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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-28-5p APC2 -0.43 0 1.72 0 mirMAP -0.3 0.00527 NA
2 hsa-miR-15b-5p AXIN2 0.23 0.08248 0.11 0.75298 miRTarBase; MirTarget; miRNATAP -0.45 0.00081 NA
3 hsa-miR-16-2-3p AXIN2 -0.03 0.80516 0.11 0.75298 mirMAP -0.64 0 NA
4 hsa-miR-16-5p AXIN2 -0.4 0.0001 0.11 0.75298 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.49 0.00421 NA
5 hsa-miR-195-3p AXIN2 -1.09 0 0.11 0.75298 mirMAP -0.31 0.00083 NA
6 hsa-miR-26b-3p AXIN2 -1.26 0 0.11 0.75298 MirTarget -0.59 3.0E-5 NA
7 hsa-miR-326 AXIN2 -1.88 0 0.11 0.75298 miRanda -0.36 2.0E-5 NA
8 hsa-miR-338-5p AXIN2 -0.22 0.25239 0.11 0.75298 miRNATAP -0.34 0.00017 NA
9 hsa-miR-616-3p AXIN2 -0.7 2.0E-5 0.11 0.75298 MirTarget -0.42 8.0E-5 NA
10 hsa-miR-30e-3p CACYBP -1.21 0 0.95 0 MirTarget -0.35 0 NA
11 hsa-miR-15b-3p CAMK2A 0.24 0.09977 -0.33 0.35691 mirMAP -0.44 0.00022 NA
12 hsa-miR-21-3p CAMK2A -0.48 0.003 -0.33 0.35691 MirTarget -0.43 5.0E-5 NA
13 hsa-miR-7-1-3p CAMK2A -0.57 2.0E-5 -0.33 0.35691 MirTarget -0.36 0.00584 NA
14 hsa-miR-10b-3p CAMK2B 2.77 0 -3.79 0 mirMAP -0.45 0 NA
15 hsa-miR-10b-5p CAMK2B 2.87 0 -3.79 0 miRNATAP -0.42 0 NA
16 hsa-miR-140-3p CAMK2B 0.55 0 -3.79 0 mirMAP -1.81 0 NA
17 hsa-miR-186-5p CAMK2B -0.06 0.53529 -3.79 0 miRNAWalker2 validate; miRNATAP -0.97 5.0E-5 NA
18 hsa-miR-18a-5p CAMK2B 0.92 2.0E-5 -3.79 0 mirMAP -0.42 6.0E-5 NA
19 hsa-miR-34a-5p CAMK2B 1.04 0 -3.79 0 mirMAP -0.52 0.00135 NA
20 hsa-miR-589-3p CAMK2B 1.17 0 -3.79 0 MirTarget -0.78 0 NA
21 hsa-miR-106b-5p CCND1 0.65 0 -0.9 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.43 0 NA
22 hsa-miR-15b-5p CCND1 0.23 0.08248 -0.9 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.54 0 NA
23 hsa-miR-16-5p CCND1 -0.4 0.0001 -0.9 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.31 0.00178 23991964; 22922827; 18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL
24 hsa-miR-17-5p CCND1 0.7 2.0E-5 -0.9 1.0E-5 miRNAWalker2 validate; MirTarget; TargetScan; miRNATAP -0.34 0 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene
25 hsa-miR-186-5p CCND1 -0.06 0.53529 -0.9 1.0E-5 mirMAP -0.32 0.00286 NA
26 hsa-miR-19b-1-5p CCND1 -0.28 0.07831 -0.9 1.0E-5 miRNAWalker2 validate; miRTarBase -0.31 0 NA
27 hsa-miR-19b-3p CCND1 0.6 0.00017 -0.9 1.0E-5 miRNATAP -0.34 0 NA
28 hsa-miR-20a-5p CCND1 0.85 0 -0.9 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.33 0 NA
29 hsa-miR-340-5p CCND1 -0 0.9685 -0.9 1.0E-5 mirMAP -0.32 0.00013 NA
30 hsa-miR-425-5p CCND1 0.59 2.0E-5 -0.9 1.0E-5 miRNAWalker2 validate -0.39 0 NA
31 hsa-miR-92a-3p CCND1 0.21 0.13429 -0.9 1.0E-5 miRNAWalker2 validate -0.41 0 NA
32 hsa-miR-93-5p CCND1 1.4 0 -0.9 1.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.34 0 NA
33 hsa-miR-28-5p CCND2 -0.43 0 0.36 0.03656 miRanda -0.48 0 NA
34 hsa-miR-616-5p CCND2 0.15 0.40284 0.36 0.03656 mirMAP -0.32 0 NA
35 hsa-miR-22-3p CSNK2A1 -0.63 0 0.31 6.0E-5 miRNAWalker2 validate -0.31 0 NA
36 hsa-miR-616-5p CTBP2 0.15 0.40284 -0.39 0.02251 mirMAP -0.31 0 NA
37 hsa-miR-618 CTBP2 0.14 0.51715 -0.39 0.02251 MirTarget; PITA -0.33 0 NA
38 hsa-miR-21-5p DAAM1 1.51 0 -0.82 3.0E-5 miRNAWalker2 validate -0.58 0 NA
39 hsa-miR-92a-3p DAAM1 0.21 0.13429 -0.82 3.0E-5 miRNATAP -0.33 0 NA
40 hsa-miR-18a-5p DAAM2 0.92 2.0E-5 -0.83 6.0E-5 miRNAWalker2 validate -0.32 0 NA
41 hsa-miR-193a-3p DAAM2 -0.12 0.30939 -0.83 6.0E-5 miRanda -0.34 0.0001 NA
42 hsa-miR-339-5p DAAM2 0.28 0.03557 -0.83 6.0E-5 miRanda -0.41 0 NA
43 hsa-miR-29a-3p DKK1 -0.86 0 2.54 1.0E-5 miRNAWalker2 validate; miRTarBase -1.21 0 NA
44 hsa-miR-33a-3p DKK2 -0.68 1.0E-5 0.71 0.03131 mirMAP -0.4 0.00011 NA
45 hsa-miR-361-5p DKK2 0.23 0.00962 0.71 0.03131 miRanda -0.66 0.00028 NA
46 hsa-miR-374a-5p DKK2 0.02 0.86978 0.71 0.03131 mirMAP -0.77 0 NA
47 hsa-miR-374b-5p DKK2 -0.31 0.00301 0.71 0.03131 mirMAP -0.8 0 NA
48 hsa-miR-455-5p DKK2 -0.27 0.05813 0.71 0.03131 miRanda -0.45 6.0E-5 NA
49 hsa-miR-590-3p DKK2 -0.47 2.0E-5 0.71 0.03131 miRanda; mirMAP; miRNATAP -0.51 0.00043 NA
50 hsa-miR-590-5p DKK2 -0.1 0.31003 0.71 0.03131 miRanda -0.74 0 NA
51 hsa-miR-335-5p DKK4 -1.61 0 1.46 0.00691 miRNAWalker2 validate -0.64 0 NA
52 hsa-miR-192-5p FZD1 -0.5 0.00345 -0.99 0 miRNAWalker2 validate -0.46 0 NA
53 hsa-miR-107 FZD10 0.24 0.01708 1.19 0.00016 miRanda -0.69 1.0E-5 NA
54 hsa-miR-15a-5p FZD10 0.35 0.00077 1.19 0.00016 miRNATAP -0.44 0.00326 NA
55 hsa-miR-455-3p FZD10 -1.4 0 1.19 0.00016 PITA; miRNATAP -0.56 0 NA
56 hsa-miR-616-5p FZD2 0.15 0.40284 0.41 0.07557 MirTarget -0.34 0 NA
