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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7c-5p HMGA2 -1.71 0 1.12 0.01594 miRTarBase -0.68 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 SMALL MOLECULE METABOLIC PROCESS 42 1767 2.252e-18 1.048e-14
2 PRIMARY ALCOHOL METABOLIC PROCESS 10 47 3.709e-14 8.629e-11
3 LIPID METABOLIC PROCESS 30 1158 7.346e-14 1.139e-10
4 ETHANOL METABOLIC PROCESS 7 14 2.602e-13 2.422e-10
5 ORGANIC ACID METABOLIC PROCESS 27 953 2.131e-13 2.422e-10
6 RESPONSE TO HORMONE 26 893 3.501e-13 2.715e-10
7 RESPONSE TO OXYGEN CONTAINING COMPOUND 31 1381 1.134e-12 7.54e-10
8 RESPONSE TO ENDOGENOUS STIMULUS 30 1450 2.255e-11 1.311e-08
9 CELLULAR RESPONSE TO HORMONE STIMULUS 19 552 5.008e-11 2.589e-08
10 RESPONSE TO STEROID HORMONE 18 497 7.521e-11 3.5e-08
11 RESPONSE TO LIPID 23 888 1.068e-10 4.518e-08
12 SMALL MOLECULE CATABOLIC PROCESS 15 328 1.348e-10 5.228e-08
13 PLATELET DEGRANULATION 10 107 1.951e-10 6.984e-08
14 RESPONSE TO NITROGEN COMPOUND 22 859 3.612e-10 1.12e-07
15 REGULATION OF HORMONE LEVELS 17 478 3.542e-10 1.12e-07
16 SINGLE ORGANISM CATABOLIC PROCESS 23 957 4.631e-10 1.347e-07
17 RESPONSE TO ALCOHOL 15 362 5.298e-10 1.45e-07
18 POSITIVE REGULATION OF GLUCOSE METABOLIC PROCESS 7 36 5.77e-10 1.492e-07
19 RESPONSE TO ORGANIC CYCLIC COMPOUND 22 917 1.225e-09 3.001e-07
20 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 16 482 3.309e-09 6.695e-07
21 RESPONSE TO INORGANIC SUBSTANCE 16 479 3.028e-09 6.695e-07
22 CELLULAR HORMONE METABOLIC PROCESS 9 104 3.272e-09 6.695e-07
23 ALCOHOL METABOLIC PROCESS 14 348 3.058e-09 6.695e-07
24 RESPONSE TO ESTRADIOL 10 146 4.165e-09 8.075e-07
25 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 30 1805 4.415e-09 8.217e-07
26 NEGATIVE REGULATION OF COAGULATION 7 48 4.839e-09 8.417e-07
27 OXIDATION REDUCTION PROCESS 21 898 4.884e-09 8.417e-07
28 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 23 1087 5.319e-09 8.839e-07
29 MONOCARBOXYLIC ACID METABOLIC PROCESS 16 503 6.063e-09 9.728e-07
30 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 22 1008 6.964e-09 1.08e-06
31 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 30 1848 7.627e-09 1.145e-06
32 REGULATION OF PEPTIDE TRANSPORT 12 256 8.154e-09 1.186e-06
33 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 15 465 1.573e-08 2.217e-06
34 RESPONSE TO METAL ION 13 333 1.668e-08 2.217e-06
35 RESPONSE TO ESTROGEN 11 218 1.662e-08 2.217e-06
36 NEGATIVE REGULATION OF WOUND HEALING 7 58 1.895e-08 2.449e-06
37 RESPONSE TO PEPTIDE 14 404 2.025e-08 2.547e-06
38 NEGATIVE REGULATION OF EPITHELIAL CELL APOPTOTIC PROCESS 6 35 2.316e-08 2.835e-06
39 PROTEIN ACTIVATION CASCADE 8 99 4.368e-08 5.212e-06
40 FIBRINOLYSIS 5 21 6.26e-08 7.282e-06
41 RESPONSE TO XENOBIOTIC STIMULUS 8 105 6.936e-08 7.872e-06
42 REGULATION OF GLUCOSE METABOLIC PROCESS 8 106 7.471e-08 8.198e-06
43 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 24 1360 7.576e-08 8.198e-06
44 NEGATIVE REGULATION OF CELL DEATH 19 872 8.967e-08 9.483e-06
45 MONOSACCHARIDE METABOLIC PROCESS 10 202 9.224e-08 9.538e-06
46 RESPONSE TO INSULIN 10 205 1.059e-07 1.071e-05
47 POSITIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS 7 75 1.164e-07 1.153e-05
