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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-107 SDPR 1.31 0 -4.38 0 miRanda -0.89 0 NA
2 hsa-miR-126-5p SDPR 0.9 2.0E-5 -4.38 0 MirTarget; mirMAP -0.21 0.04126 NA
3 hsa-miR-142-3p SDPR 2.75 0 -4.38 0 miRanda -0.24 1.0E-5 NA
4 hsa-miR-144-3p SDPR 0.66 0.14694 -4.38 0 MirTarget -0.19 0.00013 NA
5 hsa-miR-186-5p SDPR 1.47 0 -4.38 0 MirTarget -0.93 0 NA
6 hsa-miR-29b-2-5p SDPR 0.91 0.00667 -4.38 0 MirTarget -0.25 9.0E-5 NA
7 hsa-miR-32-5p SDPR 2.34 0 -4.38 0 miRNATAP -0.73 0 NA
8 hsa-miR-335-3p SDPR 3.09 0 -4.38 0 MirTarget -0.25 0 NA
9 hsa-miR-339-5p SDPR 2.69 0 -4.38 0 miRanda -0.56 0 NA
10 hsa-miR-33a-3p SDPR 1.73 0 -4.38 0 MirTarget -0.49 0 NA
11 hsa-miR-3653-3p SDPR 1.86 0 -4.38 0 MirTarget -0.47 0 NA
12 hsa-miR-421 SDPR 1.18 1.0E-5 -4.38 0 miRanda -0.46 0 NA
13 hsa-miR-511-5p SDPR 1.04 0.00234 -4.38 0 MirTarget -0.15 0.01505 NA
14 hsa-miR-590-3p SDPR 2.59 0 -4.38 0 miRanda -0.79 0 NA
15 hsa-miR-590-5p SDPR 3.18 0 -4.38 0 miRanda -0.78 0 NA
16 hsa-miR-92a-3p SDPR 2.06 0 -4.38 0 miRNATAP -0.98 0 NA
17 hsa-miR-92b-3p SDPR 1.2 0 -4.38 0 miRNATAP -0.34 4.0E-5 NA
18 hsa-miR-944 SDPR 2.91 0 -4.38 0 mirMAP -0.29 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 COFACTOR METABOLIC PROCESS 7 334 3.95e-06 0.008942
2 MONOSACCHARIDE CATABOLIC PROCESS 4 59 5.766e-06 0.008942
3 HEXOSE CATABOLIC PROCESS 4 49 2.723e-06 0.008942
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 HIF_1_signaling_pathway_hsa04066 3 100 0.001048 0.05448
2 Peroxisome_hsa04146 2 83 0.01198 0.3116

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 MIR143HG hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-944 15 SDPR Sponge network -4.237 0 -4.377 0 0.708
2 ADAMTS9-AS1 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-511-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-944 17 SDPR Sponge network -7.614 0 -4.377 0 0.699
3 MAGI2-AS3 hsa-miR-107;hsa-miR-126-5p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-590-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-944 14 SDPR Sponge network -2.414 0 -4.377 0 0.653
4 RP11-166D19.1 hsa-miR-107;hsa-miR-126-5p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-944 15 SDPR Sponge network -3.855 0 -4.377 0 0.65
5 FENDRR hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-335-3p;hsa-miR-421;hsa-miR-511-5p;hsa-miR-590-3p;hsa-miR-944 10 SDPR Sponge network -4.793 0 -4.377 0 0.642
6 HAND2-AS1 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-590-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-944 15 SDPR Sponge network -5.605 0 -4.377 0 0.632
7 AF131217.1 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-421;hsa-miR-511-5p;hsa-miR-590-3p;hsa-miR-944 11 SDPR Sponge network -5.31 0 -4.377 0 0.586
8 RP11-887P2.5 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-511-5p;hsa-miR-590-5p;hsa-miR-944 11 SDPR Sponge network -6.751 0 -4.377 0 0.579
9 LINC00702 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p;hsa-miR-92b-3p 15 SDPR Sponge network -2.704 0 -4.377 0 0.569
10 RP11-805I24.3 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-511-5p;hsa-miR-944 10 SDPR Sponge network -5.815 0 -4.377 0 0.564
