Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-183-5p ABCA1 2.08 0 0.61 0.0002 miRNATAP -0.17 0 26935154 MiR 183 functions as an oncogene by targeting ABCA1 in colon cancer; We found that miR-183 targets the 3'UTR of ABCA1 mRNA; Subsequent experiments confirmed that miR-183 degraded ABCA1 mRNA in the colon cancer cells; Thus we conclude that miR-183 promotes proliferation and inhibits apoptosis by degrading ABCA1 in colon cancer
2 hsa-miR-200b-3p ABCA1 2.06 0 0.61 0.0002 TargetScan -0.16 0 NA
3 hsa-miR-192-5p ABCA8 2.09 0 -2.99 0 miRNAWalker2 validate -0.49 0 NA
4 hsa-miR-146b-5p ABCC5 2.23 0 -0.7 0 PITA -0.12 0.00125 NA
5 hsa-miR-200b-3p ABI2 2.06 0 0.18 0.14787 TargetScan -0.17 0 NA
6 hsa-miR-21-5p ACAT1 2.22 0 -0.96 0 miRNAWalker2 validate -0.32 0 NA
7 hsa-miR-146b-3p ACSL1 2.09 0 -0.58 4.0E-5 PITA -0.12 0.00181 NA
8 hsa-miR-192-5p ACSL1 2.09 0 -0.58 4.0E-5 miRNAWalker2 validate -0.11 0 NA
9 hsa-miR-196a-5p ACSL6 5.06 0 -1.59 0 miRNATAP -0.12 0.00101 NA
10 hsa-miR-196b-5p ACSL6 4.52 0 -1.59 0 miRNATAP -0.15 4.0E-5 NA
11 hsa-miR-935 ACSL6 2.32 0 -1.59 0 PITA -0.26 0 NA
12 hsa-miR-200b-3p ACTR1A 2.06 0 -0.4 0 TargetScan -0.11 0 NA
13 hsa-miR-200b-3p ADAMTS3 2.06 0 0.38 0.04723 TargetScan -0.18 0 NA
14 hsa-miR-146b-5p ADARB1 2.23 0 -0.34 0.06631 miRNATAP -0.24 0 NA
15 hsa-miR-200b-3p ADCY2 2.06 0 -1.53 4.0E-5 TargetScan -0.62 0 NA
16 hsa-miR-200b-3p ADCY9 2.06 0 -0.36 0.01911 TargetScan -0.21 0 NA
17 hsa-miR-146b-5p AFAP1L2 2.23 0 -0.28 0.15434 miRNATAP -0.2 5.0E-5 NA
18 hsa-miR-200b-3p AFF1 2.06 0 -0.38 0.00053 TargetScan -0.14 0 NA
19 hsa-miR-200b-3p AFF3 2.06 0 -2.37 0 TargetScan -0.56 0 NA
20 hsa-miR-18a-5p AFF4 2.05 0 -0.27 0.01565 miRNAWalker2 validate -0.15 0 NA
21 hsa-miR-200b-3p AHNAK 2.06 0 -1.21 0 TargetScan -0.32 0 NA
22 hsa-miR-146b-3p AJAP1 2.09 0 -0.56 0.04832 miRNATAP -0.2 0.00594 NA
23 hsa-miR-200a-3p AK4 2.02 0 -1.12 0.00017 miRNATAP -0.2 3.0E-5 NA
24 hsa-miR-183-5p AKAP12 2.08 0 -0.93 0.0028 miRNAWalker2 validate; miRTarBase -0.57 0 NA
25 hsa-miR-21-5p AKIRIN1 2.22 0 -0.25 0.00144 miRNATAP -0.11 3.0E-5 NA
26 hsa-miR-21-5p AKT2 2.22 0 -0.16 0.09338 miRNAWalker2 validate -0.13 0.00012 NA
27 hsa-miR-146b-5p AKT3 2.23 0 -0.27 0.18865 miRNAWalker2 validate -0.26 0 NA
28 hsa-miR-200b-3p AMOTL2 2.06 0 0.15 0.30776 TargetScan -0.11 1.0E-5 NA
29 hsa-miR-146b-5p AMPH 2.23 0 -0.92 5.0E-5 PITA -0.35 0 NA
30 hsa-miR-146b-5p ANK2 2.23 0 -1.6 1.0E-5 PITA -0.6 0 NA
31 hsa-miR-200a-3p ANK2 2.02 0 -1.6 1.0E-5 miRNATAP -0.63 0 NA
32 hsa-miR-18a-5p ANKRD50 2.05 0 0.27 0.04034 miRNATAP -0.15 0 NA
33 hsa-miR-192-5p ANKRD6 2.09 0 -0.36 0.03942 miRNAWalker2 validate -0.21 0 NA
34 hsa-miR-200b-3p ANO5 2.06 0 -2.17 0 TargetScan -0.49 0 NA
35 hsa-miR-192-5p ANO6 2.09 0 -0.09 0.50227 miRNAWalker2 validate -0.11 0 NA
36 hsa-miR-200b-3p ANO6 2.06 0 -0.09 0.50227 TargetScan -0.16 0 NA
37 hsa-miR-192-5p AP1S2 2.09 0 -0.61 0.00205 miRNAWalker2 validate -0.34 0 NA
38 hsa-miR-200b-3p AP1S2 2.06 0 -0.61 0.00205 TargetScan -0.41 0 NA
39 hsa-miR-200a-3p APBB2 2.02 0 0.2 0.11714 miRNATAP -0.13 0 NA
40 hsa-miR-192-5p APOLD1 2.09 0 -0.38 0.04851 miRNAWalker2 validate -0.13 2.0E-5 NA
41 hsa-miR-21-5p APOLD1 2.22 0 -0.38 0.04851 miRNAWalker2 validate -0.28 2.0E-5 NA
42 hsa-miR-200a-5p AR 2.19 0 -1.55 0 miRNATAP -0.66 0 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells
43 hsa-miR-200b-3p ARHGAP20 2.06 0 -1.38 0 TargetScan -0.53 0 NA
44 hsa-miR-194-5p ARHGAP24 2.24 0 -0.93 0 miRNATAP -0.16 0 NA
45 hsa-miR-200a-3p ARHGAP24 2.02 0 -0.93 0 miRNATAP -0.21 0 NA
46 hsa-miR-21-5p ARHGAP24 2.22 0 -0.93 0 miRNATAP -0.37 0 NA
47 hsa-miR-196b-5p ARHGAP28 4.52 0 -0.91 0.00013 miRNATAP -0.11 4.0E-5 NA
48 hsa-miR-192-5p ARHGAP29 2.09 0 0.13 0.42953 miRNAWalker2 validate -0.13 0 NA
49 hsa-miR-146b-5p ARHGAP6 2.23 0 -0.53 0.04006 PITA -0.31 0 NA
50 hsa-miR-183-5p ARHGAP6 2.08 0 -0.53 0.04006 miRNATAP -0.41 0 NA
51 hsa-miR-200b-3p ARHGAP6 2.06 0 -0.53 0.04006 TargetScan -0.29 0 NA
52 hsa-miR-192-5p ARHGEF10 2.09 0 -0.1 0.61 miRNAWalker2 validate -0.17 0 NA
53 hsa-miR-200b-3p ARHGEF17 2.06 0 0.03 0.85895 TargetScan -0.34 0 NA
54 hsa-miR-192-5p ARHGEF26 2.09 0 -1.96 0 miRNAWalker2 validate -0.51 0 NA
55 hsa-miR-135b-5p ARHGEF4 2.8 0 -1.41 0.0003 miRNATAP -0.31 0 NA
56 hsa-miR-192-5p ARL2BP 2.09 0 -0.34 3.0E-5 miRNAWalker2 validate -0.11 0 NA
57 hsa-miR-200b-3p ARL2BP 2.06 0 -0.34 3.0E-5 TargetScan -0.11 0 NA
58 hsa-miR-200b-3p ARL3 2.06 0 -0.52 0 TargetScan -0.15 0 NA
59 hsa-miR-133a-3p ARL6IP1 -2.63 0 0.58 1.0E-5 miRNAWalker2 validate -0.14 0 NA
60 hsa-miR-21-5p ARMCX3 2.22 0 -0.17 0.29447 miRNAWalker2 validate -0.12 0.03566 NA
61 hsa-miR-935 ARNT2 2.32 0 -0.33 0.25851 PITA; miRNATAP -0.2 0 NA
62 hsa-miR-200b-3p ARRDC3 2.06 0 -0.15 0.28741 TargetScan -0.12 0 NA
63 hsa-miR-194-5p ASAP1 2.24 0 0.66 0 miRNATAP -0.1 0 NA
64 hsa-miR-200a-3p ASTN1 2.02 0 -2.39 2.0E-5 miRNATAP -0.86 0 NA
65 hsa-miR-200b-3p ASXL3 2.06 0 -1.88 0 TargetScan -0.46 0 NA
66 hsa-miR-192-5p ATF7 2.09 0 0.07 0.43806 miRNATAP -0.11 0 NA
67 hsa-miR-183-5p ATL2 2.08 0 -0.38 0.00058 miRNATAP -0.13 0 NA
68 hsa-miR-200b-3p ATL2 2.06 0 -0.38 0.00058 TargetScan -0.14 0 NA
69 hsa-miR-18a-5p ATM 2.05 0 0.18 0.21568 miRNAWalker2 validate; miRTarBase -0.11 0.00023 23437304; 25963391; 23857602; 23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases
70 hsa-miR-192-5p ATP10D 2.09 0 -0.37 0.00764 miRNAWalker2 validate -0.12 0 NA
71 hsa-miR-183-5p ATP2B4 2.08 0 -0.64 0.00597 miRNATAP -0.5 0 NA
72 hsa-miR-21-5p ATP2B4 2.22 0 -0.64 0.00597 miRNAWalker2 validate -0.5 0 NA
73 hsa-miR-192-5p ATRNL1 2.09 0 -1.69 1.0E-5 miRNAWalker2 validate -0.33 0 NA
74 hsa-miR-146b-3p ATXN1 2.09 0 -0.51 0.00026 miRNATAP -0.14 0.00014 NA
75 hsa-miR-18a-5p ATXN1 2.05 0 -0.51 0.00026 miRNATAP -0.27 0 NA
76 hsa-miR-200a-3p ATXN1 2.02 0 -0.51 0.00026 miRNATAP -0.21 0 NA
77 hsa-miR-200b-3p ATXN1 2.06 0 -0.51 0.00026 TargetScan -0.23 0 NA
78 hsa-miR-18a-5p ATXN1L 2.05 0 -0.07 0.43241 miRNATAP -0.12 0 NA
79 hsa-miR-200b-3p AUTS2 2.06 0 -0.27 0.18068 TargetScan -0.16 1.0E-5 NA
80 hsa-miR-21-5p AUTS2 2.22 0 -0.27 0.18068 miRNAWalker2 validate -0.22 0.00112 NA
81 hsa-miR-192-5p B3GALNT1 2.09 0 0.08 0.70688 miRNAWalker2 validate -0.14 1.0E-5 NA
82 hsa-miR-146b-3p BACE1 2.09 0 -0.1 0.49755 miRNATAP -0.13 0.00052 NA
83 hsa-miR-200a-3p BACE1 2.02 0 -0.1 0.49755 miRNATAP -0.21 0 NA
84 hsa-miR-141-5p BACH2 2.14 0 -0.15 0.55909 miRNATAP -0.31 0 NA
85 hsa-miR-183-5p BACH2 2.08 0 -0.15 0.55909 miRNATAP -0.3 0 NA
86 hsa-miR-200b-3p BACH2 2.06 0 -0.15 0.55909 TargetScan -0.28 0 NA
87 hsa-miR-935 BACH2 2.32 0 -0.15 0.55909 PITA; miRNATAP -0.19 0 NA
88 hsa-miR-21-5p BAHD1 2.22 0 -0.13 0.13262 miRNATAP -0.11 0.00011 NA
89 hsa-miR-18a-5p BBX 2.05 0 0.14 0.22968 miRNATAP -0.12 0 NA
90 hsa-miR-200a-3p BBX 2.02 0 0.14 0.22968 miRNATAP -0.11 0 NA
91 hsa-miR-200b-3p BBX 2.06 0 0.14 0.22968 TargetScan -0.12 0 NA
92 hsa-miR-141-5p BCKDHB 2.14 0 -0.48 0.00034 miRNATAP -0.11 2.0E-5 NA
93 hsa-miR-146b-5p BCL11A 2.23 0 -0.93 0.0063 miRNATAP -0.32 0.00016 NA
94 hsa-miR-196a-5p BCL11A 5.06 0 -0.93 0.0063 miRNAWalker2 validate -0.1 0.01003 NA
95 hsa-miR-192-5p BCL2 2.09 0 -0.9 0 miRNAWalker2 validate -0.22 0 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192
96 hsa-miR-196b-5p BCL2 4.52 0 -0.9 0 miRNAWalker2 validate -0.14 0 NA
97 hsa-miR-200b-3p BCL2 2.06 0 -0.9 0 miRNAWalker2 validate; miRTarBase; TargetScan -0.27 0 NA
98 hsa-miR-21-5p BCL2 2.22 0 -0.9 0 miRNAWalker2 validate; miRTarBase -0.4 0 21468550; 25994220; 25381586; 26555418; 23359184; 22964582; 21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells
99 hsa-miR-133a-3p BCL2L1 -2.63 0 0.54 0.00023 miRNAWalker2 validate -0.11 0 23756231 Furthermore bioinformatic prediction and experimental validation were applied to identify target genes of miR-133a and the results revealed that the anti-tumor effect of miR-133a was probably due to targeting and repressing of Bcl-xL and Mcl-1 expression
100 hsa-miR-183-5p BCL6 2.08 0 -0.21 0.19489 miRNATAP -0.25 0 NA
101 hsa-miR-21-5p BCL6 2.22 0 -0.21 0.19489 miRNAWalker2 validate -0.17 0.00271 NA
102 hsa-miR-21-5p BDH2 2.22 0 -1.2 0 miRNAWalker2 validate -0.28 0 NA
103 hsa-miR-192-5p BGLAP 2.09 0 -0.9 0 miRNAWalker2 validate -0.16 0 NA
104 hsa-miR-18a-5p BHLHE22 2.05 0 0.14 0.61876 miRNATAP -0.34 0 NA
105 hsa-miR-192-5p BHLHE22 2.09 0 0.14 0.61876 miRNATAP -0.25 0 NA
106 hsa-miR-200b-3p BHLHE41 2.06 0 0.35 0.12753 TargetScan -0.16 0.0001 NA
107 hsa-miR-200b-3p BICC1 2.06 0 0.84 0.0014 TargetScan -0.29 0 NA