48 POSITIVE REGULATION OF GENE EXPRESSION 27 1733 1.244e-07 1.206e-05
49 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 20 1004 1.671e-07 1.587e-05
50 HORMONE METABOLIC PROCESS 9 164 1.747e-07 1.625e-05
51 CELLULAR LIPID METABOLIC PROCESS 19 913 1.829e-07 1.668e-05
52 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 10 218 1.878e-07 1.681e-05
53 NEGATIVE REGULATION OF ENDOTHELIAL CELL APOPTOTIC PROCESS 5 27 2.423e-07 2.088e-05
54 REGULATED EXOCYTOSIS 10 224 2.416e-07 2.088e-05
55 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 9 172 2.62e-07 2.216e-05
56 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 7 86 3.01e-07 2.501e-05
57 REGULATION OF CARBOHYDRATE BIOSYNTHETIC PROCESS 7 87 3.26e-07 2.661e-05
58 REGULATION OF COAGULATION 7 88 3.526e-07 2.829e-05
59 STEROID METABOLIC PROCESS 10 237 4.065e-07 3.206e-05
60 REGULATION OF PHOSPHORUS METABOLIC PROCESS 25 1618 4.822e-07 3.74e-05
61 NEGATIVE REGULATION OF MOLECULAR FUNCTION 20 1079 5.254e-07 4.008e-05
62 REGULATION OF EPITHELIAL CELL APOPTOTIC PROCESS 6 59 5.817e-07 4.366e-05
63 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 14 6.382e-07 4.714e-05
64 WOUND HEALING 13 470 8.839e-07 6.426e-05
65 REGULATION OF PROTEIN ACTIVATION CASCADE 5 35 9.432e-07 6.752e-05
66 REGULATION OF TRANSPORT 26 1804 1.018e-06 7.177e-05
67 NEGATIVE REGULATION OF PROTEOLYSIS 11 329 1.048e-06 7.276e-05
68 CARBOXYLIC ACID CATABOLIC PROCESS 9 205 1.144e-06 7.656e-05
69 RESPONSE TO WOUNDING 14 563 1.152e-06 7.656e-05
70 ORGANIC ACID CATABOLIC PROCESS 9 205 1.144e-06 7.656e-05
71 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 19 1036 1.241e-06 7.708e-05
72 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 19 1036 1.241e-06 7.708e-05
73 TERPENOID METABOLIC PROCESS 7 106 1.255e-06 7.708e-05
74 TRICARBOXYLIC ACID METABOLIC PROCESS 5 37 1.256e-06 7.708e-05
75 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 8 152 1.195e-06 7.708e-05
76 POSITIVE REGULATION OF TRANSPORT 18 936 1.259e-06 7.708e-05
77 REGULATION OF PEPTIDE SECRETION 9 209 1.344e-06 8.119e-05
78 REGULATION OF RESPONSE TO WOUNDING 12 413 1.441e-06 8.561e-05
79 NEGATIVE REGULATION OF RESPONSE TO WOUNDING 8 156 1.453e-06 8.561e-05
80 POSITIVE REGULATION OF GLYCOGEN METABOLIC PROCESS 4 17 1.5e-06 8.722e-05
81 REGULATION OF ENDOTHELIAL CELL APOPTOTIC PROCESS 5 42 2.402e-06 0.000138
82 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 8 168 2.533e-06 0.0001437
83 CATABOLIC PROCESS 25 1773 2.583e-06 0.0001448
84 GLUCOSE HOMEOSTASIS 8 170 2.767e-06 0.0001497
85 CARBOHYDRATE HOMEOSTASIS 8 170 2.767e-06 0.0001497
86 ACUTE PHASE RESPONSE 5 43 2.707e-06 0.0001497
87 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 16 799 3.157e-06 0.0001688
88 STEROID HORMONE MEDIATED SIGNALING PATHWAY 7 125 3.792e-06 0.0002005
89 REGULATION OF WOUND HEALING 7 126 3.998e-06 0.0002067
90 ISOPRENOID METABOLIC PROCESS 7 126 3.998e-06 0.0002067
91 CELLULAR RESPONSE TO LIPID 12 457 4.092e-06 0.0002078
92 REGULATION OF PROTEIN MATURATION 6 82 4.109e-06 0.0002078
93 CELLULAR GLUCURONIDATION 4 22 4.518e-06 0.0002261
94 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 5 48 4.718e-06 0.0002263
