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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-10b-5p INHBA -0.16 0.55501 1.44 0.01419 miRNAWalker2 validate -0.81 0 NA
2 hsa-miR-126-5p INHBA 0.9 2.0E-5 1.44 0.01419 mirMAP -0.27 0.04386 NA
3 hsa-miR-129-5p INHBA -0.52 0.22258 1.44 0.01419 miRanda -0.22 0.00128 NA
4 hsa-miR-148b-3p INHBA 1.98 0 1.44 0.01419 miRNAWalker2 validate -0.82 0 NA
5 hsa-miR-181c-5p INHBA 1.59 0 1.44 0.01419 mirMAP -0.48 2.0E-5 NA
6 hsa-miR-200b-3p INHBA 3.78 0 1.44 0.01419 TargetScan -0.41 0 NA
7 hsa-miR-224-3p INHBA 1.88 6.0E-5 1.44 0.01419 mirMAP -0.25 7.0E-5 NA
8 hsa-miR-23b-3p INHBA -0.25 0.1502 1.44 0.01419 mirMAP -0.52 0.00183 NA
9 hsa-miR-26b-5p INHBA 0.89 0 1.44 0.01419 mirMAP -0.48 0.00141 NA
10 hsa-miR-30b-5p INHBA 0.8 0.00013 1.44 0.01419 mirMAP -0.91 0 NA
11 hsa-miR-30c-5p INHBA 0.78 0.00029 1.44 0.01419 mirMAP -1.13 0 NA
12 hsa-miR-30d-5p INHBA 0.68 0.00271 1.44 0.01419 mirMAP -1.29 0 NA
13 hsa-miR-30e-5p INHBA 1.24 0 1.44 0.01419 mirMAP -1.37 0 NA
14 hsa-miR-335-3p INHBA 3.09 0 1.44 0.01419 mirMAP -0.13 0.04185 NA
15 hsa-miR-3607-3p INHBA 2.69 0 1.44 0.01419 mirMAP -0.27 0.00053 NA
16 hsa-miR-374a-5p INHBA 0.48 0.0043 1.44 0.01419 mirMAP -0.43 0.01227 NA
17 hsa-miR-421 INHBA 1.18 1.0E-5 1.44 0.01419 miRanda -0.28 0.0098 NA
18 hsa-miR-664a-3p INHBA 0.63 0.0052 1.44 0.01419 mirMAP -1.1 0 NA
19 hsa-miR-944 INHBA 2.91 0 1.44 0.01419 mirMAP -0.13 0.00765 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 36 1518 9.881e-22 4.597e-18
2 ORGAN MORPHOGENESIS 28 841 2.446e-20 5.69e-17
3 EMBRYO DEVELOPMENT 28 894 1.237e-19 1.919e-16
4 EMBRYONIC MORPHOGENESIS 23 539 5.735e-19 6.672e-16
5 PATTERN SPECIFICATION PROCESS 21 418 9.323e-19 8.676e-16
6 EPITHELIUM DEVELOPMENT 27 945 6.921e-18 5.367e-15
7 REGIONALIZATION 17 311 7.362e-16 4.894e-13
8 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 32 1784 1.632e-15 9.494e-13
9 CARDIOVASCULAR SYSTEM DEVELOPMENT 23 788 2.271e-15 1.057e-12
10 CIRCULATORY SYSTEM DEVELOPMENT 23 788 2.271e-15 1.057e-12
11 HEART DEVELOPMENT 19 466 2.504e-15 1.059e-12
12 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 14 207 1.833e-14 7.109e-12
13 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 21 689 2.098e-14 7.51e-12
14 GLAND DEVELOPMENT 17 395 3.782e-14 1.257e-11
15 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 13 190 1.475e-13 4.576e-11
16 ANTERIOR POSTERIOR PATTERN SPECIFICATION 13 194 1.93e-13 5.612e-11
17 SKELETAL SYSTEM DEVELOPMENT 17 455 3.742e-13 1.024e-10
18 POSITIVE REGULATION OF GENE EXPRESSION 28 1733 2.556e-12 6.606e-10
19 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 22 1004 3.378e-12 8.272e-10
20 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 28 1805 6.824e-12 1.588e-09
21 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 27 1672 7.468e-12 1.655e-09
22 RESPONSE TO GROWTH FACTOR 16 475 9.678e-12 1.958e-09
23 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 19 740 9.277e-12 1.958e-09
24 EMBRYONIC ORGAN DEVELOPMENT 15 406 1.276e-11 2.474e-09
25 NEGATIVE REGULATION OF GENE EXPRESSION 25 1493 2.722e-11 4.787e-09
26 REGULATION OF CELL DIFFERENTIATION 25 1492 2.683e-11 4.787e-09
27 CELL FATE COMMITMENT 12 227 2.881e-11 4.787e-09
28 REGULATION OF CELL PROLIFERATION 25 1496 2.843e-11 4.787e-09
29 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 17 602 3.184e-11 5.108e-09
30 TISSUE MORPHOGENESIS 16 533 5.38e-11 8.344e-09
