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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-125a-5p ADAM10 0.45 0 -0.39 0.00177 miRanda -0.16 0.00349 NA
2 hsa-miR-335-3p ADAM10 0.32 3.0E-5 -0.39 0.00177 mirMAP -0.26 0.00011 NA
3 hsa-miR-484 ADAM10 -0.69 0 -0.39 0.00177 miRNAWalker2 validate -0.16 0.00158 NA
4 hsa-miR-548b-3p ADAM10 -0.8 0 -0.39 0.00177 PITA -0.12 0.00056 NA
5 hsa-miR-590-3p ADAM10 -0.33 0.00051 -0.39 0.00177 PITA; miRanda -0.15 0.00559 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 PROTEOLYSIS 31 1208 3.082e-13 1.434e-09
2 NOTCH SIGNALING PATHWAY 12 114 1.601e-12 3.724e-09
3 REGULATION OF NOTCH SIGNALING PATHWAY 10 67 3.492e-12 5.416e-09
4 POSITIVE REGULATION OF NOTCH SIGNALING PATHWAY 8 34 1.122e-11 1.044e-08
5 REGULATION OF CATABOLIC PROCESS 23 731 1.112e-11 1.044e-08
6 PROTEIN MATURATION 14 265 2.44e-10 1.893e-07
7 REGULATION OF PROTEOLYSIS 21 711 3.163e-10 2.103e-07
8 POSITIVE REGULATION OF RESPONSE TO STIMULUS 34 1929 5.458e-10 2.619e-07
9 POSITIVE REGULATION OF CELL COMMUNICATION 30 1532 6.579e-10 2.619e-07
10 POSITIVE REGULATION OF CATABOLIC PROCESS 16 395 5.85e-10 2.619e-07
11 REGULATION OF PROTEIN CATABOLIC PROCESS 16 393 5.434e-10 2.619e-07
12 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 24 983 6.755e-10 2.619e-07
13 POSITIVE REGULATION OF CELL DEATH 19 605 8.963e-10 3.208e-07
14 EPHRIN RECEPTOR SIGNALING PATHWAY 9 85 1.041e-09 3.461e-07
15 POSITIVE REGULATION OF PROTEOLYSIS 15 363 1.607e-09 4.984e-07
16 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 17 498 2.187e-09 6.359e-07
17 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 13 263 2.498e-09 6.837e-07
18 REGULATION OF BINDING 13 283 6.039e-09 1.561e-06
19 CELLULAR RESPONSE TO OXYGEN LEVELS 10 143 7.085e-09 1.735e-06
20 RESPONSE TO OXYGEN LEVELS 13 311 1.857e-08 4.321e-06
21 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 6 32 2.055e-08 4.552e-06
22 REGULATION OF CELL DEATH 27 1472 2.328e-08 4.924e-06
23 POSITIVE REGULATION OF MOLECULAR FUNCTION 30 1791 2.486e-08 5.029e-06
24 NEUROGENESIS 26 1402 3.618e-08 7.015e-06
25 RESPONSE TO ABIOTIC STIMULUS 22 1024 3.917e-08 7.278e-06
26 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 12 274 4.067e-08 7.278e-06
27 POSITIVE REGULATION OF ERBB SIGNALING PATHWAY 6 36 4.337e-08 7.474e-06
28 ERROR PRONE TRANSLESION SYNTHESIS 5 19 5.256e-08 8.734e-06
29 ERBB2 SIGNALING PATHWAY 6 39 7.167e-08 1.15e-05
30 REGULATION OF RESPONSE TO STRESS 26 1468 9.071e-08 1.407e-05
31 NEGATIVE REGULATION OF MOLECULAR FUNCTION 22 1079 9.813e-08 1.473e-05
32 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 10 192 1.17e-07 1.702e-05
33 CELL CYCLE CHECKPOINT 10 194 1.289e-07 1.818e-05
34 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 26 1517 1.732e-07 2.371e-05
35 GLYCOGEN BIOSYNTHETIC PROCESS 5 25 2.338e-07 3.022e-05
36 GLUCAN BIOSYNTHETIC PROCESS 5 25 2.338e-07 3.022e-05
37 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 17 689 2.478e-07 3.116e-05
38 REGULATION OF NECROTIC CELL DEATH 5 26 2.882e-07 3.406e-05
39 CATABOLIC PROCESS 28 1773 2.822e-07 3.406e-05
40 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 16 616 2.928e-07 3.406e-05
41 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 27 1672 3.136e-07 3.52e-05
