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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-142-3p SIRT1 2.75 0 -1.04 0 miRanda -0.1 0 NA
2 hsa-miR-146b-5p SIRT1 1.76 0 -1.04 0 miRanda -0.13 0 NA
3 hsa-miR-181a-5p SIRT1 2.3 0 -1.04 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.19 0 NA
4 hsa-miR-181b-5p SIRT1 2.49 0 -1.04 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.15 0 NA
5 hsa-miR-186-5p SIRT1 1.47 0 -1.04 0 mirMAP; miRNATAP -0.11 0.0049 NA
6 hsa-miR-199a-5p SIRT1 0.59 0.06748 -1.04 0 miRNAWalker2 validate; MirTarget; PITA; miRanda; miRNATAP -0.12 0 NA
7 hsa-miR-199b-5p SIRT1 0.22 0.51949 -1.04 0 MirTarget; PITA; miRanda; miRNATAP -0.11 0 27145368 Downregulation of miR 199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling; Further dual-luciferase reporter gene assays revealed that SIRT1 was the direct target of miR-199b in CRC; The expression of miR-199b was inversely correlated with SIRT1 in CRC specimens; SIRT1 knockdown produced effects on biological behavior that were similar to those of miR-199b overexpression
8 hsa-miR-22-3p SIRT1 1.22 0 -1.04 0 MirTarget; miRNATAP -0.29 0 26499759 MicroRNA 22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma; In addition SIRT1 was identified as a direct target of miR-22 by a luciferase reporter assay; These findings showed that miR-22 functioned as tumor suppressor in RCC and blocked RCC growth and metastasis by directly targeting SIRT1 in RCC indicating a potential novel therapeutic role in RCC treatment
9 hsa-miR-2355-5p SIRT1 1.33 0 -1.04 0 MirTarget -0.13 1.0E-5 NA
10 hsa-miR-29b-3p SIRT1 1.66 0 -1.04 0 MirTarget -0.16 0 NA
11 hsa-miR-342-3p SIRT1 1.49 0 -1.04 0 PITA; miRanda -0.11 2.0E-5 NA
12 hsa-miR-34a-5p SIRT1 1.9 0 -1.04 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.12 0.00011 25982144; 21067862; 20687223; 22623155; 23954321; 26722316; 25826085; 27126903; 26518892; 18834855 5 Aminolevulinic acid mediated sonodynamic therapy induces anti tumor effects in malignant melanoma via p53 miR 34a Sirt1 axis; Therefore the p53 miR-34a and SIRT1 constituted a positive feedback loop;Sirt1 which is one of the target genes for miR-34a and related to drug-resistance was strikingly up-regulated in the 5-FU-resistant cells; The ectopic expression of miR-34a in the 5-FU-resistant cells inhibited growth as in the parental cells and attenuated the resistance to 5-FU through the down-regulation of Sirt1 and E2F3; These findings suggest that miR-34a targeting the Sirt1 and E2F3 genes could negatively regulate at least in part the resistance to 5-FU in human colorectal cancer DLD-1 cells;We aimed to elucidate the molecular mechanisms underlying paclitaxel resistance of hormone-refractory prostate cancer with a special focus on the roles of miR-34a and SIRT1; MiR-34a over-expression and SIRT1 knockdown attenuated paclitaxel resistance of PC3PR cells; Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Interestingly RES increased the intracellular expression level of miR-34a which down-regulated the target gene E2F3 and its downstream Sirt1 resulting in growth inhibition;miR 34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression; The role of miR-34a in regulating sirtuin 1 SIRT1 in prostate cancer remains unclear; The objective of the present study was to investigate the biological function and molecular mechanisms of miR-34a regulation of SIRT1 in human prostate cancer samples and the human prostate cancer cell line PC-3; Fresh prostate tissues were obtained from patients and the miR-34a expression in prostate cancer tissues was measured using reverse transcription-quantitative polymerase chain reaction RT-qPCR qPCR and western blotting were performed to assess the effects of miR-34a overexpression on SIRT1 regulation in PC-3 cells and the cell growth was assessed by Cell Counting Kit-8 CCK-8; SIRT1 expression levels in PC-3 cells with over-expression of miR-34a were significantly reduced compared with those in the negative control P<0.05; In conclusion miR-34a inhibits the human prostate cancer cell proliferation in part through the downregulation of SIRT1 expression;Dysregulation of the miR 34a SIRT1 axis inhibits breast cancer stemness; Sirtuin-1 SIRT1 is a direct target of miR-34a; Here we found low levels of miR-34a and high levels of SIRT1 in CD44+/CD24- breast cancer stem cells BCSCs; MiR-34a overexpression and knockdown of SIRT1 decreased proportion of BSCSs and mammosphere formation; In nude mice xenografts stable expression of miR-34a and silencing of SIRT1 reduced tumor burden; Taken together our results demonstrated that miR-34a inhibits proliferative potential of BCSCs in vitro and in vivo at least partially by downregulating SIRT1;In addition the present micellar system facilitated the escape of miR-34a from the endosome and release of DOX into the cell nucleus leading to the downregulation of silent information regulator 1 SIRT1 expression and inhibition of DU145 and PC3 androgen-independent prostate cancer cell proliferation;For example overexpressing miR-34a a master regulator of tumor suppression attenuates chemoresistance to 5-FU by downregulating silent information regulator 1 SIRT1 and E2F3;In PC3 cell ectopic expression of miR-34a decreased the SIRT1 mRNA and protein levels as well as protein levels of known direct target genes; Reporter assays revealed that miR-34a-induced SIRT1 inhibition occurred at the transcriptional but not post-transcriptional level despite the presence of a potential miR-34a binding site within its 3'-UTR
13 hsa-miR-576-5p SIRT1 2.2 0 -1.04 0 mirMAP -0.13 2.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELLULAR RESPONSE TO STRESS 64 1565 1.273e-21 5.924e-18
2 REGULATION OF RESPONSE TO STRESS 57 1468 4.313e-18 1.003e-14
3 MACROMOLECULE CATABOLIC PROCESS 44 926 4.322e-17 6.703e-14
4 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 38 720 2.812e-16 3.271e-13
