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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-454-3p ACSL1 1.4 0.00366 -0.26 0.66804 MirTarget -0.21 0.00407 NA
2 hsa-miR-454-3p ACSL4 1.4 0.00366 -0.89 0.13062 MirTarget; miRNATAP -0.14 0.04315 NA
3 hsa-miR-454-3p ACVR1 1.4 0.00366 -0.76 0.04389 MirTarget; miRNATAP -0.12 0.00599 NA
4 hsa-miR-454-3p AKAP11 1.4 0.00366 -0.61 0.12508 miRNATAP -0.12 0.00898 NA
5 hsa-miR-454-3p AMPD3 1.4 0.00366 1.34 0.01947 MirTarget; miRNATAP -0.28 3.0E-5 NA
6 hsa-miR-454-3p ANKRD12 1.4 0.00366 -0.49 0.18892 MirTarget; miRNATAP -0.11 0.01667 NA
7 hsa-miR-106a-5p APCDD1 3.99 0 -2.17 0.00459 MirTarget -0.15 0.00407 NA
8 hsa-miR-130b-3p APCDD1 3.92 0 -2.17 0.00459 MirTarget -0.18 0.0162 NA
9 hsa-miR-20b-5p APCDD1 4.57 5.0E-5 -2.17 0.00459 MirTarget -0.1 0.00797 NA
10 hsa-miR-330-5p APCDD1 2.25 0.00028 -2.17 0.00459 miRanda -0.14 0.04065 NA
11 hsa-miR-93-5p APCDD1 2.66 0 -2.17 0.00459 MirTarget -0.23 0.01143 NA
12 hsa-miR-454-3p AR 1.4 0.00366 -4.57 0.00169 mirMAP; miRNATAP -0.47 0.00625 NA
13 hsa-miR-454-3p ARAP2 1.4 0.00366 1.71 0.00222 MirTarget -0.2 0.00207 NA
14 hsa-miR-454-3p ARHGAP21 1.4 0.00366 -0.14 0.76187 MirTarget; miRNATAP -0.14 0.01042 NA
15 hsa-miR-454-3p ARHGEF12 1.4 0.00366 -0.4 0.28538 MirTarget; miRNATAP -0.16 0.0003 NA
16 hsa-miR-454-3p ASPA 1.4 0.00366 -5.53 0 mirMAP -0.32 0.02559 NA
17 hsa-miR-454-3p ASXL2 1.4 0.00366 0.95 0.22717 MirTarget; miRNATAP -0.2 0.03105 NA
18 hsa-miR-454-3p ATP6V1B2 1.4 0.00366 0.23 0.47152 MirTarget; miRNATAP -0.1 0.00585 NA
19 hsa-miR-454-3p ATXN1 1.4 0.00366 -1.43 0.00387 miRNATAP -0.17 0.00303 NA
20 hsa-miR-454-3p BBX 1.4 0.00366 -0.18 0.63612 MirTarget; miRNATAP -0.1 0.02182 NA
21 hsa-miR-454-3p BCL9L 1.4 0.00366 -0.12 0.78985 mirMAP -0.14 0.00577 NA
22 hsa-miR-454-3p BHLHE40 1.4 0.00366 0.96 0.11887 miRNAWalker2 validate -0.24 0.00086 NA
23 hsa-miR-454-3p BRWD3 1.4 0.00366 2.22 0.00115 MirTarget; miRNATAP -0.2 0.01287 NA
24 hsa-miR-454-3p BTBD10 1.4 0.00366 0.43 0.25557 MirTarget -0.18 3.0E-5 NA
25 hsa-miR-454-3p BTG1 1.4 0.00366 -0.9 0.02841 miRNATAP -0.11 0.02771 NA
26 hsa-miR-454-3p C15orf52 1.4 0.00366 -1.2 0.18499 mirMAP -0.36 0.00077 NA
27 hsa-miR-454-3p C1S 1.4 0.00366 -2.07 0.01886 MirTarget -0.25 0.01612 NA
28 hsa-miR-454-3p CD109 1.4 0.00366 -0.13 0.90668 mirMAP -0.3 0.02391 NA
29 hsa-miR-454-3p CD69 1.4 0.00366 -0.72 0.42333 miRNATAP -0.25 0.01834 NA
30 hsa-miR-454-3p CDH11 1.4 0.00366 -2.72 0.00843 mirMAP -0.48 7.0E-5 NA
31 hsa-miR-454-3p CHD9 1.4 0.00366 -0.3 0.4758 miRNATAP -0.17 0.00054 NA
32 hsa-miR-454-3p CLIP1 1.4 0.00366 0.26 0.56626 MirTarget; miRNATAP -0.21 7.0E-5 NA
