Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-125a-5p AIFM1 -0.01 0.99489 0.25 0.67324 miRanda -0.21 0.00378 NA
2 hsa-miR-125b-5p AIFM1 0.01 0.99415 0.25 0.67324 miRNATAP -0.11 0.01066 NA
3 hsa-miR-145-5p AIFM1 0.27 0.76637 0.25 0.67324 miRNATAP -0.13 0.00193 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death
4 hsa-miR-29a-3p AKT2 0.2 0.85995 -0.01 0.98435 MirTarget -0.12 0.00214 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis
5 hsa-miR-106a-5p AKT3 -0.82 0.02545 0.09 0.82989 miRNATAP -0.16 0.00858 NA
6 hsa-miR-106b-5p AKT3 -0.39 0.38964 0.09 0.82989 miRNATAP -0.31 0.00102 NA
7 hsa-miR-107 AKT3 -0.29 0.76966 0.09 0.82989 PITA; miRanda -0.29 0.00414 NA
8 hsa-miR-335-3p AKT3 0.07 0.89349 0.09 0.82989 mirMAP -0.16 0.00961 NA
9 hsa-miR-93-5p AKT3 -0.38 0.73231 0.09 0.82989 miRNATAP -0.27 0.00266 NA
10 hsa-miR-23b-3p APAF1 0.19 0.84836 0.26 0.50442 miRNATAP -0.1 0.00576 NA
11 hsa-let-7a-5p BCL2 0.05 0.97156 0 0.99871 miRNAWalker2 validate -0.16 0.048 24643702; 26915294 Estrogen combined with progesterone decreases cell proliferation and inhibits the expression of Bcl 2 via microRNA let 7a and miR 34b in ovarian cancer cells; Moreover the relative abundance of Bcl-2 and microRNAs let-7a miR-34b expressions were detected by quantitative real-time PCR qRT-PCR and Western blotting; E2 + P4 promoted the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells; When the expression of let-7a or/and miR-34b was inhibited using miRNA inhibitors E2 + P4 treatment did not change the protein level of Bcl-2; E2 + P4 significantly inhibited the cell survival promoted the cell apoptosis induced the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively
12 hsa-miR-15b-3p BCL2 0.08 0.84632 0 0.99871 mirMAP -0.19 0.00394 25594541; 26915294; 26884837; 18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2
13 hsa-miR-15b-5p BCL2 0.25 0.79071 0 0.99871 miRNAWalker2 validate; miRTarBase -0.22 0.00768 25594541; 26915294; 26884837; 18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2
14 hsa-miR-192-5p BCL2 -0 0.99638 0 0.99871 miRNAWalker2 validate -0.12 0.01734 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192
15 hsa-miR-21-5p BCL2 -0.52 0.64199 0 0.99871 miRNAWalker2 validate; miRTarBase -0.15 0.00126 21468550; 25994220; 25381586; 26555418; 23359184; 22964582; 21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells
16 hsa-miR-129-5p BIRC3 0.42 0.45424 -0.01 0.98965 miRanda -0.22 0.00017 NA
17 hsa-miR-107 CAPN2 -0.29 0.76966 -0.22 0.75885 miRanda -0.16 0.00224 NA
18 hsa-let-7c-5p CASP3 -0.2 0.87412 0.07 0.87356 MirTarget -0.1 0.00027 NA
19 hsa-miR-101-3p CASP3 -0.01 0.982 0.07 0.87356 MirTarget -0.14 7.0E-5 NA
20 hsa-miR-30a-5p CASP3 -0.16 0.8795 0.07 0.87356 miRNATAP -0.1 0.00039 NA
21 hsa-miR-30c-5p CASP3 -0.18 0.83318 0.07 0.87356 miRNATAP -0.14 0.00033 NA
22 hsa-miR-320c CASP3 0.09 0.78554 0.07 0.87356 MirTarget; miRanda -0.1 0.00087 NA
23 hsa-miR-125a-5p CASP6 -0.01 0.99489 -0.1 0.80319 miRanda -0.15 0.0371 NA
24 hsa-miR-106b-5p CASP7 -0.39 0.38964 0.28 0.53584 miRNAWalker2 validate -0.15 0.00046 22986525 MicroRNA 106b 25 cluster expression is associated with early disease recurrence and targets caspase 7 and focal adhesion in human prostate cancer; Moreover increased tumor miR-106b expression was associated with disease recurrence and the combination of high miR-106b and low CASP7 caspase-7 expressions in primary tumors was an independent predictor of early disease recurrence adjusted hazard ratio=4.1; 95% confidence interval: 1.6-12.3; The approach revealed that CASP7 is a direct target of miR-106b which was confirmed by western blot analysis and a 3'-untranslated region reporter assay; Moreover selected phenotypes induced by miR-106b knockdown in DU145 human prostate cancer cells did not develop when both miR-106b and CASP7 expression were inhibited
25 hsa-miR-18a-3p CASP7 -0.19 0.618 0.28 0.53584 MirTarget -0.12 0.00095 NA
26 hsa-miR-125a-3p CASP9 0.12 0.80054 -0.28 0.47903 miRanda -0.19 3.0E-5 NA
27 hsa-miR-342-5p CASP9 -0.2 0.63467 -0.28 0.47903 MirTarget -0.17 3.0E-5 NA
28 hsa-miR-20a-5p CHP2 -0.86 0.07026 -0.33 0.64805 MirTarget -0.33 0.01146 NA
29 hsa-miR-181c-5p CSF2RB -0.26 0.64547 -0.41 0.32071 MirTarget -0.19 0.00892 NA
30 hsa-miR-361-5p CYCS -0.28 0.72855 0.15 0.82426 miRNAWalker2 validate -0.16 0.01243 NA
31 hsa-miR-145-5p DFFA 0.27 0.76637 -0.21 0.66869 miRNAWalker2 validate; miRTarBase -0.14 1.0E-5 NA
32 hsa-miR-342-3p DFFA -0.23 0.73996 -0.21 0.66869 mirMAP -0.14 0.00044 NA
