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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-200c-3p ABAT 6.44 0.04826 0.12 0.90428 MirTarget -0.18 0.00957 NA
2 hsa-miR-200c-3p ACTC1 6.44 0.04826 -6.29 2.0E-5 MirTarget -0.55 0 NA
3 hsa-miR-200c-3p ADAMTS3 6.44 0.04826 -3.41 0.00362 miRNATAP -0.38 6.0E-5 NA
4 hsa-miR-200c-3p ADCY2 6.44 0.04826 -6.09 4.0E-5 MirTarget; miRNATAP -0.37 0.00506 NA
5 hsa-miR-200c-3p AFF3 6.44 0.04826 -4.85 0 MirTarget; miRNATAP -0.55 0 NA
6 hsa-miR-200c-3p AMOTL2 6.44 0.04826 -0.85 0.57408 MirTarget; miRNATAP -0.13 0.00723 NA
7 hsa-miR-200c-3p AP1S2 6.44 0.04826 -2.94 0.00156 MirTarget; miRNATAP -0.33 0 NA
8 hsa-miR-200c-3p ARHGAP20 6.44 0.04826 -3.46 0.00119 MirTarget; miRNATAP -0.52 0 NA
9 hsa-miR-200c-3p ARHGAP28 6.44 0.04826 -2.42 0.05137 MirTarget -0.36 0.0008 NA
10 hsa-miR-200c-3p ARHGAP6 6.44 0.04826 -5.57 0 MirTarget -0.51 0 NA
11 hsa-miR-200c-3p ARHGEF17 6.44 0.04826 -2.26 0.08671 miRNATAP -0.18 2.0E-5 NA
12 hsa-miR-200c-3p ARL15 6.44 0.04826 -0.83 0.3694 MirTarget -0.15 0.00286 NA
13 hsa-miR-200c-3p ARL2BP 6.44 0.04826 -0.87 0.50235 miRNATAP -0.12 0 NA
14 hsa-miR-200c-3p ASAP1 6.44 0.04826 -0.06 0.96156 MirTarget; miRNATAP -0.11 0.00254 NA
15 hsa-miR-200c-3p ATP11C 6.44 0.04826 -0.88 0.45046 MirTarget -0.11 0.01482 NA
16 hsa-miR-200c-3p ATXN1 6.44 0.04826 -1.44 0.25265 MirTarget; miRNATAP -0.18 2.0E-5 NA
17 hsa-miR-200c-3p BASP1 6.44 0.04826 -0.81 0.54727 miRNATAP -0.29 0.00304 NA
18 hsa-miR-200c-3p BCL2 6.44 0.04826 -3 0.00289 miRNAWalker2 validate; miRTarBase -0.2 0.00073 NA
19 hsa-miR-200c-3p BNC2 6.44 0.04826 -6.05 0 MirTarget -0.65 0 NA
20 hsa-miR-200c-3p C11orf87 6.44 0.04826 -4.01 0.01618 miRNATAP -0.41 0.00012 NA
21 hsa-miR-200c-3p CACNA1C 6.44 0.04826 -5.6 0 MirTarget -0.48 0 NA
22 hsa-miR-200c-3p CALU 6.44 0.04826 -0.87 0.62368 MirTarget -0.11 0.00144 NA
23 hsa-miR-200c-3p CBL 6.44 0.04826 -0.2 0.86836 MirTarget -0.1 0.00481 NA
24 hsa-miR-200c-3p CDK17 6.44 0.04826 -1.04 0.33689 MirTarget; miRNATAP -0.11 0.00023 NA
25 hsa-miR-200c-3p CELF2 6.44 0.04826 -2.38 0.01903 miRNATAP -0.27 4.0E-5 NA
26 hsa-miR-200c-3p CEP68 6.44 0.04826 -1.72 0.10628 MirTarget -0.13 0.00021 NA
27 hsa-miR-200c-3p CFL2 6.44 0.04826 -3.42 0.0048 MirTarget; miRNATAP -0.21 0 23497265 We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c
28 hsa-miR-200c-3p CHD9 6.44 0.04826 -0.24 0.84856 miRNATAP -0.11 0.00301 NA
29 hsa-miR-200c-3p CHN2 6.44 0.04826 -2.74 0.00636 MirTarget -0.18 0.01746 NA
30 hsa-miR-200c-3p CHRDL1 6.44 0.04826 -10.04 0 MirTarget -0.93 0 NA
31 hsa-miR-200c-3p CHST2 6.44 0.04826 -0.31 0.78268 miRNATAP -0.2 0.02082 NA
32 hsa-miR-200c-3p CITED2 6.44 0.04826 -2.88 0.03163 miRNATAP -0.15 0.00238 NA
33 hsa-miR-200c-3p CLIC4 6.44 0.04826 -1.99 0.24387 MirTarget; miRNATAP -0.2 0 NA
34 hsa-miR-200c-3p CLIP2 6.44 0.04826 -1.96 0.13839 MirTarget; miRNATAP -0.18 0.00063 NA
35 hsa-miR-200c-3p CNN3 6.44 0.04826 -1.91 0.26317 MirTarget; miRNATAP -0.16 6.0E-5 NA
36 hsa-miR-200c-3p CNTFR 6.44 0.04826 -3.84 0.04568 miRNATAP -0.62 9.0E-5 NA
