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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106b-5p AKT3 2.81 0 -3.33 1.0E-5 miRNATAP -0.41 1.0E-5 NA
2 hsa-miR-142-3p AKT3 4.35 0 -3.33 1.0E-5 miRanda -0.16 0.00934 NA
3 hsa-miR-15a-5p AKT3 2.05 0 -3.33 1.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.37 0.00021 NA
4 hsa-miR-15b-5p AKT3 3.32 0 -3.33 1.0E-5 miRNATAP -0.25 0.00571 NA
5 hsa-miR-16-5p AKT3 2.94 0 -3.33 1.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.31 0.00086 NA
6 hsa-miR-29b-3p AKT3 0.67 0.23406 -3.33 1.0E-5 miRNATAP -0.28 0.00031 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
7 hsa-miR-3065-5p AKT3 2.14 0.06094 -3.33 1.0E-5 mirMAP -0.22 0 NA
8 hsa-miR-362-3p AKT3 0.68 0.22615 -3.33 1.0E-5 miRanda -0.25 0.00124 NA
9 hsa-miR-501-3p AKT3 1.72 0.00759 -3.33 1.0E-5 miRNATAP -0.18 0.00733 NA
10 hsa-miR-93-5p AKT3 2.66 0 -3.33 1.0E-5 miRNATAP -0.33 0.00021 NA
11 hsa-miR-582-5p CHP2 0.69 0.44776 1.48 0.50956 miRNATAP -0.42 0.00313 NA
12 hsa-miR-130a-5p KDR 1.58 0.02435 -3.79 0 mirMAP -0.17 0.00459 NA
13 hsa-miR-149-5p KDR 1.19 0.19744 -3.79 0 miRNATAP -0.17 0.00011 NA
14 hsa-miR-15a-5p KDR 2.05 0 -3.79 0 miRNATAP -0.34 0.00024 NA
15 hsa-miR-15b-5p KDR 3.32 0 -3.79 0 miRNATAP -0.44 0 NA
16 hsa-miR-16-5p KDR 2.94 0 -3.79 0 miRTarBase; miRNATAP -0.49 0 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2
17 hsa-miR-19b-1-5p KDR 1.51 0.00147 -3.79 0 miRNAWalker2 validate -0.37 1.0E-5 NA
18 hsa-miR-200b-3p KDR 5.56 0 -3.79 0 miRNAWalker2 validate; miRTarBase; TargetScan -0.29 0 NA
19 hsa-miR-200c-3p KDR 6.47 0 -3.79 0 miRNATAP -0.38 0 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c
20 hsa-miR-3065-3p KDR 1.89 0.03082 -3.79 0 miRNATAP -0.15 0.00082 NA
21 hsa-miR-429 KDR 6.4 0 -3.79 0 PITA; miRanda; miRNATAP -0.25 0 NA
22 hsa-miR-590-3p KDR 2.35 0 -3.79 0 miRanda -0.29 0.00023 NA
23 hsa-miR-590-5p KDR 1.51 0.00239 -3.79 0 miRanda -0.23 0.00499 NA
24 hsa-miR-590-3p KRAS 2.35 0 0.4 0.26791 PITA; miRanda; mirMAP -0.1 0.00867 NA
25 hsa-miR-101-3p MAP2K1 -1.12 0.02009 0.52 0.11376 miRNAWalker2 validate -0.21 0 NA
26 hsa-miR-140-3p MAP2K1 -1.98 0 0.52 0.11376 PITA -0.13 0.00693 NA
27 hsa-miR-497-5p MAP2K1 -1.44 0.02251 0.52 0.11376 miRNAWalker2 validate -0.16 0 NA
28 hsa-miR-148b-3p MAPK1 1.76 0 0.01 0.9644 mirMAP -0.14 0.00442 NA
29 hsa-miR-29b-2-5p MAPK1 -0.6 0.18954 0.01 0.9644 mirMAP -0.15 2.0E-5 NA
30 hsa-miR-29c-3p MAPK1 -0.41 0.52934 0.01 0.9644 mirMAP -0.12 0 NA
31 hsa-miR-30b-5p MAPK1 0.02 0.95322 0.01 0.9644 mirMAP -0.11 0.00754 NA
32 hsa-miR-30e-5p MAPK1 0.78 0.03467 0.01 0.9644 mirMAP -0.12 0.00886 NA
33 hsa-miR-3913-5p MAPK1 0.15 0.73484 0.01 0.9644 mirMAP -0.11 0.0044 NA
34 hsa-miR-324-3p MAPKAPK2 1.51 0.00384 0.04 0.888 MirTarget -0.12 0.00014 NA
35 hsa-miR-148b-5p NFAT5 2.81 0 -0.87 0.01428 MirTarget -0.1 0.0096 NA
36 hsa-miR-15b-3p NFAT5 3.58 0 -0.87 0.01428 mirMAP -0.13 0.00043 NA
37 hsa-miR-16-1-3p NFAT5 2.83 0 -0.87 0.01428 mirMAP -0.13 0.00125 NA
38 hsa-miR-21-3p NFAT5 3.5 0 -0.87 0.01428 MirTarget -0.12 0.00062 NA
39 hsa-miR-25-3p NFAT5 1.13 0.00311 -0.87 0.01428 miRNATAP -0.22 3.0E-5 NA
40 hsa-miR-27b-5p NFAT5 0.21 0.71562 -0.87 0.01428 miRNATAP -0.11 0.00144 NA
41 hsa-miR-361-3p NFAT5 0.81 0.04185 -0.87 0.01428 MirTarget; PITA; miRNATAP -0.14 0.00508 NA
42 hsa-miR-3613-5p NFAT5 4.05 0 -0.87 0.01428 miRNATAP -0.1 0.00389 NA
43 hsa-miR-374a-3p NFAT5 0.47 0.30527 -0.87 0.01428 mirMAP -0.13 0.00396 NA
44 hsa-miR-16-2-3p NFATC2 3.8 0 -0.29 0.824 mirMAP -0.51 0.0002 NA
45 hsa-miR-182-5p NFATC2 5.87 0 -0.29 0.824 mirMAP -0.32 0.00065 NA
46 hsa-miR-19b-3p NFATC2 1.68 0.00086 -0.29 0.824 mirMAP -0.4 0.00522 NA
47 hsa-miR-221-3p NFATC2 0.94 0.17475 -0.29 0.824 MirTarget -0.38 0.00031 NA
48 hsa-miR-222-3p NFATC2 1.55 0.0223 -0.29 0.824 MirTarget -0.4 0.0002 NA
49 hsa-miR-2355-5p NFATC2 0.42 0.50215 -0.29 0.824 MirTarget -0.4 0.00064 NA
50 hsa-miR-24-3p NFATC2 1.56 0.00052 -0.29 0.824 MirTarget -0.47 0.00386 NA
51 hsa-miR-26b-3p NFATC2 0.99 0.03514 -0.29 0.824 MirTarget -0.42 0.00685 NA
52 hsa-miR-27b-5p NFATC2 0.21 0.71562 -0.29 0.824 mirMAP -0.56 1.0E-5 NA
53 hsa-miR-30b-5p NFATC2 0.02 0.95322 -0.29 0.824 MirTarget; mirMAP -0.7 0.0001 NA
54 hsa-miR-335-3p NFATC2 1.2 0.09389 -0.29 0.824 mirMAP -0.28 0.00699 NA
55 hsa-miR-33a-3p NFATC2 2.06 0.00156 -0.29 0.824 mirMAP -0.49 1.0E-5 NA
56 hsa-miR-3607-3p NFATC2 1.38 0.02401 -0.29 0.824 MirTarget; mirMAP -0.39 0.00099 NA
57 hsa-miR-590-3p NFATC2 2.35 0 -0.29 0.824 mirMAP -0.38 0.00751 NA
58 hsa-miR-9-5p NFATC2 1.8 0.14527 -0.29 0.824 MirTarget -0.18 0.00223 NA
59 hsa-miR-29a-3p NFATC3 -0.64 0.25192 0.48 0.1068 MirTarget; miRNATAP -0.14 0 NA
60 hsa-miR-30a-5p NFATC3 -0.77 0.32049 0.48 0.1068 MirTarget; miRNATAP -0.11 0 NA
61 hsa-miR-505-3p NFATC3 0.59 0.22694 0.48 0.1068 mirMAP -0.1 0.00323 NA
62 hsa-miR-15b-3p NFATC4 3.58 0 -3.51 3.0E-5 mirMAP -0.33 0.00011 NA
63 hsa-miR-193a-3p NFATC4 0.65 0.20713 -3.51 3.0E-5 miRanda -0.33 0.00048 NA
64 hsa-miR-2355-5p NFATC4 0.42 0.50215 -3.51 3.0E-5 MirTarget -0.22 0.0045 NA
65 hsa-miR-29b-3p NFATC4 0.67 0.23406 -3.51 3.0E-5 miRNATAP -0.27 0.00195 NA
66 hsa-miR-484 NFATC4 1.79 0.00022 -3.51 3.0E-5 MirTarget; miRNATAP -0.33 0.00085 NA
67 hsa-miR-629-3p NFATC4 3.48 0 -3.51 3.0E-5 mirMAP -0.45 0 NA
68 hsa-miR-429 NOS3 6.4 0 -3.31 0 miRanda -0.18 0.00014 NA
69 hsa-miR-26a-5p NRAS -0.35 0.36204 1.26 1.0E-5 mirMAP; miRNATAP -0.17 3.0E-5 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC
70 hsa-miR-28-5p NRAS -0.82 0.02212 1.26 1.0E-5 MirTarget; PITA; miRanda; miRNATAP -0.12 0.00589 NA
71 hsa-miR-29c-3p NRAS -0.41 0.52934 1.26 1.0E-5 miRNATAP -0.11 1.0E-5 NA
72 hsa-miR-148b-3p PIK3CA 1.76 0 0.51 0.24893 miRNAWalker2 validate -0.24 0.00148 NA
73 hsa-miR-186-5p PIK3CA 0.45 0.18545 0.51 0.24893 mirMAP -0.28 0.00023 NA
74 hsa-miR-29b-1-5p PIK3CA 0.34 0.59809 0.51 0.24893 mirMAP -0.12 0.00234 NA
75 hsa-miR-320b PIK3CA 0.2 0.72722 0.51 0.24893 miRanda -0.12 0.00551 NA
76 hsa-miR-335-5p PIK3CA 0.17 0.8039 0.51 0.24893 miRNAWalker2 validate -0.12 0.00088 NA
77 hsa-miR-338-5p PIK3CA -0.11 0.89468 0.51 0.24893 mirMAP -0.11 0.00047 NA
78 hsa-miR-339-5p PIK3CA 1.23 0.03075 0.51 0.24893 miRanda -0.14 0.00178 NA
79 hsa-miR-501-5p PIK3CA 1.04 0.07772 0.51 0.24893 mirMAP -0.12 0.00474 NA
80 hsa-miR-130a-3p PIK3CB 0.18 0.75775 0.9 0.01258 miRNATAP -0.12 0.00106 NA
81 hsa-miR-19b-3p PIK3CB 1.68 0.00086 0.9 0.01258 miRNATAP -0.11 0.00639 NA
82 hsa-miR-1468-5p PIK3CD -1.63 0.00779 0.06 0.92656 MirTarget -0.15 0.0056 NA
83 hsa-miR-199a-5p PIK3CD -1.25 0.07478 0.06 0.92656 MirTarget; PITA; miRanda; miRNATAP -0.16 0.00086 NA
84 hsa-miR-30d-5p PIK3CD 0.3 0.38019 0.06 0.92656 MirTarget; miRNATAP -0.27 0.00723 NA
85 hsa-miR-3913-5p PIK3CD 0.15 0.73484 0.06 0.92656 mirMAP -0.26 0.00117 NA
86 hsa-miR-335-3p PIK3CG 1.2 0.09389 -0.16 0.84867 mirMAP -0.29 1.0E-5 NA
