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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-197-3p ABCC3 -1.3 0 2.16 0 miRNAWalker2 validate -0.28 2.0E-5 NA
2 hsa-miR-576-5p ABCD3 1.03 0 -0.14 0.33401 mirMAP -0.11 0.00054 NA
3 hsa-miR-26a-2-3p ABHD2 0.26 0.30565 -0.74 0.00059 mirMAP -0.21 2.0E-5 NA
4 hsa-miR-576-5p ABHD2 1.03 0 -0.74 0.00059 mirMAP -0.13 0.00405 NA
5 hsa-miR-576-5p ABI3BP 1.03 0 -3.27 0 PITA -0.34 5.0E-5 NA
6 hsa-miR-576-5p ACADSB 1.03 0 -0.71 0.001 mirMAP -0.2 3.0E-5 NA
7 hsa-miR-576-5p ACOX2 1.03 0 -0.57 0.05834 MirTarget -0.35 0 NA
8 hsa-miR-576-5p ACSL4 1.03 0 -1.28 0 mirMAP -0.11 0.01887 NA
9 hsa-miR-576-5p ACTR8 1.03 0 -0.03 0.69902 MirTarget -0.1 0 NA
10 hsa-miR-197-3p ACVR1B -1.3 0 0.53 0.00341 miRNAWalker2 validate; MirTarget -0.14 1.0E-5 NA
11 hsa-miR-26a-2-3p ADAM28 0.26 0.30565 2.16 0 mirMAP -0.22 0.00321 NA
12 hsa-miR-576-5p ADCYAP1 1.03 0 -1.16 0.01936 PITA; mirMAP -0.25 0.01963 NA
13 hsa-miR-576-5p AFF2 1.03 0 -2.23 0 PITA; mirMAP -0.4 5.0E-5 NA
14 hsa-miR-576-5p AFF4 1.03 0 -0.15 0.22477 mirMAP -0.12 2.0E-5 NA
15 hsa-miR-26a-2-3p AGPS 0.26 0.30565 0 0.99631 mirMAP -0.13 0 NA
16 hsa-miR-197-3p AGR2 -1.3 0 1.73 0.00012 miRNAWalker2 validate -0.32 0.00011 NA
17 hsa-miR-576-5p AKAP2 1.03 0 -2.97 0 mirMAP -0.21 0.0007 NA
18 hsa-miR-576-5p ALAD 1.03 0 -0.42 0.00031 mirMAP -0.13 0 NA
19 hsa-miR-576-5p ALDH6A1 1.03 0 -0.33 0.09417 mirMAP -0.19 1.0E-5 NA
20 hsa-miR-576-5p AMOT 1.03 0 -0.3 0.45043 mirMAP -0.3 0.00043 NA
21 hsa-miR-576-5p ANKRD46 1.03 0 -0.38 0.01504 MirTarget; PITA -0.13 9.0E-5 NA
22 hsa-miR-576-5p ANKRD50 1.03 0 -0.3 0.07201 MirTarget; mirMAP -0.15 2.0E-5 NA
23 hsa-miR-576-5p ANO6 1.03 0 -1.11 0 MirTarget; mirMAP -0.12 0.00021 NA
24 hsa-miR-576-5p ANTXR1 1.03 0 -0.82 0.00129 MirTarget; PITA -0.36 0 NA
25 hsa-miR-576-5p ANTXR2 1.03 0 -0.2 0.28312 mirMAP -0.18 1.0E-5 NA
26 hsa-miR-26a-2-3p AP2B1 0.26 0.30565 -0.07 0.54488 mirMAP -0.11 8.0E-5 NA
27 hsa-miR-576-5p APH1B 1.03 0 -1.16 0 MirTarget -0.12 0.00274 NA
28 hsa-miR-576-5p APPL1 1.03 0 -0.32 0.00241 MirTarget -0.13 0 NA
29 hsa-miR-576-5p AR 1.03 0 -1.82 6.0E-5 mirMAP -0.48 0 NA
30 hsa-miR-576-5p ARHGAP18 1.03 0 -1.27 0 MirTarget -0.18 0 NA
31 hsa-miR-576-5p ARHGAP28 1.03 0 -1.3 0 mirMAP -0.21 0.00036 NA
32 hsa-miR-576-5p ARHGAP31 1.03 0 -2.49 0 mirMAP -0.36 0 NA
33 hsa-miR-576-5p ARHGAP5 1.03 0 -0.06 0.65654 MirTarget; PITA -0.13 2.0E-5 NA