37 hsa-miR-200c-3p CNTN1 6.44 0.04826 -2.59 0.16326 MirTarget; miRNATAP -0.32 0.04972 NA
38 hsa-miR-200c-3p CNTN4 6.44 0.04826 -4.67 6.0E-5 miRNATAP -0.47 0 NA
39 hsa-miR-200c-3p CREB5 6.44 0.04826 -1.85 0.14608 miRNATAP -0.23 0.01024 NA
40 hsa-miR-200c-3p CTNND2 6.44 0.04826 -1.51 0.32136 MirTarget; miRNATAP -0.25 0.02473 NA
41 hsa-miR-200c-3p CYP1B1 6.44 0.04826 -3.76 0.00499 miRNATAP -0.5 0 25860934 Loss of miR 200c up regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma; Additionally miR-200c which is significantly down-regulated in RCC regulates CYP1B1 expression and activity; An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues; Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c; These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel; Therefore expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response
42 hsa-miR-200c-3p CYTH3 6.44 0.04826 -1.46 0.22002 MirTarget -0.14 0.00023 NA
43 hsa-miR-200c-3p DACT1 6.44 0.04826 -3.43 0.0018 miRNATAP -0.47 0 NA
44 hsa-miR-200c-3p DDIT4L 6.44 0.04826 -4.72 0.00087 MirTarget -0.29 0.02198 NA
45 hsa-miR-200c-3p DIXDC1 6.44 0.04826 -4.41 1.0E-5 MirTarget -0.35 0 NA
46 hsa-miR-200c-3p DLC1 6.44 0.04826 -3.78 0.00054 miRNATAP -0.39 0 NA
47 hsa-miR-200c-3p DMD 6.44 0.04826 -4.19 0.00094 miRNATAP -0.28 0.0054 NA
48 hsa-miR-200c-3p DNAJB5 6.44 0.04826 -2.26 0.01674 miRNATAP -0.26 0 NA
49 hsa-miR-200c-3p DOCK4 6.44 0.04826 -2.04 0.01065 MirTarget -0.33 0 NA
50 hsa-miR-200c-3p DTNA 6.44 0.04826 -4.61 2.0E-5 MirTarget -0.38 5.0E-5 NA
51 hsa-miR-200c-3p DUSP1 6.44 0.04826 -2.25 0.23358 MirTarget; miRNATAP -0.19 0.0147 NA
52 hsa-miR-200c-3p DZIP1 6.44 0.04826 -2.66 0.01873 MirTarget -0.31 9.0E-5 NA
53 hsa-miR-200c-3p EDNRA 6.44 0.04826 -3.9 0.00075 miRNAWalker2 validate; miRNATAP -0.48 0 NA
54 hsa-miR-200c-3p ENTPD1 6.44 0.04826 -1.63 0.20648 MirTarget -0.17 0 NA
55 hsa-miR-200c-3p ETS1 6.44 0.04826 -1.33 0.37178 MirTarget; miRNATAP -0.21 4.0E-5 NA
56 hsa-miR-200c-3p ETV5 6.44 0.04826 -1.26 0.34376 MirTarget; miRNATAP -0.15 0.03993 27276064 Another study suggested that ERM expression was regulated directly by miR-200c and had a critical role in miR-200c suppressing cell migration
57 hsa-miR-200c-3p F2RL2 6.44 0.04826 -2.16 0.03263 MirTarget -0.34 6.0E-5 NA
58 hsa-miR-200c-3p FAM19A2 6.44 0.04826 -2.13 0.01478 MirTarget -0.19 0.01302 NA
59 hsa-miR-200c-3p FAT3 6.44 0.04826 -3.42 0.02832 MirTarget; miRNATAP -0.49 6.0E-5 NA
60 hsa-miR-200c-3p FBLN5 6.44 0.04826 -4.98 0.00016 miRNAWalker2 validate; miRTarBase -0.42 0 NA
61 hsa-miR-200c-3p FGF18 6.44 0.04826 -3.51 0.00274 miRNATAP -0.26 0.02167 NA
62 hsa-miR-200c-3p FHL1 6.44 0.04826 -6.42 0 MirTarget -0.7 0 NA
63 hsa-miR-200c-3p FLI1 6.44 0.04826 -2.35 0.00534 MirTarget; miRNATAP -0.29 0 NA
64 hsa-miR-200c-3p FLNA 6.44 0.04826 -2.56 0.24492 miRNAWalker2 validate -0.29 0 NA
65 hsa-miR-200c-3p FLT1 6.44 0.04826 -2.51 0.03608 miRNAWalker2 validate; miRTarBase; MirTarget -0.22 1.0E-5 NA
66 hsa-miR-200c-3p FN1 6.44 0.04826 -1.24 0.56309 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.53 0 NA
