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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-129-5p ABCD1 0.57 0.00116 -0.29 0 MirTarget -0.14 0 NA
2 hsa-miR-129-5p ADAM12 0.57 0.00116 -1.04 0 miRanda; mirMAP -0.18 0 NA
3 hsa-miR-129-5p ADAMTS7 0.57 0.00116 -0.77 0 MirTarget -0.17 0 NA
4 hsa-miR-129-5p AGER 0.57 0.00116 0.05 0.58371 MirTarget -0.11 0 NA
5 hsa-miR-129-5p AK2 0.57 0.00116 -0.28 1.0E-5 miRanda -0.1 0 NA
6 hsa-miR-129-5p AKNAD1 0.57 0.00116 -0.78 0 miRanda -0.14 0.00011 NA
7 hsa-miR-129-5p ALDH3B1 0.57 0.00116 -0.3 0.00016 miRanda -0.11 0 NA
8 hsa-miR-129-5p ANGPT2 0.57 0.00116 -0.97 0 MirTarget; miRanda -0.32 0 NA
9 hsa-miR-129-5p ANTXR1 0.57 0.00116 -0.06 0.43139 miRanda; mirMAP -0.11 0 NA
10 hsa-miR-129-5p ANTXR2 0.57 0.00116 -0.43 0 miRanda; miRNATAP -0.12 0 NA
11 hsa-miR-129-5p ARHGAP11A 0.57 0.00116 -1.03 0 miRanda -0.14 0 NA
12 hsa-miR-129-5p ARL11 0.57 0.00116 -0.29 0.00363 miRanda; mirMAP -0.14 0 NA
13 hsa-miR-129-5p ARPC1B 0.57 0.00116 -0.33 0.00019 mirMAP -0.13 0 NA
14 hsa-miR-129-5p ASPN 0.57 0.00116 -0.54 2.0E-5 miRanda -0.1 0.00189 NA
15 hsa-miR-129-5p BAZ1A 0.57 0.00116 -0.31 1.0E-5 miRanda -0.14 0 NA
16 hsa-miR-129-5p BCHE 0.57 0.00116 0.09 0.28367 PITA; miRanda -0.13 0 NA
17 hsa-miR-129-5p BCL2L12 0.57 0.00116 -0.6 0 miRanda -0.17 0 NA
18 hsa-miR-129-5p BEST3 0.57 0.00116 0.16 0.28659 MirTarget; miRanda -0.18 0 NA
19 hsa-miR-129-5p BRCA2 0.57 0.00116 -1.03 0 miRanda; mirMAP -0.16 0 NA
20 hsa-miR-129-5p BTN2A2 0.57 0.00116 -0.55 0 miRanda -0.11 0 NA
21 hsa-miR-129-5p C1R 0.57 0.00116 -0.78 0 MirTarget; mirMAP -0.18 0 NA
22 hsa-miR-129-5p C1S 0.57 0.00116 -0.57 0 MirTarget -0.12 9.0E-5 NA
23 hsa-miR-129-5p C2 0.57 0.00116 -0.51 3.0E-5 miRanda -0.16 0 NA
24 hsa-miR-129-5p C5AR1 0.57 0.00116 -0.4 0.0018 miRanda -0.17 0 NA
25 hsa-miR-129-5p CA12 0.57 0.00116 -0.11 0.46148 miRanda; mirMAP -0.11 0.00278 NA
26 hsa-miR-129-5p CACNA2D4 0.57 0.00116 -0.12 0.22376 miRanda; mirMAP -0.16 0 NA
27 hsa-miR-129-5p CALD1 0.57 0.00116 -0.39 0 miRanda -0.11 0 NA
28 hsa-miR-129-5p CASP1 0.57 0.00116 -0.5 0 miRanda -0.16 0 NA
29 hsa-miR-129-5p CASP6 0.57 0.00116 -0.34 0 MirTarget; miRanda -0.13 0 NA
30 hsa-miR-129-5p CASP8 0.57 0.00116 -0.55 0 miRanda -0.12 0 NA
31 hsa-miR-129-5p CASZ1 0.57 0.00116 -0.06 0.59914 miRNATAP -0.12 2.0E-5 NA
32 hsa-miR-129-5p CCDC102B 0.57 0.00116 -0.13 0.01341 miRanda -0.11 0 NA
33 hsa-miR-129-5p CCDC150 0.57 0.00116 -0.72 0 miRanda -0.13 0 NA
34 hsa-miR-129-5p CCDC18 0.57 0.00116 -0.84 0 MirTarget -0.14 0 NA
35 hsa-miR-129-5p CCNA2 0.57 0.00116 -1.13 0 miRanda -0.2 0 NA
36 hsa-miR-129-5p CCND2 0.57 0.00116 -0.28 0.00231 mirMAP -0.11 0 NA
37 hsa-miR-129-5p CCR1 0.57 0.00116 -0.27 0.01955 miRanda -0.11 0.00014 NA
38 hsa-miR-129-5p CD1D 0.57 0.00116 -0.22 0.05808 miRanda -0.22 0 NA
39 hsa-miR-129-5p CD209 0.57 0.00116 0 0.99091 miRanda -0.19 1.0E-5 NA
40 hsa-miR-129-5p CD36 0.57 0.00116 -0.2 0.18077 miRanda -0.16 4.0E-5 NA
41 hsa-miR-129-5p CD3E 0.57 0.00116 -0.95 0 miRanda -0.13 0.00435 NA
42 hsa-miR-129-5p CD4 0.57 0.00116 -0.3 0.00118 MirTarget -0.13 0 NA
43 hsa-miR-129-5p CD72 0.57 0.00116 -0.3 0.00117 miRanda -0.14 0 NA
44 hsa-miR-129-5p CD93 0.57 0.00116 -0.97 0 MirTarget; miRanda -0.24 0 NA
45 hsa-miR-129-5p CDCA2 0.57 0.00116 -1.51 0 miRanda -0.24 0 NA
46 hsa-miR-129-5p CDCA7L 0.57 0.00116 -0.51 0 miRanda; mirMAP -0.14 0 NA
47 hsa-miR-129-5p CDCP1 0.57 0.00116 -0.51 1.0E-5 miRanda; mirMAP -0.14 0 NA
