Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-320c ABCA12 -0.2 0.68946 5.05 3.0E-5 miRanda; miRNATAP -0.4 0.03911 NA
2 hsa-miR-320c ABCA13 -0.2 0.68946 2.71 0.0092 miRanda -0.34 0.03989 NA
3 hsa-miR-628-3p ABCA13 -1.92 0.00404 2.71 0.0092 MirTarget -0.5 1.0E-5 NA
4 hsa-miR-320b ABCA4 -0.27 0.55127 0.62 0.41421 miRanda -0.28 0.02169 NA
5 hsa-miR-320b ABCA8 -0.27 0.55127 -0.99 0.28561 miRanda -0.43 0.00409 NA
6 hsa-miR-320b ACAT1 -0.27 0.55127 -0.37 0.29673 miRanda -0.14 0.01018 NA
7 hsa-miR-320b ACSBG1 -0.27 0.55127 0.18 0.71848 mirMAP -0.18 0.02327 NA
8 hsa-miR-320b ACSM5 -0.27 0.55127 -2.35 0.00202 miRanda -0.26 0.03838 NA
9 hsa-miR-320c ACVR1B -0.2 0.68946 0.33 0.28594 mirMAP -0.12 0.01262 NA
10 hsa-miR-628-3p ADAM28 -1.92 0.00404 -0.09 0.91558 mirMAP -0.23 0.00993 NA
11 hsa-miR-320b ADAMTS3 -0.27 0.55127 -0.85 0.21039 mirMAP -0.24 0.02841 NA
12 hsa-miR-320c ADAMTS9 -0.2 0.68946 -0.6 0.25854 miRanda -0.17 0.03445 NA
13 hsa-miR-320b ADAMTSL1 -0.27 0.55127 -0.36 0.58349 miRanda; mirMAP -0.35 0.00079 NA
14 hsa-miR-320c ADAMTSL1 -0.2 0.68946 -0.36 0.58349 miRanda; mirMAP -0.21 0.03825 NA
15 hsa-miR-320b ADCY5 -0.27 0.55127 -1.65 0.0474 mirMAP -0.38 0.00495 NA
16 hsa-miR-320b ADCYAP1 -0.27 0.55127 0.97 0.41593 PITA; miRanda; miRNATAP -0.62 0.0011 NA
17 hsa-miR-320c ADCYAP1 -0.2 0.68946 0.97 0.41593 PITA; miRanda; miRNATAP -0.46 0.01306 NA
18 hsa-miR-320b ADIPOQ -0.27 0.55127 -0.32 0.88686 miRanda -0.91 0.01073 NA
19 hsa-miR-320b ADRB2 -0.27 0.55127 -1.26 0.05752 miRanda -0.22 0.03809 NA
20 hsa-miR-320b AGPAT4 -0.27 0.55127 -0.6 0.10553 mirMAP -0.16 0.00642 NA
21 hsa-miR-320c AGPAT4 -0.2 0.68946 -0.6 0.10553 mirMAP -0.19 0.00071 NA
22 hsa-miR-320b AKAP7 -0.27 0.55127 -1.69 0.0192 miRanda -0.35 0.00254 NA
23 hsa-miR-320b ALB -0.27 0.55127 -0.29 0.86747 miRanda -0.88 0.0018 NA
24 hsa-miR-320c ALB -0.2 0.68946 -0.29 0.86747 miRanda -0.55 0.0446 NA
25 hsa-miR-320b ALDH1A3 -0.27 0.55127 0.26 0.72786 miRanda -0.33 0.00547 NA
26 hsa-miR-320c ALDH1A3 -0.2 0.68946 0.26 0.72786 miRanda -0.29 0.01101 NA
27 hsa-miR-320b ALX3 -0.27 0.55127 -0.46 0.18571 miRanda -0.12 0.03124 NA
28 hsa-miR-320b AMOTL2 -0.27 0.55127 -0.28 0.48817 miRanda -0.18 0.00512 NA
29 hsa-miR-320b AMY2B -0.27 0.55127 0.38 0.79652 miRanda -0.62 0.00958 NA
30 hsa-miR-628-3p ANGPT2 -1.92 0.00404 0.67 0.18404 mirMAP -0.17 0.00271 NA
31 hsa-miR-320b ANGPTL1 -0.27 0.55127 -0.94 0.28852 miRanda; miRNATAP -0.56 8.0E-5 NA
32 hsa-miR-320c ANGPTL1 -0.2 0.68946 -0.94 0.28852 miRanda; miRNATAP -0.35 0.01122 NA
33 hsa-miR-320b ANKDD1A -0.27 0.55127 -1.01 0.00294 miRanda -0.12 0.03268 NA
34 hsa-miR-320b AOX1 -0.27 0.55127 -0.25 0.79739 miRanda -0.37 0.01876 NA
35 hsa-miR-320b APBB2 -0.27 0.55127 -0.11 0.68147 mirMAP; miRNATAP -0.13 0.00326 NA
36 hsa-miR-320b AQP1 -0.27 0.55127 -0.55 0.38531 miRanda; mirMAP -0.43 2.0E-5 NA
37 hsa-miR-320c AQP1 -0.2 0.68946 -0.55 0.38531 miRanda; mirMAP -0.2 0.04418 NA