33 hsa-miR-454-3p CPEB2 1.4 0.00366 -0.48 0.40022 miRNATAP -0.16 0.01428 NA
34 hsa-miR-454-3p CPEB4 1.4 0.00366 -0.65 0.23946 miRNATAP -0.16 0.01341 NA
35 hsa-miR-454-3p CRISPLD1 1.4 0.00366 -3 0.03284 MirTarget -0.4 0.01665 NA
36 hsa-miR-454-3p CSF1 1.4 0.00366 -1.1 0.12732 MirTarget; miRNATAP -0.2 0.02018 NA
37 hsa-miR-454-3p CTSK 1.4 0.00366 -3.32 1.0E-5 MirTarget -0.47 0 NA
38 hsa-miR-454-3p CYLD 1.4 0.00366 -0.05 0.90145 miRNATAP -0.12 0.0045 25824771 MiR 454 prompts cell proliferation of human colorectal cancer cells by repressing CYLD expression; Bioinformatics analysis further revealed cylindromatosis CYLD a putative tumor suppressor as a potential target of miR-454; Data from luciferase reporter assays showed that miR-454 directly binds to the 3'-untranslated region 3'-UTR of CYLD mRNA and repressed expression at both transcriptional and translational levels; In sum our data provide compelling evidence that miR-454 functions as an onco-miRNA playing a crucial role in the promoting cell proliferation in CRC and its oncogenic effect is mediated chiefly through direct suppression of CYLD expression
39 hsa-miR-454-3p CYP4F3 1.4 0.00366 5.4 0.001 mirMAP -0.39 0.04343 NA
40 hsa-miR-454-3p DAAM1 1.4 0.00366 0.28 0.67526 MirTarget; miRNATAP -0.24 0.00186 NA
41 hsa-miR-454-3p DLC1 1.4 0.00366 -3.66 0 miRNATAP -0.3 0.00062 NA
42 hsa-miR-454-3p DNM3 1.4 0.00366 -2.57 0.00056 mirMAP -0.27 0.00193 NA
43 hsa-miR-454-3p DYRK2 1.4 0.00366 0.06 0.87911 mirMAP -0.11 0.02274 NA
44 hsa-miR-454-3p EEA1 1.4 0.00366 -0.24 0.59857 mirMAP -0.23 2.0E-5 NA
45 hsa-miR-454-3p ELK3 1.4 0.00366 -0.79 0.2934 MirTarget; miRNATAP -0.42 0 NA
46 hsa-miR-454-3p ENAH 1.4 0.00366 -0.27 0.60264 miRNATAP -0.13 0.03879 NA
47 hsa-miR-454-3p ENDOD1 1.4 0.00366 -1.15 0.01857 MirTarget -0.23 4.0E-5 NA
48 hsa-miR-454-3p ESR1 1.4 0.00366 -4.87 9.0E-5 miRNATAP -0.52 0.00045 NA
49 hsa-miR-454-3p EVI5 1.4 0.00366 -0.95 0.00393 mirMAP -0.1 0.00889 NA
50 hsa-miR-454-3p FAM155A 1.4 0.00366 -3.09 0.00443 MirTarget -0.36 0.00573 NA
51 hsa-miR-454-3p FAM179B 1.4 0.00366 -0.56 0.15244 miRNATAP -0.12 0.0124 NA
52 hsa-miR-454-3p FAM46B 1.4 0.00366 0.42 0.68311 MirTarget; miRNATAP -0.29 0.01569 NA
53 hsa-miR-454-3p FIBIN 1.4 0.00366 -3.85 0.00528 MirTarget -0.66 4.0E-5 NA
54 hsa-miR-454-3p FLNC 1.4 0.00366 -5.77 0 miRNAWalker2 validate -0.44 0.00361 NA
55 hsa-miR-454-3p FMN1 1.4 0.00366 1.87 0.076 mirMAP -0.29 0.02163 NA
56 hsa-miR-454-3p FOSL1 1.4 0.00366 2.1 0.0498 MirTarget -0.34 0.00737 NA
57 hsa-miR-454-3p FRMD6 1.4 0.00366 -1.61 0.08207 MirTarget -0.41 0.00018 NA
58 hsa-miR-454-3p FRZB 1.4 0.00366 -4.07 5.0E-5 MirTarget -0.25 0.0365 NA
59 hsa-miR-454-3p FZD6 1.4 0.00366 1.58 0.00919 MirTarget -0.15 0.04098 NA