57 hsa-miR-107 FZD3 0.24 0.01708 -0.43 0.07605 MirTarget; miRanda -0.33 0.00541 NA
58 hsa-miR-30e-5p FZD3 -0.63 0 -0.43 0.07605 MirTarget -0.31 0.0078 NA
59 hsa-miR-361-5p FZD3 0.23 0.00962 -0.43 0.07605 miRanda; miRNATAP -0.46 0.0005 NA
60 hsa-miR-374a-5p FZD3 0.02 0.86978 -0.43 0.07605 mirMAP -0.52 2.0E-5 NA
61 hsa-miR-374b-5p FZD3 -0.31 0.00301 -0.43 0.07605 mirMAP -0.31 0.00624 NA
62 hsa-miR-106b-5p FZD4 0.65 0 -0.35 0.01097 miRNATAP -0.37 0 NA
63 hsa-miR-21-5p FZD4 1.51 0 -0.35 0.01097 mirMAP -0.32 0 NA
64 hsa-miR-324-3p FZD4 0.26 0.05061 -0.35 0.01097 miRNATAP -0.33 0 NA
65 hsa-miR-101-3p FZD6 -1.48 0 0.59 0.00374 miRNAWalker2 validate; MirTarget -0.31 1.0E-5 NA
66 hsa-miR-192-5p FZD7 -0.5 0.00345 -0.28 0.25656 miRNAWalker2 validate -0.59 0 NA
67 hsa-miR-192-5p FZD9 -0.5 0.00345 -0.24 0.50534 miRNATAP -0.31 0.0031 NA
68 hsa-miR-93-5p JUN 1.4 0 -1.6 0 miRNAWalker2 validate -0.35 0 NA
69 hsa-let-7a-3p LEF1 -0.57 0 2.66 0 miRNATAP -0.64 4.0E-5 NA
70 hsa-let-7b-3p LEF1 -1.22 0 2.66 0 miRNATAP -0.67 0 NA
71 hsa-miR-193b-3p LEF1 -0.17 0.27202 2.66 0 miRNAWalker2 validate -0.53 0 NA
72 hsa-miR-26a-5p LEF1 -0.96 0 2.66 0 miRNATAP -0.92 0 NA
73 hsa-miR-26b-5p LEF1 -1.11 0 2.66 0 miRNATAP -0.88 0 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression
74 hsa-miR-326 LEF1 -1.88 0 2.66 0 miRanda -0.39 0 NA
75 hsa-miR-33a-3p LEF1 -0.68 1.0E-5 2.66 0 miRNATAP -0.44 5.0E-5 NA
76 hsa-miR-455-5p LEF1 -0.27 0.05813 2.66 0 miRanda -0.35 0.00298 NA
77 hsa-miR-590-3p LEF1 -0.47 2.0E-5 2.66 0 PITA; miRanda; mirMAP -0.43 0.00459 NA
78 hsa-miR-7-1-3p LEF1 -0.57 2.0E-5 2.66 0 mirMAP -0.45 0.00035 NA
79 hsa-miR-221-3p MAPK10 1.12 0 -1.09 3.0E-5 miRNATAP -0.35 2.0E-5 NA
80 hsa-miR-590-5p MAPK10 -0.1 0.31003 -1.09 3.0E-5 PITA; miRanda; miRNATAP -0.37 0.00397 NA
81 hsa-miR-455-5p MMP7 -0.27 0.05813 -2.02 0.00038 miRanda -0.54 0.00528 NA
82 hsa-miR-423-5p MYC 0.7 0 -1.53 0 miRNAWalker2 validate -0.33 0.00485 NA
83 hsa-miR-455-5p NFATC1 -0.27 0.05813 -0.75 4.0E-5 miRanda -0.31 0 NA
84 hsa-miR-29a-5p NFATC2 -0.11 0.34962 -1.87 0 mirMAP; miRNATAP -0.58 6.0E-5 NA
85 hsa-miR-30d-5p NFATC2 0.72 0 -1.87 0 MirTarget; mirMAP -0.43 0.00143 NA
86 hsa-miR-24-3p NKD1 -0.26 0.0069 0.62 0.18603 miRNAWalker2 validate -0.72 0.00289 NA
87 hsa-miR-326 NKD1 -1.88 0 0.62 0.18603 miRanda -0.46 3.0E-5 NA
88 hsa-miR-330-5p NKD1 0.44 0.00533 0.62 0.18603 miRanda; miRNATAP -0.8 0 NA
89 hsa-miR-340-5p NKD1 -0 0.9685 0.62 0.18603 mirMAP -0.5 0.00902 NA
90 hsa-miR-501-5p NKD1 1.15 0 0.62 0.18603 mirMAP -0.34 0.00492 NA
91 hsa-let-7g-3p PLCB1 -1.14 0 1.21 0 miRNATAP -0.38 1.0E-5 NA
92 hsa-miR-125b-5p PLCB1 -1.36 0 1.21 0 miRNATAP -0.43 0 NA
93 hsa-miR-139-5p PLCB1 -2.11 0 1.21 0 miRanda -0.44 0 NA
94 hsa-miR-192-3p PLCB4 -0.64 0.00027 0.84 0.00057 miRNATAP -0.56 0 NA
95 hsa-miR-374a-5p PLCB4 0.02 0.86978 0.84 0.00057 mirMAP -0.4 0.00081 NA
96 hsa-miR-374b-5p PLCB4 -0.31 0.00301 0.84 0.00057 mirMAP -0.47 4.0E-5 NA
97 hsa-miR-590-3p PLCB4 -0.47 2.0E-5 0.84 0.00057 miRanda -0.41 0.00017 NA
98 hsa-miR-17-5p PRICKLE1 0.7 2.0E-5 -1.74 0 miRNAWalker2 validate -0.47 0 NA
99 hsa-miR-192-5p PRICKLE1 -0.5 0.00345 -1.74 0 miRNAWalker2 validate -0.65 0 NA
100 hsa-miR-361-5p PRICKLE1 0.23 0.00962 -1.74 0 miRanda -0.91 0 NA
101 hsa-miR-532-5p PRICKLE1 1.03 0 -1.74 0 miRNATAP -0.72 0 NA
102 hsa-miR-148a-3p PRICKLE2 -0.75 0 -1.36 0 MirTarget; miRNATAP -0.36 1.0E-5 NA
103 hsa-miR-148a-5p PRICKLE2 -0.77 0 -1.36 0 mirMAP -0.35 0 NA
104 hsa-miR-148b-3p PRICKLE2 0.27 0.00185 -1.36 0 MirTarget; miRNATAP -0.46 0.00102 NA
105 hsa-miR-589-5p PRICKLE2 1.19 0 -1.36 0 MirTarget; miRNATAP -0.54 0 NA
106 hsa-miR-194-5p PRKCB -0.29 0.09961 -1.62 0 miRNATAP -0.31 0 NA
107 hsa-miR-30d-5p PRKCB 0.72 0 -1.62 0 mirMAP -0.36 2.0E-5 NA
108 hsa-miR-361-5p PRKCB 0.23 0.00962 -1.62 0 MirTarget; miRanda; miRNATAP -0.42 0.00071 NA
109 hsa-miR-589-5p PRKCB 1.19 0 -1.62 0 mirMAP -0.55 0 NA
110 hsa-miR-664a-3p PRKCB 0.49 0.00073 -1.62 0 mirMAP -0.35 1.0E-5 NA
111 hsa-miR-140-3p PRKX 0.55 0 -0.24 0.24037 mirMAP -0.41 0.00049 NA
112 hsa-miR-148a-3p PRKX -0.75 0 -0.24 0.24037 MirTarget -0.59 0 NA
113 hsa-miR-23b-3p PRKX -0.53 0 -0.24 0.24037 mirMAP -0.34 0.00031 NA
114 hsa-miR-374a-3p PRKX -0.21 0.06235 -0.24 0.24037 mirMAP -0.33 0.0002 NA
115 hsa-miR-125a-5p RAC3 -0.91 0 0.67 0.00109 PITA -0.32 0 NA
116 hsa-miR-1301-3p SFRP1 1.12 0 -4.15 0 MirTarget -0.33 0.00114 NA
117 hsa-miR-16-1-3p SFRP1 0.39 0.00112 -4.15 0 MirTarget -0.72 0 NA
118 hsa-miR-192-3p SFRP1 -0.64 0.00027 -4.15 0 MirTarget -0.42 4.0E-5 NA
119 hsa-miR-501-5p SFRP1 1.15 0 -4.15 0 mirMAP -0.48 0 NA
120 hsa-miR-548b-3p SFRP1 -0.02 0.93082 -4.15 0 mirMAP -0.43 0 NA