34 hsa-miR-576-5p ARHGEF12 1.03 0 -0.37 0.00513 mirMAP -0.16 0 NA
35 hsa-miR-576-5p ARID5B 1.03 0 -0.45 0.00256 PITA; mirMAP -0.2 0 NA
36 hsa-miR-26a-2-3p ARL5B 0.26 0.30565 0.2 0.27406 mirMAP -0.2 0 NA
37 hsa-miR-576-5p ARMC3 1.03 0 -1.33 0.02276 MirTarget -0.29 0.02139 NA
38 hsa-miR-576-5p ARNT2 1.03 0 -1.46 3.0E-5 mirMAP -0.37 0 NA
39 hsa-miR-26a-2-3p ASXL2 0.26 0.30565 -0.3 0.12837 mirMAP -0.24 0 NA
40 hsa-miR-26a-2-3p ATE1 0.26 0.30565 -0.47 0.01177 mirMAP -0.3 0 NA
41 hsa-miR-26a-2-3p ATL3 0.26 0.30565 0.11 0.46975 mirMAP -0.16 0 NA
42 hsa-miR-576-5p ATP10A 1.03 0 -1.58 0 mirMAP -0.34 0 NA
43 hsa-miR-197-3p ATP11A -1.3 0 -0.3 0.27412 miRNAWalker2 validate -0.24 0 NA
44 hsa-miR-576-5p ATP7A 1.03 0 -0.09 0.53505 mirMAP -0.12 6.0E-5 NA
45 hsa-miR-576-5p ATRX 1.03 0 -0.09 0.47606 mirMAP -0.14 0 NA
46 hsa-miR-576-5p AZI2 1.03 0 -0.58 0 mirMAP -0.11 0 NA
47 hsa-miR-576-5p BAALC 1.03 0 -1.84 0.00013 mirMAP -0.31 0.0028 NA
48 hsa-miR-576-5p BACE1 1.03 0 -0.8 0 mirMAP -0.23 0 NA
49 hsa-miR-26a-2-3p BARD1 0.26 0.30565 0.84 0.00035 mirMAP -0.16 0.00208 NA
50 hsa-miR-26a-2-3p BBX 0.26 0.30565 -0.3 0.02503 MirTarget; mirMAP -0.1 0.00036 NA
51 hsa-miR-576-5p BCAT1 1.03 0 -0.21 0.54581 MirTarget -0.18 0.02244 NA
52 hsa-miR-576-5p BMP3 1.03 0 -1.37 0.01092 mirMAP -0.78 0 NA
53 hsa-miR-576-5p BMP5 1.03 0 -1.82 0.00019 mirMAP -0.4 0.00015 NA
54 hsa-miR-26a-2-3p BMPR2 0.26 0.30565 -1.25 0 mirMAP -0.1 0.00041 NA
55 hsa-miR-576-5p BNC2 1.03 0 -1.12 1.0E-5 PITA; mirMAP -0.2 0.00033 NA
56 hsa-miR-576-5p C10orf107 1.03 0 -2.89 0 miRNATAP -0.61 0 NA
57 hsa-miR-197-3p C11orf86 -1.3 0 3.99 0 mirMAP -0.41 0.00115 NA
58 hsa-miR-576-5p C1QTNF7 1.03 0 -3.31 0 mirMAP -0.76 0 NA
59 hsa-miR-576-5p C1orf141 1.03 0 -2.71 0 mirMAP -0.26 0.03576 NA
60 hsa-miR-576-5p C21orf91 1.03 0 -0.41 0.01652 PITA -0.1 0.0046 NA
61 hsa-miR-576-5p C3orf58 1.03 0 -1 0 mirMAP -0.13 0.00078 NA
62 hsa-miR-576-5p C3orf70 1.03 0 -1.59 0 mirMAP -0.22 0.00024 NA
63 hsa-miR-576-5p CA5B 1.03 0 -0.85 0 mirMAP -0.15 0 NA
64 hsa-miR-576-5p CA8 1.03 0 -1.29 0.01871 PITA -0.27 0.02369 NA
65 hsa-miR-576-5p CACNA2D1 1.03 0 -1.27 0.00469 mirMAP -0.27 0.00614 NA
66 hsa-miR-26a-2-3p CADM2 0.26 0.30565 -0.95 0.08706 MirTarget -0.28 0.02523 NA
67 hsa-miR-576-5p CALM1 1.03 0 -0.79 0 mirMAP -0.14 0 NA
68 hsa-miR-197-3p CAMK2D -1.3 0 -0.09 0.59253 miRNATAP -0.12 9.0E-5 NA
69 hsa-miR-576-5p CANX 1.03 0 0.19 0.13353 MirTarget -0.15 0 NA
