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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-140-5p A2ML1 -0.41 0.00014 -1.64 0.00028 miRanda -0.52 0.00465 NA
2 hsa-miR-140-5p AACS -0.41 0.00014 -0.28 0.00346 miRanda -0.14 0.00031 NA
3 hsa-miR-140-5p AARS -0.41 0.00014 0.5 0 miRanda -0.1 0.00221 NA
4 hsa-miR-140-5p ABCA13 -0.41 0.00014 0.72 0.08476 miRanda -0.42 0.01163 NA
5 hsa-miR-140-5p ABCC2 -0.41 0.00014 0.93 0.00027 miRanda -0.37 0.0003 NA
6 hsa-miR-140-5p ABLIM1 -0.41 0.00014 -1.46 0 PITA; miRanda -0.16 0.02118 NA
7 hsa-miR-140-5p ACACA -0.41 0.00014 0.15 0.11783 miRanda -0.13 0.00063 NA
8 hsa-miR-140-5p ADAM10 -0.41 0.00014 0.48 0.00248 MirTarget; PITA; miRanda -0.22 0.0005 NA
9 hsa-miR-140-5p ADAM9 -0.41 0.00014 0.33 0.01532 PITA; miRanda; miRNATAP -0.14 0.0104 NA
10 hsa-miR-140-5p AFAP1L1 -0.41 0.00014 0.69 0.0001 miRanda -0.17 0.01982 NA
11 hsa-miR-140-5p AGAP1 -0.41 0.00014 -0.34 0.00122 miRanda -0.12 0.00706 NA
12 hsa-miR-140-5p AMACR -0.41 0.00014 -0.4 0.00406 miRanda -0.24 2.0E-5 NA
13 hsa-miR-140-5p ANO6 -0.41 0.00014 0.26 0.02396 miRanda -0.12 0.01055 NA
14 hsa-miR-140-5p ARAP2 -0.41 0.00014 -0.12 0.4455 miRanda -0.25 4.0E-5 NA
15 hsa-miR-140-5p ARHGAP32 -0.41 0.00014 -0.97 0 miRanda -0.2 0.0023 NA
16 hsa-miR-140-5p ARHGEF4 -0.41 0.00014 0.35 0.06632 miRanda -0.44 0 NA
17 hsa-miR-140-5p ASCC3 -0.41 0.00014 0.14 0.20099 miRanda -0.14 0.00128 NA
18 hsa-miR-140-5p ASXL2 -0.41 0.00014 -0.29 0.17368 mirMAP -0.18 0.03355 NA
19 hsa-miR-140-5p ATP11B -0.41 0.00014 0.16 0.21286 miRanda -0.29 0 NA
20 hsa-miR-140-5p ATP2C1 -0.41 0.00014 0.72 0 miRanda -0.15 5.0E-5 NA
21 hsa-miR-140-5p ATP6V1E2 -0.41 0.00014 0.39 0.00296 miRanda -0.14 0.00762 NA
22 hsa-miR-140-5p BACH1 -0.41 0.00014 0.02 0.88442 MirTarget; PITA; miRanda; miRNATAP -0.16 0.00221 NA
23 hsa-miR-140-5p BAG4 -0.41 0.00014 0.1 0.55198 miRanda -0.13 0.0497 NA
24 hsa-miR-140-5p BAG5 -0.41 0.00014 -0.33 0 miRanda -0.16 0 NA
25 hsa-miR-140-5p BCL7A -0.41 0.00014 0.38 3.0E-5 miRanda -0.13 0.00053 NA
26 hsa-miR-140-5p BCR -0.41 0.00014 0.12 0.19238 miRanda -0.12 0.00153 NA
27 hsa-miR-140-5p BLZF1 -0.41 0.00014 -0.24 0.02094 miRanda -0.11 0.00834 NA
28 hsa-miR-140-5p BMP1 -0.41 0.00014 1.72 0 miRanda -0.16 0.00803 NA
29 hsa-miR-140-5p BMP2 -0.41 0.00014 0.81 0.0004 PITA; miRanda; miRNATAP -0.21 0.02483 NA
30 hsa-miR-140-5p BTBD7 -0.41 0.00014 -0 0.98244 PITA -0.21 0 NA