5 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 54 1492 8.414e-16 7.83e-13
6 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 60 1848 1.985e-15 1.539e-12
7 POSITIVE REGULATION OF RESPONSE TO STIMULUS 61 1929 3.608e-15 2.398e-12
8 CATABOLIC PROCESS 58 1773 4.881e-15 2.839e-12
9 REGULATION OF PROTEOLYSIS 36 711 6.767e-15 3.499e-12
10 REGULATION OF CELLULAR RESPONSE TO STRESS 35 691 1.667e-14 7.755e-12
11 INTRACELLULAR SIGNAL TRANSDUCTION 53 1572 3.063e-14 1.296e-11
12 CELLULAR CATABOLIC PROCESS 48 1322 4.382e-14 1.568e-11
13 RESPONSE TO ABIOTIC STIMULUS 42 1024 4.075e-14 1.568e-11
14 CELL DEATH 41 1001 9.045e-14 3.006e-11
15 INTERSPECIES INTERACTION BETWEEN ORGANISMS 33 662 1.597e-13 4.644e-11
16 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 33 662 1.597e-13 4.644e-11
17 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 42 1087 3.014e-13 8.249e-11
18 REGULATION OF TRANSFERASE ACTIVITY 39 946 3.278e-13 8.474e-11
19 REGULATION OF CATABOLIC PROCESS 34 731 4.696e-13 1.15e-10
20 INTRINSIC APOPTOTIC SIGNALING PATHWAY 17 152 6.41e-13 1.491e-10
21 POSITIVE REGULATION OF PROTEOLYSIS 24 363 1.199e-12 2.658e-10
22 REGULATION OF CELL DEATH 48 1472 2.257e-12 4.774e-10
23 CHROMOSOME ORGANIZATION 39 1009 2.426e-12 4.908e-10
24 REGULATION OF PROTEIN MODIFICATION PROCESS 52 1710 3.15e-12 6.106e-10
25 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 41 1135 5.24e-12 9.753e-10
26 APOPTOTIC SIGNALING PATHWAY 21 289 5.574e-12 9.976e-10
27 DNA METABOLIC PROCESS 33 758 6.469e-12 1.115e-09
28 NEGATIVE REGULATION OF GENE EXPRESSION 47 1493 1.38e-11 2.294e-09
29 NEGATIVE REGULATION OF MOLECULAR FUNCTION 39 1079 1.861e-11 2.986e-09
30 NCRNA METABOLIC PROCESS 27 533 2.188e-11 3.285e-09
31 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 29 616 2.188e-11 3.285e-09
32 RRNA METABOLIC PROCESS 19 255 3.872e-11 5.63e-09
33 AGING 19 264 7.047e-11 9.472e-09
34 DNA REPAIR 25 480 7.115e-11 9.472e-09
35 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 18 233 7.125e-11 9.472e-09
36 POSITIVE REGULATION OF CELL DEATH 28 605 7.427e-11 9.599e-09
37 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 39 1152 1.297e-10 1.631e-08
38 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 48 1656 1.398e-10 1.712e-08
39 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 17 213 1.473e-10 1.757e-08
40 RESPONSE TO CYTOKINE 30 714 1.542e-10 1.794e-08
41 RESPONSE TO OXYGEN CONTAINING COMPOUND 43 1381 1.742e-10 1.977e-08
42 IMMUNE SYSTEM PROCESS 53 1984 2.403e-10 2.662e-08
43 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 14 139 3.041e-10 3.29e-08
44 POSITIVE REGULATION OF CELL COMMUNICATION 45 1532 3.957e-10 4.019e-08
45 RNA CATABOLIC PROCESS 17 227 3.973e-10 4.019e-08
46 REGULATION OF APOPTOTIC SIGNALING PATHWAY 21 363 3.913e-10 4.019e-08
47 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 15 171 4.932e-10 4.883e-08
48 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 27 616 5.544e-10 5.374e-08
49 REGULATION OF DNA METABOLIC PROCESS 20 340 7.83e-10 7.435e-08
50 REGULATION OF ORGANELLE ORGANIZATION 38 1178 9.117e-10 8.485e-08
51 RIBOSOME BIOGENESIS 19 308 9.616e-10 8.605e-08
52 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 44 1517 9.607e-10 8.605e-08
53 NCRNA PROCESSING 21 386 1.188e-09 1.043e-07
54 REGULATION OF OXIDATIVE STRESS INDUCED CELL DEATH 9 46 1.215e-09 1.047e-07
55 ORGANIC CYCLIC COMPOUND CATABOLIC PROCESS 22 427 1.294e-09 1.095e-07
56 POSITIVE REGULATION OF DNA METABOLIC PROCESS 15 185 1.479e-09 1.229e-07
57 REGULATION OF BINDING 18 283 1.666e-09 1.36e-07
58 POSITIVE REGULATION OF CATABOLIC PROCESS 21 395 1.796e-09 1.44e-07
59 CELLULAR RESPONSE TO CYTOKINE STIMULUS 26 606 1.861e-09 1.452e-07
60 REGULATION OF CELL CYCLE ARREST 12 108 1.873e-09 1.452e-07
61 POSITIVE REGULATION OF IMMUNE RESPONSE 25 563 1.952e-09 1.489e-07
62 REGULATION OF CELL CYCLE 33 949 2.172e-09 1.604e-07
63 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 22 2.166e-09 1.604e-07
64 REGULATION OF PROTEIN LOCALIZATION 33 950 2.23e-09 1.621e-07
65 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 25 573 2.789e-09 1.996e-07
66 REGULATION OF IMMUNE RESPONSE 31 858 2.881e-09 2.031e-07
67 REGULATION OF IMMUNE SYSTEM PROCESS 41 1403 3.251e-09 2.258e-07
68 PROTEIN CATABOLIC PROCESS 25 579 3.441e-09 2.355e-07
69 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 31 867 3.686e-09 2.486e-07
70 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 40 1360 4.377e-09 2.909e-07
71 NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS NONSENSE MEDIATED DECAY 12 118 5.218e-09 3.419e-07
72 CELL CYCLE 39 1316 5.75e-09 3.716e-07
73 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 19 351 8.261e-09 5.265e-07
74 MEMBRANE ORGANIZATION 31 899 8.611e-09 5.367e-07
75 RESPONSE TO OXIDATIVE STRESS 19 352 8.651e-09 5.367e-07
76 REGULATION OF PEPTIDASE ACTIVITY 20 392 8.95e-09 5.479e-07
77 REGULATION OF CYTOKINE PRODUCTION 24 563 9.28e-09 5.515e-07
78 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 10 77 9.363e-09 5.515e-07
79 REGULATION OF PROTEIN CATABOLIC PROCESS 20 393 9.342e-09 5.515e-07
80 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 17 280 9.636e-09 5.604e-07
81 CHROMATIN ORGANIZATION 26 663 1.19e-08 6.776e-07
82 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 12 127 1.209e-08 6.776e-07
83 CELLULAR RESPONSE TO OXIDATIVE STRESS 14 184 1.198e-08 6.776e-07
84 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE 19 361 1.301e-08 7.205e-07
85 REGULATION OF MITOCHONDRION ORGANIZATION 15 218 1.393e-08 7.535e-07
86 REGULATION OF INTRACELLULAR TRANSPORT 25 621 1.39e-08 7.535e-07
87 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 11 104 1.52e-08 8.039e-07
88 NEGATIVE REGULATION OF CELL COMMUNICATION 36 1192 1.509e-08 8.039e-07
89 POSITIVE REGULATION OF MOLECULAR FUNCTION 46 1791 1.699e-08 8.88e-07
90 REGULATION OF OXIDATIVE STRESS INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY 7 29 1.86e-08 9.617e-07