67 hsa-miR-200c-3p FOXF1 6.44 0.04826 -3.18 0.00025 MirTarget -0.21 0.00153 NA
68 hsa-miR-200c-3p FOXK1 6.44 0.04826 -0.36 0.79228 miRNATAP -0.11 0.00931 NA
69 hsa-miR-200c-3p FRMD6 6.44 0.04826 -1.1 0.30983 miRNATAP -0.32 5.0E-5 NA
70 hsa-miR-200c-3p FSTL1 6.44 0.04826 -2.24 0.24051 MirTarget -0.24 0.00032 NA
71 hsa-miR-200c-3p FYN 6.44 0.04826 -2.6 0.01592 miRNATAP -0.26 0 NA
72 hsa-miR-200c-3p GEM 6.44 0.04826 -3.79 0.00119 MirTarget; miRNATAP -0.33 0 NA
73 hsa-miR-200c-3p GJC1 6.44 0.04826 -2.93 0.01171 MirTarget; miRNATAP -0.17 0.01977 NA
74 hsa-miR-200c-3p GLI3 6.44 0.04826 -1.48 0.13004 miRNATAP -0.44 0 NA
75 hsa-miR-200c-3p GLIS2 6.44 0.04826 -1.54 0.27105 miRNATAP -0.16 0.01016 NA
76 hsa-miR-200c-3p GPM6A 6.44 0.04826 -8.9 0 miRNATAP -0.68 0 NA
77 hsa-miR-200c-3p GPR146 6.44 0.04826 -3.28 0 miRNATAP -0.11 0.01728 NA
78 hsa-miR-200c-3p GPRASP2 6.44 0.04826 -3.01 0.00026 MirTarget -0.21 2.0E-5 NA
79 hsa-miR-200c-3p GREM1 6.44 0.04826 -1.78 0.17022 MirTarget -0.41 2.0E-5 NA
80 hsa-miR-200c-3p HCFC2 6.44 0.04826 -0.9 0.29391 miRNATAP -0.12 2.0E-5 NA
81 hsa-miR-200c-3p HIVEP3 6.44 0.04826 1.38 0.10596 miRNATAP -0.24 0.00047 NA
82 hsa-miR-200c-3p HLF 6.44 0.04826 -4 0.00073 MirTarget; miRNATAP -0.34 0.00085 NA
83 hsa-miR-200c-3p IRS1 6.44 0.04826 -2.43 0.06487 miRNATAP -0.33 0 NA
84 hsa-miR-200c-3p ITGA1 6.44 0.04826 -1.34 0.27217 MirTarget -0.2 0.00124 NA
85 hsa-miR-200c-3p ITPR1 6.44 0.04826 -3.65 0.00026 miRNATAP -0.36 0 NA
86 hsa-miR-200c-3p ITPR2 6.44 0.04826 -0.25 0.81786 MirTarget -0.13 0.00652 NA
87 hsa-miR-200c-3p JAG1 6.44 0.04826 0.58 0.70806 miRNAWalker2 validate -0.23 0.00015 NA
88 hsa-miR-200c-3p JAZF1 6.44 0.04826 -3.33 0.00103 MirTarget; miRNATAP -0.29 0 NA
89 hsa-miR-200c-3p JUN 6.44 0.04826 -1.34 0.49429 MirTarget -0.12 0.02177 NA
90 hsa-miR-200c-3p KANK1 6.44 0.04826 -1.79 0.16305 MirTarget -0.21 6.0E-5 NA
91 hsa-miR-200c-3p KCND2 6.44 0.04826 -2.71 0.01055 MirTarget; miRNATAP -0.37 1.0E-5 NA
92 hsa-miR-200c-3p KCTD15 6.44 0.04826 0.08 0.94645 MirTarget; miRNATAP -0.17 0.00988 NA
93 hsa-miR-200c-3p KDR 6.44 0.04826 -3.82 0.00021 miRNATAP -0.38 0 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c
94 hsa-miR-200c-3p KIAA0040 6.44 0.04826 -0.72 0.59304 MirTarget -0.11 0.01255 NA
95 hsa-miR-200c-3p KIAA1462 6.44 0.04826 -4.26 3.0E-5 MirTarget -0.36 0 NA
96 hsa-miR-200c-3p KIF13A 6.44 0.04826 -0.67 0.57645 miRNATAP -0.1 0.04987 NA
97 hsa-miR-200c-3p KLF9 6.44 0.04826 -3.74 0.00312 miRNAWalker2 validate; miRTarBase; miRNATAP -0.24 2.0E-5 NA
98 hsa-miR-200c-3p KLHDC1 6.44 0.04826 -2.44 0.00032 MirTarget -0.18 0.00125 NA
99 hsa-miR-200c-3p KLHL3 6.44 0.04826 -2 0.01046 miRNATAP -0.18 0.00349 NA
100 hsa-miR-200c-3p LAMC1 6.44 0.04826 -1.19 0.52385 MirTarget; miRNATAP -0.11 0.03256 NA
101 hsa-miR-200c-3p LATS2 6.44 0.04826 -1.66 0.13092 miRNATAP -0.14 0.00059 NA
102 hsa-miR-200c-3p LCA5 6.44 0.04826 -1.91 0.02782 MirTarget -0.12 0.03516 NA
103 hsa-miR-200c-3p LHFP 6.44 0.04826 -3.69 0.0004 MirTarget; miRNATAP -0.36 0 NA
104 hsa-miR-200c-3p LIX1L 6.44 0.04826 -2.88 0.00683 MirTarget -0.25 0 NA