31 hsa-miR-140-5p CALB1 -0.41 0.00014 4.4 0 miRanda -1.07 3.0E-5 NA
32 hsa-miR-140-5p CALU -0.41 0.00014 0.94 0 PITA; miRanda -0.12 0.02062 NA
33 hsa-miR-140-5p CAND1 -0.41 0.00014 0.35 0.00016 PITA; miRanda -0.11 0.00356 NA
34 hsa-miR-140-5p CARD10 -0.41 0.00014 0.62 0.0007 miRanda -0.18 0.01651 NA
35 hsa-miR-140-5p CASK -0.41 0.00014 0.76 0 miRNATAP -0.23 0 NA
36 hsa-miR-140-5p CCNYL1 -0.41 0.00014 -0.1 0.38945 MirTarget; miRanda -0.14 0.00524 NA
37 hsa-miR-140-5p CD276 -0.41 0.00014 1.85 0 miRanda -0.12 0.04805 NA
38 hsa-miR-140-5p CD58 -0.41 0.00014 0.28 0.00377 miRanda -0.14 0.0003 NA
39 hsa-miR-140-5p CDK12 -0.41 0.00014 0.31 0.00076 miRanda -0.16 2.0E-5 NA
40 hsa-miR-140-5p CDKL5 -0.41 0.00014 -0.94 0.00078 miRanda -0.27 0.01743 NA
41 hsa-miR-140-5p CDYL -0.41 0.00014 0.03 0.66438 PITA; miRanda -0.15 0 NA
42 hsa-miR-140-5p CEBPA -0.41 0.00014 -0.33 0.04895 miRanda -0.14 0.03691 NA
43 hsa-miR-140-5p CHD6 -0.41 0.00014 0.04 0.72918 miRanda -0.12 0.01276 NA
44 hsa-miR-140-5p CHD8 -0.41 0.00014 0.1 0.23186 miRanda -0.11 0.00071 NA
45 hsa-miR-140-5p CKAP2 -0.41 0.00014 0.96 0 miRanda -0.13 0.00586 NA
46 hsa-miR-140-5p CKMT1B -0.41 0.00014 -0.8 0.00072 miRanda -0.21 0.03079 NA
47 hsa-miR-140-5p CLDND1 -0.41 0.00014 0.32 0.00213 miRanda -0.14 0.00081 NA
48 hsa-miR-140-5p CMTM4 -0.41 0.00014 -0.25 0.03886 miRanda -0.13 0.00847 NA
49 hsa-miR-140-5p CNTN1 -0.41 0.00014 0.3 0.48081 PITA; miRanda -0.5 0.00358 NA
50 hsa-miR-140-5p COL17A1 -0.41 0.00014 0.96 0.00225 PITA; miRanda -0.29 0.02509 NA
51 hsa-miR-140-5p COL4A2 -0.41 0.00014 2.59 0 miRanda -0.18 0.03148 NA
52 hsa-miR-140-5p CPNE3 -0.41 0.00014 -0.38 9.0E-5 miRanda -0.12 0.00236 NA
53 hsa-miR-140-5p CPSF2 -0.41 0.00014 0.17 0.02059 miRanda -0.15 0 NA
54 hsa-miR-140-5p CREB1 -0.41 0.00014 0.08 0.21015 miRanda -0.11 3.0E-5 NA
55 hsa-miR-140-5p CREG2 -0.41 0.00014 2.45 0 miRanda -0.77 0 NA
56 hsa-miR-140-5p CRKL -0.41 0.00014 0.53 0 MirTarget; miRanda -0.15 0.00018 NA
57 hsa-miR-140-5p CXADR -0.41 0.00014 -0.32 0.17503 miRanda -0.41 2.0E-5 NA
58 hsa-miR-140-5p CYP27C1 -0.41 0.00014 2.04 0 miRanda -0.38 0.00397 NA
59 hsa-miR-140-5p DAAM1 -0.41 0.00014 -0.37 0.02951 miRanda -0.35 0 NA
60 hsa-miR-140-5p DDX52 -0.41 0.00014 0.1 0.14362 miRanda -0.1 0.00031 NA
61 hsa-miR-140-5p DDX60L -0.41 0.00014 1.45 0 miRanda -0.16 0.04307 NA
62 hsa-miR-140-5p DHX36 -0.41 0.00014 0.51 0 miRanda -0.17 1.0E-5 NA