91 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 29 829 2.007e-08 1.026e-06
92 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 13 162 2.138e-08 1.07e-06
93 PROTEOLYSIS 36 1208 2.122e-08 1.07e-06
94 RNA PROCESSING 29 835 2.349e-08 1.163e-06
95 PROTEIN LOCALIZATION TO MEMBRANE 19 376 2.497e-08 1.223e-06
96 RESPONSE TO ENDOGENOUS STIMULUS 40 1450 2.608e-08 1.251e-06
97 CELLULAR RESPONSE TO ABIOTIC STIMULUS 16 263 2.589e-08 1.251e-06
98 HOMEOSTATIC PROCESS 38 1337 2.844e-08 1.336e-06
99 RESPONSE TO EXTERNAL STIMULUS 46 1821 2.815e-08 1.336e-06
100 REGULATION OF RESPONSE TO OXIDATIVE STRESS 9 65 2.956e-08 1.362e-06
101 REGULATION OF CELLULAR PROTEIN LOCALIZATION 23 552 2.936e-08 1.362e-06
102 PROTEIN LOCALIZATION TO ORGANELLE 23 556 3.351e-08 1.529e-06
103 REGULATION OF MITOTIC CELL CYCLE 21 468 3.478e-08 1.571e-06
104 REGULATION OF CELL CYCLE PROCESS 23 558 3.578e-08 1.601e-06
105 PROTEASOMAL PROTEIN CATABOLIC PROCESS 16 271 3.934e-08 1.743e-06
106 MRNA METABOLIC PROCESS 24 611 4.396e-08 1.93e-06
107 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 16 274 4.585e-08 1.994e-06
108 CELL CYCLE PROCESS 33 1081 5.096e-08 2.196e-06
109 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 12 145 5.367e-08 2.291e-06
110 MITOTIC CELL CYCLE 27 766 5.557e-08 2.329e-06
111 REGULATION OF CYTOPLASMIC TRANSPORT 21 481 5.543e-08 2.329e-06
112 I KAPPAB KINASE NF KAPPAB SIGNALING 9 70 5.742e-08 2.385e-06
113 TRANSLATIONAL INITIATION 12 146 5.793e-08 2.385e-06
114 NEGATIVE REGULATION OF CELL DEATH 29 872 5.988e-08 2.427e-06
115 RIBONUCLEOPROTEIN COMPLEX BIOGENESIS 20 440 6.074e-08 2.427e-06
116 REGULATION OF PHOSPHORUS METABOLIC PROCESS 42 1618 6.102e-08 2.427e-06
117 REGULATION OF CELL PROLIFERATION 40 1496 6.092e-08 2.427e-06
118 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 9 71 6.515e-08 2.569e-06
119 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 29 876 6.604e-08 2.575e-06
120 NEGATIVE REGULATION OF OXIDATIVE STRESS INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY 6 21 6.64e-08 2.575e-06
121 NEGATIVE REGULATION OF RESPONSE TO OXIDATIVE STRESS 7 35 7.59e-08 2.871e-06
122 CELLULAR AMIDE METABOLIC PROCESS 26 727 7.528e-08 2.871e-06
123 NEGATIVE REGULATION OF CELLULAR RESPONSE TO OXIDATIVE STRESS 7 35 7.59e-08 2.871e-06
124 CHROMATIN MODIFICATION 22 539 8.574e-08 3.177e-06
125 REGULATION OF CELLULAR LOCALIZATION 36 1277 8.579e-08 3.177e-06
126 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 38 1395 8.604e-08 3.177e-06
127 PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 11 123 8.799e-08 3.224e-06
128 POSITIVE REGULATION OF CATALYTIC ACTIVITY 40 1518 9.012e-08 3.276e-06
129 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 14 218 1.014e-07 3.657e-06
130 RESPONSE TO UV 11 126 1.128e-07 4.037e-06
131 PROTEIN TARGETING TO MEMBRANE 12 157 1.292e-07 4.589e-06
132 RESPONSE TO REACTIVE OXYGEN SPECIES 13 191 1.497e-07 5.275e-06
133 REGULATION OF LIGASE ACTIVITY 11 130 1.554e-07 5.438e-06
134 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 13 192 1.59e-07 5.522e-06
135 REGULATION OF DEFENSE RESPONSE 26 759 1.746e-07 6.017e-06
136 CELL CYCLE CHECKPOINT 13 194 1.794e-07 6.137e-06
137 REGULATION OF GENE EXPRESSION EPIGENETIC 14 229 1.86e-07 6.318e-06
138 NEGATIVE REGULATION OF CELL CYCLE 19 433 2.274e-07 7.666e-06
139 PEPTIDE METABOLIC PROCESS 22 571 2.316e-07 7.754e-06
140 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 13 200 2.551e-07 8.48e-06
141 NIK NF KAPPAB SIGNALING 9 83 2.574e-07 8.493e-06
142 RESPONSE TO OXYGEN LEVELS 16 311 2.594e-07 8.501e-06
143 REGULATION OF PROTEIN BINDING 12 168 2.704e-07 8.678e-06
144 MACROMOLECULAR COMPLEX ASSEMBLY 37 1398 2.685e-07 8.678e-06
145 REGULATION OF NECROTIC CELL DEATH 6 26 2.694e-07 8.678e-06
146 MULTI ORGANISM METABOLIC PROCESS 11 138 2.856e-07 9.101e-06
147 POSITIVE REGULATION OF CELL CYCLE ARREST 9 85 3.165e-07 1.002e-05
148 CELLULAR MACROMOLECULE LOCALIZATION 34 1234 3.526e-07 1.109e-05
149 NUCLEOTIDE EXCISION REPAIR 10 113 3.793e-07 1.184e-05
150 ORGANONITROGEN COMPOUND METABOLIC PROCESS 43 1796 3.916e-07 1.215e-05
151 REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 7 44 3.986e-07 1.228e-05
152 PROTEIN TARGETING 18 406 4.124e-07 1.263e-05
153 CYTOKINE MEDIATED SIGNALING PATHWAY 19 452 4.375e-07 1.331e-05
154 CELLULAR RESPONSE TO UV 8 66 5.083e-07 1.536e-05
155 NEGATIVE REGULATION OF CYTOPLASMIC TRANSPORT 10 117 5.25e-07 1.573e-05
156 RESPONSE TO RADIATION 18 413 5.288e-07 1.573e-05
157 ORGANONITROGEN COMPOUND BIOSYNTHETIC PROCESS 30 1024 5.307e-07 1.573e-05
158 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 12 179 5.357e-07 1.578e-05
159 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 10 118 5.683e-07 1.663e-05
160 CELL AGING 8 67 5.719e-07 1.663e-05
161 VIRAL LIFE CYCLE 15 290 5.8e-07 1.676e-05
162 RESPONSE TO ORGANIC CYCLIC COMPOUND 28 917 5.853e-07 1.681e-05
163 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 30 1036 6.768e-07 1.92e-05
164 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 30 1036 6.768e-07 1.92e-05
165 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 29 983 7.282e-07 2.053e-05
166 POSITIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 5 17 7.459e-07 2.091e-05
167 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 13 220 7.578e-07 2.111e-05
168 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 11 153 8.049e-07 2.203e-05
169 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 17 381 8.014e-07 2.203e-05
170 REGULATION OF PROTEIN STABILITY 13 221 7.977e-07 2.203e-05
171 CHROMATIN SILENCING 9 95 8.236e-07 2.241e-05
172 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 9 96 9.004e-07 2.436e-05
173 PROTEIN FOLDING 13 224 9.287e-07 2.498e-05
174 REGULATION OF KINASE ACTIVITY 25 776 9.485e-07 2.537e-05
175 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 14 263 9.907e-07 2.634e-05
176 COVALENT CHROMATIN MODIFICATION 16 345 1.031e-06 2.725e-05