87 hsa-miR-16-2-3p PIK3R1 3.8 0 -1.85 0.01274 MirTarget -0.22 0.0055 NA
88 hsa-miR-16-5p PIK3R1 2.94 0 -1.85 0.01274 MirTarget -0.23 0.00941 NA
89 hsa-miR-17-5p PIK3R1 2.33 2.0E-5 -1.85 0.01274 MirTarget; TargetScan; miRNATAP -0.26 0.00056 NA
90 hsa-miR-200c-3p PIK3R1 6.47 0 -1.85 0.01274 mirMAP -0.21 0.00097 NA
91 hsa-miR-29b-3p PIK3R1 0.67 0.23406 -1.85 0.01274 MirTarget; miRNATAP -0.23 0.00248 NA
92 hsa-miR-3065-5p PIK3R1 2.14 0.06094 -1.85 0.01274 MirTarget; mirMAP; miRNATAP -0.14 0.003 NA
93 hsa-miR-320c PIK3R1 -0.11 0.854 -1.85 0.01274 miRNATAP -0.24 0.00153 NA
94 hsa-miR-330-3p PIK3R1 2.49 0.00013 -1.85 0.01274 MirTarget; PITA; miRNATAP -0.22 0.00056 NA
95 hsa-miR-335-3p PIK3R1 1.2 0.09389 -1.85 0.01274 mirMAP -0.19 0.00155 NA
96 hsa-miR-338-5p PIK3R1 -0.11 0.89468 -1.85 0.01274 PITA -0.15 0.00415 NA
97 hsa-miR-582-5p PIK3R1 0.69 0.44776 -1.85 0.01274 mirMAP -0.17 0.00029 NA
98 hsa-miR-584-5p PIK3R1 1.18 0.20286 -1.85 0.01274 mirMAP -0.26 0 NA
99 hsa-miR-590-5p PIK3R1 1.51 0.00239 -1.85 0.01274 MirTarget; PITA; miRanda; miRNATAP -0.3 0.00045 NA
100 hsa-miR-629-3p PIK3R1 3.48 0 -1.85 0.01274 MirTarget -0.21 0.00106 NA
101 hsa-miR-1271-5p PIK3R3 0.21 0.74254 -0.03 0.95933 mirMAP -0.15 0.003 NA
102 hsa-miR-18a-3p PIK3R3 3.65 0 -0.03 0.95933 miRNAWalker2 validate -0.17 9.0E-5 NA
103 hsa-miR-222-5p PIK3R3 2.52 0.00142 -0.03 0.95933 mirMAP -0.17 4.0E-5 NA
104 hsa-miR-29b-1-5p PIK3R3 0.34 0.59809 -0.03 0.95933 mirMAP -0.21 3.0E-5 NA
105 hsa-miR-330-3p PIK3R3 2.49 0.00013 -0.03 0.95933 MirTarget -0.19 0.00014 NA
106 hsa-miR-330-5p PIK3R3 2.25 0.00028 -0.03 0.95933 miRanda -0.16 0.00263 NA
107 hsa-miR-365a-3p PIK3R3 0.26 0.65432 -0.03 0.95933 MirTarget -0.33 0 NA
108 hsa-miR-511-5p PIK3R3 1.1 0.17928 -0.03 0.95933 MirTarget -0.18 1.0E-5 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression
109 hsa-miR-590-5p PIK3R3 1.51 0.00239 -0.03 0.95933 miRanda -0.2 0.00312 NA
110 hsa-miR-125a-3p PIK3R5 -0.07 0.92074 0.76 0.28692 miRanda -0.14 0.00747 NA
111 hsa-miR-125a-5p PIK3R5 -1.32 0.00714 0.76 0.28692 MirTarget; miRanda -0.25 0.00223 NA
112 hsa-miR-182-5p PIK3R5 5.87 0 0.76 0.28692 MirTarget -0.25 0 NA
113 hsa-miR-142-3p PLA2G12A 4.35 0 -0.35 0.22836 miRanda -0.1 1.0E-5 NA
114 hsa-miR-142-5p PLA2G12A 3.96 0 -0.35 0.22836 mirMAP -0.13 0 NA
115 hsa-miR-491-5p PLA2G2A 0.57 0.31331 -3.35 0.08529 miRanda -0.56 0.00483 NA
116 hsa-miR-125a-5p PLA2G2F -1.32 0.00714 4.61 0.01694 mirMAP -1.06 0 NA
117 hsa-miR-125b-5p PLA2G2F -2.01 0.00516 4.61 0.01694 mirMAP -0.4 0.00804 NA
118 hsa-miR-324-3p PLA2G2F 1.51 0.00384 4.61 0.01694 mirMAP -0.66 0.00177 NA
119 hsa-miR-335-5p PLA2G2F 0.17 0.8039 4.61 0.01694 mirMAP -0.47 0.00403 NA
120 hsa-let-7e-5p PLA2G3 -0.11 0.81474 5.31 0.0047 MirTarget -0.84 0.00023 NA
121 hsa-miR-125a-3p PLA2G3 -0.07 0.92074 5.31 0.0047 miRanda; miRNATAP -0.51 0.00031 NA
122 hsa-miR-32-3p PLA2G3 2.2 0.03928 5.31 0.0047 miRNATAP -0.6 0.00065 NA
123 hsa-miR-590-3p PLA2G4A 2.35 0 -1.19 0.31842 miRanda -0.36 0.00732 NA
124 hsa-miR-2355-3p PLA2G6 0.49 0.48372 0.04 0.94425 MirTarget -0.22 0 NA
125 hsa-miR-125a-5p PLCG2 -1.32 0.00714 -1.09 0.05438 miRanda -0.18 0.00558 NA
126 hsa-miR-335-5p PLCG2 0.17 0.8039 -1.09 0.05438 miRNAWalker2 validate -0.2 3.0E-5 NA
127 hsa-let-7g-5p PPP3CA 0.86 0.00648 -0.1 0.76753 miRNATAP -0.16 0.0088 NA
128 hsa-miR-142-5p PRKCA 3.96 0 -2.51 0.0003 mirMAP -0.16 0.0045 NA
129 hsa-miR-183-5p PRKCA 6.62 0 -2.51 0.0003 miRNATAP -0.2 3.0E-5 NA
130 hsa-miR-200c-3p PRKCA 6.47 0 -2.51 0.0003 miRNATAP -0.23 0.00013 NA
131 hsa-miR-30e-3p PRKCA -0.04 0.93258 -2.51 0.0003 mirMAP -0.33 0.00043 NA
132 hsa-miR-330-3p PRKCA 2.49 0.00013 -2.51 0.0003 mirMAP -0.17 0.00423 NA
133 hsa-miR-340-5p PRKCA 1.41 0.00959 -2.51 0.0003 mirMAP -0.25 0.00068 NA
134 hsa-miR-374a-3p PRKCA 0.47 0.30527 -2.51 0.0003 mirMAP -0.32 0.00024 NA
135 hsa-miR-374a-5p PRKCA 0.28 0.45888 -2.51 0.0003 mirMAP -0.32 0.00335 NA
136 hsa-miR-590-3p PRKCA 2.35 0 -2.51 0.0003 PITA; miRanda; mirMAP; miRNATAP -0.34 1.0E-5 NA
137 hsa-miR-9-5p PRKCA 1.8 0.14527 -2.51 0.0003 miRNATAP -0.1 0.00143 NA
138 hsa-miR-944 PRKCA 7.21 0.00082 -2.51 0.0003 PITA; miRNATAP -0.16 0 NA
139 hsa-miR-129-5p PRKCB -2.67 0.00696 -1.38 0.12578 miRanda; mirMAP -0.15 0.00436 NA
140 hsa-miR-130a-5p PRKCB 1.58 0.02435 -1.38 0.12578 mirMAP -0.21 0.0041 NA
141 hsa-miR-141-5p PRKCB 7.14 0 -1.38 0.12578 mirMAP -0.19 0.00558 NA
142 hsa-miR-200b-3p PRKCB 5.56 0 -1.38 0.12578 MirTarget -0.3 2.0E-5 NA
143 hsa-miR-200c-3p PRKCB 6.47 0 -1.38 0.12578 MirTarget; miRNATAP -0.35 0 NA
144 hsa-miR-24-3p PRKCB 1.56 0.00052 -1.38 0.12578 miRNATAP -0.35 0.00216 NA
145 hsa-miR-30d-3p PRKCB -0.07 0.85742 -1.38 0.12578 mirMAP -0.47 0.00019 NA
146 hsa-miR-335-3p PRKCB 1.2 0.09389 -1.38 0.12578 mirMAP -0.32 1.0E-5 NA
147 hsa-miR-335-5p PRKCB 0.17 0.8039 -1.38 0.12578 mirMAP -0.26 0.00047 NA
148 hsa-miR-429 PRKCB 6.4 0 -1.38 0.12578 MirTarget; miRanda; miRNATAP -0.36 0 NA
149 hsa-miR-589-3p PRKCB 1.33 0.05263 -1.38 0.12578 mirMAP -0.26 0.00057 NA
150 hsa-miR-590-5p PRKCB 1.51 0.00239 -1.38 0.12578 miRanda -0.3 0.00345 NA
NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF RESPONSE TO STIMULUS 30 1929 6.224e-24 2.896e-20
2 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 16 323 2.384e-19 5.547e-16
3 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 11 74 9.091e-19 1.058e-15
4 FC RECEPTOR SIGNALING PATHWAY 14 206 7.534e-19 1.058e-15
5 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 26 1977 5.282e-18 4.915e-15
6 INTRACELLULAR SIGNAL TRANSDUCTION 24 1572 8.613e-18 6.679e-15
7 PLATELET ACTIVATION 12 142 2.364e-17 1.571e-14
8 GLYCEROLIPID BIOSYNTHETIC PROCESS 13 211 5.935e-17 3.452e-14
9 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 14 297 1.312e-16 6.781e-14
10 PHOSPHOLIPID BIOSYNTHETIC PROCESS 13 235 2.435e-16 1.133e-13
11 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 23 1656 5.153e-16 2.18e-13
12 ACTIVATION OF IMMUNE RESPONSE 15 427 6.759e-16 2.621e-13
13 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 12 193 1.005e-15 3.596e-13
14 GLYCEROLIPID METABOLIC PROCESS 14 356 1.633e-15 5.066e-13
15 FC EPSILON RECEPTOR SIGNALING PATHWAY 11 142 1.593e-15 5.066e-13
16 PHOSPHOLIPID METABOLIC PROCESS 14 364 2.222e-15 6.462e-13
17 REGULATION OF IMMUNE RESPONSE 18 858 3.04e-15 8.321e-13
18 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 18 867 3.643e-15 9.416e-13
19 REGULATION OF IMMUNE SYSTEM PROCESS 21 1403 4.582e-15 1.066e-12
20 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 18 876 4.356e-15 1.066e-12
21 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 15 498 6.509e-15 1.442e-12
22 POSITIVE REGULATION OF CELL COMMUNICATION 21 1532 2.63e-14 5.563e-12
23 POSITIVE REGULATION OF IMMUNE RESPONSE 15 563 3.911e-14 7.913e-12
24 CELL ACTIVATION 15 568 4.449e-14 8.625e-12