48 hsa-miR-129-5p CDH15 0.57 0.00116 -0.19 0.3975 MirTarget -0.16 0.00445 NA
49 hsa-miR-129-5p CDK1 0.57 0.00116 -1.31 0 miRanda -0.21 0 NA
50 hsa-miR-129-5p CDK6 0.57 0.00116 -0.51 1.0E-5 miRNAWalker2 validate -0.1 0.00025 24055727 Interestingly we showed that cyclin dependent kinase 6 CDK6 a cell cycle-associated protein involved in G1-S transition was a target of miR-129
51 hsa-miR-129-5p CDKN2C 0.57 0.00116 -0.9 0 miRanda -0.19 0 NA
52 hsa-miR-129-5p CENPF 0.57 0.00116 -1.39 0 miRanda -0.14 0.0002 NA
53 hsa-miR-129-5p CEP152 0.57 0.00116 -0.62 0 miRanda -0.12 0 NA
54 hsa-miR-129-5p CEP55 0.57 0.00116 -1.55 0 miRanda -0.3 0 NA
55 hsa-miR-129-5p CHEK1 0.57 0.00116 -0.57 0 miRanda -0.12 0 NA
56 hsa-miR-129-5p CIITA 0.57 0.00116 -0.97 0 miRanda; mirMAP -0.15 0.00014 NA
57 hsa-miR-129-5p CLEC2B 0.57 0.00116 -0.45 1.0E-5 miRanda -0.16 0 NA
58 hsa-miR-129-5p CLEC2D 0.57 0.00116 -0.05 0.4227 PITA; miRanda -0.12 0 NA
59 hsa-miR-129-5p CMKLR1 0.57 0.00116 -0.04 0.64513 miRanda -0.13 0 NA
60 hsa-miR-129-5p CMTM3 0.57 0.00116 -0.45 0 miRanda -0.19 0 NA
61 hsa-miR-129-5p CMTM6 0.57 0.00116 -0.33 0 miRanda -0.1 0 NA
62 hsa-miR-129-5p CNN3 0.57 0.00116 -0.29 0.0005 MirTarget; PITA; miRanda -0.1 0 NA
63 hsa-miR-129-5p COL14A1 0.57 0.00116 -0.79 0 miRanda -0.2 0 NA
64 hsa-miR-129-5p COL1A1 0.57 0.00116 -1.24 0 miRanda -0.38 0 NA
65 hsa-miR-129-5p COL1A2 0.57 0.00116 -0.95 0 miRanda -0.18 0 NA
66 hsa-miR-129-5p COL3A1 0.57 0.00116 -1.43 0 miRanda -0.38 0 NA
67 hsa-miR-129-5p COL4A1 0.57 0.00116 -1.37 0 miRanda -0.32 0 NA
68 hsa-miR-129-5p CP 0.57 0.00116 -0.86 6.0E-5 miRanda -0.12 0.02386 NA
69 hsa-miR-129-5p CRISPLD1 0.57 0.00116 -0.54 0 miRanda -0.18 0 NA
70 hsa-miR-129-5p CTSC 0.57 0.00116 -0.51 0 MirTarget; miRanda; mirMAP -0.17 0 NA
71 hsa-miR-129-5p CTSS 0.57 0.00116 -0.37 0.00054 miRanda -0.17 0 NA
72 hsa-miR-129-5p CYBB 0.57 0.00116 -0.21 0.09129 miRanda -0.13 5.0E-5 NA
73 hsa-miR-129-5p CYTIP 0.57 0.00116 -0.39 0.00064 miRanda -0.13 2.0E-5 NA
74 hsa-miR-129-5p DAB2 0.57 0.00116 -0.13 0.10175 MirTarget; miRanda -0.16 0 NA
75 hsa-miR-129-5p DDX11 0.57 0.00116 -0.31 0.00084 miRanda -0.14 0 NA
76 hsa-miR-129-5p DEPDC1 0.57 0.00116 -1.46 0 miRanda -0.11 0.00857 NA
77 hsa-miR-129-5p DMRTA2 0.57 0.00116 -0.74 0.00112 MirTarget; PITA; miRanda; miRNATAP -0.17 0.00355 NA
78 hsa-miR-129-5p DNAJB11 0.57 0.00116 -0.25 0 miRanda -0.1 0 NA
79 hsa-miR-129-5p DNASE1L3 0.57 0.00116 -0.26 0.16275 miRanda -0.15 0.00128 NA
80 hsa-miR-129-5p DOK3 0.57 0.00116 -0.44 0 MirTarget; miRanda -0.14 0 NA
81 hsa-miR-129-5p DPYD 0.57 0.00116 -0.61 0 miRanda -0.15 0 NA
82 hsa-miR-129-5p DSE 0.57 0.00116 -0.28 0 MirTarget; miRanda; miRNATAP -0.11 0 NA
83 hsa-miR-129-5p DTL 0.57 0.00116 -1.27 0 miRanda; miRNATAP -0.2 0 NA
84 hsa-miR-129-5p DUOXA1 0.57 0.00116 0.05 0.7645 MirTarget -0.12 0.0031 NA
85 hsa-miR-129-5p E2F7 0.57 0.00116 -1.47 0 PITA; miRanda; miRNATAP -0.2 0 NA
86 hsa-miR-129-5p EDA2R 0.57 0.00116 -0.39 0.03144 PITA; miRanda -0.13 0.00617 NA
87 hsa-miR-129-5p EDNRA 0.57 0.00116 -0.2 0.0673 miRanda; mirMAP -0.16 0 NA
88 hsa-miR-129-5p EHD4 0.57 0.00116 -0.48 0 miRanda; mirMAP -0.13 0 NA
89 hsa-miR-129-5p EME1 0.57 0.00116 -0.84 0 MirTarget; miRanda; miRNATAP -0.18 0 NA
90 hsa-miR-129-5p EMP1 0.57 0.00116 -0.48 0.00071 miRanda -0.13 0.00014 NA
91 hsa-miR-129-5p ENPEP 0.57 0.00116 -0.99 0 miRanda -0.26 0 NA
92 hsa-miR-129-5p ERCC6L 0.57 0.00116 -1.1 0 miRNATAP -0.17 0 NA
93 hsa-miR-129-5p ERI1 0.57 0.00116 -0.28 0 miRanda -0.11 0 NA