33 hsa-miR-365a-3p DFFB 0.34 0.57709 -0.28 0.38144 MirTarget -0.12 0.00828 NA
34 hsa-miR-130b-3p ENDOD1 -0.25 0.52407 0.48 0.39107 MirTarget -0.21 9.0E-5 NA
35 hsa-miR-181a-5p ENDOD1 -0.03 0.97581 0.48 0.39107 MirTarget -0.15 0.00642 NA
36 hsa-miR-181b-5p ENDOD1 -0.05 0.95293 0.48 0.39107 MirTarget -0.18 0.00081 NA
37 hsa-miR-181d-5p ENDOD1 -0.29 0.60439 0.48 0.39107 MirTarget -0.11 0.00565 NA
38 hsa-miR-26b-5p ENDOG 0.16 0.79078 0.13 0.73953 miRNAWalker2 validate -0.14 0.01892 NA
39 hsa-miR-361-5p FADD -0.28 0.72855 0.13 0.78042 MirTarget; miRanda; miRNATAP -0.15 0.00056 NA
40 hsa-miR-129-5p FAS 0.42 0.45424 0.19 0.66784 miRanda -0.12 0.00037 NA
41 hsa-miR-324-5p FASLG -0.36 0.49973 -0.38 0.44069 miRanda -0.26 0.04241 NA
42 hsa-miR-92a-3p FASLG 0.02 0.99144 -0.38 0.44069 miRNATAP -0.47 0.00193 NA
43 hsa-miR-92b-3p FASLG 0.45 0.64619 -0.38 0.44069 miRNATAP -0.27 0.00726 NA
44 hsa-miR-139-5p IKBKB -0.06 0.91481 -0.24 0.63061 miRanda -0.11 0.00111 NA
45 hsa-miR-125a-3p IL1A 0.12 0.80054 -0.62 0.11872 miRanda -0.3 0.01538 NA
46 hsa-miR-296-3p IL1B 0.31 0.47034 -0.59 0.17485 miRNATAP -0.15 0.02531 NA
47 hsa-miR-30a-3p IL1B 0.11 0.92065 -0.59 0.17485 MirTarget -0.21 0.01107 NA
48 hsa-miR-129-5p IL1RAP 0.42 0.45424 0.32 0.56867 miRanda -0.11 0.00324 NA
49 hsa-miR-93-5p IL1RAP -0.38 0.73231 0.32 0.56867 MirTarget -0.13 0.04658 NA
50 hsa-miR-1226-3p IRAK1 -0.04 0.94275 -0.36 0.59789 miRNAWalker2 validate -0.11 0.00112 NA
51 hsa-miR-92a-3p IRAK1 0.02 0.99144 -0.36 0.59789 miRNAWalker2 validate -0.16 0.00421 NA
52 hsa-miR-335-3p IRAK3 0.07 0.89349 -0.17 0.62581 mirMAP -0.1 0.03752 NA
53 hsa-miR-129-5p NFKB1 0.42 0.45424 0.05 0.9202 PITA; miRanda -0.11 1.0E-5 NA
54 hsa-let-7d-5p NGF 0.01 0.98839 0.06 0.86885 MirTarget -0.39 7.0E-5 NA
55 hsa-let-7f-5p NGF -0.4 0.69537 0.06 0.86885 MirTarget -0.17 0.013 NA
56 hsa-let-7g-5p NGF -0.32 0.66036 0.06 0.86885 MirTarget -0.37 5.0E-5 NA
57 hsa-let-7i-5p NGF -0.09 0.90231 0.06 0.86885 MirTarget -0.24 0.01497 NA
58 hsa-miR-320b NGF 0.3 0.70045 0.06 0.86885 miRanda -0.18 0.02089 NA
59 hsa-miR-429 NGF -0.6 0.12897 0.06 0.86885 miRanda -0.22 0.00171 NA
60 hsa-miR-98-5p NGF -0.05 0.91078 0.06 0.86885 MirTarget -0.19 0.00656 NA
61 hsa-miR-335-3p PIK3CG 0.07 0.89349 -0.35 0.33299 mirMAP -0.16 0.00995 NA
62 hsa-miR-17-5p PIK3R1 -0.64 0.32067 0.18 0.73919 MirTarget; TargetScan; miRNATAP -0.11 0.02188 NA
63 hsa-miR-221-3p PIK3R1 -0.26 0.74402 0.18 0.73919 MirTarget -0.21 2.0E-5 NA
64 hsa-miR-222-3p PIK3R1 -0.23 0.72665 0.18 0.73919 MirTarget -0.21 1.0E-5 NA
65 hsa-miR-629-3p PIK3R1 -0.46 0.20921 0.18 0.73919 MirTarget -0.18 7.0E-5 NA
66 hsa-miR-28-5p PIK3R2 -0.05 0.91096 0.14 0.83378 miRanda -0.1 0.0459 NA
67 hsa-miR-423-5p PIK3R2 -0.31 0.65889 0.14 0.83378 MirTarget -0.12 0.02884 NA
68 hsa-miR-1271-5p PIK3R3 -0.12 0.70353 -0.03 0.95678 mirMAP -0.2 0.0004 NA
69 hsa-miR-92a-3p PIK3R3 0.02 0.99144 -0.03 0.95678 MirTarget; miRNATAP -0.3 0.00023 NA
70 hsa-miR-92b-3p PIK3R3 0.45 0.64619 -0.03 0.95678 MirTarget; miRNATAP -0.18 0.00061 NA
71 hsa-miR-194-5p PPP3CA -0.14 0.80907 0.26 0.60892 MirTarget -0.14 1.0E-5 NA
72 hsa-miR-30c-5p PPP3CA -0.18 0.83318 0.26 0.60892 miRNATAP -0.12 0.01001 NA
73 hsa-miR-93-3p PPP3CA -0.02 0.96068 0.26 0.60892 miRNATAP -0.11 0.0175 NA
74 hsa-miR-93-5p PPP3CA -0.38 0.73231 0.26 0.60892 miRNATAP -0.14 0.00165 NA
75 hsa-miR-16-5p PPP3CB -0.2 0.74283 0.15 0.76092 miRNATAP -0.1 0.00014 NA
76 hsa-miR-361-5p PPP3CB -0.28 0.72855 0.15 0.76092 miRanda -0.11 0.01141 NA
77 hsa-miR-361-5p PPP3CC -0.28 0.72855 0.02 0.93808 miRanda -0.13 0.0292 NA
78 hsa-miR-141-3p PRKACB -0.37 0.42836 -0.12 0.76286 MirTarget; TargetScan; miRNATAP -0.15 0.00014 NA
79 hsa-miR-200a-3p PRKACB -0.8 0.14799 -0.12 0.76286 MirTarget; miRNATAP -0.15 0 NA
80 hsa-miR-200b-3p PRKACB -0.53 0.55597 -0.12 0.76286 MirTarget; TargetScan -0.13 2.0E-5 NA
81 hsa-miR-200c-3p PRKACB -0.33 0.81383 -0.12 0.76286 MirTarget; miRNATAP -0.16 0 NA
82 hsa-miR-30e-3p PRKACB 0.2 0.85742 -0.12 0.76286 mirMAP -0.12 0.02604 NA
83 hsa-miR-342-3p PRKAR1B -0.23 0.73996 -0.14 0.74922 mirMAP -0.11 0.03635 NA
84 hsa-miR-625-5p PRKAR1B -0.73 0.06055 -0.14 0.74922 mirMAP -0.13 5.0E-5 NA
85 hsa-miR-92a-3p PRKAR2A 0.02 0.99144 -0.08 0.85066 mirMAP -0.12 0.01023 NA
86 hsa-miR-107 PRKAR2B -0.29 0.76966 0.13 0.76775 miRanda -0.25 0.0006 NA
87 hsa-miR-186-5p PRKAR2B -0.25 0.70131 0.13 0.76775 mirMAP -0.21 0.00774 NA
88 hsa-miR-200b-3p PRKAR2B -0.53 0.55597 0.13 0.76775 TargetScan -0.1 0.03574 NA
