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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106a-5p ABCA1 2.49 0 -0.71 0.00276 MirTarget; miRNATAP -0.12 7.0E-5 NA
2 hsa-miR-106a-5p ABCD2 2.49 0 -3.08 0 MirTarget -0.35 0 NA
3 hsa-miR-106a-5p ADAM19 2.49 0 -1.06 0.01895 mirMAP -0.33 0 NA
4 hsa-miR-106a-5p ADARB1 2.49 0 -1.93 0 MirTarget -0.28 0 NA
5 hsa-miR-106a-5p ADCY9 2.49 0 -1.5 0 mirMAP -0.21 0 NA
6 hsa-miR-106a-5p AHNAK 2.49 0 -1.66 0 miRNATAP -0.31 0 NA
7 hsa-miR-106a-5p AKAP13 2.49 0 -1.15 0 MirTarget; mirMAP; miRNATAP -0.17 0 NA
8 hsa-miR-106a-5p AKT3 2.49 0 -1.94 0 miRNATAP -0.24 0 NA
9 hsa-miR-106a-5p ALPK3 2.49 0 -1.02 0.00049 mirMAP -0.13 0.00095 NA
10 hsa-miR-106a-5p ANK2 2.49 0 -4.32 0 MirTarget; miRNATAP -0.38 0 NA
11 hsa-miR-106a-5p ANKH 2.49 0 -0.38 0.21654 MirTarget -0.17 4.0E-5 NA
12 hsa-miR-106a-5p ANKRD29 2.49 0 -3.47 0 MirTarget -0.51 0 NA
13 hsa-miR-106a-5p ANKRD50 2.49 0 -0.88 0.00174 MirTarget; miRNATAP -0.11 0.0047 NA
14 hsa-miR-106a-5p ANXA11 2.49 0 -0.43 0.01849 mirMAP -0.12 0 NA
15 hsa-miR-106a-5p APBB2 2.49 0 -0.59 0.0014 MirTarget; miRNATAP -0.15 0 NA
16 hsa-miR-106a-5p APP 2.49 0 -0.4 0.04288 miRNAWalker2 validate; miRTarBase; miRNATAP -0.14 0 NA
17 hsa-miR-106a-5p ARHGAP1 2.49 0 -0.88 0 MirTarget; miRNATAP -0.17 0 NA
18 hsa-miR-106a-5p ARHGAP24 2.49 0 -2.02 0 MirTarget -0.33 0 NA
19 hsa-miR-106a-5p ARHGEF3 2.49 0 -0.76 0 MirTarget; miRNATAP -0.12 0 NA
20 hsa-miR-106a-5p ARL10 2.49 0 -1.12 0.00198 mirMAP -0.2 2.0E-5 NA
21 hsa-miR-106a-5p ARL4C 2.49 0 -0.28 0.33535 MirTarget; miRNATAP -0.22 0 NA
22 hsa-miR-106a-5p ARL9 2.49 0 -0.12 0.79825 miRNAWalker2 validate -0.13 0.03455 NA
23 hsa-miR-106a-5p ARSB 2.49 0 -0.58 0.00052 mirMAP -0.15 0 NA
24 hsa-miR-106a-5p ASPA 2.49 0 -4.76 0 mirMAP -0.26 0.001 NA
25 hsa-miR-106a-5p ATE1 2.49 0 -1.09 3.0E-5 MirTarget -0.11 0.00166 NA
26 hsa-miR-106a-5p ATP1A2 2.49 0 -6.96 0 MirTarget -0.8 0 NA
27 hsa-miR-106a-5p ATXN1 2.49 0 -1.51 0 miRNATAP -0.28 0 NA
28 hsa-miR-106a-5p B3GALT2 2.49 0 -3.85 0 MirTarget -0.28 0 NA
29 hsa-miR-106a-5p BCL2L2 2.49 0 -1.27 0 miRNATAP -0.1 1.0E-5 NA
30 hsa-miR-106a-5p BMP2 2.49 0 -1.46 0.00276 miRNATAP -0.14 0.03534 NA
