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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-3p ACTL6A 0.17 0.43183 0.81 0 MirTarget -0.13 0.00031 NA
2 hsa-let-7a-3p ACTR3 0.17 0.43183 0.28 0.01178 MirTarget; miRNATAP -0.12 2.0E-5 NA
3 hsa-miR-20a-3p ANKRD1 2.52 0 -6.15 0 MirTarget -0.38 0.00024 NA
4 hsa-miR-375 ANKRD1 0.62 0.1492 -6.15 0 miRNAWalker2 validate -0.25 0.00017 NA
5 hsa-let-7a-3p ARL1 0.17 0.43183 0.22 0.06171 miRNATAP -0.11 0.00026 NA
6 hsa-let-7a-3p ARL5A 0.17 0.43183 -0.17 0.1629 MirTarget; mirMAP -0.11 0.00015 NA
7 hsa-let-7a-3p ASPH 0.17 0.43183 0.49 0.08366 mirMAP -0.15 0.02505 NA
8 hsa-let-7a-3p ASXL2 0.17 0.43183 -0.3 0.12837 mirMAP; miRNATAP -0.14 0.00544 NA
9 hsa-let-7a-3p ATAD5 0.17 0.43183 1.78 0 MirTarget -0.13 0.02804 NA
10 hsa-let-7a-3p ATE1 0.17 0.43183 -0.47 0.01177 mirMAP -0.15 0.00107 NA
11 hsa-let-7a-3p ATF1 0.17 0.43183 -0.1 0.43169 MirTarget -0.15 0 NA
12 hsa-let-7a-3p ATF2 0.17 0.43183 0.01 0.93689 MirTarget; mirMAP; miRNATAP -0.13 0.0001 NA
13 hsa-let-7a-3p ATP13A3 0.17 0.43183 0.41 0.00634 mirMAP -0.13 0.00056 NA
14 hsa-let-7a-3p ATP2B1 0.17 0.43183 -0.52 0.00592 MirTarget; miRNATAP -0.1 0.02775 NA
15 hsa-let-7a-3p BACH1 0.17 0.43183 -0.38 0.00633 MirTarget; mirMAP -0.12 0.00025 NA
16 hsa-let-7a-3p BAG4 0.17 0.43183 -0.09 0.6048 mirMAP -0.15 0.00045 NA
17 hsa-let-7a-3p BMP2K 0.17 0.43183 -0.41 0.01747 mirMAP -0.1 0.01612 NA
18 hsa-let-7a-3p BRIP1 0.17 0.43183 2.42 0 MirTarget -0.24 0.0016 NA
19 hsa-let-7a-3p BST1 0.17 0.43183 -1.69 0 MirTarget -0.15 0.01114 NA
20 hsa-let-7a-3p C1QBP 0.17 0.43183 0.43 0.00668 MirTarget -0.12 0.00264 NA
21 hsa-let-7a-3p C2orf49 0.17 0.43183 0.44 0.00033 mirMAP -0.13 1.0E-5 NA
22 hsa-let-7a-3p C4orf32 0.17 0.43183 -1.32 0 mirMAP -0.12 0.00913 NA
23 hsa-let-7a-3p CACNA2D1 0.17 0.43183 -1.27 0.00469 mirMAP -0.25 0.02505 NA
24 hsa-let-7a-3p CALCB 0.17 0.43183 0.77 0.21301 mirMAP -0.35 0.02089 NA
25 hsa-let-7a-3p CAND1 0.17 0.43183 0.38 0.00711 MirTarget; mirMAP -0.11 0.00156 NA
26 hsa-let-7a-3p CAPZA2 0.17 0.43183 -0.44 0.00975 MirTarget -0.18 2.0E-5 NA
27 hsa-let-7a-3p CCNA2 0.17 0.43183 2.69 0 MirTarget -0.23 0.00207 NA
28 hsa-let-7a-3p CCNE2 0.17 0.43183 2.15 0 mirMAP -0.22 0.00307 NA
29 hsa-let-7a-3p CEP76 0.17 0.43183 0.44 0.0025 MirTarget -0.15 3.0E-5 NA