89 hsa-miR-200c-3p PRKAR2B -0.33 0.81383 0.13 0.76775 miRNATAP -0.14 0.0066 NA
90 hsa-miR-361-5p PRKAR2B -0.28 0.72855 0.13 0.76775 miRanda -0.23 0.01527 NA
91 hsa-miR-129-5p TNFRSF10A 0.42 0.45424 -0.25 0.36985 miRanda -0.14 0.00011 NA
92 hsa-miR-145-5p TNFRSF10A 0.27 0.76637 -0.25 0.36985 MirTarget -0.17 0.00149 NA
93 hsa-miR-940 TNFRSF10B 0.19 0.67975 -0.16 0.73185 miRNAWalker2 validate -0.12 0.00013 NA
94 hsa-miR-146b-5p TNFRSF10D 0.03 0.96457 -0.39 0.25531 mirMAP -0.19 0.00133 NA
95 hsa-miR-26a-5p TNFRSF10D 0.05 0.95522 -0.39 0.25531 mirMAP -0.27 0.00606 NA
96 hsa-miR-26b-5p TNFRSF10D 0.16 0.79078 -0.39 0.25531 mirMAP -0.22 0.02108 NA
97 hsa-miR-129-5p TNFSF10 0.42 0.45424 -0.2 0.77958 miRanda -0.18 0.00111 NA
98 hsa-miR-139-5p TNFSF10 -0.06 0.91481 -0.2 0.77958 miRanda -0.21 0.01594 NA
99 hsa-miR-324-3p TRADD -0.24 0.713 0.14 0.73872 miRNATAP -0.17 0.00028 NA
100 hsa-miR-181a-2-3p XIAP 0.16 0.86725 0 0.99618 mirMAP -0.13 1.0E-5 NA
NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEATH 28 1001 3.159e-25 1.47e-21
2 REGULATION OF CELL DEATH 30 1472 2.397e-23 5.576e-20
3 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 32 1848 4.11e-23 6.375e-20
4 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 14 95 2.321e-22 2.16e-19
5 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 17 213 2.036e-22 2.16e-19
6 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 14 99 4.29e-22 3.327e-19
7 APOPTOTIC SIGNALING PATHWAY 18 289 8.691e-22 5.777e-19
8 ZYMOGEN ACTIVATION 14 112 2.66e-21 1.547e-18
9 POSITIVE REGULATION OF MOLECULAR FUNCTION 30 1791 6.951e-21 3.594e-18
10 RESPONSE TO OXYGEN CONTAINING COMPOUND 27 1381 4.119e-20 1.917e-17
11 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 14 154 2.736e-19 1.157e-16
12 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 27 1492 3.036e-19 1.177e-16
13 POSITIVE REGULATION OF CELL DEATH 20 605 8.134e-19 2.911e-16
14 EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 10 39 8.777e-19 2.917e-16
15 POSITIVE REGULATION OF RESPONSE TO STIMULUS 29 1929 9.836e-19 3.051e-16
16 NEGATIVE REGULATION OF CELL DEATH 22 872 2.642e-18 7.683e-16
17 REGULATION OF PEPTIDASE ACTIVITY 17 392 6.859e-18 1.877e-15
18 POSITIVE REGULATION OF CATALYTIC ACTIVITY 26 1518 7.956e-18 2.057e-15
19 PROTEIN MATURATION 15 265 1.623e-17 3.976e-15
20 INTRACELLULAR SIGNAL TRANSDUCTION 25 1572 2.787e-16 6.484e-14
21 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 13 3.583e-16 7.94e-14
22 REGULATION OF PROTEOLYSIS 19 711 3.897e-16 8.242e-14
23 POSITIVE REGULATION OF PROTEOLYSIS 15 363 1.76e-15 3.561e-13
24 POSITIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 17 4.034e-15 7.82e-13
25 RESPONSE TO CYTOKINE 18 714 7.941e-15 1.478e-12
26 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 10 98 1.755e-14 3.141e-12
27 POSITIVE REGULATION OF CELL COMMUNICATION 23 1532 2.732e-14 4.708e-12
28 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 22 3.507e-14 5.828e-12
29 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 18 799 5.477e-14 8.787e-12
30 RESPONSE TO NITROGEN COMPOUND 18 859 1.882e-13 2.919e-11
31 REGULATION OF HYDROLASE ACTIVITY 21 1327 2.173e-13 3.261e-11
32 POSITIVE REGULATION OF HYDROLASE ACTIVITY 18 905 4.558e-13 6.628e-11
33 IMMUNE SYSTEM PROCESS 24 1984 6.529e-13 9.206e-11
34 SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 7 33 8.621e-13 1.146e-10
35 EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 7 33 8.621e-13 1.146e-10
36 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 7 34 1.084e-12 1.401e-10
37 RESPONSE TO ENDOGENOUS STIMULUS 21 1450 1.211e-12 1.524e-10
38 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 10 153 1.642e-12 2.011e-10
39 CELLULAR RESPONSE TO NITROGEN COMPOUND 14 505 4.098e-12 4.89e-10
40 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 10 171 5.007e-12 5.824e-10
41 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 12 321 5.685e-12 6.452e-10
42 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 10 179 7.902e-12 8.754e-10
43 REGULATION OF PHOSPHORUS METABOLIC PROCESS 21 1618 9.912e-12 1.073e-09
44 NEURON DEATH 7 47 1.239e-11 1.31e-09
45 CYTOKINE MEDIATED SIGNALING PATHWAY 13 452 1.746e-11 1.805e-09
46 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 10 200 2.379e-11 2.359e-09
47 REGULATION OF APOPTOTIC SIGNALING PATHWAY 12 363 2.383e-11 2.359e-09
48 HOMEOSTATIC PROCESS 19 1337 3.061e-11 2.967e-09
49 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 7 55 3.944e-11 3.745e-09
50 RESPONSE TO ABIOTIC STIMULUS 17 1024 4.289e-11 3.992e-09