38 hsa-miR-628-3p AR -1.92 0.00404 -0.52 0.55352 mirMAP -0.36 0.00018 NA
39 hsa-miR-320b ARHGAP22 -0.27 0.55127 -1.05 0.01856 miRanda -0.2 0.00607 NA
40 hsa-miR-320b ARHGAP28 -0.27 0.55127 -1.8 0.00384 miRanda -0.28 0.0052 NA
41 hsa-miR-320b ARHGAP31 -0.27 0.55127 -0.77 0.05205 miRanda -0.14 0.02871 NA
42 hsa-miR-320c ARHGAP36 -0.2 0.68946 1.27 0.28003 miRanda -0.39 0.03315 NA
43 hsa-miR-320c ARHGEF3 -0.2 0.68946 -0.23 0.42978 mirMAP -0.11 0.01708 NA
44 hsa-miR-628-3p ARID5B -1.92 0.00404 -0.68 0.07996 PITA -0.12 0.00425 NA
45 hsa-miR-628-3p ARL10 -1.92 0.00404 -0.61 0.19487 mirMAP -0.14 0.00809 NA
46 hsa-miR-320b ARL3 -0.27 0.55127 0.47 0.07862 miRanda -0.1 0.01672 NA
47 hsa-miR-320b ARMC9 -0.27 0.55127 0.48 0.14649 miRanda -0.12 0.02741 NA
48 hsa-miR-320c ARMC9 -0.2 0.68946 0.48 0.14649 miRanda -0.17 0.00094 NA
49 hsa-miR-320b ARMCX2 -0.27 0.55127 -0.35 0.32454 MirTarget; PITA; miRanda; miRNATAP -0.12 0.03561 NA
50 hsa-miR-320b ASAP3 -0.27 0.55127 -0.18 0.62165 miRanda -0.18 0.00247 NA
51 hsa-miR-320b ASPA -0.27 0.55127 -0.75 0.31835 miRanda -0.27 0.0281 NA
52 hsa-miR-628-3p ASXL2 -1.92 0.00404 -0.21 0.72028 mirMAP -0.19 0.00356 NA
53 hsa-miR-628-3p ATL3 -1.92 0.00404 0.39 0.29173 mirMAP -0.2 0 NA
54 hsa-miR-320c ATXN1 -0.2 0.68946 -0.51 0.09797 mirMAP; miRNATAP -0.11 0.02494 NA
55 hsa-miR-628-3p ATXN1 -1.92 0.00404 -0.51 0.09797 PITA; mirMAP -0.1 0.00206 NA
56 hsa-miR-320b AVPR1A -0.27 0.55127 -0.5 0.53596 miRanda -0.26 0.04402 NA
57 hsa-miR-320b B3GALT2 -0.27 0.55127 -0.17 0.84294 miRanda -0.28 0.04036 NA
58 hsa-miR-320b B4GALT2 -0.27 0.55127 0.64 0.01587 mirMAP -0.12 0.00376 NA
59 hsa-miR-320b BACE1 -0.27 0.55127 -0.04 0.93251 miRanda; mirMAP -0.24 0.00048 NA
60 hsa-miR-320b BCAT1 -0.27 0.55127 -0.37 0.61191 MirTarget; miRanda; miRNATAP -0.38 0.00106 NA
61 hsa-miR-320c BCAT1 -0.2 0.68946 -0.37 0.61191 MirTarget; miRanda; miRNATAP -0.26 0.02061 NA
62 hsa-miR-320b BCHE -0.27 0.55127 -0.47 0.52691 miRanda -0.36 0.00281 NA
63 hsa-miR-320c BEND7 -0.2 0.68946 0.53 0.23121 mirMAP -0.18 0.00966 NA
64 hsa-miR-320b BEX2 -0.27 0.55127 -0.11 0.89364 miRanda -0.28 0.03535 NA
65 hsa-miR-320b BHLHE22 -0.27 0.55127 -0.66 0.3246 miRanda; miRNATAP -0.26 0.01488 NA
66 hsa-miR-320b BLMH -0.27 0.55127 -0.47 0.07946 miRanda -0.12 0.00356 NA
67 hsa-miR-320c BMP3 -0.2 0.68946 0.48 0.63183 miRanda; miRNATAP -0.37 0.01471 NA
68 hsa-miR-320b BMP6 -0.27 0.55127 -0.35 0.52285 PITA; miRanda -0.18 0.03458 NA
69 hsa-miR-320b BNIP3 -0.27 0.55127 -0.11 0.85548 miRanda -0.23 0.01227 NA
70 hsa-miR-320b BRSK2 -0.27 0.55127 0.35 0.73993 miRanda -0.38 0.02488 NA
71 hsa-miR-628-3p BRWD3 -1.92 0.00404 -0.24 0.56965 mirMAP -0.12 0.0091 NA
72 hsa-miR-320c BVES -0.2 0.68946 -0.04 0.94915 miRanda; miRNATAP -0.26 0.00567 NA
73 hsa-miR-320b C1QTNF9 -0.27 0.55127 -0.87 0.26652 miRanda -0.29 0.02204 NA
74 hsa-miR-320b C3orf70 -0.27 0.55127 -0.08 0.87525 mirMAP -0.17 0.03788 NA
75 hsa-miR-320c C5AR1 -0.2 0.68946 -0.96 0.10709 miRanda -0.23 0.01308 NA