63 hsa-miR-140-5p DICER1 -0.41 0.00014 -0.21 0.05432 PITA; miRanda -0.17 0.00014 NA
64 hsa-miR-140-5p DLST -0.41 0.00014 -0.15 0.02964 miRanda -0.11 0.0002 NA
65 hsa-miR-140-5p DLX4 -0.41 0.00014 1.21 0 miRanda -0.26 0.00941 NA
66 hsa-miR-140-5p DLX6 -0.41 0.00014 3.14 0 miRanda -0.48 0.00112 NA
67 hsa-miR-140-5p DNMBP -0.41 0.00014 -0.03 0.76253 miRanda -0.11 0.01975 NA
68 hsa-miR-140-5p DNMT3B -0.41 0.00014 2.16 0 miRanda -0.24 0.00323 NA
69 hsa-miR-140-5p DST -0.41 0.00014 0.14 0.39273 mirMAP -0.17 0.01483 NA
70 hsa-miR-140-5p DYNLT3 -0.41 0.00014 -0.61 0.00025 miRanda -0.24 0.00037 NA
71 hsa-miR-140-5p ECT2 -0.41 0.00014 1.55 0 miRanda -0.18 0.00347 NA
72 hsa-miR-140-5p EFCAB1 -0.41 0.00014 -0.15 0.64917 miRanda -0.28 0.03108 NA
73 hsa-miR-140-5p EFNA4 -0.41 0.00014 0.32 0.00241 PITA; miRanda -0.1 0.01669 NA
74 hsa-miR-140-5p EGFR -0.41 0.00014 0.42 0.07321 miRanda -0.4 3.0E-5 NA
75 hsa-miR-140-5p EGLN3 -0.41 0.00014 0.8 0.00273 miRanda -0.32 0.00278 NA
76 hsa-miR-140-5p EIF2S1 -0.41 0.00014 0.28 0.00088 MirTarget; miRanda -0.16 0 NA
77 hsa-miR-140-5p ENTPD5 -0.41 0.00014 -0.56 1.0E-5 MirTarget; miRanda -0.15 0.00448 NA
78 hsa-miR-140-5p EP300 -0.41 0.00014 -0.04 0.77828 miRNAWalker2 validate -0.14 0.00917 NA
79 hsa-miR-140-5p EPB41L4B -0.41 0.00014 0.85 0 miRanda -0.36 0 NA
80 hsa-miR-140-5p EVPL -0.41 0.00014 -1.19 0 miRanda -0.22 0.01894 NA
81 hsa-miR-140-5p FADS1 -0.41 0.00014 1.98 0 MirTarget; PITA; miRanda; miRNATAP -0.19 0.02412 NA
82 hsa-miR-140-5p FAM126A -0.41 0.00014 0.29 0.03416 miRanda -0.13 0.02108 NA
83 hsa-miR-140-5p FAM131A -0.41 0.00014 0.41 0.00406 miRanda -0.13 0.02056 NA
84 hsa-miR-140-5p FAM199X -0.41 0.00014 0.12 0.21175 miRanda -0.11 0.00348 NA
85 hsa-miR-140-5p FAM57A -0.41 0.00014 0.46 0 miRanda -0.22 0 NA
86 hsa-miR-140-5p FAM69A -0.41 0.00014 1.03 0 miRanda -0.21 2.0E-5 NA
87 hsa-miR-140-5p FAM91A1 -0.41 0.00014 0.66 0 miRanda -0.15 2.0E-5 NA
88 hsa-miR-140-5p FAT1 -0.41 0.00014 0.93 4.0E-5 miRanda -0.31 0.00075 NA
89 hsa-miR-140-5p FBN2 -0.41 0.00014 2.91 0 PITA; miRanda; miRNATAP -0.36 0.01971 NA
90 hsa-miR-140-5p FBXO45 -0.41 0.00014 0.88 0 PITA; miRanda -0.27 0 NA
91 hsa-miR-140-5p FGD6 -0.41 0.00014 1.26 0 miRanda -0.13 0.02735 NA
92 hsa-miR-140-5p FOXN2 -0.41 0.00014 0.58 0 PITA; miRanda; miRNATAP -0.11 0.03857 NA
93 hsa-miR-140-5p FRMD6 -0.41 0.00014 0.25 0.05024 miRanda -0.3 0 NA
94 hsa-miR-140-5p FRS2 -0.41 0.00014 0.09 0.42195 PITA; miRanda -0.11 0.01416 NA