94 hsa-miR-129-5p ESCO2 0.57 0.00116 -1.34 0 miRanda -0.19 0 NA
95 hsa-miR-129-5p ETV1 0.57 0.00116 0.13 0.31231 MirTarget; PITA; miRanda; miRNATAP -0.12 7.0E-5 NA
96 hsa-miR-129-5p ETV6 0.57 0.00116 -0.33 0 miRNAWalker2 validate; MirTarget; miRanda; miRNATAP -0.1 0 NA
97 hsa-miR-129-5p F2R 0.57 0.00116 -0.4 4.0E-5 MirTarget; miRanda; mirMAP -0.19 0 NA
98 hsa-miR-129-5p F2RL2 0.57 0.00116 -0.9 0 MirTarget -0.13 0.00594 NA
99 hsa-miR-129-5p FABP4 0.57 0.00116 -0.27 0.10606 miRanda -0.19 1.0E-5 NA
100 hsa-miR-129-5p FADD 0.57 0.00116 -0.22 0 miRanda -0.1 0 NA
101 hsa-miR-129-5p FAM111B 0.57 0.00116 -1.39 0 PITA; miRanda; mirMAP -0.27 0 NA
102 hsa-miR-129-5p FAM129A 0.57 0.00116 -0.87 0 mirMAP -0.17 0 NA
103 hsa-miR-129-5p FAM20A 0.57 0.00116 -1.06 0 miRanda -0.14 0.00016 NA
104 hsa-miR-129-5p FAM46A 0.57 0.00116 -0.5 0 PITA; miRanda -0.2 0 NA
105 hsa-miR-129-5p FAM60A 0.57 0.00116 -0.26 0.00567 miRanda -0.18 0 NA
106 hsa-miR-129-5p FAM95B1 0.57 0.00116 -0.53 8.0E-5 miRanda -0.12 9.0E-5 NA
107 hsa-miR-129-5p FAM96A 0.57 0.00116 -0.18 5.0E-5 miRanda -0.1 0 NA
108 hsa-miR-129-5p FANCD2 0.57 0.00116 -0.87 0 miRanda -0.14 0 NA
109 hsa-miR-129-5p FANCI 0.57 0.00116 -0.88 0 MirTarget; miRanda -0.13 0 NA
110 hsa-miR-129-5p FBLIM1 0.57 0.00116 -0.75 0 miRanda -0.16 0 NA
111 hsa-miR-129-5p FBN2 0.57 0.00116 -0.1 0.51337 miRanda -0.16 0.00011 NA
112 hsa-miR-129-5p FBXO43 0.57 0.00116 -0.45 0 miRanda -0.15 0 NA
113 hsa-miR-129-5p FNDC3B 0.57 0.00116 -0.48 0 miRNAWalker2 validate; miRanda; miRNATAP -0.12 0 NA
114 hsa-miR-129-5p FOXD1 0.57 0.00116 -0.79 0 miRanda -0.21 0 NA
115 hsa-miR-129-5p FOXD3 0.57 0.00116 -0.99 4.0E-5 miRanda -0.29 0 NA
116 hsa-miR-129-5p FREM2 0.57 0.00116 -0.91 0 mirMAP -0.13 0.00301 NA
117 hsa-miR-129-5p FST 0.57 0.00116 -0.58 2.0E-5 MirTarget; miRanda -0.1 0.00379 NA
118 hsa-miR-129-5p GADD45A 0.57 0.00116 -0.58 0 miRanda -0.12 0 NA
119 hsa-miR-129-5p GALNT5 0.57 0.00116 -1.32 0 miRanda -0.17 0.0021 NA
120 hsa-miR-129-5p GAS1 0.57 0.00116 -0.71 0 miRanda -0.11 0 NA
121 hsa-miR-129-5p GEM 0.57 0.00116 -0.59 0 miRanda -0.13 9.0E-5 NA
122 hsa-miR-129-5p GEN1 0.57 0.00116 -0.37 0 miRanda; mirMAP -0.1 0 NA
123 hsa-miR-129-5p GINS3 0.57 0.00116 0.02 0.81508 MirTarget; miRanda -0.11 0 NA
124 hsa-miR-129-5p GINS4 0.57 0.00116 -0.65 0 miRanda -0.12 0 NA
125 hsa-miR-129-5p GLIS3 0.57 0.00116 -0.22 0.06581 miRanda; mirMAP -0.11 0.0002 NA
126 hsa-miR-129-5p GMFG 0.57 0.00116 -0.35 2.0E-5 miRanda -0.11 0 NA
127 hsa-miR-129-5p GNAI3 0.57 0.00116 -0.2 0.00127 miRanda -0.11 0 NA
128 hsa-miR-129-5p GPNMB 0.57 0.00116 -0.61 0.00028 miRanda -0.23 0 NA
129 hsa-miR-129-5p GPR82 0.57 0.00116 -1.43 0 miRanda; mirMAP -0.36 0 NA
130 hsa-miR-129-5p GPRC5A 0.57 0.00116 -1.16 0 miRanda -0.15 0.00187 NA
131 hsa-miR-129-5p GPX7 0.57 0.00116 -0.52 0 miRanda -0.11 0 NA
132 hsa-miR-129-5p GPX8 0.57 0.00116 -1.16 0 miRanda -0.18 0 NA
133 hsa-miR-129-5p GRHL3 0.57 0.00116 0.61 0.00011 miRanda -0.17 2.0E-5 NA
134 hsa-miR-129-5p HAND2 0.57 0.00116 -1.67 0 miRanda -0.25 0.00048 NA
135 hsa-miR-129-5p HAS3 0.57 0.00116 -0.25 0.0003 mirMAP -0.1 0 NA
136 hsa-miR-129-5p HAUS5 0.57 0.00116 -0.33 0 miRanda -0.11 0 NA
137 hsa-miR-129-5p HAVCR2 0.57 0.00116 -0.24 0.03266 miRanda -0.11 6.0E-5 NA
138 hsa-miR-129-5p HLA-DMB 0.57 0.00116 -0.56 0 miRanda; mirMAP -0.16 0 NA
139 hsa-miR-129-5p HLA-DQA1 0.57 0.00116 -1.23 0 miRanda -0.21 4.0E-5 NA
140 hsa-miR-129-5p HLA-DQA2 0.57 0.00116 -1.29 0 miRanda -0.19 0.0012 NA
141 hsa-miR-129-5p HLA-F 0.57 0.00116 -0.51 0 miRanda -0.11 0 NA