11 ACTA2-AS1 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-590-3p;hsa-miR-944 10 SDPR Sponge network -3.838 0 -4.377 0 0.555
12 RP11-531A24.5 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-944 12 SDPR Sponge network -1.752 0 -4.377 0 0.49
13 RP11-389G6.3 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-33a-3p;hsa-miR-511-5p;hsa-miR-590-3p;hsa-miR-944 10 SDPR Sponge network -7.573 0 -4.377 0 0.483
14 GAS6-AS2 hsa-miR-107;hsa-miR-126-5p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-421;hsa-miR-590-5p;hsa-miR-92a-3p 10 SDPR Sponge network -2.655 0 -4.377 0 0.477
15 NR2F1-AS1 hsa-miR-107;hsa-miR-126-5p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-590-3p;hsa-miR-92a-3p;hsa-miR-944 12 SDPR Sponge network -1.881 0 -4.377 0 0.474
16 RP11-401P9.4 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-511-5p;hsa-miR-590-5p;hsa-miR-944 12 SDPR Sponge network -2.738 0 -4.377 0 0.439
17 TP73-AS1 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-92a-3p 10 SDPR Sponge network -1.97 0 -4.377 0 0.423
18 RP11-456K23.1 hsa-miR-107;hsa-miR-126-5p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p 10 SDPR Sponge network -1.962 1.0E-5 -4.377 0 0.392
19 RP11-6O2.3 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-335-3p;hsa-miR-511-5p;hsa-miR-590-5p;hsa-miR-944 10 SDPR Sponge network -4.533 0 -4.377 0 0.352
20 SNHG14 hsa-miR-107;hsa-miR-142-3p;hsa-miR-186-5p;hsa-miR-32-5p;hsa-miR-339-5p;hsa-miR-421;hsa-miR-511-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p;hsa-miR-92b-3p 11 SDPR Sponge network -2.055 0 -4.377 0 0.346
21 LINC00654 hsa-miR-107;hsa-miR-126-5p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-511-5p;hsa-miR-590-3p;hsa-miR-92a-3p;hsa-miR-944 11 SDPR Sponge network -1.448 0.00044 -4.377 0 0.346
22 RP11-392O17.1 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-590-3p;hsa-miR-92a-3p 10 SDPR Sponge network -5.531 0 -4.377 0 0.327
23 AC093627.10 hsa-miR-107;hsa-miR-126-5p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-339-5p;hsa-miR-421;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p 11 SDPR Sponge network -2.338 8.0E-5 -4.377 0 0.318
24 LINC00327 hsa-miR-107;hsa-miR-126-5p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-590-3p;hsa-miR-944 10 SDPR Sponge network -1.951 0.01135 -4.377 0 0.315
25 RP11-356J5.12 hsa-miR-107;hsa-miR-126-5p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p 11 SDPR Sponge network -2.015 0 -4.377 0 0.282
26 PART1 hsa-miR-107;hsa-miR-126-5p;hsa-miR-142-3p;hsa-miR-144-3p;hsa-miR-186-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-511-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p;hsa-miR-92b-3p 13 SDPR Sponge network -3.06 7.0E-5 -4.377 0 0.279
27 RP1-151F17.2 hsa-miR-107;hsa-miR-126-5p;hsa-miR-186-5p;hsa-miR-29b-2-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p 11 SDPR Sponge network -1.606 0 -4.377 0 0.272
28 TPTEP1 hsa-miR-107;hsa-miR-142-3p;hsa-miR-186-5p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-339-5p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-511-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p;hsa-miR-92b-3p 13 SDPR Sponge network -2.267 2.0E-5 -4.377 0 0.259

Quest ID: 199e84032f1a1ae83e7579306b81a99f