Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-10a-5p TMOD1 1.15 0.00372 -2.51 0 miRNATAP -0.15 3.0E-5 NA
2 hsa-miR-10b-5p TMOD1 -0.16 0.55501 -2.51 0 miRNATAP -0.11 0.03912 NA
3 hsa-miR-1266-5p TMOD1 1.38 0.00088 -2.51 0 MirTarget -0.17 0 NA
4 hsa-miR-1301-3p TMOD1 2.55 0 -2.51 0 MirTarget -0.35 0 NA
5 hsa-miR-182-5p TMOD1 3.54 0 -2.51 0 miRNATAP -0.32 0 NA
6 hsa-miR-186-5p TMOD1 1.47 0 -2.51 0 miRNATAP -0.5 0 NA
7 hsa-miR-219a-1-3p TMOD1 1.15 0.00049 -2.51 0 MirTarget -0.3 0 NA
8 hsa-miR-23a-3p TMOD1 1 0 -2.51 0 MirTarget; miRNATAP -0.68 0 NA
9 hsa-miR-3065-5p TMOD1 2.75 0 -2.51 0 MirTarget; mirMAP -0.16 1.0E-5 NA
10 hsa-miR-30e-3p TMOD1 -0.22 0.23538 -2.51 0 mirMAP -0.18 0.01975 NA
11 hsa-miR-320a TMOD1 0.44 0.03902 -2.51 0 miRanda -0.3 1.0E-5 NA
12 hsa-miR-320b TMOD1 1.56 0 -2.51 0 miRanda -0.38 0 NA
13 hsa-miR-335-3p TMOD1 3.09 0 -2.51 0 mirMAP -0.22 0 NA
14 hsa-miR-421 TMOD1 1.18 1.0E-5 -2.51 0 miRanda -0.19 0.00054 NA
15 hsa-miR-429 TMOD1 4.49 0 -2.51 0 miRanda; miRNATAP -0.22 0 NA
16 hsa-miR-486-5p TMOD1 -0.19 0.60738 -2.51 0 miRanda; miRNATAP -0.11 0.00231 NA
17 hsa-miR-582-3p TMOD1 0.01 0.97713 -2.51 0 miRNATAP -0.13 0.004 NA
18 hsa-miR-582-5p TMOD1 0.61 0.03299 -2.51 0 mirMAP; miRNATAP -0.21 2.0E-5 NA
19 hsa-miR-744-3p TMOD1 2.75 0 -2.51 0 MirTarget -0.32 0 NA
20 hsa-miR-96-5p TMOD1 4.89 0 -2.51 0 miRNATAP -0.3 0 NA
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 CYTOSKELETAL PROTEIN BINDING 11 819 1.635e-07 0.0001519
2 ACTIN BINDING 7 393 6.639e-06 0.003084
3 CADHERIN BINDING 3 28 1.849e-05 0.005727
NumGOOverlapSizeP ValueAdj. P Value
1 ACTIN CYTOSKELETON 8 444 1.215e-06 0.0004529
2 CELL CORTEX PART 5 119 2.565e-06 0.0004529
3 LATERAL PLASMA MEMBRANE 4 50 2.148e-06 0.0004529
4 CELL LEADING EDGE 7 350 3.102e-06 0.0004529
5 CELL CORTEX 6 238 4.552e-06 0.0005316
6 CYTOPLASMIC REGION 6 287 1.325e-05 0.00129
7 ORGANELLE SUBCOMPARTMENT 6 311 2.087e-05 0.001741
8 APICAL JUNCTION COMPLEX 4 128 8.976e-05 0.00621
9 EXTRINSIC COMPONENT OF MEMBRANE 5 252 9.57e-05 0.00621
10 EXTRINSIC COMPONENT OF PLASMA MEMBRANE 4 136 0.0001135 0.006629
11 CYTOSKELETON 12 1967 0.0001407 0.007471
12 CYTOSKELETAL PART 10 1436 0.0002044 0.009948

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cellular_senescence_hsa04218 3 160 0.003198 0.136
2 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.006641 0.136
3 Adherens_junction_hsa04520 2 72 0.007846 0.136
4 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.01443 0.1771
5 Lysosome_hsa04142 2 123 0.02171 0.1771
6 Apelin_signaling_pathway_hsa04371 2 137 0.02653 0.1771
7 Apoptosis_hsa04210 2 138 0.02689 0.1771
8 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.02725 0.1771
9 Hippo_signaling_pathway_hsa04390 2 154 0.0329 0.1898
10 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.0365 0.1898
11 Calcium_signaling_pathway_hsa04020 2 182 0.04455 0.2106
12 cAMP_signaling_pathway_hsa04024 2 198 0.05179 0.2223