142 hsa-miR-129-5p HMGA2 0.57 0.00116 -1.16 0 miRanda; mirMAP -0.18 0.00135 NA
143 hsa-miR-129-5p HOXA11 0.57 0.00116 -1.36 0 miRanda -0.26 0.00042 NA
144 hsa-miR-129-5p HOXA2 0.57 0.00116 -1.57 0 miRanda -0.28 0 NA
145 hsa-miR-129-5p HOXA3 0.57 0.00116 -1.8 0 miRanda -0.32 0 NA
146 hsa-miR-129-5p HOXA4 0.57 0.00116 -1.88 0 miRanda -0.36 0 NA
147 hsa-miR-129-5p HOXA5 0.57 0.00116 -1.75 0 miRanda; miRNATAP -0.28 3.0E-5 NA
148 hsa-miR-129-5p HOXB7 0.57 0.00116 -0.83 0 miRanda -0.32 0 NA
149 hsa-miR-129-5p HOXC10 0.57 0.00116 -1.81 0 PITA; miRanda; miRNATAP -0.2 0.00278 NA
150 hsa-miR-129-5p HOXC13 0.57 0.00116 -1.28 0 PITA; miRanda; miRNATAP -0.13 0.00973 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 IMMUNE SYSTEM PROCESS 82 1984 9.65e-16 4.49e-12
2 SKELETAL SYSTEM DEVELOPMENT 32 455 3.738e-12 4.598e-09
3 REGULATION OF IMMUNE SYSTEM PROCESS 60 1403 3.953e-12 4.598e-09
4 REGULATION OF CELL PROLIFERATION 63 1496 1.998e-12 4.598e-09
5 POSITIVE REGULATION OF GENE EXPRESSION 68 1733 5.652e-12 5.26e-09
6 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 69 1805 1.251e-11 9.699e-09
7 CARTILAGE DEVELOPMENT 18 147 3.185e-11 1.964e-08
8 TISSUE DEVELOPMENT 61 1518 3.378e-11 1.964e-08
9 CONNECTIVE TISSUE DEVELOPMENT 20 194 6.079e-11 3.143e-08
10 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 43 867 7.188e-11 3.345e-08
11 IMMUNE SYSTEM DEVELOPMENT 34 582 1.225e-10 5.182e-08
12 REGULATION OF IMMUNE RESPONSE 42 858 1.833e-10 7.106e-08
13 REGULATION OF CELL ADHESION 35 629 2.397e-10 8.578e-08
14 CELL ACTIVATION 33 568 2.694e-10 8.953e-08
15 IMMUNE RESPONSE 48 1100 3.996e-10 1.24e-07
16 BIOLOGICAL ADHESION 46 1032 4.922e-10 1.431e-07
17 POSITIVE REGULATION OF RESPONSE TO STIMULUS 68 1929 6.21e-10 1.7e-07
18 RESPONSE TO EXTERNAL STIMULUS 65 1821 9.853e-10 2.547e-07
19 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 15 122 1.355e-09 3.317e-07
20 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 61 1672 1.575e-09 3.665e-07
21 SINGLE ORGANISM CELL ADHESION 28 459 2.239e-09 4.962e-07
22 DEFENSE RESPONSE 49 1231 5.4e-09 1.142e-06
23 EXTRACELLULAR STRUCTURE ORGANIZATION 22 304 5.869e-09 1.187e-06
24 LEUKOCYTE CELL CELL ADHESION 20 255 7.553e-09 1.464e-06
25 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 52 1395 1.558e-08 2.899e-06
26 LEUKOCYTE ACTIVATION 25 414 2.048e-08 3.665e-06
27 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 29 554 3.469e-08 5.704e-06
28 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 12 93 3.555e-08 5.704e-06
29 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 45 1142 3.329e-08 5.704e-06
30 REGULATION OF LEUKOCYTE PROLIFERATION 17 206 4.89e-08 7.584e-06
31 POSITIVE REGULATION OF CELL PROLIFERATION 36 814 5.501e-08 7.757e-06
32 REGULATION OF CELL DIFFERENTIATION 53 1492 5.455e-08 7.757e-06
33 CELL CYCLE PROCESS 43 1081 5.347e-08 7.757e-06
34 CELLULAR RESPONSE TO MECHANICAL STIMULUS 11 80 6.805e-08 9.313e-06
35 PATTERN SPECIFICATION PROCESS 24 418 1.019e-07 1.355e-05
36 T CELL DIFFERENTIATION 13 123 1.072e-07 1.386e-05
37 MITOTIC CELL CYCLE 34 766 1.216e-07 1.529e-05
38 REGULATION OF T CELL PROLIFERATION 14 147 1.293e-07 1.583e-05
39 SKELETAL SYSTEM MORPHOGENESIS 16 201 1.999e-07 2.385e-05
40 LYMPHOCYTE ACTIVATION 21 342 2.168e-07 2.522e-05
41 NEGATIVE REGULATION OF CELL PROLIFERATION 30 643 2.46e-07 2.792e-05
42 CELL CYCLE 47 1316 2.964e-07 3.284e-05
43 REGULATION OF CELL CELL ADHESION 22 380 3.056e-07 3.307e-05
