 REGULATION OF CELLULAR COMPONENT BIOGENESIS 8 767 0.0001166 0.001809
300 DEFENSE RESPONSE 10 1231 0.0001166 0.001809
301 CATABOLIC PROCESS 12 1773 0.0001205 0.001862
302 MUSCLE CELL DEVELOPMENT 4 128 0.0001224 0.001885
303 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 7 573 0.0001252 0.001923
304 CELL DEATH 9 1001 0.0001276 0.00195
305 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 12 1784 0.0001278 0.00195
306 SYSTEM PROCESS 12 1785 0.0001285 0.001954
307 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 4 131 0.0001338 0.002028
308 ARACHIDONIC ACID METABOLIC PROCESS 3 50 0.0001361 0.002056
309 B CELL ACTIVATION 4 132 0.0001378 0.002075
310 SECRETION 7 588 0.0001469 0.002205
311 REGULATION OF NEURON PROJECTION DEVELOPMENT 6 408 0.0001482 0.002211
312 LEUKOCYTE CELL CELL ADHESION 5 255 0.000148 0.002211
313 CELLULAR RESPONSE TO RADIATION 4 137 0.000159 0.002364
314 RESPONSE TO ORGANOPHOSPHORUS 4 139 0.0001681 0.002484
315 CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 4 139 0.0001681 0.002484
316 REGULATION OF SYNAPTIC PLASTICITY 4 140 0.0001728 0.002545
317 CELL CELL ADHESION 7 608 0.0001805 0.00265
318 MUSCLE STRUCTURE DEVELOPMENT 6 432 0.0002021 0.002957
319 POSITIVE REGULATION OF ENDOTHELIAL CELL CHEMOTAXIS 2 11 0.0002121 0.003046
320 CHEMICAL HOMEOSTASIS WITHIN A TISSUE 2 11 0.0002121 0.003046
321 REGULATION OF FEVER GENERATION 2 11 0.0002121 0.003046
322 CYCLOOXYGENASE PATHWAY 2 11 0.0002121 0.003046
323 REGULATION OF CELL DEVELOPMENT 8 836 0.0002108 0.003046
324 UNSATURATED FATTY ACID BIOSYNTHETIC PROCESS 3 58 0.0002119 0.003046
325 VASCULOGENESIS 3 59 0.0002229 0.003192
326 ACTIVATION OF PROTEIN KINASE ACTIVITY 5 279 0.0002249 0.00321
327 MATERNAL PROCESS INVOLVED IN FEMALE PREGNANCY 3 60 0.0002343 0.003334
328 POSITIVE REGULATION OF CYCLASE ACTIVITY 3 61 0.0002461 0.003491
329 ANATOMICAL STRUCTURE HOMEOSTASIS 5 285 0.0002481 0.003509
330 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 4 154 0.000249 0.003511
331 REGULATION OF BROWN FAT CELL DIFFERENTIATION 2 12 0.0002542 0.003573
332 INFLAMMATORY RESPONSE 6 454 0.0002641 0.003701
333 REGULATION OF MUSCLE ADAPTATION 3 63 0.0002708 0.003784
334 RESPONSE TO PURINE CONTAINING COMPOUND 4 158 0.0002746 0.003825
335 CENTRAL NERVOUS SYSTEM DEVELOPMENT 8 872 0.0002807 0.003899
336 NEURON DIFFERENTIATION 8 874 0.0002851 0.003948
337 REGULATION OF VESICLE MEDIATED TRANSPORT 6 462 0.00029 0.004004
338 LIPOXYGENASE PATHWAY 2 13 3e-04 0.004118
339 LYMPH VESSEL MORPHOGENESIS 2 13 3e-04 0.004118
340 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 4 162 0.000302 0.004133
341 HEART DEVELOPMENT 6 466 0.0003037 0.004144
342 CELLULAR RESPONSE TO UV 3 66 0.0003108 0.004216
343 POSITIVE REGULATION OF LIPID BIOSYNTHETIC PROCESS 3 66 0.0003108 0.004216