121 hsa-miR-548j-5p SFRP1 0.25 0.17136 -4.15 0 MirTarget -0.45 1.0E-5 NA
122 hsa-miR-455-5p SFRP2 -0.27 0.05813 0.47 0.28903 miRanda -0.8 0 NA
123 hsa-miR-144-5p SFRP4 -1.55 0 2.13 0 MirTarget -0.35 0 NA
124 hsa-miR-26b-5p SFRP4 -1.11 0 2.13 0 miRNAWalker2 validate -0.77 0 NA
125 hsa-miR-3607-3p SFRP4 -2.16 0 2.13 0 MirTarget -0.34 1.0E-5 NA
126 hsa-miR-590-3p SOX17 -0.47 2.0E-5 0.08 0.62256 miRanda; miRNATAP -0.31 1.0E-5 NA
127 hsa-miR-590-5p SOX17 -0.1 0.31003 0.08 0.62256 miRanda -0.4 0 NA
128 hsa-miR-24-3p TCF7 -0.26 0.0069 0.32 0.14929 miRNATAP -0.56 0 NA
129 hsa-miR-30e-3p TCF7 -1.21 0 0.32 0.14929 mirMAP -0.35 6.0E-5 NA
130 hsa-miR-331-3p TCF7 -0.28 0.03738 0.32 0.14929 MirTarget; miRNATAP -0.48 0 NA
131 hsa-miR-107 VANGL2 0.24 0.01708 -0.7 0.02922 miRanda -0.71 0 NA
132 hsa-miR-140-3p VANGL2 0.55 0 -0.7 0.02922 PITA; miRNATAP -0.75 5.0E-5 NA
133 hsa-miR-362-3p VANGL2 0.81 0 -0.7 0.02922 PITA; miRanda; miRNATAP -0.33 0.00342 NA
134 hsa-miR-378a-5p VANGL2 -1.59 0 -0.7 0.02922 MirTarget -0.38 0 NA
135 hsa-miR-589-5p VANGL2 1.19 0 -0.7 0.02922 mirMAP -0.4 0.00101 NA
136 hsa-miR-28-5p WIF1 -0.43 0 0.56 0.11285 miRanda -0.5 0.00804 NA
137 hsa-miR-378a-3p WNT10A -1.19 0 -0.7 0.01484 MirTarget; miRNATAP -0.31 1.0E-5 NA
138 hsa-miR-664a-3p WNT10A 0.49 0.00073 -0.7 0.01484 mirMAP -0.33 0.00058 NA
139 hsa-miR-362-3p WNT2 0.81 0 -3.92 0 miRanda -0.6 7.0E-5 NA
140 hsa-miR-532-5p WNT2 1.03 0 -3.92 0 miRNATAP -1.17 0 NA
141 hsa-miR-548b-3p WNT2 -0.02 0.93082 -3.92 0 MirTarget -0.5 0 NA
142 hsa-miR-616-5p WNT2B 0.15 0.40284 0.92 9.0E-5 mirMAP -0.36 0 NA
143 hsa-miR-195-5p WNT3A -1.86 0 1.99 0 MirTarget; miRNATAP -0.34 0.0007 25174704; 26573286 MicroRNA 195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells; Luciferase reporter assay was used to determine whether Wnt3a was a target of miR-195; Furthermore Wnt3a was demonstrated to be directly targeted by miR-195; These findings suggest that miR-195 is key in regulating cell proliferation cell cycle and apoptosis through targeting Wnt3a;Eribulin upregulates miR 195 expression and downregulates Wnt3a expression in non basal like type of triple negative breast cancer cell MDA MB 231; The expression level of miR-195 targeting Wnt3a significantly decreased compared to the control in MDA-MB-231 whereas it significantly increased in HCC1143; These results showed that exposure to eribulin highly increased the expression of miR-195 while it decreased the expression of Wnt3a in non-basal-like type of TNBC
144 hsa-miR-27b-3p WNT3A -0.82 0 1.99 0 miRNATAP -0.55 0.00239 NA
145 hsa-miR-335-5p WNT3A -1.61 0 1.99 0 mirMAP -0.47 2.0E-5 NA
146 hsa-miR-107 WNT4 0.24 0.01708 -0.4 0.36379 PITA; miRNATAP -1.2 0 NA
147 hsa-miR-185-5p WNT5B 0.48 0 -1.14 0.00022 miRNAWalker2 validate -0.64 4.0E-5 NA
148 hsa-miR-34a-5p WNT7B 1.04 0 -2.5 0 mirMAP -0.87 0 NA
149 hsa-miR-505-3p WNT7B -1.2 0 -2.5 0 miRNATAP -0.34 0.00653 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 WNT SIGNALING PATHWAY 38 351 9.686e-57 4.507e-53
2 NON CANONICAL WNT SIGNALING PATHWAY 20 140 1.257e-30 2.925e-27
3 REGULATION OF WNT SIGNALING PATHWAY 24 310 2.375e-30 3.684e-27
4 CANONICAL WNT SIGNALING PATHWAY 18 95 6.763e-30 7.867e-27
5 REGULATION OF ORGAN MORPHOGENESIS 21 242 1.885e-27 1.754e-24
6 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 19 197 1.14e-25 8.84e-23
7 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 19 236 3.868e-24 2.571e-21
8 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 28 1021 2.968e-23 1.726e-20
9 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 32 1672 2.469e-22 1.149e-19
10 REGULATION OF EMBRYONIC DEVELOPMENT 15 114 2.255e-22 1.149e-19
11 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 16 162 9.052e-22 3.829e-19
12 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 13 110 8.116e-19 2.905e-16
13 EPITHELIUM DEVELOPMENT 24 945 7.835e-19 2.905e-16
14 ORGAN MORPHOGENESIS 22 841 1.983e-17 6.59e-15
15 REGULATION OF CELL DIFFERENTIATION 26 1492 1.593e-16 4.942e-14
16 TISSUE MORPHOGENESIS 18 533 4.279e-16 1.244e-13
17 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 23 1142 8.607e-16 2.356e-13
18 MORPHOGENESIS OF AN EPITHELIUM 16 400 1.843e-15 4.514e-13
19 TUBE MORPHOGENESIS 15 323 1.81e-15 4.514e-13
20 TISSUE DEVELOPMENT 25 1518 3.015e-15 7.014e-13
21 TUBE DEVELOPMENT 17 552 1.52e-14 3.368e-12
22 NEGATIVE REGULATION OF CELL COMMUNICATION 22 1192 2.778e-14 5.876e-12
23 POSITIVE REGULATION OF CELL DIFFERENTIATION 19 823 5.37e-14 1.086e-11
24 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 8 39 5.823e-14 1.129e-11