31 hsa-miR-106a-5p BMP7 2.49 0 -1.78 0.02876 mirMAP -0.21 0.04978 NA
32 hsa-miR-106a-5p BMPR2 2.49 0 -0.59 4.0E-5 MirTarget; miRNATAP -0.13 0 NA
33 hsa-miR-106a-5p BNC2 2.49 0 -2.95 0 miRNATAP -0.6 0 NA
34 hsa-miR-106a-5p C14orf28 2.49 0 -0.89 0 miRNATAP -0.11 0 NA
35 hsa-miR-106a-5p C3orf70 2.49 0 -2.6 0 miRNATAP -0.12 0.02806 NA
36 hsa-miR-106a-5p CALD1 2.49 0 -2.47 0 miRNATAP -0.49 0 NA
37 hsa-miR-106a-5p CBX7 2.49 0 -2.55 0 mirMAP -0.22 0 NA
38 hsa-miR-106a-5p CCBE1 2.49 0 -1.07 0.09592 mirMAP -0.19 0.02573 NA
39 hsa-miR-106a-5p CCND1 2.49 0 0.08 0.84033 MirTarget; miRNATAP -0.28 0 NA
40 hsa-miR-106a-5p CCND2 2.49 0 -2.43 0 miRNATAP -0.46 0 NA
41 hsa-miR-106a-5p CD69 2.49 0 -2.49 0 miRNATAP -0.35 0 NA
42 hsa-miR-106a-5p CDK6 2.49 0 -0.77 0.06479 mirMAP -0.24 2.0E-5 NA
43 hsa-miR-106a-5p CDKN1A 2.49 0 -1.29 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.13 0.00055 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a
44 hsa-miR-106a-5p CELF2 2.49 0 -3.05 0 miRNATAP -0.48 0 NA
45 hsa-miR-106a-5p CERCAM 2.49 0 0.21 0.50968 MirTarget -0.14 0.00074 NA
46 hsa-miR-106a-5p CERK 2.49 0 -1.14 9.0E-5 mirMAP -0.15 0.00017 NA
47 hsa-miR-106a-5p CFL2 2.49 0 -2.62 0 MirTarget; miRNATAP -0.29 0 NA
48 hsa-miR-106a-5p CHD5 2.49 0 -3.46 0 MirTarget; miRNATAP -0.18 0.00312 NA
49 hsa-miR-106a-5p CHD9 2.49 0 -0.8 1.0E-5 MirTarget; miRNATAP -0.11 0 NA
50 hsa-miR-106a-5p CLDN16 2.49 0 0.26 0.60929 mirMAP -0.14 0.04546 NA
51 hsa-miR-106a-5p CLIP4 2.49 0 -1.61 0 MirTarget -0.3 0 NA
52 hsa-miR-106a-5p CNR2 2.49 0 -2.05 6.0E-5 mirMAP -0.32 0 NA
53 hsa-miR-106a-5p COL1A1 2.49 0 -0.11 0.82007 mirMAP -0.44 0 NA
54 hsa-miR-106a-5p COL8A2 2.49 0 -1.27 0.00295 mirMAP -0.44 0 NA
55 hsa-miR-106a-5p CORO2B 2.49 0 -2.03 0 MirTarget; miRNATAP -0.2 0.0007 NA
56 hsa-miR-106a-5p CPEB3 2.49 0 -1.3 0 miRNATAP -0.12 0 NA
57 hsa-miR-106a-5p CPEB4 2.49 0 -1.56 0 mirMAP -0.17 0 NA
58 hsa-miR-106a-5p CPT1A 2.49 0 -0.83 0.00093 mirMAP -0.1 0.00197 NA
59 hsa-miR-106a-5p CREB5 2.49 0 -2.28 0 MirTarget; miRNATAP -0.28 0 NA
60 hsa-miR-106a-5p CRIM1 2.49 0 -0.45 0.0534 MirTarget; miRNATAP -0.11 0.00044 NA
61 hsa-miR-106a-5p CRY2 2.49 0 -1.68 0 MirTarget; miRNATAP -0.14 0 NA
