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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106b-5p AKT3 2.81 0 -3.33 1.0E-5 miRNATAP -0.41 1.0E-5 NA
2 hsa-miR-142-3p AKT3 4.35 0 -3.33 1.0E-5 miRanda -0.16 0.00934 NA
3 hsa-miR-15a-5p AKT3 2.05 0 -3.33 1.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.37 0.00021 NA
4 hsa-miR-15b-5p AKT3 3.32 0 -3.33 1.0E-5 miRNATAP -0.25 0.00571 NA
5 hsa-miR-16-5p AKT3 2.94 0 -3.33 1.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.31 0.00086 NA
6 hsa-miR-29b-3p AKT3 0.67 0.23406 -3.33 1.0E-5 miRNATAP -0.28 0.00031 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
7 hsa-miR-3065-5p AKT3 2.14 0.06094 -3.33 1.0E-5 mirMAP -0.22 0 NA
8 hsa-miR-362-3p AKT3 0.68 0.22615 -3.33 1.0E-5 miRanda -0.25 0.00124 NA
9 hsa-miR-501-3p AKT3 1.72 0.00759 -3.33 1.0E-5 miRNATAP -0.18 0.00733 NA
10 hsa-miR-93-5p AKT3 2.66 0 -3.33 1.0E-5 miRNATAP -0.33 0.00021 NA
11 hsa-miR-146b-5p BRAF 1.88 0.00074 0.87 0.02116 miRanda -0.1 0.0087 21874046; 26883911; 20406109; 21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF
12 hsa-miR-200b-3p CAB39 5.56 0 -0.04 0.90683 MirTarget; TargetScan -0.1 0.00021 NA
13 hsa-miR-155-5p CAB39L 2.81 7.0E-5 -2.97 0 miRNAWalker2 validate -0.24 0 NA
14 hsa-miR-33a-3p CAB39L 2.06 0.00156 -2.97 0 MirTarget -0.18 0.00143 NA
15 hsa-miR-342-3p CAB39L 1.31 0.02072 -2.97 0 miRanda -0.29 0 NA
16 hsa-miR-590-3p CAB39L 2.35 0 -2.97 0 miRanda -0.31 2.0E-5 NA
17 hsa-miR-590-5p CAB39L 1.51 0.00239 -2.97 0 miRanda -0.25 0.00067 NA
18 hsa-miR-101-3p DDIT4 -1.12 0.02009 0.48 0.49995 miRNAWalker2 validate; MirTarget; miRNATAP -0.23 0.00577 NA
19 hsa-miR-200b-3p DDIT4 5.56 0 0.48 0.49995 TargetScan -0.15 0.00841 NA
20 hsa-miR-30c-5p EIF4E 0.39 0.34861 -0.04 0.91192 mirMAP -0.13 0.00522 NA
21 hsa-miR-125a-5p EIF4EBP1 -1.32 0.00714 1.78 0.00058 miRNAWalker2 validate; MirTarget; miRanda; miRNATAP -0.19 0.00177 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression
22 hsa-miR-28-5p HIF1A -0.82 0.02212 0.73 0.1694 miRanda -0.25 0.00323 NA
23 hsa-let-7f-1-3p IGF1 1.62 0.00069 -4.48 0.00149 mirMAP -0.92 0 NA
24 hsa-miR-103a-2-5p IGF1 2.77 0.0003 -4.48 0.00149 mirMAP -0.61 0 NA
25 hsa-miR-130b-3p IGF1 3.92 0 -4.48 0.00149 MirTarget -0.48 0.00036 NA
26 hsa-miR-15b-3p IGF1 3.58 0 -4.48 0.00149 mirMAP -0.73 0 NA
27 hsa-miR-16-1-3p IGF1 2.83 0 -4.48 0.00149 mirMAP -0.81 0 NA
28 hsa-miR-19a-3p IGF1 2.17 0.00122 -4.48 0.00149 MirTarget -0.58 0 NA
29 hsa-miR-19b-1-5p IGF1 1.51 0.00147 -4.48 0.00149 mirMAP -1.02 0 NA
30 hsa-miR-19b-3p IGF1 1.68 0.00086 -4.48 0.00149 MirTarget -0.83 0 NA
31 hsa-miR-20a-3p IGF1 1.99 0.00062 -4.48 0.00149 mirMAP -0.77 0 NA
32 hsa-miR-27a-3p IGF1 1.76 0.00022 -4.48 0.00149 miRNAWalker2 validate; miRTarBase -1.1 0 NA
33 hsa-miR-301a-3p IGF1 1.99 0.00081 -4.48 0.00149 MirTarget -0.46 0.00055 NA
34 hsa-miR-32-3p IGF1 2.2 0.03928 -4.48 0.00149 mirMAP -0.55 3.0E-5 NA
35 hsa-miR-33a-3p IGF1 2.06 0.00156 -4.48 0.00149 MirTarget -0.4 0.00118 NA
36 hsa-miR-452-5p IGF1 2.45 0.00115 -4.48 0.00149 MirTarget; mirMAP -0.29 0.00626 NA
37 hsa-miR-486-5p IGF1 1.11 0.30929 -4.48 0.00149 PITA; miRNATAP -0.35 0 NA
38 hsa-miR-576-5p IGF1 1.3 0.00649 -4.48 0.00149 PITA; mirMAP; miRNATAP -0.69 4.0E-5 NA
39 hsa-miR-629-5p IGF1 1.57 0.01157 -4.48 0.00149 mirMAP -0.43 0.0009 NA
40 hsa-miR-940 IGF1 3.78 5.0E-5 -4.48 0.00149 MirTarget; PITA; miRNATAP -0.34 0.00113 NA
41 hsa-miR-148b-3p MAPK1 1.76 0 0.01 0.9644 mirMAP -0.14 0.00442 NA
42 hsa-miR-29b-2-5p MAPK1 -0.6 0.18954 0.01 0.9644 mirMAP -0.15 2.0E-5 NA
43 hsa-miR-29c-3p MAPK1 -0.41 0.52934 0.01 0.9644 mirMAP -0.12 0 NA
44 hsa-miR-30b-5p MAPK1 0.02 0.95322 0.01 0.9644 mirMAP -0.11 0.00754 NA
45 hsa-miR-30e-5p MAPK1 0.78 0.03467 0.01 0.9644 mirMAP -0.12 0.00886 NA
46 hsa-miR-3913-5p MAPK1 0.15 0.73484 0.01 0.9644 mirMAP -0.11 0.0044 NA
47 hsa-miR-2355-5p PDPK1 0.42 0.50215 0.31 0.47594 mirMAP -0.1 0.00842 NA
48 hsa-miR-331-3p PDPK1 2.61 0 0.31 0.47594 miRNAWalker2 validate -0.12 0.00928 NA
49 hsa-miR-335-5p PDPK1 0.17 0.8039 0.31 0.47594 mirMAP -0.12 0.0009 NA
50 hsa-miR-374a-3p PDPK1 0.47 0.30527 0.31 0.47594 mirMAP -0.23 2.0E-5 NA
51 hsa-miR-374b-5p PDPK1 -0.11 0.76489 0.31 0.47594 miRNATAP -0.2 0.00228 NA
52 hsa-miR-424-5p PDPK1 0.21 0.75371 0.31 0.47594 mirMAP -0.11 0.00322 NA
53 hsa-miR-505-3p PDPK1 0.59 0.22694 0.31 0.47594 mirMAP -0.16 0.00135 NA
54 hsa-miR-590-3p PDPK1 2.35 0 0.31 0.47594 miRanda; miRNATAP -0.15 0.00127 NA
55 hsa-miR-7-1-3p PDPK1 1.43 0.00471 0.31 0.47594 mirMAP -0.17 0.00048 NA
56 hsa-miR-708-3p PDPK1 0.78 0.29065 0.31 0.47594 miRNATAP -0.1 0.00176 NA
57 hsa-miR-34a-5p PGF 0.83 0.04775 0.03 0.97889 miRNATAP -0.47 0.00035 NA
58 hsa-miR-429 PGF 6.4 0 0.03 0.97889 miRNATAP -0.26 0.0002 NA
59 hsa-miR-148b-3p PIK3CA 1.76 0 0.51 0.24893 miRNAWalker2 validate -0.24 0.00148 NA
60 hsa-miR-186-5p PIK3CA 0.45 0.18545 0.51 0.24893 mirMAP -0.28 0.00023 NA
61 hsa-miR-29b-1-5p PIK3CA 0.34 0.59809 0.51 0.24893 mirMAP -0.12 0.00234 NA
62 hsa-miR-320b PIK3CA 0.2 0.72722 0.51 0.24893 miRanda -0.12 0.00551 NA
63 hsa-miR-335-5p PIK3CA 0.17 0.8039 0.51 0.24893 miRNAWalker2 validate -0.12 0.00088 NA