44 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 34 801 3.442e-07 3.64e-05
45 RESPONSE TO MECHANICAL STIMULUS 16 210 3.629e-07 3.752e-05
46 REGULATION OF CELL ACTIVATION 25 484 4.062e-07 4.108e-05
47 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 39 1004 4.33e-07 4.287e-05
48 EMBRYO DEVELOPMENT 36 894 5.375e-07 5.211e-05
49 REGULATION OF CYTOKINE PRODUCTION 27 563 5.934e-07 5.635e-05
50 ANTERIOR POSTERIOR PATTERN SPECIFICATION 15 194 6.998e-07 6.385e-05
51 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 38 983 6.944e-07 6.385e-05
52 REGULATION OF HOMOTYPIC CELL CELL ADHESION 19 307 7.349e-07 6.576e-05
53 EMBRYONIC ORGAN MORPHOGENESIS 18 279 7.937e-07 6.839e-05
54 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 58 1848 7.801e-07 6.839e-05
55 CELL CELL ADHESION 28 608 8.158e-07 6.902e-05
56 POSITIVE REGULATION OF CELL ADHESION 21 376 1.021e-06 8.48e-05
57 ORGAN MORPHOGENESIS 34 841 1.041e-06 8.495e-05
58 ADAPTIVE IMMUNE RESPONSE 18 288 1.254e-06 0.0001006
59 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 49 1492 1.843e-06 0.0001453
60 EPITHELIUM DEVELOPMENT 36 945 1.955e-06 0.0001516
61 POSITIVE REGULATION OF CELL CELL ADHESION 16 243 2.511e-06 0.0001915
62 EMBRYONIC MORPHOGENESIS 25 539 2.851e-06 0.000214
63 POSITIVE REGULATION OF CYTOKINE PRODUCTION 20 370 3.046e-06 0.000225
64 RESPONSE TO NUTRIENT 14 191 3.096e-06 0.0002251
65 POSITIVE REGULATION OF T CELL PROLIFERATION 10 95 3.331e-06 0.0002384
66 RESPONSE TO LIPID 34 888 3.446e-06 0.0002393
67 EMBRYONIC ORGAN DEVELOPMENT 21 406 3.438e-06 0.0002393
68 NEGATIVE REGULATION OF GENE EXPRESSION 48 1493 4.268e-06 0.000292
69 RESPONSE TO VITAMIN 10 98 4.422e-06 0.0002982
70 POSITIVE REGULATION OF IMMUNE RESPONSE 25 563 6.104e-06 0.0004057
71 LEUKOCYTE DIFFERENTIATION 17 292 6.411e-06 0.0004202
72 REGULATION OF DEFENSE RESPONSE 30 759 7.237e-06 0.0004677
73 TISSUE MORPHOGENESIS 24 533 7.454e-06 0.0004751
74 BLOOD VESSEL MORPHOGENESIS 19 364 8.873e-06 0.0005362
75 RESPONSE TO BIOTIC STIMULUS 33 886 8.597e-06 0.0005362
76 POSITIVE REGULATION OF DEFENSE RESPONSE 19 364 8.873e-06 0.0005362
77 LYMPHOCYTE DIFFERENTIATION 14 209 8.776e-06 0.0005362
78 NEGATIVE REGULATION OF CELL CYCLE 21 433 9.247e-06 0.0005516
79 VASCULATURE DEVELOPMENT 22 469 9.556e-06 0.0005628
80 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 11 131 9.88e-06 0.0005746
81 POSITIVE REGULATION OF INTERFERON GAMMA PRODUCTION 8 65 1.007e-05 0.0005782
82 CHROMOSOME SEGREGATION 16 272 1.055e-05 0.0005985
83 NEGATIVE REGULATION OF CELL CYCLE PROCESS 14 214 1.148e-05 0.0006371
84 POSITIVE REGULATION OF LEUKOCYTE MIGRATION 10 109 1.15e-05 0.0006371
85 POSITIVE REGULATION OF CELL DIFFERENTIATION 31 823 1.313e-05 0.0007189
86 RESPONSE TO VITAMIN D 6 33 1.345e-05 0.0007193
87 G2 DNA DAMAGE CHECKPOINT 6 33 1.345e-05 0.0007193
88 POSITIVE REGULATION OF LEUKOCYTE PROLIFERATION 11 136 1.411e-05 0.0007461
89 POSITIVE REGULATION OF CELL ACTIVATION 17 311 1.461e-05 0.0007552
90 REGIONALIZATION 17 311 1.461e-05 0.0007552
91 CELL PROLIFERATION 27 672 1.581e-05 0.0008085
92 POSITIVE REGULATION OF ENDOCYTOSIS 10 114 1.709e-05 0.0008645
93 INTERFERON GAMMA MEDIATED SIGNALING PATHWAY 8 70 1.755e-05 0.0008685
94 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 32 876 1.744e-05 0.0008685
95 POSITIVE REGULATION OF CELL COMMUNICATION 47 1532 1.838e-05 0.000891
96 CELL CYCLE CHECKPOINT 13 194 1.828e-05 0.000891
97 INFLAMMATORY RESPONSE 21 454 1.88e-05 0.0009019