25 NEUROGENESIS 23 1402 6.933e-14 1.29e-11
26 NEURAL TUBE DEVELOPMENT 11 149 9.96e-14 1.782e-11
27 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 11 152 1.243e-13 2.142e-11
28 NEURON DIFFERENTIATION 19 874 1.572e-13 2.613e-11
29 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 16 554 2.84e-13 4.557e-11
30 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 22 1360 4.042e-13 6.27e-11
31 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 10 134 1.312e-12 1.97e-10
32 EMBRYONIC MORPHOGENESIS 15 539 3.091e-12 4.495e-10
33 SENSORY ORGAN DEVELOPMENT 14 493 1.428e-11 2.014e-09
34 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 119 1.696e-11 2.321e-09
35 EMBRYO DEVELOPMENT 17 894 3.444e-11 4.557e-09
36 TUBE FORMATION 9 129 3.526e-11 4.557e-09
37 POSITIVE REGULATION OF CELL COMMUNICATION 21 1532 3.961e-11 4.981e-09
38 REGULATION OF CATENIN IMPORT INTO NUCLEUS 6 27 5.763e-11 7.057e-09
39 MIDBRAIN DEVELOPMENT 8 90 6.653e-11 7.938e-09
40 NEURAL TUBE FORMATION 8 94 9.482e-11 1.103e-08
41 REGULATION OF CELL FATE SPECIFICATION 5 13 1.117e-10 1.268e-08
42 HEAD DEVELOPMENT 15 709 1.475e-10 1.634e-08
43 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 5 14 1.734e-10 1.877e-08
44 CELL FATE COMMITMENT 10 227 2.475e-10 2.618e-08
45 RESPONSE TO RETINOIC ACID 8 107 2.708e-10 2.8e-08
46 CELLULAR RESPONSE TO RETINOIC ACID 7 65 2.841e-10 2.874e-08
47 POSITIVE REGULATION OF RESPONSE TO STIMULUS 22 1929 3.96e-10 3.839e-08
48 POSITIVE REGULATION OF GENE EXPRESSION 21 1733 3.928e-10 3.839e-08
49 PATTERN SPECIFICATION PROCESS 12 418 4.514e-10 4.286e-08
50 POSITIVE REGULATION OF MOLECULAR FUNCTION 21 1791 7.195e-10 6.696e-08
51 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 15 801 7.97e-10 7.271e-08
52 CELL PROLIFERATION 14 672 8.364e-10 7.484e-08
53 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 16 957 9.867e-10 8.663e-08
54 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 11 365 1.596e-09 1.375e-07
55 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 19 1492 1.639e-09 1.387e-07
56 CENTRAL NERVOUS SYSTEM DEVELOPMENT 15 872 2.544e-09 2.114e-07
57 HEART MORPHOGENESIS 9 212 2.949e-09 2.407e-07
58 REGIONALIZATION 10 311 5.202e-09 4.173e-07
59 NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT 5 26 5.568e-09 4.318e-07
60 REGULATION OF CELL FATE COMMITMENT 5 26 5.568e-09 4.318e-07
61 CELL DEVELOPMENT 18 1426 5.893e-09 4.495e-07
62 CARDIOVASCULAR SYSTEM DEVELOPMENT 14 788 6.454e-09 4.767e-07
63 CIRCULATORY SYSTEM DEVELOPMENT 14 788 6.454e-09 4.767e-07
64 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 20 1848 8.679e-09 6.31e-07
65 STEM CELL PROLIFERATION 6 60 9.146e-09 6.547e-07
66 SOMITOGENESIS 6 62 1.119e-08 7.887e-07
67 CELLULAR RESPONSE TO ACID CHEMICAL 8 175 1.352e-08 9.392e-07
68 POSITIVE REGULATION OF EMBRYONIC DEVELOPMENT 5 33 1.982e-08 1.356e-06
69 NEURAL PRECURSOR CELL PROLIFERATION 6 70 2.349e-08 1.562e-06
70 BRAIN MORPHOGENESIS 5 34 2.32e-08 1.562e-06
71 REGULATION OF GASTRULATION 5 35 2.701e-08 1.77e-06
72 ANTERIOR POSTERIOR PATTERN SPECIFICATION 8 194 3.023e-08 1.927e-06
73 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 17 1395 3.012e-08 1.927e-06
74 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 8 197 3.405e-08 2.141e-06
75 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 19 1805 3.734e-08 2.317e-06
76 SOMITE DEVELOPMENT 6 78 4.532e-08 2.775e-06
77 REGULATION OF MESODERM DEVELOPMENT 4 15 5.013e-08 3.03e-06
78 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 11 513 5.352e-08 3.193e-06
79 EMBRYONIC ORGAN DEVELOPMENT 10 406 6.472e-08 3.812e-06
80 REPRODUCTIVE SYSTEM DEVELOPMENT 10 408 6.776e-08 3.941e-06
81 NEGATIVE REGULATION OF GENE EXPRESSION 17 1493 8.131e-08 4.671e-06
82 REGULATION OF CELL PROLIFERATION 17 1496 8.372e-08 4.75e-06
83 RESPONSE TO ACID CHEMICAL 9 319 1.008e-07 5.585e-06
84 SEGMENTATION 6 89 1.004e-07 5.585e-06
85 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 17 1517 1.025e-07 5.61e-06
86 POST ANAL TAIL MORPHOGENESIS 4 18 1.118e-07 6.046e-06
87 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 7 154 1.22e-07 6.523e-06
88 DIGESTIVE TRACT MORPHOGENESIS 5 48 1.39e-07 7.348e-06
89 REGULATION OF JNK CASCADE 7 159 1.517e-07 7.845e-06
90 SENSORY ORGAN MORPHOGENESIS 8 239 1.512e-07 7.845e-06
91 CELLULAR RESPONSE TO LIPID 10 457 1.943e-07 9.713e-06
92 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 14 1036 1.962e-07 9.713e-06
93 IMMUNE SYSTEM DEVELOPMENT 11 582 1.91e-07 9.713e-06
94 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 14 1036 1.962e-07 9.713e-06