70 hsa-miR-26a-2-3p CASC4 0.26 0.30565 -0.1 0.37799 mirMAP -0.18 0 NA
71 hsa-miR-576-5p CCDC152 1.03 0 -1.45 0 mirMAP -0.12 0.02581 NA
72 hsa-miR-576-5p CCDC68 1.03 0 -1.37 1.0E-5 mirMAP -0.14 0.03537 NA
73 hsa-miR-576-5p CCDC85A 1.03 0 -3.11 0 PITA -0.37 0 NA
74 hsa-miR-197-3p CCNG1 -1.3 0 -0.38 0.02147 miRNAWalker2 validate -0.12 6.0E-5 NA
75 hsa-miR-576-5p CD47 1.03 0 -0.76 2.0E-5 mirMAP -0.13 0.00075 NA
76 hsa-miR-576-5p CD93 1.03 0 -2.41 0 mirMAP -0.23 1.0E-5 NA
77 hsa-miR-576-5p CDC14A 1.03 0 -1.19 0 mirMAP -0.13 0.00347 NA
78 hsa-miR-576-5p CDC42EP3 1.03 0 -0.09 0.67344 mirMAP -0.2 2.0E-5 NA
79 hsa-miR-576-5p CDC42SE2 1.03 0 0.14 0.24342 mirMAP -0.14 0 NA
80 hsa-miR-576-5p CDH11 1.03 0 -0.31 0.2443 PITA; mirMAP; miRNATAP -0.37 0 NA
81 hsa-miR-576-5p CDH6 1.03 0 -1.47 0 PITA; mirMAP -0.29 1.0E-5 NA
82 hsa-miR-576-5p CELF2 1.03 0 -1.51 0 mirMAP -0.28 0 NA
83 hsa-miR-576-5p CETN3 1.03 0 0.14 0.30115 MirTarget; PITA -0.15 0 NA
84 hsa-miR-576-5p CHD9 1.03 0 -0.37 0.00502 MirTarget; PITA; mirMAP -0.16 0 NA
85 hsa-miR-576-5p CHIC1 1.03 0 -0.41 0.01467 mirMAP -0.13 0.00051 NA
86 hsa-miR-576-5p CHURC1 1.03 0 -0.58 0 mirMAP; miRNATAP -0.17 0 NA
87 hsa-miR-26a-2-3p CLOCK 0.26 0.30565 0.04 0.82828 mirMAP -0.21 0 NA
88 hsa-miR-576-5p CLSTN2 1.03 0 -1.51 0.0001 MirTarget -0.34 6.0E-5 NA
89 hsa-miR-576-5p CLUAP1 1.03 0 -0.19 0.12194 mirMAP -0.13 0 NA
90 hsa-miR-576-5p CMYA5 1.03 0 0.09 0.75734 MirTarget -0.13 0.04159 NA
91 hsa-miR-576-5p CNIH4 1.03 0 0.27 0.07813 mirMAP -0.11 0.00064 NA
92 hsa-miR-576-5p CNOT6L 1.03 0 -0.36 0.00099 mirMAP -0.12 0 NA
93 hsa-miR-576-5p CNR1 1.03 0 -2.51 0 mirMAP -0.37 0.00011 NA
94 hsa-miR-576-5p COBLL1 1.03 0 -0.94 0 MirTarget; mirMAP -0.15 0.00041 NA
95 hsa-miR-576-5p COL4A4 1.03 0 -1.76 0 PITA -0.33 3.0E-5 NA
96 hsa-miR-576-5p COL6A6 1.03 0 -4.05 0 mirMAP -0.42 0.00019 NA
97 hsa-miR-576-5p COL8A1 1.03 0 -0.63 0.04654 mirMAP -0.35 0 NA
98 hsa-miR-197-3p CPEB2 -1.3 0 -0.46 0.00519 miRNATAP -0.14 0 NA
99 hsa-miR-576-5p CPNE3 1.03 0 -0.22 0.10376 mirMAP -0.14 0 NA
100 hsa-miR-576-5p CREB5 1.03 0 -0.94 0.00202 PITA; mirMAP -0.19 0.00365 NA
101 hsa-miR-576-5p CRLS1 1.03 0 -0.6 0.00033 mirMAP -0.15 4.0E-5 NA
102 hsa-miR-576-5p CSNK1A1 1.03 0 0.1 0.35405 mirMAP -0.12 0 NA
103 hsa-miR-26a-2-3p CSRNP3 0.26 0.30565 -0.53 0.17748 mirMAP -0.34 0.00012 NA
104 hsa-miR-26a-2-3p CTAGE1 0.26 0.30565 0.07 0.78056 mirMAP -0.26 1.0E-5 NA
105 hsa-miR-26a-2-3p CTNND1 0.26 0.30565 -0.12 0.34444 mirMAP -0.1 0.00018 NA