31 TUBE DEVELOPMENT 16 552 9.023e-11 1.312e-08
32 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 9 100 8.876e-11 1.312e-08
33 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 16 554 9.517e-11 1.342e-08
34 TUBE MORPHOGENESIS 13 323 1.205e-10 1.649e-08
35 ACTIVIN RECEPTOR SIGNALING PATHWAY 6 22 1.254e-10 1.667e-08
36 SEX DIFFERENTIATION 12 266 1.81e-10 2.339e-08
37 HEART MORPHOGENESIS 11 212 2.513e-10 3.16e-08
38 EMBRYONIC ORGAN MORPHOGENESIS 12 279 3.131e-10 3.759e-08
39 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 18 801 3.15e-10 3.759e-08
40 SPECIFICATION OF SYMMETRY 9 117 3.672e-10 4.271e-08
41 NEGATIVE REGULATION OF CELL DIFFERENTIATION 16 609 3.806e-10 4.319e-08
42 MESODERM DEVELOPMENT 9 118 3.963e-10 4.391e-08
43 PALATE DEVELOPMENT 8 85 7.294e-10 7.893e-08
44 MORPHOGENESIS OF AN EPITHELIUM 13 400 1.644e-09 1.663e-07
45 RESPONSE TO BMP 8 94 1.644e-09 1.663e-07
46 CELLULAR RESPONSE TO BMP STIMULUS 8 94 1.644e-09 1.663e-07
47 POSITIVE REGULATION OF CELL COMMUNICATION 23 1532 1.845e-09 1.827e-07
48 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 20 1142 2.09e-09 2.026e-07
49 GROWTH 13 410 2.215e-09 2.104e-07
50 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 18 957 5.289e-09 4.922e-07
51 NEGATIVE REGULATION OF CELL PROLIFERATION 15 643 7.29e-09 6.651e-07
52 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 22 1517 8.764e-09 7.842e-07
53 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 10 229 9.176e-09 7.89e-07
54 ARTERY DEVELOPMENT 7 75 9.495e-09 7.89e-07
55 MAMMARY GLAND DEVELOPMENT 8 117 9.435e-09 7.89e-07
56 UROGENITAL SYSTEM DEVELOPMENT 11 299 9.334e-09 7.89e-07
57 EPITHELIAL CELL DIFFERENTIATION 13 495 2.093e-08 1.709e-06
58 REPRODUCTIVE SYSTEM DEVELOPMENT 12 408 2.252e-08 1.807e-06
59 DEVELOPMENTAL GROWTH 11 333 2.826e-08 2.229e-06
60 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 15 724 3.526e-08 2.734e-06
61 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 7 95 4.994e-08 3.809e-06
62 MALE SEX DIFFERENTIATION 8 148 5.964e-08 4.476e-06
63 EMBRYONIC PATTERN SPECIFICATION 6 58 6.145e-08 4.538e-06
64 REGULATION OF EPITHELIAL CELL PROLIFERATION 10 285 7.26e-08 5.278e-06
65 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 17 1008 7.509e-08 5.375e-06
66 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 9 216 7.989e-08 5.632e-06
67 GASTRULATION 8 155 8.537e-08 5.929e-06
68 EMBRYONIC HEART TUBE MORPHOGENESIS 6 62 9.227e-08 6.314e-06
69 CELL PROLIFERATION 14 672 1.007e-07 6.734e-06
70 REPRODUCTION 19 1297 1.013e-07 6.734e-06
71 VASCULATURE DEVELOPMENT 12 469 1.032e-07 6.763e-06
72 RESPONSE TO ENDOGENOUS STIMULUS 20 1450 1.147e-07 7.41e-06
73 POSITIVE REGULATION OF RESPONSE TO STIMULUS 23 1929 1.396e-07 8.898e-06
74 MORPHOGENESIS OF A BRANCHING STRUCTURE 8 167 1.518e-07 9.546e-06
75 APPENDAGE DEVELOPMENT 8 169 1.664e-07 1.019e-05
76 LIMB DEVELOPMENT 8 169 1.664e-07 1.019e-05
77 POSITIVE REGULATION OF CELL DIFFERENTIATION 15 823 1.869e-07 1.129e-05
78 FEMALE SEX DIFFERENTIATION 7 116 1.985e-07 1.184e-05
79 EMBRYONIC HEART TUBE DEVELOPMENT 6 73 2.477e-07 1.459e-05
80 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 7 122 2.803e-07 1.63e-05
81 ENDOCRINE SYSTEM DEVELOPMENT 7 123 2.964e-07 1.702e-05
82 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 19 1395 3.143e-07 1.784e-05
83 KIDNEY EPITHELIUM DEVELOPMENT 7 125 3.308e-07 1.855e-05