177 ESTABLISHMENT OF PROTEIN LOCALIZATION TO MEMBRANE 14 264 1.036e-06 2.725e-05
178 CELLULAR HOMEOSTASIS 23 676 1.061e-06 2.773e-05
179 TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR 8 73 1.116e-06 2.9e-05
180 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 42 1805 1.167e-06 3.016e-05
181 CELLULAR SENESCENCE 6 33 1.217e-06 3.13e-05
182 REGULATION OF DNA REPLICATION 11 161 1.333e-06 3.409e-05
183 ERROR FREE TRANSLESION SYNTHESIS 5 19 1.377e-06 3.502e-05
184 RESPONSE TO TOPOLOGICALLY INCORRECT PROTEIN 11 163 1.506e-06 3.808e-05
185 REGULATION OF INNATE IMMUNE RESPONSE 16 357 1.611e-06 4.053e-05
186 REGULATION OF PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 9 103 1.634e-06 4.088e-05
187 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 18 448 1.696e-06 4.219e-05
188 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 11 168 2.025e-06 5.012e-05
189 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 9 106 2.08e-06 5.066e-05
190 REGULATION OF CELL CYCLE PHASE TRANSITION 15 321 2.062e-06 5.066e-05
191 POSITIVE REGULATION OF DEFENSE RESPONSE 16 364 2.072e-06 5.066e-05
192 RESPONSE TO TOXIC SUBSTANCE 13 241 2.103e-06 5.096e-05
193 REGULATION OF ORGAN MORPHOGENESIS 13 242 2.202e-06 5.308e-05
194 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 15 323 2.226e-06 5.34e-05
195 CELLULAR RESPONSE TO RADIATION 10 137 2.242e-06 5.35e-05
196 FC RECEPTOR SIGNALING PATHWAY 12 206 2.362e-06 5.609e-05
197 AMIDE BIOSYNTHETIC PROCESS 19 507 2.413e-06 5.698e-05
198 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 13 246 2.639e-06 6.201e-05
199 NON CANONICAL WNT SIGNALING PATHWAY 10 140 2.728e-06 6.378e-05
200 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 9 110 2.834e-06 6.561e-05
201 POSITIVE REGULATION OF LIGASE ACTIVITY 9 110 2.834e-06 6.561e-05
202 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 39 1672 2.866e-06 6.602e-05
203 REGULATION OF TRANSPORT 41 1804 2.907e-06 6.664e-05
204 POSITIVE REGULATION OF CELL CYCLE 15 332 3.118e-06 7.112e-05
205 GENE SILENCING 12 212 3.182e-06 7.223e-05
206 NEGATIVE REGULATION OF GENE EXPRESSION EPIGENETIC 9 112 3.292e-06 7.424e-05
207 NEGATIVE REGULATION OF INTRACELLULAR TRANSPORT 10 143 3.303e-06 7.424e-05
208 BASE EXCISION REPAIR 6 39 3.4e-06 7.569e-05
209 NUCLEOTIDE EXCISION REPAIR DNA INCISION 6 39 3.4e-06 7.569e-05
210 REGULATION OF NEURON DEATH 13 252 3.439e-06 7.62e-05
211 RESPONSE TO HORMONE 26 893 3.656e-06 8.063e-05
212 RESPONSE TO IONIZING RADIATION 10 145 3.742e-06 8.169e-05
213 NUCLEIC ACID PHOSPHODIESTER BOND HYDROLYSIS 13 254 3.75e-06 8.169e-05
214 ACTIVATION OF IMMUNE RESPONSE 17 427 3.757e-06 8.169e-05
215 TRANSLESION SYNTHESIS 6 41 4.602e-06 9.96e-05
216 POSITIVE REGULATION OF KINASE ACTIVITY 18 482 4.711e-06 0.0001015
217 NUCLEOTIDE EXCISION REPAIR DNA GAP FILLING 5 24 4.82e-06 0.0001034
218 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 24 799 5.282e-06 0.0001127
219 NEGATIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 8 90 5.507e-06 0.000117
220 PROTEIN MATURATION 13 265 5.948e-06 0.0001258
221 CELLULAR RESPONSE TO LIGHT STIMULUS 8 91 5.983e-06 0.000126
222 REGULATION OF PROTEIN TARGETING 14 307 6.02e-06 0.0001262
223 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 19 541 6.149e-06 0.0001277
224 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 19 541 6.149e-06 0.0001277
225 DNA BIOSYNTHETIC PROCESS 9 121 6.23e-06 0.0001288
226 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 10 154 6.407e-06 0.0001319
227 MACROMOLECULE DEACYLATION 7 67 7.346e-06 0.0001499
228 CELL REDOX HOMEOSTASIS 7 67 7.346e-06 0.0001499
229 RESPONSE TO TUMOR NECROSIS FACTOR 12 233 8.365e-06 0.00017
230 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 13 8.449e-06 0.0001709
231 POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 11 196 8.929e-06 0.0001799
232 NEGATIVE REGULATION OF TRANSPORT 17 458 9.449e-06 0.0001895
233 RESPONSE TO BIOTIC STIMULUS 25 886 9.784e-06 0.0001954
234 REGULATION OF LIPID BIOSYNTHETIC PROCESS 9 128 9.857e-06 0.000196
235 REGULATION OF CHROMOSOME ORGANIZATION 13 278 9.957e-06 0.0001971
236 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 27 1008 1.078e-05 0.0002126
237 INTRACELLULAR PROTEIN TRANSPORT 23 781 1.155e-05 0.0002239
238 PROTEIN COMPLEX BIOGENESIS 29 1132 1.15e-05 0.0002239
239 POSITIVE REGULATION OF CYTOKINE PRODUCTION 15 370 1.147e-05 0.0002239
240 PROTEIN COMPLEX ASSEMBLY 29 1132 1.15e-05 0.0002239
241 CELLULAR RESPONSE TO SUPEROXIDE 4 14 1.173e-05 0.0002255
242 CELLULAR RESPONSE TO OXYGEN RADICAL 4 14 1.173e-05 0.0002255
243 SINGLE ORGANISM CELLULAR LOCALIZATION 25 898 1.23e-05 0.0002354
244 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 10 167 1.308e-05 0.0002474
245 G1 DNA DAMAGE CHECKPOINT 7 73 1.304e-05 0.0002474
246 ACTIVATION OF INNATE IMMUNE RESPONSE 11 204 1.302e-05 0.0002474
247 DNA SYNTHESIS INVOLVED IN DNA REPAIR 7 74 1.427e-05 0.0002688
248 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 6 50 1.501e-05 0.0002817
249 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 21 684 1.532e-05 0.0002863
250 REGULATION OF DNA REPAIR 7 75 1.56e-05 0.0002903
251 NEGATIVE REGULATION OF NEURON DEATH 10 171 1.608e-05 0.000298
252 REGULATION OF AUTOPHAGY 12 249 1.629e-05 0.0003008
253 REGULATION OF GROWTH 20 633 1.637e-05 0.0003012
254 RESPONSE TO INORGANIC SUBSTANCE 17 479 1.685e-05 0.0003086
255 PROTEIN LOCALIZATION 39 1805 1.723e-05 0.0003144
256 REGULATION OF CELLULAR KETONE METABOLIC PROCESS 10 173 1.778e-05 0.0003231
257 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 11 211 1.784e-05 0.0003231
258 DETOXIFICATION 7 77 1.856e-05 0.0003347
259 REGULATION OF RNA STABILITY 9 139 1.915e-05 0.0003427
260 MITOTIC CELL CYCLE CHECKPOINT 9 139 1.915e-05 0.0003427
261 PHOSPHORYLATION 30 1228 1.988e-05 0.0003544
262 NEGATIVE REGULATION OF CELL CYCLE PROCESS 11 214 2.035e-05 0.0003613
263 NEGATIVE REGULATION OF CELL PROLIFERATION 20 643 2.049e-05 0.0003625