95 REGULATION OF CELL DEATH 22 1472 4.689e-06 0.0002263
96 EXOCYTOSIS 10 310 4.576e-06 0.0002263
97 HEMOSTASIS 10 311 4.708e-06 0.0002263
98 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 22 1492 5.824e-06 0.0002765
99 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 7 138 7.296e-06 0.0003429
100 REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS 5 53 7.747e-06 0.0003569
101 BLOOD COAGULATION FIBRIN CLOT FORMATION 4 25 7.722e-06 0.0003569
102 REGULATION OF HORMONE SECRETION 9 262 8.503e-06 0.000386
103 POSITIVE REGULATION OF PEPTIDE SECRETION 6 93 8.545e-06 0.000386
104 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 24 1784 9.613e-06 0.0004301
105 GLUCURONATE METABOLIC PROCESS 4 27 1.063e-05 0.0004665
106 URONIC ACID METABOLIC PROCESS 4 27 1.063e-05 0.0004665
107 CELLULAR RESPONSE TO NITROGEN COMPOUND 12 505 1.122e-05 0.000488
108 FLAVONOID METABOLIC PROCESS 4 28 1.235e-05 0.0005321
109 REGULATION OF GLUCOSE TRANSPORT 6 100 1.298e-05 0.0005541
110 RESPONSE TO EXTERNAL STIMULUS 24 1821 1.357e-05 0.0005739
111 DICARBOXYLIC ACID METABOLIC PROCESS 6 101 1.374e-05 0.0005761
112 RETINOL METABOLIC PROCESS 4 29 1.427e-05 0.0005899
113 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 7 153 1.433e-05 0.0005899
114 REGULATION OF LIPID METABOLIC PROCESS 9 282 1.53e-05 0.0006244
115 RESPONSE TO EXTRACELLULAR STIMULUS 11 441 1.707e-05 0.0006905
116 HORMONE MEDIATED SIGNALING PATHWAY 7 158 1.765e-05 0.0007079
117 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 18 1142 1.969e-05 0.0007829
118 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 14 724 2.045e-05 0.0008064
119 NEGATIVE REGULATION OF PROTEIN ACTIVATION CASCADE 3 11 2.124e-05 0.0008236
120 REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 5 65 2.123e-05 0.0008236
121 ALPHA AMINO ACID METABOLIC PROCESS 8 229 2.442e-05 0.0009391
122 RESPONSE TO ACTIVITY 5 69 2.842e-05 0.001084
123 POSITIVE REGULATION OF CELL COMMUNICATION 21 1532 2.965e-05 0.001121
124 POSITIVE REGULATION OF MAPK CASCADE 11 470 3.064e-05 0.001134
125 REGULATION OF GLYCOGEN METABOLIC PROCESS 4 35 3.072e-05 0.001134
126 POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE 7 172 3.049e-05 0.001134
127 ORGANONITROGEN COMPOUND METABOLIC PROCESS 23 1796 3.379e-05 0.001238
128 REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 4 36 3.443e-05 0.00125
129 POSITIVE REGULATION OF HORMONE SECRETION 6 119 3.493e-05 0.00125
130 NEGATIVE REGULATION OF CELL COMMUNICATION 18 1192 3.472e-05 0.00125
131 RESPONSE TO CORTICOSTEROID 7 176 3.532e-05 0.001254
132 POSITIVE REGULATION OF GLUCONEOGENESIS 3 13 3.654e-05 0.001288
133 ACUTE INFLAMMATORY RESPONSE 5 73 3.738e-05 0.001298
134 POSITIVE REGULATION OF CATABOLIC PROCESS 10 395 3.715e-05 0.001298
135 REGULATION OF GLUCONEOGENESIS 4 38 4.28e-05 0.001475
136 CELLULAR AMINO ACID METABOLIC PROCESS 9 332 5.484e-05 0.001876
137 VESICLE MEDIATED TRANSPORT 18 1239 5.745e-05 0.001951
138 REGULATION OF LIPID STORAGE 4 41 5.803e-05 0.001956
139 REGULATION OF BODY FLUID LEVELS 11 506 5.971e-05 0.001999
140 REGULATION OF CELLULAR CARBOHYDRATE CATABOLIC PROCESS 4 42 6.388e-05 0.002093