64 hsa-miR-338-5p PIK3CA -0.11 0.89468 0.51 0.24893 mirMAP -0.11 0.00047 NA
65 hsa-miR-339-5p PIK3CA 1.23 0.03075 0.51 0.24893 miRanda -0.14 0.00178 NA
66 hsa-miR-501-5p PIK3CA 1.04 0.07772 0.51 0.24893 mirMAP -0.12 0.00474 NA
67 hsa-miR-130a-3p PIK3CB 0.18 0.75775 0.9 0.01258 miRNATAP -0.12 0.00106 NA
68 hsa-miR-19b-3p PIK3CB 1.68 0.00086 0.9 0.01258 miRNATAP -0.11 0.00639 NA
69 hsa-miR-1468-5p PIK3CD -1.63 0.00779 0.06 0.92656 MirTarget -0.15 0.0056 NA
70 hsa-miR-199a-5p PIK3CD -1.25 0.07478 0.06 0.92656 MirTarget; PITA; miRanda; miRNATAP -0.16 0.00086 NA
71 hsa-miR-30d-5p PIK3CD 0.3 0.38019 0.06 0.92656 MirTarget; miRNATAP -0.27 0.00723 NA
72 hsa-miR-3913-5p PIK3CD 0.15 0.73484 0.06 0.92656 mirMAP -0.26 0.00117 NA
73 hsa-miR-335-3p PIK3CG 1.2 0.09389 -0.16 0.84867 mirMAP -0.29 1.0E-5 NA
74 hsa-miR-16-2-3p PIK3R1 3.8 0 -1.85 0.01274 MirTarget -0.22 0.0055 NA
75 hsa-miR-16-5p PIK3R1 2.94 0 -1.85 0.01274 MirTarget -0.23 0.00941 NA
76 hsa-miR-17-5p PIK3R1 2.33 2.0E-5 -1.85 0.01274 MirTarget; TargetScan; miRNATAP -0.26 0.00056 NA
77 hsa-miR-200c-3p PIK3R1 6.47 0 -1.85 0.01274 mirMAP -0.21 0.00097 NA
78 hsa-miR-29b-3p PIK3R1 0.67 0.23406 -1.85 0.01274 MirTarget; miRNATAP -0.23 0.00248 NA
79 hsa-miR-3065-5p PIK3R1 2.14 0.06094 -1.85 0.01274 MirTarget; mirMAP; miRNATAP -0.14 0.003 NA
80 hsa-miR-320c PIK3R1 -0.11 0.854 -1.85 0.01274 miRNATAP -0.24 0.00153 NA
81 hsa-miR-330-3p PIK3R1 2.49 0.00013 -1.85 0.01274 MirTarget; PITA; miRNATAP -0.22 0.00056 NA
82 hsa-miR-335-3p PIK3R1 1.2 0.09389 -1.85 0.01274 mirMAP -0.19 0.00155 NA
83 hsa-miR-338-5p PIK3R1 -0.11 0.89468 -1.85 0.01274 PITA -0.15 0.00415 NA
84 hsa-miR-582-5p PIK3R1 0.69 0.44776 -1.85 0.01274 mirMAP -0.17 0.00029 NA
85 hsa-miR-584-5p PIK3R1 1.18 0.20286 -1.85 0.01274 mirMAP -0.26 0 NA
86 hsa-miR-590-5p PIK3R1 1.51 0.00239 -1.85 0.01274 MirTarget; PITA; miRanda; miRNATAP -0.3 0.00045 NA
87 hsa-miR-629-3p PIK3R1 3.48 0 -1.85 0.01274 MirTarget -0.21 0.00106 NA
88 hsa-miR-1271-5p PIK3R3 0.21 0.74254 -0.03 0.95933 mirMAP -0.15 0.003 NA
89 hsa-miR-18a-3p PIK3R3 3.65 0 -0.03 0.95933 miRNAWalker2 validate -0.17 9.0E-5 NA
90 hsa-miR-222-5p PIK3R3 2.52 0.00142 -0.03 0.95933 mirMAP -0.17 4.0E-5 NA
91 hsa-miR-29b-1-5p PIK3R3 0.34 0.59809 -0.03 0.95933 mirMAP -0.21 3.0E-5 NA
92 hsa-miR-330-3p PIK3R3 2.49 0.00013 -0.03 0.95933 MirTarget -0.19 0.00014 NA
93 hsa-miR-330-5p PIK3R3 2.25 0.00028 -0.03 0.95933 miRanda -0.16 0.00263 NA
94 hsa-miR-365a-3p PIK3R3 0.26 0.65432 -0.03 0.95933 MirTarget -0.33 0 NA
95 hsa-miR-511-5p PIK3R3 1.1 0.17928 -0.03 0.95933 MirTarget -0.18 1.0E-5 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression
96 hsa-miR-590-5p PIK3R3 1.51 0.00239 -0.03 0.95933 miRanda -0.2 0.00312 NA
97 hsa-miR-125a-3p PIK3R5 -0.07 0.92074 0.76 0.28692 miRanda -0.14 0.00747 NA
98 hsa-miR-125a-5p PIK3R5 -1.32 0.00714 0.76 0.28692 MirTarget; miRanda -0.25 0.00223 NA
99 hsa-miR-182-5p PIK3R5 5.87 0 0.76 0.28692 MirTarget -0.25 0 NA
100 hsa-miR-19a-3p PRKAA1 2.17 0.00122 -0.14 0.70846 miRNATAP -0.12 0.00012 NA
101 hsa-miR-19b-3p PRKAA1 1.68 0.00086 -0.14 0.70846 miRNAWalker2 validate; miRTarBase; miRNATAP -0.14 0.00076 NA
102 hsa-miR-590-3p PRKAA1 2.35 0 -0.14 0.70846 MirTarget; miRanda; mirMAP -0.16 0.00015 NA
103 hsa-miR-590-5p PRKAA1 1.51 0.00239 -0.14 0.70846 miRanda -0.13 0.00313 NA
104 hsa-miR-142-5p PRKAA2 3.96 0 -1.64 0.30459 mirMAP -0.73 0 NA
105 hsa-miR-146a-5p PRKAA2 2.65 0.00028 -1.64 0.30459 MirTarget -0.51 3.0E-5 NA
106 hsa-miR-146b-5p PRKAA2 1.88 0.00074 -1.64 0.30459 MirTarget -0.68 3.0E-5 NA
107 hsa-miR-150-3p PRKAA2 1.65 0.05848 -1.64 0.30459 MirTarget; miRNATAP -0.56 0 NA
108 hsa-miR-203a-3p PRKAA2 6.35 0 -1.64 0.30459 MirTarget -0.43 0 NA
109 hsa-miR-22-5p PRKAA2 2.38 1.0E-5 -1.64 0.30459 mirMAP -0.47 0.00457 NA
110 hsa-miR-23a-3p PRKAA2 0.93 0.01273 -1.64 0.30459 mirMAP -0.71 0.00406 NA
111 hsa-miR-27b-5p PRKAA2 0.21 0.71562 -1.64 0.30459 MirTarget; miRNATAP -0.61 8.0E-5 NA
112 hsa-miR-342-3p PRKAA2 1.31 0.02072 -1.64 0.30459 PITA -1.03 0 NA
113 hsa-miR-34c-3p PRKAA2 4.04 0.0002 -1.64 0.30459 PITA -0.35 2.0E-5 NA
114 hsa-miR-34c-5p PRKAA2 2.65 0.01574 -1.64 0.30459 miRNATAP -0.35 2.0E-5 NA
115 hsa-miR-590-3p PRKAA2 2.35 0 -1.64 0.30459 mirMAP; miRNATAP -0.48 0.00777 NA
116 hsa-miR-944 PRKAA2 7.21 0.00082 -1.64 0.30459 mirMAP -0.38 0 NA
117 hsa-miR-15b-3p RICTOR 3.58 0 -0.25 0.52233 mirMAP -0.12 0.00225 NA
118 hsa-miR-16-1-3p RICTOR 2.83 0 -0.25 0.52233 MirTarget -0.14 0.00111 NA
119 hsa-miR-188-5p RICTOR 1.39 0.02516 -0.25 0.52233 MirTarget; PITA; miRNATAP -0.11 0.00114 NA
120 hsa-miR-26b-3p RICTOR 0.99 0.03514 -0.25 0.52233 MirTarget -0.14 0.00252 NA
121 hsa-miR-590-3p RICTOR 2.35 0 -0.25 0.52233 MirTarget; PITA; miRanda; mirMAP; miRNATAP -0.12 0.00543 NA
122 hsa-miR-660-5p RICTOR -0.07 0.88525 -0.25 0.52233 MirTarget -0.2 2.0E-5 NA
123 hsa-miR-1271-5p RPS6KA2 0.21 0.74254 -2.65 0.0006 mirMAP -0.21 0.00269 NA
124 hsa-miR-17-5p RPS6KA2 2.33 2.0E-5 -2.65 0.0006 TargetScan -0.28 0.00049 NA
125 hsa-miR-193a-3p RPS6KA2 0.65 0.20713 -2.65 0.0006 mirMAP -0.24 0.00506 NA
126 hsa-miR-19b-3p RPS6KA2 1.68 0.00086 -2.65 0.0006 MirTarget -0.28 0.00168 NA