344 RESPONSE TO BIOTIC STIMULUS 8 886 0.0003126 0.004228
345 RESPONSE TO LIPID 8 888 0.0003174 0.004281
346 ESTABLISHMENT OF LOCALIZATION IN CELL 11 1676 0.0003272 0.004401
347 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 303 0.000329 0.004412
348 RESPONSE TO GROWTH FACTOR 6 475 0.0003363 0.004497
349 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 4 167 0.000339 0.004499
350 MORPHOGENESIS OF A BRANCHING STRUCTURE 4 167 0.000339 0.004499
351 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 3 68 0.0003394 0.004499
352 VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING PATHWAY 2 14 0.0003496 0.004506
353 ARACHIDONIC ACID SECRETION 2 14 0.0003496 0.004506
354 REGULATION OF FIBROBLAST APOPTOTIC PROCESS 2 14 0.0003496 0.004506
355 ESTABLISHMENT OF NUCLEUS LOCALIZATION 2 14 0.0003496 0.004506
356 T CELL MIGRATION 2 14 0.0003496 0.004506
357 CELLULAR COMPONENT MORPHOGENESIS 8 900 0.0003474 0.004506
358 CARDIOLIPIN METABOLIC PROCESS 2 14 0.0003496 0.004506
359 REGULATION OF PROTEIN KINASE C SIGNALING 2 14 0.0003496 0.004506
360 POSITIVE REGULATION OF SPROUTING ANGIOGENESIS 2 14 0.0003496 0.004506
361 ARACHIDONATE TRANSPORT 2 14 0.0003496 0.004506
362 CELL PROJECTION ORGANIZATION 8 902 0.0003526 0.004532
363 GLUCOSE HOMEOSTASIS 4 170 0.0003627 0.004636
364 CARBOHYDRATE HOMEOSTASIS 4 170 0.0003627 0.004636
365 EXOCYTOSIS 5 310 0.0003653 0.004657
366 POSITIVE REGULATION OF CELL ACTIVATION 5 311 0.0003708 0.004702
367 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 4 171 0.0003708 0.004702
368 CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 2 15 0.0004028 0.005049
369 REGULATION OF HEAT GENERATION 2 15 0.0004028 0.005049
370 NEGATIVE REGULATION OF DENDRITE MORPHOGENESIS 2 15 0.0004028 0.005049
371 HOMEOSTASIS OF NUMBER OF CELLS 4 175 0.0004048 0.005049
372 RESPIRATORY BURST 2 15 0.0004028 0.005049
373 ORGANIC HYDROXY COMPOUND BIOSYNTHETIC PROCESS 4 175 0.0004048 0.005049
374 RESPONSE TO CORTICOSTEROID 4 176 0.0004136 0.005146
375 REGULATION OF SECRETION 7 699 0.0004214 0.005229
376 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 3 74 0.0004354 0.005374
377 REGULATION OF ACUTE INFLAMMATORY RESPONSE 3 74 0.0004354 0.005374
378 REGULATION OF METAL ION TRANSPORT 5 325 0.0004534 0.005566
379 GRANULOCYTE MIGRATION 3 75 0.0004529 0.005566
380 MONOCARBOXYLIC ACID METABOLIC PROCESS 6 503 0.000456 0.005584
381 REGULATION OF EARLY ENDOSOME TO LATE ENDOSOME TRANSPORT 2 16 0.0004598 0.005586
382 HEAD DEVELOPMENT 7 709 0.0004589 0.005586
383 POSITIVE REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 16 0.0004598 0.005586
384 RESPONSE TO CYTOKINE 7 714 0.0004786 0.0058
385 RESPONSE TO METAL ION 5 333 0.0005064 0.006105
386 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 513 0.000506 0.006105