51 CELLULAR RESPONSE TO CYTOKINE STIMULUS 14 606 4.649e-11 4.16e-09
52 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 16 876 4.622e-11 4.16e-09
53 RESPONSE TO HORMONE 16 893 6.147e-11 5.397e-09
54 REGULATION OF KINASE ACTIVITY 15 776 9.909e-11 8.539e-09
55 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 10 233 1.072e-10 8.908e-09
56 RESPONSE TO TUMOR NECROSIS FACTOR 10 233 1.072e-10 8.908e-09
57 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 20 1656 1.408e-10 1.149e-08
58 NEURON APOPTOTIC PROCESS 6 35 1.629e-10 1.307e-08
59 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 17 1135 2.131e-10 1.681e-08
60 REGULATION OF PROTEIN MODIFICATION PROCESS 20 1710 2.498e-10 1.937e-08
61 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 16 1008 3.661e-10 2.793e-08
62 PROTEOLYSIS 17 1208 5.576e-10 4.185e-08
63 CELLULAR COMPONENT DISASSEMBLY INVOLVED IN EXECUTION PHASE OF APOPTOSIS 6 43 6.033e-10 4.456e-08
64 RESPONSE TO BIOTIC STIMULUS 15 886 6.239e-10 4.536e-08
65 RESPONSE TO LIPID 15 888 6.436e-10 4.607e-08
66 RESPONSE TO PEPTIDE 11 404 1.411e-09 9.948e-08
67 REGULATION OF TRANSFERASE ACTIVITY 15 946 1.534e-09 1.065e-07
68 RESPONSE TO BACTERIUM 12 528 1.74e-09 1.191e-07
69 EXECUTION PHASE OF APOPTOSIS 6 55 2.811e-09 1.895e-07
70 CELLULAR RESPONSE TO HORMONE STIMULUS 12 552 2.87e-09 1.908e-07
71 DNA CATABOLIC PROCESS 5 27 3.999e-09 2.62e-07
72 REGULATION OF IMMUNE RESPONSE 14 858 4.29e-09 2.773e-07
73 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 15 1036 5.283e-09 3.322e-07
74 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 15 1036 5.283e-09 3.322e-07
75 CHEMICAL HOMEOSTASIS 14 874 5.432e-09 3.37e-07
76 RESPONSE TO EXTERNAL STIMULUS 19 1821 5.757e-09 3.525e-07
77 PHOSPHORYLATION 16 1228 6.356e-09 3.841e-07
78 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 11 470 6.826e-09 4.072e-07
79 RESPONSE TO INORGANIC SUBSTANCE 11 479 8.305e-09 4.892e-07
80 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 7 118 9.2e-09 5.351e-07
81 CELLULAR RESPONSE TO PEPTIDE 9 274 1.055e-08 6.058e-07
82 IMMUNE RESPONSE 15 1100 1.185e-08 6.704e-07
83 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 12 1.196e-08 6.704e-07
84 ACTIVATION OF PROTEIN KINASE ACTIVITY 9 279 1.234e-08 6.833e-07
85 T CELL HOMEOSTASIS 5 34 1.362e-08 7.455e-07
86 PROTEIN PHOSPHORYLATION 14 944 1.444e-08 7.814e-07
87 CELLULAR GLUCOSE HOMEOSTASIS 6 75 1.886e-08 1.009e-06
88 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 19 1977 2.223e-08 1.175e-06
89 CELLULAR RESPONSE TO MECHANICAL STIMULUS 6 80 2.791e-08 1.459e-06
90 RESPONSE TO OXYGEN LEVELS 9 311 3.149e-08 1.628e-06
91 APOPTOTIC DNA FRAGMENTATION 4 15 3.281e-08 1.678e-06
92 ACTIVATION OF IMMUNE RESPONSE 10 427 3.634e-08 1.838e-06
93 REGULATION OF IMMUNE SYSTEM PROCESS 16 1403 4.176e-08 2.089e-06
94 POSITIVE REGULATION OF IMMUNE RESPONSE 11 563 4.357e-08 2.157e-06
95 INTRINSIC APOPTOTIC SIGNALING PATHWAY 7 152 5.323e-08 2.607e-06
96 RESPONSE TO METAL ION 9 333 5.657e-08 2.707e-06
97 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 17 5.701e-08 2.707e-06
98 ACTIVATION OF PROTEIN KINASE A ACTIVITY 4 17 5.701e-08 2.707e-06
99 INFLAMMATORY RESPONSE 10 454 6.456e-08 3.034e-06
100 RESPONSE TO TOXIC SUBSTANCE 8 241 6.958e-08 3.237e-06
101 NEGATIVE REGULATION OF MOLECULAR FUNCTION 14 1079 7.698e-08 3.546e-06
102 REGULATION OF RESPONSE TO STRESS 16 1468 7.846e-08 3.579e-06
103 RESPONSE TO ORGANIC CYCLIC COMPOUND 13 917 9.049e-08 4.088e-06
104 DNA CATABOLIC PROCESS ENDONUCLEOLYTIC 4 19 9.254e-08 4.14e-06
105 LYMPHOCYTE HOMEOSTASIS 5 50 1.009e-07 4.471e-06
106 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 9 360 1.099e-07 4.826e-06
107 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 5 51 1.117e-07 4.856e-06
108 POSITIVE REGULATION OF KINASE ACTIVITY 10 482 1.128e-07 4.859e-06
109 POSITIVE REGULATION OF DEFENSE RESPONSE 9 364 1.208e-07 5.108e-06
110 RENAL SYSTEM PROCESS 6 102 1.204e-07 5.108e-06
111 POSITIVE REGULATION OF PROTEIN IMPORT 6 104 1.352e-07 5.657e-06
112 CELLULAR RESPONSE TO ABIOTIC STIMULUS 8 263 1.362e-07 5.657e-06
113 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 9 370 1.387e-07 5.712e-06
114 CELLULAR RESPONSE TO EXTERNAL STIMULUS 8 264 1.402e-07 5.721e-06
115 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 10 514 2.046e-07 8.276e-06
116 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 23 2.1e-07 8.423e-06
117 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 5 59 2.348e-07 9.336e-06