30 hsa-let-7a-3p COL4A1 0.17 0.43183 -0.17 0.44496 miRNATAP -0.12 0.03103 NA
31 hsa-let-7a-3p CORO1C 0.17 0.43183 -1.11 0 MirTarget; miRNATAP -0.14 0.00015 NA
32 hsa-let-7a-3p CPD 0.17 0.43183 0.91 9.0E-5 mirMAP; miRNATAP -0.23 7.0E-5 NA
33 hsa-let-7a-3p CXADR 0.17 0.43183 -0.22 0.35808 miRNATAP -0.16 0.00611 NA
34 hsa-let-7a-3p CYP1B1 0.17 0.43183 -0.3 0.28599 mirMAP -0.14 0.03711 NA
35 hsa-let-7a-3p DCUN1D1 0.17 0.43183 0.14 0.30132 mirMAP -0.12 0.00032 NA
36 hsa-let-7a-3p DENND1B 0.17 0.43183 0.31 0.07298 mirMAP -0.12 0.00576 NA
37 hsa-let-7a-3p DEPDC1 0.17 0.43183 3.45 0 mirMAP -0.31 0.00111 NA
38 hsa-let-7a-3p DR1 0.17 0.43183 -0.02 0.85269 MirTarget -0.13 1.0E-5 NA
39 hsa-let-7a-3p E2F8 0.17 0.43183 3.42 0 MirTarget -0.19 0.01388 NA
40 hsa-let-7a-3p EIF2AK2 0.17 0.43183 0.62 9.0E-5 MirTarget -0.11 0.00438 NA
41 hsa-let-7a-3p ELOVL2 0.17 0.43183 0.7 0.05587 miRNATAP -0.21 0.01727 NA
42 hsa-let-7a-3p ELOVL6 0.17 0.43183 0.82 0.02787 mirMAP -0.26 0.00415 NA
43 hsa-let-7a-3p ELOVL7 0.17 0.43183 -0.31 0.30162 miRNATAP -0.17 0.01825 NA
44 hsa-let-7a-3p ENPP4 0.17 0.43183 -0.72 0.00013 mirMAP -0.1 0.02691 NA
45 hsa-let-7a-3p ESRP1 0.17 0.43183 1.06 0 MirTarget -0.1 0.03244 NA
46 hsa-let-7a-3p EVI2A 0.17 0.43183 -0.97 9.0E-5 MirTarget -0.15 0.01249 NA
47 hsa-let-7a-3p EXO1 0.17 0.43183 3.42 0 MirTarget -0.24 0.00703 NA
48 hsa-let-7a-3p FAM126A 0.17 0.43183 0.13 0.58359 MirTarget -0.18 0.00181 NA
49 hsa-let-7a-3p FAM199X 0.17 0.43183 0.79 0 MirTarget; miRNATAP -0.1 0.00218 NA
50 hsa-let-7a-3p FGF12 0.17 0.43183 -0.54 0.24373 MirTarget -0.25 0.02605 NA
51 hsa-let-7a-3p FOXN2 0.17 0.43183 -0.36 0.00692 MirTarget; miRNATAP -0.15 0 NA
52 hsa-let-7a-3p FRMD3 0.17 0.43183 -3.32 0 mirMAP; miRNATAP -0.22 0.00785 NA
53 hsa-let-7a-3p FUT4 0.17 0.43183 0.11 0.54891 mirMAP -0.12 0.0065 NA
54 hsa-let-7a-3p FZD5 0.17 0.43183 -0.71 0.00011 miRNATAP -0.12 0.00992 NA
55 hsa-let-7a-3p GDF11 0.17 0.43183 0.03 0.87092 mirMAP -0.11 0.0137 NA
56 hsa-let-7a-3p GDPD1 0.17 0.43183 0.78 0.00033 MirTarget -0.17 0.00192 NA
57 hsa-let-7a-3p GLDC 0.17 0.43183 1.59 0.0024 MirTarget -0.32 0.01281 NA
58 hsa-let-7a-3p GLS 0.17 0.43183 -0.28 0.29676 miRNATAP -0.17 0.0081 NA