95 HEART DEVELOPMENT 10 466 2.326e-07 1.139e-05
96 REGULATION OF MUSCLE TISSUE DEVELOPMENT 6 103 2.404e-07 1.141e-05
97 RESPONSE TO LIPID 13 888 2.37e-07 1.141e-05
98 REGULATION OF MUSCLE ORGAN DEVELOPMENT 6 103 2.404e-07 1.141e-05
99 REGULATION OF PHOSPHORUS METABOLIC PROCESS 17 1618 2.592e-07 1.218e-05
100 SOMATIC STEM CELL DIVISION 4 22 2.652e-07 1.234e-05
101 NEGATIVE REGULATION OF CELL DIFFERENTIATION 11 609 3.003e-07 1.383e-05
102 OUTFLOW TRACT MORPHOGENESIS 5 56 3.053e-07 1.393e-05
103 REGULATION OF OSTEOBLAST DIFFERENTIATION 6 112 3.953e-07 1.786e-05
104 REGULATION OF STEM CELL DIFFERENTIATION 6 113 4.166e-07 1.864e-05
105 MAMMARY GLAND DEVELOPMENT 6 117 5.118e-07 2.226e-05
106 MESENCHYME DEVELOPMENT 7 190 5.084e-07 2.226e-05
107 STEM CELL DIFFERENTIATION 7 190 5.084e-07 2.226e-05
108 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 12 799 5.749e-07 2.441e-05
109 REGULATION OF EPITHELIAL CELL PROLIFERATION 8 285 5.77e-07 2.441e-05
110 REGULATION OF PROTEIN MODIFICATION PROCESS 17 1710 5.688e-07 2.441e-05
111 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 14 1135 5.936e-07 2.488e-05
112 GLAND DEVELOPMENT 9 395 6.101e-07 2.535e-05
113 POSITIVE REGULATION OF CATALYTIC ACTIVITY 16 1518 6.272e-07 2.572e-05
114 AXIS ELONGATION 4 27 6.302e-07 2.572e-05
115 POSITIVE REGULATION OF CELL PROLIFERATION 12 814 7e-07 2.832e-05
116 DOPAMINERGIC NEURON DIFFERENTIATION 4 28 7.338e-07 2.944e-05
117 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 13 983 7.53e-07 2.995e-05
118 UROGENITAL SYSTEM DEVELOPMENT 8 299 8.282e-07 3.266e-05
119 STEM CELL DIVISION 4 29 8.497e-07 3.322e-05
120 SKIN EPIDERMIS DEVELOPMENT 5 71 1.011e-06 3.92e-05
121 REGULATION OF CELLULAR RESPONSE TO STRESS 11 691 1.045e-06 4.017e-05
122 RESPONSE TO OXYGEN CONTAINING COMPOUND 15 1381 1.07e-06 4.081e-05
123 REGULATION OF ORGAN FORMATION 4 32 1.279e-06 4.813e-05
124 MUSCLE STRUCTURE DEVELOPMENT 9 432 1.283e-06 4.813e-05
125 CELL ACTIVATION 10 568 1.413e-06 5.258e-05
126 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 7 228 1.725e-06 6.37e-05
127 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 7 229 1.776e-06 6.506e-05
128 REGULATION OF JUN KINASE ACTIVITY 5 81 1.952e-06 7.095e-05
129 CELLULAR COMPONENT MORPHOGENESIS 12 900 2.007e-06 7.24e-05
130 KIDNEY MORPHOGENESIS 5 82 2.075e-06 7.425e-05
131 HAIR CYCLE 5 83 2.203e-06 7.767e-05
132 MOLTING CYCLE 5 83 2.203e-06 7.767e-05
133 POSITIVE REGULATION OF GROWTH 7 238 2.294e-06 8.025e-05
134 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 11 750 2.317e-06 8.047e-05
135 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 10 602 2.379e-06 8.201e-05
136 VASCULATURE DEVELOPMENT 9 469 2.52e-06 8.622e-05
137 GASTRULATION 6 155 2.655e-06 9.019e-05
138 FOREBRAIN DEVELOPMENT 8 357 3.107e-06 0.0001048
139 REGULATION OF WNT SIGNALING PATHWAY PLANAR CELL POLARITY PATHWAY 3 12 3.381e-06 0.0001132
140 INNER EAR MORPHOGENESIS 5 92 3.668e-06 0.0001219
141 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 4 42 3.907e-06 0.0001282
142 EPITHELIAL CELL DIFFERENTIATION 9 495 3.913e-06 0.0001282
143 MORPHOGENESIS OF A BRANCHING STRUCTURE 6 167 4.087e-06 0.000133
144 NEGATIVE REGULATION OF STEM CELL DIFFERENTIATION 4 43 4.3e-06 0.000138
145 BETA CATENIN TCF COMPLEX ASSEMBLY 4 43 4.3e-06 0.000138
146 CELLULAR RESPONSE TO EXTERNAL STIMULUS 7 264 4.547e-06 0.0001449
147 SEX DIFFERENTIATION 7 266 4.779e-06 0.0001513
148 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 16 1784 5.255e-06 0.0001652
149 REGULATION OF MAPK CASCADE 10 660 5.382e-06 0.0001681
150 CONVERGENT EXTENSION 3 14 5.575e-06 0.0001729
151 REGULATION OF OSSIFICATION 6 178 5.901e-06 0.0001818
152 G PROTEIN COUPLED RECEPTOR SIGNALING PATHWAY 13 1193 6.433e-06 0.0001969
153 EMBRYONIC ORGAN MORPHOGENESIS 7 279 6.532e-06 0.0001987
154 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 4 48 6.717e-06 0.0002003
155 CARDIAC CHAMBER MORPHOGENESIS 5 104 6.703e-06 0.0002003
156 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 5 104 6.703e-06 0.0002003
157 REGULATION OF PROTEIN IMPORT 6 183 6.917e-06 0.000205
158 REGULATION OF FAT CELL DIFFERENTIATION 5 106 7.359e-06 0.0002167
159 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 6 188 8.071e-06 0.0002362
160 POSITIVE REGULATION OF FAT CELL DIFFERENTIATION 4 51 8.578e-06 0.0002494
161 EAR MORPHOGENESIS 5 112 9.63e-06 0.0002783
162 MAMMARY GLAND EPITHELIUM DEVELOPMENT 4 53 1.001e-05 0.0002876
163 ESTABLISHMENT OF TISSUE POLARITY 3 17 1.036e-05 0.0002957
164 REGULATION OF KIDNEY DEVELOPMENT 4 55 1.162e-05 0.0003296
165 EPITHELIAL TO MESENCHYMAL TRANSITION 4 56 1.249e-05 0.0003522