42 CELLULAR RESPONSE TO STRESS 26 1565 3.177e-07 3.52e-05
43 CARBOHYDRATE BIOSYNTHETIC PROCESS 8 121 3.732e-07 4.038e-05
44 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 21 1087 4.893e-07 5.174e-05
45 POSITIVE REGULATION OF BINDING 8 127 5.408e-07 5.592e-05
46 CELLULAR GLUCAN METABOLIC PROCESS 6 58 8.163e-07 8.081e-05
47 GLUCAN METABOLIC PROCESS 6 58 8.163e-07 8.081e-05
48 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR 5 32 8.593e-07 8.33e-05
49 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 8 139 1.075e-06 1e-04
50 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 7 96 1.064e-06 1e-04
51 PROTEIN LOCALIZATION TO MEMBRANE 12 376 1.212e-06 0.0001106
52 NOTCH RECEPTOR PROCESSING 4 16 1.553e-06 0.000139
53 NEGATIVE REGULATION OF GENE EXPRESSION 24 1493 1.792e-06 0.0001539
54 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 24 1492 1.771e-06 0.0001539
55 VIRION ASSEMBLY 5 37 1.819e-06 0.0001539
56 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 6 67 1.933e-06 0.0001606
57 MACROMOLECULAR COMPLEX ASSEMBLY 23 1398 2.082e-06 0.0001699
58 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 19 1004 2.518e-06 0.000202
59 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 9 211 2.722e-06 0.0002147
60 CELL DEVELOPMENT 23 1426 2.909e-06 0.0002256
61 ENERGY RESERVE METABOLIC PROCESS 6 72 2.959e-06 0.0002257
62 TRANSLESION SYNTHESIS 5 41 3.073e-06 0.0002306
63 POLYSACCHARIDE BIOSYNTHETIC PROCESS 5 42 3.473e-06 0.0002407
64 ENERGY DERIVATION BY OXIDATION OF ORGANIC COMPOUNDS 9 217 3.424e-06 0.0002407
65 ERROR FREE TRANSLESION SYNTHESIS 4 19 3.266e-06 0.0002407
66 DNA SYNTHESIS INVOLVED IN DNA REPAIR 6 74 3.477e-06 0.0002407
67 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 8 162 3.393e-06 0.0002407
68 REGULATION OF CELL DEVELOPMENT 17 836 3.518e-06 0.0002407
69 DNA METABOLIC PROCESS 16 758 4.388e-06 0.0002959
70 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 22 1360 4.755e-06 0.0003161
71 CELL CELL SIGNALING 16 767 5.095e-06 0.0003251
72 ERBB SIGNALING PATHWAY 6 79 5.101e-06 0.0003251
73 DNA BIOSYNTHETIC PROCESS 7 121 5.03e-06 0.0003251
74 GENERATION OF PRECURSOR METABOLITES AND ENERGY 10 292 5.307e-06 0.0003337
75 POLYSACCHARIDE METABOLIC PROCESS 6 80 5.49e-06 0.0003406
76 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 15 684 5.697e-06 0.0003488
77 NEGATIVE REGULATION OF CELL DEATH 17 872 6.153e-06 0.0003624
78 MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 4 22 6.085e-06 0.0003624
79 NUCLEOTIDE EXCISION REPAIR DNA DUPLEX UNWINDING 4 22 6.085e-06 0.0003624
80 REGULATION OF ERBB SIGNALING PATHWAY 6 83 6.803e-06 0.0003908
81 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 236 6.771e-06 0.0003908
82 NEGATIVE REGULATION OF CELL DIFFERENTIATION 14 609 7.046e-06 0.0003998
83 NEGATIVE REGULATION OF CELL DEVELOPMENT 10 303 7.343e-06 0.0004068
84 NUCLEOTIDE EXCISION REPAIR DNA DAMAGE RECOGNITION 4 23 7.335e-06 0.0004068
85 RESPONSE TO TOXIC SUBSTANCE 9 241 8.018e-06 0.0004389
86 IMMUNE SYSTEM PROCESS 27 1984 8.372e-06 0.0004529
87 EMBRYO DEVELOPMENT 17 894 8.533e-06 0.0004564
88 NUCLEOTIDE EXCISION REPAIR DNA GAP FILLING 4 24 8.765e-06 0.0004634
