Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-103a-3p CD274 0.99 0.00468 2.22 0.05161 miRNAWalker2 validate -0.48 0.01013 NA
2 hsa-miR-106a-5p CD274 3.99 0 2.22 0.05161 MirTarget; miRNATAP -0.24 0.00245 NA
3 hsa-miR-182-5p CD274 5.87 0 2.22 0.05161 mirMAP -0.34 5.0E-5 NA
4 hsa-miR-200a-3p CD274 6.34 0 2.22 0.05161 MirTarget -0.35 1.0E-5 NA
5 hsa-miR-20b-5p CD274 4.57 5.0E-5 2.22 0.05161 MirTarget; miRNATAP -0.19 0.0007 24468585 These findings suggest that miR-20b -21 and -130b up-regulated in colorectal cancer through inhibiting the expression of PTEN result in B7-H1 over-expression in colorectal cancer
6 hsa-miR-324-5p CD274 1.31 0.01168 2.22 0.05161 miRanda -0.47 0.00014 NA
7 hsa-miR-429 CD274 6.4 0 2.22 0.05161 miRanda -0.41 0 NA
8 hsa-miR-497-5p CD274 -1.44 0.02251 2.22 0.05161 MirTarget -0.38 0.00018 NA
9 hsa-miR-93-5p CD274 2.66 0 2.22 0.05161 MirTarget; miRNATAP -0.46 0.00064 NA
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.0003856 0.0694

Quest ID: 256c2d004cba81cc16893f86e7d9d93e