108 hsa-miR-194-5p BICD2 2.24 0 -0.02 0.88611 miRNATAP -0.22 0 NA
109 hsa-miR-200a-3p BICD2 2.02 0 -0.02 0.88611 miRNATAP -0.17 0 NA
110 hsa-miR-200b-3p BICD2 2.06 0 -0.02 0.88611 TargetScan -0.17 0 NA
111 hsa-miR-935 BMP5 2.32 0 -2.89 0 miRNATAP -0.24 0.00053 NA
112 hsa-miR-192-5p BMPR2 2.09 0 0.21 0.0635 miRNAWalker2 validate -0.1 0 NA
113 hsa-miR-146b-5p BNC1 2.23 0 -1.62 0.00071 miRNATAP -0.24 0.0449 NA
114 hsa-miR-183-5p BNC2 2.08 0 -0.49 0.09988 miRNATAP -0.61 0 NA
115 hsa-miR-200b-3p BNC2 2.06 0 -0.49 0.09988 TargetScan -0.55 0 NA
116 hsa-miR-21-5p BNC2 2.22 0 -0.49 0.09988 miRNATAP -0.36 0.00036 NA
117 hsa-miR-21-5p BOC 2.22 0 -0.91 0.0056 miRNAWalker2 validate -0.63 0 NA
118 hsa-miR-146b-3p BRSK1 2.09 0 -0.59 0.00494 PITA; miRNATAP -0.28 0 NA
119 hsa-miR-21-5p BTBD3 2.22 0 -0.1 0.50084 miRNAWalker2 validate; miRNATAP -0.1 0.03696 NA
120 hsa-miR-21-5p BTBD7 2.22 0 -0.17 0.03473 miRNAWalker2 validate -0.1 0.00018 NA
121 hsa-miR-192-5p BTC 2.09 0 -1.69 0 miRNAWalker2 validate -0.26 0 NA
122 hsa-miR-192-5p BTF3L4 2.09 0 0.18 0.05058 miRNAWalker2 validate -0.1 0 NA
123 hsa-miR-146b-5p BTG2 2.23 0 -1.76 0 miRNATAP -0.45 0 NA
124 hsa-miR-21-5p BTG2 2.22 0 -1.76 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.78 0 24821435 miR 21 regulates N methyl N nitro N' nitrosoguanidine induced gastric tumorigenesis by targeting FASLG and BTG2
125 hsa-miR-18a-5p BVES 2.05 0 -1.51 1.0E-5 miRNAWalker2 validate -0.69 0 NA
126 hsa-miR-196a-5p C14orf28 5.06 0 -0.65 0 miRNATAP -0.1 0 NA
127 hsa-miR-196b-5p C14orf28 4.52 0 -0.65 0 miRNATAP -0.1 0 NA
128 hsa-miR-141-5p C16orf52 2.14 0 -0.07 0.3851 miRNATAP -0.11 0 NA
129 hsa-miR-146b-3p C17orf107 2.09 0 -0.68 0.00061 miRNATAP -0.1 0.04929 NA
130 hsa-miR-192-5p C1QTNF3 2.09 0 -1.29 3.0E-5 miRNAWalker2 validate -0.38 0 NA
131 hsa-miR-192-5p C1orf21 2.09 0 -0.73 9.0E-5 miRNATAP -0.13 1.0E-5 NA
132 hsa-miR-194-5p C1orf21 2.24 0 -0.73 9.0E-5 miRNATAP -0.11 0.00076 NA
133 hsa-miR-200a-3p C1orf21 2.02 0 -0.73 9.0E-5 miRNATAP -0.2 0 NA
134 hsa-miR-935 C2orf88 2.32 0 -1.52 0 miRNATAP -0.16 3.0E-5 NA
135 hsa-miR-141-5p C5orf24 2.14 0 0.08 0.41066 miRNATAP -0.1 0 NA
136 hsa-miR-192-5p CAB39L 2.09 0 -1.77 0 miRNAWalker2 validate -0.4 0 NA
137 hsa-miR-200b-3p CACHD1 2.06 0 -0.32 0.13899 TargetScan -0.14 0.00048 NA
138 hsa-miR-200b-3p CACNA1C 2.06 0 -0.18 0.557 TargetScan -0.53 0 NA
139 hsa-miR-200a-3p CACNA1E 2.02 0 1.75 0 miRNATAP -0.17 0.00874 NA
140 hsa-miR-200b-3p CACNA2D1 2.06 0 -0.85 0.00675 TargetScan -0.43 0 NA
141 hsa-miR-935 CACNA2D2 2.32 0 -1.24 0 PITA; miRNATAP -0.24 0 NA
142 hsa-miR-146b-3p CACNB2 2.09 0 -1.06 0.00045 miRNATAP -0.51 0 NA
143 hsa-miR-183-5p CACNB4 2.08 0 -1.06 0.0002 miRNATAP -0.34 0 NA
144 hsa-miR-196a-5p CACNB4 5.06 0 -1.06 0.0002 miRNATAP -0.11 0.00122 NA
145 hsa-miR-196b-5p CACNB4 4.52 0 -1.06 0.0002 miRNATAP -0.12 7.0E-5 NA
146 hsa-miR-146b-5p CADM1 2.23 0 -0.9 0.00084 PITA -0.35 0 NA
147 hsa-miR-192-5p CADM1 2.09 0 -0.9 0.00084 miRNAWalker2 validate -0.26 0 NA
148 hsa-miR-194-5p CADM1 2.24 0 -0.9 0.00084 miRNATAP -0.28 0 NA
149 hsa-miR-200b-3p CADM1 2.06 0 -0.9 0.00084 TargetScan -0.26 0 NA
150 hsa-miR-196a-5p CADM2 5.06 0 -3.78 0 miRNATAP -0.43 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 NEUROGENESIS 216 1402 5.821e-43 2.709e-39
2 CELL DEVELOPMENT 211 1426 3.724e-39 8.664e-36
3 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 222 1672 6.578e-34 1.02e-30
4 REGULATION OF CELL DIFFERENTIATION 204 1492 8.596e-33 9.999e-30
5 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 130 750 1.392e-30 1.295e-27
6 REGULATION OF NEURON DIFFERENTIATION 106 554 1.166e-28 9.04e-26
7 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 101 513 2.247e-28 1.493e-25
8 REGULATION OF CELL DEVELOPMENT 134 836 5.143e-28 2.992e-25
9 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 172 1275 8.662e-27 4.478e-24
10 CELLULAR COMPONENT MORPHOGENESIS 136 900 7.428e-26 3.456e-23
11 CARDIOVASCULAR SYSTEM DEVELOPMENT 125 788 1.006e-25 3.901e-23
12 CIRCULATORY SYSTEM DEVELOPMENT 125 788 1.006e-25 3.901e-23
13 NEURON DIFFERENTIATION 132 874 4.453e-25 1.594e-22
14 NEURON PROJECTION DEVELOPMENT 99 545 5.397e-25 1.794e-22
15 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 145 1021 8.932e-25 2.771e-22
16 CENTRAL NERVOUS SYSTEM DEVELOPMENT 131 872 1.137e-24 3.306e-22
17 NEURON DEVELOPMENT 113 687 1.234e-24 3.376e-22
18 TISSUE DEVELOPMENT 187 1518 2.529e-24 6.537e-22
19 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 154 1142 6.188e-24 1.515e-21
20 NEURON PROJECTION MORPHOGENESIS 80 402 5.841e-23 1.338e-20
21 HEAD DEVELOPMENT 112 709 6.04e-23 1.338e-20
22 CELL PROJECTION ORGANIZATION 129 902 2.442e-22 5.165e-20
23 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 203 1784 3.729e-22 7.544e-20
24 REGULATION OF CELL PROJECTION ORGANIZATION 95 558 6.521e-22 1.233e-19
25 REGULATION OF NEURON PROJECTION DEVELOPMENT 79 408 6.626e-22 1.233e-19
26 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 74 368 1.349e-21 2.415e-19
27 RESPONSE TO ENDOGENOUS STIMULUS 174 1450 2.35e-21 4.05e-19
28 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 136 1008 3.578e-21 5.945e-19
29 LOCOMOTION 144 1114 1.251e-20 2.007e-18
30 REGULATION OF CELL MORPHOGENESIS 91 552 4.713e-20 7.31e-18
31 POSITIVE REGULATION OF NEURON DIFFERENTIATION 64 306 9.304e-20 1.397e-17
32 POSITIVE REGULATION OF CELL DIFFERENTIATION 116 823 1.248e-19 1.814e-17
33 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 165 1395 1.313e-19 1.852e-17
34 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 78 437 2.049e-19 2.805e-17
35 POSITIVE REGULATION OF CELL DEVELOPMENT 81 472 4.86e-19 6.461e-17
36 REGULATION OF PHOSPHORUS METABOLIC PROCESS 181 1618 6.529e-19 8.438e-17
37 CELL PART MORPHOGENESIS 95 633 4.856e-18 6.04e-16
38 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 61 303 4.932e-18 6.04e-16
39 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 110 801 8.371e-18 9.987e-16
40 HEART DEVELOPMENT 78 466 1.002e-17 1.166e-15
41 CELL MOTILITY 112 835 2.4e-17 2.659e-15
42 LOCALIZATION OF CELL 112 835 2.4e-17 2.659e-15
43 ORGAN MORPHOGENESIS 112 841 4.082e-17 4.417e-15
44 VASCULATURE DEVELOPMENT 77 469 5.052e-17 5.342e-15
45 INTRACELLULAR SIGNAL TRANSDUCTION 171 1572 1.124e-16 1.137e-14
46 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 102 740 1.112e-16 1.137e-14
47 POSITIVE REGULATION OF GENE EXPRESSION 183 1733 1.554e-16 1.539e-14
48 REGULATION OF CELLULAR COMPONENT MOVEMENT 104 771 2.461e-16 2.386e-14
49 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 62 337 2.545e-16 2.416e-14
50 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 50 232 2.841e-16 2.644e-14
51 BEHAVIOR 80 516 3.612e-16 3.295e-14
52 REGULATION OF PROTEIN MODIFICATION PROCESS 180 1710 3.962e-16 3.545e-14
53 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 123 1004 7.173e-16 6.297e-14
54 SINGLE ORGANISM BEHAVIOR 66 384 9.247e-16 7.823e-14
55 NEGATIVE REGULATION OF CELL DIFFERENTIATION 88 609 9.218e-16 7.823e-14
56 REGULATION OF SYSTEM PROCESS 78 507 1.33e-15 1.105e-13
57 TUBE DEVELOPMENT 82 552 1.881e-15 1.536e-13
58 RESPONSE TO HORMONE 112 893 3.113e-15 2.497e-13
59 RESPONSE TO GROWTH FACTOR 74 475 3.73e-15 2.942e-13
60 EPITHELIUM DEVELOPMENT 116 945 4.514e-15 3.501e-13
61 MUSCLE STRUCTURE DEVELOPMENT 69 432 9.254e-15 6.964e-13
62 NEURON MIGRATION 32 110 9.28e-15 6.964e-13
63 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 132 1152 1.125e-14 8.312e-13
64 REGULATION OF TRANSPORT 182 1804 1.599e-14 1.162e-12
65 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 182 1805 1.685e-14 1.206e-12
66 MESENCHYME DEVELOPMENT 42 190 2.749e-14 1.938e-12
67 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 184 1848 3.864e-14 2.684e-12
68 NEGATIVE REGULATION OF GENE EXPRESSION 157 1493 4.613e-14 3.157e-12
69 REGULATION OF CELL DEATH 155 1472 6.145e-14 4.144e-12
70 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 91 689 7.238e-14 4.811e-12
71 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 158 1517 8.514e-14 5.58e-12
72 REGULATION OF CELL PROLIFERATION 156 1496 1.136e-13 7.344e-12
73 POSITIVE REGULATION OF MOLECULAR FUNCTION 178 1791 1.299e-13 8.277e-12
74 REGULATION OF DEVELOPMENTAL GROWTH 52 289 1.694e-13 1.057e-11
75 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 115 983 1.704e-13 1.057e-11
76 REGULATION OF AXONOGENESIS 38 168 2.166e-13 1.326e-11
77 ACTIN FILAMENT BASED PROCESS 68 450 2.252e-13 1.361e-11