76 hsa-miR-320b C6 -0.27 0.55127 -0.15 0.91761 miRanda -0.54 0.01949 NA
77 hsa-miR-320c C6 -0.2 0.68946 -0.15 0.91761 miRanda -0.57 0.01087 NA
78 hsa-miR-320b CADM3 -0.27 0.55127 -0.93 0.38425 mirMAP -0.36 0.03917 NA
79 hsa-miR-320c CALD1 -0.2 0.68946 -0.37 0.4868 PITA; miRanda; miRNATAP -0.21 0.00975 NA
80 hsa-miR-320c CAP2 -0.2 0.68946 -0.08 0.87315 miRanda -0.17 0.02498 NA
81 hsa-miR-320b CASQ2 -0.27 0.55127 0.07 0.9453 miRanda -0.36 0.03092 NA
82 hsa-miR-320c CASR -0.2 0.68946 0.92 0.48488 miRanda -0.46 0.02627 NA
83 hsa-miR-320b CBLN4 -0.27 0.55127 -0.42 0.6959 miRanda -0.47 0.00725 NA
84 hsa-miR-217 CCDC150 -1.53 0.33181 0.32 0.58012 miRanda -0.12 0 NA
85 hsa-miR-320b CCDC80 -0.27 0.55127 0.02 0.97481 miRanda -0.38 0.00136 NA
86 hsa-miR-320c CCL7 -0.2 0.68946 0.45 0.6631 miRanda -0.35 0.02754 NA
87 hsa-miR-628-3p CCNT1 -1.92 0.00404 -0.05 0.94372 mirMAP -0.18 0.0143 NA
88 hsa-miR-320b CCR1 -0.27 0.55127 -1.63 0.00703 miRanda -0.19 0.04808 NA
89 hsa-miR-320c CCR1 -0.2 0.68946 -1.63 0.00703 miRanda -0.19 0.04146 NA
90 hsa-miR-320c CD109 -0.2 0.68946 0.78 0.26548 miRanda -0.3 0.00495 NA
91 hsa-miR-628-3p CD109 -1.92 0.00404 0.78 0.26548 mirMAP -0.27 0.00035 NA
92 hsa-miR-320b CD2 -0.27 0.55127 -1.6 0.02925 miRanda -0.27 0.02452 NA
93 hsa-miR-320c CD244 -0.2 0.68946 -1.83 0.00402 miRanda -0.2 0.04173 NA
94 hsa-miR-320b CD74 -0.27 0.55127 -1.28 0.00731 miRanda -0.17 0.03144 NA
95 hsa-miR-320b CD93 -0.27 0.55127 -0.36 0.42563 miRanda -0.16 0.02355 NA
96 hsa-miR-217 CDH13 -1.53 0.33181 0.38 0.49466 PITA; miRanda -0.11 2.0E-5 NA
97 hsa-miR-320b CDH19 -0.27 0.55127 0.13 0.90694 miRanda -0.45 0.01087 NA
98 hsa-miR-320c CDH19 -0.2 0.68946 0.13 0.90694 miRanda -0.37 0.02778 NA
99 hsa-miR-320c CDH2 -0.2 0.68946 -0.86 0.27079 MirTarget; PITA; miRanda; miRNATAP -0.27 0.02447 NA
100 hsa-miR-320b CDH23 -0.27 0.55127 -1.68 0.00275 mirMAP -0.28 0.00178 NA
101 hsa-miR-217 CDHR3 -1.53 0.33181 0.77 0.31392 miRanda; mirMAP -0.14 7.0E-5 NA
102 hsa-miR-320b CDKN1C -0.27 0.55127 -0.25 0.60119 miRanda; miRNATAP -0.23 0.00251 NA
103 hsa-miR-320c CEACAM6 -0.2 0.68946 4.92 0.00132 miRanda -0.5 0.03701 NA
104 hsa-miR-320b CECR2 -0.27 0.55127 -1.11 0.14635 miRanda -0.38 0.00179 NA
105 hsa-miR-320c CECR2 -0.2 0.68946 -1.11 0.14635 miRanda -0.25 0.03649 NA
106 hsa-miR-320b CEP70 -0.27 0.55127 0.34 0.22537 miRanda -0.13 0.00369 NA
107 hsa-miR-628-3p CEP97 -1.92 0.00404 -0.01 0.98334 mirMAP -0.11 0.02529 NA
108 hsa-miR-320b CES1 -0.27 0.55127 -0.99 0.29047 miRanda -0.35 0.02016 NA
109 hsa-miR-320c CES1 -0.2 0.68946 -0.99 0.29047 miRanda -0.39 0.00698 NA
110 hsa-miR-320c CFL2 -0.2 0.68946 -0.4 0.27702 miRanda -0.12 0.04113 NA
111 hsa-miR-320b CHRNA3 -0.27 0.55127 0.57 0.48316 miRanda -0.41 0.00167 NA
112 hsa-miR-320c CHRNA3 -0.2 0.68946 0.57 0.48316 miRanda -0.36 0.00415 NA
113 hsa-miR-320b CHSY3 -0.27 0.55127 0.13 0.83083 miRanda -0.26 0.00712 NA