89 NEGATIVE REGULATION OF TRANSPORT 12 458 9.151e-06 0.0004713
90 MEMBRANE ORGANIZATION 17 899 9.177e-06 0.0004713
91 CELLULAR CARBOHYDRATE BIOSYNTHETIC PROCESS 5 51 9.218e-06 0.0004713
92 REGULATION OF CELL ADHESION 14 629 1.015e-05 0.0005134
93 REGULATION OF NEURON DEATH 9 252 1.147e-05 0.0005737
94 RESPONSE TO ORGANIC CYCLIC COMPOUND 17 917 1.188e-05 0.0005844
95 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 25 1784 1.193e-05 0.0005844
96 POSTREPLICATION REPAIR 5 54 1.225e-05 0.0005936
97 MITOTIC CELL CYCLE CHECKPOINT 7 139 1.252e-05 0.0005994
98 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 18 1021 1.262e-05 0.0005994
99 RESPONSE TO ENDOGENOUS STIMULUS 22 1450 1.313e-05 0.0006112
100 REGULATION OF DNA BINDING 6 93 1.313e-05 0.0006112
101 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 16 829 1.346e-05 0.0006201
102 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 25 1805 1.459e-05 0.0006527
103 PROTEIN LOCALIZATION 25 1805 1.459e-05 0.0006527
104 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 15 740 1.451e-05 0.0006527
105 POSITIVE REGULATION OF KINASE ACTIVITY 12 482 1.523e-05 0.000675
106 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 4 28 1.66e-05 0.0007219
107 NEGATIVE REGULATION OF NOTCH SIGNALING PATHWAY 4 28 1.66e-05 0.0007219
108 DNA INTEGRITY CHECKPOINT 7 146 1.724e-05 0.0007427
109 CARBOHYDRATE METABOLIC PROCESS 14 662 1.797e-05 0.0007534
110 INTERSPECIES INTERACTION BETWEEN ORGANISMS 14 662 1.797e-05 0.0007534
111 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 14 662 1.797e-05 0.0007534
112 NUCLEOTIDE EXCISION REPAIR PREINCISION COMPLEX ASSEMBLY 4 29 1.918e-05 0.0007967
113 PROTEIN CATABOLIC PROCESS 13 579 1.966e-05 0.0008097
114 PROTEASOMAL PROTEIN CATABOLIC PROCESS 9 271 2.042e-05 0.0008335
115 CELL PROLIFERATION 14 672 2.122e-05 0.0008585
116 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 4 30 2.203e-05 0.0008837
117 SOMITOGENESIS 5 62 2.419e-05 0.0009539
118 SYNAPTIC SIGNALING 11 424 2.415e-05 0.0009539
119 CEREBRAL CORTEX DEVELOPMENT 6 105 2.628e-05 0.001027
120 POSITIVE REGULATION OF CATALYTIC ACTIVITY 22 1518 2.667e-05 0.001034
121 MYD88 DEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 4 32 2.866e-05 0.001091
122 REGULATION OF CELLULAR RESPONSE TO STRESS 14 691 2.883e-05 0.001091
123 NEGATIVE REGULATION OF CELL COMMUNICATION 19 1192 2.871e-05 0.001091
124 REGULATION OF CELL CYCLE ARREST 6 108 3.083e-05 0.001157
125 ESTABLISHMENT OF PROTEIN LOCALIZATION 21 1423 3.223e-05 0.001199
126 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 4 33 3.248e-05 0.001199
127 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 7 162 3.369e-05 0.001234
128 CELLULAR CATABOLIC PROCESS 20 1322 3.615e-05 0.001263
129 CELL DEATH 17 1001 3.632e-05 0.001263
130 AMYLOID PRECURSOR PROTEIN METABOLIC PROCESS 3 12 3.529e-05 0.001263
131 OXIDATION REDUCTION PROCESS 16 898 3.564e-05 0.001263
132 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 15 801 3.636e-05 0.001263
133 REGULATION OF TYPE I INTERFERON PRODUCTION 6 111 3.599e-05 0.001263
134 SINGLE ORGANISM CELLULAR LOCALIZATION 16 898 3.564e-05 0.001263
135 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 13 616 3.74e-05 0.001289
