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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7a-3p ABCA1 1.42 0 -0.71 0.00276 mirMAP; miRNATAP -0.28 0 NA
2 hsa-let-7a-3p ABCC4 1.42 0 -1.54 1.0E-5 mirMAP -0.19 0.01906 NA
3 hsa-let-7a-3p ABCC9 1.42 0 -2.76 0 mirMAP -0.65 0 NA
4 hsa-let-7a-3p ABCD2 1.42 0 -3.08 0 mirMAP -0.67 0 NA
5 hsa-let-7a-3p ABCD3 1.42 0 0.14 0.52609 MirTarget -0.12 0.02959 NA
6 hsa-let-7a-3p ABI3BP 1.42 0 -4.28 0 miRNATAP -0.98 0 NA
7 hsa-let-7a-3p ABLIM1 1.42 0 -1.72 0 mirMAP -0.15 0.02468 NA
8 hsa-let-7a-3p ADAMTS5 1.42 0 -2.16 0 mirMAP -0.34 1.0E-5 NA
9 hsa-let-7a-3p ADAMTSL3 1.42 0 -5.11 0 MirTarget -1.04 0 NA
10 hsa-let-7a-3p ADCYAP1 1.42 0 -3.51 0 miRNATAP -0.66 0 NA
11 hsa-let-7a-3p ADD3 1.42 0 -0.66 0.00185 mirMAP; miRNATAP -0.14 0.00449 NA
12 hsa-let-7a-3p AFF2 1.42 0 -1.73 0.00201 mirMAP -0.29 0.02983 NA
13 hsa-let-7a-3p AFF3 1.42 0 -5 0 MirTarget -1.07 0 NA
14 hsa-let-7a-3p AKAP11 1.42 0 -0.8 0 mirMAP -0.16 4.0E-5 NA
15 hsa-let-7a-3p AKAP12 1.42 0 -2.95 0 miRNATAP -0.59 0 NA
16 hsa-let-7a-3p AKTIP 1.42 0 -0.35 0.01135 MirTarget -0.14 3.0E-5 NA
17 hsa-let-7a-3p ALDH1L2 1.42 0 -1.12 0.02448 MirTarget -0.24 0.04301 NA
18 hsa-let-7a-3p AMN1 1.42 0 -0.48 0.00493 mirMAP -0.12 0.00228 NA
19 hsa-let-7a-3p AMOT 1.42 0 -1.51 0.00385 mirMAP -0.61 0 NA
20 hsa-let-7a-3p AMOTL1 1.42 0 -1.62 0 mirMAP -0.29 3.0E-5 NA
21 hsa-let-7a-3p AMOTL2 1.42 0 -1.01 0.00015 miRNATAP -0.19 0.00261 NA
22 hsa-let-7a-3p ANKS1B 1.42 0 -3.65 0 miRNATAP -0.78 0 NA
23 hsa-let-7a-3p ANO5 1.42 0 -3.19 0 mirMAP -0.88 0 NA
24 hsa-let-7a-3p ANTXR1 1.42 0 -0.71 0.0159 mirMAP; miRNATAP -0.29 5.0E-5 NA
25 hsa-let-7a-3p ARHGAP20 1.42 0 -3.52 0 MirTarget; miRNATAP -0.72 0 NA
26 hsa-let-7a-3p ARHGAP28 1.42 0 -1.54 0.00053 mirMAP -0.4 0.00021 NA
27 hsa-let-7a-3p ARHGAP29 1.42 0 -0.34 0.31665 mirMAP -0.24 0.00278 NA
28 hsa-let-7a-3p ARHGEF3 1.42 0 -0.76 0 MirTarget -0.16 4.0E-5 NA
29 hsa-let-7a-3p ARID4A 1.42 0 -0.76 0 MirTarget; miRNATAP -0.12 0.00103 NA
30 hsa-let-7a-3p ARID5B 1.42 0 -1.57 0 miRNATAP -0.33 0 NA
31 hsa-let-7a-3p ARSB 1.42 0 -0.58 0.00052 mirMAP -0.14 0.00029 NA
32 hsa-let-7a-3p ART4 1.42 0 -1.65 0.00419 mirMAP -0.63 1.0E-5 NA
33 hsa-let-7a-3p ASAH1 1.42 0 -0.59 0.00556 MirTarget -0.19 0.00013 NA
34 hsa-let-7a-3p ASTN2 1.42 0 -0.88 0.05369 mirMAP -0.38 0.00047 NA
35 hsa-let-7a-3p ATE1 1.42 0 -1.09 3.0E-5 mirMAP -0.16 0.01164 NA
36 hsa-let-7a-3p AXIN2 1.42 0 -1.7 6.0E-5 miRNATAP -0.58 0 NA
37 hsa-let-7a-3p B3GAT2 1.42 0 -1.18 0.00022 mirMAP -0.21 0.00552 NA
38 hsa-let-7a-3p BCAS1 1.42 0 -0.72 0.38851 mirMAP -0.46 0.02063 NA
39 hsa-let-7a-3p BCL6 1.42 0 -0.56 0.00743 miRNATAP -0.21 2.0E-5 NA
40 hsa-let-7a-3p BEND4 1.42 0 -1.97 7.0E-5 mirMAP -0.37 0.00181 NA
41 hsa-let-7a-3p BEND6 1.42 0 -0.8 0.03128 mirMAP -0.19 0.03467 NA
42 hsa-let-7a-3p BEND7 1.42 0 -0.64 0.19325 mirMAP -0.32 0.00616 NA
43 hsa-let-7a-3p BMP3 1.42 0 -0.54 0.56709 MirTarget; mirMAP -0.47 0.03703 NA
44 hsa-let-7a-3p BMPR2 1.42 0 -0.59 4.0E-5 MirTarget; miRNATAP -0.15 1.0E-5 NA
45 hsa-let-7a-3p BNC2 1.42 0 -2.95 0 mirMAP -0.64 0 NA
46 hsa-let-7a-3p BST1 1.42 0 -1.14 0.00705 MirTarget -0.26 0.01072 NA
47 hsa-let-7a-3p BTNL9 1.42 0 -2.01 9.0E-5 MirTarget -0.59 0 NA
48 hsa-let-7a-3p BVES 1.42 0 -2.76 0 mirMAP -0.4 0.00049 NA
49 hsa-let-7a-3p C8orf46 1.42 0 -1.63 0.00027 mirMAP -0.36 0.00098 NA
50 hsa-let-7a-3p CACNA1C 1.42 0 -2.53 0 MirTarget -0.85 0 NA
51 hsa-let-7a-3p CACNA2D1 1.42 0 -3.32 0 mirMAP -0.5 0.00221 NA
52 hsa-let-7a-3p CACNB2 1.42 0 -2.97 0 MirTarget; mirMAP -0.93 0 NA
53 hsa-let-7a-3p CACNG4 1.42 0 1.13 0.16231 MirTarget -0.54 0.00571 NA
54 hsa-let-7a-3p CASD1 1.42 0 -0.65 0.0001 MirTarget; miRNATAP -0.17 1.0E-5 NA
55 hsa-let-7a-3p CCDC141 1.42 0 -2.94 0 mirMAP -0.48 0 NA
56 hsa-let-7a-3p CCDC50 1.42 0 -0.78 0 miRNATAP -0.11 0.0012 NA
57 hsa-let-7a-3p CCND2 1.42 0 -2.43 0 mirMAP -0.44 0 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2
58 hsa-let-7a-3p CCPG1 1.42 0 -1 0 mirMAP -0.15 0.00139 NA
59 hsa-let-7a-3p CD302 1.42 0 -1.68 0 mirMAP -0.23 1.0E-5 NA
60 hsa-let-7a-3p CDC14A 1.42 0 -0.5 0.01927 mirMAP -0.11 0.03893 NA
61 hsa-let-7a-3p CDC14B 1.42 0 -0.81 2.0E-5 miRNATAP -0.1 0.02522 NA
62 hsa-let-7a-3p CDC42EP3 1.42 0 -1.35 0 MirTarget; mirMAP -0.36 0 NA
63 hsa-let-7a-3p CDHR3 1.42 0 -1.17 0.00028 mirMAP -0.16 0.04012 NA
64 hsa-let-7a-3p CDK20 1.42 0 -0.6 0.0413 MirTarget -0.3 2.0E-5 NA