114 hsa-miR-320c CHSY3 -0.2 0.68946 0.13 0.83083 miRanda -0.25 0.00691 NA
115 hsa-miR-320b CITED4 -0.27 0.55127 -0.5 0.43325 miRanda -0.33 0.00132 NA
116 hsa-miR-320b CLEC10A -0.27 0.55127 -1.44 0.11723 miRanda -0.31 0.035 NA
117 hsa-miR-320b CLIC6 -0.27 0.55127 -0.84 0.21863 miRanda -0.26 0.01943 NA
118 hsa-miR-320c CLTCL1 -0.2 0.68946 -0.09 0.83269 miRanda -0.2 0.0042 NA
119 hsa-miR-320b CMKLR1 -0.27 0.55127 -1.34 0.03228 mirMAP -0.3 0.00334 NA
120 hsa-miR-320b CNKSR3 -0.27 0.55127 -0.49 0.14351 miRanda -0.11 0.04308 NA
121 hsa-miR-320b CNPY4 -0.27 0.55127 -0.24 0.42021 miRanda -0.11 0.02528 NA
122 hsa-miR-320b CNRIP1 -0.27 0.55127 -0.46 0.27355 miRanda -0.16 0.01723 NA
123 hsa-miR-320c CNTLN -0.2 0.68946 -0.26 0.40058 miRanda -0.1 0.026 NA
124 hsa-miR-320b CNTN4 -0.27 0.55127 0.52 0.4103 miRanda -0.23 0.02567 NA
125 hsa-miR-320b COL15A1 -0.27 0.55127 0.39 0.50342 miRanda -0.22 0.02093 NA
126 hsa-miR-320c COL15A1 -0.2 0.68946 0.39 0.50342 miRanda -0.21 0.01756 NA
127 hsa-miR-217 COL24A1 -1.53 0.33181 0.23 0.77217 miRanda -0.12 0.00101 NA
128 hsa-miR-320c COL24A1 -0.2 0.68946 0.23 0.77217 MirTarget; PITA; miRanda -0.3 0.01517 NA
129 hsa-miR-320b COL6A3 -0.27 0.55127 -0.1 0.89132 miRanda -0.24 0.04481 NA
130 hsa-miR-320c COL6A3 -0.2 0.68946 -0.1 0.89132 miRanda -0.24 0.03861 NA
131 hsa-miR-320b COLEC12 -0.27 0.55127 0.84 0.34512 miRanda -0.44 0.00202 NA
132 hsa-miR-320c COLEC12 -0.2 0.68946 0.84 0.34512 miRanda -0.33 0.01816 NA
133 hsa-miR-210-3p CORO2B 0.9 0.31127 -0.99 0.0863 MirTarget -0.36 0 NA
134 hsa-miR-217 COX6B2 -1.53 0.33181 2.77 0.01635 miRanda -0.12 0.02171 NA
135 hsa-miR-320c CPNE8 -0.2 0.68946 -0.03 0.94251 miRanda -0.16 0.02537 NA
136 hsa-miR-320c CRISP2 -0.2 0.68946 1.23 0.40235 miRanda -0.55 0.01668 NA
137 hsa-miR-320b CSMD2 -0.27 0.55127 -1.08 0.11919 miRanda -0.28 0.01239 NA
138 hsa-miR-320b CSRP2 -0.27 0.55127 -0.55 0.17968 miRanda -0.2 0.00246 NA
139 hsa-miR-320b CTRC -0.27 0.55127 -1.67 0.57111 mirMAP -1.61 0.00063 NA
140 hsa-miR-320c CTRC -0.2 0.68946 -1.67 0.57111 mirMAP -1.19 0.00933 NA
141 hsa-miR-628-3p CXADR -1.92 0.00404 1.16 0.06599 mirMAP -0.19 0.00554 NA
142 hsa-miR-320b CXCL12 -0.27 0.55127 -1.19 0.1171 miRanda -0.49 4.0E-5 NA
143 hsa-miR-320b CYBRD1 -0.27 0.55127 0.13 0.82152 miRanda -0.19 0.03745 NA
144 hsa-miR-216a-5p CYP4F3 -1.36 0.35361 2.8 0.0043 mirMAP -0.12 0.01713 NA
145 hsa-miR-320b CYTH3 -0.27 0.55127 -0.14 0.70009 miRNATAP -0.13 0.02405 NA
146 hsa-miR-320b CYTL1 -0.27 0.55127 0.69 0.30489 miRanda -0.32 0.00287 NA
147 hsa-miR-320c CYTL1 -0.2 0.68946 0.69 0.30489 miRanda -0.31 0.00262 NA
148 hsa-miR-320b CYYR1 -0.27 0.55127 -0.46 0.31996 miRanda -0.21 0.00588 NA
149 hsa-miR-320b DAB2 -0.27 0.55127 -0.78 0.05267 PITA; miRanda; miRNATAP -0.2 0.0017 NA
150 hsa-miR-320b DAPL1 -0.27 0.55127 -0.58 0.5983 miRanda -0.56 0.00149 NA
NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEVELOPMENT 98 1426 3.744e-15 1.742e-11
2 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 104 1672 3.009e-13 7e-10