95 hsa-miR-140-5p FUT1 -0.41 0.00014 0.41 0.00287 miRanda -0.14 0.01016 NA
96 hsa-miR-140-5p FUT11 -0.41 0.00014 0.15 0.26383 miRanda -0.15 0.00475 NA
97 hsa-miR-140-5p FZD6 -0.41 0.00014 0.96 0 MirTarget; miRanda -0.3 0 NA
98 hsa-miR-140-5p GALK2 -0.41 0.00014 0.22 0.00363 miRanda -0.14 0 NA
99 hsa-miR-140-5p GALNT6 -0.41 0.00014 1.74 0 miRanda -0.57 0 NA
100 hsa-miR-140-5p GFM1 -0.41 0.00014 0.22 0.01084 miRanda -0.12 0.00036 NA
101 hsa-miR-140-5p GJB3 -0.41 0.00014 0.99 0 miRanda -0.3 0.0004 NA
102 hsa-miR-140-5p GM2A -0.41 0.00014 0.36 0.00672 miRanda -0.12 0.02552 NA
103 hsa-miR-140-5p GNG12 -0.41 0.00014 -0.23 0.02505 PITA; miRanda -0.13 0.00109 NA
104 hsa-miR-140-5p GPNMB -0.41 0.00014 1.08 0 miRanda -0.39 3.0E-5 NA
105 hsa-miR-140-5p GPR161 -0.41 0.00014 1.32 0 PITA; miRanda; miRNATAP -0.14 0.024 NA
106 hsa-miR-140-5p GRIA3 -0.41 0.00014 1.64 0 miRanda -0.38 0.00381 NA
107 hsa-miR-140-5p GTF2A1 -0.41 0.00014 -0.27 0.18436 MirTarget -0.24 0.00337 NA
108 hsa-miR-140-5p GTF2H3 -0.41 0.00014 0.26 0.0251 miRanda -0.13 0.00365 NA
109 hsa-miR-140-5p HBEGF -0.41 0.00014 -0.34 0.09465 miRanda -0.17 0.04543 NA
110 hsa-miR-140-5p HPRT1 -0.41 0.00014 0.9 0 miRanda -0.13 0.00154 NA
111 hsa-miR-140-5p HSPA4L -0.41 0.00014 -0.37 0.0498 PITA; miRanda -0.22 0.00459 NA
112 hsa-miR-140-5p IFFO2 -0.41 0.00014 -0.6 0.00426 miRanda; miRNATAP -0.19 0.02402 NA
113 hsa-miR-140-5p IGF1R -0.41 0.00014 0.66 0 PITA; miRNATAP -0.22 2.0E-5 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC
114 hsa-miR-140-5p IGF2BP1 -0.41 0.00014 5.27 0 PITA -0.48 0.03641 27588393 MicroRNA 140 5p targets insulin like growth factor 2 mRNA binding protein 1 IGF2BP1 to suppress cervical cancer growth and metastasis; Furthermore Insulin like growth factor 2 mRNA binding protein 1 IGF2BP1 was identified as a direct target of miR-140-5p and both gain-of-function and loss-of-function assays revealed that IGF2BP1 is also a functional target of miR-140-5p
115 hsa-miR-140-5p IGFBP2 -0.41 0.00014 0.24 0.42806 miRanda -0.41 0.00104 NA
116 hsa-miR-140-5p IGSF3 -0.41 0.00014 0.79 0 MirTarget; PITA; miRanda; miRNATAP -0.32 0 NA
117 hsa-miR-140-5p IL11 -0.41 0.00014 4.18 0 miRanda -0.43 0.00154 NA
118 hsa-miR-140-5p IL1A -0.41 0.00014 2.01 0 miRanda -0.46 0.00165 NA
119 hsa-miR-140-5p IL1RAP -0.41 0.00014 0.49 0.00341 miRanda -0.24 0.00052 NA
120 hsa-miR-140-5p IL6R -0.41 0.00014 -0.05 0.80939 miRanda -0.17 0.03895 NA