118 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 12 829 2.518e-07 9.846e-06
119 REGULATION OF EXECUTION PHASE OF APOPTOSIS 4 24 2.516e-07 9.846e-06
120 LEUKOCYTE HOMEOSTASIS 5 60 2.557e-07 9.914e-06
121 APOPTOTIC NUCLEAR CHANGES 4 25 2.99e-07 1.15e-05
122 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 6 121 3.327e-07 1.269e-05
123 ACTIVATION OF INNATE IMMUNE RESPONSE 7 204 3.959e-07 1.498e-05
124 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 126 4.227e-07 1.586e-05
125 POSITIVE REGULATION OF NEURON DEATH 5 67 4.467e-07 1.663e-05
126 RESPONSE TO WOUNDING 10 563 4.722e-07 1.744e-05
127 RESPONSE TO MECHANICAL STIMULUS 7 210 4.815e-07 1.764e-05
128 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 6 129 4.856e-07 1.765e-05
129 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 6 132 5.561e-07 2.006e-05
130 REGULATION OF CATABOLIC PROCESS 11 731 5.981e-07 2.141e-05
131 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 8 323 6.492e-07 2.306e-05
132 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 5 74 7.363e-07 2.595e-05
133 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 7 228 8.369e-07 2.917e-05
134 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 4 32 8.4e-07 2.917e-05
135 FC EPSILON RECEPTOR SIGNALING PATHWAY 6 142 8.542e-07 2.944e-05
136 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 6 144 9.272e-07 3.172e-05
137 WOUND HEALING 9 470 1.031e-06 3.5e-05
138 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 10 616 1.07e-06 3.609e-05
139 RENAL WATER HOMEOSTASIS 4 34 1.08e-06 3.614e-05
140 CELLULAR RESPONSE TO STRESS 15 1565 1.182e-06 3.928e-05
141 RESPONSE TO OXIDATIVE STRESS 8 352 1.238e-06 4.086e-05
142 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 14 1360 1.287e-06 4.219e-05
143 NIK NF KAPPAB SIGNALING 5 83 1.307e-06 4.252e-05
144 REGULATION OF INNATE IMMUNE RESPONSE 8 357 1.376e-06 4.446e-05
145 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 7 246 1.391e-06 4.463e-05
146 TOLL LIKE RECEPTOR SIGNALING PATHWAY 5 85 1.471e-06 4.689e-05
147 REGULATION OF NEURON DEATH 7 252 1.633e-06 5.169e-05
148 CELLULAR RESPONSE TO GLUCAGON STIMULUS 4 38 1.707e-06 5.367e-05
149 CELLULAR RESPONSE TO INTERLEUKIN 1 5 88 1.748e-06 5.459e-05
150 LEUKOCYTE CELL CELL ADHESION 7 255 1.767e-06 5.48e-05
151 NEGATIVE REGULATION OF CELL COMMUNICATION 13 1192 1.8e-06 5.547e-05
152 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 7 258 1.909e-06 5.845e-05
153 AGING 7 264 2.224e-06 6.763e-05
154 RESPONSE TO CARBOHYDRATE 6 168 2.278e-06 6.883e-05
155 GLUCOSE HOMEOSTASIS 6 170 2.44e-06 7.278e-05
156 CARBOHYDRATE HOMEOSTASIS 6 170 2.44e-06 7.278e-05
157 CELLULAR HOMEOSTASIS 10 676 2.469e-06 7.316e-05
158 DEFENSE RESPONSE 13 1231 2.575e-06 7.488e-05
159 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 5 95 2.555e-06 7.488e-05
160 POSITIVE REGULATION OF GLUCOSE TRANSPORT 4 42 2.571e-06 7.488e-05
161 MULTICELLULAR ORGANISMAL HOMEOSTASIS 7 272 2.71e-06 7.832e-05
162 RESPONSE TO CORTICOSTEROID 6 176 2.983e-06 8.567e-05
163 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 11 867 3.159e-06 9.019e-05
164 INTERLEUKIN 1 MEDIATED SIGNALING PATHWAY 3 13 3.204e-06 9.037e-05
165 RESPONSE TO COBALT ION 3 13 3.204e-06 9.037e-05
166 REGULATION OF GLUCOSE TRANSPORT 5 100 3.291e-06 9.226e-05
167 REGULATION OF LIPID METABOLIC PROCESS 7 282 3.439e-06 9.583e-05
168 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 4 46 3.723e-06 0.0001029
169 REGULATION OF PROTEIN IMPORT 6 183 3.737e-06 0.0001029
170 REGULATION OF CELLULAR PROTEIN LOCALIZATION 9 552 3.859e-06 0.0001056
171 REGULATION OF CELL PROLIFERATION 14 1496 3.967e-06 0.0001079
172 RESPONSE TO ANTIBIOTIC 4 47 4.063e-06 0.0001089
173 REGULATION OF CAMP DEPENDENT PROTEIN KINASE ACTIVITY 3 14 4.072e-06 0.0001089
174 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 4 47 4.063e-06 0.0001089
175 POSITIVE REGULATION OF GENE EXPRESSION 15 1733 4.227e-06 0.0001124
176 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 12 1087 4.357e-06 0.0001152
177 RESPONSE TO GLUCAGON 4 48 4.425e-06 0.0001163
178 RESPONSE TO REACTIVE OXYGEN SPECIES 6 191 4.781e-06 0.000125
179 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 4 49 4.81e-06 0.000125
180 REGULATION OF NEURON APOPTOTIC PROCESS 6 192 4.927e-06 0.0001274
181 PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 5 109 5.03e-06 0.0001286
182 CELLULAR CHEMICAL HOMEOSTASIS 9 570 5.007e-06 0.0001286
183 T CELL APOPTOTIC PROCESS 3 15 5.082e-06 0.0001292