166 POSITIVE REGULATION OF HYDROLASE ACTIVITY 11 905 1.384e-05 0.0003879
167 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 5 121 1.403e-05 0.0003908
168 REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 3 19 1.471e-05 0.0004025
169 REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 3 19 1.471e-05 0.0004025
170 RESPONSE TO EXTRACELLULAR STIMULUS 8 441 1.455e-05 0.0004025
171 SKIN DEVELOPMENT 6 211 1.557e-05 0.0004236
172 REPRODUCTION 13 1297 1.582e-05 0.0004279
173 CHONDROCYTE DIFFERENTIATION 4 60 1.646e-05 0.0004426
174 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 6 216 1.777e-05 0.0004753
175 EYE DEVELOPMENT 7 326 1.793e-05 0.0004768
176 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 6 218 1.872e-05 0.000495
177 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 6 220 1.972e-05 0.0005183
178 REGULATION OF HYDROLASE ACTIVITY 13 1327 2.017e-05 0.0005272
179 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 5 131 2.06e-05 0.0005355
180 REGULATION OF CELLULAR COMPONENT MOVEMENT 10 771 2.082e-05 0.0005383
181 REGULATION OF CELL CYCLE 11 949 2.153e-05 0.0005535
182 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 7 337 2.219e-05 0.0005674
183 MESENCHYMAL CELL DIFFERENTIATION 5 134 2.298e-05 0.0005812
184 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 8 470 2.298e-05 0.0005812
185 BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY 3 22 2.325e-05 0.0005847
186 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 135 2.381e-05 0.0005958
187 LENS DEVELOPMENT IN CAMERA TYPE EYE 4 66 2.405e-05 0.0005984
188 RESPONSE TO GROWTH FACTOR 8 475 2.479e-05 0.0006135
189 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 4 67 2.553e-05 0.0006285
190 REGULATION OF CELL ADHESION 9 629 2.655e-05 0.0006502
191 REGULATION OF GROWTH 9 633 2.79e-05 0.0006797
192 MUSCLE ORGAN MORPHOGENESIS 4 70 3.037e-05 0.000736
193 CARDIAC CHAMBER DEVELOPMENT 5 144 3.248e-05 0.0007789
194 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 5 144 3.248e-05 0.0007789
195 CARTILAGE DEVELOPMENT 5 147 3.585e-05 0.0008554
196 BLOOD VESSEL MORPHOGENESIS 7 364 3.63e-05 0.0008617
197 DIGESTIVE SYSTEM DEVELOPMENT 5 148 3.703e-05 0.0008658
198 POSITIVE REGULATION OF CELL GROWTH 5 148 3.703e-05 0.0008658
199 MALE SEX DIFFERENTIATION 5 148 3.703e-05 0.0008658
200 REGULATION OF CELL DEVELOPMENT 10 836 4.152e-05 0.0009658
201 REGULATION OF MUSCLE CELL DIFFERENTIATION 5 152 4.207e-05 0.0009738
202 DEVELOPMENTAL INDUCTION 3 27 4.376e-05 0.001008
203 REGULATION OF BMP SIGNALING PATHWAY 4 77 4.424e-05 0.001014
204 VENTRICULAR SEPTUM MORPHOGENESIS 3 28 4.892e-05 0.00111
205 MORPHOGENESIS OF A POLARIZED EPITHELIUM 3 28 4.892e-05 0.00111
206 REGULATION OF FIBROBLAST PROLIFERATION 4 81 5.398e-05 0.001219
207 NEUROBLAST PROLIFERATION 3 29 5.447e-05 0.001224
208 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 5 162 5.699e-05 0.001275
209 REGULATION OF CELL DEATH 13 1472 5.966e-05 0.001328
210 RESPONSE TO X RAY 3 30 6.041e-05 0.001339
211 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 4 84 6.225e-05 0.001373
212 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 5 166 6.398e-05 0.001404
213 REGULATION OF CELL DIVISION 6 272 6.454e-05 0.00141
214 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 4 85 6.52e-05 0.001411
215 PALATE DEVELOPMENT 4 85 6.52e-05 0.001411
216 REGULATION OF STEM CELL PROLIFERATION 4 88 7.467e-05 0.001609
217 REGULATION OF CELL SUBSTRATE ADHESION 5 173 7.781e-05 0.001668
218 LEUKOCYTE ACTIVATION 7 414 8.169e-05 0.001744
219 IMMUNE SYSTEM PROCESS 15 1984 8.446e-05 0.001794
220 REGULATION OF DEVELOPMENTAL GROWTH 6 289 9.015e-05 0.001898
221 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 289 9.015e-05 0.001898
222 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 9 740 9.34e-05 0.001958
223 LEUKOCYTE DIFFERENTIATION 6 292 9.541e-05 0.001991
224 RESPONSE TO DRUG 7 431 0.000105 0.002164
225 NEGATIVE REGULATION OF MUSCLE ORGAN DEVELOPMENT 3 36 0.0001051 0.002164
226 NEGATIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 36 0.0001051 0.002164
227 REGULATION OF RECEPTOR INTERNALIZATION 3 37 0.0001142 0.00234
228 REGULATION OF TRANSPORT 14 1804 0.0001182 0.002412
229 CELL CELL SIGNALING 9 767 0.0001226 0.002492
230 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 11 1152 0.0001248 0.002526
231 REGULATION OF PROTEIN TARGETING 6 307 0.0001255 0.002528
232 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 4 102 0.0001325 0.002658
233 REGULATION OF KINASE ACTIVITY 9 776 0.0001339 0.002663