121 hsa-miR-140-5p INSIG2 -0.41 0.00014 0.28 0.00027 miRanda -0.12 0.00018 NA
122 hsa-miR-140-5p INTS2 -0.41 0.00014 0.15 0.15719 miRanda -0.12 0.00452 NA
123 hsa-miR-140-5p INTS8 -0.41 0.00014 0.62 0 miRanda -0.11 0.00018 NA
124 hsa-miR-140-5p IPPK -0.41 0.00014 -0.06 0.68489 miRanda -0.11 0.04651 NA
125 hsa-miR-140-5p IQCA1 -0.41 0.00014 0.43 0.22908 miRanda -0.34 0.02131 NA
126 hsa-miR-140-5p IQCH -0.41 0.00014 0.44 0.00367 miRanda -0.19 0.00162 NA
127 hsa-miR-140-5p IRF6 -0.41 0.00014 0.55 0.00031 MirTarget -0.3 0 NA
128 hsa-miR-140-5p IRX2 -0.41 0.00014 0.57 0.06913 miRanda -0.28 0.02778 NA
129 hsa-miR-140-5p ITM2B -0.41 0.00014 -0.29 0.00564 miRanda -0.11 0.00824 NA
130 hsa-miR-140-5p JAG1 -0.41 0.00014 0.99 0 MirTarget; PITA; miRanda; miRNATAP -0.23 0.00021 NA
131 hsa-miR-140-5p JAG2 -0.41 0.00014 0.83 0 miRanda -0.14 0.00949 NA
132 hsa-miR-140-5p JKAMP -0.41 0.00014 0.32 3.0E-5 miRanda -0.15 0 NA
133 hsa-miR-140-5p KCTD11 -0.41 0.00014 -0.04 0.80016 miRanda -0.29 1.0E-5 NA
134 hsa-miR-140-5p KDELR2 -0.41 0.00014 0.42 0 miRanda -0.1 0.00121 NA
135 hsa-miR-140-5p KDM1B -0.41 0.00014 0.3 0.00612 miRanda -0.17 0.00014 NA
136 hsa-miR-140-5p KIF13A -0.41 0.00014 0.1 0.50761 miRanda -0.22 0.00035 NA
137 hsa-miR-140-5p KLC1 -0.41 0.00014 -0.04 0.58887 miRanda -0.11 0.0006 NA
138 hsa-miR-140-5p KLF5 -0.41 0.00014 -0.62 0.00018 miRanda -0.28 3.0E-5 NA
139 hsa-miR-140-5p KLK10 -0.41 0.00014 -0.81 0.0644 MirTarget; miRanda; miRNATAP -0.54 0.0023 NA
140 hsa-miR-140-5p KLK7 -0.41 0.00014 -1.32 0.0122 miRanda -0.56 0.00843 NA
141 hsa-miR-140-5p KLK9 -0.41 0.00014 0.94 0.06338 miRanda -0.71 0.00052 NA
142 hsa-miR-140-5p KRT77 -0.41 0.00014 -0.24 0.59494 miRanda -0.4 0.02848 NA
143 hsa-miR-140-5p KRTAP4-1 -0.41 0.00014 2.73 0 miRanda -0.68 0 NA
144 hsa-miR-140-5p LAD1 -0.41 0.00014 0.34 0.06278 miRanda -0.35 0 NA
145 hsa-miR-140-5p LAMC1 -0.41 0.00014 1.06 0 MirTarget; PITA; miRanda; miRNATAP -0.15 0.00751 NA
146 hsa-miR-140-5p LCLAT1 -0.41 0.00014 0.63 0 miRanda -0.24 0 NA
147 hsa-miR-140-5p LEPROT -0.41 0.00014 -0.31 0.09953 miRanda -0.15 0.04566 NA
148 hsa-miR-140-5p LIMS1 -0.41 0.00014 0.2 0.25634 miRanda -0.2 0.00499 NA
149 hsa-miR-140-5p LMTK2 -0.41 0.00014 -0.53 0.00767 miRanda -0.21 0.00993 NA
150 hsa-miR-140-5p LNX2 -0.41 0.00014 -0.28 0.00852 miRanda -0.2 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 56 1518 1.601e-07 0.000745