141 POSITIVE REGULATION OF GLUCOSE TRANSPORT 4 42 6.388e-05 0.002093
142 REGULATION OF CARBOHYDRATE CATABOLIC PROCESS 4 42 6.388e-05 0.002093
143 NEGATIVE REGULATION OF GENE EXPRESSION 20 1493 6.553e-05 0.002117
144 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 17 1135 6.528e-05 0.002117
145 REGULATION OF CELL PROLIFERATION 20 1496 6.738e-05 0.002162
146 REGULATION OF POLYSACCHARIDE METABOLIC PROCESS 4 43 7.016e-05 0.002236
147 DNA TEMPLATED TRANSCRIPTION INITIATION 7 202 8.441e-05 0.002672
148 POSITIVE REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 3 17 8.559e-05 0.002686
149 CELLULAR RESPONSE TO PEPTIDE 8 274 8.66e-05 0.002686
150 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 8 274 8.66e-05 0.002686
151 NEGATIVE REGULATION OF DNA BINDING 4 46 9.167e-05 0.002825
152 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 5 89 9.678e-05 0.002962
153 POSITIVE REGULATION OF RESPONSE TO STIMULUS 23 1929 0.0001018 0.003092
154 REGULATION OF HETEROTYPIC CELL CELL ADHESION 3 18 0.0001023 0.003092
155 REGULATION OF BINDING 8 283 0.0001083 0.003252
156 REGULATION OF NUCLEOSIDE METABOLIC PROCESS 4 49 0.0001176 0.003464
157 RESPONSE TO TRANSITION METAL NANOPARTICLE 6 148 0.0001176 0.003464
158 REGULATION OF ATP METABOLIC PROCESS 4 49 0.0001176 0.003464
159 REGULATION OF DNA BINDING 5 93 0.0001192 0.003489
160 REGULATION OF COENZYME METABOLIC PROCESS 4 50 0.0001274 0.003681
161 REGULATION OF COFACTOR METABOLIC PROCESS 4 50 0.0001274 0.003681
162 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 6 153 0.0001411 0.00405
163 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT5 PROTEIN 3 20 0.0001419 0.00405
164 REGULATION OF PROTEIN MODIFICATION PROCESS 21 1710 0.0001441 0.004089
165 REGULATION OF MAPK CASCADE 12 660 0.0001488 0.00417
166 REGULATION OF HUMORAL IMMUNE RESPONSE 4 52 0.0001485 0.00417
167 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 5 98 0.0001526 0.004238
168 CARBOHYDRATE METABOLIC PROCESS 12 662 0.000153 0.004238
169 CHEMICAL HOMEOSTASIS 14 874 0.0001544 0.004251
170 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 4 53 0.00016 0.004306
171 AEROBIC RESPIRATION 4 53 0.00016 0.004306
172 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 14 876 0.0001581 0.004306
173 POSITIVE REGULATION OF CELL SUBSTRATE ADHESION 5 99 0.0001601 0.004306
174 REGULATION OF RESPONSE TO STRESS 19 1468 0.0001612 0.004311
175 HEXOSE METABOLIC PROCESS 6 157 0.0001624 0.004318
176 REGULATION OF PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 3 21 0.0001649 0.00436
177 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 7 228 0.0001788 0.004701
178 REGULATION OF PROTEIN SECRETION 9 389 0.0001822 0.004763
179 REGULATION OF CELL DIFFERENTIATION 19 1492 0.0001987 0.005165
180 SECRETION BY CELL 10 486 0.0002051 0.005301
181 SECRETION 11 588 0.0002233 0.005739
182 REGULATION OF ERK1 AND ERK2 CASCADE 7 238 0.0002326 0.005929
183 RESPONSE TO CARBOHYDRATE 6 168 0.0002344 0.005929
184 RESPONSE TO ABIOTIC STIMULUS 15 1024 0.0002342 0.005929
185 RESPONSE TO ACID CHEMICAL 8 319 0.0002454 0.006142
186 POSITIVE REGULATION OF NUCLEOSIDE METABOLIC PROCESS 3 24 0.0002482 0.006142
187 POSITIVE REGULATION OF ATP METABOLIC PROCESS 3 24 0.0002482 0.006142