105 hsa-miR-200c-3p MAF 6.44 0.04826 -1.29 0.26207 miRNATAP -0.28 0.00032 NA
106 hsa-miR-200c-3p MARCH1 6.44 0.04826 1.44 0.02712 MirTarget -0.15 0.0083 NA
107 hsa-miR-200c-3p MARCH8 6.44 0.04826 -0.91 0.29784 MirTarget -0.16 0.00606 NA
108 hsa-miR-200c-3p MBNL2 6.44 0.04826 -1.06 0.43367 miRNATAP -0.12 0.01377 NA
109 hsa-miR-200c-3p MEGF10 6.44 0.04826 -3.7 0.0023 MirTarget -0.37 4.0E-5 NA
110 hsa-miR-200c-3p MEX3B 6.44 0.04826 -1.95 0.03893 miRNATAP -0.23 0.00103 NA
111 hsa-miR-200c-3p MFAP5 6.44 0.04826 -5.84 0.00045 miRNATAP -0.54 0.00015 NA
112 hsa-miR-200c-3p MITF 6.44 0.04826 -4.68 5.0E-5 miRNATAP -0.3 0 NA
113 hsa-miR-200c-3p MPDZ 6.44 0.04826 -3.5 0.00292 MirTarget -0.23 0.00827 NA
114 hsa-miR-200c-3p MPRIP 6.44 0.04826 -1.59 0.32311 MirTarget; miRNATAP -0.11 0.00143 NA
115 hsa-miR-200c-3p MRVI1 6.44 0.04826 -4.9 0 MirTarget -0.52 0 NA
116 hsa-miR-200c-3p MSN 6.44 0.04826 -0.31 0.86168 miRNAWalker2 validate; miRTarBase; MirTarget -0.32 0 NA
117 hsa-miR-200c-3p MTSS1L 6.44 0.04826 -0.79 0.58974 miRNATAP -0.1 0.03058 NA
118 hsa-miR-200c-3p NALCN 6.44 0.04826 -3.05 0.04617 MirTarget -0.4 0.00038 NA
119 hsa-miR-200c-3p NAP1L5 6.44 0.04826 -2.46 0.00581 MirTarget; miRNATAP -0.14 0.02804 NA
120 hsa-miR-200c-3p NCAM1 6.44 0.04826 -7.29 0 miRTarBase -0.54 0 NA
121 hsa-miR-200c-3p NCS1 6.44 0.04826 -1.24 0.3129 miRNATAP -0.25 0 NA
122 hsa-miR-200c-3p NDN 6.44 0.04826 -5.09 0 MirTarget; miRNATAP -0.46 0 NA
123 hsa-miR-200c-3p NDST1 6.44 0.04826 -0.02 0.98742 miRNATAP -0.13 0.00125 NA
124 hsa-miR-200c-3p NEGR1 6.44 0.04826 -5.37 0 miRNATAP -0.51 0 NA
125 hsa-miR-200c-3p NEK9 6.44 0.04826 -0.99 0.49389 MirTarget -0.11 1.0E-5 NA
126 hsa-miR-200c-3p NFASC 6.44 0.04826 -2.05 0.04128 miRNATAP -0.46 0 23185507 miR 200c targets a NF κB up regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer
127 hsa-miR-200c-3p NFIA 6.44 0.04826 -0.84 0.57833 MirTarget; miRNATAP -0.12 0.01827 NA
128 hsa-miR-200c-3p NLGN4X 6.44 0.04826 -3.24 0.04534 miRNATAP -0.48 0.00053 NA
129 hsa-miR-200c-3p NOVA1 6.44 0.04826 -6.4 0 MirTarget; miRNATAP -0.69 0 NA
130 hsa-miR-200c-3p NR2F2 6.44 0.04826 -3.51 0.03086 miRNATAP -0.18 0.00551 NA
131 hsa-miR-200c-3p NR5A2 6.44 0.04826 -3.71 1.0E-5 miRNATAP -0.29 1.0E-5 NA
132 hsa-miR-200c-3p NRIP1 6.44 0.04826 0.25 0.86048 MirTarget; miRNATAP -0.11 0.01997 NA
133 hsa-miR-200c-3p NTF3 6.44 0.04826 -3.57 0.00707 miRNAWalker2 validate; miRNATAP -0.27 0.01286 NA
134 hsa-miR-200c-3p NTRK2 6.44 0.04826 -1.16 0.51501 miRNAWalker2 validate; miRTarBase -0.45 0.00376 23209748; 23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis
135 hsa-miR-200c-3p OSR1 6.44 0.04826 -3.87 0.00122 miRNATAP -0.22 0.0278 NA
136 hsa-miR-200c-3p OSTM1 6.44 0.04826 -0.98 0.39153 MirTarget -0.14 0 NA
137 hsa-miR-200c-3p PALM2-AKAP2 6.44 0.04826 -3.09 0.01102 miRNATAP -0.31 0 NA
138 hsa-miR-200c-3p PAM 6.44 0.04826 -2.22 0.22435 miRNATAP -0.14 0.00214 NA
139 hsa-miR-200c-3p PCDH10 6.44 0.04826 -4 0.0105 MirTarget -0.41 0.00024 NA
140 hsa-miR-200c-3p PCDH8 6.44 0.04826 -1.8 0.38138 miRNATAP -0.48 0.00088 NA