2 EPITHELIUM DEVELOPMENT 40 945 3.956e-07 0.0009203
3 REGULATION OF EPITHELIAL CELL PROLIFERATION 19 285 9.82e-07 0.001523
4 POSITIVE REGULATION OF FAT CELL DIFFERENTIATION 8 51 3.107e-06 0.002891
5 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 59 1784 2.639e-06 0.002891
6 RESPONSE TO ENDOGENOUS STIMULUS 50 1450 5.52e-06 0.002926
7 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 60 1848 3.84e-06 0.002926
8 NOTCH SIGNALING PATHWAY 11 114 6.273e-06 0.002926
9 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 25 513 6.288e-06 0.002926
10 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 39 1008 4.928e-06 0.002926
11 CELLULAR RESPONSE TO HORMONE STIMULUS 26 552 7.504e-06 0.003174
12 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 54 1656 1.121e-05 0.004012
13 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 8 60 1.086e-05 0.004012
14 REGULATION OF FAT CELL DIFFERENTIATION 10 106 2.019e-05 0.006264
15 POSITIVE REGULATION OF OSSIFICATION 9 84 1.886e-05 0.006264
16 REGULATION OF CELLULAR LOCALIZATION 44 1277 2.182e-05 0.006346
17 REGULATION OF CELLULAR COMPONENT MOVEMENT 31 771 2.347e-05 0.006424
18 CELL JUNCTION ORGANIZATION 13 185 2.951e-05 0.007228
19 RESPONSE TO HORMONE 34 893 2.862e-05 0.007228
20 REGULATION OF OSTEOBLAST DIFFERENTIATION 10 112 3.265e-05 0.007595
21 CELLULAR RESPONSE TO STRESS 50 1565 4.197e-05 0.009298
22 LOCOMOTION 39 1114 4.701e-05 0.009511
23 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 11 141 4.675e-05 0.009511
24 ORGAN MORPHOGENESIS 32 841 5.018e-05 0.009729
NumGOOverlapSizeP ValueAdj. P Value
1 RIBONUCLEOTIDE BINDING 62 1860 1.074e-06 0.0004991
2 ADENYL NUCLEOTIDE BINDING 54 1514 7.914e-07 0.0004991
3 HYDROLASE ACTIVITY ACTING ON ACID ANHYDRIDES 33 820 1.246e-05 0.002894
4 ENZYME BINDING 56 1737 1.048e-05 0.002894
5 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 15 228 1.598e-05 0.002969
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 52 1151 6.185e-10 3.612e-07
2 GOLGI APPARATUS 52 1445 1.002e-06 0.0002925
3 CELL CELL JUNCTION 22 383 1.686e-06 0.0003282
4 ANCHORING JUNCTION 24 489 8.585e-06 0.001253
5 PLASMA MEMBRANE REGION 35 929 2.701e-05 0.003155
6 CELL SUBSTRATE JUNCTION 20 398 3.489e-05 0.003396
7 CELL LEADING EDGE 18 350 6.371e-05 0.005315
8 APICAL JUNCTION COMPLEX 10 128 0.0001018 0.006603
9 CYTOSKELETON 58 1967 9.211e-05 0.006603

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 HIF_1_signaling_pathway_hsa04066 9 100 7.589e-05 0.003946