60 hsa-miR-454-3p G0S2 1.4 0.00366 0.4 0.71817 MirTarget -0.33 0.01043 NA
61 hsa-miR-454-3p GADD45A 1.4 0.00366 -0.57 0.35686 MirTarget; miRNATAP -0.31 2.0E-5 NA
62 hsa-miR-454-3p GBP4 1.4 0.00366 0.55 0.60015 mirMAP -0.28 0.02105 NA
63 hsa-miR-454-3p GCLM 1.4 0.00366 1.75 0.00401 mirMAP -0.17 0.01881 NA
64 hsa-miR-454-3p GFOD1 1.4 0.00366 0.92 0.20897 mirMAP -0.19 0.02487 NA
65 hsa-miR-454-3p GJA1 1.4 0.00366 -1.39 0.17815 MirTarget; miRNATAP -0.29 0.01745 NA
66 hsa-miR-454-3p GPR157 1.4 0.00366 2.04 0.0467 mirMAP -0.28 0.02172 NA
67 hsa-miR-454-3p GPRC5A 1.4 0.00366 1.52 0.16803 mirMAP -0.28 0.03169 NA
68 hsa-miR-454-3p HECW2 1.4 0.00366 -0.59 0.4122 MirTarget -0.3 0.00041 NA
69 hsa-miR-454-3p HEG1 1.4 0.00366 -1.11 0.15703 miRNATAP -0.38 3.0E-5 NA
70 hsa-miR-454-3p HERC3 1.4 0.00366 -0.31 0.56561 MirTarget -0.17 0.00587 NA
71 hsa-miR-454-3p HES2 1.4 0.00366 6.53 1.0E-5 mirMAP -0.46 0.00885 NA
72 hsa-miR-454-3p HIPK3 1.4 0.00366 -0.3 0.74415 MirTarget -0.27 0.01549 NA
73 hsa-miR-454-3p HIVEP2 1.4 0.00366 0.14 0.72176 miRNATAP -0.14 0.00237 NA
74 hsa-miR-454-3p HRH1 1.4 0.00366 -0.68 0.33264 mirMAP -0.25 0.00253 NA
75 hsa-miR-454-3p IGF1 1.4 0.00366 -4.48 0.00149 MirTarget -0.4 0.01817 NA
76 hsa-miR-454-3p IL1RAP 1.4 0.00366 1.81 0.02672 MirTarget -0.21 0.02802 NA
77 hsa-miR-454-3p ITGA2 1.4 0.00366 2.49 0.01604 mirMAP -0.27 0.02766 NA
78 hsa-miR-454-3p ITGA8 1.4 0.00366 -4.42 0.00157 mirMAP -0.58 0.00047 NA
79 hsa-miR-454-3p ITPR1 1.4 0.00366 -3.7 0 MirTarget; miRNATAP -0.37 0 NA
80 hsa-miR-454-3p JAM2 1.4 0.00366 -5.56 0 miRNATAP -0.38 0.00044 NA
81 hsa-miR-454-3p KCTD10 1.4 0.00366 -1.32 0 MirTarget -0.13 4.0E-5 NA
82 hsa-miR-454-3p KIAA1462 1.4 0.00366 -4.22 0 MirTarget -0.23 0.00673 NA
83 hsa-miR-454-3p KLF3 1.4 0.00366 0.06 0.86707 miRNATAP -0.13 0.00241 NA
84 hsa-miR-454-3p KLF7 1.4 0.00366 0.14 0.86538 MirTarget; miRNATAP -0.23 0.02034 NA
85 hsa-miR-454-3p KLHL20 1.4 0.00366 -0.29 0.43362 MirTarget; miRNATAP -0.16 0.00028 NA
86 hsa-miR-454-3p LDLR 1.4 0.00366 0.07 0.90897 miRNATAP -0.18 0.01661 NA
87 hsa-miR-454-3p LIPA 1.4 0.00366 -0.18 0.71748 MirTarget -0.12 0.04269 NA
88 hsa-miR-454-3p LNPEP 1.4 0.00366 1.08 0.04117 MirTarget; miRNATAP -0.13 0.03362 NA
89 hsa-miR-454-3p LPP 1.4 0.00366 -1.15 0.02938 mirMAP -0.19 0.00183 NA
90 hsa-miR-454-3p LRCH2 1.4 0.00366 -5.17 0 MirTarget; miRNATAP -0.44 0.00017 NA
91 hsa-miR-454-3p MAFB 1.4 0.00366 0.68 0.42819 miRNATAP -0.26 0.00981 NA
92 hsa-miR-454-3p MAP4 1.4 0.00366 -0.73 0.032 MirTarget -0.1 0.01022 NA
93 hsa-miR-454-3p MAPK10 1.4 0.00366 -4.03 0.00046 miRNATAP -0.57 2.0E-5 NA
94 hsa-miR-454-3p MBNL3 1.4 0.00366 1.26 0.12966 MirTarget; mirMAP; miRNATAP -0.21 0.02942 NA