141 hsa-miR-200c-3p PCSK2 6.44 0.04826 -5.08 0.00497 miRNATAP -0.37 0.00171 NA
142 hsa-miR-200c-3p PDE5A 6.44 0.04826 -2.55 0.02803 miRNATAP -0.13 0.03654 NA
143 hsa-miR-200c-3p PDE7B 6.44 0.04826 -4.37 0 miRNATAP -0.4 0 NA
144 hsa-miR-200c-3p PHACTR2 6.44 0.04826 -1.27 0.30374 MirTarget; miRNATAP -0.12 0.00245 NA
145 hsa-miR-200c-3p PHEX 6.44 0.04826 -0.69 0.58229 MirTarget -0.26 0.00879 NA
146 hsa-miR-200c-3p PHF21B 6.44 0.04826 -5.18 0.00015 MirTarget -0.43 0.00011 NA
147 hsa-miR-200c-3p PHLDB1 6.44 0.04826 -2.34 0.12016 MirTarget; miRNATAP -0.18 0.00045 NA
148 hsa-miR-200c-3p PLCL1 6.44 0.04826 -4.16 0 MirTarget -0.5 0 NA
149 hsa-miR-200c-3p PLK2 6.44 0.04826 -0.17 0.90795 miRNATAP -0.18 0.01117 NA
150 hsa-miR-200c-3p PLXNA4 6.44 0.04826 -4.16 0.00041 miRNATAP -0.41 5.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 60 1672 2.246e-15 1.045e-11
2 CELL DEVELOPMENT 50 1426 1.988e-12 4.625e-09
3 REGULATION OF CELLULAR COMPONENT MOVEMENT 35 771 6.664e-12 1.034e-08
4 REGULATION OF NEURON DIFFERENTIATION 29 554 1.746e-11 2.031e-08
5 REGULATION OF CELL DIFFERENTIATION 49 1492 3.599e-11 2.85e-08
6 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 42 1142 3.675e-11 2.85e-08
7 CARDIOVASCULAR SYSTEM DEVELOPMENT 34 788 5.432e-11 3.16e-08
8 CIRCULATORY SYSTEM DEVELOPMENT 34 788 5.432e-11 3.16e-08
9 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 39 1021 6.776e-11 3.503e-08
10 TISSUE DEVELOPMENT 48 1518 2.174e-10 1.012e-07
11 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 32 750 2.818e-10 1.092e-07
12 REGULATION OF CELL DEVELOPMENT 34 836 2.601e-10 1.092e-07
13 VASCULATURE DEVELOPMENT 25 469 3.28e-10 1.174e-07
14 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 44 1395 1.549e-09 5.147e-07
15 NEUROGENESIS 44 1402 1.806e-09 5.603e-07
16 BLOOD VESSEL MORPHOGENESIS 21 364 2.278e-09 6.626e-07
17 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 41 1275 3.555e-09 9.73e-07
18 CELLULAR COMPONENT MORPHOGENESIS 33 900 6.51e-09 1.683e-06
19 BIOLOGICAL ADHESION 35 1032 1.566e-08 3.836e-06
20 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 33 957 2.861e-08 6.657e-06
21 HEART DEVELOPMENT 22 466 3.569e-08 7.907e-06
22 POSITIVE REGULATION OF CELL DIFFERENTIATION 30 823 3.878e-08 8.202e-06
23 CELL JUNCTION ORGANIZATION 14 185 4.186e-08 8.468e-06
24 MESENCHYME DEVELOPMENT 14 190 5.852e-08 1.135e-05
25 INTRACELLULAR SIGNAL TRANSDUCTION 43 1572 1.515e-07 2.82e-05
26 POSITIVE REGULATION OF CELL COMMUNICATION 42 1532 2.046e-07 3.661e-05
27 EPITHELIUM DEVELOPMENT 31 945 2.369e-07 3.971e-05
28 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 44 1656 2.39e-07 3.971e-05
29 CELL JUNCTION ASSEMBLY 11 129 3.674e-07 5.895e-05
30 REGULATION OF NEURON PROJECTION DEVELOPMENT 19 408 3.912e-07 6.068e-05
31 REGULATION OF CELL PROJECTION ORGANIZATION 22 558 7.875e-07 0.0001122
32 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 21 513 7.783e-07 0.0001122
33 REGULATION OF CELL PROLIFERATION 40 1496 7.956e-07 0.0001122
34 POSITIVE REGULATION OF CELL DEVELOPMENT 20 472 8.465e-07 0.0001158
35 RESPONSE TO WOUNDING 22 563 9.133e-07 0.0001174