184 RESPONSE TO DRUG 8 431 5.549e-06 0.0001403
185 REGULATION OF PROTEIN TARGETING 7 307 6.008e-06 0.0001511
186 RESPONSE TO INTERLEUKIN 1 5 115 6.54e-06 0.0001636
187 POSITIVE REGULATION OF TRANSPORT 11 936 6.575e-06 0.0001636
188 REGULATION OF DEFENSE RESPONSE 10 759 6.89e-06 0.0001705
189 FC RECEPTOR SIGNALING PATHWAY 6 206 7.377e-06 0.0001816
190 ACTIVATION OF NF KAPPAB INDUCING KINASE ACTIVITY 3 17 7.57e-06 0.0001854
191 LYMPHOCYTE APOPTOTIC PROCESS 3 18 9.069e-06 0.0002209
192 MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS 4 58 9.487e-06 0.0002299
193 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 8 465 9.658e-06 0.0002328
194 REGULATION OF INTRACELLULAR TRANSPORT 9 621 9.983e-06 0.0002394
195 RESPONSE TO ESTROGEN 6 218 1.019e-05 0.0002419
196 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 6 218 1.019e-05 0.0002419
197 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 6 220 1.073e-05 0.0002535
198 REGULATION OF GLUCOSE IMPORT 4 60 1.087e-05 0.0002554
199 LYMPHOCYTE ACTIVATION 7 342 1.213e-05 0.0002837
200 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 1004 1.275e-05 0.0002967
201 NECROPTOTIC PROCESS 3 21 1.471e-05 0.0003405
202 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 6 233 1.487e-05 0.0003426
203 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 7 365 1.847e-05 0.0004232
204 CELLULAR RESPONSE TO OXYGEN LEVELS 5 143 1.886e-05 0.0004302
205 LEUKOCYTE APOPTOTIC PROCESS 3 23 1.953e-05 0.0004432
206 I KAPPAB KINASE NF KAPPAB SIGNALING 4 70 2.009e-05 0.0004517
207 WATER HOMEOSTASIS 4 70 2.009e-05 0.0004517
208 RESPONSE TO ESTRADIOL 5 146 2.085e-05 0.0004664
209 NEGATIVE REGULATION OF KINASE ACTIVITY 6 250 2.214e-05 0.0004928
210 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 7 381 2.432e-05 0.0005388
211 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 3 25 2.528e-05 0.0005574
212 DEVELOPMENTAL PROGRAMMED CELL DEATH 3 26 2.853e-05 0.0006232
213 REGULATION OF NECROTIC CELL DEATH 3 26 2.853e-05 0.0006232
214 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 14 1805 3.392e-05 0.0007374
215 INSULIN RECEPTOR SIGNALING PATHWAY 4 80 3.408e-05 0.0007376
216 NECROTIC CELL DEATH 3 28 3.583e-05 0.0007718
217 REGULATION OF CYTOKINE PRODUCTION 8 563 3.812e-05 0.0008174
218 POSITIVE REGULATION OF NIK NF KAPPAB SIGNALING 3 29 3.99e-05 0.0008516
219 LEUKOCYTE ACTIVATION 7 414 4.128e-05 0.000877
220 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 6 282 4.346e-05 0.0009191
221 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 3 30 4.426e-05 0.0009319
222 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 11 1152 4.557e-05 0.000955
223 REGULATION OF PROTEIN LOCALIZATION 10 950 4.773e-05 0.000996
224 HOMEOSTASIS OF NUMBER OF CELLS 5 175 4.966e-05 0.001027
225 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 88 4.958e-05 0.001027
226 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 12 1395 5.315e-05 0.001094
227 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 3 32 5.39e-05 0.0011
228 NEGATIVE REGULATION OF SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 3 32 5.39e-05 0.0011
229 CELL DEVELOPMENT 12 1426 6.581e-05 0.001337
230 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 13 1672 6.861e-05 0.001388
231 PROTEIN DEPHOSPHORYLATION 5 190 7.336e-05 0.001478
232 HEMOSTASIS 6 311 7.476e-05 0.001499
233 SINGLE ORGANISM CELL ADHESION 7 459 7.907e-05 0.001579
234 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 5 195 8.293e-05 0.001649
235 RESPONSE TO ACID CHEMICAL 6 319 8.598e-05 0.001702
236 SPLEEN DEVELOPMENT 3 39 9.82e-05 0.001936
237 NEGATIVE REGULATION OF CATABOLIC PROCESS 5 203 0.0001002 0.001968
238 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 3 40 0.000106 0.002063
239 REGULATION OF CYTOPLASMIC TRANSPORT 7 481 0.0001059 0.002063
240 RESPONSE TO HYDROGEN PEROXIDE 4 109 0.0001142 0.002214
241 LYMPHOCYTE DIFFERENTIATION 5 209 0.0001149 0.002219
242 REGULATION OF NIK NF KAPPAB SIGNALING 3 42 0.0001228 0.00236
243 RESPONSE TO AMINO ACID 4 112 0.0001269 0.002429
244 RESPONSE TO STEROID HORMONE 7 497 0.0001297 0.002473
245 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 1784 0.0001331 0.002527
246 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 6 351 0.000145 0.002743
247 REGULATION OF TRANSPORT 13 1804 0.0001489 0.002806
248 THYMOCYTE AGGREGATION 3 45 0.000151 0.002822
249 T CELL DIFFERENTIATION IN THYMUS 3 45 0.000151 0.002822
250 CELLULAR COMPONENT DISASSEMBLY 7 515 0.0001615 0.003007