106 hsa-miR-26a-2-3p CTNND2 0.26 0.30565 -3.29 3.0E-5 MirTarget -0.49 0.00607 NA
107 hsa-miR-576-5p CTSS 1.03 0 -1.07 0 mirMAP -0.1 0.02565 NA
108 hsa-miR-576-5p CXADR 1.03 0 -0.22 0.35808 mirMAP -0.22 1.0E-5 NA
109 hsa-miR-576-5p CYP19A1 1.03 0 0.16 0.63336 mirMAP -0.16 0.03132 NA
110 hsa-miR-197-3p CYP27C1 -1.3 0 2.55 0 miRNATAP -0.19 0.04258 NA
111 hsa-miR-576-5p CYYR1 1.03 0 -2.47 0 MirTarget; mirMAP -0.28 0 NA
112 hsa-miR-576-5p DAAM1 1.03 0 -0.44 0.00894 mirMAP -0.14 0.00011 NA
113 hsa-miR-576-5p DBT 1.03 0 -0.14 0.26763 MirTarget -0.11 6.0E-5 NA
114 hsa-miR-26a-2-3p DCUN1D1 0.26 0.30565 0.14 0.30132 mirMAP -0.14 1.0E-5 NA
115 hsa-miR-576-5p DIO1 1.03 0 -0.16 0.75955 mirMAP -0.26 0.02293 NA
116 hsa-miR-576-5p DKK2 1.03 0 -2.46 0 mirMAP -0.3 2.0E-5 NA
117 hsa-miR-576-5p DLG2 1.03 0 -0.4 0.15229 PITA; mirMAP -0.22 0.00031 NA
118 hsa-miR-576-5p DMXL1 1.03 0 -0.65 0 PITA -0.14 0 NA
119 hsa-miR-197-3p DNAH5 -1.3 0 0.22 0.54543 MirTarget -0.19 0.00334 NA
120 hsa-miR-576-5p DNAH5 1.03 0 0.22 0.54543 MirTarget -0.26 0.00085 NA
121 hsa-miR-26a-2-3p DNAJB14 0.26 0.30565 -0.4 0.00192 mirMAP -0.15 0 NA
122 hsa-miR-576-5p DNM3 1.03 0 -1.53 0 mirMAP -0.25 6.0E-5 NA
123 hsa-miR-576-5p DOCK11 1.03 0 -1.72 0 PITA -0.13 0.01585 NA
124 hsa-miR-26a-2-3p DOK6 0.26 0.30565 -1.82 0 mirMAP -0.17 0.02074 NA
125 hsa-miR-576-5p DPP10 1.03 0 0.28 0.69026 PITA -0.32 0.03588 NA
126 hsa-miR-576-5p DRAM1 1.03 0 -1.48 0 mirMAP -0.38 0 NA
127 hsa-miR-576-5p DTWD2 1.03 0 -0.36 0.01621 MirTarget -0.2 0 NA
128 hsa-miR-576-5p EDA2R 1.03 0 -1.12 0.00506 PITA; mirMAP -0.52 0 NA
129 hsa-miR-26a-2-3p EDEM3 0.26 0.30565 0.53 7.0E-5 mirMAP -0.18 0 NA
130 hsa-miR-576-5p EDNRA 1.03 0 -1.13 0 mirMAP -0.33 0 NA
131 hsa-miR-576-5p EEA1 1.03 0 -0.47 0.00057 MirTarget; PITA; mirMAP -0.14 0 NA
132 hsa-miR-576-5p EFR3A 1.03 0 0.12 0.37998 MirTarget -0.11 0.00016 NA
133 hsa-miR-26a-2-3p EIF2AK2 0.26 0.30565 0.62 9.0E-5 mirMAP -0.11 0.00199 NA
134 hsa-miR-576-5p EIF4EBP2 1.03 0 -0.49 1.0E-5 mirMAP -0.12 0 NA
135 hsa-miR-26a-2-3p EIF5A2 0.26 0.30565 -0.01 0.97137 mirMAP -0.17 0.0003 NA
136 hsa-miR-576-5p ELL2 1.03 0 0.08 0.62125 PITA -0.14 0.00013 NA
137 hsa-miR-576-5p EMCN 1.03 0 -3.04 0 mirMAP -0.35 0 NA
138 hsa-miR-576-5p EMP2 1.03 0 -2.84 0 mirMAP -0.4 0 NA
139 hsa-miR-576-5p ENAM 1.03 0 -1.28 0.03627 mirMAP -0.61 0 NA
140 hsa-miR-576-5p ENTPD1 1.03 0 -0.52 8.0E-5 mirMAP -0.11 0.00015 NA