127 hsa-miR-200c-3p RPS6KA2 6.47 0 -2.65 0.0006 miRNATAP -0.19 0.00537 NA
128 hsa-miR-30e-5p RPS6KA2 0.78 0.03467 -2.65 0.0006 MirTarget -0.49 5.0E-5 NA
129 hsa-miR-378a-3p RPS6KA2 1.47 0.04667 -2.65 0.0006 MirTarget -0.25 2.0E-5 NA
130 hsa-miR-378c RPS6KA2 0.45 0.49938 -2.65 0.0006 MirTarget -0.19 0.00355 NA
131 hsa-miR-9-3p RPS6KA2 1.69 0.12517 -2.65 0.0006 MirTarget -0.17 2.0E-5 NA
132 hsa-miR-9-5p RPS6KA2 1.8 0.14527 -2.65 0.0006 miRNATAP -0.18 0 NA
133 hsa-miR-141-3p RPS6KA6 7.3 0 -4.02 0.00361 MirTarget -0.31 0.00251 NA
134 hsa-miR-15b-5p RPS6KA6 3.32 0 -4.02 0.00361 MirTarget -0.63 0.00011 NA
135 hsa-miR-16-5p RPS6KA6 2.94 0 -4.02 0.00361 MirTarget -0.76 0 NA
136 hsa-miR-17-5p RPS6KA6 2.33 2.0E-5 -4.02 0.00361 TargetScan -0.43 0.00258 NA
137 hsa-miR-19b-3p RPS6KA6 1.68 0.00086 -4.02 0.00361 MirTarget -0.41 0.00915 NA
138 hsa-miR-20a-3p RPS6KA6 1.99 0.00062 -4.02 0.00361 MirTarget -0.37 0.00636 NA
139 hsa-miR-107 RPS6KB1 1.49 0.00013 0.15 0.60051 PITA; miRanda -0.11 0.00609 NA
140 hsa-miR-186-5p RPS6KB1 0.45 0.18545 0.15 0.60051 MirTarget; miRNATAP -0.19 8.0E-5 NA
141 hsa-miR-125a-5p RPS6KB2 -1.32 0.00714 0.88 0.01183 miRanda -0.17 2.0E-5 NA
142 hsa-miR-330-3p STK11 2.49 0.00013 -0.26 0.64146 mirMAP -0.18 0.0002 NA
143 hsa-miR-330-5p STK11 2.25 0.00028 -0.26 0.64146 miRanda -0.23 1.0E-5 NA
144 hsa-miR-186-5p STRADA 0.45 0.18545 -0.23 0.39724 mirMAP -0.12 0.00877 NA
145 hsa-miR-28-3p TSC1 -0.99 0.01882 -0.16 0.55846 PITA -0.16 1.0E-5 NA
146 hsa-miR-29a-5p TSC1 0.07 0.88413 -0.16 0.55846 mirMAP -0.11 0.00063 NA
147 hsa-miR-320b ULK1 0.2 0.72722 -0.27 0.44303 miRNATAP -0.11 0.00133 NA
148 hsa-miR-338-5p ULK1 -0.11 0.89468 -0.27 0.44303 PITA -0.11 0 NA
149 hsa-miR-92b-3p ULK1 1.69 0.01035 -0.27 0.44303 miRNATAP -0.11 0.00011 NA
150 hsa-let-7f-1-3p ULK2 1.62 0.00069 -0.93 0.02765 MirTarget -0.17 0.00078 NA
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHORYLATION 23 1228 5.64e-21 2.624e-17
2 PROTEIN PHOSPHORYLATION 21 944 2.372e-20 5.518e-17
3 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 24 1977 1.061e-17 1.646e-14
4 INTRACELLULAR SIGNAL TRANSDUCTION 22 1572 3.621e-17 4.212e-14
5 REGULATION OF PHOSPHORUS METABOLIC PROCESS 22 1618 6.681e-17 6.217e-14
6 INOSITOL LIPID MEDIATED SIGNALING 10 124 4.76e-15 3.691e-12
7 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 17 1036 6.51e-14 3.786e-11
8 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 17 1036 6.51e-14 3.786e-11
9 REGULATION OF KINASE ACTIVITY 15 776 3.218e-13 1.664e-10
10 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 19 1656 6.643e-13 3.091e-10
11 PEPTIDYL SERINE MODIFICATION 9 148 1.726e-12 7.299e-10
12 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 6 25 2.16e-12 8.376e-10
13 REGULATION OF TRANSFERASE ACTIVITY 15 946 5.545e-12 1.985e-09
14 POSITIVE REGULATION OF KINASE ACTIVITY 12 482 7.512e-12 2.33e-09
15 NEGATIVE REGULATION OF TOR SIGNALING 6 30 7.201e-12 2.33e-09
16 POSITIVE REGULATION OF RESPONSE TO STIMULUS 19 1929 1.005e-11 2.922e-09
17 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 12 498 1.099e-11 3.008e-09
18 REGULATION OF TOR SIGNALING 7 68 1.523e-11 3.856e-09
19 REGULATION OF PROTEIN MODIFICATION PROCESS 18 1710 1.628e-11 3.856e-09
20 ACTIVATION OF PROTEIN KINASE ACTIVITY 10 279 1.657e-11 3.856e-09
21 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 17 1492 2.32e-11 5.14e-09
22 RESPONSE TO PEPTIDE 11 404 2.592e-11 5.481e-09
23 RESPONSE TO INSULIN 9 205 3.265e-11 6.605e-09
24 CELLULAR RESPONSE TO HORMONE STIMULUS 12 552 3.631e-11 7.039e-09
25 RESPONSE TO HORMONE 14 893 4.196e-11 7.809e-09
26 CELL ACTIVATION 12 568 5.052e-11 9.042e-09
27 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 15 1135 7.345e-11 1.266e-08
28 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 12 616 1.287e-10 2.139e-08
29 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 6 49 1.659e-10 2.662e-08
30 RESPONSE TO ABIOTIC STIMULUS 14 1024 2.56e-10 3.97e-08
31 RESPONSE TO NITROGEN COMPOUND 13 859 3.992e-10 5.991e-08
32 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 12 689 4.641e-10 6.748e-08
33 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 9 289 6.904e-10 9.734e-08
34 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 7 120 8.806e-10 1.205e-07
35 RESPONSE TO OXYGEN CONTAINING COMPOUND 15 1381 1.137e-09 1.512e-07
36 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 74 2.135e-09 2.759e-07
37 RESPONSE TO ENDOGENOUS STIMULUS 15 1450 2.229e-09 2.803e-07
38 POSITIVE REGULATION OF AUTOPHAGY 6 75 2.318e-09 2.838e-07
39 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 12 799 2.492e-09 2.973e-07
40 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 10 470 2.663e-09 3.098e-07
41 PLATELET ACTIVATION 7 142 2.869e-09 3.105e-07
42 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 13 1008 2.803e-09 3.105e-07
43 REGULATION OF CELL ADHESION 11 629 2.814e-09 3.105e-07
44 REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 5 36 3.238e-09 3.424e-07
45 CELLULAR RESPONSE TO INSULIN STIMULUS 7 146 3.484e-09 3.524e-07
46 T CELL RECEPTOR SIGNALING PATHWAY 7 146 3.484e-09 3.524e-07