78 MODULATION OF SYNAPTIC TRANSMISSION 53 301 2.433e-13 1.451e-11
79 REGULATION OF CELLULAR COMPONENT BIOGENESIS 96 767 3.868e-13 2.278e-11
80 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 118 1036 5.06e-13 2.871e-11
81 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 166 1656 4.939e-13 2.871e-11
82 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 118 1036 5.06e-13 2.871e-11
83 TISSUE MORPHOGENESIS 75 533 5.273e-13 2.956e-11
84 FOREBRAIN DEVELOPMENT 58 357 6.303e-13 3.492e-11
85 UROGENITAL SYSTEM DEVELOPMENT 52 299 6.767e-13 3.704e-11
86 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 111 957 8.196e-13 4.435e-11
87 MORPHOGENESIS OF AN EPITHELIUM 62 400 8.493e-13 4.542e-11
88 TELENCEPHALON DEVELOPMENT 44 228 1.05e-12 5.551e-11
89 TUBE MORPHOGENESIS 54 323 1.246e-12 6.513e-11
90 SYNAPSE ORGANIZATION 34 145 1.335e-12 6.904e-11
91 EMBRYO DEVELOPMENT 105 894 1.65e-12 8.437e-11
92 NEURON PROJECTION GUIDANCE 41 205 1.855e-12 9.381e-11
93 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 44 232 1.959e-12 9.803e-11
94 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 47 262 2.793e-12 1.383e-10
95 CELLULAR RESPONSE TO HORMONE STIMULUS 75 552 3.088e-12 1.513e-10
96 MESENCHYMAL CELL DIFFERENTIATION 32 134 3.598e-12 1.744e-10
97 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 96 799 4.312e-12 2.068e-10
98 BLOOD VESSEL MORPHOGENESIS 57 364 4.702e-12 2.233e-10
99 DENDRITE DEVELOPMENT 24 79 7.267e-12 3.416e-10
100 COGNITION 45 251 8.315e-12 3.869e-10
101 RESPONSE TO OXYGEN CONTAINING COMPOUND 141 1381 9.77e-12 4.501e-10
102 REGULATION OF EXTENT OF CELL GROWTH 27 101 1.032e-11 4.707e-10
103 ACTION POTENTIAL 26 94 1.066e-11 4.818e-10
104 REGULATION OF KINASE ACTIVITY 93 776 1.098e-11 4.911e-10
105 POSITIVE REGULATION OF CATALYTIC ACTIVITY 151 1518 1.196e-11 5.302e-10
106 REGULATION OF ACTIN FILAMENT BASED PROCESS 51 312 1.255e-11 5.51e-10
107 NEGATIVE REGULATION OF CELL DEVELOPMENT 50 303 1.4e-11 6.031e-10
108 REGULATION OF MEMBRANE POTENTIAL 54 343 1.398e-11 6.031e-10
109 PROTEIN PHOSPHORYLATION 106 944 2.032e-11 8.673e-10
110 REGULATION OF HEART CONTRACTION 41 221 2.306e-11 9.756e-10
111 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 34 162 3.615e-11 1.515e-09
112 RESPIRATORY SYSTEM DEVELOPMENT 38 197 3.731e-11 1.55e-09
113 DEVELOPMENTAL GROWTH 52 333 4.563e-11 1.879e-09
114 DENDRITE MORPHOGENESIS 17 42 4.733e-11 1.932e-09
115 EMBRYONIC MORPHOGENESIS 71 539 5.053e-11 2.027e-09
116 STEM CELL DIFFERENTIATION 37 190 5.051e-11 2.027e-09
117 CARDIAC MUSCLE CELL ACTION POTENTIAL 16 37 5.27e-11 2.096e-09
118 MUSCLE CELL DIFFERENTIATION 42 237 6.049e-11 2.365e-09
119 NEGATIVE REGULATION OF CELL COMMUNICATION 124 1192 6.041e-11 2.365e-09
120 GROWTH 59 410 6.812e-11 2.641e-09
121 REGULATION OF CELLULAR COMPONENT SIZE 52 337 7.158e-11 2.753e-09
122 NEGATIVE REGULATION OF CELL DEATH 98 872 1.172e-10 4.471e-09
123 RESPONSE TO OXYGEN LEVELS 49 311 1.206e-10 4.562e-09
124 RESPONSE TO ABIOTIC STIMULUS 110 1024 1.229e-10 4.611e-09
125 NEGATIVE REGULATION OF CELL PROLIFERATION 79 643 1.28e-10 4.767e-09
126 CARDIAC MUSCLE CELL CONTRACTION 14 29 1.374e-10 5.073e-09
127 MUSCLE TISSUE DEVELOPMENT 45 275 1.956e-10 7.166e-09
128 REGULATION OF GTPASE ACTIVITY 81 673 2.039e-10 7.41e-09
129 SKELETAL SYSTEM DEVELOPMENT 62 455 2.191e-10 7.902e-09
130 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 36 191 2.399e-10 8.588e-09
131 SYNAPTIC SIGNALING 59 424 2.632e-10 9.349e-09
132 REGULATION OF SYNAPTIC PLASTICITY 30 140 2.989e-10 1.054e-08
133 POSITIVE REGULATION OF CELL PROLIFERATION 92 814 3.349e-10 1.172e-08
134 REGULATION OF GROWTH 77 633 3.538e-10 1.229e-08
135 CELL CELL SIGNALING 88 767 3.886e-10 1.339e-08
136 MUSCLE SYSTEM PROCESS 45 282 4.532e-10 1.551e-08
137 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 65 498 4.954e-10 1.683e-08
138 POSITIVE REGULATION OF CELL COMMUNICATION 146 1532 5.827e-10 1.965e-08
139 REGULATION OF BLOOD CIRCULATION 46 295 6.32e-10 2.116e-08
140 REGULATION OF EPITHELIAL CELL PROLIFERATION 45 285 6.432e-10 2.138e-08
141 PALLIUM DEVELOPMENT 31 153 6.626e-10 2.187e-08
142 CYTOSKELETON ORGANIZATION 93 838 6.949e-10 2.277e-08
143 HINDBRAIN DEVELOPMENT 29 137 7.998e-10 2.602e-08
144 REGULATION OF TRANSMEMBRANE TRANSPORT 58 426 8.709e-10 2.814e-08
145 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 29 138 9.578e-10 3.074e-08
146 STRIATED MUSCLE CELL DIFFERENTIATION 33 173 9.702e-10 3.076e-08
147 REGULATION OF ANATOMICAL STRUCTURE SIZE 62 472 9.719e-10 3.076e-08
148 POSITIVE REGULATION OF AXONOGENESIS 20 69 1.03e-09 3.238e-08
149 REGULATION OF CELLULAR LOCALIZATION 126 1277 1.236e-09 3.86e-08
150 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 83 724 1.302e-09 4.026e-08
151 MULTICELLULAR ORGANISMAL SIGNALING 27 123 1.306e-09 4.026e-08
152 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 132 1360 1.372e-09 4.146e-08
153 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 20 70 1.365e-09 4.146e-08
154 REGULATION OF ION TRANSPORT 72 592 1.356e-09 4.146e-08
155 CONNECTIVE TISSUE DEVELOPMENT 35 194 1.448e-09 4.347e-08
156 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 115 1135 1.53e-09 4.564e-08
157 REGULATION OF HYDROLASE ACTIVITY 129 1327 1.957e-09 5.801e-08
158 REGULATION OF TRANSFERASE ACTIVITY 100 946 2.158e-09 6.315e-08
159 SYSTEM PROCESS 162 1785 2.148e-09 6.315e-08
160 EPITHELIAL CELL DIFFERENTIATION 63 495 2.527e-09 7.35e-08
161 AMEBOIDAL TYPE CELL MIGRATION 30 154 3.32e-09 9.536e-08
162 REGULATION OF CELL SIZE 32 172 3.315e-09 9.536e-08
163 POSITIVE REGULATION OF LOCOMOTION 56 420 3.684e-09 1.052e-07
164 BONE DEVELOPMENT 30 156 4.56e-09 1.286e-07
165 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 30 156 4.56e-09 1.286e-07
166 RESPONSE TO WOUNDING 68 563 5.227e-09 1.465e-07
167 REGULATION OF CELL GROWTH 53 391 5.444e-09 1.517e-07
168 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 27 131 5.628e-09 1.559e-07
169 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 66 541 5.911e-09 1.618e-07
170 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 66 541 5.911e-09 1.618e-07
171 BIOLOGICAL ADHESION 105 1032 6.691e-09 1.821e-07
172 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 42 278 9.111e-09 2.465e-07
173 ACTIN FILAMENT BASED MOVEMENT 22 93 1.012e-08 2.722e-07
174 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 28 144 1.149e-08 3.073e-07
175 CELL PROLIFERATION 76 672 1.195e-08 3.179e-07
176 REGULATION OF MAPK CASCADE 75 660 1.22e-08 3.226e-07
177 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 138 1492 1.238e-08 3.254e-07
178 RESPONSE TO ORGANIC CYCLIC COMPOUND 95 917 1.523e-08 3.981e-07
179 CARTILAGE DEVELOPMENT 28 147 1.843e-08 4.79e-07
180 GLIOGENESIS 31 175 1.943e-08 5.023e-07
181 PHOSPHORYLATION 118 1228 1.974e-08 5.075e-07
182 TAXIS 58 464 2.098e-08 5.363e-07
183 CEREBRAL CORTEX DEVELOPMENT 23 105 2.25e-08 5.72e-07
184 MORPHOGENESIS OF A BRANCHING STRUCTURE 30 167 2.357e-08 5.959e-07
185 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 171 1977 2.371e-08 5.963e-07
186 CARDIAC CONDUCTION 20 82 2.704e-08 6.763e-07
187 SENSORY ORGAN DEVELOPMENT 60 493 3.196e-08 7.953e-07
188 CELLULAR RESPONSE TO NITROGEN COMPOUND 61 505 3.236e-08 7.966e-07
189 POSITIVE REGULATION OF GROWTH 37 238 3.222e-08 7.966e-07
190 SECOND MESSENGER MEDIATED SIGNALING 29 160 3.277e-08 8.025e-07
191 POSITIVE REGULATION OF KINASE ACTIVITY 59 482 3.388e-08 8.254e-07
192 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 36 229 3.679e-08 8.917e-07
193 KIDNEY EPITHELIUM DEVELOPMENT 25 125 3.859e-08 9.302e-07
194 SMOOTH MUSCLE CELL DIFFERENTIATION 12 30 4.06e-08 9.737e-07
195 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 20 84 4.188e-08 9.993e-07
196 RESPONSE TO NITROGEN COMPOUND 89 859 4.42e-08 1.049e-06
197 CARDIAC CHAMBER DEVELOPMENT 27 144 4.651e-08 1.099e-06
198 NEGATIVE REGULATION OF LOCOMOTION 39 263 5.138e-08 1.208e-06
199 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 106 1087 5.229e-08 1.223e-06
200 HEART MORPHOGENESIS 34 212 5.309e-08 1.235e-06
201 POSITIVE REGULATION OF HYDROLASE ACTIVITY 92 905 6.34e-08 1.468e-06
202 NEGATIVE REGULATION OF PHOSPHORYLATION 53 422 7.3e-08 1.681e-06
203 REGULATION OF EPITHELIAL CELL MIGRATION 29 166 7.579e-08 1.737e-06
204 DIGESTIVE SYSTEM DEVELOPMENT 27 148 8.418e-08 1.92e-06
205 CARDIAC MUSCLE TISSUE DEVELOPMENT 26 140 1.004e-07 2.278e-06
206 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 33 208 1.081e-07 2.441e-06
207 REGULATION OF METAL ION TRANSPORT 44 325 1.115e-07 2.505e-06