188 TISSUE DEVELOPMENT 19 1518 0.0002478 0.006142
189 RESPONSE TO TOXIC SUBSTANCE 7 241 0.000251 0.006179
190 REGULATION OF GLUCOSE IMPORT 4 60 0.0002592 0.006348
191 REGULATION OF CELLULAR LOCALIZATION 17 1277 0.0002695 0.006565
192 NEGATIVE REGULATION OF PEPTIDASE ACTIVITY 7 245 0.0002774 0.006722
193 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 14 926 0.0002797 0.006743
194 REGULATION OF PROTEOLYSIS 12 711 0.0002947 0.006995
195 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 4 62 0.0002942 0.006995
196 PIGMENT METABOLIC PROCESS 4 62 0.0002942 0.006995
197 POSITIVE REGULATION OF CELL DIFFERENTIATION 13 823 0.0003091 0.0073
198 OSSIFICATION 7 251 0.0003211 0.007528
199 CELLULAR RESPONSE TO ALCOHOL 5 115 0.000322 0.007528
200 COFACTOR METABOLIC PROCESS 8 334 0.000334 0.007772
201 RESPONSE TO KETONE 6 182 0.0003602 0.008338
202 REGULATION OF PROTEIN LOCALIZATION 14 950 0.0003623 0.008344
203 REGULATION OF PROTEIN IMPORT 6 183 0.0003709 0.008501
204 POSITIVE REGULATION OF SUBSTRATE ADHESION DEPENDENT CELL SPREADING 3 28 0.0003957 0.008982
205 REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 3 28 0.0003957 0.008982
206 ORGANONITROGEN COMPOUND CATABOLIC PROCESS 8 343 0.0003988 0.009007
207 CELLULAR CATABOLIC PROCESS 17 1322 0.0004028 0.009054
208 REGULATION OF GROWTH 11 633 0.0004178 0.009301
209 HUMORAL IMMUNE RESPONSE 6 187 0.0004161 0.009301
210 AGING 7 264 0.0004349 0.00959
211 LIPID LOCALIZATION 7 264 0.0004349 0.00959
212 HUMORAL IMMUNE RESPONSE MEDIATED BY CIRCULATING IMMUNOGLOBULIN 4 69 0.0004436 0.009736
213 LIPOPROTEIN METABOLIC PROCESS 5 124 0.0004554 0.009949
214 HOMEOSTATIC PROCESS 17 1337 0.0004585 0.009968
NumGOOverlapSizeP ValueAdj. P Value
1 LIPID BINDING 21 657 1.675e-11 1.556e-08
2 COFACTOR BINDING 14 263 7.939e-11 3.688e-08
3 ORGANIC ACID BINDING 12 209 8.213e-10 2.543e-07
4 MONOCARBOXYLIC ACID BINDING 8 65 1.487e-09 3.454e-07
5 OXIDOREDUCTASE ACTIVITY 19 719 4.128e-09 7.67e-07
6 OXIDOREDUCTASE ACTIVITY ACTING ON THE CH OH GROUP OF DONORS NAD OR NADP AS ACCEPTOR 9 113 6.844e-09 1.06e-06
7 OXIDOREDUCTASE ACTIVITY ACTING ON CH OH GROUP OF DONORS 9 134 3.059e-08 4.06e-06
8 HORMONE BINDING 7 65 4.26e-08 4.947e-06
9 ISOPRENOID BINDING 6 40 5.363e-08 5.536e-06
10 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 6 48 1.659e-07 1.541e-05
11 STEROID HORMONE RECEPTOR ACTIVITY 6 59 5.817e-07 4.913e-05
12 IDENTICAL PROTEIN BINDING 21 1209 7.512e-07 5.816e-05
13 TRANSITION METAL ION BINDING 22 1400 2.074e-06 0.0001482
14 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 9 226 2.561e-06 0.0001699
15 COENZYME BINDING 8 179 4.059e-06 0.0002514
16 RETINOIC ACID BINDING 4 23 5.448e-06 0.0003081
17 PROTEIN DIMERIZATION ACTIVITY 19 1149 5.637e-06 0.0003081
18 FATTY ACID BINDING 4 31 1.876e-05 0.000968
19 ENZYME INHIBITOR ACTIVITY 10 378 2.558e-05 0.001251
20 GLUCURONOSYLTRANSFERASE ACTIVITY 4 34 2.732e-05 0.001269
21 OXIDOREDUCTASE ACTIVITY ACTING ON THE ALDEHYDE OR OXO GROUP OF DONORS NAD OR NADP AS ACCEPTOR 4 36 3.443e-05 0.001523
22 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 9 315 3.651e-05 0.001542
23 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 9 328 4.995e-05 0.002017