136 NUCLEOTIDE EXCISION REPAIR 6 113 3.98e-05 0.001362
137 NEURON APOPTOTIC PROCESS 4 35 4.12e-05 0.001389
138 MEMBRANE PROTEIN PROTEOLYSIS 4 35 4.12e-05 0.001389
139 REGULATION OF PROTEIN BINDING 7 168 4.249e-05 0.001412
140 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 7 168 4.249e-05 0.001412
141 INTRACELLULAR SIGNAL TRANSDUCTION 22 1572 4.532e-05 0.001496
142 MATURE B CELL DIFFERENTIATION INVOLVED IN IMMUNE RESPONSE 3 13 4.57e-05 0.001497
143 DNA DAMAGE RESPONSE DETECTION OF DNA DAMAGE 4 36 4.616e-05 0.001502
144 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN CELL CELL SIGNALING 5 71 4.678e-05 0.001512
145 NEGATIVE REGULATION OF NEURON DEATH 7 171 4.755e-05 0.001526
146 REGULATION OF GROWTH 13 633 4.943e-05 0.001575
147 NEURON PROJECTION DEVELOPMENT 12 545 5.054e-05 0.0016
148 MACROMOLECULE CATABOLIC PROCESS 16 926 5.143e-05 0.001617
149 POSITIVE REGULATION OF PROTEIN BINDING 5 73 5.35e-05 0.001627
150 TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR 5 73 5.35e-05 0.001627
151 CELL MATRIX ADHESION 6 119 5.321e-05 0.001627
152 G1 DNA DAMAGE CHECKPOINT 5 73 5.35e-05 0.001627
153 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 6 119 5.321e-05 0.001627
154 REGULATION OF PROTEIN MODIFICATION PROCESS 23 1710 5.459e-05 0.001649
155 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 17 1036 5.575e-05 0.001663
156 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 17 1036 5.575e-05 0.001663
157 REGULATION OF WNT SIGNALING PATHWAY 9 310 5.824e-05 0.001715
158 CELLULAR RESPONSE TO ARSENIC CONTAINING SUBSTANCE 3 14 5.792e-05 0.001715
159 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 12 554 5.914e-05 0.00172
160 REGULATION OF MITOTIC CELL CYCLE 11 468 5.914e-05 0.00172
161 REGULATION OF ORGAN MORPHOGENESIS 8 242 6.188e-05 0.001788
162 NEGATIVE REGULATION OF ENDOCYTOSIS 4 39 6.363e-05 0.001816
163 NUCLEOTIDE EXCISION REPAIR DNA INCISION 4 39 6.363e-05 0.001816
164 REGULATION OF CELL DIFFERENTIATION 21 1492 6.415e-05 0.00182
165 REGULATION OF TRANSFERASE ACTIVITY 16 946 6.622e-05 0.001867
166 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 7 181 6.811e-05 0.001909
167 NEGATIVE REGULATION OF TYPE I INTERFERON PRODUCTION 4 40 7.04e-05 0.001961
168 REGULATION OF MAP KINASE ACTIVITY 9 319 7.254e-05 0.002009
169 SOMITE DEVELOPMENT 5 78 7.355e-05 0.002025
170 DNA REPAIR 11 480 7.415e-05 0.002029
171 CELL ACTIVATION 12 568 7.502e-05 0.002041
172 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 6 127 7.648e-05 0.002045
173 REGULATION OF CELL CYCLE PHASE TRANSITION 9 321 7.609e-05 0.002045
174 NEGATIVE REGULATION OF ION TRANSPORT 6 127 7.648e-05 0.002045
175 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 5 79 7.818e-05 0.002079
176 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 6 128 7.988e-05 0.002112
177 DNA GEOMETRIC CHANGE 5 81 8.81e-05 0.002316
178 MESENCHYME DEVELOPMENT 7 190 9.236e-05 0.002414
179 JNK CASCADE 5 82 9.341e-05 0.002422
180 REGULATION OF CELLULAR COMPONENT MOVEMENT 14 771 9.37e-05 0.002422
181 NEURON DIFFERENTIATION 15 874 9.72e-05 0.002499
182 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 22 1656 9.812e-05 0.002507
183 REGULATION OF NEURON APOPTOTIC PROCESS 7 192 9.86e-05 0.002507