208 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 74 684 1.154e-07 2.583e-06
209 CENTRAL NERVOUS SYSTEM NEURON AXONOGENESIS 11 27 1.203e-07 2.678e-06
210 LUNG MORPHOGENESIS 14 45 1.241e-07 2.75e-06
211 CELL CELL SIGNALING INVOLVED IN CARDIAC CONDUCTION 10 22 1.302e-07 2.87e-06
212 GLAND DEVELOPMENT 50 395 1.335e-07 2.925e-06
213 NEPHRON DEVELOPMENT 23 115 1.339e-07 2.925e-06
214 REGULATION OF NEUROTRANSMITTER LEVELS 31 190 1.369e-07 2.976e-06
215 ACTIN MEDIATED CELL CONTRACTION 18 74 1.393e-07 3.014e-06
216 ENDOTHELIUM DEVELOPMENT 20 90 1.43e-07 3.081e-06
217 WOUND HEALING 56 470 1.879e-07 4.01e-06
218 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 56 470 1.879e-07 4.01e-06
219 MUSCLE ORGAN DEVELOPMENT 39 277 2.083e-07 4.426e-06
220 CELL JUNCTION ORGANIZATION 30 185 2.489e-07 5.24e-06
221 REGULATION OF MUSCLE SYSTEM PROCESS 31 195 2.488e-07 5.24e-06
222 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 8 14 2.567e-07 5.379e-06
223 HEART PROCESS 19 85 2.648e-07 5.525e-06
224 RESPONSE TO PEPTIDE 50 404 2.686e-07 5.579e-06
225 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 28 166 2.698e-07 5.579e-06
226 PEPTIDYL TYROSINE MODIFICATION 30 186 2.807e-07 5.779e-06
227 REGULATION OF DENDRITE DEVELOPMENT 23 120 3.005e-07 6.159e-06
228 EMBRYONIC ORGAN DEVELOPMENT 50 406 3.126e-07 6.379e-06
229 REGULATION OF HEART RATE 19 86 3.218e-07 6.538e-06
230 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 67 616 3.811e-07 7.71e-06
231 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 21 104 3.933e-07 7.923e-06
232 REGULATION OF SYNAPSE ORGANIZATION 22 113 4.077e-07 8.177e-06
233 POSITIVE REGULATION OF AXON EXTENSION 12 36 4.258e-07 8.504e-06
234 CARDIOCYTE DIFFERENTIATION 20 96 4.362e-07 8.673e-06
235 REGULATION OF ORGAN MORPHOGENESIS 35 242 4.535e-07 8.98e-06
236 ENDOTHELIAL CELL DIFFERENTIATION 17 72 4.883e-07 9.628e-06
237 CIRCULATORY SYSTEM PROCESS 46 366 5.173e-07 1.016e-05
238 RHYTHMIC PROCESS 40 298 5.231e-07 1.023e-05
239 REGULATION OF WNT SIGNALING PATHWAY 41 310 5.619e-07 1.094e-05
240 REGULATION OF CELL SUBSTRATE ADHESION 28 173 6.453e-07 1.251e-05
241 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 25 144 6.66e-07 1.286e-05
242 MESONEPHROS DEVELOPMENT 19 90 6.797e-07 1.307e-05
243 CELL CYCLE ARREST 26 154 7.003e-07 1.335e-05
244 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 26 154 7.003e-07 1.335e-05
245 ADULT BEHAVIOR 24 135 7.101e-07 1.349e-05
246 NEGATIVE REGULATION OF GROWTH 34 236 7.225e-07 1.361e-05
247 REGULATION OF CYTOSKELETON ORGANIZATION 57 502 7.214e-07 1.361e-05
248 CARDIAC MUSCLE CELL DIFFERENTIATION 17 74 7.41e-07 1.39e-05
249 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 49 406 7.472e-07 1.396e-05
250 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 22 117 7.618e-07 1.418e-05
251 VASCULOGENESIS 15 59 8.268e-07 1.533e-05
252 NEURAL CREST CELL DIFFERENTIATION 17 75 9.074e-07 1.675e-05
253 MUSCLE CELL DEVELOPMENT 23 128 9.913e-07 1.823e-05
254 POSITIVE REGULATION OF TRANSPORT 90 936 1.024e-06 1.876e-05
255 REGULATION OF CELL JUNCTION ASSEMBLY 16 68 1.109e-06 2.008e-05
256 REGULATION OF TRANSPORTER ACTIVITY 30 198 1.102e-06 2.008e-05
257 ORGAN GROWTH 16 68 1.109e-06 2.008e-05
258 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 12 39 1.133e-06 2.036e-05
259 POSITIVE REGULATION OF CELL GROWTH 25 148 1.129e-06 2.036e-05
260 REGULATION OF OSSIFICATION 28 178 1.164e-06 2.082e-05
261 CELLULAR RESPONSE TO PEPTIDE 37 274 1.195e-06 2.131e-05
262 CYCLIC NUCLEOTIDE MEDIATED SIGNALING 13 46 1.205e-06 2.14e-05
263 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 51 437 1.229e-06 2.175e-05
264 DEVELOPMENTAL CELL GROWTH 17 77 1.345e-06 2.371e-05
265 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 20 103 1.418e-06 2.489e-05
266 LEARNING 23 131 1.507e-06 2.636e-05
267 MUSCLE CONTRACTION 33 233 1.543e-06 2.689e-05
268 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 53 465 1.571e-06 2.728e-05
269 POSITIVE REGULATION OF RESPONSE TO STIMULUS 159 1929 1.594e-06 2.757e-05
270 FOREBRAIN CELL MIGRATION 15 62 1.639e-06 2.814e-05
271 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 65 616 1.634e-06 2.814e-05
272 CALCIUM ION TRANSPORT 32 223 1.658e-06 2.837e-05
273 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 60 554 1.78e-06 3.034e-05
274 POSITIVE REGULATION OF CELL DEATH 64 605 1.805e-06 3.065e-05
275 REGULATION OF POSTSYNAPTIC MEMBRANE POTENTIAL 14 55 1.886e-06 3.191e-05
276 REGULATION OF CARTILAGE DEVELOPMENT 15 63 2.038e-06 3.435e-05
277 LUNG ALVEOLUS DEVELOPMENT 12 41 2.056e-06 3.454e-05
278 CELLULAR RESPONSE TO LIPID 52 457 2.07e-06 3.464e-05
279 NEGATIVE REGULATION OF CELL CYCLE 50 433 2.124e-06 3.542e-05
280 POSITIVE REGULATION OF MAPK CASCADE 53 470 2.168e-06 3.602e-05
281 RESPONSE TO ALCOHOL 44 362 2.251e-06 3.727e-05
282 ANGIOGENESIS 38 293 2.334e-06 3.851e-05
283 REGULATION OF DENDRITIC SPINE DEVELOPMENT 14 56 2.383e-06 3.918e-05
284 RESPONSE TO LIPID 85 888 2.471e-06 4.048e-05
285 CELL GROWTH 23 135 2.576e-06 4.206e-05
286 NEUROTROPHIN SIGNALING PATHWAY 9 23 2.612e-06 4.249e-05
287 MEMORY 19 98 2.646e-06 4.29e-05
288 AUTONOMIC NERVOUS SYSTEM DEVELOPMENT 12 42 2.729e-06 4.409e-05
289 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 10 29 2.785e-06 4.483e-05
290 METANEPHROS DEVELOPMENT 17 81 2.833e-06 4.545e-05
291 GLIAL CELL DIFFERENTIATION 23 136 2.934e-06 4.692e-05
292 OSSIFICATION 34 251 2.983e-06 4.753e-05
293 REGULATION OF COLLATERAL SPROUTING 8 18 3.039e-06 4.81e-05
294 REGULATION OF ORGAN GROWTH 16 73 3.032e-06 4.81e-05
295 KIDNEY MORPHOGENESIS 17 82 3.384e-06 5.338e-05
296 ENSHEATHMENT OF NEURONS 18 91 3.575e-06 5.601e-05
297 AXON ENSHEATHMENT 18 91 3.575e-06 5.601e-05
298 CEREBRAL CORTEX CELL MIGRATION 12 43 3.588e-06 5.602e-05
299 REGULATION OF HEART RATE BY CARDIAC CONDUCTION 10 30 3.962e-06 6.151e-05
300 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 9 24 3.966e-06 6.151e-05
301 CELL JUNCTION ASSEMBLY 22 129 4.155e-06 6.423e-05
302 REGULATION OF SECRETION 70 699 4.214e-06 6.492e-05
303 IMMUNE SYSTEM DEVELOPMENT 61 582 4.232e-06 6.498e-05
304 NEURAL CREST CELL MIGRATION 13 51 4.31e-06 6.576e-05
305 REGULATION OF ORGANELLE ORGANIZATION 105 1178 4.311e-06 6.576e-05
306 ARTERY DEVELOPMENT 16 75 4.412e-06 6.708e-05
307 CELL COMMUNICATION INVOLVED IN CARDIAC CONDUCTION 11 37 4.632e-06 6.997e-05
308 CAMP MEDIATED SIGNALING 11 37 4.632e-06 6.997e-05
309 TISSUE MIGRATION 17 84 4.785e-06 7.206e-05
310 EMBRYONIC ORGAN MORPHOGENESIS 36 279 4.803e-06 7.21e-05
311 RENAL SYSTEM PROCESS 19 102 4.917e-06 7.356e-05
312 NEPHRON EPITHELIUM DEVELOPMENT 18 93 4.942e-06 7.37e-05
313 VENTRICULAR CARDIAC MUSCLE CELL DIFFERENTIATION 8 19 4.985e-06 7.41e-05
314 LOCOMOTORY BEHAVIOR 27 181 5.05e-06 7.483e-05
315 SINGLE ORGANISM CELL ADHESION 51 459 5.128e-06 7.575e-05
316 RESPONSE TO EXTERNAL STIMULUS 149 1821 5.318e-06 7.805e-05
317 REGULATION OF NEURON APOPTOTIC PROCESS 28 192 5.306e-06 7.805e-05
318 WNT SIGNALING PATHWAY 42 351 5.651e-06 8.237e-05
319 PALATE DEVELOPMENT 17 85 5.665e-06 8.237e-05
320 POSITIVE REGULATION OF ION TRANSPORT 32 236 5.655e-06 8.237e-05
321 REGULATION OF MUSCLE TISSUE DEVELOPMENT 19 103 5.708e-06 8.274e-05
322 ENDOTHELIAL CELL DEVELOPMENT 12 45 6.046e-06 8.736e-05
323 MAINTENANCE OF CELL NUMBER 22 132 6.117e-06 8.812e-05
324 REGULATION OF CELL ADHESION 64 629 6.526e-06 9.372e-05
325 CARDIAC CHAMBER MORPHOGENESIS 19 104 6.613e-06 9.467e-05
326 SYNAPSE ASSEMBLY 15 69 6.836e-06 9.757e-05
327 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 27 184 6.907e-06 9.828e-05
328 MEMBRANE DEPOLARIZATION 14 61 7.057e-06 0.0001001
329 RENAL TUBULE DEVELOPMENT 16 78 7.541e-06 0.0001067
330 INOSITOL LIPID MEDIATED SIGNALING 21 124 7.642e-06 0.0001078
331 REGULATION OF CHONDROCYTE DIFFERENTIATION 12 46 7.754e-06 0.000109
332 PROTEIN LOCALIZATION 147 1805 7.961e-06 0.0001116
333 CELLULAR RESPONSE TO ACID CHEMICAL 26 175 8.088e-06 0.0001127
334 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 29 207 8.085e-06 0.0001127
335 NEURAL PRECURSOR CELL PROLIFERATION 15 70 8.243e-06 0.0001141
336 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 15 70 8.243e-06 0.0001141
337 NEGATIVE REGULATION OF SYNAPTIC TRANSMISSION 14 62 8.638e-06 0.0001193
338 CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 7 15 8.729e-06 0.0001195
339 NEUROTRANSMITTER TRANSPORT 24 155 8.734e-06 0.0001195
340 PATTERN SPECIFICATION PROCESS 47 418 8.711e-06 0.0001195