84 REGULATION OF GROWTH 13 633 3.606e-07 1.998e-05
85 MESENCHYME DEVELOPMENT 8 190 4.076e-07 2.231e-05
86 CELL DEVELOPMENT 19 1426 4.405e-07 2.384e-05
87 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 7 131 4.552e-07 2.434e-05
88 NEGATIVE REGULATION OF CELL COMMUNICATION 17 1192 8.049e-07 4.256e-05
89 CARDIAC CHAMBER DEVELOPMENT 7 144 8.634e-07 4.415e-05
90 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 7 144 8.634e-07 4.415e-05
91 MESONEPHROS DEVELOPMENT 6 90 8.634e-07 4.415e-05
92 IMMUNE SYSTEM DEVELOPMENT 12 582 1.029e-06 5.195e-05
93 DIGESTIVE SYSTEM DEVELOPMENT 7 148 1.038e-06 5.195e-05
94 POSITIVE REGULATION OF REPRODUCTIVE PROCESS 5 52 1.196e-06 5.922e-05
95 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 21 1848 1.284e-06 6.29e-05
96 POSITIVE REGULATION OF ERYTHROCYTE DIFFERENTIATION 4 23 1.298e-06 6.291e-05
97 MAMMARY GLAND EPITHELIUM DEVELOPMENT 5 53 1.317e-06 6.319e-05
98 NEUROGENESIS 18 1402 1.629e-06 7.733e-05
99 IN UTERO EMBRYONIC DEVELOPMENT 9 311 1.707e-06 8.023e-05
100 OUTFLOW TRACT MORPHOGENESIS 5 56 1.739e-06 8.091e-05
101 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 15 983 1.762e-06 8.119e-05
102 REGULATION OF ACTIVIN RECEPTOR SIGNALING PATHWAY 4 25 1.844e-06 8.413e-05
103 POSITIVE REGULATION OF HEMOPOIESIS 7 163 1.982e-06 8.954e-05
104 CARDIAC CHAMBER MORPHOGENESIS 6 104 2.022e-06 9.048e-05
105 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 16 1135 2.108e-06 9.344e-05
106 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 5 60 2.459e-06 0.0001079
107 EMBRYONIC DIGIT MORPHOGENESIS 5 61 2.671e-06 0.0001161
108 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 15 1036 3.363e-06 0.0001436
109 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 15 1036 3.363e-06 0.0001436
110 EMBRYONIC HINDLIMB MORPHOGENESIS 4 29 3.425e-06 0.0001449
111 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 5 66 3.956e-06 0.0001629
112 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 18 1492 3.937e-06 0.0001629
113 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 5 66 3.956e-06 0.0001629
114 ORGAN GROWTH 5 68 4.589e-06 0.0001873
115 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 6 121 4.882e-06 0.0001975
116 MYELOID CELL DIFFERENTIATION 7 189 5.282e-06 0.0002119
117 STEM CELL DIFFERENTIATION 7 190 5.468e-06 0.0002175
118 POSITIVE REGULATION OF CELL PROLIFERATION 13 814 5.868e-06 0.0002314
119 ERYTHROCYTE HOMEOSTASIS 5 73 6.521e-06 0.000255
120 REGULATION OF REPRODUCTIVE PROCESS 6 129 7.064e-06 0.0002739
121 SKELETAL SYSTEM MORPHOGENESIS 7 201 7.907e-06 0.0003041
122 REGULATION OF ERYTHROCYTE DIFFERENTIATION 4 36 8.335e-06 0.0003179
123 RENAL TUBULE DEVELOPMENT 5 78 9.039e-06 0.0003419
124 HINDLIMB MORPHOGENESIS 4 37 9.319e-06 0.0003497
125 POSITIVE REGULATION OF CATENIN IMPORT INTO NUCLEUS 3 12 9.615e-06 0.0003579
126 SENSORY ORGAN DEVELOPMENT 10 493 1.031e-05 0.0003809
127 KIDNEY MORPHOGENESIS 5 82 1.155e-05 0.0004199
128 NEGATIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 5 82 1.155e-05 0.0004199
129 NEURON DIFFERENTIATION 13 874 1.258e-05 0.0004536
130 MAMMARY GLAND MORPHOGENESIS 4 40 1.279e-05 0.0004543
131 NEGATIVE REGULATION OF LYMPHOCYTE DIFFERENTIATION 4 40 1.279e-05 0.0004543
132 POSITIVE REGULATION OF OSSIFICATION 5 84 1.3e-05 0.0004582
133 RESPONSE TO ESTROGEN 7 218 1.341e-05 0.0004692
134 CARDIAC SEPTUM DEVELOPMENT 5 85 1.377e-05 0.0004782