24 INSULIN LIKE GROWTH FACTOR RECEPTOR BINDING 3 15 5.77e-05 0.002234
25 ENZYME BINDING 22 1737 6.136e-05 0.00228
26 ZINC ION BINDING 17 1155 8.091e-05 0.002891
27 PROTEIN HOMODIMERIZATION ACTIVITY 13 722 8.541e-05 0.002939
28 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 12 629 9.481e-05 0.003037
29 OXIDOREDUCTASE ACTIVITY ACTING ON THE ALDEHYDE OR OXO GROUP OF DONORS 4 46 9.167e-05 0.003037
30 RETINOL DEHYDROGENASE ACTIVITY 3 18 0.0001023 0.003169
31 STEROID BINDING 5 91 0.0001075 0.003223
32 ALDEHYDE DEHYDROGENASE NAD ACTIVITY 3 19 0.0001211 0.003514
33 RECEPTOR BINDING 19 1476 0.0001729 0.004868
34 OXIDOREDUCTASE ACTIVITY ACTING ON THE CH CH GROUP OF DONORS 4 57 0.0002125 0.005806
35 ELECTRON CARRIER ACTIVITY 5 112 0.0002849 0.007562
36 PEPTIDASE INHIBITOR ACTIVITY 6 177 0.0003104 0.008009
37 LYASE ACTIVITY 6 179 0.0003296 0.008276
38 TRANSCRIPTION FACTOR BINDING 10 524 0.0003731 0.00912
39 ENZYME REGULATOR ACTIVITY 14 959 0.0003982 0.009392
40 CELL ADHESION MOLECULE BINDING 6 186 0.0004044 0.009392
NumGOOverlapSizeP ValueAdj. P Value
1 BLOOD MICROPARTICLE 14 143 1.908e-14 1.115e-11
2 VESICLE LUMEN 12 106 2.657e-13 7.758e-11
3 EXTRACELLULAR SPACE 31 1376 1.031e-12 2.008e-10
4 SECRETORY GRANULE LUMEN 10 85 1.908e-11 2.785e-09
5 PLATELET ALPHA GRANULE LUMEN 8 55 3.742e-10 4.371e-08
6 PLATELET ALPHA GRANULE 8 75 4.765e-09 4.638e-07
7 SECRETORY GRANULE 11 352 2.021e-06 0.0001686
8 ENDOPLASMIC RETICULUM 23 1631 7.153e-06 0.0005222
9 SECRETORY VESICLE 11 461 2.567e-05 0.001666
10 PROTEIN LIPID COMPLEX 4 40 5.257e-05 0.00307
11 CYTOPLASMIC VESICLE PART 12 601 6.153e-05 0.003267

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 FoxO_signaling_pathway_hsa04068 9 132 2.683e-08 1.395e-06
2 PI3K_Akt_signaling_pathway_hsa04151 11 352 2.021e-06 5.254e-05
3 AMPK_signaling_pathway_hsa04152 6 121 3.836e-05 0.0006649
4 HIF_1_signaling_pathway_hsa04066 4 100 0.001781 0.02316
5 p53_signaling_pathway_hsa04115 3 68 0.005216 0.05425
6 mTOR_signaling_pathway_hsa04150 4 151 0.007748 0.06715
7 Peroxisome_hsa04146 3 83 0.009048 0.06721
8 Focal_adhesion_hsa04510 4 199 0.01959 0.1267
9 Rap1_signaling_pathway_hsa04015 4 206 0.02192 0.1267
10 Ras_signaling_pathway_hsa04014 4 232 0.03202 0.1665
11 Phospholipase_D_signaling_pathway_hsa04072 3 146 0.03972 0.1878
12 Cellular_senescence_hsa04218 3 160 0.04978 0.1976
13 Jak_STAT_signaling_pathway_hsa04630 3 162 0.05131 0.1976
14 Adherens_junction_hsa04520 2 72 0.05319 0.1976
15 MAPK_signaling_pathway_hsa04010 4 295 0.06618 0.2294
16 ErbB_signaling_pathway_hsa04012 2 85 0.0712 0.2314
17 cAMP_signaling_pathway_hsa04024 3 198 0.08256 0.2525
18 Cell_cycle_hsa04110 2 124 0.1341 0.3668
19 Oocyte_meiosis_hsa04114 2 124 0.1341 0.3668
20 Autophagy_animal_hsa04140 2 128 0.1411 0.3668
21 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.1607 0.3848
22 Cytokine_cytokine_receptor_interaction_hsa04060 3 270 0.1628 0.3848
23 Neuroactive_ligand_receptor_interaction_hsa04080 3 278 0.1729 0.3908
24 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.2051 0.4443
25 Regulation_of_actin_cytoskeleton_hsa04810 2 208 0.2906 0.5597

Quest ID: 2687df45c350a973643e3b11b9d6ab78