47 POSITIVE REGULATION OF CATALYTIC ACTIVITY 15 1518 4.182e-09 4.14e-07
48 POSITIVE REGULATION OF MOLECULAR FUNCTION 16 1791 4.271e-09 4.14e-07
49 CELL CYCLE ARREST 7 154 5.054e-09 4.799e-07
50 CELLULAR RESPONSE TO NITROGEN COMPOUND 10 505 5.297e-09 4.929e-07
51 REGULATION OF AUTOPHAGY 8 249 5.474e-09 4.994e-07
52 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 12 867 6.244e-09 5.587e-07
53 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 6 89 6.581e-09 5.778e-07
54 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 16 1848 6.723e-09 5.793e-07
55 POSITIVE REGULATION OF CELL ADHESION 9 376 6.904e-09 5.841e-07
56 REGULATION OF CELLULAR CARBOHYDRATE CATABOLIC PROCESS 5 42 7.254e-09 5.922e-07
57 REGULATION OF CARBOHYDRATE CATABOLIC PROCESS 5 42 7.254e-09 5.922e-07
58 CELLULAR RESPONSE TO PEPTIDE 8 274 1.156e-08 9.277e-07
59 LIPID PHOSPHORYLATION 6 99 1.254e-08 9.893e-07
60 REGULATION OF CATABOLIC PROCESS 11 731 1.339e-08 1.038e-06
61 POSITIVE REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 4 17 1.439e-08 1.098e-06
62 RESPONSE TO WOUNDING 10 563 1.491e-08 1.119e-06
63 REGULATION OF NUCLEOSIDE METABOLIC PROCESS 5 49 1.613e-08 1.173e-06
64 REGULATION OF ATP METABOLIC PROCESS 5 49 1.613e-08 1.173e-06
65 REGULATION OF CELL CYCLE 12 949 1.712e-08 1.225e-06
66 REGULATION OF COENZYME METABOLIC PROCESS 5 50 1.79e-08 1.243e-06
67 REGULATION OF COFACTOR METABOLIC PROCESS 5 50 1.79e-08 1.243e-06
68 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 7 193 2.414e-08 1.652e-06
69 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 7 195 2.592e-08 1.748e-06
70 REGULATION OF CELL DEATH 14 1472 2.781e-08 1.849e-06
71 CARDIOVASCULAR SYSTEM DEVELOPMENT 11 788 2.898e-08 1.873e-06
72 CIRCULATORY SYSTEM DEVELOPMENT 11 788 2.898e-08 1.873e-06
73 RESPONSE TO OXYGEN LEVELS 8 311 3.094e-08 1.972e-06
74 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 6 118 3.609e-08 2.269e-06
75 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 5 59 4.185e-08 2.597e-06
76 LIPID MODIFICATION 7 210 4.314e-08 2.641e-06
77 REGULATION OF GLUCOSE IMPORT 5 60 4.561e-08 2.676e-06
78 POSITIVE REGULATION OF CELL COMMUNICATION 14 1532 4.608e-08 2.676e-06
79 GLYCEROLIPID BIOSYNTHETIC PROCESS 7 211 4.457e-08 2.676e-06
80 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 13 1275 4.658e-08 2.676e-06
81 VASCULATURE DEVELOPMENT 9 469 4.646e-08 2.676e-06
82 WOUND HEALING 9 470 4.731e-08 2.685e-06
83 RESPONSE TO EXTERNAL STIMULUS 15 1821 4.923e-08 2.76e-06
84 CELL MOTILITY 11 835 5.24e-08 2.869e-06
85 LOCALIZATION OF CELL 11 835 5.24e-08 2.869e-06
86 POSITIVE REGULATION OF NUCLEOSIDE METABOLIC PROCESS 4 24 6.374e-08 3.409e-06
87 POSITIVE REGULATION OF ATP METABOLIC PROCESS 4 24 6.374e-08 3.409e-06
88 NEGATIVE REGULATION OF CELL DEATH 11 872 8.146e-08 4.307e-06
89 REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 8 354 8.4e-08 4.392e-06
90 REGULATION OF BODY FLUID LEVELS 9 506 8.885e-08 4.594e-06
91 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 6 138 9.193e-08 4.701e-06
92 PHOSPHOLIPID BIOSYNTHETIC PROCESS 7 235 9.314e-08 4.71e-06
93 LOCOMOTION 12 1114 1.002e-07 5.014e-06
94 LIPID BIOSYNTHETIC PROCESS 9 539 1.52e-07 7.523e-06
95 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 6 154 1.763e-07 8.636e-06
96 PROTEIN KINASE B SIGNALING 4 34 2.75e-07 1.333e-05
97 REGULATION OF CELLULAR COMPONENT MOVEMENT 10 771 2.828e-07 1.356e-05
98 REGULATION OF CELL PROLIFERATION 13 1496 3.021e-07 1.434e-05
99 POSITIVE REGULATION OF LOCOMOTION 8 420 3.101e-07 1.456e-05
100 GLUCOSE HOMEOSTASIS 6 170 3.161e-07 1.456e-05
101 CARBOHYDRATE HOMEOSTASIS 6 170 3.161e-07 1.456e-05
102 REGULATION OF LIPID METABOLIC PROCESS 7 282 3.21e-07 1.465e-05
103 REGULATION OF EPITHELIAL CELL PROLIFERATION 7 285 3.448e-07 1.556e-05
104 REGULATION OF CELL SUBSTRATE ADHESION 6 173 3.504e-07 1.556e-05
105 REGULATION OF CELL MATRIX ADHESION 5 90 3.544e-07 1.556e-05
106 REGULATION OF TRANSPORT 14 1804 3.535e-07 1.556e-05
107 NEGATIVE REGULATION OF CELL CYCLE 8 433 3.908e-07 1.699e-05
108 ANGIOGENESIS 7 293 4.156e-07 1.79e-05
109 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 7 296 4.451e-07 1.9e-05
110 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 7 297 4.553e-07 1.926e-05
111 CELLULAR RESPONSE TO STRESS 13 1565 5.081e-07 2.13e-05
112 REGULATION OF GLUCOSE TRANSPORT 5 100 6e-07 2.493e-05
113 HEMOSTASIS 7 311 6.205e-07 2.555e-05
114 POSITIVE REGULATION OF MAPK CASCADE 8 470 7.26e-07 2.963e-05
115 REGULATION OF MAP KINASE ACTIVITY 7 319 7.358e-07 2.977e-05
116 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 7 323 7.998e-07 3.208e-05
117 REGULATION OF MAPK CASCADE 9 660 8.332e-07 3.314e-05
118 IMMUNE EFFECTOR PROCESS 8 486 9.338e-07 3.682e-05
119 POSITIVE REGULATION OF MAP KINASE ACTIVITY 6 207 1.003e-06 3.922e-05
120 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 13 1672 1.083e-06 4.198e-05
121 IMMUNE SYSTEM PROCESS 14 1984 1.131e-06 4.312e-05
122 REGULATION OF NUCLEOTIDE METABOLIC PROCESS 6 211 1.121e-06 4.312e-05
123 REGULATION OF IMMUNE SYSTEM PROCESS 12 1403 1.203e-06 4.55e-05
124 GLYCEROLIPID METABOLIC PROCESS 7 356 1.531e-06 5.744e-05