135 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 4 41 1.414e-05 0.0004812
136 POSITIVE REGULATION OF KIDNEY DEVELOPMENT 4 41 1.414e-05 0.0004812
137 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 9 404 1.417e-05 0.0004812
138 CARTILAGE DEVELOPMENT 6 147 1.492e-05 0.0005029
139 MYELOID CELL HOMEOSTASIS 5 88 1.631e-05 0.000546
140 REGULATION OF HEMOPOIESIS 8 314 1.689e-05 0.0005615
141 CELL FATE DETERMINATION 4 43 1.713e-05 0.0005654
142 AXIS SPECIFICATION 5 90 1.82e-05 0.0005921
143 REGULATION OF CELLULAR COMPONENT MOVEMENT 12 771 1.813e-05 0.0005921
144 ENDOCRINE PROCESS 4 44 1.879e-05 0.0006073
145 GABAERGIC NEURON DIFFERENTIATION 3 15 1.973e-05 0.0006332
146 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 16 1360 2.082e-05 0.0006635
147 NEPHRON EPITHELIUM DEVELOPMENT 5 93 2.134e-05 0.0006755
148 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 7 236 2.237e-05 0.0006939
149 NEGATIVE REGULATION OF GROWTH 7 236 2.237e-05 0.0006939
150 EYE DEVELOPMENT 8 326 2.211e-05 0.0006939
151 REGULATION OF PROTEIN MODIFICATION PROCESS 18 1710 2.563e-05 0.0007897
152 GLAND MORPHOGENESIS 5 97 2.617e-05 0.000799
153 REGULATION OF ORGAN MORPHOGENESIS 7 242 2.627e-05 0.000799
154 ANTERIOR POSTERIOR AXIS SPECIFICATION 4 48 2.665e-05 8e-04
155 POSITIVE REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 4 48 2.665e-05 8e-04
156 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 5 99 2.888e-05 0.0008505
157 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 5 99 2.888e-05 0.0008505
158 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 5 99 2.888e-05 0.0008505
159 OSSIFICATION 7 251 3.317e-05 0.00097
160 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 5 102 3.335e-05 0.00097
161 ARTERY MORPHOGENESIS 4 51 3.395e-05 0.0009811
162 OSTEOBLAST DEVELOPMENT 3 18 3.511e-05 0.001002
163 SIGNAL TRANSDUCTION INVOLVED IN REGULATION OF GENE EXPRESSION 3 18 3.511e-05 0.001002
164 POSITIVE REGULATION OF PROTEIN IMPORT 5 104 3.662e-05 0.001039
165 ODONTOGENESIS 5 105 3.835e-05 0.001081
166 MESONEPHRIC TUBULE MORPHOGENESIS 4 53 3.956e-05 0.001105
167 HOMEOSTASIS OF NUMBER OF CELLS 6 175 3.989e-05 0.001105
168 CARDIAC VENTRICLE DEVELOPMENT 5 106 4.013e-05 0.001105
169 REGULATION OF CELL DEVELOPMENT 12 836 4.01e-05 0.001105
170 FOREBRAIN DEVELOPMENT 8 357 4.217e-05 0.001154
171 REGULATION OF OSSIFICATION 6 178 4.387e-05 0.001194
172 REGULATION OF KIDNEY DEVELOPMENT 4 55 4.583e-05 0.00124
173 RESPONSE TO ALCOHOL 8 362 4.652e-05 0.001251
174 FORMATION OF PRIMARY GERM LAYER 5 110 4.793e-05 0.001282
175 EMBRYONIC HEMOPOIESIS 3 20 4.88e-05 0.001298
176 REGULATION OF OSTEOBLAST DIFFERENTIATION 5 112 5.225e-05 0.001381
177 REGULATION OF CELL DEATH 16 1472 5.447e-05 0.001432
178 REGULATION OF EMBRYONIC DEVELOPMENT 5 114 5.685e-05 0.001486
179 MUSCLE TISSUE DEVELOPMENT 7 275 5.915e-05 0.001532
180 NEPHRON DEVELOPMENT 5 115 5.927e-05 0.001532
181 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 13 1021 6.349e-05 0.001632
182 STEM CELL PROLIFERATION 4 60 6.464e-05 0.001644
183 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 4 60 6.464e-05 0.001644
184 POSITIVE REGULATION OF MESONEPHROS DEVELOPMENT 3 22 6.559e-05 0.001659
185 CONNECTIVE TISSUE DEVELOPMENT 6 194 7.078e-05 0.00178
186 RESPONSE TO LIPID 12 888 7.171e-05 0.001794
187 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 5 121 7.55e-05 0.001879
188 RESPIRATORY SYSTEM DEVELOPMENT 6 197 7.704e-05 0.001907