36 LOCOMOTION 33 1114 9.332e-07 0.0001174
37 CELL PROJECTION ORGANIZATION 29 902 9.05e-07 0.0001174
38 NEURON PROJECTION DEVELOPMENT 21 545 2.039e-06 0.0002372
39 CELL MOTILITY 27 835 1.994e-06 0.0002372
40 LOCALIZATION OF CELL 27 835 1.994e-06 0.0002372
41 EMBRYO DEVELOPMENT 28 894 2.353e-06 0.000267
42 POSITIVE REGULATION OF RESPONSE TO STIMULUS 46 1929 2.519e-06 0.0002726
43 REGULATION OF CELL MORPHOGENESIS 21 552 2.492e-06 0.0002726
44 POSITIVE REGULATION OF NEURON DIFFERENTIATION 15 306 3.643e-06 0.0003852
45 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 18 437 4.518e-06 0.000457
46 CENTRAL NERVOUS SYSTEM DEVELOPMENT 27 872 4.465e-06 0.000457
47 POSITIVE REGULATION OF MOLECULAR FUNCTION 43 1791 4.832e-06 0.0004783
48 REGULATION OF CELL ADHESION 22 629 5.513e-06 0.0005344
49 CELL PART MORPHOGENESIS 22 633 6.094e-06 0.0005787
50 NEURON DEVELOPMENT 23 687 6.847e-06 0.0006127
51 ACTIN FILAMENT BASED PROCESS 18 450 6.76e-06 0.0006127
52 EPITHELIAL CELL DIFFERENTIATION 19 495 6.727e-06 0.0006127
53 POSITIVE REGULATION OF CATALYTIC ACTIVITY 38 1518 7.368e-06 0.0006468
54 REGULATION OF EPITHELIAL CELL PROLIFERATION 14 285 7.543e-06 0.0006499
55 CELL SUBSTRATE JUNCTION ASSEMBLY 6 41 7.869e-06 0.0006658
56 REGULATION OF BODY FLUID LEVELS 19 506 9.18e-06 0.0007628
57 ANGIOGENESIS 14 293 1.032e-05 0.0008427
58 POSITIVE REGULATION OF LOCOMOTION 17 420 1.051e-05 0.0008434
59 NEURON DIFFERENTIATION 26 874 1.37e-05 0.00108
60 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 26 876 1.425e-05 0.001105
61 NEGATIVE REGULATION OF LOCOMOTION 13 263 1.5e-05 0.001144
62 RESPONSE TO ENDOGENOUS STIMULUS 36 1450 1.585e-05 0.001171
63 REGULATION OF GTPASE ACTIVITY 22 673 1.583e-05 0.001171
64 TISSUE MORPHOGENESIS 19 533 1.895e-05 0.001378
65 HEMOSTASIS 14 311 2.011e-05 0.00144
66 ORGAN MORPHOGENESIS 25 841 2.051e-05 0.001446
67 MORPHOGENESIS OF AN EPITHELIUM 16 400 2.219e-05 0.001518
68 EMBRYONIC MORPHOGENESIS 19 539 2.21e-05 0.001518
69 NEURON PROJECTION MORPHOGENESIS 16 402 2.358e-05 0.00159
70 RENAL SYSTEM PROCESS 8 102 2.737e-05 0.001819
71 TUBE DEVELOPMENT 19 552 3.06e-05 0.001978
72 TUBE MORPHOGENESIS 14 323 3.052e-05 0.001978
73 RESPONSE TO ORGANIC CYCLIC COMPOUND 26 917 3.111e-05 0.001983
74 SINGLE ORGANISM CELL ADHESION 17 459 3.264e-05 0.002052
75 HEAD DEVELOPMENT 22 709 3.489e-05 0.002164
76 REGULATION OF HYDROLASE ACTIVITY 33 1327 3.619e-05 0.002216
77 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 9 138 3.773e-05 0.00228
78 REGULATION OF CELL SUBSTRATE ADHESION 10 173 3.958e-05 0.002361
79 WOUND HEALING 17 470 4.386e-05 0.002583
80 SYNAPSE ORGANIZATION 9 145 5.56e-05 0.003194
81 REGULATION OF CHEMOTAXIS 10 180 5.537e-05 0.003194
82 REGULATION OF MEMBRANE POTENTIAL 14 343 5.854e-05 0.003322
83 POSITIVE REGULATION OF GENE EXPRESSION 39 1733 6.082e-05 0.003409
84 NEPHRON DEVELOPMENT 8 115 6.478e-05 0.003564
85 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 13 303 6.511e-05 0.003564
86 POSITIVE REGULATION OF HYDROLASE ACTIVITY 25 905 6.773e-05 0.003565