65 hsa-let-7a-3p CELF2 1.42 0 -3.05 0 miRNATAP -0.62 0 NA
66 hsa-let-7a-3p CFL2 1.42 0 -2.62 0 mirMAP -0.45 0 NA
67 hsa-let-7a-3p CHL1 1.42 0 -2.42 0.00043 MirTarget; miRNATAP -0.56 0.0008 NA
68 hsa-let-7a-3p CLIC4 1.42 0 -1.72 0 MirTarget -0.3 0.00011 NA
69 hsa-let-7a-3p CLIP1 1.42 0 -0.85 0 miRNATAP -0.1 0.02017 NA
70 hsa-let-7a-3p CNKSR2 1.42 0 -2.85 0 MirTarget; mirMAP; miRNATAP -0.55 0 NA
71 hsa-let-7a-3p CNR1 1.42 0 -2.44 4.0E-5 mirMAP -0.44 0.00223 NA
72 hsa-let-7a-3p CNTN1 1.42 0 -4.98 0 MirTarget; miRNATAP -0.76 0.00012 NA
73 hsa-let-7a-3p COL13A1 1.42 0 -1.01 0.009 miRNATAP -0.22 0.02042 NA
74 hsa-let-7a-3p COL15A1 1.42 0 -0.94 0.00988 MirTarget -0.39 1.0E-5 NA
75 hsa-let-7a-3p COL1A2 1.42 0 -0.91 0.05362 MirTarget -0.34 0.00237 NA
76 hsa-let-7a-3p COL4A1 1.42 0 0.15 0.58169 miRNATAP -0.21 0.00159 NA
77 hsa-let-7a-3p COL4A4 1.42 0 -2.67 0 mirMAP -0.73 0 NA
78 hsa-let-7a-3p CPEB2 1.42 0 -1.81 0 mirMAP; miRNATAP -0.13 0.02325 NA
79 hsa-let-7a-3p CPEB3 1.42 0 -1.3 0 MirTarget; miRNATAP -0.2 1.0E-5 NA
80 hsa-let-7a-3p CPEB4 1.42 0 -1.56 0 mirMAP; miRNATAP -0.29 0 NA
81 hsa-let-7a-3p CREBL2 1.42 0 -0.7 0 mirMAP -0.12 0.00076 NA
82 hsa-let-7a-3p CRIM1 1.42 0 -0.45 0.0534 MirTarget -0.16 0.00449 NA
83 hsa-let-7a-3p CRTC3 1.42 0 -0.76 0 MirTarget -0.22 0 NA
84 hsa-let-7a-3p CSTF2T 1.42 0 -0.61 0.00221 MirTarget -0.12 0.01691 NA
85 hsa-let-7a-3p CUX2 1.42 0 -1.95 2.0E-5 MirTarget; miRNATAP -0.36 0.00139 NA
86 hsa-let-7a-3p CX3CR1 1.42 0 -1.46 8.0E-5 MirTarget -0.38 2.0E-5 NA
87 hsa-let-7a-3p CYBRD1 1.42 0 -2.55 0 mirMAP -0.38 4.0E-5 NA
88 hsa-let-7a-3p CYP1B1 1.42 0 -2.82 0 mirMAP -0.47 0.00089 NA
89 hsa-let-7a-3p DAB1 1.42 0 -1.92 0.01373 mirMAP -0.96 0 NA
90 hsa-let-7a-3p DACH1 1.42 0 -2.45 0 MirTarget -0.24 0.02345 NA
91 hsa-let-7a-3p DACH2 1.42 0 -0.77 0.28047 mirMAP -0.38 0.02762 NA
92 hsa-let-7a-3p DACT1 1.42 0 -1.78 2.0E-5 MirTarget -0.5 0 NA
93 hsa-let-7a-3p DENND4C 1.42 0 -0.64 0.00049 MirTarget -0.16 0.00038 NA
94 hsa-let-7a-3p DLL4 1.42 0 -0.14 0.54558 miRNATAP -0.2 0.00031 NA
95 hsa-let-7a-3p DMXL1 1.42 0 -0.95 0 mirMAP -0.11 0.0042 NA
96 hsa-let-7a-3p DNAJB5 1.42 0 -2.65 0 miRNATAP -0.37 1.0E-5 NA
97 hsa-let-7a-3p DNALI1 1.42 0 -2.11 4.0E-5 MirTarget; miRNATAP -0.6 0 NA
98 hsa-let-7a-3p DNM3 1.42 0 -1.22 4.0E-5 MirTarget -0.18 0.0114 NA
99 hsa-let-7a-3p DOCK1 1.42 0 -0.68 0.00032 MirTarget; miRNATAP -0.11 0.01618 NA
100 hsa-let-7a-3p DOCK11 1.42 0 -1.8 0 MirTarget; miRNATAP -0.44 0 NA
101 hsa-let-7a-3p DOK6 1.42 0 -3.8 0 mirMAP -0.92 0 NA
102 hsa-let-7a-3p DUSP19 1.42 0 -0.99 1.0E-5 mirMAP -0.23 1.0E-5 NA
103 hsa-let-7a-3p EBF1 1.42 0 -2.89 0 mirMAP; miRNATAP -0.64 0 NA
104 hsa-let-7a-3p EBF3 1.42 0 -2.22 0 MirTarget; miRNATAP -0.43 0 NA
105 hsa-let-7a-3p EDIL3 1.42 0 -1.4 0.00541 MirTarget -0.34 0.00495 NA
106 hsa-let-7a-3p EGFL6 1.42 0 -0.53 0.10258 MirTarget -0.17 0.02941 NA
107 hsa-let-7a-3p EIF4E3 1.42 0 -1.31 0 mirMAP -0.25 1.0E-5 NA
108 hsa-let-7a-3p ELOVL2 1.42 0 -1.4 0.00118 miRNATAP -0.37 0.00035 NA
109 hsa-let-7a-3p EML1 1.42 0 -2.07 0 MirTarget -0.59 0 NA
110 hsa-let-7a-3p ENPP1 1.42 0 -2.1 0 mirMAP -0.47 2.0E-5 NA
111 hsa-let-7a-3p ENPP4 1.42 0 -0.94 0.00706 mirMAP -0.49 0 NA
112 hsa-let-7a-3p ENTPD1 1.42 0 -1.12 0 mirMAP -0.34 0 NA
113 hsa-let-7a-3p EPB41L1 1.42 0 -0.41 0.15237 miRNATAP -0.22 0.00128 NA
114 hsa-let-7a-3p EPHA3 1.42 0 -3.18 0 mirMAP; miRNATAP -0.55 0 NA
115 hsa-let-7a-3p EPHA7 1.42 0 -4.2 0 mirMAP; miRNATAP -0.97 0 NA
116 hsa-let-7a-3p ESR1 1.42 0 -2.87 0 mirMAP -0.38 0.00081 20535543; 21826373 Let 7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancer; Next we performed bioinformatics analysis and found that let-7 miRNA sequences match sequence in the 3'-UTR of estrogen receptor alpha ER-α suggesting ER-α may be a target of let-7 which was further confirmed by a number of experimental assays including luciferase assay protein expression and mRNA expression;let 7 microRNAs induce tamoxifen sensitivity by downregulation of estrogen receptor α signaling in breast cancer
117 hsa-let-7a-3p EVI2A 1.42 0 -1.18 0.00499 MirTarget -0.27 0.00664 NA
118 hsa-let-7a-3p FAM102B 1.42 0 -1.36 0 mirMAP -0.14 0.01409 NA
119 hsa-let-7a-3p FAM117A 1.42 0 -1.06 0 miRNATAP -0.25 0 NA
120 hsa-let-7a-3p FAM160B1 1.42 0 -0.46 0.00084 mirMAP -0.18 0 NA
121 hsa-let-7a-3p FAM171A1 1.42 0 -1.6 4.0E-5 miRNATAP -0.35 0.00016 NA