189 REGULATION OF CELL GROWTH 8 391 7.979e-05 0.001964
190 INOSITOL LIPID MEDIATED SIGNALING 5 124 8.48e-05 0.002077
191 POSITIVE REGULATION OF SMOOTHENED SIGNALING PATHWAY 3 24 8.576e-05 0.002089
192 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 9 513 9.079e-05 0.0022
193 OSTEOBLAST DIFFERENTIATION 5 126 9.148e-05 0.002205
194 SOMATIC STEM CELL POPULATION MAINTENANCE 4 66 9.4e-05 0.002232
195 FOREBRAIN GENERATION OF NEURONS 4 66 9.4e-05 0.002232
196 MESODERM MORPHOGENESIS 4 66 9.4e-05 0.002232
197 FOREBRAIN REGIONALIZATION 3 25 9.72e-05 0.002261
198 NEURON PROJECTION GUIDANCE 6 205 9.593e-05 0.002261
199 THYROID GLAND DEVELOPMENT 3 25 9.72e-05 0.002261
200 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 3 25 9.72e-05 0.002261
201 NEGATIVE REGULATION OF HEMOPOIESIS 5 128 9.855e-05 0.002281
202 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 5 129 0.0001022 0.002355
203 REGULATION OF MESONEPHROS DEVELOPMENT 3 26 0.0001096 0.002488
204 REGULATION OF T CELL DIFFERENTIATION IN THYMUS 3 26 0.0001096 0.002488
205 REGULATION OF THYMOCYTE AGGREGATION 3 26 0.0001096 0.002488
206 REGULATION OF LYMPHOCYTE DIFFERENTIATION 5 132 0.0001139 0.002561
207 MAINTENANCE OF CELL NUMBER 5 132 0.0001139 0.002561
208 POSITIVE REGULATION OF TRANSPORT 12 936 0.0001181 0.002643
209 REGULATION OF MAPK CASCADE 10 660 0.0001212 0.002699
210 REGULATION OF CATENIN IMPORT INTO NUCLEUS 3 27 0.000123 0.002725
211 REGULATION OF WNT SIGNALING PATHWAY 7 310 0.0001249 0.002744
212 ENDODERM DEVELOPMENT 4 71 0.000125 0.002744
213 PROTEIN PHOSPHORYLATION 12 944 0.000128 0.002796
214 RESPONSE TO GONADOTROPIN 3 28 0.0001374 0.002987
215 CARDIAC MUSCLE TISSUE DEVELOPMENT 5 140 0.0001502 0.003251
216 LOCOMOTION 13 1114 0.0001525 0.003286
217 ODONTOGENESIS OF DENTIN CONTAINING TOOTH 4 75 0.0001547 0.003317
218 MUSCLE STRUCTURE DEVELOPMENT 8 432 0.0001587 0.003387
219 POSITIVE REGULATION OF MOLECULAR FUNCTION 17 1791 0.0001631 0.003466
220 REGULATION OF PHOSPHORUS METABOLIC PROCESS 16 1618 0.0001658 0.003507
221 DIENCEPHALON DEVELOPMENT 4 77 0.0001713 0.003591
222 REGULATION OF BMP SIGNALING PATHWAY 4 77 0.0001713 0.003591
223 HORMONE TRANSPORT 4 78 0.0001801 0.003741
224 SOMITE DEVELOPMENT 4 78 0.0001801 0.003741
225 RESPONSE TO ESTRADIOL 5 146 0.0001828 0.003766
226 RESPONSE TO WOUNDING 9 563 0.0001829 0.003766
227 CELL MOTILITY 11 835 0.0001852 0.00378
228 LOCALIZATION OF CELL 11 835 0.0001852 0.00378
229 REGULATION OF LEUKOCYTE DIFFERENTIATION 6 232 0.0001884 0.003828
230 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 0.0002059 0.004129
231 EMBRYONIC FORELIMB MORPHOGENESIS 3 32 0.0002059 0.004129
232 NEGATIVE REGULATION OF T CELL DIFFERENTIATION 3 32 0.0002059 0.004129
233 METANEPHROS DEVELOPMENT 4 81 0.0002083 0.004143
234 POSITIVE REGULATION OF MYELOID CELL DIFFERENTIATION 4 81 0.0002083 0.004143
235 HEAD DEVELOPMENT 10 709 0.0002167 0.004291
236 EMBRYONIC AXIS SPECIFICATION 3 33 0.0002259 0.004453
237 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 5 154 0.0002342 0.004599
238 LUNG EPITHELIUM DEVELOPMENT 3 34 0.0002471 0.004831
239 NEGATIVE REGULATION OF CELL DEATH 11 872 0.0002693 0.00522
240 CENTRAL NERVOUS SYSTEM DEVELOPMENT 11 872 0.0002693 0.00522
241 POSITIVE REGULATION OF MAPK CASCADE 8 470 0.000281 0.005402
242 WOUND HEALING 8 470 0.000281 0.005402
243 EPIDERMIS DEVELOPMENT 6 253 0.0003003 0.005726