25 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 18 1036 7.826e-14 1.349e-11
26 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 18 1036 7.826e-14 1.349e-11
27 REGULATION OF PHOSPHORUS METABOLIC PROCESS 21 1618 7.738e-14 1.349e-11
28 FC GAMMA RECEPTOR SIGNALING PATHWAY 9 95 1.215e-13 2.019e-11
29 REGULATION OF BODY FLUID LEVELS 14 506 2.042e-13 3.277e-11
30 LOCOMOTION 18 1114 2.703e-13 4.192e-11
31 HEMOSTASIS 12 311 3.051e-13 4.58e-11
32 LIPID BIOSYNTHETIC PROCESS 14 539 4.817e-13 7.004e-11
33 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 15 689 7.284e-13 1.027e-10
34 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 13 450 1.035e-12 1.417e-10
35 VASCULATURE DEVELOPMENT 13 469 1.746e-12 2.321e-10
36 ERBB SIGNALING PATHWAY 8 79 1.83e-12 2.365e-10
37 CELLULAR LIPID METABOLIC PROCESS 16 913 2.701e-12 3.396e-10
38 PHOSPHATIDYLETHANOLAMINE ACYL CHAIN REMODELING 6 23 3.065e-12 3.753e-10
39 REGULATION OF KINASE ACTIVITY 15 776 4.004e-12 4.777e-10
40 IMMUNE SYSTEM PROCESS 21 1984 4.152e-12 4.83e-10
41 ANGIOGENESIS 11 293 4.685e-12 5.317e-10
42 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 17 1135 5.404e-12 5.987e-10
43 PHOSPHATIDYLCHOLINE ACYL CHAIN REMODELING 6 26 6.962e-12 7.533e-10
44 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 20 1805 7.928e-12 8.384e-10
45 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 7 55 9.457e-12 9.779e-10
46 CELL MOTILITY 15 835 1.136e-11 1.125e-09
47 LOCALIZATION OF CELL 15 835 1.136e-11 1.125e-09
48 PHOSPHORYLATION 17 1228 1.888e-11 1.83e-09
49 PHOSPHATIDYLGLYCEROL METABOLIC PROCESS 6 31 2.211e-11 2.1e-09
50 REGULATION OF RESPONSE TO STRESS 18 1468 2.811e-11 2.616e-09
51 TAXIS 12 464 3.308e-11 3.018e-09
52 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 17 1275 3.416e-11 3.057e-09
53 POSITIVE REGULATION OF MAPK CASCADE 12 470 3.839e-11 3.248e-09
54 WOUND HEALING 12 470 3.839e-11 3.248e-09
55 LEUKOCYTE MIGRATION 10 259 3.833e-11 3.248e-09
56 BLOOD VESSEL MORPHOGENESIS 11 364 4.841e-11 4.022e-09
57 POSITIVE REGULATION OF KINASE ACTIVITY 12 482 5.137e-11 4.194e-09
58 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 8 120 5.58e-11 4.457e-09
59 IMMUNE EFFECTOR PROCESS 12 486 5.652e-11 4.457e-09
60 PROTEIN PHOSPHORYLATION 15 944 6.427e-11 4.984e-09
61 REGULATION OF TRANSFERASE ACTIVITY 15 946 6.621e-11 5.027e-09
62 PHAGOCYTOSIS 9 190 6.698e-11 5.027e-09
63 REGULATION OF TRANSPORT 19 1804 8.496e-11 6.275e-09
64 REGULATION OF LIPID METABOLIC PROCESS 10 282 8.84e-11 6.427e-09
65 LIPID METABOLIC PROCESS 16 1158 9.552e-11 6.837e-09
66 RESPONSE TO EXTERNAL STIMULUS 19 1821 9.994e-11 7.046e-09
67 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 6 40 1.139e-10 7.843e-09
68 PHOSPHATIDYLGLYCEROL ACYL CHAIN REMODELING 5 17 1.146e-10 7.843e-09
69 POSITIVE REGULATION OF MAP KINASE ACTIVITY 9 207 1.439e-10 9.707e-09
70 POSITIVE REGULATION OF LOCOMOTION 11 420 2.223e-10 1.477e-08
71 RESPONSE TO WOUNDING 12 563 3.061e-10 2.006e-08
72 REGULATION OF CELL MATRIX ADHESION 7 90 3.32e-10 2.146e-08
73 REGULATION OF PROTEIN MODIFICATION PROCESS 18 1710 3.475e-10 2.215e-08
74 ORGANOPHOSPHATE METABOLIC PROCESS 14 885 3.575e-10 2.234e-08
75 REGULATION OF LIPID KINASE ACTIVITY 6 48 3.6e-10 2.234e-08
76 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 17 1492 3.992e-10 2.444e-08
77 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 6 49 4.097e-10 2.476e-08
78 POSITIVE REGULATION OF MOLECULAR FUNCTION 18 1791 7.385e-10 4.405e-08
79 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 12 616 8.528e-10 5.023e-08
80 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 25 9.734e-10 5.661e-08
81 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 14 957 9.902e-10 5.688e-08
82 REGULATION OF CELL SUBSTRATE ADHESION 8 173 1.044e-09 5.927e-08
83 REGULATION OF CELL ADHESION 12 629 1.081e-09 5.949e-08
84 CARDIOVASCULAR SYSTEM DEVELOPMENT 13 788 1.087e-09 5.949e-08
85 CIRCULATORY SYSTEM DEVELOPMENT 13 788 1.087e-09 5.949e-08
86 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 6 61 1.6e-09 8.658e-08
87 ENDOCYTOSIS 11 509 1.684e-09 9.008e-08
88 REGULATION OF MAPK CASCADE 12 660 1.862e-09 9.847e-08
89 PHOSPHATIDYLCHOLINE METABOLIC PROCESS 6 64 2.152e-09 1.125e-07
90 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 8 195 2.692e-09 1.392e-07
91 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 9 289 2.739e-09 1.401e-07
92 REGULATION OF CELL DEATH 16 1472 3.215e-09 1.626e-07
93 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 9 296 3.376e-09 1.689e-07
94 REGULATION OF MAP KINASE ACTIVITY 9 319 6.481e-09 3.208e-07
95 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 7 138 6.745e-09 3.303e-07
96 HOMEOSTATIC PROCESS 15 1337 7.875e-09 3.817e-07
97 ERBB2 SIGNALING PATHWAY 5 39 1.035e-08 4.938e-07
98 REGULATION OF VESICLE MEDIATED TRANSPORT 10 462 1.04e-08 4.938e-07
99 ETHANOLAMINE CONTAINING COMPOUND METABOLIC PROCESS 6 85 1.22e-08 5.677e-07
100 RESPONSE TO OXYGEN CONTAINING COMPOUND 15 1381 1.22e-08 5.677e-07
101 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 15 1395 1.398e-08 6.44e-07
102 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 12 799 1.582e-08 7.215e-07
103 PHOSPHATIDYLINOSITOL ACYL CHAIN REMODELING 4 16 1.983e-08 8.959e-07
104 POSITIVE REGULATION OF DEFENSE RESPONSE 9 364 2.031e-08 9.088e-07
105 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 13 1021 2.435e-08 1.079e-06
106 PHOSPHATIDYLSERINE ACYL CHAIN REMODELING 4 17 2.59e-08 1.137e-06
107 VESICLE MEDIATED TRANSPORT 14 1239 2.702e-08 1.175e-06
108 LIPID PHOSPHORYLATION 6 99 3.065e-08 1.321e-06
109 REGULATION OF CELL PROLIFERATION 15 1496 3.57e-08 1.524e-06
110 REGULATION OF ADHERENS JUNCTION ORGANIZATION 5 50 3.75e-08 1.586e-06
111 POSITIVE REGULATION OF CATALYTIC ACTIVITY 15 1518 4.337e-08 1.818e-06
112 CELLULAR RESPONSE TO GROWTH HORMONE STIMULUS 4 20 5.251e-08 2.181e-06
113 B CELL RECEPTOR SIGNALING PATHWAY 5 54 5.567e-08 2.292e-06
114 SINGLE ORGANISM BIOSYNTHETIC PROCESS 14 1340 7.222e-08 2.948e-06
115 ENDOTHELIAL CELL MIGRATION 5 57 7.341e-08 2.97e-06
116 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 16 1848 8.184e-08 3.283e-06
117 INOSITOL LIPID MEDIATED SIGNALING 6 124 1.18e-07 4.694e-06
118 REGULATION OF CELLULAR COMPONENT MOVEMENT 11 771 1.208e-07 4.762e-06
119 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 6 128 1.426e-07 5.574e-06
120 AMINE METABOLIC PROCESS 6 131 1.636e-07 6.343e-06
121 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 6 133 1.79e-07 6.815e-06
122 REGULATION OF CELL JUNCTION ASSEMBLY 5 68 1.8e-07 6.815e-06
123 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 9 470 1.802e-07 6.815e-06
124 POSITIVE REGULATION OF CELL PROLIFERATION 11 814 2.085e-07 7.823e-06
125 PHOSPHATIDYLSERINE METABOLIC PROCESS 4 28 2.195e-07 8.17e-06
126 REGULATION OF CELL ACTIVATION 9 484 2.308e-07 8.524e-06