122 hsa-let-7a-3p FAM19A2 1.42 0 -2.67 0 miRNATAP -0.29 0.00261 NA
123 hsa-let-7a-3p FAM19A5 1.42 0 -0.93 0.03784 MirTarget; miRNATAP -0.51 0 NA
124 hsa-let-7a-3p FAM26E 1.42 0 -1.51 4.0E-5 mirMAP -0.38 2.0E-5 NA
125 hsa-let-7a-3p FAM46A 1.42 0 -1.54 0 mirMAP -0.13 0.02272 NA
126 hsa-let-7a-3p FAM47E 1.42 0 -0.45 0.25689 MirTarget -0.37 0.0001 NA
127 hsa-let-7a-3p FAM63B 1.42 0 -0.55 0.03992 mirMAP -0.14 0.02521 NA
128 hsa-let-7a-3p FAT3 1.42 0 -2.79 0 miRNATAP -0.84 0 NA
129 hsa-let-7a-3p FBN1 1.42 0 -1.82 5.0E-5 mirMAP -0.53 0 NA
130 hsa-let-7a-3p FBXO32 1.42 0 -0.93 0.00122 mirMAP -0.38 0 NA
131 hsa-let-7a-3p FGF13 1.42 0 -2.8 0 MirTarget; miRNATAP -0.48 0 NA
132 hsa-let-7a-3p FGF2 1.42 0 -3.46 0 mirMAP -0.57 0 NA
133 hsa-let-7a-3p FGF7 1.42 0 -3.51 0 MirTarget; miRNATAP -0.87 0 NA
134 hsa-let-7a-3p FGFR2 1.42 0 -1.11 0.01288 miRNATAP -0.4 0.00015 NA
135 hsa-let-7a-3p FIGN 1.42 0 -0.34 0.46881 mirMAP -0.25 0.02499 NA
136 hsa-let-7a-3p FKBP7 1.42 0 -0.88 5.0E-5 mirMAP -0.27 0 NA
137 hsa-let-7a-3p FNIP2 1.42 0 -0.76 0.01045 mirMAP -0.18 0.0132 NA
138 hsa-let-7a-3p FOXO1 1.42 0 -1.06 0 MirTarget; miRNATAP -0.14 0.00213 NA
139 hsa-let-7a-3p FOXP1 1.42 0 -0.87 0 miRNATAP -0.18 6.0E-5 NA
140 hsa-let-7a-3p FOXP2 1.42 0 -3.99 0 MirTarget; mirMAP -0.6 7.0E-5 NA
141 hsa-let-7a-3p FREM2 1.42 0 -0.14 0.88581 MirTarget; mirMAP -0.89 0.00016 NA
142 hsa-let-7a-3p FRMD3 1.42 0 -2.55 0 mirMAP; miRNATAP -0.48 0 NA
143 hsa-let-7a-3p FRMD4A 1.42 0 -0.28 0.24286 miRNATAP -0.12 0.04101 NA
144 hsa-let-7a-3p FSTL1 1.42 0 -1.2 3.0E-5 mirMAP -0.32 0 NA
145 hsa-let-7a-3p FYN 1.42 0 -1.47 0 miRNATAP -0.4 0 NA
146 hsa-let-7a-3p FZD3 1.42 0 -0.31 0.22562 MirTarget; miRNATAP -0.15 0.01617 NA
147 hsa-let-7a-3p FZD4 1.42 0 -0.83 0.00068 mirMAP -0.26 1.0E-5 NA
148 hsa-let-7a-3p GAB1 1.42 0 -0.89 0 mirMAP -0.18 3.0E-5 NA
149 hsa-let-7a-3p GABRB3 1.42 0 -1.66 0.03874 miRNATAP -0.49 0.0108 NA
150 hsa-let-7a-3p GAS1 1.42 0 -2.19 0.00038 miRNATAP -0.56 0.00014 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 96 1672 1.849e-18 8.605e-15
2 REGULATION OF CELL DIFFERENTIATION 86 1492 1.329e-16 2.989e-13
3 REGULATION OF CELL DEVELOPMENT 61 836 1.927e-16 2.989e-13
4 NEUROGENESIS 81 1402 1.078e-15 1.254e-12
5 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 54 750 2.132e-14 1.984e-11
6 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 63 1021 1.454e-13 1.127e-10
7 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 84 1656 4.365e-13 2.901e-10
8 REGULATION OF NEURON DIFFERENTIATION 42 554 3.903e-12 2.27e-09
9 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 73 1395 4.637e-12 2.397e-09
10 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 64 1142 6.51e-12 3.029e-09
11 RESPONSE TO ENDOGENOUS STIMULUS 74 1450 1.068e-11 4.519e-09
12 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 51 801 1.24e-11 4.807e-09
13 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 50 799 3.723e-11 1.333e-08
14 REGULATION OF CELL PROJECTION ORGANIZATION 40 558 7.229e-11 2.349e-08
15 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 57 1008 7.572e-11 2.349e-08
16 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 57 1036 2.156e-10 5.902e-08
17 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 57 1036 2.156e-10 5.902e-08
18 REGULATION OF PHOSPHORUS METABOLIC PROCESS 76 1618 2.713e-10 7.012e-08
19 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 83 1848 3.117e-10 7.634e-08
20 REGULATION OF CELLULAR COMPONENT MOVEMENT 47 771 3.603e-10 8.382e-08
21 BEHAVIOR 37 516 3.835e-10 8.497e-08
22 REGULATION OF PROTEIN MODIFICATION PROCESS 78 1710 5.907e-10 1.249e-07
23 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 54 983 7.179e-10 1.369e-07
24 CARDIOVASCULAR SYSTEM DEVELOPMENT 47 788 7.355e-10 1.369e-07
25 CIRCULATORY SYSTEM DEVELOPMENT 47 788 7.355e-10 1.369e-07
26 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 59 1135 8.925e-10 1.597e-07
27 MORPHOGENESIS OF A BRANCHING STRUCTURE 20 167 9.466e-10 1.631e-07
28 POSITIVE REGULATION OF CELL DIFFERENTIATION 48 823 1.001e-09 1.664e-07
29 TISSUE DEVELOPMENT 71 1518 1.405e-09 2.254e-07
30 POSITIVE REGULATION OF CELL DEVELOPMENT 34 472 1.81e-09 2.808e-07
31 ORGAN MORPHOGENESIS 48 841 2.029e-09 3.045e-07
32 TUBE DEVELOPMENT 37 552 2.445e-09 3.556e-07
33 SINGLE ORGANISM BEHAVIOR 30 384 2.597e-09 3.662e-07