141 hsa-miR-26a-2-3p ENTPD7 0.26 0.30565 0.96 0 MirTarget -0.15 0.00014 NA
142 hsa-miR-576-5p EPHA4 1.03 0 0.15 0.63926 PITA; miRNATAP -0.44 0 NA
143 hsa-miR-576-5p ERBB4 1.03 0 -3.26 0 PITA -0.67 0 NA
144 hsa-miR-34b-3p ESPL1 -1.69 0.00178 3.15 0 MirTarget -0.18 0 NA
145 hsa-miR-576-5p ETS1 1.03 0 -1.33 0 mirMAP -0.13 0.00314 NA
146 hsa-miR-576-5p EVI2A 1.03 0 -0.97 9.0E-5 mirMAP -0.17 0.00164 NA
147 hsa-miR-26a-2-3p FAM102B 0.26 0.30565 -0.59 0.00326 mirMAP -0.13 0.00526 NA
148 hsa-miR-576-5p FAM117A 1.03 0 -0.25 0.12643 miRNATAP -0.13 0.00031 NA
149 hsa-miR-576-5p FAM129A 1.03 0 -0.7 0.00617 mirMAP -0.27 0 NA
150 hsa-miR-576-5p FAM13A 1.03 0 0.34 0.10676 mirMAP -0.13 0.00631 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEVELOPMENT 82 1426 2.902e-09 1.35e-05
2 REGULATION OF CELL DIFFERENTIATION 82 1492 2.234e-08 3.464e-05
3 REGULATION OF CELLULAR COMPONENT MOVEMENT 52 771 2.124e-08 3.464e-05
4 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 88 1672 4.677e-08 5.44e-05
5 BIOLOGICAL ADHESION 62 1032 6.483e-08 6.034e-05
6 TISSUE DEVELOPMENT 81 1518 9.787e-08 7.59e-05
7 VASCULATURE DEVELOPMENT 36 469 1.592e-07 0.0001058
8 SKELETAL SYSTEM DEVELOPMENT 35 455 2.254e-07 0.000117
9 MUSCLE SYSTEM PROCESS 26 282 2.767e-07 0.000117
10 CARDIOVASCULAR SYSTEM DEVELOPMENT 50 788 2.635e-07 0.000117
11 CIRCULATORY SYSTEM DEVELOPMENT 50 788 2.635e-07 0.000117
12 MUSCLE CONTRACTION 23 233 4.055e-07 0.0001572
13 CIRCULATORY SYSTEM PROCESS 30 366 4.402e-07 0.0001575
14 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 63 1142 9.996e-07 0.0003322
15 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 44 689 1.192e-06 0.0003697
16 CARDIAC MUSCLE CELL CONTRACTION 8 29 1.29e-06 0.0003752
17 REGULATION OF ANATOMICAL STRUCTURE SIZE 34 472 1.5e-06 0.0004105
18 NEUROGENESIS 72 1402 2.231e-06 0.0005766
19 CELLULAR COMPONENT MORPHOGENESIS 52 900 2.521e-06 0.0006174
20 REGULATION OF SYSTEM PROCESS 35 507 2.755e-06 0.000641
21 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 71 1395 3.621e-06 0.0008023
22 REGULATION OF ION TRANSPORT 38 592 5.74e-06 0.001195
23 POSITIVE REGULATION OF OSSIFICATION 12 84 5.909e-06 0.001195
24 REGULATION OF ENDOTHELIAL CELL MIGRATION 14 114 6.232e-06 0.001199
25 HEART PROCESS 12 85 6.7e-06 0.001199
26 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 23 274 6.554e-06 0.001199
27 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 55 1008 7.011e-06 0.001208