341 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 30 220 9.797e-06 0.0001337
342 EMBRYONIC DIGESTIVE TRACT DEVELOPMENT 10 33 1.042e-05 0.0001418
343 ADULT LOCOMOTORY BEHAVIOR 16 80 1.061e-05 0.0001439
344 RESPONSE TO MECHANICAL STIMULUS 29 210 1.072e-05 0.000145
345 REGULATION OF MUSCLE CONTRACTION 23 147 1.12e-05 0.0001511
346 REGULATION OF HOMEOSTATIC PROCESS 49 447 1.127e-05 0.0001516
347 NEGATIVE REGULATION OF ORGAN GROWTH 8 21 1.21e-05 0.0001617
348 SYMPATHETIC NERVOUS SYSTEM DEVELOPMENT 8 21 1.21e-05 0.0001617
349 EYE DEVELOPMENT 39 326 1.213e-05 0.0001617
350 STRIATED MUSCLE CONTRACTION 18 99 1.23e-05 0.0001631
351 LIPID PHOSPHORYLATION 18 99 1.23e-05 0.0001631
352 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 12 48 1.248e-05 0.0001645
353 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORT 12 48 1.248e-05 0.0001645
354 DIVALENT INORGANIC CATION TRANSPORT 34 268 1.258e-05 0.0001654
355 REGULATION OF NEUROTRANSMITTER TRANSPORT 14 64 1.276e-05 0.0001673
356 APPENDAGE DEVELOPMENT 25 169 1.295e-05 0.0001688
357 LIMB DEVELOPMENT 25 169 1.295e-05 0.0001688
358 REGULATION OF RHO PROTEIN SIGNAL TRANSDUCTION 19 109 1.338e-05 0.0001739
359 HIPPOCAMPUS DEVELOPMENT 15 73 1.413e-05 0.0001831
360 METENCEPHALON DEVELOPMENT 18 100 1.421e-05 0.0001831
361 LIMBIC SYSTEM DEVELOPMENT 18 100 1.421e-05 0.0001831
362 NEURON CELL CELL ADHESION 7 16 1.475e-05 0.0001895
363 PROTEIN AUTOPHOSPHORYLATION 27 192 1.53e-05 0.0001961
364 NEGATIVE REGULATION OF AXONOGENESIS 14 65 1.542e-05 0.0001971
365 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 12 49 1.567e-05 0.0001986
366 GLOMERULUS DEVELOPMENT 12 49 1.567e-05 0.0001986
367 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 12 49 1.567e-05 0.0001986
368 NEGATIVE REGULATION OF NEURON DEATH 25 171 1.593e-05 0.0002014
369 MUSCLE HYPERTROPHY 9 28 1.7e-05 0.0002144
370 BONE CELL DEVELOPMENT 8 22 1.806e-05 0.0002265
371 CENTRAL NERVOUS SYSTEM PROJECTION NEURON AXONOGENESIS 8 22 1.806e-05 0.0002265
372 REGULATION OF BODY FLUID LEVELS 53 506 1.818e-05 0.000227
373 REGULATION OF PROTEIN IMPORT 26 183 1.819e-05 0.000227
374 SOMATIC STEM CELL POPULATION MAINTENANCE 14 66 1.854e-05 0.0002301
375 REGULATION OF CARDIAC MUSCLE CONTRACTION 14 66 1.854e-05 0.0002301
376 REGULATION OF OSTEOBLAST DIFFERENTIATION 19 112 1.995e-05 0.0002469
377 NEGATIVE REGULATION OF MOLECULAR FUNCTION 95 1079 2.046e-05 0.0002525
378 SINGLE ORGANISM CELLULAR LOCALIZATION 82 898 2.138e-05 0.0002632
379 REGULATION OF MUSCLE ORGAN DEVELOPMENT 18 103 2.161e-05 0.0002653
380 REGULATION OF NEURON DEATH 32 252 2.2e-05 0.0002693
381 RESPONSE TO STEROID HORMONE 52 497 2.242e-05 0.0002737
382 CELLULAR RESPONSE TO OXYGEN LEVELS 22 143 2.262e-05 0.0002755
383 RESPONSE TO BMP 17 94 2.29e-05 0.0002775
384 CELLULAR RESPONSE TO BMP STIMULUS 17 94 2.29e-05 0.0002775
385 STEM CELL DIVISION 9 29 2.34e-05 0.0002828
386 CARDIAC SEPTUM DEVELOPMENT 16 85 2.361e-05 0.0002846
387 NERVE DEVELOPMENT 14 68 2.651e-05 0.0003187
388 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 80 876 2.685e-05 0.000322
389 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 21 135 2.909e-05 0.000348
390 CELL CELL ADHESION 60 608 3.136e-05 0.0003742
391 MEMBRANE BIOGENESIS 9 30 3.172e-05 0.0003752
392 GLIAL CELL MIGRATION 10 37 3.177e-05 0.0003752
393 REGULATION OF DENDRITIC SPINE MORPHOGENESIS 9 30 3.172e-05 0.0003752
394 AXON EXTENSION 10 37 3.177e-05 0.0003752
395 CARDIAC VENTRICLE DEVELOPMENT 18 106 3.227e-05 0.0003801
396 REGULATION OF ION HOMEOSTASIS 27 201 3.509e-05 0.0004123
397 NEURON PROJECTION EXTENSION 12 53 3.661e-05 0.0004291
398 SMOOTH MUSCLE TISSUE DEVELOPMENT 7 18 3.705e-05 0.0004332
399 PEPTIDYL SERINE MODIFICATION 22 148 3.892e-05 0.0004539
400 RESPONSE TO ACID CHEMICAL 37 319 3.953e-05 0.0004587
401 REGULATION OF MAP KINASE ACTIVITY 37 319 3.953e-05 0.0004587
402 CALCIUM ION TRANSMEMBRANE TRANSPORT 23 159 4.07e-05 0.0004711
403 NEGATIVE REGULATION OF CELL GROWTH 24 170 4.182e-05 0.0004828
404 VASCULAR SMOOTH MUSCLE CELL DIFFERENTIATION 6 13 4.313e-05 0.0004968
405 DEVELOPMENTAL MATURATION 26 193 4.628e-05 0.0005317
406 NEGATIVE REGULATION OF KINASE ACTIVITY 31 250 4.658e-05 0.0005339
407 REGULATION OF HORMONE SECRETION 32 262 4.767e-05 0.000545
408 MEMBRANE ASSEMBLY 8 25 5.233e-05 0.0005939
409 POSTSYNAPTIC MEMBRANE ORGANIZATION 8 25 5.233e-05 0.0005939
410 LONG TERM SYNAPTIC POTENTIATION 10 39 5.22e-05 0.0005939
411 EAR DEVELOPMENT 26 195 5.523e-05 0.0006253
412 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 21 141 5.621e-05 0.0006348
413 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 28 218 5.721e-05 0.0006446
414 REGULATION OF INTRACELLULAR TRANSPORT 60 621 5.764e-05 0.0006478
415 POSITIVE REGULATION OF DENDRITE DEVELOPMENT 13 64 5.926e-05 0.0006644
416 METAL ION TRANSPORT 57 582 6.062e-05 0.000678
417 EPITHELIAL TO MESENCHYMAL TRANSITION 12 56 6.532e-05 0.0007271
418 OUTFLOW TRACT MORPHOGENESIS 12 56 6.532e-05 0.0007271
419 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 26 197 6.571e-05 0.0007297
420 CELL SUBSTRATE ADHESION 23 164 6.654e-05 0.0007371
421 EPITHELIAL CELL DEVELOPMENT 25 186 6.673e-05 0.0007375
422 DIGESTIVE TRACT MORPHOGENESIS 11 48 6.834e-05 0.0007535
423 REGULATION OF PEPTIDE SECRETION 27 209 6.969e-05 0.0007665
424 NEURON RECOGNITION 9 33 7.315e-05 0.0008027
425 REGULATION OF CYTOPLASMIC TRANSPORT 49 481 7.51e-05 0.0008222
426 OVULATION CYCLE 18 113 7.708e-05 0.0008419
427 POSITIVE REGULATION OF OSSIFICATION 15 84 7.951e-05 0.0008664
428 AXONAL FASCICULATION 7 20 8.153e-05 0.0008864
429 CELL SUBSTRATE JUNCTION ASSEMBLY 10 41 8.288e-05 0.000899
430 CARDIAC CELL DEVELOPMENT 11 49 8.358e-05 0.0009045
431 REGULATION OF EMBRYONIC DEVELOPMENT 18 114 8.67e-05 0.0009352
432 MYELOID CELL DIFFERENTIATION 25 189 8.682e-05 0.0009352
433 PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 9 34 9.444e-05 0.001003
434 RESPONSE TO FLUID SHEAR STRESS 9 34 9.444e-05 0.001003
435 RENAL WATER HOMEOSTASIS 9 34 9.444e-05 0.001003
436 HEART VALVE DEVELOPMENT 9 34 9.444e-05 0.001003
437 STEROID HORMONE MEDIATED SIGNALING PATHWAY 19 125 9.453e-05 0.001003
438 CAMP METABOLIC PROCESS 9 34 9.444e-05 0.001003
439 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 25 190 9.463e-05 0.001003
440 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 29 236 9.499e-05 0.001005
441 REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 8 27 9.69e-05 0.00102
442 REGULATION OF CATENIN IMPORT INTO NUCLEUS 8 27 9.69e-05 0.00102
443 REGULATION OF ADHERENS JUNCTION ORGANIZATION 11 50 0.0001016 0.001068
444 POSITIVE REGULATION OF GLUCOSE TRANSPORT 10 42 0.0001032 0.001079
445 REGULATION OF HEART GROWTH 10 42 0.0001032 0.001079
446 OSTEOBLAST DIFFERENTIATION 19 126 0.0001054 0.001095
447 REGULATION OF CHEMOTAXIS 24 180 0.0001051 0.001095
448 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 19 126 0.0001054 0.001095
449 HORMONE MEDIATED SIGNALING PATHWAY 22 158 0.0001058 0.001096
450 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 18 116 0.0001091 0.001129
451 REGULATION OF ERK1 AND ERK2 CASCADE 29 238 0.0001104 0.001139
452 SPINAL CORD DEVELOPMENT 17 106 0.0001108 0.00114
453 REGULATION OF SODIUM ION TRANSPORT 14 77 0.0001115 0.001142
454 REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 14 77 0.0001115 0.001142
455 CELL COMMUNICATION BY ELECTRICAL COUPLING 6 15 0.0001139 0.001162
456 VENTRICULAR CARDIAC MUSCLE CELL ACTION POTENTIAL 6 15 0.0001139 0.001162
457 IN UTERO EMBRYONIC DEVELOPMENT 35 311 0.000116 0.001182
458 POSITIVE REGULATION OF HEART CONTRACTION 9 35 0.0001207 0.001226
459 REGULATION OF NEUROTRANSMITTER SECRETION 11 51 0.0001229 0.001246
460 CELLULAR MACROMOLECULE LOCALIZATION 102 1234 0.0001237 0.001251
461 AMINOGLYCAN BIOSYNTHETIC PROCESS 17 107 0.0001248 0.001259
462 REGULATION OF SPROUTING ANGIOGENESIS 8 28 0.0001289 0.001298
463 REGULATION OF CELL SHAPE 20 139 0.0001361 0.001368
464 ESTABLISHMENT OF CELL POLARITY 15 88 0.0001374 0.001374
465 REGULATION OF CATION CHANNEL ACTIVITY 15 88 0.0001374 0.001374
466 ION TRANSMEMBRANE TRANSPORT 73 822 0.0001439 0.001437
467 REGULATION OF STRIATED MUSCLE CONTRACTION 14 79 0.0001483 0.001475
468 REGULATION OF SYNAPSE ASSEMBLY 14 79 0.0001483 0.001475
469 NEGATIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 9 36 0.0001528 0.001516
470 MYELOID CELL DEVELOPMENT 10 44 0.0001567 0.001552
471 RESPONSE TO DRUG 44 431 0.0001635 0.001615
472 LEUKOCYTE DIFFERENTIATION 33 292 0.0001659 0.001636