2 Adherens_junction_hsa04520 7 72 0.0002963 0.006554
3 Regulation_of_actin_cytoskeleton_hsa04810 12 208 0.0003781 0.006554
4 PI3K_Akt_signaling_pathway_hsa04151 16 352 0.0006329 0.008227
5 ErbB_signaling_pathway_hsa04012 7 85 0.000815 0.008476
6 Notch_signaling_pathway_hsa04330 5 48 0.001607 0.01356
7 Hippo_signaling_pathway_hsa04390 9 154 0.001825 0.01356
8 Focal_adhesion_hsa04510 10 199 0.003156 0.02052
9 Wnt_signaling_pathway_hsa04310 8 146 0.004767 0.02754
10 MAPK_signaling_pathway_hsa04010 12 295 0.007012 0.03646
11 Rap1_signaling_pathway_hsa04015 9 206 0.01197 0.05657
12 AMPK_signaling_pathway_hsa04152 6 121 0.02153 0.09328
13 Jak_STAT_signaling_pathway_hsa04630 7 162 0.02654 0.1061
14 FoxO_signaling_pathway_hsa04068 6 132 0.03125 0.1098
15 Endocytosis_hsa04144 9 244 0.03169 0.1098
16 TNF_signaling_pathway_hsa04668 5 108 0.04435 0.1441
17 TGF_beta_signaling_pathway_hsa04350 4 84 0.06347 0.1941
18 Gap_junction_hsa04540 4 88 0.07268 0.21
19 VEGF_signaling_pathway_hsa04370 3 59 0.0884 0.2419
20 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.09413 0.2447
21 Cytokine_cytokine_receptor_interaction_hsa04060 8 270 0.1119 0.277
22 Ras_signaling_pathway_hsa04014 7 232 0.1228 0.2903
23 mTOR_signaling_pathway_hsa04150 5 151 0.1339 0.3027
24 Cell_cycle_hsa04110 4 124 0.1814 0.3691
25 Oocyte_meiosis_hsa04114 4 124 0.1814 0.3691
26 Tight_junction_hsa04530 5 170 0.1884 0.3691
27 ABC_transporters_hsa02010 2 45 0.1916 0.3691
28 Hedgehog_signaling_pathway_hsa04340 2 47 0.2047 0.3801
29 Cell_adhesion_molecules_.CAMs._hsa04514 4 145 0.2603 0.4667
30 cAMP_signaling_pathway_hsa04024 5 198 0.2798 0.485
31 Cellular_senescence_hsa04218 4 160 0.3201 0.5369
32 Sphingolipid_signaling_pathway_hsa04071 3 118 0.3524 0.5726
33 Autophagy_animal_hsa04140 3 128 0.4008 0.6316
34 ECM_receptor_interaction_hsa04512 2 82 0.4317 0.6542
35 Apelin_signaling_pathway_hsa04371 3 137 0.4435 0.6542
36 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 3 139 0.4529 0.6542
37 Phospholipase_D_signaling_pathway_hsa04072 3 146 0.485 0.6816
38 Phagosome_hsa04145 3 152 0.5118 0.6851
39 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.53 0.689
40 cGMP_PKG_signaling_pathway_hsa04022 3 163 0.559 0.709
41 Apoptosis_hsa04210 2 138 0.7089 0.8573
42 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.9604 1

Quest ID: 2c1012f351ac453660a7e8b3ef6942e8