28 POSITIVE REGULATION OF LOCOMOTION 30 420 7.319e-06 0.001216
29 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 17 166 8.005e-06 0.001284
30 CARDIAC MUSCLE CELL ACTION POTENTIAL 8 37 9.438e-06 0.001464
31 POSITIVE REGULATION OF CELL DIFFERENTIATION 47 823 1.056e-05 0.001585
32 CELL PROJECTION ORGANIZATION 50 902 1.226e-05 0.001783
33 REGULATION OF AXON GUIDANCE 8 39 1.428e-05 0.002014
34 CELLULAR RESPONSE TO HORMONE STIMULUS 35 552 1.74e-05 0.002314
35 CONNECTIVE TISSUE DEVELOPMENT 18 194 1.717e-05 0.002314
36 ACTION POTENTIAL 12 94 1.915e-05 0.002463
37 REGULATION OF GTPASE ACTIVITY 40 673 1.983e-05 0.002463
38 REGULATION OF OSSIFICATION 17 178 2.012e-05 0.002463
39 REGULATION OF BLOOD CIRCULATION 23 295 2.167e-05 0.002585
40 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 10 67 2.383e-05 0.002616
41 RESPONSE TO ENDOGENOUS STIMULUS 70 1450 2.474e-05 0.002616
42 REGULATION OF HOMEOSTATIC PROCESS 30 447 2.42e-05 0.002616
43 REGULATION OF CHEMOTAXIS 17 180 2.326e-05 0.002616
44 MUSCLE CELL DIFFERENTIATION 20 237 2.401e-05 0.002616
45 CARTILAGE DEVELOPMENT 15 147 2.823e-05 0.002919
46 BLOOD VESSEL MORPHOGENESIS 26 364 2.953e-05 0.002987
47 POSITIVE REGULATION OF GENE EXPRESSION 80 1733 3.028e-05 0.002998
48 REGULATION OF EPITHELIAL CELL MIGRATION 16 166 3.131e-05 0.003025
49 NEURON PROJECTION DEVELOPMENT 34 545 3.186e-05 0.003025
50 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 10 70 3.524e-05 0.003279
51 REGULATION OF RESPONSE TO WOUNDING 28 413 3.759e-05 0.00343
52 RESPONSE TO HORMONE 48 893 4e-05 0.003579
53 TUBE DEVELOPMENT 34 552 4.114e-05 0.003612
54 CELL PROLIFERATION 39 672 4.25e-05 0.003663
55 PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 7 34 4.833e-05 0.003879
56 TAXIS 30 464 4.835e-05 0.003879
57 REGULATION OF MESENCHYMAL CELL PROLIFERATION 7 34 4.833e-05 0.003879
58 NEURON DIFFERENTIATION 47 874 4.766e-05 0.003879
59 FOREBRAIN DEVELOPMENT 25 357 5.773e-05 0.004468
60 NEURON PROJECTION MORPHOGENESIS 27 402 6.043e-05 0.004468
61 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 62 1275 6.05e-05 0.004468
62 MULTI MULTICELLULAR ORGANISM PROCESS 18 213 5.95e-05 0.004468
63 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 9 60 5.837e-05 0.004468
64 ACTIN FILAMENT BASED PROCESS 29 450 6.822e-05 0.00496
65 RESPONSE TO STEROID HORMONE 31 497 7.091e-05 0.005076
66 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 31 498 7.357e-05 0.005187