234 CONNECTIVE TISSUE DEVELOPMENT 5 194 0.0001334 0.002663
235 POSITIVE REGULATION OF CELL DEATH 8 605 0.0001353 0.002678
236 EAR DEVELOPMENT 5 195 0.0001366 0.002694
237 RESPIRATORY SYSTEM DEVELOPMENT 5 197 0.0001433 0.002814
238 POSITIVE REGULATION OF KIDNEY DEVELOPMENT 3 41 0.0001555 0.002954
239 SINGLE ORGANISM CELL ADHESION 7 459 0.000155 0.002954
240 NEGATIVE REGULATION OF TRANSPORT 7 458 0.0001529 0.002954
241 NEGATIVE REGULATION OF STRESS ACTIVATED MAPK CASCADE 3 41 0.0001555 0.002954
242 CARDIAC VENTRICLE DEVELOPMENT 4 106 0.0001538 0.002954
243 FAT CELL DIFFERENTIATION 4 106 0.0001538 0.002954
244 NEGATIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 3 41 0.0001555 0.002954
245 REGULATION OF MAP KINASE ACTIVITY 6 319 0.0001546 0.002954
246 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 4 108 0.0001653 0.003126
247 FORMATION OF PRIMARY GERM LAYER 4 110 0.0001774 0.003342
248 POSITIVE REGULATION OF MAPK CASCADE 7 470 0.0001792 0.003363
249 POSITIVE REGULATION OF CELL DEVELOPMENT 7 472 0.000184 0.003438
250 LYMPHOCYTE DIFFERENTIATION 5 209 0.0001888 0.003514
251 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 10 1004 0.0001896 0.003514
252 LABYRINTHINE LAYER DEVELOPMENT 3 44 0.0001922 0.003548
253 DEVELOPMENTAL GROWTH 6 333 0.0001951 0.003589
254 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 13 1656 0.0001968 0.003604
255 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 5 213 0.0002062 0.003762
256 POSITIVE REGULATION OF KINASE ACTIVITY 7 482 0.0002092 0.003802
257 NEPHRON DEVELOPMENT 4 115 0.0002104 0.00381
258 SPECIFICATION OF SYMMETRY 4 117 0.0002248 0.004033
259 LYMPHOCYTE ACTIVATION 6 342 0.0002253 0.004033
260 CELLULAR RESPONSE TO STARVATION 4 117 0.0002248 0.004033
261 REGULATION OF RESPONSE TO STRESS 12 1468 0.0002524 0.004499
262 CARDIAC SEPTUM MORPHOGENESIS 3 49 0.0002649 0.004705
263 T CELL DIFFERENTIATION 4 123 0.0002722 0.004817
264 REGULATION OF GTPASE ACTIVITY 8 673 0.0002794 0.004924
265 REGULATION OF SKELETAL MUSCLE TISSUE DEVELOPMENT 3 50 0.0002814 0.00494
266 KIDNEY EPITHELIUM DEVELOPMENT 4 125 0.0002895 0.005065
267 OSTEOBLAST DIFFERENTIATION 4 126 0.0002985 0.005201
268 HEPATICOBILIARY SYSTEM DEVELOPMENT 4 128 0.0003169 0.005502
269 NEGATIVE REGULATION OF CELL DEATH 9 872 0.0003196 0.005528
270 NEGATIVE REGULATION OF GROWTH 5 236 0.000331 0.005704
271 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 3 53 0.0003345 0.005722
272 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 3 53 0.0003345 0.005722
273 POSITIVE REGULATION OF CELL FATE COMMITMENT 2 11 0.0003455 0.005846
274 CARDIAC CELL FATE COMMITMENT 2 11 0.0003455 0.005846
275 POSITIVE REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 2 11 0.0003455 0.005846
276 VENTRICULAR SEPTUM DEVELOPMENT 3 54 0.0003535 0.00596
277 POSITIVE REGULATION OF CELL ADHESION 6 376 0.0003741 0.006285
278 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 56 0.0003937 0.006589
279 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 6 381 0.0004013 0.006693
280 POSITIVE REGULATION BY HOST OF VIRAL TRANSCRIPTION 2 12 0.000414 0.006806
281 HEART FORMATION 2 12 0.000414 0.006806
282 POSITIVE REGULATION OF CATENIN IMPORT INTO NUCLEUS 2 12 0.000414 0.006806
283 LENS FIBER CELL DEVELOPMENT 2 12 0.000414 0.006806
284 OSSIFICATION 5 251 0.0004388 0.007189
285 EPIDERMIS DEVELOPMENT 5 253 0.000455 0.007428
286 REGULATION OF CELL GROWTH 6 391 0.0004603 0.007463
287 VASCULOGENESIS 3 59 0.0004592 0.007463
288 FC EPSILON RECEPTOR SIGNALING PATHWAY 4 142 0.0004698 0.00759
289 INTRACELLULAR SIGNAL TRANSDUCTION 12 1572 0.0004726 0.007608
290 REGULATION OF CELL MORPHOGENESIS 7 552 0.0004745 0.007613
291 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 3 60 0.0004825 0.007715
292 NEURONAL STEM CELL DIVISION 2 13 0.0004884 0.00773
293 HEMATOPOIETIC STEM CELL PROLIFERATION 2 13 0.0004884 0.00773
294 NEUROBLAST DIVISION 2 13 0.0004884 0.00773
295 REGULATION OF CELL CYCLE PROCESS 7 558 0.0005061 0.007963
296 POSITIVE REGULATION OF STEM CELL PROLIFERATION 3 61 0.0005065 0.007963
297 RESPONSE TO IONIZING RADIATION 4 145 0.0005084 0.007965
298 EMBRYONIC HEART TUBE MORPHOGENESIS 3 62 0.0005313 0.008296
299 RESPONSE TO WOUNDING 7 563 0.0005337 0.008305
300 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 5 263 0.0005426 0.008389
301 NEGATIVE REGULATION OF LOCOMOTION 5 263 0.0005426 0.008389
302 POSITIVE REGULATION OF JUN KINASE ACTIVITY 3 63 0.0005569 0.00858
303 NEGATIVE REGULATION OF JUN KINASE ACTIVITY 2 14 0.0005689 0.008651
304 POSITIVE REGULATION OF MEIOTIC CELL CYCLE 2 14 0.0005689 0.008651