87 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 21 689 6.818e-05 0.003565
88 VASCULOGENESIS 6 59 6.612e-05 0.003565
89 EXTRACELLULAR STRUCTURE ORGANIZATION 13 304 6.732e-05 0.003565
90 REGULATION OF PHOSPHORUS METABOLIC PROCESS 37 1618 6.94e-05 0.003588
91 NEGATIVE REGULATION OF CELL PROLIFERATION 20 643 7.745e-05 0.00396
92 RESPONSE TO OXYGEN LEVELS 13 311 8.47e-05 0.004284
93 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 11 229 8.825e-05 0.004368
94 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 6 62 8.76e-05 0.004368
95 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 27 1036 9.126e-05 0.004423
96 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 27 1036 9.126e-05 0.004423
97 REGULATION OF VASCULATURE DEVELOPMENT 11 233 0.0001029 0.004937
98 REGULATION OF MAPK CASCADE 20 660 0.0001102 0.005152
99 CELL CELL ADHESION 19 608 0.0001104 0.005152
100 REGULATION OF SYSTEM PROCESS 17 507 0.0001107 0.005152
101 ACTIN FILAMENT BASED MOVEMENT 7 93 0.0001136 0.005184
102 NEPHRON EPITHELIUM DEVELOPMENT 7 93 0.0001136 0.005184
103 CIRCULATORY SYSTEM PROCESS 14 366 0.0001165 0.005251
104 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 12 278 0.0001174 0.005251
105 ACTION POTENTIAL 7 94 0.0001216 0.005387
106 MUSCLE SYSTEM PROCESS 12 282 0.0001342 0.005883
107 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 32 1360 0.0001353 0.005883
108 REGULATION OF CELL JUNCTION ASSEMBLY 6 68 0.0001471 0.006337
109 REGULATION OF EPITHELIAL CELL MIGRATION 9 166 0.0001569 0.00668
110 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 7 98 0.0001579 0.00668
111 LEARNING 8 131 0.0001614 0.006764
112 NEGATIVE REGULATION OF CELL COMMUNICATION 29 1192 0.0001632 0.00678
113 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 8 133 0.0001791 0.007376
114 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 21 740 0.0001836 0.007495
115 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 13 337 0.0001877 0.007595
116 MUSCLE STRUCTURE DEVELOPMENT 15 432 0.0001931 0.007747
117 REGULATION OF CHONDROCYTE DIFFERENTIATION 5 46 0.0001987 0.0079
118 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 34 1517 0.0002067 0.008151
119 REGULATION OF PROTEIN MODIFICATION PROCESS 37 1710 0.0002126 0.008312
120 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 28 1152 0.0002165 0.008325
121 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 7 103 0.0002152 0.008325
122 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 39 1848 0.0002342 0.008883
123 ACTIN MEDIATED CELL CONTRACTION 6 74 0.0002348 0.008883
124 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 38 1784 0.0002368 0.008885
125 SYSTEM PROCESS 38 1785 0.0002395 0.008913
126 REGULATION OF CELL SHAPE 8 139 0.0002424 0.008951
127 LATERAL MESODERM DEVELOPMENT 3 11 0.0002465 0.00896
128 MODULATION OF SYNAPTIC TRANSMISSION 12 301 0.0002451 0.00896
129 POSITIVE REGULATION OF CELL PROLIFERATION 22 814 0.0002551 0.009201
130 GLOMERULUS DEVELOPMENT 5 49 0.0002686 0.009612
131 PLATELET ACTIVATION 8 142 0.0002803 0.009954
NumGOOverlapSizeP ValueAdj. P Value