3 NEUROGENESIS 89 1402 7.094e-12 1.1e-08
4 TISSUE DEVELOPMENT 93 1518 1.594e-11 1.854e-08
5 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 75 1142 8.436e-11 7.851e-08
6 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 85 1395 1.804e-10 1.399e-07
7 MUSCLE STRUCTURE DEVELOPMENT 39 432 8.134e-10 5.406e-07
8 CARDIOVASCULAR SYSTEM DEVELOPMENT 56 788 1.566e-09 7.285e-07
9 CIRCULATORY SYSTEM DEVELOPMENT 56 788 1.566e-09 7.285e-07
10 BIOLOGICAL ADHESION 67 1032 1.53e-09 7.285e-07
11 REGULATION OF CELL DIFFERENTIATION 86 1492 2.119e-09 8.962e-07
12 ORGAN MORPHOGENESIS 58 841 2.39e-09 9.266e-07
13 LOCOMOTION 69 1114 5.937e-09 2.125e-06
14 UROGENITAL SYSTEM DEVELOPMENT 30 299 6.835e-09 2.272e-06
15 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 75 1275 1.114e-08 2.881e-06
16 CELLULAR COMPONENT MORPHOGENESIS 59 900 1.112e-08 2.881e-06
17 NEURON DIFFERENTIATION 58 874 9.668e-09 2.881e-06
18 MUSCLE CELL DIFFERENTIATION 26 237 1.114e-08 2.881e-06
19 NEURON DEVELOPMENT 49 687 1.554e-08 3.615e-06
20 BLOOD VESSEL MORPHOGENESIS 33 364 1.505e-08 3.615e-06
21 HEART DEVELOPMENT 38 466 2.178e-08 4.827e-06
22 REGULATION OF NEURON DIFFERENTIATION 42 554 3.171e-08 6.706e-06
23 REGULATION OF CELLULAR COMPONENT MOVEMENT 52 771 3.501e-08 7.082e-06
24 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 39 513 9.261e-08 1.796e-05
25 REGULATION OF CHEMOTAXIS 21 180 1.002e-07 1.865e-05
26 SKELETAL SYSTEM DEVELOPMENT 36 455 1.096e-07 1.961e-05
27 POSITIVE REGULATION OF LOCOMOTION 34 420 1.447e-07 2.493e-05
28 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 58 957 2.222e-07 3.692e-05
29 VASCULATURE DEVELOPMENT 36 469 2.307e-07 3.702e-05
30 POSITIVE REGULATION OF CELL DIFFERENTIATION 52 823 2.758e-07 4.277e-05
31 EPITHELIUM DEVELOPMENT 57 945 3.325e-07 4.99e-05
32 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 60 1021 3.858e-07 5.61e-05
33 EMBRYONIC ORGAN DEVELOPMENT 32 406 6.102e-07 8.604e-05
34 CELL PROJECTION ORGANIZATION 54 902 8.693e-07 0.000119
35 STRIATED MUSCLE CELL DIFFERENTIATION 19 173 1.032e-06 0.0001264
36 CELL MOTILITY 51 835 9.914e-07 0.0001264
37 LOCALIZATION OF CELL 51 835 9.914e-07 0.0001264
38 REGULATION OF CELL DEVELOPMENT 51 836 1.027e-06 0.0001264
39 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 47 750 1.328e-06 0.0001584
40 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 49 801 1.561e-06 0.0001815
41 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 29 368 2.06e-06 0.0002338
42 CELLULAR HOMEOSTASIS 43 676 2.594e-06 0.0002874
43 REGULATION OF MAPK CASCADE 42 660 3.363e-06 0.0003589
44 CELLULAR CHEMICAL HOMEOSTASIS 38 570 3.394e-06 0.0003589
45 EMBRYONIC ORGAN MORPHOGENESIS 24 279 3.521e-06 0.000364
46 POSITIVE REGULATION OF LEUKOCYTE MIGRATION 14 109 4.355e-06 0.0004405
47 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 19 191 4.555e-06 0.0004509
48 SINGLE ORGANISM BEHAVIOR 29 384 4.762e-06 0.0004522