98 APPENDAGE DEVELOPMENT 12 169 2.159e-05 0.001015
99 LIMB DEVELOPMENT 12 169 2.159e-05 0.001015
100 REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 9 94 2.24e-05 0.001042
101 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 13 199 2.393e-05 0.001102
102 RESPONSE TO INTERFERON GAMMA 11 144 2.415e-05 0.001102
103 ACTIVATION OF IMMUNE RESPONSE 20 427 2.49e-05 0.001125
104 REGULATION OF CELLULAR COMPONENT MOVEMENT 29 771 2.59e-05 0.001159
105 REGULATION OF LEUKOCYTE CHEMOTAXIS 9 96 2.654e-05 0.001176
106 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 11 146 2.746e-05 0.001206
107 RESPONSE TO ABIOTIC STIMULUS 35 1024 2.798e-05 0.001217
108 MUSCLE STRUCTURE DEVELOPMENT 20 432 2.936e-05 0.001265
109 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 46 1517 3.044e-05 0.001269
110 CARTILAGE MORPHOGENESIS 4 12 3.057e-05 0.001269
111 INNATE IMMUNE RESPONSE 25 619 3.017e-05 0.001269
112 RESPONSE TO OXYGEN CONTAINING COMPOUND 43 1381 3.074e-05 0.001269
113 REGULATION OF CELL DEATH 45 1472 3.083e-05 0.001269
114 COLLAGEN FIBRIL ORGANIZATION 6 38 3.131e-05 0.001278
115 OUTFLOW TRACT MORPHOGENESIS 7 56 3.286e-05 0.001329
116 REGULATION OF LEUKOCYTE MIGRATION 11 149 3.317e-05 0.00133
117 UROGENITAL SYSTEM DEVELOPMENT 16 299 3.37e-05 0.00134
118 REGULATION OF PROTEIN MODIFICATION PROCESS 50 1710 3.417e-05 0.001347
119 CARDIOVASCULAR SYSTEM DEVELOPMENT 29 788 3.843e-05 0.00149
120 CIRCULATORY SYSTEM DEVELOPMENT 29 788 3.843e-05 0.00149
121 TUBE DEVELOPMENT 23 552 3.915e-05 0.001505
122 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 33 957 4.041e-05 0.001541
123 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 8 79 4.273e-05 0.001597
124 PERIPHERAL NERVOUS SYSTEM NEURON DIFFERENTIATION 4 13 4.359e-05 0.001597
125 RESPONSE TO ORGANIC CYCLIC COMPOUND 32 917 4.237e-05 0.001597
126 MITOTIC G2 DNA DAMAGE CHECKPOINT 4 13 4.359e-05 0.001597
127 PERIPHERAL NERVOUS SYSTEM NEURON DEVELOPMENT 4 13 4.359e-05 0.001597
128 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 37 1135 4.476e-05 0.001627
129 ANTIGEN PROCESSING AND PRESENTATION 13 213 4.857e-05 0.001752
130 POSITIVE REGULATION OF LEUKOCYTE CHEMOTAXIS 8 81 5.122e-05 0.001833
131 POSITIVE REGULATION OF STEM CELL PROLIFERATION 7 61 5.767e-05 0.002048
132 NEGATIVE REGULATION OF CELL DIFFERENTIATION 24 609 6.397e-05 0.002255
133 CELL DEVELOPMENT 43 1426 6.457e-05 0.002259
134 MESENCHYME DEVELOPMENT 12 190 6.805e-05 0.002363
135 CELL DIVISION 20 460 7.031e-05 0.002423
136 REGULATION OF PHOSPHORUS METABOLIC PROCESS 47 1618 7.102e-05 0.00243
137 CELL CYCLE PHASE TRANSITION 14 255 7.911e-05 0.002687
138 NEGATIVE REGULATION OF MOLECULAR FUNCTION 35 1079 8.033e-05 0.002709
139 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 34 1036 8.151e-05 0.002709
140 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 34 1036 8.151e-05 0.002709
141 TUBE MORPHOGENESIS 16 323 8.427e-05 0.002781
142 MITOTIC CELL CYCLE CHECKPOINT 10 139 9.364e-05 0.003047
143 MORPHOGENESIS OF A BRANCHING STRUCTURE 11 167 9.364e-05 0.003047
144 ANGIOGENESIS 15 293 9.718e-05 0.003135
145 RESPONSE TO ALCOHOL 17 362 9.77e-05 0.003135
146 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 50 1784 9.968e-05 0.003177
147 REGULATION OF ENDOCYTOSIS 12 199 0.0001059 0.003351
148 CELLULAR RESPONSE TO EXTERNAL STIMULUS 14 264 0.0001143 0.003593
149 RESPONSE TO CYTOKINE 26 714 0.0001156 0.003609
150 REGULATION OF RESPONSE TO STRESS 43 1468 0.0001239 0.003845