473 CEREBRAL CORTEX RADIALLY ORIENTED CELL MIGRATION 8 29 0.000169 0.001659
474 NEUROBLAST PROLIFERATION 8 29 0.000169 0.001659
475 POSITIVE REGULATION OF CHEMOTAXIS 18 120 0.0001698 0.001664
476 MEGAKARYOCYTE DEVELOPMENT 6 16 0.0001733 0.001687
477 NEGATIVE REGULATION OF STRESS FIBER ASSEMBLY 6 16 0.0001733 0.001687
478 POSITIVE REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 16 0.0001733 0.001687
479 REGULATION OF CALCIUM ION TRANSPORT 26 209 0.0001752 0.001702
480 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 17 110 0.0001764 0.001706
481 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 11 53 0.0001771 0.001706
482 MESONEPHRIC TUBULE MORPHOGENESIS 11 53 0.0001771 0.001706
483 POSITIVE REGULATION OF SYNAPTIC TRANSMISSION 17 110 0.0001764 0.001706
484 SYNAPTIC VESICLE CYCLE 15 90 0.000178 0.001708
485 REGULATION OF CELL MATRIX ADHESION 15 90 0.000178 0.001708
486 ION TRANSPORT 103 1262 0.0001839 0.001761
487 CORONARY VASCULATURE DEVELOPMENT 9 37 0.0001917 0.001831
488 CARDIAC MUSCLE ADAPTATION 5 11 0.000215 0.002042
489 MUSCLE HYPERTROPHY IN RESPONSE TO STRESS 5 11 0.000215 0.002042
490 CARDIAC MUSCLE HYPERTROPHY IN RESPONSE TO STRESS 5 11 0.000215 0.002042
491 AMINOGLYCAN METABOLIC PROCESS 22 166 0.0002188 0.002063
492 MODULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL 8 30 0.000219 0.002063
493 POSITIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 8 30 0.000219 0.002063
494 ESTABLISHMENT OF ENDOTHELIAL BARRIER 8 30 0.000219 0.002063
495 REGULATION OF CELL PROJECTION ASSEMBLY 21 155 0.0002216 0.002083
496 SKELETAL SYSTEM MORPHOGENESIS 25 201 0.0002322 0.002178
497 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 9 38 0.0002385 0.002224
498 REGULATION OF PROTEIN LOCALIZATION 81 950 0.0002376 0.002224
499 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 9 38 0.0002385 0.002224
500 REGIONALIZATION 34 311 0.0002504 0.002331
501 EMBRYONIC DIGESTIVE TRACT MORPHOGENESIS 6 17 0.0002549 0.002344
502 PROTEOGLYCAN METABOLIC PROCESS 14 83 0.0002545 0.002344
503 NEGATIVE REGULATION OF ANOIKIS 6 17 0.0002549 0.002344
504 NEGATIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 6 17 0.0002549 0.002344
505 PARASYMPATHETIC NERVOUS SYSTEM DEVELOPMENT 6 17 0.0002549 0.002344
506 ACTIVATION OF PROTEIN KINASE A ACTIVITY 6 17 0.0002549 0.002344
507 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 22 168 0.00026 0.002386
508 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 56 602 0.0002685 0.00246
509 REGULATION OF ENDOTHELIAL CELL MIGRATION 17 114 0.0002737 0.002502
510 REGULATION OF DENDRITE MORPHOGENESIS 13 74 0.0002769 0.002526
511 SENSORY ORGAN MORPHOGENESIS 28 239 0.0002788 0.002539
512 POSITIVE REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 8 31 0.0002804 0.002548
513 REGULATION OF AXON GUIDANCE 9 39 0.0002943 0.00267
514 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 11 56 0.0002953 0.002673
515 BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 7 24 0.0002972 0.00268
516 REGULATION OF ANOIKIS 7 24 0.0002972 0.00268
517 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 37 352 0.0002989 0.00269
518 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 24 193 0.0003077 0.002764
519 REGULATION OF JNK CASCADE 21 159 0.0003159 0.002832
520 SENSORY PERCEPTION OF PAIN 13 75 0.0003176 0.002842
521 SKELETAL MUSCLE ORGAN DEVELOPMENT 19 137 0.0003209 0.002866
522 ANTERIOR POSTERIOR PATTERN SPECIFICATION 24 194 0.0003325 0.002963
523 MYOFIBRIL ASSEMBLY 10 48 0.0003352 0.002982
524 PRESYNAPTIC PROCESS INVOLVED IN SYNAPTIC TRANSMISSION 17 116 0.0003379 0.003
525 SECRETION BY CELL 47 486 0.0003472 0.003065
526 CYCLIC NUCLEOTIDE METABOLIC PROCESS 11 57 0.0003472 0.003065
527 ENDOTHELIAL CELL MIGRATION 11 57 0.0003472 0.003065
528 NEGATIVE REGULATION OF DENDRITIC SPINE DEVELOPMENT 5 12 0.0003512 0.003071
529 NEGATIVE REGULATION OF CARDIAC MUSCLE TISSUE GROWTH 5 12 0.0003512 0.003071
530 CARTILAGE MORPHOGENESIS 5 12 0.0003512 0.003071
531 CELLULAR RESPONSE TO EPINEPHRINE STIMULUS 5 12 0.0003512 0.003071
532 NEGATIVE REGULATION OF HEART GROWTH 5 12 0.0003512 0.003071
533 SYNAPTIC VESICLE LOCALIZATION 16 106 0.0003562 0.003109
534 REGULATION OF CELL CYCLE 80 949 0.000368 0.003207
535 REGULATION OF PEPTIDE TRANSPORT 29 256 0.0003862 0.003359
536 EPITHELIAL TUBE BRANCHING INVOLVED IN LUNG MORPHOGENESIS 7 25 0.0003925 0.003394
537 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 12 67 0.0003914 0.003394
538 STARTLE RESPONSE 7 25 0.0003925 0.003394
539 SIGNAL RELEASE 22 173 0.000394 0.003402
540 CARDIAC SEPTUM MORPHOGENESIS 10 49 0.0003997 0.003444
541 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 17 118 0.0004146 0.003539
542 ACTOMYOSIN STRUCTURE ORGANIZATION 13 77 0.0004145 0.003539
543 POSITIVE REGULATION OF CATION TRANSMEMBRANE TRANSPORT 15 97 0.0004132 0.003539
544 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 15 97 0.0004132 0.003539
545 REGULATION OF BMP SIGNALING PATHWAY 13 77 0.0004145 0.003539
546 REGULATION OF MEMBRANE DEPOLARIZATION 9 41 0.0004387 0.003718
547 AORTA DEVELOPMENT 9 41 0.0004387 0.003718
548 NEGATIVE REGULATION OF STRESS ACTIVATED MAPK CASCADE 9 41 0.0004387 0.003718
549 NEGATIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 9 41 0.0004387 0.003718
550 MUCOPOLYSACCHARIDE METABOLIC PROCESS 16 108 0.0004415 0.003735
551 REGULATION OF HORMONE LEVELS 46 478 0.0004445 0.003754
552 NEGATIVE REGULATION OF JNK CASCADE 8 33 0.0004454 0.003755
553 REGULATION OF MUSCLE CELL DIFFERENTIATION 20 152 0.0004563 0.003839
554 PEPTIDYL AMINO ACID MODIFICATION 72 841 0.0004643 0.0039
555 OVULATION CYCLE PROCESS 14 88 0.0004738 0.003969
556 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 10 50 0.0004742 0.003969
557 NEGATIVE REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 6 19 0.0005059 0.004211
558 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 6 19 0.0005059 0.004211
559 POSITIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 6 19 0.0005059 0.004211
560 POSITIVE REGULATION OF TRANSMEMBRANE TRANSPORT 18 131 0.0005109 0.004245
561 REGULATION OF PROTEIN COMPLEX ASSEMBLY 38 375 0.000512 0.004246
562 PERIPHERAL NERVOUS SYSTEM DEVELOPMENT 12 69 0.0005176 0.004285
563 ORGANELLE LOCALIZATION 41 415 0.0005272 0.004357
564 BONE MORPHOGENESIS 13 79 0.0005353 0.004416
565 REGULATION OF RESPIRATORY GASEOUS EXCHANGE BY NEUROLOGICAL SYSTEM PROCESS 5 13 0.0005437 0.004454
566 CELL MIGRATION IN HINDBRAIN 5 13 0.0005437 0.004454
567 REGULATION OF CYTOPLASMIC TRANSLATION 5 13 0.0005437 0.004454
568 VENTRICULAR CARDIAC MUSCLE CELL DEVELOPMENT 5 13 0.0005437 0.004454
569 LUNG EPITHELIUM DEVELOPMENT 8 34 0.0005534 0.004502
570 POSITIVE REGULATION OF SODIUM ION TRANSPORT 8 34 0.0005534 0.004502
571 REGULATION OF MESENCHYMAL CELL PROLIFERATION 8 34 0.0005534 0.004502
572 OLIGODENDROCYTE DIFFERENTIATION 11 60 0.0005507 0.004502
573 ARTERY MORPHOGENESIS 10 51 0.0005599 0.004546
574 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 40 404 0.0005872 0.00476
575 REGULATION OF CYCLIC NUCLEOTIDE METABOLIC PROCESS 20 155 0.0005884 0.004762
576 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 18 133 0.0006141 0.00496
577 TRANSMEMBRANE TRANSPORT 89 1098 0.000626 0.005048
578 CELL ACTIVATION 52 568 0.0006343 0.005106
579 PLASMA MEMBRANE ORGANIZATION 24 203 0.0006462 0.005193
580 HIPPO SIGNALING 7 27 0.0006554 0.005249
581 MOTOR NEURON AXON GUIDANCE 7 27 0.0006554 0.005249
582 NEGATIVE REGULATION OF MAPK CASCADE 19 145 0.0006593 0.005271
583 NEGATIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 12 71 0.0006764 0.005398
584 POSITIVE REGULATION OF DENDRITIC SPINE DEVELOPMENT 8 35 0.0006816 0.005431
585 REGULATION OF SMOOTH MUSCLE CELL DIFFERENTIATION 6 20 0.0006878 0.005443
586 CALCIUM ION REGULATED EXOCYTOSIS 13 81 0.0006846 0.005443
587 MEGAKARYOCYTE DIFFERENTIATION 6 20 0.0006878 0.005443
588 LYMPH VESSEL DEVELOPMENT 6 20 0.0006878 0.005443
589 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 24 204 0.0006934 0.005478
590 RESPONSE TO ESTRADIOL 19 146 0.000718 0.005653
591 CELLULAR RESPONSE TO INSULIN STIMULUS 19 146 0.000718 0.005653
592 EXTRACELLULAR STRUCTURE ORGANIZATION 32 304 0.0007238 0.005689
593 CARDIAC VENTRICLE MORPHOGENESIS 11 62 0.0007354 0.005761
594 REGULATION OF STEM CELL DIFFERENTIATION 16 113 0.000735 0.005761
595 RESPONSE TO INSULIN 24 205 0.0007436 0.005815
596 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 9 44 0.0007602 0.005935