125 PHOSPHOLIPID METABOLIC PROCESS 7 364 1.774e-06 6.553e-05
126 BLOOD VESSEL MORPHOGENESIS 7 364 1.774e-06 6.553e-05
127 NEGATIVE REGULATION OF CELL COMMUNICATION 11 1192 1.844e-06 6.755e-05
128 TOR SIGNALING 3 16 2.259e-06 8.21e-05
129 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 3 17 2.739e-06 9.881e-05
130 AUTOPHAGY 7 394 2.998e-06 0.0001073
131 POSITIVE REGULATION OF CATABOLIC PROCESS 7 395 3.048e-06 0.0001083
132 REGULATION OF NEURON DEATH 6 252 3.139e-06 0.0001107
133 FC EPSILON RECEPTOR SIGNALING PATHWAY 5 142 3.4e-06 0.0001189
134 CELLULAR RESPONSE TO OXYGEN LEVELS 5 143 3.519e-06 0.0001222
135 IMMUNE SYSTEM DEVELOPMENT 8 582 3.578e-06 0.0001233
136 LEUKOCYTE MIGRATION 6 259 3.676e-06 0.0001258
137 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 4 68 4.642e-06 0.0001577
138 POSITIVE REGULATION OF CELL PROLIFERATION 9 814 4.687e-06 0.000158
139 CELL CYCLE 11 1316 4.823e-06 0.0001615
140 RESPONSE TO ACTIVITY 4 69 4.922e-06 0.0001636
141 ACTIVATION OF IMMUNE RESPONSE 7 427 5.089e-06 0.0001679
142 POSITIVE REGULATION OF NEUROBLAST PROLIFERATION 3 21 5.334e-06 0.0001748
143 RESPONSE TO PURINE CONTAINING COMPOUND 5 158 5.732e-06 0.0001865
144 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 7 437 5.922e-06 0.0001914
145 CELL CYCLE PROCESS 10 1081 6.036e-06 0.0001937
146 PEPTIDYL AMINO ACID MODIFICATION 9 841 6.11e-06 0.0001947
147 RESPONSE TO EXTRACELLULAR STIMULUS 7 441 6.286e-06 0.000199
148 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 5 162 6.476e-06 0.0002036
149 POSITIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS 4 75 6.872e-06 0.0002146
150 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 7 448 6.967e-06 0.0002161
151 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 7 450 7.173e-06 0.000221
152 LEUKOCYTE DIFFERENTIATION 6 292 7.313e-06 0.0002239
153 LYMPHOCYTE COSTIMULATION 4 78 8.037e-06 0.0002444
154 CHEMICAL HOMEOSTASIS 9 874 8.341e-06 0.000252
155 ERBB SIGNALING PATHWAY 4 79 8.456e-06 0.0002534
156 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 9 876 8.496e-06 0.0002534
157 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 5 172 8.667e-06 0.0002569
158 INSULIN RECEPTOR SIGNALING PATHWAY 4 80 8.891e-06 0.0002618
159 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 10 1152 1.058e-05 0.0003096
160 POSITIVE REGULATION OF GENE EXPRESSION 12 1733 1.088e-05 0.0003165
161 REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 27 1.165e-05 0.0003367
162 CELLULAR LIPID METABOLIC PROCESS 9 913 1.185e-05 0.0003404
163 REGULATION OF CELLULAR RESPONSE TO STRESS 8 691 1.258e-05 0.0003591
164 REGULATION OF NEUROBLAST PROLIFERATION 3 28 1.304e-05 0.0003698
165 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 9 926 1.327e-05 0.0003743
166 REGULATION OF RESPONSE TO STRESS 11 1468 1.371e-05 0.0003843
167 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 9 957 1.727e-05 0.0004811
168 FC GAMMA RECEPTOR SIGNALING PATHWAY 4 95 1.759e-05 0.0004871
169 NEGATIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 3 31 1.783e-05 0.0004908
170 LYMPHOCYTE ACTIVATION 6 342 1.795e-05 0.0004912
171 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 4 98 1.989e-05 0.0005411
172 FC RECEPTOR SIGNALING PATHWAY 5 206 2.073e-05 0.0005574
173 POSITIVE REGULATION OF CELL SUBSTRATE ADHESION 4 99 2.07e-05 0.0005574
174 LYMPHOCYTE DIFFERENTIATION 5 209 2.222e-05 0.0005941
175 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 5 213 2.433e-05 0.000647
176 CELL DEATH 9 1001 2.468e-05 0.0006524
177 REGULATION OF CELLULAR COMPONENT BIOGENESIS 8 767 2.67e-05 0.0007019
178 TUBE DEVELOPMENT 7 552 2.688e-05 0.0007028
179 REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 3 37 3.061e-05 0.0007912
180 POSITIVE REGULATION OF IMMUNE RESPONSE 7 563 3.05e-05 0.0007912
181 REGULATED EXOCYTOSIS 5 224 3.097e-05 0.0007962
182 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 5 229 3.442e-05 0.0008752
183 SINGLE ORGANISM BEHAVIOR 6 384 3.441e-05 0.0008752
184 PROTEIN HETEROOLIGOMERIZATION 4 113 3.484e-05 0.0008809
185 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 8 801 3.64e-05 0.0009154
186 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 3 40 3.879e-05 0.0009651
187 POSITIVE REGULATION OF CELL MATRIX ADHESION 3 40 3.879e-05 0.0009651
188 POSITIVE REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 3 42 4.497e-05 0.001101
189 POSITIVE REGULATION OF GLUCOSE TRANSPORT 3 42 4.497e-05 0.001101
190 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 10 1360 4.457e-05 0.001101
191 POSITIVE REGULATION OF CELL CELL ADHESION 5 243 4.567e-05 0.001107
192 REGULATION OF PROTEIN KINASE B SIGNALING 4 121 4.554e-05 0.001107
193 RESPONSE TO ELECTRICAL STIMULUS 3 43 4.828e-05 0.001159
194 POSITIVE REGULATION OF MITOTIC CELL CYCLE 4 123 4.855e-05 0.001159
195 T CELL DIFFERENTIATION 4 123 4.855e-05 0.001159
196 REGULATION OF CELL DEVELOPMENT 8 836 4.931e-05 0.001171
197 LEUKOCYTE ACTIVATION 6 414 5.233e-05 0.001236
198 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 10 1395 5.534e-05 0.001301
199 LEUKOCYTE CELL CELL ADHESION 5 255 5.742e-05 0.001343
200 NEUROGENESIS 10 1402 5.775e-05 0.001343