1 MOLECULAR FUNCTION REGULATOR 35 1353 8.836e-06 0.008208
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 40 1151 6.173e-10 3.605e-07
2 CELL PROJECTION 51 1786 1.854e-09 5.413e-07
3 MEMBRANE REGION 38 1134 4.803e-09 9.35e-07
4 NEURON PROJECTION 31 942 2.21e-07 3.226e-05
5 MEMBRANE MICRODOMAIN 16 288 3.28e-07 3.832e-05
6 NEURON PART 34 1265 5.367e-06 0.0005224
7 SOMATODENDRITIC COMPARTMENT 22 650 9.24e-06 0.0007709
8 POSTSYNAPSE 16 378 1.108e-05 0.0008086
9 PLASMA MEMBRANE REGION 27 929 1.402e-05 0.0009099
10 EXCITATORY SYNAPSE 11 197 2.246e-05 0.001312
11 DENDRITE 17 451 2.616e-05 0.001389
12 SYNAPSE 23 754 3.002e-05 0.001461

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 15 199 1.435e-08 7.462e-07
2 cGMP_PKG_signaling_pathway_hsa04022 10 163 2.377e-05 0.0006179
3 MAPK_signaling_pathway_hsa04010 13 295 4.957e-05 0.0008322
4 PI3K_Akt_signaling_pathway_hsa04151 14 352 7.72e-05 0.0008322
5 Gap_junction_hsa04540 7 88 8.002e-05 0.0008322
6 Ras_signaling_pathway_hsa04014 11 232 9.907e-05 0.0008586
7 Hippo_signaling_pathway_multiple_species_hsa04392 4 29 0.0003503 0.002602
8 Rap1_signaling_pathway_hsa04015 9 206 0.0007639 0.004965
9 Tight_junction_hsa04530 8 170 0.0009245 0.005342
10 Calcium_signaling_pathway_hsa04020 8 182 0.001432 0.007444
11 Sphingolipid_signaling_pathway_hsa04071 6 118 0.002725 0.01288
12 ErbB_signaling_pathway_hsa04012 5 85 0.003284 0.01423
13 Cell_adhesion_molecules_.CAMs._hsa04514 6 145 0.007413 0.02965
14 cAMP_signaling_pathway_hsa04024 7 198 0.009083 0.03374
15 Oocyte_meiosis_hsa04114 5 124 0.01564 0.05174
16 ECM_receptor_interaction_hsa04512 4 82 0.01592 0.05174
17 Hedgehog_signaling_pathway_hsa04340 3 47 0.01776 0.05434
18 Apelin_signaling_pathway_hsa04371 5 137 0.02299 0.06467
19 Apoptosis_hsa04210 5 138 0.02363 0.06467
20 Phospholipase_D_signaling_pathway_hsa04072 5 146 0.0292 0.07177
21 Phosphatidylinositol_signaling_system_hsa04070 4 99 0.02941 0.07177
22 HIF_1_signaling_pathway_hsa04066 4 100 0.03037 0.07177
23 VEGF_signaling_pathway_hsa04370 3 59 0.03217 0.07272
24 Hippo_signaling_pathway_hsa04390 5 154 0.03554 0.07701
25 Mitophagy_animal_hsa04137 3 65 0.04109 0.08546
26 Adherens_junction_hsa04520 3 72 0.05289 0.1058
27 Autophagy_animal_hsa04140 4 128 0.06442 0.1241
28 Endocytosis_hsa04144 6 244 0.06875 0.1277
29 Wnt_signaling_pathway_hsa04310 4 146 0.09365 0.1679
30 Regulation_of_actin_cytoskeleton_hsa04810 5 208 0.09922 0.172
31 mTOR_signaling_pathway_hsa04150 4 151 0.1027 0.1723
32 TNF_signaling_pathway_hsa04668 3 108 0.1344 0.2183
33 AMPK_signaling_pathway_hsa04152 3 121 0.1705 0.2687
34 p53_signaling_pathway_hsa04115 2 68 0.1903 0.291
35 Cellular_senescence_hsa04218 3 160 0.2905 0.4289
36 Jak_STAT_signaling_pathway_hsa04630 3 162 0.2969 0.4289
37 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.3073 0.4318
38 FoxO_signaling_pathway_hsa04068 2 132 0.4608 0.599
39 Cytokine_cytokine_receptor_interaction_hsa04060 3 270 0.6175 0.7831
40 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.8409 1

Quest ID: 2f129d4fbd62841e0bf69424d61a95f5