34 NEGATIVE REGULATION OF CELL DIFFERENTIATION 39 609 3.21e-09 4.393e-07
35 CELL DEVELOPMENT 67 1426 3.682e-09 4.894e-07
36 REGULATION OF GTPASE ACTIVITY 41 673 5.268e-09 6.808e-07
37 RESPONSE TO OXYGEN CONTAINING COMPOUND 65 1381 6.101e-09 7.673e-07
38 LOCOMOTION 56 1114 8.26e-09 1.011e-06
39 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 68 1492 9.42e-09 1.124e-06
40 POSITIVE REGULATION OF MOLECULAR FUNCTION 77 1791 1.077e-08 1.193e-06
41 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 61 1275 1.05e-08 1.193e-06
42 REGULATION OF NEURON PROJECTION DEVELOPMENT 30 408 1.053e-08 1.193e-06
43 BLOOD VESSEL MORPHOGENESIS 28 364 1.25e-08 1.353e-06
44 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 31 437 1.377e-08 1.456e-06
45 INTRACELLULAR SIGNAL TRANSDUCTION 70 1572 1.413e-08 1.461e-06
46 VASCULATURE DEVELOPMENT 32 469 2.013e-08 2.036e-06
47 REGULATION OF CELLULAR COMPONENT BIOGENESIS 43 767 2.499e-08 2.474e-06
48 REGULATION OF MAPK CASCADE 39 660 2.894e-08 2.805e-06
49 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 40 689 3.087e-08 2.932e-06
50 CELLULAR RESPONSE TO NITROGEN COMPOUND 33 505 3.394e-08 3.158e-06
51 REGULATION OF SYSTEM PROCESS 33 507 3.728e-08 3.402e-06
52 REGULATION OF HYDROLASE ACTIVITY 61 1327 4.492e-08 4.02e-06
53 TUBE MORPHOGENESIS 25 323 6.779e-08 5.951e-06
54 CENTRAL NERVOUS SYSTEM DEVELOPMENT 45 872 1.306e-07 1.126e-05
55 NEURON DIFFERENTIATION 45 874 1.394e-07 1.18e-05
56 GROWTH 28 410 1.549e-07 1.287e-05
57 HEAD DEVELOPMENT 39 709 1.892e-07 1.544e-05
58 NEGATIVE REGULATION OF CELL COMMUNICATION 55 1192 1.982e-07 1.59e-05
59 POSITIVE REGULATION OF CATALYTIC ACTIVITY 65 1518 2.117e-07 1.669e-05
60 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 15 131 2.19e-07 1.698e-05
61 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 11 67 2.342e-07 1.787e-05
62 RESPONSE TO HORMONE 45 893 2.559e-07 1.921e-05
63 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 31 498 2.615e-07 1.931e-05
64 CELLULAR RESPONSE TO HORMONE STIMULUS 33 552 2.695e-07 1.959e-05
65 MODULATION OF SYNAPTIC TRANSMISSION 23 301 2.867e-07 2.052e-05
66 MUSCLE SYSTEM PROCESS 22 282 3.653e-07 2.575e-05
67 TISSUE MORPHOGENESIS 32 533 3.74e-07 2.597e-05
68 POSITIVE REGULATION OF NEURON DIFFERENTIATION 23 306 3.838e-07 2.626e-05
69 SKELETAL SYSTEM DEVELOPMENT 29 455 3.948e-07 2.662e-05
70 BIOLOGICAL ADHESION 49 1032 4.269e-07 2.837e-05
71 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 13 103 4.545e-07 2.978e-05
72 REGULATION OF OSSIFICATION 17 178 4.824e-07 3.118e-05
73 EPITHELIUM DEVELOPMENT 46 945 4.97e-07 3.168e-05
74 REGULATION OF CELL PROLIFERATION 63 1496 5.948e-07 3.74e-05
75 REGULATION OF TRANSPORT 72 1804 6.358e-07 3.945e-05
76 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 6 16 7.574e-07 4.637e-05
77 REGULATION OF CELL MORPHOGENESIS 32 552 8.052e-07 4.866e-05
78 SYNAPSE ORGANIZATION 15 145 8.229e-07 4.909e-05
79 REGULATION OF EPITHELIAL CELL MIGRATION 16 166 9.254e-07 5.45e-05
80 MORPHOGENESIS OF AN EPITHELIUM 26 400 1.102e-06 6.408e-05
81 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 22 303 1.228e-06 7.055e-05
82 POSITIVE REGULATION OF KINASE ACTIVITY 29 482 1.276e-06 7.242e-05
83 RESPONSE TO ORGANIC CYCLIC COMPOUND 44 917 1.312e-06 7.353e-05
84 REGULATION OF ENDOTHELIAL CELL MIGRATION 13 114 1.476e-06 8.079e-05
85 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 38 740 1.471e-06 8.079e-05
86 REGULATION OF CELL DEATH 61 1472 1.561e-06 8.447e-05
87 CELL PROJECTION ORGANIZATION 43 902 2.061e-06 0.0001102
88 POSITIVE REGULATION OF CELL PROLIFERATION 40 814 2.291e-06 0.0001212
89 POSITIVE REGULATION OF GENE EXPRESSION 68 1733 2.486e-06 0.00013
90 POSITIVE REGULATION OF LOCOMOTION 26 420 2.714e-06 0.0001403
91 REGULATION OF MAP KINASE ACTIVITY 22 319 2.864e-06 0.0001464
92 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 69 1784 3.416e-06 0.0001728
93 RESPONSE TO NITROGEN COMPOUND 41 859 3.5e-06 0.0001751
94 COGNITION 19 251 3.567e-06 0.0001766
95 REGULATION OF FAT CELL DIFFERENTIATION 12 106 4.034e-06 0.0001976
96 CELL MOTILITY 40 835 4.243e-06 0.0002035
97 LOCALIZATION OF CELL 40 835 4.243e-06 0.0002035
98 CELLULAR COMPONENT MORPHOGENESIS 42 900 4.633e-06 0.00022
99 MUSCLE CONTRACTION 18 233 4.84e-06 0.0002275
100 NEURON PROJECTION DEVELOPMENT 30 545 5.049e-06 0.0002349
101 REGULATION OF LIPID METABOLIC PROCESS 20 282 5.328e-06 0.0002431