127 POSITIVE REGULATION OF GENE EXPRESSION 15 1733 2.487e-07 9.113e-06
128 REGULATION OF CELL DIFFERENTIATION 14 1492 2.732e-07 9.93e-06
129 RESPONSE TO GROWTH HORMONE 4 30 2.93e-07 1.057e-05
130 T CELL RECEPTOR SIGNALING PATHWAY 6 146 3.108e-07 1.113e-05
131 CELLULAR RESPONSE TO NITROGEN COMPOUND 9 505 3.3e-07 1.172e-05
132 PEPTIDYL SERINE MODIFICATION 6 148 3.368e-07 1.187e-05
133 RESPONSE TO NITROGEN COMPOUND 11 859 3.57e-07 1.249e-05
134 REGULATION OF RECEPTOR MEDIATED ENDOCYTOSIS 5 78 3.596e-07 1.249e-05
135 LIPID CATABOLIC PROCESS 7 247 3.665e-07 1.263e-05
136 NEGATIVE REGULATION OF CELL DEATH 11 872 4.146e-07 1.419e-05
137 PHOSPHATIDIC ACID METABOLIC PROCESS 4 33 4.357e-07 1.48e-05
138 REGULATION OF CELL CELL ADHESION 8 380 4.688e-07 1.581e-05
139 RESPONSE TO BACTERIUM 9 528 4.795e-07 1.605e-05
140 TISSUE MIGRATION 5 84 5.215e-07 1.733e-05
141 SECOND MESSENGER MEDIATED SIGNALING 6 160 5.331e-07 1.759e-05
142 ALDITOL PHOSPHATE METABOLIC PROCESS 4 35 5.56e-07 1.822e-05
143 REGULATION OF EPITHELIAL CELL MIGRATION 6 166 6.616e-07 2.153e-05
144 MULTICELLULAR ORGANISMAL HOMEOSTASIS 7 272 7.011e-07 2.265e-05
145 AMMONIUM ION METABOLIC PROCESS 6 169 7.349e-07 2.331e-05
146 CALCIUM MEDIATED SIGNALING 5 90 7.363e-07 2.331e-05
147 CELLULAR RESPONSE TO PEPTIDE 7 274 7.364e-07 2.331e-05
148 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 11 926 7.521e-07 2.365e-05
149 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 12 1142 7.684e-07 2.4e-05
150 TISSUE HOMEOSTASIS 6 171 7.873e-07 2.442e-05
151 REPRODUCTIVE SYSTEM DEVELOPMENT 8 408 8.014e-07 2.469e-05
152 POSITIVE REGULATION OF TRANSPORT 11 936 8.362e-07 2.543e-05
153 ACTIVATION OF PROTEIN KINASE ACTIVITY 7 279 8.313e-07 2.543e-05
154 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 12 1152 8.429e-07 2.547e-05
155 REGULATION OF DEFENSE RESPONSE 10 759 1.052e-06 3.158e-05
156 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 9 602 1.427e-06 4.256e-05
157 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 5 103 1.441e-06 4.269e-05
158 REGULATION OF HOMOTYPIC CELL CELL ADHESION 7 307 1.574e-06 4.634e-05
159 RESPONSE TO ABIOTIC STIMULUS 11 1024 2.017e-06 5.902e-05
160 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 7 321 2.116e-06 6.153e-05
161 NEURON PROJECTION GUIDANCE 6 205 2.264e-06 6.542e-05
162 REGULATION OF ENDOTHELIAL CELL MIGRATION 5 114 2.379e-06 6.834e-05
163 LIPID MODIFICATION 6 210 2.602e-06 7.429e-05
164 REGULATION OF CYTOPLASMIC TRANSPORT 8 481 2.738e-06 7.769e-05
165 CYTOKINE PRODUCTION 5 120 3.064e-06 8.639e-05
166 CELLULAR RESPONSE TO STRESS 13 1565 3.313e-06 9.287e-05
167 REGULATION OF EARLY ENDOSOME TO LATE ENDOSOME TRANSPORT 3 16 3.484e-06 9.706e-05
168 ALCOHOL METABOLIC PROCESS 7 348 3.607e-06 9.991e-05
169 CELLULAR HOMEOSTASIS 9 676 3.695e-06 0.0001017
170 CHEMICAL HOMEOSTASIS 10 874 3.738e-06 0.0001023
171 NEGATIVE REGULATION OF ANOIKIS 3 17 4.225e-06 0.000115
172 RESPONSE TO HORMONE 10 893 4.526e-06 0.0001224
173 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 59 4.677e-06 0.0001258
174 REGULATION OF VASCULATURE DEVELOPMENT 6 233 4.738e-06 0.0001267
175 OVULATION 3 18 5.063e-06 0.0001331
176 MAST CELL MEDIATED IMMUNITY 3 18 5.063e-06 0.0001331
177 INOSITOL PHOSPHATE MEDIATED SIGNALING 3 18 5.063e-06 0.0001331
178 POSITIVE REGULATION OF CELL ADHESION 7 376 5.995e-06 0.0001567
179 PLACENTA DEVELOPMENT 5 138 6.078e-06 0.000158
180 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 13 1672 6.876e-06 0.0001777
181 REGULATION OF CELL MORPHOGENESIS 8 552 7.54e-06 0.0001938
182 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 4 67 7.792e-06 0.0001981
183 REGULATION OF ORGANELLE ORGANIZATION 11 1178 7.777e-06 0.0001981
184 MAST CELL ACTIVATION 3 21 8.22e-06 0.0002045
185 REGULATION OF CELL PROJECTION ORGANIZATION 8 558 8.159e-06 0.0002045
186 POSITIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 3 21 8.22e-06 0.0002045
187 BONE RESORPTION 3 21 8.22e-06 0.0002045
188 SINGLE ORGANISM CATABOLIC PROCESS 10 957 8.341e-06 0.0002064
189 RESPONSE TO ENDOGENOUS STIMULUS 12 1450 9.256e-06 0.0002279
190 RESPONSE TO PEPTIDE 7 404 9.576e-06 0.0002321
191 CELLULAR CHEMICAL HOMEOSTASIS 8 570 9.527e-06 0.0002321
192 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 7 404 9.576e-06 0.0002321
193 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 8 573 9.898e-06 0.0002386
194 REGULATION OF CELLULAR COMPONENT BIOGENESIS 9 767 1.026e-05 0.0002461
195 AMEBOIDAL TYPE CELL MIGRATION 5 154 1.037e-05 0.0002474
196 LYSOSOME LOCALIZATION 3 23 1.092e-05 0.0002578
197 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 3 23 1.092e-05 0.0002578
198 IMMUNE SYSTEM DEVELOPMENT 8 582 1.109e-05 0.0002592
199 REGULATION OF RESPONSE TO WOUNDING 7 413 1.105e-05 0.0002592
200 LEUKOCYTE ACTIVATION 7 414 1.122e-05 0.0002611
201 DEFENSE RESPONSE 11 1231 1.181e-05 0.0002733
202 POSITIVE REGULATION OF CELL JUNCTION ASSEMBLY 3 24 1.246e-05 0.0002842
203 REGULATION OF ANOIKIS 3 24 1.246e-05 0.0002842
204 POSITIVE REGULATION OF LAMELLIPODIUM ORGANIZATION 3 24 1.246e-05 0.0002842
205 VASCULAR PROCESS IN CIRCULATORY SYSTEM 5 163 1.366e-05 0.0003099
206 POSITIVE REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 3 25 1.414e-05 0.0003194
207 LYMPHOCYTE COSTIMULATION 4 78 1.429e-05 0.0003211
208 TISSUE DEVELOPMENT 12 1518 1.474e-05 0.0003298
209 ANATOMICAL STRUCTURE HOMEOSTASIS 6 285 1.495e-05 0.0003328
210 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 4 81 1.659e-05 0.0003677
211 REGULATION OF CELLULAR LOCALIZATION 11 1277 1.668e-05 0.0003678
212 POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE 5 172 1.77e-05 0.0003871
213 REGULATION OF INTRACELLULAR TRANSPORT 8 621 1.772e-05 0.0003871
214 RESPONSE TO LITHIUM ION 3 27 1.794e-05 0.00039
215 REGULATION OF HOMEOSTATIC PROCESS 7 447 1.842e-05 0.0003986
216 POSITIVE REGULATION OF ACUTE INFLAMMATORY RESPONSE 3 28 2.006e-05 0.0004321
217 INFLAMMATORY RESPONSE 7 454 2.036e-05 0.0004345
218 MODULATION OF SYNAPTIC TRANSMISSION 6 301 2.035e-05 0.0004345
219 PEPTIDYL AMINO ACID MODIFICATION 9 841 2.138e-05 0.0004542
220 SINGLE ORGANISM CELL ADHESION 7 459 2.184e-05 0.0004619
221 TISSUE REMODELING 4 87 2.202e-05 0.0004636
222 REGULATION OF VACUOLAR TRANSPORT 3 29 2.235e-05 0.0004684
223 LEUKOCYTE DEGRANULATION 3 30 2.48e-05 0.0005151
224 CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 3 30 2.48e-05 0.0005151
225 RESPONSE TO GROWTH FACTOR 7 475 2.72e-05 0.0005624
226 RESPONSE TO INORGANIC SUBSTANCE 7 479 2.869e-05 0.0005908
227 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 7 482 2.986e-05 0.0006121
228 POSITIVE REGULATION OF LIPID KINASE ACTIVITY 3 32 3.021e-05 0.0006166
229 ICOSANOID METABOLIC PROCESS 4 96 3.246e-05 0.0006483
230 FEMALE GAMETE GENERATION 4 96 3.246e-05 0.0006483