95 hsa-miR-454-3p MCC 1.4 0.00366 -0.68 0.46777 MirTarget -0.32 0.00382 NA
96 hsa-miR-454-3p MDFIC 1.4 0.00366 -1.36 0.0449 MirTarget; miRNATAP -0.2 0.01345 NA
97 hsa-miR-454-3p MED12 1.4 0.00366 0.15 0.67052 miRNAWalker2 validate -0.12 0.00404 NA
98 hsa-miR-454-3p MEOX2 1.4 0.00366 -6.19 0 MirTarget; miRNATAP -0.34 0.01532 NA
99 hsa-miR-454-3p MID1IP1 1.4 0.00366 0.66 0.10505 miRNATAP -0.12 0.01561 NA
100 hsa-miR-454-3p MMP16 1.4 0.00366 -2.72 0.00811 mirMAP -0.32 0.00815 NA
101 hsa-miR-454-3p MPPED2 1.4 0.00366 -2.45 0.15823 MirTarget -0.6 0.00333 NA
102 hsa-miR-454-3p MUC20 1.4 0.00366 1.73 0.20488 mirMAP -0.34 0.03626 NA
103 hsa-miR-454-3p NAP1L3 1.4 0.00366 -5.22 0 MirTarget -0.5 1.0E-5 NA
104 hsa-miR-454-3p NAV1 1.4 0.00366 0.37 0.59295 miRNATAP -0.31 0.00012 NA
105 hsa-miR-454-3p NFIA 1.4 0.00366 -0.82 0.18121 miRNATAP -0.22 0.00242 NA
106 hsa-miR-454-3p NFIC 1.4 0.00366 -0.58 0.41726 miRNATAP -0.17 0.04248 NA
107 hsa-miR-454-3p NHLH2 1.4 0.00366 2.73 0.13264 MirTarget; miRNATAP -0.55 0.01024 NA
108 hsa-miR-454-3p NOX4 1.4 0.00366 -2.45 0.00259 MirTarget -0.25 0.00813 NA
109 hsa-miR-454-3p NPAT 1.4 0.00366 0.09 0.81886 MirTarget; miRNATAP -0.12 0.00874 NA
110 hsa-miR-454-3p PCDHB4 1.4 0.00366 -4.44 0 MirTarget -0.41 0.00019 NA
111 hsa-miR-454-3p PDCD1LG2 1.4 0.00366 -0.81 0.39863 MirTarget -0.35 0.00234 NA
112 hsa-miR-454-3p PDGFRA 1.4 0.00366 -4.32 1.0E-5 MirTarget; miRNATAP -0.46 8.0E-5 NA
113 hsa-miR-454-3p PGM2L1 1.4 0.00366 -1.68 0.03208 MirTarget; miRNATAP -0.2 0.02728 NA
114 hsa-miR-454-3p PGR 1.4 0.00366 -7.62 0 mirMAP -0.66 0.00018 NA
115 hsa-miR-454-3p PLCB1 1.4 0.00366 -1.81 0.07239 miRNATAP -0.3 0.01148 NA
116 hsa-miR-454-3p PMEPA1 1.4 0.00366 -0.44 0.56222 MirTarget; miRNATAP -0.22 0.0153 NA
117 hsa-miR-454-3p POLR2A 1.4 0.00366 0.02 0.96289 miRNAWalker2 validate -0.12 0.00447 NA
118 hsa-miR-454-3p PPP1R12B 1.4 0.00366 -4.65 0 mirMAP -0.37 1.0E-5 NA
119 hsa-miR-454-3p PRKG1 1.4 0.00366 -4.14 0.00035 miRNATAP -0.54 9.0E-5 NA
120 hsa-miR-454-3p PSD 1.4 0.00366 -5.74 0 miRNATAP -0.27 0.00711 NA
121 hsa-miR-454-3p PTGFRN 1.4 0.00366 0.01 0.98805 miRNATAP -0.13 0.01288 NA
122 hsa-miR-454-3p PXK 1.4 0.00366 -1.19 0.05304 MirTarget -0.17 0.02128 NA
123 hsa-miR-454-3p RALGPS2 1.4 0.00366 1.31 0.01845 MirTarget -0.2 0.00201 NA
124 hsa-miR-454-3p RAP2C 1.4 0.00366 -0.96 0.01088 miRNAWalker2 validate; MirTarget; miRNATAP -0.18 3.0E-5 NA
125 hsa-miR-454-3p RAPGEF4 1.4 0.00366 -2.71 0.0001 MirTarget; miRNATAP -0.18 0.03366 NA
126 hsa-miR-454-3p RARB 1.4 0.00366 -1.23 0.24963 miRNATAP -0.51 5.0E-5 NA
127 hsa-miR-454-3p RASL12 1.4 0.00366 -5.24 0 MirTarget -0.31 0.00122 NA