49 DIVALENT INORGANIC CATION HOMEOSTASIS 27 343 4.717e-06 0.0004522
50 POSITIVE REGULATION OF CELL PROLIFERATION 48 814 5.441e-06 0.0005063
51 BEHAVIOR 35 516 5.685e-06 0.0005187
52 EMBRYONIC DIGESTIVE TRACT MORPHOGENESIS 6 17 6.324e-06 0.0005552
53 MUSCLE CELL DEVELOPMENT 15 128 6.318e-06 0.0005552
54 CELL PART MORPHOGENESIS 40 633 6.819e-06 0.0005876
55 NEURON PROJECTION DEVELOPMENT 36 545 7.539e-06 0.0006378
56 ANGIOGENESIS 24 293 8.131e-06 0.0006756
57 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 55 1004 9.736e-06 0.0007948
58 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 80 1656 1.049e-05 0.0008416
59 TISSUE MORPHOGENESIS 35 533 1.144e-05 0.0008884
60 NEURON PROJECTION MORPHOGENESIS 29 402 1.146e-05 0.0008884
61 APPENDAGE DEVELOPMENT 17 169 1.238e-05 0.0009144
62 LIMB DEVELOPMENT 17 169 1.238e-05 0.0009144
63 CARDIAC SEPTUM MORPHOGENESIS 9 49 1.22e-05 0.0009144
64 VENTRICULAR SEPTUM MORPHOGENESIS 7 28 1.368e-05 0.0009574
65 SENSORY ORGAN DEVELOPMENT 33 493 1.379e-05 0.0009574
66 REGULATION OF TRANSPORT 85 1804 1.377e-05 0.0009574
67 POSITIVE REGULATION OF CHEMOTAXIS 14 120 1.348e-05 0.0009574
68 EMBRYONIC MORPHOGENESIS 35 539 1.452e-05 0.0009933
69 REGULATION OF NEURON PROJECTION DEVELOPMENT 29 408 1.513e-05 0.001021
70 CENTRAL NERVOUS SYSTEM DEVELOPMENT 49 872 1.571e-05 0.001044
71 GROWTH 29 410 1.658e-05 0.001087
72 REGULATION OF PROTEIN MODIFICATION PROCESS 81 1710 1.867e-05 0.001207
73 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 53 983 2.197e-05 0.0014
74 POSITIVE REGULATION OF CELL COMMUNICATION 74 1532 2.345e-05 0.001475
75 TUBE DEVELOPMENT 35 552 2.392e-05 0.001484
76 REGULATION OF SYSTEM PROCESS 33 507 2.426e-05 0.001486
77 MUSCLE TISSUE DEVELOPMENT 22 275 2.765e-05 0.001671
78 EMBRYO DEVELOPMENT 49 894 2.987e-05 0.001773
79 REGULATION OF SECRETION 41 699 3.01e-05 0.001773
80 REGULATION OF ERK1 AND ERK2 CASCADE 20 238 3.164e-05 0.00184
81 CELL CELL ADHESION 37 608 3.402e-05 0.001949
82 REGULATION OF CELL PROLIFERATION 72 1496 3.434e-05 0.001949
83 ACTIN FILAMENT BASED PROCESS 30 450 3.638e-05 0.00204
84 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 21 262 4.068e-05 0.002254
85 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 83 1805 4.2e-05 0.002299
86 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 54 1036 4.582e-05 0.002433
87 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 54 1036 4.582e-05 0.002433
88 REGULATION OF PHOSPHORUS METABOLIC PROCESS 76 1618 4.601e-05 0.002433
89 EYE DEVELOPMENT 24 326 4.67e-05 0.002441
90 POSITIVE REGULATION OF TRANSPORT 50 936 4.781e-05 0.002472
91 POSITIVE REGULATION OF GENE EXPRESSION 80 1733 5.153e-05 0.002635
92 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 29 437 5.308e-05 0.002682
93 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 15 153 5.361e-05 0.002682
94 GLIAL CELL DIFFERENTIATION 14 136 5.539e-05 0.002742
95 TAXIS 30 464 6.373e-05 0.003122