264 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 16 437 2.058e-05 0.0003626
265 INTRINSIC APOPTOTIC SIGNALING PATHWAY BY P53 CLASS MEDIATOR 6 53 2.112e-05 0.0003694
266 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 6 53 2.112e-05 0.0003694
267 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 5 32 2.13e-05 0.0003712
268 NEGATIVE REGULATION OF PROTEIN BINDING 7 79 2.197e-05 0.0003814
269 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 11 216 2.218e-05 0.0003836
270 REGULATION OF CELL DIFFERENTIATION 34 1492 2.23e-05 0.0003843
271 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 24 873 2.278e-05 0.0003897
272 FC EPSILON RECEPTOR SIGNALING PATHWAY 9 142 2.27e-05 0.0003897
273 RESPONSE TO EXTRACELLULAR STIMULUS 16 441 2.299e-05 0.0003918
274 POSTREPLICATION REPAIR 6 54 2.355e-05 0.0003984
275 REGULATION OF MITOCHONDRIAL MEMBRANE POTENTIAL 6 54 2.355e-05 0.0003984
276 CELLULAR RESPONSE TO OXYGEN LEVELS 9 143 2.401e-05 0.0004047
277 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 9 144 2.537e-05 0.0004262
278 DNA GEOMETRIC CHANGE 7 81 2.588e-05 0.0004332
279 REGULATION OF HOMEOSTATIC PROCESS 16 447 2.707e-05 0.0004515
280 T CELL RECEPTOR SIGNALING PATHWAY 9 146 2.83e-05 0.0004686
281 DNA INTEGRITY CHECKPOINT 9 146 2.83e-05 0.0004686
282 REGULATION OF PROTEIN IMPORT 10 183 2.886e-05 0.0004756
283 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 5 34 2.893e-05 0.0004756
284 RESPONSE TO LIPID 24 888 2.995e-05 0.0004906
285 RESPONSE TO OXYGEN RADICAL 4 18 3.467e-05 0.000566
286 PROTEIN COMPLEX SUBUNIT ORGANIZATION 34 1527 3.574e-05 0.0005815
287 CELLULAR MACROMOLECULAR COMPLEX ASSEMBLY 21 727 3.749e-05 0.0006078
288 POSITIVE REGULATION OF GENE EXPRESSION 37 1733 3.802e-05 0.0006142
289 CELL PROLIFERATION 20 672 3.819e-05 0.0006149
290 DNA DAMAGE RESPONSE DETECTION OF DNA DAMAGE 5 36 3.851e-05 0.000618
291 REGULATION OF CHROMATIN ORGANIZATION 9 152 3.887e-05 0.0006216
292 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 8 119 4.275e-05 0.0006813
293 REGULATION OF NEURON APOPTOTIC PROCESS 10 192 4.343e-05 0.0006892
294 ERROR PRONE TRANSLESION SYNTHESIS 4 19 4.355e-05 0.0006892
295 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 11 233 4.442e-05 0.0007006
296 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 16 470 4.934e-05 0.0007756
297 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 10 195 4.951e-05 0.0007757
298 RESPONSE TO LIGHT STIMULUS 12 280 5.141e-05 0.0008027
299 ESTABLISHMENT OF PROTEIN LOCALIZATION 32 1423 5.176e-05 0.0008054
300 HORMONE MEDIATED SIGNALING PATHWAY 9 158 5.261e-05 0.000816
301 PROTEIN ADP RIBOSYLATION 4 20 5.398e-05 0.0008289
302 ENDOPLASMIC RETICULUM CALCIUM ION HOMEOSTASIS 4 20 5.398e-05 0.0008289
303 POSITIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY 10 197 5.396e-05 0.0008289
304 REGULATION OF LIPID METABOLIC PROCESS 12 282 5.505e-05 0.0008398
305 ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN VIA MHC CLASS I 7 91 5.505e-05 0.0008398
306 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 10 199 5.874e-05 0.0008932
307 ANATOMICAL STRUCTURE HOMEOSTASIS 12 285 6.094e-05 0.0009236
308 REGULATION OF PROTEIN ACETYLATION 6 64 6.254e-05 0.0009449
309 REGULATION OF DNA BINDING 7 93 6.328e-05 0.0009529
310 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 162 6.388e-05 0.0009589
311 T HELPER 1 TYPE IMMUNE RESPONSE 4 21 6.612e-05 0.0009893
312 POSITIVE REGULATION OF BINDING 8 127 6.793e-05 0.001013
313 POSITIVE REGULATION OF TRANSPORT 24 936 6.86e-05 0.00102
314 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 37 1784 7.004e-05 0.001038
315 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 7 95 7.249e-05 0.001067
316 NEGATIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 7 95 7.249e-05 0.001067
317 IMMUNE EFFECTOR PROCESS 16 486 7.317e-05 0.001074
318 POSITIVE REGULATION OF CELL CYCLE PROCESS 11 247 7.514e-05 0.001086
319 ANTIGEN PROCESSING AND PRESENTATION OF EXOGENOUS PEPTIDE ANTIGEN VIA MHC CLASS I 6 66 7.446e-05 0.001086
320 MITOCHONDRION ORGANIZATION 18 594 7.513e-05 0.001086
321 RESPONSE TO VIRUS 11 247 7.514e-05 0.001086
322 REGULATION OF CELLULAR AMINO ACID METABOLIC PROCESS 6 66 7.446e-05 0.001086
323 PROTEIN PHOSPHORYLATION 24 944 7.825e-05 0.001127
324 REGULATION OF PROTEIN HOMODIMERIZATION ACTIVITY 4 22 8.014e-05 0.001144
325 RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 4 22 8.014e-05 0.001144
326 HISTONE H3 DEACETYLATION 4 22 8.014e-05 0.001144
327 PROTEIN STABILIZATION 8 131 8.453e-05 0.001199
328 NEGATIVE REGULATION OF BINDING 8 131 8.453e-05 0.001199
329 DNA REPLICATION 10 208 8.497e-05 0.001202
330 REGULATION OF CELL GROWTH 14 391 8.646e-05 0.001219
331 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 7 98 8.834e-05 0.001238
332 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 7 98 8.834e-05 0.001238
333 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 7 99 9.421e-05 0.001316
334 RESPONSE TO STEROID HORMONE 16 497 9.494e-05 0.001323
335 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 16 498 9.717e-05 0.00135
336 CELLULAR RESPONSE TO HORMONE STIMULUS 17 552 9.83e-05 0.001361
337 OXIDATION REDUCTION PROCESS 23 898 9.961e-05 0.001375
338 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 25 1021 1e-04 0.001377
339 MITOTIC DNA INTEGRITY CHECKPOINT 7 100 0.0001004 0.001378
340 NEGATIVE REGULATION OF LIPID BIOSYNTHETIC PROCESS 5 44 0.0001035 0.001412
341 ANTIGEN PROCESSING AND PRESENTATION 10 213 0.0001034 0.001412
342 NEGATIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 8 135 0.0001044 0.00142
343 NEGATIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 6 71 0.0001123 0.001523
344 ANTIGEN PROCESSING AND PRESENTATION OF PEPTIDE ANTIGEN 9 177 0.0001259 0.001704
345 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 39 1977 0.0001265 0.001706
346 CELLULAR RESPONSE TO LIPID 15 457 0.0001273 0.001712
347 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 14 406 0.0001284 0.001718