59 hsa-let-7a-3p GNA13 0.17 0.43183 -0.13 0.24913 MirTarget -0.12 1.0E-5 NA
60 hsa-let-7a-3p GPRIN3 0.17 0.43183 -1.1 3.0E-5 MirTarget; mirMAP -0.22 0.0007 NA
61 hsa-let-7a-3p GSTCD 0.17 0.43183 0.42 0.00333 mirMAP -0.11 0.00189 NA
62 hsa-let-7a-3p GTF2A1 0.17 0.43183 -0.14 0.4882 MirTarget; miRNATAP -0.14 0.00426 NA
63 hsa-let-7a-3p GXYLT1 0.17 0.43183 -0.11 0.37942 mirMAP -0.11 0.00065 NA
64 hsa-let-7a-3p HCFC2 0.17 0.43183 -0.62 0 miRNATAP -0.12 0.00011 NA
65 hsa-let-7a-3p HFE 0.17 0.43183 -0.05 0.81838 mirMAP -0.13 0.01075 NA
66 hsa-let-7a-3p HGF 0.17 0.43183 -1.47 2.0E-5 mirMAP -0.22 0.00866 NA
67 hsa-let-7a-3p HOXC8 0.17 0.43183 1 0.08388 miRNATAP -0.31 0.02966 NA
68 hsa-let-7a-3p ID2 0.17 0.43183 -1.25 0 miRNATAP -0.14 0.01058 NA
69 hsa-let-7a-3p IGFBP1 0.17 0.43183 0.07 0.91515 MirTarget -0.34 0.0324 NA
70 hsa-let-7a-3p IL6ST 0.17 0.43183 -1.4 0 mirMAP -0.18 0.01237 NA
71 hsa-let-7a-3p IMPAD1 0.17 0.43183 0.09 0.48168 MirTarget -0.13 7.0E-5 NA
72 hsa-let-7a-3p IPMK 0.17 0.43183 -0.02 0.93735 mirMAP -0.26 2.0E-5 NA
73 hsa-let-7a-3p ITM2C 0.17 0.43183 0.98 0 MirTarget -0.18 0.00015 NA
74 hsa-let-7a-3p KBTBD8 0.17 0.43183 -0.82 0.00029 mirMAP -0.14 0.01084 NA
75 hsa-let-7a-3p KRAS 0.17 0.43183 0.54 0.00142 mirMAP; miRNATAP -0.17 5.0E-5 24727325; 20603437; 24890702; 23324806; 21994416; 23167843; 27620744; 20177422; 25183481; 22584434; 18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility
76 hsa-let-7a-3p LARP4 0.17 0.43183 0.16 0.18031 mirMAP -0.11 0.00024 NA
77 hsa-let-7a-3p LCOR 0.17 0.43183 0.64 0.00374 mirMAP; miRNATAP -0.14 0.01197 NA
78 hsa-let-7a-3p LEPROTL1 0.17 0.43183 -0.34 0.00372 mirMAP -0.1 0.0004 NA
79 hsa-let-7a-3p LIMS1 0.17 0.43183 -0.7 0.00015 mirMAP -0.15 0.00066 NA
80 hsa-let-7a-3p LIN7A 0.17 0.43183 -3.21 0 mirMAP -0.18 0.04728 NA
81 hsa-let-7a-3p LIN9 0.17 0.43183 0.6 0.00021 MirTarget; miRNATAP -0.11 0.00694 NA
82 hsa-let-7a-3p LRRC40 0.17 0.43183 0.14 0.26738 mirMAP -0.11 0.0003 NA
83 hsa-let-7a-3p MAN1A1 0.17 0.43183 -1.14 0 MirTarget -0.21 0.00038 NA
84 hsa-let-7a-3p MAP4K3 0.17 0.43183 0.22 0.05375 mirMAP -0.13 0 NA
85 hsa-let-7a-3p MAPK8 0.17 0.43183 0.06 0.66834 mirMAP -0.16 1.0E-5 NA
86 hsa-let-7a-3p MARCH1 0.17 0.43183 -0.82 0.00063 miRNATAP -0.2 0.00078 NA
87 hsa-let-7a-3p MGAT4A 0.17 0.43183 -0.48 0.00556 mirMAP -0.2 0 NA