201 NEGATIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 4 131 6.208e-05 0.001437
202 REGULATION OF GROWTH 7 633 6.416e-05 0.001471
203 POSITIVE REGULATION OF CELL DIVISION 4 132 6.395e-05 0.001471
204 POSITIVE REGULATION OF PURINE NUCLEOTIDE METABOLIC PROCESS 4 133 6.585e-05 0.001477
205 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 4 133 6.585e-05 0.001477
206 REGULATION OF LIPID KINASE ACTIVITY 3 48 6.729e-05 0.001477
207 POSITIVE REGULATION OF NUCLEOTIDE METABOLIC PROCESS 4 133 6.585e-05 0.001477
208 POSITIVE REGULATION OF RESPONSE TO EXTRACELLULAR STIMULUS 3 48 6.729e-05 0.001477
209 RESPONSE TO DRUG 6 431 6.54e-05 0.001477
210 CELL DEVELOPMENT 10 1426 6.668e-05 0.001477
211 POSITIVE REGULATION OF RESPONSE TO NUTRIENT LEVELS 3 48 6.729e-05 0.001477
212 CELLULAR RESPONSE TO ABIOTIC STIMULUS 5 263 6.647e-05 0.001477
213 CELLULAR RESPONSE TO EXTERNAL STIMULUS 5 264 6.767e-05 0.001478
214 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 9 1142 6.93e-05 0.001507
215 LIPID METABOLIC PROCESS 9 1158 7.718e-05 0.00167
216 REGULATION OF CELL DIVISION 5 272 7.792e-05 0.001679
217 REGULATION OF ORGANELLE ORGANIZATION 9 1178 8.808e-05 0.001889
218 RESPONSE TO LIGHT STIMULUS 5 280 8.933e-05 0.001907
219 NEURON PROJECTION EXTENSION 3 53 9.063e-05 0.001926
220 SINGLE ORGANISM CELL ADHESION 6 459 9.254e-05 0.001957
221 NEGATIVE REGULATION OF REPRODUCTIVE PROCESS 3 54 9.585e-05 0.00201
222 REGULATION OF VESICLE MEDIATED TRANSPORT 6 462 9.591e-05 0.00201
223 REGULATION OF CELL DIFFERENTIATION 10 1492 9.76e-05 0.002037
224 TAXIS 6 464 9.822e-05 0.00204
225 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 55 0.0001013 0.002094
226 REGULATION OF DEVELOPMENTAL GROWTH 5 289 0.0001037 0.002134
227 RESPONSE TO STARVATION 4 154 0.0001163 0.002383
228 VESICLE MEDIATED TRANSPORT 9 1239 0.0001297 0.002648
229 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 0.0001314 0.002669
230 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 3 61 0.000138 0.002768
231 REGULATION OF HOMOTYPIC CELL CELL ADHESION 5 307 0.0001376 0.002768
232 POSITIVE REGULATION OF STEM CELL PROLIFERATION 3 61 0.000138 0.002768
233 EXOCYTOSIS 5 310 0.000144 0.002875
234 POSITIVE REGULATION OF CELL ACTIVATION 5 311 0.0001462 0.002906
235 RESPONSE TO OSMOTIC STRESS 3 63 0.0001519 0.003008
236 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 8 983 0.0001531 0.003019
237 REGULATION OF EPITHELIAL CELL MIGRATION 4 166 0.0001552 0.003047
238 RESPONSE TO CARBOHYDRATE 4 168 0.0001625 0.003164
239 REGULATION OF AXONOGENESIS 4 168 0.0001625 0.003164
240 REGULATION OF CELLULAR LOCALIZATION 9 1277 0.0001633 0.003166
241 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 513 0.0001699 0.003281
242 REGULATION OF RESPONSE TO EXTRACELLULAR STIMULUS 4 171 0.000174 0.00329
243 FATTY ACID HOMEOSTASIS 2 12 0.0001725 0.00329
244 REGULATION OF RESPONSE TO NUTRIENT LEVELS 4 171 0.000174 0.00329
245 NEGATIVE REGULATION OF NEURON DEATH 4 171 0.000174 0.00329
246 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 2 12 0.0001725 0.00329
247 BEHAVIOR 6 516 0.0001754 0.003304
248 REGULATION OF CELL SIZE 4 172 0.0001779 0.003338
249 CELLULAR RESPONSE TO DRUG 3 67 0.0001824 0.003409
250 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 7 750 0.0001846 0.003436
251 POSITIVE REGULATION OF AXONOGENESIS 3 69 0.0001991 0.003691
252 INDUCTION OF POSITIVE CHEMOTAXIS 2 13 0.0002036 0.003759
253 REGULATION OF CELLULAR COMPONENT SIZE 5 337 0.0002123 0.003905
254 HOMEOSTATIC PROCESS 9 1337 0.000231 0.004231
255 SINGLE ORGANISM BIOSYNTHETIC PROCESS 9 1340 0.0002349 0.004247
256 CELLULAR RESPONSE TO ELECTRICAL STIMULUS 2 14 0.0002373 0.004247
257 REGULATION OF FIBROBLAST APOPTOTIC PROCESS 2 14 0.0002373 0.004247
258 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 14 0.0002373 0.004247
259 T CELL MIGRATION 2 14 0.0002373 0.004247
260 REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 3 73 0.0002353 0.004247
261 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 3 74 0.0002449 0.004367
262 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 4 188 0.00025 0.00444
263 GRANULOCYTE MIGRATION 3 75 0.0002549 0.004492
264 CELLULAR GLUCOSE HOMEOSTASIS 3 75 0.0002549 0.004492
265 PHAGOCYTOSIS 4 190 0.0002603 0.00457
266 NUCLEAR TRANSPORT 5 355 0.0002701 0.004721
267 PROTEIN AUTOPHOSPHORYLATION 4 192 0.0002709 0.004721
268 RESPIRATORY BURST 2 15 0.0002735 0.004744
269 REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 3 77 0.0002755 0.004744
270 DEVELOPMENTAL CELL GROWTH 3 77 0.0002755 0.004744
271 DEVELOPMENTAL MATURATION 4 193 0.0002763 0.004744
272 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 5 360 0.0002881 0.004929
273 RESPONSE TO ALCOHOL 5 362 0.0002956 0.005037
274 RESPIRATORY SYSTEM DEVELOPMENT 4 197 0.0002987 0.005073
275 NEGATIVE REGULATION OF LIPID METABOLIC PROCESS 3 80 0.0003084 0.005202
276 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 6 573 0.0003086 0.005202
277 CIRCULATORY SYSTEM PROCESS 5 366 0.0003109 0.005222
278 POSITIVE REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 16 0.0003123 0.005227