67 GROWTH 27 410 8.419e-05 0.005847
68 REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 8 50 9.391e-05 0.006242
69 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 25 368 9.378e-05 0.006242
70 NEGATIVE REGULATION OF ION TRANSPORT 13 127 9.222e-05 0.006242
71 REGULATION OF HEART CONTRACTION 18 221 9.569e-05 0.006271
72 NEGATIVE REGULATION OF PLATELET ACTIVATION 5 17 9.804e-05 0.006293
73 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 75 1656 0.0001014 0.006293
74 REGULATION OF NEURON DIFFERENTIATION 33 554 0.0001009 0.006293
75 MUSCLE CELL DEVELOPMENT 13 128 9.995e-05 0.006293
76 NEGATIVE REGULATION OF CHEMOTAXIS 8 51 0.0001086 0.00657
77 REGULATION OF OSTEOBLAST DIFFERENTIATION 12 112 0.0001099 0.00657
78 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 50 983 0.0001101 0.00657
79 CELL PART MORPHOGENESIS 36 633 0.0001249 0.007359
80 HEAD DEVELOPMENT 39 709 0.0001324 0.007698
81 REGULATION OF ACTIN FILAMENT BASED PROCESS 22 312 0.0001433 0.008235
82 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 51 1021 0.0001466 0.008319
83 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 81 1848 0.0001543 0.008647
84 REGULATION OF TRANSMEMBRANE TRANSPORT 27 426 0.0001582 0.008763
85 REGULATION OF CELLULAR COMPONENT SIZE 23 337 0.0001652 0.009044
86 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 7 41 0.0001691 0.009151
87 INTRACELLULAR SIGNAL TRANSDUCTION 71 1572 0.0001711 0.009152
88 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 47 926 0.0001861 0.00984
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 CELL PROJECTION 86 1786 2.872e-06 0.001677
2 INTRINSIC COMPONENT OF PLASMA MEMBRANE 77 1649 2.954e-05 0.005559
3 NEURON PROJECTION 50 942 3.807e-05 0.005559
4 PLASMA MEMBRANE PROTEIN COMPLEX 33 510 2.014e-05 0.005559
5 POSTSYNAPSE 26 378 5.566e-05 0.006501
6 GOLGI APPARATUS PART 47 893 7.993e-05 0.00778
7 SYNAPSE 41 754 0.0001145 0.008092
8 CELL SURFACE 41 757 0.0001247 0.008092
9 PLASMA MEMBRANE REGION 48 929 0.0001045 0.008092
10 NEURON PART 60 1265 0.0001577 0.009091
11 MEMBRANE REGION 55 1134 0.0001712 0.009091

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 ECM_receptor_interaction_hsa04512 9 82 0.0006546 0.01395
2 PI3K_Akt_signaling_pathway_hsa04151 22 352 0.0007522 0.01395
3 Focal_adhesion_hsa04510 15 199 0.0008049 0.01395
4 Hippo_signaling_pathway_hsa04390 12 154 0.001969 0.02559