128 hsa-miR-454-3p RASSF6 1.4 0.00366 4.23 0.00014 mirMAP -0.27 0.03868 NA
129 hsa-miR-454-3p RC3H2 1.4 0.00366 0.73 0.09436 mirMAP -0.1 0.0489 NA
130 hsa-miR-454-3p RNF11 1.4 0.00366 -0.85 0.01247 miRNATAP -0.14 0.00051 NA
131 hsa-miR-454-3p ROBO1 1.4 0.00366 0.25 0.74813 miRNATAP -0.25 0.00697 NA
132 hsa-miR-454-3p ROBO2 1.4 0.00366 -1.5 0.3479 miRNATAP -0.5 0.00798 NA
133 hsa-miR-454-3p RUNX1T1 1.4 0.00366 -4.61 4.0E-5 miRNATAP -0.54 5.0E-5 NA
134 hsa-miR-454-3p RUNX2 1.4 0.00366 0.93 0.19285 miRNATAP -0.3 0.00038 NA
135 hsa-miR-454-3p S1PR1 1.4 0.00366 -4.01 0 MirTarget; miRNATAP -0.28 0.00027 NA
136 hsa-miR-454-3p SAMHD1 1.4 0.00366 1.22 0.08415 mirMAP -0.17 0.04153 NA
137 hsa-miR-454-3p SASH1 1.4 0.00366 -1.01 0.06247 MirTarget; miRNATAP -0.15 0.01615 NA
138 hsa-miR-454-3p SBF2 1.4 0.00366 -0.78 0.06145 MirTarget -0.14 0.00328 NA
139 hsa-miR-454-3p SCN3A 1.4 0.00366 -3.02 0.0067 MirTarget -0.3 0.0227 NA
140 hsa-miR-454-3p SESN3 1.4 0.00366 -0.38 0.69604 mirMAP -0.3 0.00906 NA
141 hsa-miR-454-3p SETD7 1.4 0.00366 -1.43 0.00158 miRNATAP -0.11 0.0386 NA
142 hsa-miR-454-3p SH3D19 1.4 0.00366 -1.17 0.00804 MirTarget; miRNATAP -0.22 2.0E-5 NA
143 hsa-miR-454-3p SHROOM4 1.4 0.00366 -2.05 0.01488 mirMAP -0.29 0.00335 NA
144 hsa-miR-454-3p SIK3 1.4 0.00366 -0.94 0.00631 miRNAWalker2 validate -0.16 0.0001 NA
145 hsa-miR-454-3p SLC24A3 1.4 0.00366 -4.25 0.00045 MirTarget; miRNATAP -0.46 0.00125 NA
146 hsa-miR-454-3p SLC35D1 1.4 0.00366 0.16 0.71932 MirTarget -0.17 0.00137 NA
147 hsa-miR-454-3p SLC8A1 1.4 0.00366 -4.53 0 MirTarget -0.35 0.00027 NA
148 hsa-miR-454-3p SLIT3 1.4 0.00366 -4.87 1.0E-5 mirMAP -0.38 0.00345 NA
149 hsa-miR-454-3p SLMAP 1.4 0.00366 -1.88 0 MirTarget -0.19 1.0E-5 NA
150 hsa-miR-454-3p SMOC2 1.4 0.00366 -6.42 0 miRNATAP -0.33 0.00948 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 42 1805 3.215e-08 0.0001496
2 SKELETAL SYSTEM DEVELOPMENT 18 455 3.434e-07 0.0005227
3 EMBRYONIC ORGAN MORPHOGENESIS 14 279 4.494e-07 0.0005227
4 ORGAN MORPHOGENESIS 25 841 3.94e-07 0.0005227
5 DEVELOPMENTAL GROWTH 15 333 6.814e-07 0.0006335
6 NEGATIVE REGULATION OF CELL PROLIFERATION 21 643 8.169e-07 0.0006335
7 TUBE DEVELOPMENT 19 552 1.305e-06 0.0008675
8 POSITIVE REGULATION OF MOLECULAR FUNCTION 38 1791 1.673e-06 0.0009369
9 GROWTH 16 410 1.893e-06 0.0009369
10 TISSUE DEVELOPMENT 34 1518 2.014e-06 0.0009369
11 CENTRAL NERVOUS SYSTEM DEVELOPMENT 24 872 2.644e-06 0.001118
12 EMBRYO DEVELOPMENT 24 894 4.048e-06 0.00157
13 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 18 554 5.601e-06 0.001861
14 POSITIVE REGULATION OF GENE EXPRESSION 36 1733 5.367e-06 0.001861
15 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 35 1672 6.292e-06 0.001894