305 REGULATION OF MONOCYTE DIFFERENTIATION 2 14 0.0005689 0.008651
306 CELLULAR RESPONSE TO VITAMIN D 2 14 0.0005689 0.008651
307 REGULATION OF TRANSFERASE ACTIVITY 9 946 0.0005785 0.008768
308 GROWTH 6 410 0.0005909 0.008927
309 RESPONSE TO RADIATION 6 413 0.000614 0.009245
310 FOREBRAIN GENERATION OF NEURONS 3 66 0.0006383 0.009519
311 MESODERM MORPHOGENESIS 3 66 0.0006383 0.009519
312 RESPONSE TO STARVATION 4 154 0.0006376 0.009519
313 MESENCHYMAL TO EPITHELIAL TRANSITION 2 15 0.0006553 0.009742
NumGOOverlapSizeP ValueAdj. P Value
1 WNT PROTEIN BINDING 12 31 2.54e-24 2.36e-21
2 WNT ACTIVATED RECEPTOR ACTIVITY 11 22 6.435e-24 2.989e-21
3 FRIZZLED BINDING 10 36 1.099e-18 3.403e-16
4 G PROTEIN COUPLED RECEPTOR BINDING 10 259 8.936e-10 2.075e-07
5 SIGNAL TRANSDUCER ACTIVITY 19 1731 1.896e-08 3.523e-06
6 BETA CATENIN BINDING 6 84 7.089e-08 9.408e-06
7 RECEPTOR AGONIST ACTIVITY 4 16 6.672e-08 9.408e-06
8 PDZ DOMAIN BINDING 6 90 1.073e-07 1.108e-05
9 RECEPTOR REGULATOR ACTIVITY 5 45 9.972e-08 1.108e-05
10 RECEPTOR BINDING 16 1476 4.3e-07 3.994e-05
11 RECEPTOR ACTIVATOR ACTIVITY 4 32 1.279e-06 0.000108
12 PROTEIN DOMAIN SPECIFIC BINDING 10 624 3.276e-06 0.0002536
13 MOLECULAR FUNCTION REGULATOR 14 1353 4.739e-06 0.0003387
14 TRANSCRIPTION FACTOR BINDING 9 524 6.204e-06 0.0004117
15 G PROTEIN COUPLED RECEPTOR ACTIVITY 11 879 1.053e-05 0.0006521
16 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 4 90 8.151e-05 0.004454
17 ENZYME BINDING 14 1737 7.861e-05 0.004454
18 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 6 315 0.0001444 0.007452
19 SIGNALING RECEPTOR ACTIVITY 12 1393 0.0001546 0.00756
NumGOOverlapSizeP ValueAdj. P Value
1 ENDOCYTIC VESICLE MEMBRANE 8 152 4.466e-09 2.608e-06
2 EXTRACELLULAR MATRIX 10 426 1.013e-07 2.959e-05
3 ENDOCYTIC VESICLE 8 256 2.557e-07 3.733e-05
4 PROTEINACEOUS EXTRACELLULAR MATRIX 9 356 2.553e-07 3.733e-05
5 CELL SURFACE 12 757 3.235e-07 3.779e-05
6 VESICLE MEMBRANE 9 512 5.145e-06 0.0004651
7 BETA CATENIN DESTRUCTION COMPLEX 3 14 5.575e-06 0.0004651
8 CYTOPLASMIC VESICLE PART 9 601 1.855e-05 0.001354
9 EXTRACELLULAR SPACE 13 1376 2.957e-05 0.001919
10 TRANSCRIPTIONAL REPRESSOR COMPLEX 4 74 3.782e-05 0.002209
11 GOLGI LUMEN 4 94 9.656e-05 0.005126

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04310_Wnt_signaling_pathway 51 151 4.376e-113 7.745e-111
2 hsa04916_Melanogenesis 23 101 1.78e-40 1.576e-38
3 hsa04340_Hedgehog_signaling_pathway 8 56 1.301e-12 7.678e-11
4 hsa04912_GnRH_signaling_pathway 8 101 1.698e-10 7.516e-09
5 hsa04720_Long.term_potentiation 6 70 2.349e-08 8.317e-07
6 hsa04971_Gastric_acid_secretion 6 74 3.294e-08 9.717e-07
7 hsa04012_ErbB_signaling_pathway 6 87 8.756e-08 2.214e-06
8 hsa04662_B_cell_receptor_signaling_pathway 5 75 1.33e-06 2.943e-05
9 hsa04010_MAPK_signaling_pathway 7 268 5.019e-06 9.871e-05
10 hsa04020_Calcium_signaling_pathway 6 177 5.713e-06 0.0001011
11 hsa04510_Focal_adhesion 6 200 1.149e-05 0.0001848
12 hsa04520_Adherens_junction 4 73 3.585e-05 0.0005288
13 hsa04370_VEGF_signaling_pathway 4 76 4.202e-05 0.0005721
14 hsa04970_Salivary_secretion 4 89 7.804e-05 0.0009619
15 hsa04540_Gap_junction 4 90 8.151e-05 0.0009619
16 hsa04270_Vascular_smooth_muscle_contraction 4 116 0.0002176 0.002407
17 hsa04722_Neurotrophin_signaling_pathway 4 127 0.0003076 0.003116
18 hsa04380_Osteoclast_differentiation 4 128 0.0003169 0.003116
19 hsa04650_Natural_killer_cell_mediated_cytotoxicity 4 136 0.000399 0.003717
20 hsa04730_Long.term_depression 3 70 0.0007581 0.006709
21 hsa04070_Phosphatidylinositol_signaling_system 3 78 0.001039 0.00867
22 hsa04664_Fc_epsilon_RI_signaling_pathway 3 79 0.001078 0.00867
23 hsa04062_Chemokine_signaling_pathway 4 189 0.001365 0.0105
24 hsa04972_Pancreatic_secretion 3 101 0.002183 0.0161
25 hsa04660_T_cell_receptor_signaling_pathway 3 108 0.002642 0.0187
26 hsa04114_Oocyte_meiosis 3 114 0.003078 0.02096
27 hsa04110_Cell_cycle 3 128 0.004262 0.02794
28 hsa04360_Axon_guidance 3 130 0.004451 0.02814
29 hsa04630_Jak.STAT_signaling_pathway 3 155 0.007243 0.04421
30 hsa00562_Inositol_phosphate_metabolism 2 57 0.009304 0.05489
31 hsa04115_p53_signaling_pathway 2 69 0.01341 0.07658
32 hsa04914_Progesterone.mediated_oocyte_maturation 2 87 0.02078 0.1149
33 hsa04620_Toll.like_receptor_signaling_pathway 2 102 0.02792 0.1498
34 hsa04530_Tight_junction 2 133 0.04528 0.2357
35 hsa04910_Insulin_signaling_pathway 2 138 0.04838 0.2446
36 hsa04740_Olfactory_transduction 3 388 0.07631 0.3752
37 hsa04810_Regulation_of_actin_cytoskeleton 2 214 0.1034 0.4707

Quest ID: 3220d498c95cfd900c6f32c17cfeb346