231 RESPONSE TO BIOTIC STIMULUS 9 886 3.224e-05 0.0006483
232 REGULATION OF MUSCLE SYSTEM PROCESS 5 195 3.235e-05 0.0006483
233 FATTY ACID DERIVATIVE METABOLIC PROCESS 4 96 3.246e-05 0.0006483
234 RESPIRATORY SYSTEM DEVELOPMENT 5 197 3.397e-05 0.0006754
235 REGULATION OF ENDOCYTOSIS 5 199 3.565e-05 0.0007058
236 RESPONSE TO FLUID SHEAR STRESS 3 34 3.636e-05 0.0007168
237 MYELOID LEUKOCYTE MIGRATION 4 99 3.664e-05 0.0007193
238 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 337 3.835e-05 0.0007497
239 BONE REMODELING 3 35 3.971e-05 0.0007732
240 ACTIVATION OF INNATE IMMUNE RESPONSE 5 204 4.013e-05 0.000778
241 LYMPHOCYTE ACTIVATION 6 342 4.163e-05 0.0008037
242 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 7 513 4.439e-05 0.0008511
243 POSITIVE REGULATION OF PROTEIN IMPORT 4 104 4.445e-05 0.0008511
244 REGULATION OF CALCIUM ION TRANSPORT 5 209 4.504e-05 0.0008553
245 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 7 514 4.494e-05 0.0008553
246 CELL DEVELOPMENT 11 1426 4.647e-05 0.0008789
247 REGULATION OF LAMELLIPODIUM ORGANIZATION 3 37 4.702e-05 0.0008858
248 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 4 106 4.789e-05 0.0008986
249 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 6 360 5.536e-05 0.001026
250 ASTROCYTE DIFFERENTIATION 3 39 5.516e-05 0.001026
251 REGULATION OF PROTEIN LOCALIZATION 9 950 5.558e-05 0.001026
252 PEPTIDYL TYROSINE AUTOPHOSPHORYLATION 3 39 5.516e-05 0.001026
253 POSITIVE REGULATION OF CELL MATRIX ADHESION 3 40 5.956e-05 0.001095
254 CIRCULATORY SYSTEM PROCESS 6 366 6.067e-05 0.001111
255 POSITIVE REGULATION OF INFLAMMATORY RESPONSE 4 113 6.149e-05 0.001122
256 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 6 368 6.253e-05 0.001137
257 MYELOID CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 3 41 6.417e-05 0.001162
258 POSITIVE REGULATION OF CYTOKINE PRODUCTION 6 370 6.443e-05 0.001162
259 SMALL MOLECULE METABOLIC PROCESS 12 1767 6.674e-05 0.001199
260 POSITIVE REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 3 42 6.902e-05 0.001235
261 LEUKOCYTE CHEMOTAXIS 4 117 7.041e-05 0.001247
262 CELLULAR RESPONSE TO HORMONE STIMULUS 7 552 7.048e-05 0.001247
263 TUBE DEVELOPMENT 7 552 7.048e-05 0.001247
264 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 5 232 7.389e-05 0.001301
265 MYELOID LEUKOCYTE MEDIATED IMMUNITY 3 43 7.41e-05 0.001301
266 POSITIVE REGULATION OF CHEMOTAXIS 4 120 7.77e-05 0.001359
267 REGULATION OF CYTOKINE PRODUCTION 7 563 7.977e-05 0.001388
268 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 4 121 8.025e-05 0.001388
269 REGULATION OF PROTEIN KINASE B SIGNALING 4 121 8.025e-05 0.001388
270 MUSCLE CELL DIFFERENTIATION 5 237 8.172e-05 0.001408
271 CELL DEATH 9 1001 8.324e-05 0.001426
272 REGULATION OF ERK1 AND ERK2 CASCADE 5 238 8.336e-05 0.001426
273 LUNG MORPHOGENESIS 3 45 8.498e-05 0.001448
274 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 9 1008 8.782e-05 0.001491
275 PEPTIDYL THREONINE MODIFICATION 3 46 9.079e-05 0.001536
276 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 5 246 9.74e-05 0.001642
277 MUSCLE CELL DEVELOPMENT 4 128 9.982e-05 0.001677
278 NEURON PROJECTION MORPHOGENESIS 6 402 0.0001017 0.001703
279 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 4 129 0.0001029 0.001716
280 BIOLOGICAL ADHESION 9 1032 0.0001052 0.001748
281 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 6 406 0.0001074 0.001779
282 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 4 131 0.0001092 0.001802
283 B CELL ACTIVATION 4 132 0.0001124 0.001844
284 REPRODUCTION 10 1297 0.0001126 0.001844
285 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 5 258 0.0001218 0.001988
286 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 3 51 0.0001237 0.002006
287 REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 3 51 0.0001237 0.002006
288 POSITIVE REGULATION OF CELL DIFFERENTIATION 8 823 0.0001295 0.00209
289 ACTIVATION OF MAPK ACTIVITY 4 137 0.0001298 0.00209
290 CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 4 139 0.0001373 0.002203
291 REGULATION OF SYNAPTIC PLASTICITY 4 140 0.0001411 0.002256
292 CELL PART MORPHOGENESIS 7 633 0.0001652 0.002633
293 CELLULAR RESPONSE TO INSULIN STIMULUS 4 146 0.0001659 0.002634
294 POSITIVE REGULATION OF TUMOR NECROSIS FACTOR SUPERFAMILY CYTOKINE PRODUCTION 3 57 0.0001725 0.00273
295 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 5 282 0.0001844 0.002899
296 MUSCLE SYSTEM PROCESS 5 282 0.0001844 0.002899
297 POSITIVE REGULATION OF ENDOTHELIAL CELL CHEMOTAXIS 2 11 0.0001913 0.002966
298 CHEMICAL HOMEOSTASIS WITHIN A TISSUE 2 11 0.0001913 0.002966
299 REGULATION OF FEVER GENERATION 2 11 0.0001913 0.002966
300 VASCULOGENESIS 3 59 0.0001911 0.002966
301 MATERNAL PROCESS INVOLVED IN FEMALE PREGNANCY 3 60 0.0002009 0.003106
302 LEUKOCYTE DIFFERENTIATION 5 292 0.0002168 0.003341
303 RESPONSE TO LIPID 8 888 0.0002183 0.003353
304 REGULATION OF GOLGI ORGANIZATION 2 12 0.0002292 0.003474
305 EMBRYO DEVELOPMENT 8 894 0.0002286 0.003474
306 TRACHEA MORPHOGENESIS 2 12 0.0002292 0.003474
307 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 2 12 0.0002292 0.003474
308 REGULATION OF MUSCLE ADAPTATION 3 63 0.0002323 0.003509
309 CELL PROLIFERATION 7 672 0.0002385 0.003591
310 CELLULAR COMPONENT MORPHOGENESIS 8 900 0.0002392 0.003591
311 CELL PROJECTION ORGANIZATION 8 902 0.0002429 0.003633
312 CELL CHEMOTAXIS 4 162 0.000247 0.003672
313 POSITIVE REGULATION OF RESPONSE TO WOUNDING 4 162 0.000247 0.003672
314 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 303 0.0002573 0.003812
315 CELLULAR RESPONSE TO UV 3 66 0.0002666 0.003926
316 POSITIVE REGULATION OF LIPID BIOSYNTHETIC PROCESS 3 66 0.0002666 0.003926
317 LIPOXYGENASE PATHWAY 2 13 0.0002706 0.003972
318 REGULATION OF PROTEIN TARGETING 5 307 0.0002733 0.003999
319 MORPHOGENESIS OF A BRANCHING STRUCTURE 4 167 0.0002774 0.004046
320 RESPONSE TO CARBOHYDRATE 4 168 0.0002838 0.004126
321 POSITIVE REGULATION OF CELL ACTIVATION 5 311 0.0002901 0.004205
322 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 3 68 0.0002912 0.004208
323 REGULATION OF RESPIRATORY BURST 2 14 0.0003153 0.004459
324 VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING PATHWAY 2 14 0.0003153 0.004459
325 REGULATION OF FIBROBLAST APOPTOTIC PROCESS 2 14 0.0003153 0.004459
326 T CELL MIGRATION 2 14 0.0003153 0.004459
327 CARDIOLIPIN METABOLIC PROCESS 2 14 0.0003153 0.004459
328 REGULATION OF PROTEIN KINASE C SIGNALING 2 14 0.0003153 0.004459
329 POSITIVE REGULATION OF SPROUTING ANGIOGENESIS 2 14 0.0003153 0.004459
330 STRIATED MUSCLE CELL DIFFERENTIATION 4 173 0.0003173 0.004473
331 EPITHELIUM DEVELOPMENT 8 945 0.0003328 0.004679
332 RESPONSE TO CORTICOSTEROID 4 176 0.0003387 0.004746
333 SYSTEM PROCESS 11 1785 0.0003455 0.004828
334 REGULATION OF METAL ION TRANSPORT 5 325 0.0003551 0.004947