102 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 56 1360 5.321e-06 0.0002431
103 HEART MORPHOGENESIS 17 212 5.392e-06 0.0002436
104 POSITIVE REGULATION OF CELL COMMUNICATION 61 1532 5.591e-06 0.0002501
105 PROTEIN PHOSPHORYLATION 43 944 6.497e-06 0.0002879
106 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 22 337 6.919e-06 0.0003037
107 POSITIVE REGULATION OF MAPK CASCADE 27 470 6.985e-06 0.0003038
108 POSITIVE REGULATION OF RESPONSE TO STIMULUS 72 1929 7.079e-06 0.000305
109 REGULATION OF OSTEOBLAST DIFFERENTIATION 12 112 7.184e-06 0.0003067
110 REGULATION OF DEVELOPMENTAL GROWTH 20 289 7.679e-06 0.0003248
111 REGULATION OF ORGAN MORPHOGENESIS 18 242 8.187e-06 0.0003432
112 RESPIRATORY SYSTEM DEVELOPMENT 16 197 8.645e-06 0.0003592
113 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 49 1152 9.261e-06 0.0003813
114 BONE DEVELOPMENT 14 156 1.015e-05 0.0004142
115 REGULATION OF BLOOD CIRCULATION 20 295 1.04e-05 0.0004208
116 REGULATION OF KINASE ACTIVITY 37 776 1.093e-05 0.0004383
117 CELLULAR RESPONSE TO LIPID 26 457 1.224e-05 0.0004712
118 POSITIVE REGULATION OF HYDROLASE ACTIVITY 41 905 1.224e-05 0.0004712
119 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 28 513 1.222e-05 0.0004712
120 RHYTHMIC PROCESS 20 298 1.206e-05 0.0004712
121 REGULATION OF CELL ADHESION 32 629 1.225e-05 0.0004712
122 SECRETION BY CELL 27 486 1.277e-05 0.0004792
123 NEGATIVE REGULATION OF TRANSPORT 26 458 1.271e-05 0.0004792
124 UROGENITAL SYSTEM DEVELOPMENT 20 299 1.267e-05 0.0004792
125 REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 8 50 1.292e-05 0.0004809
126 MUSCLE STRUCTURE DEVELOPMENT 25 432 1.35e-05 0.0004984
127 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 22 352 1.371e-05 0.0005022
128 EPITHELIAL TUBE BRANCHING INVOLVED IN LUNG MORPHOGENESIS 6 25 1.414e-05 0.000514
129 MUSCLE ORGAN DEVELOPMENT 19 277 1.465e-05 0.0005285
130 ACTIVATION OF PROTEIN KINASE ACTIVITY 19 279 1.621e-05 0.0005801
131 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 25 437 1.639e-05 0.0005804
132 SENSORY ORGAN DEVELOPMENT 27 493 1.646e-05 0.0005804
133 HEART DEVELOPMENT 26 466 1.716e-05 0.0006004
134 RESPONSE TO LIPID 40 888 1.789e-05 0.0006212
135 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 67 1805 1.852e-05 0.0006378
136 REGULATION OF RESPONSE TO WOUNDING 24 413 1.874e-05 0.0006378
137 DEVELOPMENTAL GROWTH 21 333 1.878e-05 0.0006378
138 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 26 470 1.988e-05 0.0006702
139 NEGATIVE REGULATION OF GENE EXPRESSION 58 1493 2.009e-05 0.0006726
140 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 42 957 2.029e-05 0.0006742
141 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 7 39 2.079e-05 0.0006811
142 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 31 616 2.07e-05 0.0006811
143 RESPONSE TO ALCOHOL 22 362 2.111e-05 0.000687
144 SECRETION 30 588 2.178e-05 0.0006994
145 REGULATION OF EPITHELIAL CELL PROLIFERATION 19 285 2.179e-05 0.0006994
146 HIPPO SIGNALING 6 27 2.276e-05 0.0007206
147 AXIS ELONGATION 6 27 2.276e-05 0.0007206
148 RESPONSE TO GROWTH FACTOR 26 475 2.382e-05 0.0007488
149 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 18 262 2.4e-05 0.0007494
150 SYSTEM PROCESS 66 1785 2.437e-05 0.000756
151 REGULATION OF ION TRANSPORT 30 592 2.473e-05 0.0007621
152 BRANCH ELONGATION OF AN EPITHELIUM 5 17 2.589e-05 0.0007924
153 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 19 289 2.642e-05 0.0008035
154 REGULATION OF POSTSYNAPTIC MEMBRANE POTENTIAL 8 55 2.66e-05 0.0008036
155 NEURON DEVELOPMENT 33 687 2.853e-05 0.0008564
156 EMBRYONIC MORPHOGENESIS 28 539 2.98e-05 0.0008887
157 OUTFLOW TRACT MORPHOGENESIS 8 56 3.043e-05 0.000902
158 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 58 1517 3.171e-05 0.0009337
159 ANGIOGENESIS 19 293 3.191e-05 0.0009337
160 REGULATION OF CELL SUBSTRATE ADHESION 14 173 3.263e-05 0.0009466
161 REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 9 73 3.275e-05 0.0009466
162 POSITIVE REGULATION OF GLUCOSE TRANSPORT 7 42 3.443e-05 0.0009889
163 REGULATION OF HEART CONTRACTION 16 221 3.596e-05 0.001027
164 CELLULAR RESPONSE TO ACID CHEMICAL 14 175 3.706e-05 0.00105
165 REGULATION OF TRANSPORTER ACTIVITY 15 198 3.725e-05 0.00105
166 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 23 404 3.84e-05 0.001076