151 MULTICELLULAR ORGANISM METABOLIC PROCESS 8 93 0.0001371 0.004223
152 DNA INTEGRITY CHECKPOINT 10 146 0.0001408 0.00431
153 REGULATION OF ORGAN FORMATION 5 32 0.0001543 0.004692
154 REGULATION OF CELL DIVISION 14 272 0.0001562 0.004719
155 REGULATION OF OSSIFICATION 11 178 0.0001648 0.004947
156 ARTERY MORPHOGENESIS 6 51 0.0001711 0.005098
157 CELLULAR RESPONSE TO INTERFERON GAMMA 9 122 0.0001728 0.005098
158 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 11 179 0.0001731 0.005098
159 REGULATION OF INTERFERON GAMMA PRODUCTION 8 97 0.0001839 0.005331
160 REGULATION OF CELL CYCLE 31 949 0.0001845 0.005331
161 ENDOCRINE SYSTEM DEVELOPMENT 9 123 0.0001838 0.005331
162 MUSCLE ORGAN DEVELOPMENT 14 277 0.0001887 0.005404
163 CELLULAR RESPONSE TO LIPID 19 457 0.0001893 0.005404
164 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 13 246 0.0002064 0.005855
165 CELL DEATH 32 1001 0.0002135 0.006021
166 ARTERY DEVELOPMENT 7 75 0.0002161 0.006022
167 REGULATION OF IMMUNE EFFECTOR PROCESS 18 424 0.000216 0.006022
168 MITOTIC G2 M TRANSITION CHECKPOINT 4 19 0.0002188 0.006023
169 CARTILAGE DEVELOPMENT INVOLVED IN ENDOCHONDRAL BONE MORPHOGENESIS 4 19 0.0002188 0.006023
170 MITOTIC DNA INTEGRITY CHECKPOINT 8 100 0.0002271 0.006215
171 REGULATION OF EPITHELIAL CELL PROLIFERATION 14 285 0.0002527 0.006876
172 CELLULAR RESPONSE TO STRESS 44 1565 0.0002548 0.006893
173 REGULATION OF INNATE IMMUNE RESPONSE 16 357 0.0002643 0.007107
174 POSITIVE REGULATION OF MAPK CASCADE 19 470 0.0002696 0.007178
175 MIDDLE EAR MORPHOGENESIS 4 20 0.00027 0.007178
176 GLAND DEVELOPMENT 17 395 0.0002748 0.007225
177 T CELL SELECTION 5 36 0.0002739 0.007225
178 MITOTIC NUCLEAR DIVISION 16 361 0.0002991 0.007819
179 RESPONSE TO GROWTH FACTOR 19 475 0.0003076 0.007996
180 MORPHOGENESIS OF AN EPITHELIUM 17 400 0.0003179 0.008171
181 ODONTOGENESIS 8 105 0.0003172 0.008171
182 POSITIVE REGULATION OF RESPONSE TO WOUNDING 10 162 0.0003275 0.008372
183 POSITIVE REGULATION OF HEMOPOIESIS 10 163 0.0003439 0.008697
184 CELLULAR RESPONSE TO BIOTIC STIMULUS 10 163 0.0003439 0.008697
185 POSITIVE REGULATION OF MYELOID CELL DIFFERENTIATION 7 81 0.0003485 0.008746
186 POSITIVE REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 6 58 0.0003496 0.008746
187 CELL FATE COMMITMENT 12 227 0.0003585 0.00892
188 RESPONSE TO ENDOGENOUS STIMULUS 41 1450 0.0003745 0.00922
189 NUCLEAR CHROMOSOME SEGREGATION 12 228 0.000373 0.00922
190 RESPONSE TO WOUNDING 21 563 0.0003827 0.009372
191 NEGATIVE REGULATION OF LOCOMOTION 13 263 0.0003932 0.00948
192 POSITIVE REGULATION OF CELL DEATH 22 605 0.0003946 0.00948
193 RESPIRATORY SYSTEM DEVELOPMENT 11 197 0.0003953 0.00948
194 AORTA MORPHOGENESIS 4 22 0.0003973 0.00948
195 CELLULAR RESPONSE TO ABIOTIC STIMULUS 13 263 0.0003932 0.00948
196 AGING 13 264 0.0004076 0.009654
197 PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 8 109 0.0004087 0.009654
198 NEGATIVE REGULATION OF CELL DIVISION 6 60 0.0004208 0.00984
199 MATERNAL PROCESS INVOLVED IN FEMALE PREGNANCY 6 60 0.0004208 0.00984
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 20 315 2.488e-07 0.0001279
2 EXTRACELLULAR MATRIX STRUCTURAL CONSTITUENT 10 76 4.131e-07 0.0001279
3 SEQUENCE SPECIFIC DNA BINDING 40 1037 3.638e-07 0.0001279
4 PROTEIN COMPLEX BINDING 37 935 5.631e-07 0.0001308
5 COLLAGEN BINDING 9 65 1.017e-06 0.0001574
6 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 16 226 9.702e-07 0.0001574
7 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 19 328 1.971e-06 0.0002615