244 EPITHELIAL CELL PROLIFERATION 4 89 0.0002992 0.005726
245 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 7 360 0.0003117 0.00592
246 CORONARY VASCULATURE DEVELOPMENT 3 37 0.0003184 0.006022
247 DORSAL VENTRAL PATTERN FORMATION 4 91 0.0003258 0.006137
248 POSITIVE REGULATION OF KINASE ACTIVITY 8 482 0.0003327 0.006155
249 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 6 258 0.0003333 0.006155
250 RESPONSE TO HORMONE 11 893 0.00033 0.006155
251 BLOOD VESSEL MORPHOGENESIS 7 364 0.0003332 0.006155
252 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 5 166 0.0003313 0.006155
253 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 7 365 0.0003387 0.006229
254 POSITIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 3 38 0.0003447 0.006291
255 MESENCHYME MORPHOGENESIS 3 38 0.0003447 0.006291
256 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 4 93 0.0003539 0.006433
257 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 7 368 0.0003558 0.006442
258 NEGATIVE REGULATION OF CELL GROWTH 5 170 0.0003696 0.006641
259 ERBB2 SIGNALING PATHWAY 3 39 0.0003725 0.006641
260 ANATOMICAL STRUCTURE MATURATION 3 39 0.0003725 0.006641
261 TRABECULA MORPHOGENESIS 3 39 0.0003725 0.006641
262 CANONICAL WNT SIGNALING PATHWAY 4 95 0.0003838 0.006817
263 MYELOID LEUKOCYTE DIFFERENTIATION 4 96 0.0003995 0.00704
264 CARDIOCYTE DIFFERENTIATION 4 96 0.0003995 0.00704
265 FORELIMB MORPHOGENESIS 3 40 0.0004017 0.007053
266 CELL CELL SIGNALING 10 767 0.000405 0.007084
267 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 8 498 0.0004135 0.007206
268 AORTA DEVELOPMENT 3 41 0.0004323 0.007505
269 LIPID PHOSPHORYLATION 4 99 0.000449 0.007766
270 REGULATION OF PROTEIN IMPORT 5 183 0.0005175 0.008918
271 REGULATION OF MUSCLE TISSUE DEVELOPMENT 4 103 0.0005217 0.008924
272 REGULATION OF MUSCLE ORGAN DEVELOPMENT 4 103 0.0005217 0.008924
273 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 3 44 0.0005329 0.009083
274 REGULATION OF BINDING 6 283 0.0005439 0.009237
275 PEPTIDYL TYROSINE MODIFICATION 5 186 0.0005571 0.009427
276 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 13 1275 0.0005634 0.009498
277 LUNG MORPHOGENESIS 3 45 0.0005695 0.009532
278 VENTRICULAR CARDIAC MUSCLE TISSUE DEVELOPMENT 3 45 0.0005695 0.009532
279 REGULATION OF FAT CELL DIFFERENTIATION 4 106 0.0005814 0.009696
280 NEURON PROJECTION MORPHOGENESIS 7 402 0.0006026 0.009978
281 REGULATION OF T CELL DIFFERENTIATION 4 107 0.0006024 0.009978
282 APOPTOTIC SIGNALING PATHWAY 6 289 0.0006072 0.009991
283 REGULATION OF ALPHA BETA T CELL DIFFERENTIATION 3 46 0.0006077 0.009991
NumGOOverlapSizeP ValueAdj. P Value
1 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 28 1199 2.592e-16 2.408e-13
2 SEQUENCE SPECIFIC DNA BINDING 25 1037 8.197e-15 3.808e-12
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 19 629 5.412e-13 1.676e-10
4 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 9 81 1.285e-11 2.984e-09
5 REGULATORY REGION NUCLEIC ACID BINDING 18 818 4.413e-10 8.2e-08
6 GROWTH FACTOR BINDING 9 123 5.751e-10 8.905e-08
7 DOUBLE STRANDED DNA BINDING 16 764 9.804e-09 1.295e-06
8 RECEPTOR SIGNALING PROTEIN ACTIVITY 9 172 1.116e-08 1.295e-06
9 TRANSFORMING GROWTH FACTOR BETA RECEPTOR BINDING 6 50 2.468e-08 2.547e-06
10 ACTIVIN BINDING 4 12 7.476e-08 6.946e-06
11 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE ACTIVITY 4 17 3.546e-07 2.995e-05