88 hsa-let-7a-3p MTBP 0.17 0.43183 1.75 0 MirTarget -0.13 0.02532 NA
89 hsa-let-7a-3p MYBL1 0.17 0.43183 1.05 4.0E-5 mirMAP; miRNATAP -0.2 0.00148 NA
90 hsa-let-7a-3p N4BP2 0.17 0.43183 0.36 0.10253 mirMAP -0.16 0.00296 NA
91 hsa-let-7a-3p NEDD1 0.17 0.43183 0.21 0.09541 mirMAP -0.11 0.00026 NA
92 hsa-let-7a-3p NR5A2 0.17 0.43183 -1.64 0 miRNATAP -0.23 0.00018 NA
93 hsa-let-7a-3p NRIP1 0.17 0.43183 0.06 0.72299 miRNATAP -0.13 0.00144 NA
94 hsa-let-7a-3p NRP1 0.17 0.43183 -0.4 0.03773 miRNATAP -0.16 0.00065 NA
95 hsa-let-7a-3p OSBPL8 0.17 0.43183 -0.27 0.03621 mirMAP; miRNATAP -0.13 4.0E-5 NA
96 hsa-let-7a-3p PAFAH1B2 0.17 0.43183 -0.29 0.08784 mirMAP -0.12 0.00305 NA
97 hsa-let-7a-3p PAQR3 0.17 0.43183 0.33 0.06026 mirMAP -0.12 0.00695 NA
98 hsa-let-7a-3p PCNP 0.17 0.43183 -0.24 0.01846 MirTarget -0.1 4.0E-5 NA
99 hsa-let-7a-3p PECR 0.17 0.43183 -0.65 0.00191 MirTarget -0.13 0.01498 NA
100 hsa-let-7a-3p PEG10 0.17 0.43183 -1.59 0.0041 mirMAP -0.31 0.02191 NA
101 hsa-let-7a-3p PM20D2 0.17 0.43183 0.61 0.00034 MirTarget -0.14 0.00049 NA
102 hsa-let-7a-3p POU6F2 0.17 0.43183 2.07 0.00226 mirMAP -0.39 0.02019 NA
103 hsa-let-7a-3p PPP1CC 0.17 0.43183 0.15 0.17274 mirMAP -0.13 0 NA
104 hsa-let-7a-3p PPP1R12A 0.17 0.43183 -0.1 0.37285 mirMAP; miRNATAP -0.11 0.00013 NA
105 hsa-let-7a-3p PRKACB 0.17 0.43183 -0.34 0.09562 MirTarget; mirMAP; miRNATAP -0.11 0.02643 NA
106 hsa-let-7a-3p PRKAR2A 0.17 0.43183 -0.54 0.00821 mirMAP -0.13 0.00965 NA
107 hsa-let-7a-3p RAB10 0.17 0.43183 0.36 0.00295 MirTarget; miRNATAP -0.14 0 NA
108 hsa-let-7a-3p RAB2A 0.17 0.43183 0.33 0.00781 miRNATAP -0.1 0.00055 NA
109 hsa-let-7a-3p RAB8B 0.17 0.43183 -1.15 0 mirMAP -0.13 0.00164 NA
110 hsa-let-7a-3p RAD21 0.17 0.43183 0.11 0.4299 miRNATAP -0.14 9.0E-5 NA
111 hsa-let-7a-3p RALGPS2 0.17 0.43183 1.69 0 mirMAP -0.13 0.02068 NA
112 hsa-let-7a-3p RFC3 0.17 0.43183 0.68 0.00022 MirTarget -0.13 0.00463 NA
113 hsa-let-7a-3p RHOBTB3 0.17 0.43183 0.18 0.43653 MirTarget -0.13 0.02454 NA
114 hsa-let-7a-3p RHPN2 0.17 0.43183 0.91 0.0003 MirTarget -0.12 0.0474 NA
115 hsa-let-7a-3p RNF2 0.17 0.43183 0.36 0.00384 MirTarget; miRNATAP -0.12 8.0E-5 NA
116 hsa-let-7a-3p RNF34 0.17 0.43183 0.57 0 miRNATAP -0.1 2.0E-5 NA