13 Rap1_signaling_pathway_hsa04015 2 206 0.05557 0.2223

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 MIR143HG hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-429;hsa-miR-486-5p;hsa-miR-582-3p;hsa-miR-582-5p;hsa-miR-744-3p 18 TMOD1 Sponge network -4.237 0 -2.508 0 0.566
2 C20orf166-AS1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-429;hsa-miR-486-5p;hsa-miR-582-5p 14 TMOD1 Sponge network -6.333 0 -2.508 0 0.529
3 RP11-887P2.5 hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-421;hsa-miR-486-5p;hsa-miR-744-3p 11 TMOD1 Sponge network -6.751 0 -2.508 0 0.523
4 RP11-166D19.1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-421;hsa-miR-429;hsa-miR-96-5p 16 TMOD1 Sponge network -3.855 0 -2.508 0 0.513
5 ADAMTS9-AS1 hsa-miR-10a-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-421;hsa-miR-429;hsa-miR-582-5p;hsa-miR-744-3p;hsa-miR-96-5p 17 TMOD1 Sponge network -7.614 0 -2.508 0 0.503
6 FENDRR hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-421;hsa-miR-486-5p;hsa-miR-744-3p;hsa-miR-96-5p 14 TMOD1 Sponge network -4.793 0 -2.508 0 0.5
7 RP11-175K6.1 hsa-miR-10a-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-421;hsa-miR-744-3p;hsa-miR-96-5p 13 TMOD1 Sponge network -2.386 0 -2.508 0 0.478
8 RP11-389G6.3 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b 11 TMOD1 Sponge network -7.573 0 -2.508 0 0.459
9 LINC00702 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-421;hsa-miR-582-3p;hsa-miR-582-5p;hsa-miR-744-3p;hsa-miR-96-5p 18 TMOD1 Sponge network -2.704 0 -2.508 0 0.445
10 HAND2-AS1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-421;hsa-miR-429;hsa-miR-486-5p;hsa-miR-582-3p;hsa-miR-582-5p;hsa-miR-744-3p 18 TMOD1 Sponge network -5.605 0 -2.508 0 0.443
11 GAS6-AS2 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-335-3p;hsa-miR-421;hsa-miR-429 12 TMOD1 Sponge network -2.655 0 -2.508 0 0.439
12 RP11-753H16.3 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-744-3p 11 TMOD1 Sponge network -5.702 0 -2.508 0 0.436
13 RP11-20J15.3 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-582-5p 10 TMOD1 Sponge network -5.104 8.0E-5 -2.508 0 0.426
14 RP11-805I24.3 hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-421;hsa-miR-429;hsa-miR-744-3p 12 TMOD1 Sponge network -5.815 0 -2.508 0 0.425
15 USP3-AS1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-421;hsa-miR-486-5p;hsa-miR-744-3p 13 TMOD1 Sponge network -1.454 0 -2.508 0 0.403
16 RP11-531A24.5 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p 10 TMOD1 Sponge network -1.752 0 -2.508 0 0.392
17 C4A-AS1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-486-5p;hsa-miR-744-3p;hsa-miR-96-5p 12 TMOD1 Sponge network -1.76 0.00265 -2.508 0 0.391
18 GATA6-AS1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-582-3p 10 TMOD1 Sponge network -3.855 0 -2.508 0 0.39
19 AF131217.1 hsa-miR-10a-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-421;hsa-miR-744-3p;hsa-miR-96-5p 13 TMOD1 Sponge network -5.31 0 -2.508 0 0.389