335 REGULATION OF SYSTEM PROCESS 6 507 0.000357 0.004958
336 CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 2 15 0.0003634 0.004973
337 REGULATION OF HEAT GENERATION 2 15 0.0003634 0.004973
338 NEGATIVE REGULATION OF DENDRITE MORPHOGENESIS 2 15 0.0003634 0.004973
339 RESPIRATORY BURST 2 15 0.0003634 0.004973
340 REGULATION OF HYDROGEN PEROXIDE METABOLIC PROCESS 2 15 0.0003634 0.004973
341 REGULATION OF CHEMOTAXIS 4 180 0.0003688 0.005032
342 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 3 74 0.0003737 0.00507
343 REGULATION OF ACUTE INFLAMMATORY RESPONSE 3 74 0.0003737 0.00507
344 GRANULOCYTE MIGRATION 3 75 0.0003888 0.005244
345 CELLULAR GLUCOSE HOMEOSTASIS 3 75 0.0003888 0.005244
346 REGULATION OF PROTEIN IMPORT 4 183 0.0003926 0.00528
347 RESPONSE TO METAL ION 5 333 0.0003969 0.005323
348 POSITIVE REGULATION OF LAMELLIPODIUM ASSEMBLY 2 16 0.0004148 0.00553
349 POSITIVE REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 16 0.0004148 0.00553
350 PEPTIDYL TYROSINE MODIFICATION 4 186 0.0004175 0.005551
351 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 8 983 0.0004336 0.005749
352 DIVALENT INORGANIC CATION HOMEOSTASIS 5 343 0.0004543 0.006006
353 REGULATION OF CHROMATIN BINDING 2 17 0.0004695 0.006067
354 POSITIVE REGULATION OF FATTY ACID BIOSYNTHETIC PROCESS 2 17 0.0004695 0.006067
355 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 2 17 0.0004695 0.006067
356 REGULATION OF CALCINEURIN NFAT SIGNALING CASCADE 2 17 0.0004695 0.006067
357 INSULIN RECEPTOR SIGNALING PATHWAY 3 80 0.00047 0.006067
358 REGULATION OF ENDOTHELIAL CELL CHEMOTAXIS 2 17 0.0004695 0.006067
359 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 2 17 0.0004695 0.006067
360 PROTEIN AUTOPHOSPHORYLATION 4 192 0.0004707 0.006067
361 RESPONSE TO REACTIVE OXYGEN SPECIES 4 191 0.0004615 0.006067
362 POSITIVE REGULATION OF LEUKOCYTE CHEMOTAXIS 3 81 0.0004874 0.006265
363 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 8 1004 0.0004993 0.0064
364 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 5 352 0.0005112 0.006517
365 RESPONSE TO OXIDATIVE STRESS 5 352 0.0005112 0.006517
366 NEURON PROJECTION DEVELOPMENT 6 545 0.0005237 0.006658
367 REGULATION OF MITOCHONDRIAL DEPOLARIZATION 2 18 0.0005276 0.006689
368 NUCLEAR TRANSPORT 5 355 0.0005313 0.006717
369 MULTICELLULAR ORGANISM REPRODUCTION 7 768 0.0005341 0.006735
370 REGULATION OF INNATE IMMUNE RESPONSE 5 357 0.000545 0.006854
371 EPHRIN RECEPTOR SIGNALING PATHWAY 3 85 0.0005613 0.007021
372 REGULATION OF CELLULAR PROTEIN LOCALIZATION 6 552 0.0005601 0.007021
373 REGULATION OF NEURON DIFFERENTIATION 6 554 0.0005709 0.007121
374 CELLULAR RESPONSE TO FLUID SHEAR STRESS 2 19 0.000589 0.007308
375 REGULATION OF CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 2 19 0.000589 0.007308
376 RESPONSE TO INSULIN 4 205 0.0006022 0.007437
377 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 5 365 0.0006026 0.007437
378 OVULATION CYCLE PROCESS 3 88 0.0006212 0.007646
379 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 5 370 0.0006408 0.007861
380 EPITHELIAL CELL PROLIFERATION 3 89 0.000642 0.007861
381 EMBRYONIC HEMOPOIESIS 2 20 0.0006536 0.007961
382 TRACHEA DEVELOPMENT 2 20 0.0006536 0.007961
383 CELLULAR RESPONSE TO LIGHT STIMULUS 3 91 0.000685 0.008322
384 DECIDUALIZATION 2 21 0.0007216 0.008743
385 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 4 216 0.0007324 0.008806
386 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 5 381 0.0007313 0.008806
387 POSITIVE REGULATION OF BLOOD CIRCULATION 3 93 0.0007298 0.008806
388 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 4 218 0.000758 0.00909
389 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 3 95 0.0007764 0.009263
390 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 3 95 0.0007764 0.009263
391 NEGATIVE REGULATION OF MUSCLE CONTRACTION 2 22 0.0007928 0.009291
392 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 4 220 0.0007843 0.009291
393 POSITIVE REGULATION OF MUSCLE HYPERTROPHY 2 22 0.0007928 0.009291
394 POSITIVE REGULATION OF PROTEIN AUTOPHOSPHORYLATION 2 22 0.0007928 0.009291
395 CELLULAR MODIFIED AMINO ACID METABOLIC PROCESS 4 220 0.0007843 0.009291
396 POSITIVE REGULATION OF CARDIAC MUSCLE HYPERTROPHY 2 22 0.0007928 0.009291
397 ERK1 AND ERK2 CASCADE 2 22 0.0007928 0.009291
398 MYELOID LEUKOCYTE DIFFERENTIATION 3 96 0.0008004 0.00931
399 REGULATION OF PROTEIN STABILITY 4 221 0.0007977 0.00931
400 REGULATION OF LEUKOCYTE CHEMOTAXIS 3 96 0.0008004 0.00931
401 NEGATIVE REGULATION OF CELL ADHESION 4 223 0.0008249 0.009572
402 REGULATED EXOCYTOSIS 4 224 0.0008388 0.009708
403 MYELOID LEUKOCYTE ACTIVATION 3 98 0.0008498 0.009787
404 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 3 98 0.0008498 0.009787
405 GLAND DEVELOPMENT 5 395 0.00086 0.00988
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 16 842 7.893e-13 7.333e-10
2 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 16 992 9.455e-12 4.392e-09
3 PHOSPHOLIPASE A2 ACTIVITY 6 31 2.211e-11 6.847e-09
4 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 70 5.474e-11 1.271e-08
5 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 6 43 1.801e-10 3.346e-08
6 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 6 51 5.262e-10 6.984e-08
7 PHOSPHOLIPASE ACTIVITY 7 94 4.524e-10 6.984e-08
8 RIBONUCLEOTIDE BINDING 18 1860 1.363e-09 1.582e-07
9 LIPASE ACTIVITY 7 117 2.124e-09 2.193e-07
10 PROTEIN KINASE ACTIVITY 11 640 1.812e-08 1.675e-06
11 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 4 16 1.983e-08 1.675e-06
12 CARBOXYLIC ESTER HYDROLASE ACTIVITY 6 135 1.956e-07 1.514e-05
13 INSULIN RECEPTOR SUBSTRATE BINDING 3 11 1.033e-06 7.383e-05
14 KINASE BINDING 9 606 1.507e-06 8.391e-05
15 KINASE REGULATOR ACTIVITY 6 186 1.287e-06 8.391e-05
16 CALCIUM DEPENDENT PROTEIN KINASE ACTIVITY 3 12 1.376e-06 8.391e-05
17 PROTEIN SERINE THREONINE KINASE ACTIVITY 8 445 1.536e-06 8.391e-05
18 ADENYL NUCLEOTIDE BINDING 13 1514 2.29e-06 0.0001182
19 HYDROLASE ACTIVITY ACTING ON ESTER BONDS 9 739 7.609e-06 0.000372
20 ENZYME BINDING 13 1737 1.043e-05 0.0004845
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 3.789e-15 2.213e-12
2 EXTRINSIC COMPONENT OF MEMBRANE 11 252 9.105e-13 2.659e-10
3 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 7 237 2.772e-07 5.396e-05
4 CELL SUBSTRATE JUNCTION 7 398 8.688e-06 0.001015
5 MAST CELL GRANULE 3 21 8.22e-06 0.001015
6 MEMBRANE MICRODOMAIN 6 288 1.586e-05 0.001477
7 LAMELLIPODIUM 5 172 1.77e-05 0.001477
8 PLASMA MEMBRANE RAFT 4 86 2.104e-05 0.001536
9 ANCHORING JUNCTION 7 489 3.274e-05 0.002124
10 CYTOSKELETON 13 1967 3.958e-05 0.002312
11 CELL LEADING EDGE 6 350 4.735e-05 0.002514
12 EXTRINSIC COMPONENT OF PLASMA MEMBRANE 4 136 0.0001262 0.006141
13 ACTIN CYTOSKELETON 6 444 0.0001749 0.007858