348 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 7 104 0.0001285 0.001718
349 DEFENSE RESPONSE 28 1231 0.0001319 0.001759
350 CELLULAR RESPONSE TO EXTERNAL STIMULUS 11 264 0.0001354 0.0018
351 REGULATION OF STEROID METABOLIC PROCESS 6 74 0.0001414 0.001875
352 RESPONSE TO NITROGEN COMPOUND 22 859 0.0001421 0.001878
353 NEURON DEATH 5 47 0.0001424 0.001878
354 RESPONSE TO ALCOHOL 13 362 0.0001503 0.001975
355 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 15 465 0.0001539 0.002017
356 RESPONSE TO AXON INJURY 5 48 0.0001576 0.002055
357 REGULATION OF NF KAPPAB IMPORT INTO NUCLEUS 5 48 0.0001576 0.002055
358 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 19 689 0.0001622 0.002108
359 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 13 365 0.000163 0.002112
360 REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 8 145 0.0001713 0.002214
361 RESPONSE TO HYDROGEN PEROXIDE 7 109 0.0001723 0.002221
362 REGULATION OF STEROID BIOSYNTHETIC PROCESS 5 49 0.000174 0.002237
363 POSITIVE REGULATION OF OXIDATIVE STRESS INDUCED CELL DEATH 3 11 0.0001871 0.002398
364 RESPONSE TO GAMMA RADIATION 5 50 0.0001917 0.002444
365 NEGATIVE REGULATION OF PHOSPHORYLATION 14 422 0.0001916 0.002444
366 REGULATION OF HYDROLASE ACTIVITY 29 1327 0.0001965 0.002498
367 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 6 79 0.000203 0.002574
368 ZYMOGEN ACTIVATION 7 112 0.0002039 0.002579
369 NECROTIC CELL DEATH 4 28 0.0002133 0.002683
370 POSITIVE REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 4 28 0.0002133 0.002683
371 POSITIVE REGULATION OF CHROMOSOME ORGANIZATION 8 150 0.0002161 0.002711
372 ESTABLISHMENT OF LOCALIZATION IN CELL 34 1676 0.0002183 0.00273
373 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 26 1142 0.0002298 0.002867
374 POSITIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 5 52 0.0002311 0.002875
375 REGULATION OF FIBROBLAST PROLIFERATION 6 81 0.0002329 0.002889
376 NEGATIVE REGULATION OF PROTEOLYSIS 12 329 0.0002339 0.002894
377 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 8 152 0.0002366 0.00292
378 NUCLEOTIDE EXCISION REPAIR PREINCISION COMPLEX ASSEMBLY 4 29 0.0002454 0.003021
379 FATTY ACID HOMEOSTASIS 3 12 0.0002475 0.003038
380 HYDROGEN PEROXIDE METABOLIC PROCESS 4 30 0.0002808 0.003429
381 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 9 197 0.0002807 0.003429
382 PROTEIN LOCALIZATION TO NUCLEUS 8 156 0.0002822 0.003437
383 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 11 289 0.000296 0.003597
384 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 5 55 0.0003014 0.003643
385 PROTEIN POLYUBIQUITINATION 10 243 0.0003009 0.003643
386 POSITIVE REGULATION OF CHROMATIN MODIFICATION 6 85 0.0003029 0.003651
387 IMMUNE RESPONSE 25 1100 0.0003134 0.003768
388 CELLULAR RESPONSE TO TOPOLOGICALLY INCORRECT PROTEIN 7 122 0.0003447 0.004134
389 REGENERATION 8 161 0.0003491 0.004175
390 APOPTOTIC MITOCHONDRIAL CHANGES 5 57 0.0003566 0.004254
391 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 11 296 0.0003627 0.004294
392 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR 4 32 0.0003623 0.004294
393 REGULATION OF ACTIN CYTOSKELETON REORGANIZATION 4 32 0.0003623 0.004294
394 REGULATION OF CELLULAR AMINE METABOLIC PROCESS 6 88 0.0003655 0.004305
395 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 6 88 0.0003655 0.004305
396 NEGATIVE REGULATION OF HOMEOSTATIC PROCESS 7 124 0.0003805 0.00447
397 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 19 740 0.0003968 0.00465
398 POSITIVE REGULATION OF CHOLESTEROL EFFLUX 3 14 0.000403 0.004653
399 HISTONE H3 K9 MODIFICATION 3 14 0.000403 0.004653
400 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 22 926 0.0004028 0.004653
401 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 3 14 0.000403 0.004653
402 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 20 801 0.0003985 0.004653
403 STEROID HORMONE MEDIATED SIGNALING PATHWAY 7 125 0.0003994 0.004653
404 REGULATION OF PROTEIN EXPORT FROM NUCLEUS 4 33 0.0004089 0.004697
405 REGULATION OF CELL AGING 4 33 0.0004089 0.004697
406 REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY 5 59 0.000419 0.0048
407 WNT SIGNALING PATHWAY 12 351 0.0004198 0.0048
408 CELL ACTIVATION 16 568 0.000426 0.004858
409 REGULATION OF CALCIUM ION TRANSPORT 9 209 0.0004328 0.004924
410 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 15 514 0.0004467 0.005069
411 PROTEIN UBIQUITINATION 17 629 0.0004529 0.005115
412 REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 12 354 0.0004529 0.005115
413 REGULATION OF PROTEIN DEACETYLATION 4 34 0.0004595 0.005165
414 NEGATIVE REGULATION OF CATION CHANNEL ACTIVITY 4 34 0.0004595 0.005165
415 REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 6 92 0.0004642 0.005205
416 NEGATIVE REGULATION OF CATION TRANSMEMBRANE TRANSPORT 5 61 0.0004894 0.005461
417 GLUTATHIONE METABOLIC PROCESS 5 61 0.0004894 0.005461
418 MULTICELLULAR ORGANISM METABOLIC PROCESS 6 93 0.0004919 0.005475
419 POSITIVE REGULATION OF RESPONSE TO OXIDATIVE STRESS 3 15 0.0004998 0.005551
420 NEGATIVE REGULATION OF CELL GROWTH 8 170 0.0005018 0.005559
421 NEURON APOPTOTIC PROCESS 4 35 0.0005145 0.005686
422 REGULATION OF RESPONSE TO EXTRACELLULAR STIMULUS 8 171 0.0005217 0.005725
423 REGULATION OF RESPONSE TO NUTRIENT LEVELS 8 171 0.0005217 0.005725
424 REGULATION OF DNA BIOSYNTHETIC PROCESS 6 94 0.0005208 0.005725
425 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 12 360 0.0005258 0.005756
426 REGULATION OF WNT SIGNALING PATHWAY 11 310 0.0005343 0.005836
427 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 6 95 0.000551 0.00599
428 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 6 95 0.000551 0.00599
429 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 7 132 0.0005544 0.006013
430 PEPTIDYL LYSINE MODIFICATION 11 312 0.0005636 0.006099
431 ENERGY DERIVATION BY OXIDATION OF ORGANIC COMPOUNDS 9 217 0.0005678 0.00613