167 REGULATION OF STEM CELL DIFFERENTIATION 11 113 4.256e-05 0.001186
168 TAXIS 25 464 4.413e-05 0.001222
169 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 25 465 4.57e-05 0.001258
170 NEGATIVE REGULATION OF CELL PROLIFERATION 31 643 4.662e-05 0.001276
171 NEGATIVE REGULATION OF CELL DEVELOPMENT 19 303 5.031e-05 0.001369
172 REGULATION OF GLUCOSE IMPORT 8 60 5.074e-05 0.001373
173 LUNG MORPHOGENESIS 7 45 5.469e-05 0.001463
174 VENTRICULAR CARDIAC MUSCLE TISSUE DEVELOPMENT 7 45 5.469e-05 0.001463
175 MEMBRANE DEPOLARIZATION 8 61 5.729e-05 0.001523
176 NEGATIVE REGULATION OF CELL DEATH 38 872 5.918e-05 0.001565
177 POSITIVE REGULATION OF MAP KINASE ACTIVITY 15 207 6.205e-05 0.001622
178 BONE MORPHOGENESIS 9 79 6.177e-05 0.001622
179 MEMORY 10 98 6.325e-05 0.001644
180 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 16 232 6.441e-05 0.001649
181 CARDIAC VENTRICLE MORPHOGENESIS 8 62 6.452e-05 0.001649
182 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 16 232 6.441e-05 0.001649
183 CARDIAC MUSCLE TISSUE DEVELOPMENT 12 140 6.793e-05 0.001727
184 REGULATION OF MUSCLE ADAPTATION 8 63 7.249e-05 0.001833
185 ACTIN FILAMENT BASED PROCESS 24 450 7.329e-05 0.001843
186 CIRCULATORY SYSTEM PROCESS 21 366 7.42e-05 0.001847
187 REGULATION OF ACTIN FILAMENT BASED PROCESS 19 312 7.438e-05 0.001847
188 NEGATIVE REGULATION OF PHOSPHORYLATION 23 422 7.463e-05 0.001847
189 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 10 100 7.517e-05 0.001851
190 REGULATION OF MEMBRANE POTENTIAL 20 343 8.805e-05 0.002156
191 RESPONSE TO ACID CHEMICAL 19 319 9.966e-05 0.002428
192 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 15 216 0.0001003 0.00243
193 PALATE DEVELOPMENT 9 85 0.00011 0.002637
194 RHO PROTEIN SIGNAL TRANSDUCTION 7 50 0.0001095 0.002637
195 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 22 406 0.0001158 0.002749
196 EMBRYONIC ORGAN DEVELOPMENT 22 406 0.0001158 0.002749
197 NEGATIVE REGULATION OF NEURON DEATH 13 171 0.0001173 0.002771
198 POSITIVE REGULATION OF FAT CELL DIFFERENTIATION 7 51 0.0001245 0.002896
199 REGULATION OF CELL JUNCTION ASSEMBLY 8 68 0.0001256 0.002896
200 REPRODUCTIVE SYSTEM DEVELOPMENT 22 408 0.0001243 0.002896
201 ORGAN GROWTH 8 68 0.0001256 0.002896
202 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 41 1004 0.0001257 0.002896
203 NEUROMUSCULAR JUNCTION DEVELOPMENT 6 36 0.0001266 0.002901
204 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 11 128 0.0001325 0.003022
205 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 37 876 0.0001394 0.003163
206 CELLULAR RESPONSE TO PEPTIDE 17 274 0.0001408 0.003181
207 ESTABLISHMENT OF CELL POLARITY 9 88 0.0001439 0.003235
208 MUSCLE TISSUE DEVELOPMENT 17 275 0.0001471 0.003291
209 REGULATION OF TRANSFERASE ACTIVITY 39 946 0.0001518 0.00338
210 NEURAL PRECURSOR CELL PROLIFERATION 8 70 0.0001544 0.003405
211 MUSCLE ORGAN MORPHOGENESIS 8 70 0.0001544 0.003405
212 RESPONSE TO WOUNDING 27 563 0.0001563 0.00343
213 POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY 7 53 0.0001595 0.003485
214 SKELETAL SYSTEM MORPHOGENESIS 14 201 0.0001644 0.003576
215 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 17 278 0.0001675 0.003608
216 NEURON MIGRATION 10 110 0.0001674 0.003608
217 POSITIVE REGULATION OF ORGAN GROWTH 6 38 0.0001728 0.003705
218 CELL FATE COMMITMENT 15 227 0.0001737 0.003707
219 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 11 133 0.0001861 0.003954
220 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 15 229 0.0001911 0.004006
221 REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 5 25 0.000192 0.004006
222 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 12 156 0.0001907 0.004006
223 POSITIVE REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 5 25 0.000192 0.004006
224 REGULATION OF GROWTH 29 633 0.0001958 0.004067
225 SPECIFICATION OF ORGAN IDENTITY 4 14 0.0001993 0.004072
226 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 26 541 0.0001995 0.004072
227 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 4 14 0.0001993 0.004072
228 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 26 541 0.0001995 0.004072
229 REGULATION OF PHOSPHOLIPASE C ACTIVITY 6 39 0.0002004 0.004072
230 EXOCYTOSIS 18 310 0.0002067 0.004181
231 POSITIVE REGULATION OF CELL DEATH 28 605 0.0002134 0.004298