117 hsa-let-7a-3p ROCK2 0.17 0.43183 -0.47 0.00661 mirMAP -0.15 0.00039 NA
118 hsa-let-7a-3p RSPO3 0.17 0.43183 -1.66 0.00014 MirTarget -0.25 0.01879 NA
119 hsa-let-7a-3p SBNO1 0.17 0.43183 0.22 0.25959 mirMAP; miRNATAP -0.14 0.00271 NA
120 hsa-let-7a-3p SEC24A 0.17 0.43183 0.56 2.0E-5 mirMAP -0.11 0.00091 NA
121 hsa-let-7a-3p SGMS1 0.17 0.43183 -0.84 0 mirMAP -0.16 0.00031 NA
122 hsa-let-7a-3p SGTB 0.17 0.43183 -0.51 0.00034 MirTarget; miRNATAP -0.11 0.00118 NA
123 hsa-let-7a-3p SLC25A40 0.17 0.43183 0.06 0.70729 mirMAP -0.13 0.00087 NA
124 hsa-let-7a-3p SLC36A4 0.17 0.43183 0.49 0.00274 mirMAP -0.12 0.00218 NA
125 hsa-let-7a-3p SNAI1 0.17 0.43183 -0.76 0.00279 miRNATAP -0.15 0.01905 NA
126 hsa-let-7a-3p SNX10 0.17 0.43183 -0.99 5.0E-5 mirMAP -0.19 0.00148 NA
127 hsa-let-7a-3p SNX9 0.17 0.43183 0.42 0.00146 miRNATAP -0.11 0.00058 NA
128 hsa-let-7a-3p SPIN4 0.17 0.43183 0 0.98692 mirMAP -0.12 0.01355 NA
129 hsa-let-7a-3p ST6GALNAC3 0.17 0.43183 -2.43 0 MirTarget -0.15 0.02731 NA
130 hsa-let-7a-3p STRN 0.17 0.43183 -0.16 0.38417 mirMAP -0.18 7.0E-5 NA
131 hsa-let-7a-3p TAOK1 0.17 0.43183 -0.16 0.47617 MirTarget; miRNATAP -0.17 0.00169 NA
132 hsa-let-7a-3p TBC1D15 0.17 0.43183 -0.57 0 MirTarget; miRNATAP -0.1 0.00012 NA
133 hsa-let-7a-3p TFAM 0.17 0.43183 0.5 0.00027 MirTarget; mirMAP -0.15 1.0E-5 NA
134 hsa-let-7a-3p TFRC 0.17 0.43183 -1.38 0 mirMAP -0.18 0.00183 NA
135 hsa-let-7a-3p TMEM39A 0.17 0.43183 0.29 0.00835 MirTarget; miRNATAP -0.12 2.0E-5 NA
136 hsa-let-7a-3p TMEM55A 0.17 0.43183 -0.5 0.00898 mirMAP -0.17 0.00033 NA
137 hsa-let-7a-3p TMPO 0.17 0.43183 0.53 0.00157 mirMAP -0.2 0 NA
138 hsa-let-7a-3p TMTC3 0.17 0.43183 0.2 0.18675 MirTarget -0.1 0.00574 NA
139 hsa-let-7a-3p TRERF1 0.17 0.43183 0.44 0.0354 mirMAP -0.17 0.00091 NA
140 hsa-let-7a-3p TSC22D2 0.17 0.43183 -0.39 0.03383 MirTarget; mirMAP -0.17 0.00014 NA
141 hsa-let-7a-3p TTC5 0.17 0.43183 -0.15 0.31066 mirMAP -0.12 0.00097 NA
142 hsa-let-7a-3p UBE2Q2 0.17 0.43183 -0.2 0.09862 MirTarget -0.11 0.00015 NA
143 hsa-let-7a-3p UBE2W 0.17 0.43183 0.51 0.00062 MirTarget; mirMAP; miRNATAP -0.14 0.0002 NA
144 hsa-let-7a-3p UGT3A1 0.17 0.43183 -0.11 0.87391 mirMAP -0.47 0.00438 NA
145 hsa-let-7a-3p UHMK1 0.17 0.43183 0.25 0.3197 MirTarget; mirMAP -0.2 0.00119 NA