96 DEVELOPMENTAL GROWTH 24 333 6.527e-05 0.003164
97 ARTERY DEVELOPMENT 10 75 7.331e-05 0.003517
98 REGULATION OF FAT CELL DIFFERENTIATION 12 106 7.421e-05 0.003523
99 CARDIAC MUSCLE TISSUE DEVELOPMENT 14 140 7.611e-05 0.003577
100 NEGATIVE REGULATION OF CELL DIFFERENTIATION 36 609 7.841e-05 0.003649
101 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 81 1784 8.063e-05 0.003715
102 POSITIVE REGULATION OF CELL DEVELOPMENT 30 472 8.665e-05 0.003953
103 MUSCLE ORGAN DEVELOPMENT 21 277 9.066e-05 0.004096
104 NEURON MIGRATION 12 110 0.0001065 0.004765
105 SKELETAL SYSTEM MORPHOGENESIS 17 201 0.0001126 0.00499
106 NEGATIVE REGULATION OF CELL DEVELOPMENT 22 303 0.0001169 0.005056
107 POSITIVE REGULATION OF NEUTROPHIL MIGRATION 6 27 0.0001174 0.005056
108 MUSCLE SYSTEM PROCESS 21 282 0.0001167 0.005056
109 REGULATION OF EPITHELIAL CELL PROLIFERATION 21 285 0.0001352 0.005773
110 CELL JUNCTION ORGANIZATION 16 185 0.0001371 0.005799
111 POSITIVE REGULATION OF LEUKOCYTE CHEMOTAXIS 10 81 0.0001416 0.005938
112 NEURON PROJECTION GUIDANCE 17 205 0.0001431 0.005945
113 REGULATION OF LEUKOCYTE MIGRATION 14 149 0.0001488 0.006125
114 KIDNEY MORPHOGENESIS 10 82 0.0001571 0.006412
115 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 8 53 0.0001593 0.006447
116 CELL FATE COMMITMENT 18 227 0.0001622 0.006492
117 NEPHRON DEVELOPMENT 12 115 0.0001632 0.006492
118 MORPHOGENESIS OF AN EPITHELIUM 26 400 0.0001777 0.007007
119 POSITIVE REGULATION OF MAPK CASCADE 29 470 0.0001878 0.007181
120 REGULATION OF HOMEOSTATIC PROCESS 28 447 0.0001883 0.007181
121 MESENCHYMAL CELL DIFFERENTIATION 13 134 0.0001848 0.007181
122 STEM CELL DIFFERENTIATION 16 190 0.0001866 0.007181
123 POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE 15 172 0.0002006 0.00759
124 CARDIAC SEPTUM DEVELOPMENT 10 85 0.0002122 0.007963
125 HEART MORPHOGENESIS 17 212 0.0002141 0.007968
126 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 21 296 0.0002278 0.008411
127 POSITIVE REGULATION OF RESPONSE TO STIMULUS 84 1929 0.0002375 0.008566
128 CONNECTIVE TISSUE DEVELOPMENT 16 194 0.0002368 0.008566
129 OUTFLOW TRACT MORPHOGENESIS 8 56 0.0002362 0.008566
130 GLIOGENESIS 15 175 0.0002424 0.008675
131 EAR DEVELOPMENT 16 195 0.0002511 0.008917
132 CIRCULATORY SYSTEM PROCESS 24 366 0.0002739 0.009581
133 ION HOMEOSTASIS 33 576 0.0002734 0.009581
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION COACTIVATOR ACTIVITY 8 36 8.484e-06 0.007882
2 ACTIN BINDING 28 393 2.028e-05 0.009422
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 71 1151 4.138e-09 2.417e-06
2 INTRINSIC COMPONENT OF PLASMA MEMBRANE 89 1649 2.492e-08 7.278e-06
3 CELL PROJECTION 92 1786 1.235e-07 2.404e-05
4 PROTEINACEOUS EXTRACELLULAR MATRIX 29 356 1.058e-06 0.0001544
5 NEURON PART 67 1265 3.105e-06 0.000264
6 NEURON PROJECTION 54 942 3.194e-06 0.000264
7 CELL PROJECTION PART 54 946 3.617e-06 0.000264
8 MEMBRANE REGION 62 1134 2.723e-06 0.000264