232 REGULATION OF DENDRITIC SPINE DEVELOPMENT 7 56 0.0002267 0.004548
233 REGULATION OF TRANSMEMBRANE TRANSPORT 22 426 0.0002286 0.004565
234 CELL CELL ADHESION 28 608 0.0002313 0.00458
235 REGULATION OF VASCULATURE DEVELOPMENT 15 233 0.0002306 0.00458
236 CELL PROLIFERATION 30 672 0.0002374 0.004681
237 CELLULAR RESPONSE TO ALCOHOL 10 115 0.0002412 0.004719
238 ACTIVATION OF MAPK ACTIVITY 11 137 0.0002414 0.004719
239 SINGLE ORGANISM CELL ADHESION 23 459 0.0002558 0.00498
240 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 11 138 0.0002571 0.004985
241 FEMALE SEX DIFFERENTIATION 10 116 0.0002589 0.004998
242 CYTOSKELETON ORGANIZATION 35 838 0.0002606 0.00501
243 RESPONSE TO STIMULUS INVOLVED IN REGULATION OF MUSCLE ADAPTATION 4 15 0.000267 0.005113
244 CHEMICAL HOMEOSTASIS 36 874 0.0002774 0.005291
245 POSITIVE REGULATION OF HEART GROWTH 5 27 0.0002813 0.005321
246 REGULATION OF ASTROCYTE DIFFERENTIATION 5 27 0.0002813 0.005321
247 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 10 118 0.0002974 0.005603
248 REGULATION OF RESPONSE TO STRESS 53 1468 0.0002993 0.005616
249 NEGATIVE REGULATION OF GTPASE ACTIVITY 6 42 0.0003047 0.005694
250 SEX DIFFERENTIATION 16 266 0.0003109 0.005763
251 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 11 141 0.0003098 0.005763
252 RESPONSE TO STEROID HORMONE 24 497 0.0003249 0.006
253 STEM CELL PROLIFERATION 7 60 0.00035 0.006386
254 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 7 60 0.00035 0.006386
255 RAS PROTEIN SIGNAL TRANSDUCTION 11 143 0.0003498 0.006386
256 REGULATION OF JAK STAT CASCADE 11 144 0.0003714 0.006672
257 RESPONSE TO EXTRACELLULAR STIMULUS 22 441 0.0003681 0.006672
258 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 11 144 0.0003714 0.006672
259 REGULATION OF STAT CASCADE 11 144 0.0003714 0.006672
260 REGULATION OF GLUCOSE TRANSPORT 9 100 0.0003796 0.006793
261 LEUKOCYTE ACTIVATION 21 414 0.0003999 0.007022
262 APPENDAGE DEVELOPMENT 12 169 0.0003987 0.007022
263 CARDIAC MUSCLE CELL CONTRACTION 5 29 0.000399 0.007022
264 LIMB DEVELOPMENT 12 169 0.0003987 0.007022
265 NEUROBLAST PROLIFERATION 5 29 0.000399 0.007022
266 CELLULAR RESPONSE TO INSULIN STIMULUS 11 146 0.0004178 0.007254
267 FOREBRAIN DEVELOPMENT 19 357 0.0004165 0.007254
268 MULTICELLULAR ORGANISMAL SIGNALING 10 123 0.0004152 0.007254
269 EMBRYO DEVELOPMENT 36 894 0.0004235 0.007325
270 REGULATION OF MUSCLE SYSTEM PROCESS 13 195 0.0004257 0.007337
271 RESPONSE TO EXTERNAL STIMULUS 62 1821 0.0004328 0.007431
272 INOSITOL LIPID MEDIATED SIGNALING 10 124 0.0004429 0.007576
273 REGULATION OF ENERGY HOMEOSTASIS 4 17 0.0004495 0.007605
274 REGULATION OF PROTEIN KINASE A SIGNALING 4 17 0.0004495 0.007605
275 SMOOTH MUSCLE CONTRACTION 6 45 0.0004474 0.007605
276 REGULATION OF NEUROTRANSMITTER RECEPTOR ACTIVITY 5 30 0.0004702 0.007898
277 CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 5 30 0.0004702 0.007898
278 REGULATED EXOCYTOSIS 14 224 0.0004973 0.008323
279 CARDIAC CHAMBER MORPHOGENESIS 9 104 0.0005073 0.008461
280 REGULATION OF PHOSPHOLIPASE ACTIVITY 7 64 0.0005219 0.008672
281 REGULATION OF NEURON DEATH 15 252 0.0005296 0.008769
282 POSITIVE REGULATION OF OSSIFICATION 8 84 0.0005448 0.00899
283 MACROPHAGE ACTIVATION 5 31 0.0005505 0.009051
284 NEGATIVE REGULATION OF MOLECULAR FUNCTION 41 1079 0.0005529 0.009059
285 POSITIVE REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 4 18 0.0005678 0.009271
286 REGULATION OF BEHAVIOR 7 65 0.0005739 0.009336
287 CARDIAC VENTRICLE DEVELOPMENT 9 106 0.0005834 0.009458
288 EPHRIN RECEPTOR SIGNALING PATHWAY 8 85 0.00059 0.009532
289 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 19 368 0.0006027 0.009704
290 REGULATION OF REPRODUCTIVE PROCESS 10 129 0.0006053 0.009713
291 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 11 153 0.0006206 0.009924
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 11 81 1.673e-06 0.0005181
2 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 10 64 1.336e-06 0.0005181
3 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 19 228 8.519e-07 0.0005181
4 CYTOSKELETAL PROTEIN BINDING 40 819 2.66e-06 0.0006058
5 MOLECULAR FUNCTION REGULATOR 56 1353 4.565e-06 0.0006058
6 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 22 328 4.491e-06 0.0006058
7 GROWTH FACTOR BINDING 13 123 3.493e-06 0.0006058
8 ENZYME BINDING 67 1737 5.305e-06 0.000616