597 CYTOSOLIC CALCIUM ION TRANSPORT 10 53 0.0007698 0.00599
598 CELLULAR RESPONSE TO AMINO ACID STIMULUS 10 53 0.0007698 0.00599
599 GLUCOSE HOMEOSTASIS 21 170 0.0007766 0.006022
600 CARBOHYDRATE HOMEOSTASIS 21 170 0.0007766 0.006022
601 RESPONSE TO KETONE 22 182 0.0007912 0.006105
602 RESPONSE TO ESTROGEN 25 218 0.0007902 0.006105
603 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 25 218 0.0007902 0.006105
604 CELL MIGRATION INVOLVED IN HEART DEVELOPMENT 5 14 0.0008058 0.006179
605 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 70 829 0.0008061 0.006179
606 POSITIVE REGULATION OF SPROUTING ANGIOGENESIS 5 14 0.0008058 0.006179
607 REGULATION OF CAMP DEPENDENT PROTEIN KINASE ACTIVITY 5 14 0.0008058 0.006179
608 SECRETION 53 588 0.0008085 0.006187
609 VENTRICULAR SEPTUM MORPHOGENESIS 7 28 0.0008309 0.006311
610 LONG TERM MEMORY 7 28 0.0008309 0.006311
611 NEGATIVE REGULATION OF MUSCLE ORGAN DEVELOPMENT 8 36 0.0008327 0.006311
612 SEMAPHORIN PLEXIN SIGNALING PATHWAY 8 36 0.0008327 0.006311
613 NEURONAL ACTION POTENTIAL 7 28 0.0008309 0.006311
614 POSITIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 8 36 0.0008327 0.006311
615 CELLULAR RESPONSE TO ALCOHOL 16 115 0.0008921 0.006738
616 RESPONSE TO CALCIUM ION 16 115 0.0008921 0.006738
617 TRANSMISSION OF NERVE IMPULSE 10 54 0.0008968 0.006763
618 ENDOCHONDRAL BONE MORPHOGENESIS 9 45 0.0009025 0.006795
619 CELL DIFFERENTIATION IN HINDBRAIN 6 21 0.0009165 0.006878
620 POSITIVE REGULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL 6 21 0.0009165 0.006878
621 REGULATION OF BINDING 30 283 0.0009324 0.006987
622 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 31 296 0.0009449 0.007068
623 ODONTOGENESIS 15 105 0.0009684 0.007233
624 REGULATION OF PROTEIN POLYMERIZATION 21 173 0.0009751 0.007271
625 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 23 197 0.0009848 0.007332
626 CELL CELL JUNCTION ASSEMBLY 12 74 0.0009896 0.007355
627 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 31 297 0.0009985 0.00741
628 REGULATION OF PROTEIN AUTOPHOSPHORYLATION 8 37 0.00101 0.00748
629 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 20 162 0.001032 0.007632
630 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 7 29 0.001042 0.007668
631 POSITIVE REGULATION OF CARTILAGE DEVELOPMENT 7 29 0.001042 0.007668
632 REGULATION OF SYNAPTIC TRANSMISSION GABAERGIC 7 29 0.001042 0.007668
633 ACTIN FILAMENT ORGANIZATION 21 174 0.00105 0.00772
634 PEPTIDYL THREONINE MODIFICATION 9 46 0.001066 0.007821
635 CELLULAR GLUCOSE HOMEOSTASIS 12 75 0.001118 0.00815
636 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL 12 75 0.001118 0.00815
637 REGULATION OF NUCLEOTIDE METABOLIC PROCESS 24 211 0.001116 0.00815
638 MULTI ORGANISM BEHAVIOR 12 75 0.001118 0.00815
639 POSITIVE REGULATION OF CYTOSKELETON ORGANIZATION 21 175 0.00113 0.008231
640 MYELOID LEUKOCYTE DIFFERENTIATION 14 96 0.001151 0.008348
641 NEPHRIC DUCT DEVELOPMENT 5 15 0.001152 0.008348
642 VENOUS BLOOD VESSEL DEVELOPMENT 5 15 0.001152 0.008348
643 REGULATION OF CAMP METABOLIC PROCESS 17 129 0.001162 0.008409
644 VESICLE LOCALIZATION 25 224 0.001168 0.008424
645 REGULATED EXOCYTOSIS 25 224 0.001168 0.008424
646 POSITIVE REGULATION OF HEART RATE 6 22 0.001199 0.008625
647 SOMATIC STEM CELL DIVISION 6 22 0.001199 0.008625
648 CELLULAR RESPONSE TO GLUCAGON STIMULUS 8 38 0.001215 0.008712
649 POSITIVE REGULATION OF ORGAN GROWTH 8 38 0.001215 0.008712
650 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 22 188 0.001217 0.008715
651 POSITIVE REGULATION OF TRANSPORTER ACTIVITY 12 76 0.001259 0.008999
652 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 19 153 0.001269 0.009043
653 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 19 153 0.001269 0.009043
654 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 24 213 0.001272 0.009048
655 GLAND MORPHOGENESIS 14 97 0.001275 0.00906
656 CELL MATRIX ADHESION 16 119 0.001293 0.009156
657 CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 7 30 0.001292 0.009156
658 PLATELET ACTIVATION 18 142 0.00133 0.009403
659 PROTEIN DEPHOSPHORYLATION 22 190 0.001398 0.009869
660 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 14 98 0.001411 0.009946
661 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 16 120 0.001414 0.009953
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 97 629 3.156e-19 2.932e-16
2 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 143 1199 2.456e-17 1.141e-14
3 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 62 328 6.575e-17 2.036e-14
4 CYTOSKELETAL PROTEIN BINDING 108 819 3.143e-16 7.299e-14
5 ENZYME BINDING 182 1737 4.142e-16 7.695e-14
6 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 58 315 2.294e-15 3.551e-13
7 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 47 226 9.417e-15 1.094e-12
8 MACROMOLECULAR COMPLEX BINDING 152 1399 8.242e-15 1.094e-12
9 REGULATORY REGION NUCLEIC ACID BINDING 102 818 8.574e-14 8.85e-12
10 PROTEIN KINASE ACTIVITY 84 640 9.778e-13 9.084e-11
11 KINASE ACTIVITY 101 842 1.267e-12 1.07e-10
12 PROTEIN DOMAIN SPECIFIC BINDING 82 624 1.73e-12 1.339e-10
13 DOUBLE STRANDED DNA BINDING 94 764 1.877e-12 1.341e-10
14 KINASE BINDING 80 606 2.576e-12 1.669e-10
15 SEQUENCE SPECIFIC DNA BINDING 116 1037 2.695e-12 1.669e-10
16 MOLECULAR FUNCTION REGULATOR 138 1353 1.8e-11 1.045e-09
17 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 105 992 7.716e-10 4.217e-08
18 ACTIN BINDING 55 393 8.648e-10 4.463e-08
19 MICROTUBULE BINDING 36 201 1.04e-09 5.085e-08
20 PROTEIN COMPLEX BINDING 100 935 1.155e-09 5.365e-08
21 TRANSLATION REPRESSOR ACTIVITY 11 20 2.252e-09 9.961e-08
22 TUBULIN BINDING 42 273 5.275e-09 2.228e-07
23 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 70 588 5.678e-09 2.293e-07
24 CORE PROMOTER PROXIMAL REGION DNA BINDING 50 371 1.782e-08 6.898e-07
25 PROTEIN TYROSINE KINASE ACTIVITY 31 176 2.231e-08 8.196e-07
26 TRANSCRIPTION FACTOR BINDING 63 524 2.294e-08 8.196e-07
27 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 16 53 2.535e-08 8.723e-07
28 PDZ DOMAIN BINDING 21 90 2.827e-08 9.38e-07
29 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 26 133 3.389e-08 1.049e-06
30 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 36 228 3.279e-08 1.049e-06
31 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 43 303 3.975e-08 1.191e-06
32 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 19 81 1.174e-07 3.408e-06
33 PROTEIN SERINE THREONINE KINASE ACTIVITY 54 445 1.718e-07 4.836e-06
34 ION CHANNEL BINDING 22 111 2.946e-07 8.049e-06
35 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 19 86 3.218e-07 8.541e-06
36 RNA POLYMERASE II TRANSCRIPTION COACTIVATOR ACTIVITY 12 36 4.258e-07 1.099e-05
37 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 16 64 4.583e-07 1.151e-05
38 CHROMATIN BINDING 51 435 1.072e-06 2.621e-05
39 CATION CHANNEL ACTIVITY 39 298 1.375e-06 3.276e-05
40 VOLTAGE GATED ION CHANNEL ACTIVITY 29 190 1.422e-06 3.302e-05
41 CHANNEL REGULATOR ACTIVITY 23 131 1.507e-06 3.415e-05
42 METAL ION TRANSMEMBRANE TRANSPORTER ACTIVITY 49 417 1.628e-06 3.602e-05
43 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 16 70 1.679e-06 3.627e-05
44 TRANSLATION REGULATOR ACTIVITY 11 35 2.514e-06 5.307e-05
45 ACTIVATING TRANSCRIPTION FACTOR BINDING 14 57 2.993e-06 6.178e-05
46 PASSIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 52 464 3.236e-06 6.536e-05
47 BETA CATENIN BINDING 17 84 4.785e-06 9.261e-05
48 GATED CHANNEL ACTIVITY 40 325 4.735e-06 9.261e-05
49 GROWTH FACTOR BINDING 21 123 6.706e-06 0.0001271
50 HISTONE DEACETYLASE BINDING 19 105 7.644e-06 0.000142
51 VOLTAGE GATED SODIUM CHANNEL ACTIVITY 8 20 7.889e-06 0.0001437
52 TRANSCRIPTION COREPRESSOR ACTIVITY 30 221 1.073e-05 0.0001916
53 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 17 90 1.263e-05 0.0002214
54 IDENTICAL PROTEIN BINDING 104 1209 2.175e-05 0.0003742
55 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 11 43 2.267e-05 0.0003828
56 STEROID HORMONE RECEPTOR ACTIVITY 13 59 2.385e-05 0.0003957
57 PHOSPHATIDYLINOSITOL 3 KINASE BINDING 9 30 3.172e-05 0.0005171
58 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 24 168 3.439e-05 0.0005509
59 CALMODULIN BINDING 25 179 3.507e-05 0.0005522
60 TRANSLATION REGULATOR ACTIVITY NUCLEIC ACID BINDING 7 18 3.705e-05 0.0005737
61 CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 20 128 4.186e-05 0.0006375
62 PROTEIN SERINE THREONINE TYROSINE KINASE ACTIVITY 10 39 5.22e-05 0.0007822