16 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 8 104 6.514e-06 0.001894
17 CARDIAC MUSCLE TISSUE DEVELOPMENT 9 140 7.506e-06 0.002003
18 EMBRYONIC ORGAN DEVELOPMENT 15 406 7.75e-06 0.002003
19 EPITHELIUM DEVELOPMENT 24 945 1.027e-05 0.002186
20 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 25 1008 9.921e-06 0.002186
21 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 25 1004 9.269e-06 0.002186
22 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 10 184 1.033e-05 0.002186
23 MUSCLE TISSUE DEVELOPMENT 12 275 1.263e-05 0.002257
24 TISSUE MORPHOGENESIS 17 533 1.31e-05 0.002257
25 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 25 1021 1.234e-05 0.002257
26 TUBE MORPHOGENESIS 13 323 1.297e-05 0.002257
27 POSITIVE REGULATION OF CELL DIFFERENTIATION 22 823 1.127e-05 0.002257
28 POSITIVE REGULATION OF CATALYTIC ACTIVITY 32 1518 1.462e-05 0.002427
29 EMBRYONIC MORPHOGENESIS 17 539 1.512e-05 0.002427
30 BONE DEVELOPMENT 9 156 1.795e-05 0.002784
31 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 8 122 2.108e-05 0.003089
32 NEUROGENESIS 30 1402 2.124e-05 0.003089
33 REGULATION OF CELL DIFFERENTIATION 31 1492 2.684e-05 0.003785
34 CELL DEVELOPMENT 30 1426 2.923e-05 0.004001
35 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 29 1360 3.164e-05 0.004206
36 CARDIOCYTE DIFFERENTIATION 7 96 3.532e-05 0.004565
37 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 24 1036 4.544e-05 0.005286
38 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 24 1036 4.544e-05 0.005286
39 ORGAN GROWTH 6 68 4.427e-05 0.005286
40 HEAD DEVELOPMENT 19 709 4.478e-05 0.005286
41 NEGATIVE REGULATION OF CELL COMMUNICATION 26 1192 5.857e-05 0.006647
42 CELL JUNCTION ORGANIZATION 9 185 6.841e-05 0.007398
43 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 11 278 7.086e-05 0.007398
44 CARDIAC MUSCLE CELL DIFFERENTIATION 6 74 7.149e-05 0.007398
45 EMBRYONIC CRANIAL SKELETON MORPHOGENESIS 5 46 7.155e-05 0.007398
46 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 25 1142 7.772e-05 0.007862
47 CARTILAGE DEVELOPMENT 8 147 7.981e-05 0.007902
48 RESPONSE TO ENDOGENOUS STIMULUS 29 1450 9.918e-05 0.009418
49 CONNECTIVE TISSUE DEVELOPMENT 9 194 9.847e-05 0.009418
50 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 8 153 0.0001056 0.009825
NumGOOverlapSizeP ValueAdj. P Value
1 REGULATORY REGION NUCLEIC ACID BINDING 23 818 3.054e-06 0.0009456
2 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 14 328 3.044e-06 0.0009456
3 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 12 226 1.696e-06 0.0009456
4 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 13 315 9.932e-06 0.001845