387 REGULATION OF RECEPTOR MEDIATED ENDOCYTOSIS 3 78 0.0005081 0.00611
388 PEPTIDYL TYROSINE MODIFICATION 4 186 0.0005095 0.00611
389 REGULATION OF CHROMATIN BINDING 2 17 0.0005204 0.006193
390 POSITIVE REGULATION OF FATTY ACID BIOSYNTHETIC PROCESS 2 17 0.0005204 0.006193
391 REGULATION OF ENDOTHELIAL CELL CHEMOTAXIS 2 17 0.0005204 0.006193
392 PROTEIN DEPHOSPHORYLATION 4 190 0.000552 0.006552
393 RESPONSE TO REACTIVE OXYGEN SPECIES 4 191 0.000563 0.006665
394 PROTEIN AUTOPHOSPHORYLATION 4 192 0.0005741 0.00678
395 REGULATION OF MITOCHONDRIAL DEPOLARIZATION 2 18 0.0005848 0.006888
396 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 3 84 0.0006312 0.00741
397 RESPIRATORY SYSTEM DEVELOPMENT 4 197 0.0006323 0.00741
398 PROSTAGLANDIN BIOSYNTHETIC PROCESS 2 19 0.0006527 0.007451
399 CELLULAR RESPONSE TO FLUID SHEAR STRESS 2 19 0.0006527 0.007451
400 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 7 750 0.0006416 0.007451
401 REGULATION OF CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 2 19 0.0006527 0.007451
402 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 5 352 0.0006511 0.007451
403 EPHRIN RECEPTOR SIGNALING PATHWAY 3 85 0.0006534 0.007451
404 REGULATION OF MYOBLAST FUSION 2 19 0.0006527 0.007451
405 MACROPHAGE DIFFERENTIATION 2 19 0.0006527 0.007451
406 HEART PROCESS 3 85 0.0006534 0.007451
407 RESPONSE TO OXIDATIVE STRESS 5 352 0.0006511 0.007451
408 PROSTANOID BIOSYNTHETIC PROCESS 2 19 0.0006527 0.007451
409 NEURON PROJECTION DEVELOPMENT 6 545 0.0006954 0.007911
410 EMBRYONIC HEMOPOIESIS 2 20 0.0007243 0.008044
411 ICOSANOID TRANSPORT 2 20 0.0007243 0.008044
412 LONG CHAIN FATTY ACID METABOLIC PROCESS 3 88 0.0007229 0.008044
413 CELLULAR RESPONSE TO GROWTH HORMONE STIMULUS 2 20 0.0007243 0.008044
414 OVULATION CYCLE PROCESS 3 88 0.0007229 0.008044
415 NUCLEUS LOCALIZATION 2 20 0.0007243 0.008044
416 FATTY ACID DERIVATIVE TRANSPORT 2 20 0.0007243 0.008044
417 ACTIVATION OF INNATE IMMUNE RESPONSE 4 204 0.0007205 0.008044
418 LYMPH VESSEL DEVELOPMENT 2 20 0.0007243 0.008044
419 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 3 88 0.0007229 0.008044
420 NEURON PROJECTION GUIDANCE 4 205 0.0007338 0.008129
421 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 8 1008 0.0007374 0.00814
422 MULTICELLULAR ORGANISM REPRODUCTION 7 768 0.0007382 0.00814
423 CELLULAR RESPONSE TO HORMONE STIMULUS 6 552 0.0007433 0.008157
424 TUBE DEVELOPMENT 6 552 0.0007433 0.008157
425 REGULATION OF PEPTIDE SECRETION 4 209 0.0007887 0.008635
426 DENDRITIC CELL MIGRATION 2 21 0.0007996 0.008652
427 CELLULAR RESPONSE TO LIGHT STIMULUS 3 91 0.000797 0.008652
428 DECIDUALIZATION 2 21 0.0007996 0.008652
429 POSITIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 2 21 0.0007996 0.008652
430 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 5 368 0.0007954 0.008652