63 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 11 48 6.834e-05 0.001008
64 METALLOENDOPEPTIDASE INHIBITOR ACTIVITY 6 14 7.181e-05 0.001042
65 VOLTAGE GATED CATION CHANNEL ACTIVITY 20 134 8.121e-05 0.001161
66 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 17 104 8.688e-05 0.001223
67 HEPARIN BINDING 22 157 9.619e-05 0.001334
68 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 17 105 9.82e-05 0.001342
69 ALPHA ACTININ BINDING 7 21 0.0001162 0.001565
70 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 11 51 0.0001229 0.001632
71 RECEPTOR BINDING 118 1476 0.0001453 0.001901
72 PHOSPHATASE BINDING 22 162 0.0001533 0.001978
73 RIBONUCLEOTIDE BINDING 143 1860 0.0001734 0.002207
74 CAMP BINDING 7 23 0.0002215 0.00278
75 DIVALENT INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 22 167 0.0002386 0.002956
76 SH3 DOMAIN BINDING 17 116 0.0003379 0.00413
77 SODIUM AMINO ACID SYMPORTER ACTIVITY 5 12 0.0003512 0.004177
78 CALCIUM DEPENDENT PROTEIN KINASE ACTIVITY 5 12 0.0003512 0.004177
79 SODIUM CHANNEL REGULATOR ACTIVITY 8 32 0.0003552 0.004177
80 CALCIUM ION BINDING 62 697 0.0004289 0.00498
81 CELL ADHESION MOLECULE BINDING 23 186 0.0004409 0.005056
82 LIPID BINDING 59 657 0.0004616 0.00523
83 PROTEIN DIMERIZATION ACTIVITY 93 1149 0.0004975 0.005568
84 PROTEIN PHOSPHATASE BINDING 17 120 0.0005059 0.005595
85 PROTEIN KINASE A BINDING 9 42 0.0005302 0.005795
86 INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 49 527 0.0006398 0.006911
87 RNA POLYMERASE II TRANSCRIPTION COFACTOR ACTIVITY 14 91 0.0006705 0.00716
88 CYTOKINE BINDING 14 92 0.0007498 0.007827
89 GLYCOSAMINOGLYCAN BINDING 24 205 0.0007436 0.007827
90 SMAD BINDING 12 72 0.0007699 0.007947
91 CYCLIC NUCLEOTIDE BINDING 8 36 0.0008327 0.008409
92 DELAYED RECTIFIER POTASSIUM CHANNEL ACTIVITY 8 36 0.0008327 0.008409
93 SULFUR COMPOUND BINDING 26 234 0.001005 0.009977
94 SODIUM CHANNEL ACTIVITY 8 37 0.00101 0.009977
NumGOOverlapSizeP ValueAdj. P Value
1 SYNAPSE 129 754 8.93e-30 5.215e-27
2 NEURON PART 176 1265 4.738e-29 1.199e-26
3 NEURON PROJECTION 146 942 6.161e-29 1.199e-26
4 CELL PROJECTION 210 1786 9.1e-25 1.329e-22
5 SYNAPSE PART 99 610 3.123e-21 3.648e-19
6 SOMATODENDRITIC COMPARTMENT 99 650 3.225e-19 3.139e-17
7 CELL JUNCTION 143 1151 6.571e-19 5.482e-17
8 DENDRITE 78 451 1.407e-18 1.027e-16
9 POSTSYNAPSE 68 378 2.964e-17 1.923e-15
10 MEMBRANE REGION 130 1134 1.768e-14 1.033e-12
11 AXON 64 418 6.364e-13 3.379e-11
12 EXCITATORY SYNAPSE 40 197 2.084e-12 1.014e-10
13 CELL PROJECTION PART 107 946 1.04e-11 4.673e-10
14 PLASMA MEMBRANE REGION 105 929 1.723e-11 7.188e-10
15 ACTIN CYTOSKELETON 62 444 7.924e-11 3.085e-09
16 CELL LEADING EDGE 53 350 9.601e-11 3.504e-09
17 CATION CHANNEL COMPLEX 33 167 3.728e-10 1.209e-08
18 CELL BODY 65 494 3.533e-10 1.209e-08
19 SYNAPTIC MEMBRANE 43 261 3.972e-10 1.221e-08
20 CYTOSKELETON 174 1967 3.387e-09 9.891e-08
21 PLASMA MEMBRANE PROTEIN COMPLEX 63 510 8.142e-09 2.264e-07
22 PRESYNAPSE 42 283 1.549e-08 4.111e-07
23 NEURON SPINE 25 121 1.948e-08 4.947e-07
24 SITE OF POLARIZED GROWTH 28 149 2.504e-08 6.094e-07
25 SARCOLEMMA 25 125 3.859e-08 8.667e-07
26 AXON PART 35 219 3.714e-08 8.667e-07
27 TRANSPORTER COMPLEX 44 321 7.764e-08 1.679e-06
28 I BAND 24 121 8.483e-08 1.769e-06
29 CELL SURFACE 80 757 9.526e-08 1.918e-06
30 CONTRACTILE FIBER 32 211 4.781e-07 9.306e-06
31 POSTSYNAPTIC MEMBRANE 31 205 7.663e-07 1.444e-05
32 MEMBRANE MICRODOMAIN 38 288 1.531e-06 2.795e-05
33 PERIKARYON 20 108 3.067e-06 5.427e-05
34 T TUBULE 12 45 6.046e-06 0.0001038
35 NEURONAL POSTSYNAPTIC DENSITY 13 53 6.84e-06 0.000111
36 CELL CORTEX 32 238 6.76e-06 0.000111
37 CELL CELL JUNCTION 44 383 9.752e-06 0.0001539
38 CELL CELL CONTACT ZONE 14 64 1.276e-05 0.0001962
39 LAMELLIPODIUM 25 172 1.764e-05 0.0002641
40 CYTOPLASMIC REGION 35 287 2.221e-05 0.0003243
41 ANCHORING JUNCTION 51 489 2.917e-05 0.0004155
42 BASOLATERAL PLASMA MEMBRANE 28 211 3.17e-05 0.0004408
43 POTASSIUM CHANNEL COMPLEX 16 90 4.915e-05 0.0006675
44 PRESYNAPTIC MEMBRANE 12 55 5.412e-05 0.0007184
45 RECEPTOR COMPLEX 37 327 6.7e-05 0.0008695
46 VOLTAGE GATED SODIUM CHANNEL COMPLEX 6 14 7.181e-05 0.0009116
47 AXONAL GROWTH CONE 7 20 8.153e-05 0.001013
48 FILOPODIUM 16 94 8.465e-05 0.00103
49 CYTOSKELETAL PART 116 1436 0.0001091 0.001301
50 INTERCALATED DISC 11 51 0.0001229 0.001408
51 INTRINSIC COMPONENT OF PLASMA MEMBRANE 130 1649 0.0001214 0.001408
52 CELL CORTEX PART 18 119 0.0001524 0.001712
53 ACTOMYOSIN 12 62 0.0001837 0.002025
54 NEUROMUSCULAR JUNCTION 11 54 0.0002109 0.002281
55 CELL SUBSTRATE JUNCTION 41 398 0.0002227 0.002365
56 LEADING EDGE MEMBRANE 19 134 0.0002404 0.002507
57 SODIUM CHANNEL COMPLEX 6 17 0.0002549 0.002611
58 VOLTAGE GATED CALCIUM CHANNEL COMPLEX 9 40 0.0003606 0.003631
59 PLASMA MEMBRANE RAFT 14 86 0.000372 0.003682
60 COATED PIT 12 67 0.0003914 0.00381
61 MAIN AXON 11 58 0.0004065 0.003891
62 NEURON PROJECTION TERMINUS 18 129 0.000423 0.003985
63 BASAL PLASMA MEMBRANE 8 33 0.0004454 0.004129
64 A BAND 8 34 0.0005534 0.00503
65 BASAL PART OF CELL 10 51 0.0005599 0.00503
66 PROTEIN KINASE COMPLEX 14 90 0.0005985 0.005216
67 ACTIN FILAMENT 12 70 0.0005925 0.005216
68 MICROTUBULE 40 405 0.0006164 0.005294
69 GOLGI APPARATUS 112 1445 0.0006793 0.00575
70 CALCIUM CHANNEL COMPLEX 11 62 0.0007354 0.006135
71 MEMBRANE PROTEIN COMPLEX 83 1020 0.0008447 0.006948
72 MICROTUBULE END 6 22 0.001199 0.009728

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 51 295 1.428e-12 7.425e-11
2 Focal_adhesion_hsa04510 39 199 1.241e-11 3.227e-10
3 Rap1_signaling_pathway_hsa04015 37 206 5.625e-10 8.318e-09
4 Regulation_of_actin_cytoskeleton_hsa04810 37 208 7.452e-10 8.318e-09
5 Apelin_signaling_pathway_hsa04371 29 137 7.998e-10 8.318e-09
6 cGMP_PKG_signaling_pathway_hsa04022 31 163 3.351e-09 2.904e-08
7 Ras_signaling_pathway_hsa04014 37 232 1.614e-08 1.199e-07
8 PI3K_Akt_signaling_pathway_hsa04151 48 352 2.364e-08 1.537e-07
9 FoxO_signaling_pathway_hsa04068 25 132 1.184e-07 6.84e-07
10 Hippo_signaling_pathway_hsa04390 27 154 1.96e-07 1.019e-06
11 ErbB_signaling_pathway_hsa04012 19 85 2.648e-07 1.252e-06
12 cAMP_signaling_pathway_hsa04024 31 198 3.521e-07 1.526e-06
13 Calcium_signaling_pathway_hsa04020 29 182 5.729e-07 2.292e-06
14 Phospholipase_D_signaling_pathway_hsa04072 25 146 8.694e-07 3.014e-06
15 Wnt_signaling_pathway_hsa04310 25 146 8.694e-07 3.014e-06
16 Gap_junction_hsa04540 18 88 2.156e-06 7.007e-06
17 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 22 139 1.433e-05 4.383e-05
18 Autophagy_animal_hsa04140 20 128 4.186e-05 0.0001209
19 mTOR_signaling_pathway_hsa04150 21 151 0.000153 0.000414
20 Phosphatidylinositol_signaling_system_hsa04070 16 99 0.0001592 0.000414
21 Adherens_junction_hsa04520 13 72 0.0002087 0.0005168
22 HIF_1_signaling_pathway_hsa04066 15 100 0.000576 0.001361
23 Jak_STAT_signaling_pathway_hsa04630 20 162 0.001032 0.002257
24 Hippo_signaling_pathway_multiple_species_hsa04392 7 29 0.001042 0.002257
25 Sphingolipid_signaling_pathway_hsa04071 16 118 0.001181 0.002456
26 Tight_junction_hsa04530 20 170 0.001863 0.003725
27 AMPK_signaling_pathway_hsa04152 15 121 0.004004 0.007579
28 Cell_adhesion_molecules_.CAMs._hsa04514 17 145 0.004081 0.007579
29 Hedgehog_signaling_pathway_hsa04340 8 47 0.004947 0.008744
30 Oocyte_meiosis_hsa04114 15 124 0.005044 0.008744
31 VEGF_signaling_pathway_hsa04370 9 59 0.006237 0.01046
32 Cellular_senescence_hsa04218 17 160 0.01074 0.01746
33 ECM_receptor_interaction_hsa04512 10 82 0.01892 0.02982
34 TGF_beta_signaling_pathway_hsa04350 10 84 0.02206 0.03373
35 p53_signaling_pathway_hsa04115 8 68 0.04066 0.06041
36 Apoptosis_hsa04210 12 138 0.1001 0.1446
37 NF_kappa_B_signaling_pathway_hsa04064 8 95 0.1798 0.2527
38 Endocytosis_hsa04144 17 244 0.2404 0.329
39 TNF_signaling_pathway_hsa04668 8 108 0.2817 0.3755
40 Apoptosis_multiple_species_hsa04215 3 33 0.2947 0.383
41 Mitophagy_animal_hsa04137 5 65 0.3183 0.4037
42 Ferroptosis_hsa04216 3 40 0.4063 0.5031
43 Neuroactive_ligand_receptor_interaction_hsa04080 17 278 0.4324 0.5229
44 ABC_transporters_hsa02010 3 45 0.483 0.5708
45 Notch_signaling_pathway_hsa04330 3 48 0.5266 0.6085
46 Cytokine_cytokine_receptor_interaction_hsa04060 15 270 0.5925 0.6698
47 Phagosome_hsa04145 8 152 0.652 0.7214
48 Necroptosis_hsa04217 8 164 0.7327 0.7937
49 Cell_cycle_hsa04110 5 124 0.8473 0.8801
50 Peroxisome_hsa04146 3 83 0.8632 0.8801
51 Lysosome_hsa04142 3 123 0.9753 0.9753

Quest ID: 23c87d8de2e40a0ffcc99dd47318e516