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04370_VEGF_signaling_pathway 38 76 1.358e-97 2.445e-95
2 hsa04664_Fc_epsilon_RI_signaling_pathway 23 79 2.257e-47 2.031e-45
3 hsa04662_B_cell_receptor_signaling_pathway 22 75 2.989e-45 1.793e-43
4 hsa04650_Natural_killer_cell_mediated_cytotoxicity 22 136 7.069e-39 3.181e-37
5 hsa04014_Ras_signaling_pathway 23 236 1.996e-35 7.187e-34
6 hsa04660_T_cell_receptor_signaling_pathway 18 108 1.056e-31 3.169e-30
7 hsa04012_ErbB_signaling_pathway 17 87 3.629e-31 9.331e-30
8 hsa04666_Fc_gamma_R.mediated_phagocytosis 17 95 1.866e-30 4.199e-29
9 hsa04510_Focal_adhesion 19 200 1.251e-28 2.503e-27
10 hsa04010_MAPK_signaling_pathway 20 268 4.609e-28 8.297e-27
11 hsa04062_Chemokine_signaling_pathway 17 189 4.446e-25 7.274e-24
12 hsa04722_Neurotrophin_signaling_pathway 15 127 6.415e-24 9.623e-23
13 hsa04670_Leukocyte_transendothelial_migration 14 117 2.117e-22 2.931e-21
14 hsa04151_PI3K_AKT_signaling_pathway 18 351 3.941e-22 5.067e-21
15 hsa04380_Osteoclast_differentiation 14 128 7.907e-22 9.489e-21
16 hsa04960_Aldosterone.regulated_sodium_reabsorption 11 42 9.688e-22 1.09e-20
17 hsa04912_GnRH_signaling_pathway 13 101 3.044e-21 3.152e-20
18 hsa04730_Long.term_depression 12 70 3.152e-21 3.152e-20
19 hsa04810_Regulation_of_actin_cytoskeleton 15 214 2.093e-20 1.983e-19
20 hsa04150_mTOR_signaling_pathway 10 52 2.518e-18 2.266e-17
21 hsa04914_Progesterone.mediated_oocyte_maturation 11 87 5.994e-18 5.137e-17
22 hsa04360_Axon_guidance 12 130 7.942e-18 6.498e-17
23 hsa04910_Insulin_signaling_pathway 12 138 1.662e-17 1.3e-16
24 hsa04620_Toll.like_receptor_signaling_pathway 11 102 3.742e-17 2.807e-16
25 hsa04973_Carbohydrate_digestion_and_absorption 9 44 7.838e-17 5.644e-16
26 hsa04070_Phosphatidylinositol_signaling_system 10 78 1.937e-16 1.341e-15
27 hsa04210_Apoptosis 10 89 7.719e-16 5.146e-15
28 hsa04270_Vascular_smooth_muscle_contraction 10 116 1.196e-14 7.69e-14
29 hsa04310_Wnt_signaling_pathway 10 151 1.756e-13 1.09e-12
30 hsa04972_Pancreatic_secretion 9 101 2.143e-13 1.286e-12
31 hsa04720_Long.term_potentiation 8 70 6.703e-13 3.892e-12
32 hsa00592_alpha.Linolenic_acid_metabolism 6 20 1.182e-12 6.647e-12
33 hsa00590_Arachidonic_acid_metabolism 7 59 1.581e-11 8.625e-11
34 hsa00591_Linoleic_acid_metabolism 6 30 1.786e-11 9.454e-11
35 hsa00565_Ether_lipid_metabolism 6 36 5.81e-11 2.988e-10
36 hsa04975_Fat_digestion_and_absorption 6 46 2.756e-10 1.378e-09
37 hsa04540_Gap_junction 7 90 3.32e-10 1.615e-09
38 hsa04630_Jak.STAT_signaling_pathway 8 155 4.357e-10 2.064e-09
39 hsa00564_Glycerophospholipid_metabolism 6 80 8.437e-09 3.894e-08
40 hsa04916_Melanogenesis 6 101 3.457e-08 1.556e-07
41 hsa00562_Inositol_phosphate_metabolism 5 57 7.341e-08 3.223e-07
42 hsa04530_Tight_junction 6 133 1.79e-07 7.671e-07
43 hsa04020_Calcium_signaling_pathway 6 177 9.632e-07 4.032e-06
44 hsa04520_Adherens_junction 4 73 1.097e-05 4.49e-05
45 hsa04320_Dorso.ventral_axis_formation 3 25 1.414e-05 5.656e-05
46 hsa04114_Oocyte_meiosis 4 114 6.364e-05 0.000249
47 hsa04971_Gastric_acid_secretion 2 74 0.008711 0.03336
48 hsa04970_Salivary_secretion 2 89 0.01241 0.04652
49 hsa04144_Endocytosis 2 203 0.05678 0.2086