184 REGULATION OF KINASE ACTIVITY 14 776 0.0001003 0.002537
185 NEGATIVE REGULATION OF ERBB SIGNALING PATHWAY 4 44 0.0001028 0.002572
186 INTERSTRAND CROSS LINK REPAIR 4 44 0.0001028 0.002572
187 MEMBRANE PROTEIN INTRACELLULAR DOMAIN PROTEOLYSIS 3 17 0.0001069 0.002646
188 MATURE B CELL DIFFERENTIATION 3 17 0.0001069 0.002646
189 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 8 262 0.0001076 0.002648
190 POSITIVE REGULATION OF CELL CYCLE ARREST 5 85 0.0001108 0.002714
191 ESTABLISHMENT OF PROTEIN LOCALIZATION TO MEMBRANE 8 264 0.0001134 0.002762
192 ORGANONITROGEN COMPOUND METABOLIC PROCESS 23 1796 0.0001152 0.00279
193 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 7 197 0.0001157 0.00279
194 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 7 199 0.0001232 0.002955
195 REGULATION OF CELL MATURATION 3 18 0.0001278 0.003033
196 LABYRINTHINE LAYER BLOOD VESSEL DEVELOPMENT 3 18 0.0001278 0.003033
197 NEURON DEATH 4 47 0.0001334 0.00315
198 B CELL DIFFERENTIATION 5 89 0.0001378 0.003222
199 SEGMENTATION 5 89 0.0001378 0.003222
200 PLASMA MEMBRANE ORGANIZATION 7 203 0.0001394 0.003227
201 NEGATIVE REGULATION OF CATABOLIC PROCESS 7 203 0.0001394 0.003227
202 RESPONSE TO EXTERNAL STIMULUS 23 1821 0.0001417 0.003248
203 FC EPSILON RECEPTOR SIGNALING PATHWAY 6 142 0.0001415 0.003248
204 POSITIVE REGULATION OF WOUND HEALING 4 48 0.0001449 0.003304
205 MUSCLE STRUCTURE DEVELOPMENT 10 432 0.0001472 0.003341
206 CELLULAR MACROMOLECULE LOCALIZATION 18 1234 0.0001481 0.003346
207 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 9 351 0.0001496 0.003363
208 CELLULAR CARBOHYDRATE METABOLIC PROCESS 6 144 0.0001528 0.003418
209 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 6 146 0.0001647 0.003667
210 LYMPHOCYTE DIFFERENTIATION 7 209 0.0001668 0.003697
211 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 8 280 0.0001698 0.003714
212 MULTICELLULAR ORGANISM METABOLIC PROCESS 5 93 0.0001695 0.003714
213 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 4 50 0.00017 0.003714
214 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 6 147 0.000171 0.003717
215 REGULATION OF PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 6 148 0.0001774 0.003839
216 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 13 720 0.0001792 0.003859
217 BIOLOGICAL ADHESION 16 1032 0.0001813 0.003888
218 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 15 926 0.0001832 0.003911
219 POSITIVE REGULATION OF GENE EXPRESSION 22 1733 0.0001892 0.004019
220 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 17 1152 0.0002015 0.004223
221 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 9 365 0.0002003 0.004223
222 REGULATION OF PHOSPHORUS METABOLIC PROCESS 21 1618 0.0002006 0.004223
223 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 6 152 0.000205 0.004278
224 PALLIUM DEVELOPMENT 6 153 0.0002125 0.004413
225 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 5 98 0.0002167 0.004481
226 LEUKOCYTE DIFFERENTIATION 8 292 0.0002258 0.004648
227 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 6 156 0.000236 0.004837
228 ENDOCARDIAL CUSHION MORPHOGENESIS 3 22 0.0002373 0.004839
229 MITOTIC DNA INTEGRITY CHECKPOINT 5 100 0.0002381 0.004839