146 hsa-let-7a-3p USP12 0.17 0.43183 -1.07 0 MirTarget; mirMAP; miRNATAP -0.12 0.00361 NA
147 hsa-let-7a-3p USP37 0.17 0.43183 0.57 0 mirMAP -0.11 0.0002 NA
148 hsa-let-7a-3p VCAN 0.17 0.43183 0.99 0.00135 MirTarget -0.15 0.04666 NA
149 hsa-let-7a-3p VIL1 0.17 0.43183 4.78 0 mirMAP -1.07 1.0E-5 NA
150 hsa-let-7a-3p VPS37A 0.17 0.43183 0.06 0.71911 MirTarget -0.13 0.00133 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 cGMP_PKG_signaling_pathway_hsa04022 6 163 0.001956 0.04396
2 MAPK_signaling_pathway_hsa04010 8 295 0.002534 0.04396
3 Sphingolipid_signaling_pathway_hsa04071 5 118 0.002536 0.04396
4 cAMP_signaling_pathway_hsa04024 6 198 0.005098 0.05432
5 Focal_adhesion_hsa04510 6 199 0.005223 0.05432
6 Cellular_senescence_hsa04218 5 160 0.009126 0.07909
7 Tight_junction_hsa04530 5 170 0.01165 0.08655
8 Mitophagy_animal_hsa04137 3 65 0.01503 0.0977
9 Apelin_signaling_pathway_hsa04371 4 137 0.02393 0.1205
10 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 4 139 0.02507 0.1205
11 Regulation_of_actin_cytoskeleton_hsa04810 5 208 0.02548 0.1205
12 Wnt_signaling_pathway_hsa04310 4 146 0.02932 0.127
13 TNF_signaling_pathway_hsa04668 3 108 0.05502 0.2201
14 AMPK_signaling_pathway_hsa04152 3 121 0.07214 0.2483
15 Cell_cycle_hsa04110 3 124 0.0764 0.2483
16 Oocyte_meiosis_hsa04114 3 124 0.0764 0.2483
17 Autophagy_animal_hsa04140 3 128 0.08224 0.2515
18 Ras_signaling_pathway_hsa04014 4 232 0.1141 0.3295
19 Hippo_signaling_pathway_hsa04390 3 154 0.1245 0.3387
20 Endocytosis_hsa04144 4 244 0.1303 0.3387
21 ErbB_signaling_pathway_hsa04012 2 85 0.1467 0.3505
22 PI3K_Akt_signaling_pathway_hsa04151 5 352 0.1496 0.3505
23 Gap_junction_hsa04540 2 88 0.155 0.3505
24 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.1861 0.4031
25 FoxO_signaling_pathway_hsa04068 2 132 0.2825 0.5441
26 Apoptosis_hsa04210 2 138 0.3002 0.5574
27 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.3236 0.5608
28 mTOR_signaling_pathway_hsa04150 2 151 0.3381 0.5671
29 Necroptosis_hsa04217 2 164 0.3754 0.5925
30 Calcium_signaling_pathway_hsa04020 2 182 0.4255 0.6322
31 Rap1_signaling_pathway_hsa04015 2 206 0.489 0.636
32 Cytokine_cytokine_receptor_interaction_hsa04060 2 270 0.6353 0.7866

Quest ID: 1f6022092eff27e994c72116c8201800