279 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 3 81 0.0003199 0.005315
280 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 5 368 0.0003188 0.005315
281 REGULATION OF TRANSLATIONAL INITIATION 3 82 0.0003316 0.005492
282 NEGATIVE REGULATION OF CATABOLIC PROCESS 4 203 0.0003348 0.005524
283 REGULATION OF ENERGY HOMEOSTASIS 2 17 0.0003535 0.005764
284 SECRETION 6 588 0.0003543 0.005764
285 MAMMARY GLAND ALVEOLUS DEVELOPMENT 2 17 0.0003535 0.005764
286 MAMMARY GLAND LOBULE DEVELOPMENT 2 17 0.0003535 0.005764
287 REGULATION OF CELL CELL ADHESION 5 380 0.0003693 0.005988
288 CELLULAR RESPONSE TO PROSTAGLANDIN E STIMULUS 2 18 0.0003973 0.006375
289 RESPONSE TO CAFFEINE 2 18 0.0003973 0.006375
290 MAST CELL MEDIATED IMMUNITY 2 18 0.0003973 0.006375
291 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 6 602 0.0004016 0.006422
292 REGULATION OF STEM CELL PROLIFERATION 3 88 0.0004082 0.006482
293 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 3 88 0.0004082 0.006482
294 REGULATION OF IMMUNE RESPONSE 7 858 0.0004191 0.006633
295 CELL CELL ADHESION 6 608 0.0004234 0.006678
296 GLAND DEVELOPMENT 5 395 0.0004409 0.00693
297 CELLULAR RESPONSE TO LIGHT STIMULUS 3 91 0.0004504 0.007056
298 REGULATION OF PROTEIN STABILITY 4 221 0.0004617 0.007209
299 MORPHOGENESIS OF AN EPITHELIUM 5 400 0.0004669 0.007265
300 NEURON DIFFERENTIATION 7 874 0.0004684 0.007265
301 NEURON PROJECTION MORPHOGENESIS 5 402 0.0004776 0.007383
302 EMBRYONIC HEMOPOIESIS 2 20 0.0004924 0.007536
303 CELLULAR RESPONSE TO GROWTH HORMONE STIMULUS 2 20 0.0004924 0.007536
304 RESPONSE TO MUSCLE ACTIVITY 2 20 0.0004924 0.007536
305 ORGANOPHOSPHATE METABOLIC PROCESS 7 885 0.0005049 0.007703
306 GROWTH 5 410 0.0005224 0.007944
307 CARDIOCYTE DIFFERENTIATION 3 96 0.0005267 0.007983
308 EMBRYO DEVELOPMENT 7 894 0.0005365 0.008082
309 MAST CELL ACTIVATION 2 21 0.0005437 0.008082
310 POSITIVE T CELL SELECTION 2 21 0.0005437 0.008082
311 RESPONSE TO RADIATION 5 413 0.00054 0.008082
312 POSITIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 2 21 0.0005437 0.008082
313 NEGATIVE REGULATION OF LIPID CATABOLIC PROCESS 2 21 0.0005437 0.008082
314 REGULATION OF VASCULATURE DEVELOPMENT 4 233 0.0005634 0.008348
315 MYELOID LEUKOCYTE MIGRATION 3 99 0.0005763 0.008512
316 POSITIVE REGULATION OF TRANSLATIONAL INITIATION 2 22 0.0005974 0.008659
317 POSITIVE REGULATION OF PROTEIN AUTOPHOSPHORYLATION 2 22 0.0005974 0.008659
318 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 100 0.0005934 0.008659
319 REGULATION OF CELLULAR RESPIRATION 2 22 0.0005974 0.008659
320 TISSUE DEVELOPMENT 9 1518 0.0005918 0.008659
321 ERK1 AND ERK2 CASCADE 2 22 0.0005974 0.008659
322 RESPONSE TO ORGANIC CYCLIC COMPOUND 7 917 0.0006243 0.009022
323 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 3 103 0.0006468 0.009318
324 LYSOSOME LOCALIZATION 2 23 0.0006536 0.009329
325 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO STRESS 2 23 0.0006536 0.009329
326 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 2 23 0.0006536 0.009329
327 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 3 104 0.0006653 0.009467
328 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 5 437 0.0006973 0.009892
329 POSITIVE REGULATION OF TRANSPORT 7 936 0.0007053 0.009975
330 CELLULAR RESPONSE TO PROSTAGLANDIN STIMULUS 2 24 0.0007123 0.009983
331 REGULATION OF POSITIVE CHEMOTAXIS 2 24 0.0007123 0.009983
332 POSITIVE REGULATION OF CELL JUNCTION ASSEMBLY 2 24 0.0007123 0.009983
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 22 842 5.182e-23 4.814e-20
2 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 22 992 1.834e-21 8.519e-19
3 PROTEIN SERINE THREONINE KINASE ACTIVITY 16 445 2.279e-18 7.057e-16
4 PROTEIN KINASE ACTIVITY 17 640 2.274e-17 5.282e-15
5 ADENYL NUCLEOTIDE BINDING 18 1514 2.09e-12 3.884e-10
6 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 70 1.879e-11 2.909e-09
7 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 6 43 7.283e-11 8.457e-09
8 RIBONUCLEOTIDE BINDING 18 1860 6.633e-11 8.457e-09
9 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 6 51 2.132e-10 2.2e-08
10 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 4 16 1.102e-08 1.024e-06
11 KINASE REGULATOR ACTIVITY 7 186 1.871e-08 1.58e-06
12 KINASE BINDING 9 606 4.082e-07 3.16e-05
13 INSULIN RECEPTOR SUBSTRATE BINDING 3 11 6.692e-07 4.782e-05
14 ENZYME BINDING 13 1737 1.669e-06 0.0001107
15 ENZYME REGULATOR ACTIVITY 10 959 2.07e-06 0.0001282
16 KINASE ACTIVATOR ACTIVITY 4 62 3.202e-06 0.0001859
17 MOLECULAR FUNCTION REGULATOR 11 1353 6.298e-06 0.0003442
18 INSULIN RECEPTOR BINDING 3 32 1.965e-05 0.001014
19 PROTEIN SERINE THREONINE TYROSINE KINASE ACTIVITY 3 39 3.592e-05 0.001756
20 ENZYME ACTIVATOR ACTIVITY 6 471 0.0001066 0.004953
21 GROWTH FACTOR ACTIVITY 4 160 0.0001347 0.00596
22 PHOSPHATASE BINDING 4 162 0.0001413 0.005967
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 1.286e-15 7.511e-13
2 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 11 237 7.889e-14 2.304e-11
3 EXTRINSIC COMPONENT OF MEMBRANE 8 252 6.012e-09 1.17e-06
4 TRANSFERASE COMPLEX 11 703 8.943e-09 1.306e-06