432 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 36 0.000574 0.006182
433 MAINTENANCE OF LOCATION IN CELL 6 96 0.0005826 0.006246
434 REACTIVE OXYGEN SPECIES METABOLIC PROCESS 6 96 0.0005826 0.006246
435 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 9 218 0.0005869 0.006278
436 POSITIVE REGULATION OF SEQUESTERING OF CALCIUM ION 3 16 0.0006103 0.006499
437 POSITIVE REGULATION OF ACTIN CYTOSKELETON REORGANIZATION 3 16 0.0006103 0.006499
438 CELLULAR MODIFIED AMINO ACID METABOLIC PROCESS 9 220 0.0006266 0.006656
439 VIRION ASSEMBLY 4 37 0.0006382 0.006749
440 CHROMATIN SILENCING AT RDNA 4 37 0.0006382 0.006749
441 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 12 370 0.0006691 0.007059
442 REGULATION OF MAP KINASE ACTIVITY 11 319 0.000677 0.007126
443 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 6 99 0.0006858 0.007187
444 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 6 99 0.0006858 0.007187
445 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 5 66 0.0007041 0.007298
446 ACTIN MYOSIN FILAMENT SLIDING 4 38 0.0007074 0.007298
447 POSITIVE REGULATION OF DNA REPAIR 4 38 0.0007074 0.007298
448 REGULATION OF STEROL TRANSPORT 4 38 0.0007074 0.007298
449 MUSCLE FILAMENT SLIDING 4 38 0.0007074 0.007298
450 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 5 66 0.0007041 0.007298
451 REGULATION OF CHOLESTEROL TRANSPORT 4 38 0.0007074 0.007298
452 MAINTENANCE OF LOCATION 7 138 0.0007223 0.007435
453 MULTICELLULAR ORGANISMAL HOMEOSTASIS 10 272 0.0007258 0.007456
454 POSITIVE REGULATION OF STEROL TRANSPORT 3 17 0.0007353 0.007487
455 PEPTIDYL AMINO ACID MODIFICATION 20 841 0.0007334 0.007487
456 NEGATIVE REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 3 17 0.0007353 0.007487
457 POSITIVE REGULATION OF CHOLESTEROL TRANSPORT 3 17 0.0007353 0.007487
458 DNA CONFORMATION CHANGE 10 273 0.0007465 0.007584
459 REGULATION OF PROTEIN COMPLEX ASSEMBLY 12 375 0.0007522 0.007625
460 ERBB2 SIGNALING PATHWAY 4 39 0.0007817 0.007889
461 NEGATIVE REGULATION OF MITOCHONDRION ORGANIZATION 4 39 0.0007817 0.007889
462 MUSCLE TISSUE DEVELOPMENT 10 275 0.0007894 0.007951
463 MUSCLE ORGAN DEVELOPMENT 10 277 0.0008343 0.008384
464 NEGATIVE REGULATION OF TYPE I INTERFERON PRODUCTION 4 40 0.0008613 0.008637
465 CELL DEATH IN RESPONSE TO OXIDATIVE STRESS 3 18 0.0008754 0.008722
466 REGULATION OF B CELL APOPTOTIC PROCESS 3 18 0.0008754 0.008722
467 POSITIVE REGULATION OF PROTEIN DEACETYLATION 3 18 0.0008754 0.008722
468 REGULATION OF MEMBRANE PERMEABILITY 5 70 0.0009212 0.009159
469 NEGATIVE REGULATION OF ORGANELLE ORGANIZATION 12 387 0.0009875 0.009797
470 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 7 146 0.001006 0.00996
NumGOOverlapSizeP ValueAdj. P Value
1 IDENTICAL PROTEIN BINDING 38 1209 1.877e-09 1.744e-06
2 RNA BINDING 44 1598 4.742e-09 2.202e-06
3 ENZYME BINDING 43 1737 1.563e-07 4.839e-05
4 STRUCTURAL CONSTITUENT OF RIBOSOME 13 212 4.976e-07 0.0001156
5 POLY A RNA BINDING 32 1170 9.587e-07 0.0001781
6 PROTEIN DIMERIZATION ACTIVITY 31 1149 1.923e-06 0.0002866
7 MACROMOLECULAR COMPLEX BINDING 35 1399 2.16e-06 0.0002866
8 PROTEIN HOMODIMERIZATION ACTIVITY 23 722 3.211e-06 0.0003728
9 DAMAGED DNA BINDING 7 63 4.845e-06 0.0005002
10 PROTEIN DEACETYLASE ACTIVITY 6 43 6.13e-06 0.0005695
11 OXIDIZED NAD BINDING 4 13 8.449e-06 0.0007135
12 ANTIOXIDANT ACTIVITY 7 70 9.855e-06 0.0007629
13 CHROMATIN BINDING 16 435 1.946e-05 0.00139
14 NAD DEPENDENT PROTEIN DEACETYLASE ACTIVITY 4 17 2.719e-05 0.001579
15 DEACETYLASE ACTIVITY 6 55 2.62e-05 0.001579
16 HYDROLASE ACTIVITY ACTING ON CARBON NITROGEN BUT NOT PEPTIDE BONDS 9 143 2.401e-05 0.001579
17 HYDROLASE ACTIVITY ACTING ON CARBON NITROGEN BUT NOT PEPTIDE BONDS IN LINEAR AMIDES 7 84 3.281e-05 0.001793
18 PROTEIN DOMAIN SPECIFIC BINDING 19 624 4.429e-05 0.002286
19 ISOMERASE ACTIVITY 9 159 5.526e-05 0.002702
20 THREONINE TYPE PEPTIDASE ACTIVITY 4 21 6.612e-05 0.003071
21 PEPTIDASE ACTIVITY 19 663 9.874e-05 0.00432
22 ENDOPEPTIDASE ACTIVITY 15 448 0.0001023 0.00432
23 STRUCTURAL MOLECULE ACTIVITY 20 732 0.000123 0.00497
24 EXONUCLEASE ACTIVITY ACTIVE WITH EITHER RIBO OR DEOXYRIBONUCLEIC ACIDS AND PRODUCING 5 PHOSPHOMONOESTERS 5 46 0.0001284 0.00497
25 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY BINDING 5 47 0.0001424 0.005293
26 NAD ADP RIBOSYLTRANSFERASE ACTIVITY 4 26 0.0001584 0.005659
27 TRANSCRIPTION FACTOR BINDING 16 524 0.000174 0.005986
28 DNA DEPENDENT ATPASE ACTIVITY 6 79 0.000203 0.006735
29 NAD BINDING 5 53 0.000253 0.008104
30 TUMOR NECROSIS FACTOR RECEPTOR BINDING 4 30 0.0002808 0.008695
31 UBIQUITIN LIKE PROTEIN BINDING 7 121 0.0003278 0.009229
32 DISULFIDE OXIDOREDUCTASE ACTIVITY 4 31 0.0003197 0.009229
33 SINGLE STRANDED DNA DEPENDENT ATPASE ACTIVITY 3 13 0.0003192 0.009229
NumGOOverlapSizeP ValueAdj. P Value
1 CHROMOSOME 37 880 8.092e-13 4.725e-10
2 CHROMATIN 23 441 4.201e-10 1.227e-07
3 MITOCHONDRION 46 1633 9.383e-10 1.827e-07
4 NUCLEAR CHROMOSOME 24 523 2.21e-09 3.227e-07
5 CYTOSOLIC RIBOSOME 12 113 3.167e-09 3.699e-07
6 RIBONUCLEOPROTEIN COMPLEX 28 721 3.832e-09 3.73e-07
7 CYTOSOLIC PART 15 223 1.889e-08 1.576e-06
8 RIBOSOMAL SUBUNIT 13 163 2.302e-08 1.68e-06
9 NUCLEOLUS 29 848 3.285e-08 2.132e-06
10 RIBOSOME 13 226 1.026e-06 5.994e-05
11 NUCLEAR CHROMATIN 14 291 3.251e-06 0.0001726
12 REPLICATION FORK 7 62 4.346e-06 0.0002115
13 CYTOSOLIC SMALL RIBOSOMAL SUBUNIT 6 44 7.035e-06 0.0003064
14 HETEROCHROMATIN 7 67 7.346e-06 0.0003064
15 SMALL RIBOSOMAL SUBUNIT 7 68 8.115e-06 0.0003159
16 PML BODY 8 97 9.631e-06 0.0003515
17 ENVELOPE 28 1090 1.574e-05 0.0005407
18 CATALYTIC COMPLEX 27 1038 1.816e-05 0.0005893
19 CELL SUBSTRATE JUNCTION 15 398 2.688e-05 0.0008263
20 MITOCHONDRIAL PART 25 953 3.309e-05 0.0009662
21 CYTOSOLIC LARGE RIBOSOMAL SUBUNIT 6 61 4.757e-05 0.001323
22 PROTEASOME CORE COMPLEX 4 20 5.398e-05 0.001433
23 NUCLEOPLASM PART 20 708 7.845e-05 0.001992
24 CELL BODY 16 494 8.85e-05 0.002154