12 RECEPTOR BINDING 19 1476 7.448e-07 5.766e-05
13 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 9 315 1.896e-06 0.0001342
14 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 6 104 2.022e-06 0.0001342
15 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 7 168 2.424e-06 0.0001444
16 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 9 328 2.642e-06 0.0001444
17 TRANSCRIPTION FACTOR BINDING 11 524 2.564e-06 0.0001444
18 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 5 64 3.394e-06 0.0001752
19 SMAD BINDING 5 72 6.091e-06 0.0002829
20 CYTOKINE RECEPTOR BINDING 8 271 5.795e-06 0.0002829
21 CORE PROMOTER PROXIMAL REGION DNA BINDING 9 371 7.173e-06 0.0003173
22 CO SMAD BINDING 3 12 9.615e-06 0.000406
23 PROTEIN KINASE ACTIVITY 11 640 1.696e-05 0.0006851
24 PROTEIN TYROSINE KINASE ACTIVITY 6 176 4.118e-05 0.001594
25 KINASE ACTIVITY 12 842 4.298e-05 0.001597
26 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 10 588 4.651e-05 0.001662
27 R SMAD BINDING 3 23 7.523e-05 0.002589
28 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 70 0.0001183 0.003925
29 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 6 226 0.0001634 0.005152
30 CHROMATIN BINDING 8 435 0.0001664 0.005152
31 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 12 992 0.0002031 0.006087
32 RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 3 36 0.0002933 0.008257
33 FRIZZLED BINDING 3 36 0.0002933 0.008257
34 SIGNAL TRANSDUCER ACTIVITY 16 1731 0.0003576 0.009229
35 ENHANCER BINDING 4 93 0.0003539 0.009229
36 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 4 92 0.0003396 0.009229
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTION FACTOR COMPLEX 11 298 9.016e-09 5.265e-06
2 PROTEINACEOUS EXTRACELLULAR MATRIX 10 356 5.666e-07 0.0001655
3 EXTRACELLULAR MATRIX 10 426 2.855e-06 0.0004168
4 RECEPTOR COMPLEX 9 327 2.576e-06 0.0004168

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04350_TGF.beta_signaling_pathway 5 85 1.377e-05 0.002479
2 hsa04340_Hedgehog_signaling_pathway 4 56 4.922e-05 0.00443
3 hsa04014_Ras_signaling_pathway 6 236 0.0002066 0.01234
4 hsa04012_ErbB_signaling_pathway 4 87 0.0002743 0.01234
5 hsa04144_Endocytosis 5 203 0.0008268 0.02976
6 hsa04151_PI3K_AKT_signaling_pathway 6 351 0.001652 0.04957
7 hsa04310_Wnt_signaling_pathway 4 151 0.002157 0.05226
8 hsa04520_Adherens_junction 3 73 0.002323 0.05226
9 hsa04974_Protein_digestion_and_absorption 3 81 0.003122 0.06243
10 hsa04510_Focal_adhesion 4 200 0.005878 0.1058
11 hsa04390_Hippo_signaling_pathway 3 154 0.01813 0.2967
12 hsa04020_Calcium_signaling_pathway 3 177 0.02604 0.3906
13 hsa00982_Drug_metabolism_._cytochrome_P450 2 73 0.0285 0.3946
14 hsa04916_Melanogenesis 2 101 0.05137 0.6604
15 hsa04910_Insulin_signaling_pathway 2 138 0.08843 0.8843
16 hsa04010_MAPK_signaling_pathway 2 268 0.2512 1

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 LINC00702 hsa-miR-10b-5p;hsa-miR-126-5p;hsa-miR-129-5p;hsa-miR-148b-3p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-335-3p;hsa-miR-421;hsa-miR-664a-3p 15 INHBA Sponge network -2.704 0 1.441 0.01419 0.477
2 RP11-253E3.3 hsa-miR-10b-5p;hsa-miR-148b-3p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-26b-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-3607-3p 10 INHBA Sponge network -0.01 0.98061 1.441 0.01419 0.476