5 CATALYTIC COMPLEX 11 1038 4.703e-07 5.493e-05
6 PROTEIN KINASE COMPLEX 4 90 1.42e-05 0.001382
7 PLATELET ALPHA GRANULE LUMEN 3 55 0.0001013 0.008449

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04150_mTOR_signaling_pathway 33 52 7.926e-92 1.427e-89
2 hsa04151_PI3K_AKT_signaling_pathway 23 351 1.59e-33 1.431e-31
3 hsa04910_Insulin_signaling_pathway 18 138 3.785e-31 2.271e-29
4 hsa04012_ErbB_signaling_pathway 13 87 4.178e-23 1.504e-21
5 hsa04914_Progesterone.mediated_oocyte_maturation 13 87 4.178e-23 1.504e-21
6 hsa04510_Focal_adhesion 15 200 5.203e-22 1.561e-20
7 hsa04960_Aldosterone.regulated_sodium_reabsorption 10 42 4.678e-20 1.203e-18
8 hsa04722_Neurotrophin_signaling_pathway 12 127 8.004e-19 1.801e-17
9 hsa04666_Fc_gamma_R.mediated_phagocytosis 11 95 2.713e-18 5.426e-17
10 hsa04370_VEGF_signaling_pathway 10 76 2.928e-17 5.271e-16
11 hsa04662_B_cell_receptor_signaling_pathway 9 75 3.202e-15 5.24e-14
12 hsa04973_Carbohydrate_digestion_and_absorption 8 44 3.729e-15 5.593e-14
13 hsa04664_Fc_epsilon_RI_signaling_pathway 9 79 5.225e-15 7.234e-14
14 hsa04620_Toll.like_receptor_signaling_pathway 9 102 5.671e-14 7.292e-13
15 hsa04014_Ras_signaling_pathway 11 236 7.531e-14 9.037e-13
16 hsa04660_T_cell_receptor_signaling_pathway 9 108 9.622e-14 1.082e-12
17 hsa04062_Chemokine_signaling_pathway 10 189 3.427e-13 3.629e-12
18 hsa04380_Osteoclast_differentiation 9 128 4.589e-13 4.589e-12
19 hsa04650_Natural_killer_cell_mediated_cytotoxicity 9 136 7.987e-13 7.567e-12
20 hsa04210_Apoptosis 8 89 1.413e-12 1.272e-11
21 hsa04070_Phosphatidylinositol_signaling_system 7 78 4.103e-11 3.517e-10
22 hsa04810_Regulation_of_actin_cytoskeleton 9 214 4.795e-11 3.923e-10
23 hsa04630_Jak.STAT_signaling_pathway 8 155 1.278e-10 1e-09
24 hsa04670_Leukocyte_transendothelial_migration 7 117 7.367e-10 5.525e-09
25 hsa04140_Regulation_of_autophagy 4 34 2.75e-07 1.98e-06
26 hsa00562_Inositol_phosphate_metabolism 4 57 2.281e-06 1.579e-05
27 hsa04920_Adipocytokine_signaling_pathway 4 68 4.642e-06 3.095e-05
28 hsa04720_Long.term_potentiation 4 70 5.214e-06 3.352e-05
29 hsa04114_Oocyte_meiosis 4 114 3.606e-05 0.0002238
30 hsa04010_MAPK_signaling_pathway 5 268 7.266e-05 0.000436
31 hsa04730_Long.term_depression 3 70 0.0002078 0.001206
32 hsa04350_TGF.beta_signaling_pathway 3 85 0.0003686 0.002074
33 hsa04270_Vascular_smooth_muscle_contraction 2 116 0.01566 0.08543
34 hsa03013_RNA_transport 2 152 0.02597 0.1375

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 HAND2-AS1 hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-32-3p;hsa-miR-33a-3p;hsa-miR-486-5p;hsa-miR-629-5p;hsa-miR-940 15 IGF1 Sponge network -7.871 0 -4.485 0.00149 0.653
2 EMX2OS hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-32-3p;hsa-miR-452-5p;hsa-miR-486-5p;hsa-miR-629-5p;hsa-miR-940 14 IGF1 Sponge network -6.205 0.00015 -4.485 0.00149 0.631
3 RP11-389C8.2 hsa-let-7f-1-3p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-301a-3p;hsa-miR-33a-3p 10 IGF1 Sponge network -3.089 2.0E-5 -4.485 0.00149 0.575
4 MAGI2-AS3 hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-301a-3p;hsa-miR-32-3p;hsa-miR-33a-3p;hsa-miR-576-5p;hsa-miR-629-5p;hsa-miR-940 16 IGF1 Sponge network -4.563 0 -4.485 0.00149 0.572
5 RP11-887P2.5 hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-27a-3p;hsa-miR-486-5p;hsa-miR-576-5p;hsa-miR-940 11 IGF1 Sponge network -9.865 1.0E-5 -4.485 0.00149 0.567
6 AC003090.1 hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-576-5p 11 IGF1 Sponge network -7.817 0.00161 -4.485 0.00149 0.561
7 MIR497HG hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-301a-3p;hsa-miR-33a-3p;hsa-miR-940 13 IGF1 Sponge network -6.146 0.00024 -4.485 0.00149 0.518
8 ADAMTS9-AS1 hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-301a-3p;hsa-miR-576-5p;hsa-miR-629-5p;hsa-miR-940 14 IGF1 Sponge network -8.573 0.00012 -4.485 0.00149 0.499
9 WT1-AS hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-301a-3p;hsa-miR-32-3p;hsa-miR-33a-3p;hsa-miR-576-5p;hsa-miR-629-5p;hsa-miR-940 16 IGF1 Sponge network -6.875 2.0E-5 -4.485 0.00149 0.493
10 MIR143HG hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-301a-3p;hsa-miR-33a-3p;hsa-miR-576-5p;hsa-miR-629-5p;hsa-miR-940 14 IGF1 Sponge network -6.51 0 -4.485 0.00149 0.49
11 DNM3OS hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-301a-3p;hsa-miR-33a-3p;hsa-miR-576-5p;hsa-miR-940 14 IGF1 Sponge network -3.933 0.00059 -4.485 0.00149 0.483
12 RP11-166D19.1 hsa-let-7f-1-3p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-33a-3p;hsa-miR-452-5p;hsa-miR-576-5p 12 IGF1 Sponge network -4.209 2.0E-5 -4.485 0.00149 0.477
13 ZNF667-AS1 hsa-let-7f-1-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-452-5p;hsa-miR-629-5p 10 IGF1 Sponge network -4.019 0.00137 -4.485 0.00149 0.383
14 FAM66C hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-940 10 IGF1 Sponge network -2.927 0.00012 -4.485 0.00149 0.38
15 ACTA2-AS1 hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-33a-3p;hsa-miR-576-5p 12 IGF1 Sponge network -6.142 0.00223 -4.485 0.00149 0.332

Quest ID: 19225f54d0679c3923c2c9052d709fd3