9 PLASMA MEMBRANE REGION 52 929 9.541e-06 0.0006191
10 EXTRACELLULAR MATRIX COMPONENT 14 125 2.152e-05 0.001257
11 ANCHORING JUNCTION 32 489 2.897e-05 0.001538
12 EXTRACELLULAR MATRIX 29 426 3.355e-05 0.001633
13 BRUSH BORDER 12 102 5.073e-05 0.002279
14 SARCOLEMMA 13 125 9.123e-05 0.003806
15 CELL SUBSTRATE JUNCTION 26 398 0.0001642 0.006296
16 CELL SURFACE 41 757 0.0001725 0.006296
17 APICAL PART OF CELL 24 361 0.0002236 0.00768
18 CLUSTER OF ACTIN BASED CELL PROJECTIONS 13 139 0.0002658 0.008624
19 COLLAGEN TRIMER 10 88 0.0002827 0.008689

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 13 199 0.00676 0.1757
2 cGMP_PKG_signaling_pathway_hsa04022 11 163 0.00969 0.1757
3 Cell_adhesion_molecules_.CAMs._hsa04514 10 145 0.01155 0.1757
4 Gap_junction_hsa04540 7 88 0.01589 0.1757
5 Phospholipase_D_signaling_pathway_hsa04072 9 146 0.03069 0.1757
6 MAPK_signaling_pathway_hsa04010 15 295 0.03139 0.1757
7 PI3K_Akt_signaling_pathway_hsa04151 17 352 0.03514 0.1757
8 Phagosome_hsa04145 9 152 0.03823 0.1757
9 TGF_beta_signaling_pathway_hsa04350 6 84 0.03911 0.1757
10 Hippo_signaling_pathway_hsa04390 9 154 0.041 0.1757
11 ABC_transporters_hsa02010 4 45 0.04423 0.1757
12 Rap1_signaling_pathway_hsa04015 11 206 0.04468 0.1757
13 Ras_signaling_pathway_hsa04014 12 232 0.04543 0.1757
14 Regulation_of_actin_cytoskeleton_hsa04810 11 208 0.04731 0.1757
15 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.05401 0.1872
16 Calcium_signaling_pathway_hsa04020 9 182 0.09437 0.298
17 ECM_receptor_interaction_hsa04512 5 82 0.09742 0.298
18 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 7 139 0.1214 0.3506
19 HIF_1_signaling_pathway_hsa04066 5 100 0.1775 0.4858
20 Apelin_signaling_pathway_hsa04371 6 137 0.224 0.5756
21 cAMP_signaling_pathway_hsa04024 8 198 0.238 0.5756
22 Tight_junction_hsa04530 7 170 0.2435 0.5756
23 Cytokine_cytokine_receptor_interaction_hsa04060 10 270 0.2847 0.6307
24 AMPK_signaling_pathway_hsa04152 5 121 0.2921 0.6307
25 Oocyte_meiosis_hsa04114 5 124 0.3095 0.6307
26 Neuroactive_ligand_receptor_interaction_hsa04080 10 278 0.3153 0.6307
27 FoxO_signaling_pathway_hsa04068 5 132 0.3566 0.6729
28 Adherens_junction_hsa04520 3 72 0.3623 0.6729
29 Hedgehog_signaling_pathway_hsa04340 2 47 0.4098 0.7348
30 Wnt_signaling_pathway_hsa04310 5 146 0.4392 0.7391
31 Endocytosis_hsa04144 8 244 0.4406 0.7391
32 Mitophagy_animal_hsa04137 2 65 0.5801 0.9427
33 p53_signaling_pathway_hsa04115 2 68 0.6048 0.953
34 Necroptosis_hsa04217 4 164 0.7229 1
35 Apoptosis_hsa04210 3 138 0.7824 1
36 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.7978 1
37 mTOR_signaling_pathway_hsa04150 3 151 0.8308 1
38 Cellular_senescence_hsa04218 3 160 0.8587 1
39 Jak_STAT_signaling_pathway_hsa04630 3 162 0.8643 1
40 Sphingolipid_signaling_pathway_hsa04071 2 118 0.8699 1
41 Lysosome_hsa04142 2 123 0.8845 1
42 Autophagy_animal_hsa04140 2 128 0.8976 1

Quest ID: 35b91d0124dd915afb498698f6e35255