431 POSITIVE REGULATION OF SECRETION 5 370 0.000815 0.008799
432 POSITIVE REGULATION OF PROTEIN SECRETION 4 211 0.0008172 0.008802
433 MULTI MULTICELLULAR ORGANISM PROCESS 4 213 0.0008464 0.009095
434 POSITIVE REGULATION OF BLOOD CIRCULATION 3 93 0.000849 0.009102
435 BIOLOGICAL ADHESION 8 1032 0.00086 0.0092
436 NEGATIVE REGULATION OF MUSCLE CONTRACTION 2 22 0.0008784 0.00931
437 POSITIVE REGULATION OF MUSCLE HYPERTROPHY 2 22 0.0008784 0.00931
438 POSITIVE REGULATION OF PROTEIN AUTOPHOSPHORYLATION 2 22 0.0008784 0.00931
439 POSITIVE REGULATION OF CARDIAC MUSCLE HYPERTROPHY 2 22 0.0008784 0.00931
440 REGULATION OF MITOCHONDRION ORGANIZATION 4 218 0.0009227 0.009757
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 17 842 1.248e-13 8.67e-11
2 PHOSPHOLIPASE A2 ACTIVITY 7 31 1.866e-13 8.67e-11
3 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 17 992 1.753e-12 5.427e-10
4 PHOSPHOLIPASE ACTIVITY 8 94 1.194e-11 2.774e-09
5 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 70 8.042e-11 1.245e-08
6 LIPASE ACTIVITY 8 117 7.081e-11 1.245e-08
7 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 6 43 2.496e-10 3.313e-08
8 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 6 51 7.288e-10 8.463e-08
9 HYDROLASE ACTIVITY ACTING ON ESTER BONDS 13 739 1.031e-09 1.065e-07
10 RIBONUCLEOTIDE BINDING 18 1860 3.836e-09 3.564e-07
11 CARBOXYLIC ESTER HYDROLASE ACTIVITY 7 135 8.453e-09 7.139e-07
12 PROTEIN KINASE ACTIVITY 11 640 3.285e-08 2.543e-06
13 CALMODULIN BINDING 7 179 5.943e-08 4.247e-06
14 ENZYME BINDING 16 1737 8.186e-08 5.432e-06
15 KINASE REGULATOR ACTIVITY 6 186 1.761e-06 0.0001091
16 KINASE BINDING 9 606 2.395e-06 0.0001309
17 PROTEIN SERINE THREONINE KINASE ACTIVITY 8 445 2.322e-06 0.0001309
18 PROTEIN PHOSPHATASE BINDING 5 120 3.978e-06 0.0001993
19 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 3 16 4.076e-06 0.0001993
20 ADENYL NUCLEOTIDE BINDING 13 1514 4.41e-06 0.0002049
21 PHOSPHATASE BINDING 5 162 1.715e-05 0.0007587
22 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 5 178 2.698e-05 0.001139
23 CALCIUM ION BINDING 8 697 5.981e-05 0.002416
24 PHOSPHORIC ESTER HYDROLASE ACTIVITY 6 368 8.429e-05 0.003263
25 PHOSPHATASE ACTIVITY 5 275 0.0002103 0.007578
26 INSULIN RECEPTOR SUBSTRATE BINDING 2 11 0.0002121 0.007578
27 CALCIUM DEPENDENT PROTEIN KINASE ACTIVITY 2 12 0.0002542 0.008433
28 MAP KINASE KINASE ACTIVITY 2 12 0.0002542 0.008433
29 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 3 64 0.0002837 0.009089
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 5.591e-15 3.265e-12
2 EXTRINSIC COMPONENT OF MEMBRANE 10 252 5.132e-11 1.499e-08
3 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 7 237 4.013e-07 7.812e-05
4 MAST CELL GRANULE 3 21 9.614e-06 0.001404
5 CATALYTIC COMPLEX 10 1038 2.766e-05 0.00323