251 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 4 120 0.0001655 0.003069
252 RESPONSE TO ALCOHOL 6 362 0.0001715 0.003167
253 T CELL DIFFERENTIATION 4 123 0.000182 0.003348
254 REGULATION OF LIPID KINASE ACTIVITY 3 48 0.0001832 0.003355
255 INOSITOL LIPID MEDIATED SIGNALING 4 124 0.0001878 0.003427
256 POSITIVE REGULATION OF CYTOKINE PRODUCTION 6 370 0.000193 0.003509
257 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 6 372 0.0001987 0.003598
258 RESPONSE TO UV 4 126 0.0001997 0.003601
259 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 3 50 0.0002069 0.003717
260 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 7 541 0.0002185 0.003895
261 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 7 541 0.0002185 0.003895
262 RESPONSE TO NICOTINE 3 51 0.0002195 0.003898
263 REGULATION OF T CELL MEDIATED IMMUNITY 3 52 0.0002325 0.004099
264 REGULATION OF LIPID CATABOLIC PROCESS 3 52 0.0002325 0.004099
265 SINGLE ORGANISM BEHAVIOR 6 384 0.0002358 0.004141
266 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 3 53 0.0002461 0.004305
267 COGNITION 5 251 0.0002694 0.004695
268 RESPONSE TO ALKALOID 4 137 0.0002751 0.004776
269 NEGATIVE REGULATION OF NECROTIC CELL DEATH 2 11 0.0002809 0.004817
270 REGULATION OF ORGANELLE ORGANIZATION 10 1178 0.0002816 0.004817
271 REGULATION OF NECROPTOTIC PROCESS 2 11 0.0002809 0.004817
272 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 2 11 0.0002809 0.004817
273 NUCLEIC ACID PHOSPHODIESTER BOND HYDROLYSIS 5 254 0.0002846 0.004851
274 CELL ACTIVATION 7 568 0.0002939 0.00499
275 REGULATION OF VITAMIN METABOLIC PROCESS 2 12 0.0003366 0.005634
276 REGULATION OF ENDOTHELIAL CELL DEVELOPMENT 2 12 0.0003366 0.005634
277 REGULATION OF ESTABLISHMENT OF ENDOTHELIAL BARRIER 2 12 0.0003366 0.005634
278 POSITIVE REGULATION OF INTERLEUKIN 2 BIOSYNTHETIC PROCESS 2 12 0.0003366 0.005634
279 IMMUNE SYSTEM DEVELOPMENT 7 582 0.0003405 0.005678
280 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 9 983 0.0003437 0.005711
281 CELLULAR RESPONSE TO INSULIN STIMULUS 4 146 0.0003504 0.005782
282 T CELL RECEPTOR SIGNALING PATHWAY 4 146 0.0003504 0.005782
283 PEPTIDYL SERINE MODIFICATION 4 148 0.000369 0.006067
284 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 3 61 0.0003733 0.006115
285 NEGATIVE REGULATION OF PHOSPHORYLATION 6 422 0.0003905 0.006376
286 HEPATOCYTE APOPTOTIC PROCESS 2 13 0.0003972 0.006462
287 CELL CELL ADHESION 7 608 0.0004428 0.007178
288 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 4 156 0.0004504 0.007277
289 PROTEIN OLIGOMERIZATION 6 434 0.0004531 0.007295
290 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 7 616 0.0004788 0.007682
291 DEPHOSPHORYLATION 5 286 0.0004899 0.007834
292 CELLULAR RESPONSE TO DRUG 3 67 0.0004921 0.007841
293 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 5 289 0.0005137 0.008158
294 CELLULAR RESPONSE TO BIOTIC STIMULUS 4 163 0.0005315 0.008381
295 NEGATIVE REGULATION OF INTERLEUKIN 12 PRODUCTION 2 15 0.0005331 0.008381
296 NEUROTROPHIN TRK RECEPTOR SIGNALING PATHWAY 2 15 0.0005331 0.008381
297 REGULATION OF CELLULAR LOCALIZATION 10 1277 0.000535 0.008381
298 LEUKOCYTE DIFFERENTIATION 5 292 0.0005384 0.008406
299 REGULATION OF INFLAMMATORY RESPONSE 5 294 0.0005553 0.008641
300 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 3 71 0.0005833 0.009047
301 CELLULAR RESPONSE TO LIPID 6 457 0.0005948 0.009194
NumGOOverlapSizeP ValueAdj. P Value
1 CYTOKINE RECEPTOR BINDING 10 271 4.69e-10 4.357e-07
2 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY BINDING 6 47 1.055e-09 4.902e-07
3 ENZYME BINDING 18 1737 1.915e-08 5.932e-06
4 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC PROCESS 4 15 3.281e-08 7.62e-06
5 DEATH RECEPTOR BINDING 4 18 7.318e-08 1.36e-05
6 KINASE REGULATOR ACTIVITY 7 186 2.117e-07 3.278e-05
7 DEATH RECEPTOR ACTIVITY 4 24 2.516e-07 3.339e-05
8 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 4 30 6.423e-07 6.63e-05
9 TUMOR NECROSIS FACTOR RECEPTOR BINDING 4 30 6.423e-07 6.63e-05
10 PROTEIN HETERODIMERIZATION ACTIVITY 9 468 9.948e-07 8.401e-05
11 KINASE BINDING 10 606 9.229e-07 8.401e-05
12 MOLECULAR FUNCTION REGULATOR 14 1353 1.211e-06 8.651e-05
13 ENZYME REGULATOR ACTIVITY 12 959 1.184e-06 8.651e-05
14 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 5 86 1.559e-06 0.0001035
15 KINASE ACTIVITY 11 842 2.382e-06 0.0001475
16 CYSTEINE TYPE ENDOPEPTIDASE REGULATOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 4 42 2.571e-06 0.0001493