25 INTERCELLULAR BRIDGE 5 44 0.0001035 0.002418
26 PROTEASOME COMPLEX 6 76 0.000164 0.00364
27 MITOCHONDRIAL ENVELOPE 19 691 0.0001683 0.00364
28 RIBONUCLEOPROTEIN GRANULE 8 148 0.0001972 0.004112
29 CHROMOSOMAL REGION 12 330 0.0002405 0.004842
30 ANCHORING JUNCTION 15 489 0.0002644 0.005147
31 NUCLEAR BODY 12 349 0.0003989 0.007515
32 METHYLTRANSFERASE COMPLEX 6 90 0.0004126 0.007529
33 CONTRACTILE FIBER 9 211 0.0004638 0.008208
34 MITOCHONDRIAL MATRIX 13 412 0.0005205 0.008941
35 LARGE RIBOSOMAL SUBUNIT 6 95 0.000551 0.009194
36 PROTEIN DNA COMPLEX 8 175 0.0006077 0.009858

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa03010_Ribosome 12 92 2.83e-10 5.095e-08
2 hsa04920_Adipocytokine_signaling_pathway 6 68 8.812e-05 0.006926
3 hsa03050_Proteasome 5 45 0.0001154 0.006926
4 hsa04210_Apoptosis 6 89 0.0003885 0.01748
5 hsa04010_MAPK_signaling_pathway 10 268 0.0006477 0.02332
6 hsa03420_Nucleotide_excision_repair 4 45 0.001347 0.04041
7 hsa04670_Leukocyte_transendothelial_migration 6 117 0.001633 0.0411
8 hsa03430_Mismatch_repair 3 23 0.001827 0.0411
9 hsa04141_Protein_processing_in_endoplasmic_reticulum 7 168 0.002251 0.04208
10 hsa04722_Neurotrophin_signaling_pathway 6 127 0.002473 0.04208
11 hsa04380_Osteoclast_differentiation 6 128 0.002572 0.04208
12 hsa04623_Cytosolic_DNA.sensing_pathway 4 56 0.00303 0.04545
13 hsa04621_NOD.like_receptor_signaling_pathway 4 59 0.003663 0.05071
14 hsa00240_Pyrimidine_metabolism 5 99 0.004244 0.05456
15 hsa03030_DNA_replication 3 36 0.00665 0.07966
16 hsa04622_RIG.I.like_receptor_signaling_pathway 4 71 0.007081 0.07966
17 hsa04520_Adherens_junction 4 73 0.007802 0.08051
18 hsa00230_Purine_metabolism 6 162 0.008051 0.08051
19 hsa04662_B_cell_receptor_signaling_pathway 4 75 0.00857 0.08119
20 hsa00770_Pantothenate_and_CoA_biosynthesis 2 16 0.01239 0.1115
21 hsa04360_Axon_guidance 5 130 0.01304 0.1118
22 hsa04530_Tight_junction 5 133 0.01427 0.1168
23 hsa04150_mTOR_signaling_pathway 3 52 0.01818 0.1422
24 hsa04666_Fc_gamma_R.mediated_phagocytosis 4 95 0.01905 0.1429
25 hsa04390_Hippo_signaling_pathway 5 154 0.02514 0.181
26 hsa04151_PI3K_AKT_signaling_pathway 8 351 0.03567 0.2351
27 hsa03440_Homologous_recombination 2 28 0.03589 0.2351
28 hsa03020_RNA_polymerase 2 29 0.03829 0.2351
29 hsa03320_PPAR_signaling_pathway 3 70 0.03919 0.2351
30 hsa04730_Long.term_depression 3 70 0.03919 0.2351
31 hsa04370_VEGF_signaling_pathway 3 76 0.04807 0.2747
32 hsa04110_Cell_cycle 4 128 0.04883 0.2747
33 hsa04062_Chemokine_signaling_pathway 5 189 0.05284 0.2798
34 hsa04146_Peroxisome 3 79 0.05285 0.2798
35 hsa00051_Fructose_and_mannose_metabolism 2 36 0.05661 0.2911
36 hsa04350_TGF.beta_signaling_pathway 3 85 0.06306 0.3153
37 hsa04012_ErbB_signaling_pathway 3 87 0.06665 0.3243
38 hsa04310_Wnt_signaling_pathway 4 151 0.07921 0.3712
39 hsa04810_Regulation_of_actin_cytoskeleton 5 214 0.08042 0.3712
40 hsa04145_Phagosome 4 156 0.08682 0.3907
41 hsa00520_Amino_sugar_and_nucleotide_sugar_metabolism 2 48 0.09336 0.404
42 hsa04916_Melanogenesis 3 101 0.09428 0.404
43 hsa00480_Glutathione_metabolism 2 50 0.1 0.4187
44 hsa00983_Drug_metabolism_._other_enzymes 2 52 0.1068 0.4369
45 hsa04660_T_cell_receptor_signaling_pathway 3 108 0.1096 0.4383
46 hsa04114_Oocyte_meiosis 3 114 0.1234 0.4829
47 hsa00970_Aminoacyl.tRNA_biosynthesis 2 63 0.1461 0.5594
48 hsa03040_Spliceosome 3 128 0.1579 0.5921
49 hsa00190_Oxidative_phosphorylation 3 132 0.1682 0.5949
50 hsa04115_p53_signaling_pathway 2 69 0.1686 0.5949
51 hsa04650_Natural_killer_cell_mediated_cytotoxicity 3 136 0.1788 0.6034
52 hsa04910_Insulin_signaling_pathway 3 138 0.1841 0.6034
53 hsa04120_Ubiquitin_mediated_proteolysis 3 139 0.1868 0.6034
54 hsa04971_Gastric_acid_secretion 2 74 0.1877 0.6034
55 hsa04260_Cardiac_muscle_contraction 2 77 0.1993 0.6295
56 hsa04612_Antigen_processing_and_presentation 2 78 0.2032 0.6308
57 hsa04664_Fc_epsilon_RI_signaling_pathway 2 79 0.2071 0.632
58 hsa04540_Gap_junction 2 90 0.2505 0.7273
59 hsa04912_GnRH_signaling_pathway 2 101 0.2941 0.8114
60 hsa04972_Pancreatic_secretion 2 101 0.2941 0.8114
61 hsa04620_Toll.like_receptor_signaling_pathway 2 102 0.2981 0.8114
62 hsa04270_Vascular_smooth_muscle_contraction 2 116 0.3529 0.8709
63 hsa04510_Focal_adhesion 3 200 0.3615 0.8709
64 hsa04144_Endocytosis 3 203 0.3703 0.8709
65 hsa04142_Lysosome 2 121 0.3722 0.8709
66 hsa03013_RNA_transport 2 152 0.4854 1
67 hsa04014_Ras_signaling_pathway 2 236 0.7213 1

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 LINC00641 hsa-miR-142-3p;hsa-miR-146b-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-186-5p;hsa-miR-199a-5p;hsa-miR-199b-5p;hsa-miR-22-3p;hsa-miR-2355-5p;hsa-miR-29b-3p;hsa-miR-342-3p;hsa-miR-576-5p 12 SIRT1 Sponge network -1.851 0 -1.037 0 0.531
2 RP11-158K1.3 hsa-miR-142-3p;hsa-miR-146b-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-186-5p;hsa-miR-199a-5p;hsa-miR-199b-5p;hsa-miR-22-3p;hsa-miR-29b-3p;hsa-miR-342-3p;hsa-miR-576-5p 11 SIRT1 Sponge network -0.454 0.19049 -1.037 0 0.485
3 WDFY3-AS2 hsa-miR-142-3p;hsa-miR-146b-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-186-5p;hsa-miR-22-3p;hsa-miR-2355-5p;hsa-miR-29b-3p;hsa-miR-34a-5p;hsa-miR-576-5p 10 SIRT1 Sponge network -1.607 0 -1.037 0 0.401
4 RP11-531A24.5 hsa-miR-142-3p;hsa-miR-146b-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-186-5p;hsa-miR-22-3p;hsa-miR-2355-5p;hsa-miR-29b-3p;hsa-miR-342-3p;hsa-miR-576-5p 10 SIRT1 Sponge network -1.752 0 -1.037 0 0.385
5 AF131217.1 hsa-miR-142-3p;hsa-miR-146b-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-186-5p;hsa-miR-22-3p;hsa-miR-2355-5p;hsa-miR-29b-3p;hsa-miR-342-3p;hsa-miR-34a-5p;hsa-miR-576-5p 11 SIRT1 Sponge network -5.31 0 -1.037 0 0.351
6 CASC2 hsa-miR-142-3p;hsa-miR-146b-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-199a-5p;hsa-miR-22-3p;hsa-miR-2355-5p;hsa-miR-29b-3p;hsa-miR-342-3p;hsa-miR-576-5p 10 SIRT1 Sponge network -0.802 0.00027 -1.037 0 0.302

Quest ID: 2510b7853ba453989b1f467fa3a0e00a