20 TP73-AS1 hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-421;hsa-miR-429;hsa-miR-96-5p 12 TMOD1 Sponge network -1.97 0 -2.508 0 0.387
21 RP11-359B12.2 hsa-miR-10a-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-429;hsa-miR-582-5p;hsa-miR-744-3p;hsa-miR-96-5p 10 TMOD1 Sponge network -1.336 0 -2.508 0 0.377
22 BVES-AS1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-429;hsa-miR-744-3p 12 TMOD1 Sponge network -4.161 1.0E-5 -2.508 0 0.374
23 MAGI2-AS3 hsa-miR-10a-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-421;hsa-miR-429;hsa-miR-582-3p;hsa-miR-582-5p 16 TMOD1 Sponge network -2.414 0 -2.508 0 0.366
24 ACTA2-AS1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-335-3p;hsa-miR-582-3p;hsa-miR-744-3p;hsa-miR-96-5p 13 TMOD1 Sponge network -3.838 0 -2.508 0 0.347
25 RP11-456K23.1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-429;hsa-miR-744-3p 11 TMOD1 Sponge network -1.962 1.0E-5 -2.508 0 0.34
26 BZRAP1-AS1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-335-3p;hsa-miR-582-3p;hsa-miR-744-3p 12 TMOD1 Sponge network -2.343 0 -2.508 0 0.326
27 PDZRN3-AS1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-320a;hsa-miR-320b 11 TMOD1 Sponge network -5.049 1.0E-5 -2.508 0 0.321
28 RP11-554A11.4 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-23a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-421 10 TMOD1 Sponge network -3.989 0 -2.508 0 0.321
29 MEG3 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-421;hsa-miR-429;hsa-miR-582-3p;hsa-miR-744-3p;hsa-miR-96-5p 16 TMOD1 Sponge network -2.367 0 -2.508 0 0.314
30 NR2F1-AS1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-421;hsa-miR-429;hsa-miR-582-5p;hsa-miR-744-3p 15 TMOD1 Sponge network -1.881 0 -2.508 0 0.306
31 RP11-356J5.12 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p 10 TMOD1 Sponge network -2.015 0 -2.508 0 0.296
32 RASSF8-AS1 hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-429;hsa-miR-582-5p;hsa-miR-744-3p 10 TMOD1 Sponge network -0.877 0.00508 -2.508 0 0.265
33 DNM3OS hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-3065-5p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-429;hsa-miR-744-3p;hsa-miR-96-5p 15 TMOD1 Sponge network -2.298 1.0E-5 -2.508 0 0.259
34 AC093627.10 hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-23a-3p;hsa-miR-30e-3p;hsa-miR-421;hsa-miR-429;hsa-miR-744-3p 10 TMOD1 Sponge network -2.338 8.0E-5 -2.508 0 0.257
35 VIM-AS1 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-3065-5p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-421 12 TMOD1 Sponge network -1.424 0.00627 -2.508 0 0.255
36 RP11-35G9.5 hsa-miR-10a-5p;hsa-miR-10b-5p;hsa-miR-1266-5p;hsa-miR-1301-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-219a-1-3p;hsa-miR-3065-5p;hsa-miR-421;hsa-miR-744-3p;hsa-miR-96-5p 11 TMOD1 Sponge network -0.537 0.0574 -2.508 0 0.253

Quest ID: 36f404fe3bc07825253ec3cb17ba9530