9 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 51 1199 5.992e-06 0.0006185
10 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 20 303 1.537e-05 0.001428
11 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 31 629 3.083e-05 0.002604
12 TRANSCRIPTION COACTIVATOR BINDING 4 11 6.926e-05 0.005362
13 MACROMOLECULAR COMPLEX BINDING 53 1399 9.072e-05 0.006483
14 PROTEIN TYROSINE KINASE ACTIVITY 13 176 0.0001566 0.009697
15 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 70 0.0001544 0.009697
16 SIGNAL TRANSDUCER ACTIVITY 61 1731 0.0001959 0.0099
17 CYTOKINE BINDING 9 92 0.0002025 0.0099
18 ACTIN BINDING 21 393 0.0001994 0.0099
19 HEPARIN BINDING 12 157 0.0002025 0.0099
NumGOOverlapSizeP ValueAdj. P Value
1 SYNAPSE 52 754 3.655e-13 2.135e-10
2 EXCITATORY SYNAPSE 24 197 1.349e-11 3.938e-09
3 POSTSYNAPSE 31 378 4.285e-10 4.386e-08
4 NEURON PROJECTION 53 942 4.506e-10 4.386e-08
5 CELL PROJECTION 81 1786 3.371e-10 4.386e-08
6 SYNAPSE PART 41 610 2.943e-10 4.386e-08
7 NEURON PART 61 1265 7.84e-09 6.541e-07
8 SOMATODENDRITIC COMPARTMENT 38 650 5.804e-08 4.237e-06
9 MEMBRANE REGION 50 1134 2.758e-06 0.000179
10 PLASMA MEMBRANE REGION 41 929 2.248e-05 0.001313
11 DENDRITE 25 451 2.772e-05 0.001472
12 FILOPODIUM 10 94 4.417e-05 0.002057
13 CYTOSKELETON 70 1967 4.578e-05 0.002057
14 ACTIN BASED CELL PROJECTION 14 181 5.366e-05 0.002238
15 CELL JUNCTION 46 1151 8.013e-05 0.002942
16 CYTOPLASMIC VESICLE PART 29 601 8.06e-05 0.002942
17 CATION CHANNEL COMPLEX 13 167 9.232e-05 0.003172
18 NEURONAL POSTSYNAPTIC DENSITY 7 53 0.0001595 0.004904
19 CELL PROJECTION PART 39 946 0.0001518 0.004904
20 PRESYNAPSE 17 283 0.0002069 0.006042
21 VOLTAGE GATED CALCIUM CHANNEL COMPLEX 6 40 0.0002314 0.006436
22 TRANSPORTER COMPLEX 18 321 0.0003157 0.00838

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 16 199 9.823e-06 0.0003496
2 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 13 139 1.344e-05 0.0003496
3 Tight_junction_hsa04530 14 170 2.686e-05 0.0003874
4 MAPK_signaling_pathway_hsa04010 19 295 3.501e-05 0.0003874
5 cAMP_signaling_pathway_hsa04024 15 198 3.725e-05 0.0003874
6 Rap1_signaling_pathway_hsa04015 14 206 0.0002124 0.00184
7 cGMP_PKG_signaling_pathway_hsa04022 12 163 0.0002866 0.002129
8 Hippo_signaling_pathway_hsa04390 11 154 0.0006554 0.003767
9 Ras_signaling_pathway_hsa04014 14 232 0.0007032 0.003767
10 FoxO_signaling_pathway_hsa04068 10 132 0.0007245 0.003767
11 Regulation_of_actin_cytoskeleton_hsa04810 12 208 0.00241 0.0113
12 TGF_beta_signaling_pathway_hsa04350 7 84 0.002609 0.0113
13 ABC_transporters_hsa02010 5 45 0.003072 0.01229
14 Apelin_signaling_pathway_hsa04371 9 137 0.003499 0.0129
15 Hedgehog_signaling_pathway_hsa04340 5 47 0.003721 0.0129
16 Adherens_junction_hsa04520 6 72 0.005205 0.01624
17 Wnt_signaling_pathway_hsa04310 9 146 0.005309 0.01624
18 ECM_receptor_interaction_hsa04512 6 82 0.009708 0.02805
19 PI3K_Akt_signaling_pathway_hsa04151 15 352 0.01234 0.03378
20 Cell_adhesion_molecules_.CAMs._hsa04514 8 145 0.01561 0.04014
21 Phospholipase_D_signaling_pathway_hsa04072 8 146 0.01621 0.04014
22 Cytokine_cytokine_receptor_interaction_hsa04060 12 270 0.01771 0.04186
23 Sphingolipid_signaling_pathway_hsa04071 6 118 0.04755 0.1075
24 mTOR_signaling_pathway_hsa04150 7 151 0.05126 0.1093
25 AMPK_signaling_pathway_hsa04152 6 121 0.05255 0.1093
26 Oocyte_meiosis_hsa04114 6 124 0.05786 0.1157
27 p53_signaling_pathway_hsa04115 4 68 0.06398 0.1232
28 Jak_STAT_signaling_pathway_hsa04630 7 162 0.0693 0.1287
29 Calcium_signaling_pathway_hsa04020 7 182 0.1107 0.1984
30 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.1346 0.2332
31 Neuroactive_ligand_receptor_interaction_hsa04080 9 278 0.1658 0.2781
32 Endocytosis_hsa04144 8 244 0.1755 0.2852
33 TNF_signaling_pathway_hsa04668 4 108 0.2179 0.3433
34 Peroxisome_hsa04146 3 83 0.2791 0.4266
35 Notch_signaling_pathway_hsa04330 2 48 0.2877 0.4266
36 Cell_cycle_hsa04110 4 124 0.2954 0.4266
37 Gap_junction_hsa04540 3 88 0.3094 0.4348
38 Cellular_senescence_hsa04218 4 160 0.4746 0.6494
39 Lysosome_hsa04142 3 123 0.5149 0.6865
40 Autophagy_animal_hsa04140 3 128 0.5417 0.7042
41 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.6253 0.7898
42 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.6477 0.7898
43 HIF_1_signaling_pathway_hsa04066 2 100 0.6531 0.7898

Quest ID: 275cb91291e66697b51fcdef5c1f6ab7