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

MAGI2-AS3

hsa-miR-130a-5p;hsa-miR-149-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-19b-1-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-429;hsa-miR-590-3p 10 KDR Sponge network -4.563 0 -3.788 0 0.657
2 RP11-389C8.2 hsa-miR-130a-5p;hsa-miR-149-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-19b-1-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-3065-3p;hsa-miR-429 10 KDR Sponge network -3.089 2.0E-5 -3.788 0 0.633
3 DNM3OS hsa-miR-149-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-19b-1-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-3065-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p 11 KDR Sponge network -3.933 0.00059 -3.788 0 0.586
4 MIR143HG hsa-miR-130a-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-19b-1-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-3065-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p 11 KDR Sponge network -6.51 0 -3.788 0 0.565
5

HAND2-AS1

hsa-miR-130a-5p;hsa-miR-149-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-19b-1-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-429;hsa-miR-590-3p 10 KDR Sponge network -7.871 0 -3.788 0 0.447
6

ADAMTS9-AS1

hsa-miR-130a-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-19b-1-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p 10 KDR Sponge network -8.573 0.00012 -3.788 0 0.425
7

MAGI2-AS3

hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-19b-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-24-3p;hsa-miR-26b-3p;hsa-miR-30b-5p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-3607-3p;hsa-miR-590-3p 12 NFATC2 Sponge network -4.563 0 -0.286 0.824 0.384
8

MAGI2-AS3

hsa-miR-130a-5p;hsa-miR-141-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-24-3p;hsa-miR-30d-3p;hsa-miR-335-3p;hsa-miR-429;hsa-miR-589-3p;hsa-miR-9-3p 10 PRKCB Sponge network -4.563 0 -1.378 0.12578 0.313
9

HAND2-AS1

hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-19b-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-2355-5p;hsa-miR-24-3p;hsa-miR-26b-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-3607-3p;hsa-miR-590-3p 12 NFATC2 Sponge network -7.871 0 -0.286 0.824 0.297

Quest ID: 30d3ef9e7e9b309ef0065c09ff1341c6