230 TISSUE DEVELOPMENT 20 1518 0.0002392 0.00484
231 NEGATIVE REGULATION OF CELL ADHESION 7 223 0.0002481 0.004998
232 NEURON NEURON SYNAPTIC TRANSMISSION 4 56 0.0002643 0.0053
233 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 13 750 0.0002663 0.005319
234 REGULATION OF NUCLEASE ACTIVITY 3 23 0.0002717 0.005404
235 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 103 0.0002733 0.005411
236 REGULATION OF CELL CYCLE PROCESS 11 558 0.0002756 0.005433
237 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 10 470 0.0002896 0.005685
238 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 7 229 0.0002915 0.0057
239 REGULATION OF CYTOKINE PRODUCTION 11 563 0.0002973 0.005764
240 RESPONSE TO WOUNDING 11 563 0.0002973 0.005764
241 REGULATION OF DEFENSE RESPONSE 13 759 0.0002987 0.005768
242 REGULATION OF MAPK CASCADE 12 660 0.0003021 0.005809
243 CELL SUBSTRATE ADHESION 6 164 0.0003088 0.005874
244 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 3 24 0.0003093 0.005874
245 REGULATION OF EXECUTION PHASE OF APOPTOSIS 3 24 0.0003093 0.005874
246 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 5 106 0.0003122 0.005905
247 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 14 867 0.0003152 0.005938
248 REGULATION OF CELLULAR COMPONENT BIOGENESIS 13 767 0.0003303 0.006197
249 PEPTIDE METABOLIC PROCESS 11 571 0.0003351 0.006262
250 REGULATION OF PEPTIDASE ACTIVITY 9 392 0.0003387 0.006305
251 IN UTERO EMBRYONIC DEVELOPMENT 8 311 0.0003449 0.006393
252 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 5 110 0.0003705 0.006816
253 IMMUNE RESPONSE 16 1100 0.0003706 0.006816
254 SCHWANN CELL DEVELOPMENT 3 26 0.0003941 0.00722
255 RESPONSE TO HORMONE 14 893 0.0004241 0.007738
256 NEURON DEVELOPMENT 12 687 0.0004332 0.007874
257 DEFENSE RESPONSE 17 1231 0.0004359 0.007875
258 GLIOGENESIS 6 175 0.0004366 0.007875
259 RESPONSE TO STEROID HORMONE 10 497 0.0004494 0.008074
260 REGULATION OF ION TRANSPORT 11 592 0.0004541 0.008127
261 POSITIVE REGULATION OF CELL CYCLE PROCESS 7 247 0.0004595 0.008193
262 REGULATION OF METAL ION TRANSPORT 8 325 0.000462 0.008204
263 CELL PROJECTION ORGANIZATION 14 902 0.0004686 0.00829
264 REGULATION OF AUTOPHAGY 7 249 0.0004822 0.008499
265 PLACENTA BLOOD VESSEL DEVELOPMENT 3 28 0.0004926 0.008617
266 AUDITORY RECEPTOR CELL DIFFERENTIATION 3 28 0.0004926 0.008617
267 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 4 66 0.000497 0.008628
268 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 4 66 0.000497 0.008628
269 NEGATIVE REGULATION OF PROTEOLYSIS 8 329 0.0005008 0.008662
270 LEUKOCYTE ACTIVATION 9 414 0.0005031 0.00867
271 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 16 1135 0.0005223 0.008968
272 POSITIVE REGULATION OF NEURON DEATH 4 67 0.0005263 0.009003
273 POSITIVE REGULATION OF CELL CYCLE 8 332 0.0005316 0.009061
274 PATTERN SPECIFICATION PROCESS 9 418 0.0005391 0.009154
275 ENDOCYTOSIS 10 509 0.0005411 0.009155
276 RESPONSE TO ARSENIC CONTAINING SUBSTANCE 3 29 0.0005473 0.009226
277 MULTI ORGANISM TRANSPORT 4 68 0.0005568 0.009303
278 POSITIVE REGULATION OF LOCOMOTION 9 420 0.0005578 0.009303
279 MULTI ORGANISM LOCALIZATION 4 68 0.0005568 0.009303
280 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 10 513 0.0005749 0.009553