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04370_VEGF_signaling_pathway 40 76 4.793e-103 8.628e-101
2 hsa04664_Fc_epsilon_RI_signaling_pathway 24 79 2.565e-49 2.309e-47
3 hsa04662_B_cell_receptor_signaling_pathway 22 75 1.516e-44 9.096e-43
4 hsa04660_T_cell_receptor_signaling_pathway 22 108 1.388e-40 6.247e-39
5 hsa04650_Natural_killer_cell_mediated_cytotoxicity 22 136 3.565e-38 1.283e-36
6 hsa04014_Ras_signaling_pathway 23 236 1.122e-34 3.365e-33
7 hsa04010_MAPK_signaling_pathway 23 268 2.332e-33 5.996e-32
8 hsa04012_ErbB_signaling_pathway 16 87 2.206e-28 4.964e-27
9 hsa04666_Fc_gamma_R.mediated_phagocytosis 16 95 1.019e-27 2.037e-26
10 hsa04380_Osteoclast_differentiation 17 128 1.321e-27 2.378e-26
11 hsa04912_GnRH_signaling_pathway 16 101 2.932e-27 4.798e-26
12 hsa04510_Focal_adhesion 17 200 3.635e-24 5.452e-23
13 hsa04722_Neurotrophin_signaling_pathway 15 127 1.65e-23 2.285e-22
14 hsa04670_Leukocyte_transendothelial_migration 14 117 5.032e-22 6.47e-21
15 hsa04730_Long.term_depression 12 70 6.469e-21 7.763e-20
16 hsa04914_Progesterone.mediated_oocyte_maturation 12 87 1.055e-19 1.187e-18
17 hsa04210_Apoptosis 12 89 1.408e-19 1.491e-18
18 hsa04360_Axon_guidance 13 130 2.073e-19 2.073e-18
19 hsa04960_Aldosterone.regulated_sodium_reabsorption 10 42 4.241e-19 4.017e-18
20 hsa04062_Chemokine_signaling_pathway 14 189 5.208e-19 4.688e-18
21 hsa04151_PI3K_AKT_signaling_pathway 16 351 2.471e-18 2.118e-17
22 hsa04620_Toll.like_receptor_signaling_pathway 11 102 7.13e-17 5.834e-16
23 hsa04973_Carbohydrate_digestion_and_absorption 9 44 1.311e-16 1.026e-15
24 hsa04810_Regulation_of_actin_cytoskeleton 13 214 1.558e-16 1.169e-15
25 hsa04070_Phosphatidylinositol_signaling_system 10 78 3.452e-16 2.486e-15
26 hsa04150_mTOR_signaling_pathway 9 52 6.726e-16 4.657e-15
27 hsa04910_Insulin_signaling_pathway 11 138 2.194e-15 1.463e-14
28 hsa00592_alpha.Linolenic_acid_metabolism 7 20 5.591e-15 3.594e-14
29 hsa04310_Wnt_signaling_pathway 11 151 6.018e-15 3.735e-14
30 hsa04720_Long.term_potentiation 9 70 1.159e-14 6.956e-14
31 hsa04270_Vascular_smooth_muscle_contraction 10 116 2.124e-14 1.234e-13
32 hsa00591_Linoleic_acid_metabolism 7 30 1.447e-13 8.14e-13
33 hsa00590_Arachidonic_acid_metabolism 8 59 2.501e-13 1.364e-12
34 hsa04972_Pancreatic_secretion 9 101 3.565e-13 1.887e-12
35 hsa00565_Ether_lipid_metabolism 7 36 5.883e-13 3.025e-12
36 hsa04975_Fat_digestion_and_absorption 7 46 3.718e-12 1.859e-11
37 hsa04020_Calcium_signaling_pathway 9 177 5.864e-11 2.853e-10
38 hsa00564_Glycerophospholipid_metabolism 7 80 2.101e-10 9.95e-10
39 hsa04630_Jak.STAT_signaling_pathway 8 155 6.763e-10 3.121e-09
40 hsa04530_Tight_junction 7 133 7.618e-09 3.428e-08
41 hsa04540_Gap_junction 6 90 2.38e-08 1.045e-07
42 hsa04916_Melanogenesis 5 101 1.7e-06 7.285e-06
43 hsa04114_Oocyte_meiosis 5 114 3.091e-06 1.294e-05
44 hsa00562_Inositol_phosphate_metabolism 4 57 5.018e-06 2.053e-05
45 hsa04520_Adherens_junction 3 73 0.0004183 0.001673
46 hsa04320_Dorso.ventral_axis_formation 2 25 0.001136 0.004447
47 hsa04621_NOD.like_receptor_signaling_pathway 2 59 0.00621 0.02378
48 hsa04144_Endocytosis 3 203 0.007724 0.02896
49 hsa04622_RIG.I.like_receptor_signaling_pathway 2 71 0.008884 0.03263
50 hsa04971_Gastric_acid_secretion 2 74 0.009619 0.03463
51 hsa04970_Salivary_secretion 2 89 0.01369 0.0483