5 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 11 139 0.002648 0.02699
6 Rap1_signaling_pathway_hsa04015 14 206 0.003114 0.02699
7 Gap_junction_hsa04540 8 88 0.004266 0.03169
8 Calcium_signaling_pathway_hsa04020 12 182 0.007534 0.04897
9 Regulation_of_actin_cytoskeleton_hsa04810 13 208 0.008543 0.04936
10 Oocyte_meiosis_hsa04114 9 124 0.01081 0.05586
11 Hedgehog_signaling_pathway_hsa04340 5 47 0.01182 0.05586
12 p53_signaling_pathway_hsa04115 6 68 0.01456 0.06307
13 Ras_signaling_pathway_hsa04014 13 232 0.01967 0.07869
14 Wnt_signaling_pathway_hsa04310 9 146 0.02822 0.1048
15 TGF_beta_signaling_pathway_hsa04350 6 84 0.03674 0.1274
16 cGMP_PKG_signaling_pathway_hsa04022 9 163 0.05101 0.1606
17 MAPK_signaling_pathway_hsa04010 14 295 0.05321 0.1606
18 Cytokine_cytokine_receptor_interaction_hsa04060 13 270 0.05558 0.1606
19 Tight_junction_hsa04530 9 170 0.06315 0.1657
20 Cell_adhesion_molecules_.CAMs._hsa04514 8 145 0.06373 0.1657
21 Phosphatidylinositol_signaling_system_hsa04070 6 99 0.07081 0.1753
22 Phagosome_hsa04145 8 152 0.079 0.1867
23 FoxO_signaling_pathway_hsa04068 7 132 0.09356 0.2057
24 Peroxisome_hsa04146 5 83 0.09648 0.2057
25 Cellular_senescence_hsa04218 8 160 0.09889 0.2057
26 Jak_STAT_signaling_pathway_hsa04630 8 162 0.1043 0.2074
27 Apelin_signaling_pathway_hsa04371 7 137 0.1083 0.2074
28 Ferroptosis_hsa04216 3 40 0.1117 0.2074
29 cAMP_signaling_pathway_hsa04024 9 198 0.1287 0.2308
30 AMPK_signaling_pathway_hsa04152 6 121 0.1449 0.2511
31 Notch_signaling_pathway_hsa04330 3 48 0.1657 0.2779
32 Endocytosis_hsa04144 10 244 0.1808 0.2938
33 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.2083 0.3282
34 ErbB_signaling_pathway_hsa04012 4 85 0.2385 0.3648
35 Phospholipase_D_signaling_pathway_hsa04072 6 146 0.2574 0.3824
36 Neuroactive_ligand_receptor_interaction_hsa04080 10 278 0.2992 0.4321
37 HIF_1_signaling_pathway_hsa04066 4 100 0.3368 0.4733
38 Adherens_junction_hsa04520 3 72 0.3534 0.4836
39 ABC_transporters_hsa02010 2 45 0.3815 0.5087
40 mTOR_signaling_pathway_hsa04150 5 151 0.455 0.5915
41 Cell_cycle_hsa04110 4 124 0.4942 0.6268
42 TNF_signaling_pathway_hsa04668 3 108 0.6169 0.7461
43 Apoptosis_hsa04210 3 138 0.7735 0.9142
44 Necroptosis_hsa04217 3 164 0.8629 0.9284
45 Sphingolipid_signaling_pathway_hsa04071 2 118 0.8643 0.9284
46 Lysosome_hsa04142 2 123 0.8792 0.9284
47 Autophagy_animal_hsa04140 2 128 0.8927 0.9284

Quest ID: 249e83c771e26237721a9308b0bbf3aa