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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-320a SLC2A3 -0.09 0.24303 -0.19 0.05984 miRanda -0.19 0.00421 NA
NumGOOverlapSizeP ValueAdj. P Value
1 RESPONSE TO OXYGEN CONTAINING COMPOUND 22 1381 2.07e-09 9.633e-06
2 SMALL MOLECULE METABOLIC PROCESS 23 1767 3.712e-08 3.455e-05
3 ANION TRANSPORT 13 507 3.299e-08 3.455e-05
4 RESPONSE TO ENDOGENOUS STIMULUS 21 1450 2.831e-08 3.455e-05
5 RESPONSE TO HORMONE 17 893 1.604e-08 3.455e-05
6 ION TRANSPORT 18 1262 4.417e-07 0.0002443
7 ANION TRANSMEMBRANE TRANSPORT 9 251 3.228e-07 0.0002443
8 RESPONSE TO DRUG 11 431 4.39e-07 0.0002443
9 RESPONSE TO REACTIVE OXYGEN SPECIES 8 191 4.725e-07 0.0002443
10 RESPONSE TO OXIDATIVE STRESS 10 352 5.831e-07 0.0002713
11 ORGANIC ACID METABOLIC PROCESS 15 953 1.443e-06 0.0006105
12 RESPONSE TO PEPTIDE 10 404 2.024e-06 0.0007243
13 MONOCARBOXYLIC ACID METABOLIC PROCESS 11 503 1.988e-06 0.0007243
14 CELLULAR RESPONSE TO HORMONE STIMULUS 11 552 4.847e-06 0.001611
15 PROTEIN LIPID COMPLEX SUBUNIT ORGANIZATION 4 36 8.806e-06 0.002732
16 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 10 482 9.61e-06 0.002795
17 ORGANIC ANION TRANSPORT 9 387 1.128e-05 0.003088
18 FATTY ACID METABOLIC PROCESS 8 296 1.223e-05 0.003161
19 REGULATION OF CHOLESTEROL STORAGE 3 13 1.3e-05 0.003183
20 ANION HOMEOSTASIS 4 41 1.493e-05 0.003309
21 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 14 1008 1.425e-05 0.003309
22 POSITIVE REGULATION OF CHOLESTEROL EFFLUX 3 14 1.65e-05 0.003489
23 CELLULAR LIPID CATABOLIC PROCESS 6 151 1.881e-05 0.003806
24 HOMEOSTATIC PROCESS 16 1337 2.027e-05 0.00393
25 REGULATION OF PLASMA LIPOPROTEIN PARTICLE LEVELS 4 45 2.173e-05 0.004044
26 RESPONSE TO ORGANIC CYCLIC COMPOUND 13 917 2.436e-05 0.004351
27 TOR SIGNALING 3 16 2.525e-05 0.004351
28 POSITIVE REGULATION OF STEROL TRANSPORT 3 17 3.058e-05 0.004904
29 RESPONSE TO EXTRACELLULAR STIMULUS 9 441 3.162e-05 0.004904
30 POSITIVE REGULATION OF CHOLESTEROL TRANSPORT 3 17 3.058e-05 0.004904
31 TERPENOID METABOLIC PROCESS 5 106 4.29e-05 0.006439
32 ORGANIC ACID TRANSPORT 7 261 4.651e-05 0.006763
33 REGULATION OF CHOLESTEROL EFFLUX 3 20 5.086e-05 0.007011
34 LIPID HOMEOSTASIS 5 110 5.123e-05 0.007011
35 RESPONSE TO NITROGEN COMPOUND 12 859 5.999e-05 0.007545
36 PROTEIN LIPID COMPLEX ASSEMBLY 3 21 5.919e-05 0.007545
37 RESPONSE TO INORGANIC SUBSTANCE 9 479 5.998e-05 0.007545
38 STEROL HOMEOSTASIS 4 59 6.386e-05 0.007619
39 CHOLESTEROL HOMEOSTASIS 4 59 6.386e-05 0.007619
40 LIPID METABOLIC PROCESS 14 1158 6.551e-05 0.007621
41 RESPONSE TO ABIOTIC STIMULUS 13 1024 7.591e-05 0.008615
42 RESPONSE TO STEROID HORMONE 9 497 7.956e-05 0.008814
43 RESPONSE TO LIPID 12 888 8.24e-05 0.008916
44 NITROGEN COMPOUND TRANSPORT 9 507 9.259e-05 0.009791
45 REGULATION OF INFLAMMATORY RESPONSE 7 294 9.82e-05 0.009933
46 ISOPRENOID METABOLIC PROCESS 5 126 9.771e-05 0.009933
NumGOOverlapSizeP ValueAdj. P Value
1 ANION TRANSMEMBRANE TRANSPORTER ACTIVITY 10 293 1.075e-07 9.99e-05
2 ACTIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 9 356 5.774e-06 0.002682
3 TRANSMEMBRANE TRANSPORTER ACTIVITY 14 997 1.259e-05 0.0039
4 ACTIVE ION TRANSMEMBRANE TRANSPORTER ACTIVITY 6 171 3.792e-05 0.008806
5 TRANSPORTER ACTIVITY 15 1276 4.743e-05 0.008812
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 mTOR_signaling_pathway_hsa04150 5 151 0.0002281 0.01186
2 ABC_transporters_hsa02010 3 45 0.000593 0.01542
3 AMPK_signaling_pathway_hsa04152 4 121 0.001005 0.01743
4 Adherens_junction_hsa04520 3 72 0.002323 0.0302
5 PI3K_Akt_signaling_pathway_hsa04151 4 352 0.0398 0.3564
6 Gap_junction_hsa04540 2 88 0.04112 0.3564
7 HIF_1_signaling_pathway_hsa04066 2 100 0.05172 0.3842
8 Sphingolipid_signaling_pathway_hsa04071 2 118 0.0692 0.4141
9 Lysosome_hsa04142 2 123 0.07436 0.4141
10 Autophagy_animal_hsa04140 2 128 0.07963 0.4141
11 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.09953 0.4705
12 Cellular_senescence_hsa04218 2 160 0.1159 0.4751
13 Necroptosis_hsa04217 2 164 0.1206 0.4751
14 Tight_junction_hsa04530 2 170 0.1279 0.4751

Quest ID: 22e0952768aaec2f9a0cb48556405a68