3 RP11-166D19.1 hsa-miR-10b-5p;hsa-miR-126-5p;hsa-miR-129-5p;hsa-miR-148b-3p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-335-3p;hsa-miR-3607-3p;hsa-miR-374a-5p;hsa-miR-421;hsa-miR-664a-3p;hsa-miR-944 14 INHBA Sponge network -3.855 0 1.441 0.01419 0.453
4 FAM225B hsa-miR-10b-5p;hsa-miR-148b-3p;hsa-miR-200b-3p;hsa-miR-23b-3p;hsa-miR-26b-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-3607-3p;hsa-miR-664a-3p 11 INHBA Sponge network 0.864 0.07672 1.441 0.01419 0.447
5 GAS6-AS2 hsa-miR-10b-5p;hsa-miR-126-5p;hsa-miR-148b-3p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-335-3p;hsa-miR-421;hsa-miR-664a-3p 10 INHBA Sponge network -2.655 0 1.441 0.01419 0.433
6 APCDD1L-AS1 hsa-miR-10b-5p;hsa-miR-126-5p;hsa-miR-148b-3p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-335-3p;hsa-miR-3607-3p;hsa-miR-664a-3p 10 INHBA Sponge network -2.022 0.00702 1.441 0.01419 0.41
7 NR2F1-AS1 hsa-miR-10b-5p;hsa-miR-126-5p;hsa-miR-148b-3p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-3607-3p;hsa-miR-374a-5p;hsa-miR-421;hsa-miR-664a-3p;hsa-miR-944 12 INHBA Sponge network -1.881 0 1.441 0.01419 0.354
8 MAGI2-AS3 hsa-miR-126-5p;hsa-miR-148b-3p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-335-3p;hsa-miR-3607-3p;hsa-miR-374a-5p;hsa-miR-421;hsa-miR-664a-3p;hsa-miR-944 16 INHBA Sponge network -2.414 0 1.441 0.01419 0.343
9 RP11-536K7.3 hsa-miR-10b-5p;hsa-miR-129-5p;hsa-miR-148b-3p;hsa-miR-200b-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-335-3p;hsa-miR-374a-5p 10 INHBA Sponge network -0.673 0.17143 1.441 0.01419 0.336
10 ZFHX4-AS1 hsa-miR-126-5p;hsa-miR-148b-3p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-421;hsa-miR-944 12 INHBA Sponge network -2.966 0.00743 1.441 0.01419 0.334
11 RASSF8-AS1 hsa-miR-148b-3p;hsa-miR-200b-3p;hsa-miR-23b-3p;hsa-miR-26b-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-3607-3p;hsa-miR-664a-3p;hsa-miR-944 11 INHBA Sponge network -0.877 0.00508 1.441 0.01419 0.323
12 LINC00327 hsa-miR-10b-5p;hsa-miR-126-5p;hsa-miR-148b-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-3607-3p;hsa-miR-421;hsa-miR-664a-3p;hsa-miR-944 13 INHBA Sponge network -1.951 0.01135 1.441 0.01419 0.319
13 TBX5-AS1 hsa-miR-10b-5p;hsa-miR-148b-3p;hsa-miR-200b-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-335-3p;hsa-miR-374a-5p;hsa-miR-421;hsa-miR-664a-3p;hsa-miR-944 10 INHBA Sponge network -2.557 2.0E-5 1.441 0.01419 0.308
14 HAND2-AS1 hsa-miR-10b-5p;hsa-miR-126-5p;hsa-miR-129-5p;hsa-miR-148b-3p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-335-3p;hsa-miR-3607-3p;hsa-miR-374a-5p;hsa-miR-421;hsa-miR-664a-3p;hsa-miR-944 18 INHBA Sponge network -5.605 0 1.441 0.01419 0.279
15 ACTA2-AS1 hsa-miR-10b-5p;hsa-miR-126-5p;hsa-miR-129-5p;hsa-miR-148b-3p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-335-3p;hsa-miR-944 10 INHBA Sponge network -3.838 0 1.441 0.01419 0.275
16 RP1-151F17.2 hsa-miR-126-5p;hsa-miR-148b-3p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-26b-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-335-3p;hsa-miR-3607-3p;hsa-miR-374a-5p;hsa-miR-421 13 INHBA Sponge network -1.606 0 1.441 0.01419 0.265
17 MIR143HG hsa-miR-10b-5p;hsa-miR-126-5p;hsa-miR-129-5p;hsa-miR-148b-3p;hsa-miR-181c-5p;hsa-miR-200b-3p;hsa-miR-224-3p;hsa-miR-26b-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-335-3p;hsa-miR-3607-3p;hsa-miR-374a-5p;hsa-miR-664a-3p;hsa-miR-944 17 INHBA Sponge network -4.237 0 1.441 0.01419 0.263

Quest ID: 35882a2729057e5c160b3a1cb43e15f5