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

CECR7

 hsa-miR-141-5p;hsa-miR-148a-5p;hsa-miR-16-2-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-24-3p;hsa-miR-26b-5p;hsa-miR-29a-5p;hsa-miR-29b-1-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-361-5p;hsa-miR-429;hsa-miR-491-5p;hsa-miR-502-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p 24 PRKCB Sponge network 0.551 0.56177 -0.289 0.6299 0.583
2

EMX2OS

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-424-5p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-502-5p;hsa-miR-505-3p;hsa-miR-577;hsa-miR-663b;hsa-miR-93-5p 25 AKT3 Sponge network 1.057 0.31716 0.457 0.53933 0.542
3

CECR7

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1275;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-362-5p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-502-5p;hsa-miR-93-5p 20 AKT3 Sponge network 0.551 0.56177 0.457 0.53933 0.508
4

EMX2OS

 hsa-miR-141-5p;hsa-miR-148a-5p;hsa-miR-16-2-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-26b-5p;hsa-miR-27a-3p;hsa-miR-29a-5p;hsa-miR-29b-1-5p;hsa-miR-30d-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-452-3p;hsa-miR-484;hsa-miR-502-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-7-5p 21 PRKCB Sponge network 1.057 0.31716 -0.289 0.6299 0.407
5

MEG3

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-577;hsa-miR-93-5p 12 AKT3 Sponge network 0.433 0.33816 0.457 0.53933 0.405
6

CECR7

 hsa-let-7f-1-3p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-32-3p;hsa-miR-335-5p;hsa-miR-582-3p;hsa-miR-590-3p;hsa-miR-590-5p 11 PIK3CA Sponge network 0.551 0.56177 0.023 0.97942 0.368
7

ZNF883

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-33a-3p 10 AKT3 Sponge network 0.913 0.16772 0.457 0.53933 0.3
8

MEG3

 hsa-miR-141-5p;hsa-miR-16-2-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-26b-5p;hsa-miR-29b-1-5p;hsa-miR-30d-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-429;hsa-miR-590-5p;hsa-miR-7-1-3p 14 PRKCB Sponge network 0.433 0.33816 -0.289 0.6299 0.266
9

EMX2OS

 hsa-let-7f-1-3p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-32-3p;hsa-miR-335-5p;hsa-miR-339-5p;hsa-miR-374b-5p;hsa-miR-576-5p;hsa-miR-582-3p;hsa-miR-590-3p 13 PIK3CA Sponge network 1.057 0.31716 0.023 0.97942 0.254

Quest ID: 1797cd9fd6fb36ffb53118975e5e7906