5 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 19 629 8.615e-06 0.001845
6 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 27 1199 2.393e-05 0.003706
7 TRANSCRIPTION FACTOR BINDING 16 524 4.01e-05 0.005321
8 CORE PROMOTER PROXIMAL REGION DNA BINDING 13 371 5.472e-05 0.006354
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 12 295 2.531e-05 0.0009672
2 FoxO_signaling_pathway_hsa04068 8 132 3.72e-05 0.0009672
3 Gap_junction_hsa04540 6 88 0.0001875 0.00325
4 Endocytosis_hsa04144 9 244 0.0005392 0.005762
5 Focal_adhesion_hsa04510 8 199 0.0006256 0.005762
6 Hippo_signaling_pathway_hsa04390 7 154 0.0006649 0.005762
7 Oocyte_meiosis_hsa04114 6 124 0.001168 0.008677
8 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.002533 0.01546
9 Wnt_signaling_pathway_hsa04310 6 146 0.002675 0.01546
10 mTOR_signaling_pathway_hsa04150 6 151 0.003161 0.01644
11 Regulation_of_actin_cytoskeleton_hsa04810 7 208 0.003699 0.01702
12 p53_signaling_pathway_hsa04115 4 68 0.003928 0.01702
13 Ferroptosis_hsa04216 3 40 0.006347 0.02539
14 TGF_beta_signaling_pathway_hsa04350 4 84 0.008284 0.03077
15 Phospholipase_D_signaling_pathway_hsa04072 5 146 0.01264 0.04383
16 Cellular_senescence_hsa04218 5 160 0.01811 0.05887
17 cGMP_PKG_signaling_pathway_hsa04022 5 163 0.01946 0.05952
18 Calcium_signaling_pathway_hsa04020 5 182 0.02952 0.08528
19 Apoptosis_hsa04210 4 138 0.04211 0.1079
20 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 4 139 0.04305 0.1079
21 Cytokine_cytokine_receptor_interaction_hsa04060 6 270 0.04358 0.1079
22 Rap1_signaling_pathway_hsa04015 5 206 0.04624 0.1093
23 Phagosome_hsa04145 4 152 0.05634 0.1274
24 Ras_signaling_pathway_hsa04014 5 232 0.06962 0.1508
25 Sphingolipid_signaling_pathway_hsa04071 3 118 0.1012 0.2106
26 Lysosome_hsa04142 3 123 0.1111 0.2221
27 PI3K_Akt_signaling_pathway_hsa04151 6 352 0.1175 0.2263
28 Apelin_signaling_pathway_hsa04371 3 137 0.1403 0.2606
29 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.1581 0.2835
30 ECM_receptor_interaction_hsa04512 2 82 0.1817 0.3104
31 Peroxisome_hsa04146 2 83 0.1851 0.3104
32 ErbB_signaling_pathway_hsa04012 2 85 0.1919 0.3118
33 Tight_junction_hsa04530 3 170 0.2174 0.3425
34 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.2404 0.3676
35 TNF_signaling_pathway_hsa04668 2 108 0.2719 0.3927
36 Cell_cycle_hsa04110 2 124 0.3276 0.4605
37 Autophagy_animal_hsa04140 2 128 0.3414 0.4672
38 Jak_STAT_signaling_pathway_hsa04630 2 162 0.454 0.5848
39 Necroptosis_hsa04217 2 164 0.4603 0.5848
40 cAMP_signaling_pathway_hsa04024 2 198 0.5604 0.6777
41 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.7414 0.8381

Quest ID: 233210e0c82ad283324fcdf4af7bf7c6