8 MACROMOLECULAR COMPLEX BINDING 45 1399 8.739e-06 0.001015
9 PLATELET DERIVED GROWTH FACTOR BINDING 4 11 2.064e-05 0.002131
10 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 25 629 3.919e-05 0.003641
11 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 38 1199 6.388e-05 0.005395
12 REGULATORY REGION NUCLEIC ACID BINDING 29 818 7.451e-05 0.005768
13 DOUBLE STRANDED DNA BINDING 27 764 0.0001395 0.009273
14 RECEPTOR BINDING 43 1476 0.0001397 0.009273
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR MATRIX COMPONENT 16 125 2.062e-10 1.204e-07
2 EXTRACELLULAR MATRIX 26 426 8.493e-09 2.48e-06
3 PROTEINACEOUS EXTRACELLULAR MATRIX 23 356 2.225e-08 4.332e-06
4 BASEMENT MEMBRANE 10 93 2.741e-06 0.0004001
5 CELL SURFACE 30 757 6.874e-06 0.0008029
6 EXTRACELLULAR SPACE 44 1376 1.287e-05 0.001253
7 COMPLEX OF COLLAGEN TRIMERS 5 23 2.907e-05 0.001984
8 ENDOPLASMIC RETICULUM LUMEN 13 201 2.658e-05 0.001984
9 BANDED COLLAGEN FIBRIL 4 12 3.057e-05 0.001984
10 MEMBRANE MICRODOMAIN 15 288 8.021e-05 0.004684
11 COLLAGEN TRIMER 8 88 9.278e-05 0.004926

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 ECM_receptor_interaction_hsa04512 10 82 8.496e-07 4.418e-05
2 Phagosome_hsa04145 12 152 7.387e-06 0.0001921
3 Focal_adhesion_hsa04510 12 199 0.0001059 0.001512
4 p53_signaling_pathway_hsa04115 7 68 0.0001163 0.001512
5 Cell_cycle_hsa04110 9 124 0.0001954 0.002032
6 Cell_adhesion_molecules_.CAMs._hsa04514 9 145 0.0006208 0.005113
7 PI3K_Akt_signaling_pathway_hsa04151 15 352 0.0006883 0.005113
8 Cellular_senescence_hsa04218 9 160 0.001249 0.008119
9 Apoptosis_hsa04210 7 138 0.007434 0.04295
10 TNF_signaling_pathway_hsa04668 6 108 0.008426 0.04382
11 Cytokine_cytokine_receptor_interaction_hsa04060 10 270 0.01324 0.06261
12 Ferroptosis_hsa04216 3 40 0.02697 0.1169
13 Wnt_signaling_pathway_hsa04310 6 146 0.03224 0.129
14 Hippo_signaling_pathway_hsa04390 6 154 0.04019 0.1493
15 Regulation_of_actin_cytoskeleton_hsa04810 7 208 0.05396 0.1871
16 HIF_1_signaling_pathway_hsa04066 4 100 0.08022 0.2607
17 Apoptosis_multiple_species_hsa04215 2 33 0.1001 0.3061
18 Adherens_junction_hsa04520 3 72 0.1123 0.3207
19 Rap1_signaling_pathway_hsa04015 6 206 0.1202 0.3207
20 Jak_STAT_signaling_pathway_hsa04630 5 162 0.1248 0.3207
21 Necroptosis_hsa04217 5 164 0.1295 0.3207
22 Lysosome_hsa04142 4 123 0.1406 0.3259
23 Tight_junction_hsa04530 5 170 0.1441 0.3259
24 Hedgehog_signaling_pathway_hsa04340 2 47 0.1774 0.3844
25 Endocytosis_hsa04144 6 244 0.2071 0.4308
26 VEGF_signaling_pathway_hsa04370 2 59 0.2489 0.4978
27 Sphingolipid_signaling_pathway_hsa04071 3 118 0.3007 0.5792
28 MAPK_signaling_pathway_hsa04010 6 295 0.3473 0.6334
29 Apelin_signaling_pathway_hsa04371 3 137 0.385 0.6334
30 Peroxisome_hsa04146 2 83 0.3916 0.6334
31 TGF_beta_signaling_pathway_hsa04350 2 84 0.3973 0.6334
32 cAMP_signaling_pathway_hsa04024 4 198 0.402 0.6334
33 Gap_junction_hsa04540 2 88 0.42 0.6424
34 Neuroactive_ligand_receptor_interaction_hsa04080 5 278 0.4727 0.7023
35 AMPK_signaling_pathway_hsa04152 2 121 0.5878 0.8015
36 Oocyte_meiosis_hsa04114 2 124 0.6011 0.8015
37 FoxO_signaling_pathway_hsa04068 2 132 0.6351 0.8257
38 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.663 0.8409
39 Ras_signaling_pathway_hsa04014 3 232 0.7303 0.9017
40 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.7457 0.9017
41 Calcium_signaling_pathway_hsa04020 2 182 0.7982 0.9224

Quest ID: 22ba2659828092e97ab7707624b215b5