281 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 8 337 0.0005864 0.009675
282 POSITIVE REGULATION OF DNA METABOLIC PROCESS 6 185 0.0005856 0.009675
NumGOOverlapSizeP ValueAdj. P Value
1 ENDOPEPTIDASE ACTIVITY 17 448 4.397e-10 4.085e-07
2 METALLOENDOPEPTIDASE ACTIVITY 9 113 1.327e-08 6.165e-06
3 PEPTIDASE ACTIVITY 18 663 2.489e-08 7.708e-06
4 METALLOPEPTIDASE ACTIVITY 9 188 1.048e-06 0.0001947
5 CELL ADHESION MOLECULE BINDING 9 186 9.586e-07 0.0001947
6 INTEGRIN BINDING 7 105 1.95e-06 0.0003019
7 ENZYME BINDING 26 1737 2.292e-06 0.0003042
8 EPHRIN RECEPTOR BINDING 4 24 8.765e-06 0.001018
9 PROTEIN DIMERIZATION ACTIVITY 19 1149 1.728e-05 0.001608
10 RECEPTOR BINDING 22 1476 1.731e-05 0.001608
11 BETA AMYLOID BINDING 4 35 4.12e-05 0.00348
12 SERINE HYDROLASE ACTIVITY 8 242 6.188e-05 0.00479
13 IDENTICAL PROTEIN BINDING 18 1209 0.0001146 0.007606
14 COFACTOR BINDING 8 263 0.0001104 0.007606
15 TRANSCRIPTION FACTOR BINDING 11 524 0.0001604 0.009934
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR MATRIX 16 426 1.741e-09 1.017e-06
2 PROTEINACEOUS EXTRACELLULAR MATRIX 11 356 4.711e-06 0.001376
3 PERINUCLEAR REGION OF CYTOPLASM 14 642 1.277e-05 0.002289
4 EXTRACELLULAR SPACE 21 1376 1.96e-05 0.002289
5 CELL BODY 12 494 1.942e-05 0.002289
6 CELL SURFACE 14 757 7.717e-05 0.007511
7 INTRINSIC COMPONENT OF PLASMA MEMBRANE 22 1649 9.221e-05 0.007693

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Notch_signaling_pathway_hsa04330 8 48 2.187e-10 1.137e-08
2 Apoptosis_hsa04210 8 138 1.018e-06 2.646e-05
3 Sphingolipid_signaling_pathway_hsa04071 7 118 4.257e-06 7.379e-05
4 Rap1_signaling_pathway_hsa04015 8 206 1.97e-05 0.0002561
5 Ras_signaling_pathway_hsa04014 8 232 4.598e-05 0.0004782
6 MAPK_signaling_pathway_hsa04010 8 295 0.0002419 0.002097
7 VEGF_signaling_pathway_hsa04370 4 59 0.0003233 0.002402
8 PI3K_Akt_signaling_pathway_hsa04151 7 352 0.003506 0.02279
9 cAMP_signaling_pathway_hsa04024 5 198 0.004969 0.02639
10 Focal_adhesion_hsa04510 5 199 0.005075 0.02639
11 Autophagy_animal_hsa04140 4 128 0.005659 0.02675
12 Necroptosis_hsa04217 4 164 0.01325 0.05741
13 Apoptosis_multiple_species_hsa04215 2 33 0.01441 0.05763
14 Lysosome_hsa04142 3 123 0.03116 0.1157
15 Mitophagy_animal_hsa04137 2 65 0.05064 0.1755
16 Adherens_junction_hsa04520 2 72 0.0607 0.1973
17 ErbB_signaling_pathway_hsa04012 2 85 0.08099 0.2477
18 HIF_1_signaling_pathway_hsa04066 2 100 0.1066 0.2993
19 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.1093 0.2993
20 FoxO_signaling_pathway_hsa04068 2 132 0.1666 0.4091
21 Apelin_signaling_pathway_hsa04371 2 137 0.1765 0.4091
22 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.1805 0.4091
23 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.1945 0.4091
24 Wnt_signaling_pathway_hsa04310 2 146 0.1945 0.4091
25 Neuroactive_ligand_receptor_interaction_hsa04080 3 278 0.2008 0.4091
26 mTOR_signaling_pathway_hsa04150 2 151 0.2045 0.4091
27 Cellular_senescence_hsa04218 2 160 0.2228 0.4214
28 Jak_STAT_signaling_pathway_hsa04630 2 162 0.2269 0.4214
29 Calcium_signaling_pathway_hsa04020 2 182 0.268 0.4805
30 Endocytosis_hsa04144 2 244 0.3933 0.6198

Quest ID: 33adc916a4dbaa28da4369640eb06695