17 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 43 2.83e-06 0.0001547
18 PROTEASE BINDING 5 104 3.993e-06 0.0002061
19 PROTEIN KINASE A CATALYTIC SUBUNIT BINDING 3 15 5.082e-06 0.0002485
20 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 4 51 5.654e-06 0.0002626
21 INTERLEUKIN 1 RECEPTOR BINDING 3 16 6.244e-06 0.0002762
22 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 11 992 1.139e-05 0.000481
23 CAMP BINDING 3 23 1.953e-05 0.0007778
24 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 70 2.009e-05 0.0007778
25 ENZYME INHIBITOR ACTIVITY 7 378 2.312e-05 0.000859
26 PROTEIN DIMERIZATION ACTIVITY 11 1149 4.449e-05 0.00159
27 KINASE INHIBITOR ACTIVITY 4 89 5.183e-05 0.001783
28 CYSTEINE TYPE PEPTIDASE ACTIVITY 5 184 6.302e-05 0.002086
29 PROTEIN SERINE THREONINE KINASE ACTIVITY 7 445 6.511e-05 0.002086
30 CYCLIC NUCLEOTIDE BINDING 3 36 7.709e-05 0.002387
31 PROTEIN KINASE ACTIVITY 8 640 9.373e-05 0.002721
32 RECEPTOR BINDING 12 1476 9.176e-05 0.002721
33 PROTEIN KINASE A BINDING 3 42 0.0001228 0.003456
34 PEPTIDASE REGULATOR ACTIVITY 5 214 0.0001284 0.003508
35 PROTEIN PHOSPHATASE BINDING 4 120 0.0001655 0.004394
36 IDENTICAL PROTEIN BINDING 10 1209 0.0003467 0.008948
NumGOOverlapSizeP ValueAdj. P Value
1 MEMBRANE MICRODOMAIN 10 288 8.464e-10 4.943e-07
2 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 9 237 2.978e-09 8.696e-07
3 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 4 20 1.155e-07 2.248e-05
4 CILIARY BASE 4 23 2.1e-07 3.066e-05
5 CATALYTIC COMPLEX 13 1038 3.776e-07 4.41e-05
6 PROTEIN KINASE COMPLEX 5 90 1.955e-06 0.0001882
7 MEMBRANE PROTEIN COMPLEX 12 1020 2.256e-06 0.0001882
8 TRANSFERASE COMPLEX 9 703 2.67e-05 0.001949
9 MEMBRANE REGION 11 1134 3.946e-05 0.00256
10 PLASMA MEMBRANE PROTEIN COMPLEX 7 510 0.0001521 0.008884
11 PHOSPHATASE COMPLEX 3 48 0.0001832 0.009725

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04210_Apoptosis 46 89 4.089e-115 7.361e-113
2 hsa04650_Natural_killer_cell_mediated_cytotoxicity 15 136 5.948e-22 5.354e-20
3 hsa04662_B_cell_receptor_signaling_pathway 12 75 1.08e-19 6.481e-18
4 hsa04722_Neurotrophin_signaling_pathway 13 127 1.24e-18 4.959e-17
5 hsa04380_Osteoclast_differentiation 13 128 1.378e-18 4.959e-17
6 hsa04660_T_cell_receptor_signaling_pathway 12 108 1.095e-17 3.284e-16
7 hsa04370_VEGF_signaling_pathway 11 76 1.345e-17 3.459e-16
8 hsa04010_MAPK_signaling_pathway 15 268 1.922e-17 4.326e-16
9 hsa04620_Toll.like_receptor_signaling_pathway 11 102 4.012e-16 8.025e-15
10 hsa04910_Insulin_signaling_pathway 11 138 1.223e-14 2.201e-13
11 hsa04151_PI3K_AKT_signaling_pathway 12 351 1.612e-11 2.638e-10
12 hsa04510_Focal_adhesion 10 200 2.379e-11 3.568e-10
13 hsa04014_Ras_signaling_pathway 10 236 1.215e-10 1.683e-09
14 hsa04062_Chemokine_signaling_pathway 9 189 4.047e-10 5.203e-09
15 hsa04973_Carbohydrate_digestion_and_absorption 6 44 6.974e-10 8.369e-09
16 hsa04914_Progesterone.mediated_oocyte_maturation 7 87 1.075e-09 1.21e-08
17 hsa04150_mTOR_signaling_pathway 6 52 1.984e-09 2.101e-08
18 hsa04115_p53_signaling_pathway 6 69 1.135e-08 1.135e-07
19 hsa04664_Fc_epsilon_RI_signaling_pathway 6 79 2.586e-08 2.45e-07
20 hsa04012_ErbB_signaling_pathway 6 87 4.634e-08 4.171e-07
21 hsa04630_Jak.STAT_signaling_pathway 7 155 6.088e-08 5.219e-07
22 hsa04666_Fc_gamma_R.mediated_phagocytosis 6 95 7.867e-08 6.436e-07
23 hsa04621_NOD.like_receptor_signaling_pathway 5 59 2.348e-07 1.837e-06
24 hsa04920_Adipocytokine_signaling_pathway 5 68 4.814e-07 3.61e-06
25 hsa04720_Long.term_potentiation 5 70 5.57e-07 4.01e-06
26 hsa04960_Aldosterone.regulated_sodium_reabsorption 4 42 2.571e-06 1.78e-05
27 hsa04114_Oocyte_meiosis 5 114 6.266e-06 4.178e-05
28 hsa04622_RIG.I.like_receptor_signaling_pathway 4 71 2.126e-05 0.0001367
29 hsa04310_Wnt_signaling_pathway 5 151 2.452e-05 0.0001522
30 hsa04070_Phosphatidylinositol_signaling_system 4 78 3.084e-05 0.0001851
31 hsa04020_Calcium_signaling_pathway 5 177 5.242e-05 0.0003044
32 hsa04670_Leukocyte_transendothelial_migration 4 117 0.0001502 0.0008446
33 hsa04360_Axon_guidance 4 130 0.0002251 0.001228
34 hsa04623_Cytosolic_DNA.sensing_pathway 3 56 0.0002898 0.001534
35 hsa04810_Regulation_of_actin_cytoskeleton 4 214 0.001463 0.007524
36 hsa04640_Hematopoietic_cell_lineage 2 88 0.01748 0.08738
37 hsa04530_Tight_junction 2 133 0.03755 0.1827
38 hsa04120_Ubiquitin_mediated_proteolysis 2 139 0.04068 0.1927
39 hsa04141_Protein_processing_in_endoplasmic_reticulum 2 168 0.05707 0.2634

Quest ID: 259fa0f6edee3de241b09c92612d2bca