62 hsa-miR-106a-5p CRYBG3 2.49 0 -1.11 5.0E-5 MirTarget; miRNATAP -0.22 0 NA
63 hsa-miR-106a-5p CSF1 2.49 0 -1.3 0.00033 miRNATAP -0.29 0 NA
64 hsa-miR-106a-5p CSGALNACT1 2.49 0 -2.42 0 MirTarget -0.24 0 NA
65 hsa-miR-106a-5p CTSK 2.49 0 -1.41 0.00081 MirTarget -0.46 0 NA
66 hsa-miR-106a-5p CXorf36 2.49 0 -1.52 0 mirMAP -0.18 0 NA
67 hsa-miR-106a-5p CYBRD1 2.49 0 -2.55 0 MirTarget -0.41 0 NA
68 hsa-miR-106a-5p CYP19A1 2.49 0 -1.81 3.0E-5 miRNAWalker2 validate -0.27 0 NA
69 hsa-miR-106a-5p DAB2 2.49 0 -0.69 0.03265 MirTarget; miRNATAP -0.13 0.00261 NA
70 hsa-miR-106a-5p DCBLD2 2.49 0 -0.13 0.73597 miRNAWalker2 validate; MirTarget; miRNATAP -0.11 0.03077 NA
71 hsa-miR-106a-5p DIXDC1 2.49 0 -3.01 0 mirMAP -0.39 0 NA
72 hsa-miR-106a-5p DLG2 2.49 0 -3.8 0 mirMAP -0.37 0 NA
73 hsa-miR-106a-5p DMD 2.49 0 -3.69 0 mirMAP -0.45 0 NA
74 hsa-miR-106a-5p DNAJB9 2.49 0 -0.44 0.00239 miRNATAP -0.11 0 NA
75 hsa-miR-106a-5p DPYD 2.49 0 -1.71 0.00028 MirTarget -0.47 0 NA
76 hsa-miR-106a-5p DPYSL2 2.49 0 -1.76 0 MirTarget; miRNATAP -0.24 0 NA
77 hsa-miR-106a-5p DST 2.49 0 -1.12 9.0E-5 mirMAP -0.2 0 NA
78 hsa-miR-106a-5p DUSP8 2.49 0 -2.17 0 MirTarget; miRNATAP -0.17 0.00013 NA
79 hsa-miR-106a-5p EDA2R 2.49 0 -1.5 0.00021 MirTarget -0.24 1.0E-5 NA
80 hsa-miR-106a-5p EGR2 2.49 0 -2.81 0 MirTarget; miRNATAP -0.35 0 NA
81 hsa-miR-106a-5p EIF5A2 2.49 0 -1.12 0.00497 miRNATAP -0.28 0 NA
82 hsa-miR-106a-5p ELK3 2.49 0 -0.31 0.25641 MirTarget; miRNATAP -0.18 0 NA
83 hsa-miR-106a-5p ENPP1 2.49 0 -2.1 0 mirMAP -0.34 0 NA
84 hsa-miR-106a-5p ENTPD1 2.49 0 -1.12 0 mirMAP -0.22 0 NA
85 hsa-miR-106a-5p EPAS1 2.49 0 -0.53 0.02805 miRNATAP -0.18 0 NA
86 hsa-miR-106a-5p EPHA7 2.49 0 -4.2 0 miRNATAP -0.27 0.00123 NA
87 hsa-miR-106a-5p ETV1 2.49 0 -0.69 0.03823 MirTarget; miRNATAP -0.26 0 NA
88 hsa-miR-106a-5p F3 2.49 0 -1.93 0.00015 MirTarget; miRNATAP -0.38 0 NA
89 hsa-miR-106a-5p FAM46C 2.49 0 -1.66 0 MirTarget; miRNATAP -0.15 0.00033 NA
90 hsa-miR-106a-5p FAS 2.49 0 -0.89 0.00676 miRNAWalker2 validate; miRTarBase -0.29 0 22431000; 27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway
91 hsa-miR-106a-5p FAT2 2.49 0 0.77 0.30922 MirTarget; miRNATAP -0.29 0.00416 NA
92 hsa-miR-106a-5p FAT4 2.49 0 -2.57 0 MirTarget; miRNATAP -0.42 0 NA
93 hsa-miR-106a-5p FBXO31 2.49 0 -0.84 0 MirTarget -0.12 0 NA
94 hsa-miR-106a-5p FGD5 2.49 0 -1.17 0.00053 MirTarget; miRNATAP -0.21 0 NA
95 hsa-miR-106a-5p FGFR1 2.49 0 -2.88 0 mirMAP -0.38 0 NA
96 hsa-miR-106a-5p FGL2 2.49 0 -3.72 0 MirTarget -0.5 0 NA
97 hsa-miR-106a-5p FHL2 2.49 0 -0.45 0.13074 mirMAP -0.16 7.0E-5 NA
98 hsa-miR-106a-5p FIBIN 2.49 0 -1.93 0.00102 MirTarget -0.62 0 NA
99 hsa-miR-106a-5p FKBP5 2.49 0 -1.54 4.0E-5 mirMAP -0.16 0.00182 NA
100 hsa-miR-106a-5p FMN1 2.49 0 -0.37 0.4819 mirMAP -0.16 0.02159 NA
101 hsa-miR-106a-5p FNDC3A 2.49 0 -0.54 0.00477 MirTarget; miRNATAP -0.12 0 NA
102 hsa-miR-106a-5p FOXN3 2.49 0 -1.44 0 miRNATAP -0.11 1.0E-5 NA
103 hsa-miR-106a-5p FRMD6 2.49 0 -0.93 0.00183 MirTarget; miRNATAP -0.26 0 NA
104 hsa-miR-106a-5p FYCO1 2.49 0 -1.62 0 MirTarget -0.19 0 NA
105 hsa-miR-106a-5p FYN 2.49 0 -1.47 0 miRNATAP -0.14 0.00023 NA
106 hsa-miR-106a-5p GAS7 2.49 0 -2.67 0 mirMAP -0.49 0 NA
107 hsa-miR-106a-5p GBP4 2.49 0 0.37 0.3093 mirMAP -0.1 0.03283 NA
108 hsa-miR-106a-5p GFRA1 2.49 0 -5 0 mirMAP -0.45 0 NA
109 hsa-miR-106a-5p GLIS3 2.49 0 -0.79 0.02459 miRNATAP -0.2 1.0E-5 NA
110 hsa-miR-106a-5p GM2A 2.49 0 0.07 0.72789 mirMAP -0.12 3.0E-5 NA
111 hsa-miR-106a-5p GPRC5A 2.49 0 -1.04 0.01909 mirMAP -0.2 0.00093 NA
112 hsa-miR-106a-5p GREM2 2.49 0 -4.99 0 mirMAP -0.44 0 NA
113 hsa-miR-106a-5p GRM6 2.49 0 -0.78 0.14738 mirMAP -0.15 0.0379 NA
114 hsa-miR-106a-5p HABP4 2.49 0 -1.4 0 MirTarget; miRNATAP -0.13 1.0E-5 NA
115 hsa-miR-106a-5p HAS2 2.49 0 -1.45 0.00631 MirTarget -0.26 0.00024 NA
116 hsa-miR-106a-5p HDAC4 2.49 0 -1.8 0 mirMAP; miRNATAP -0.14 0 NA
117 hsa-miR-106a-5p HEG1 2.49 0 -0.95 0.00135 miRNATAP -0.31 0 NA
118 hsa-miR-106a-5p HES2 2.49 0 3.15 1.0E-5 mirMAP -0.23 0.02002 NA
119 hsa-miR-106a-5p HFE 2.49 0 0.04 0.89191 mirMAP -0.15 0.00043 NA
120 hsa-miR-106a-5p HIPK3 2.49 0 -1.75 0 miRNAWalker2 validate; miRTarBase -0.16 0.00101 NA
121 hsa-miR-106a-5p HLF 2.49 0 -5.48 0 MirTarget; miRNATAP -0.49 0 NA
122 hsa-miR-106a-5p IGSF10 2.49 0 -5.3 0 MirTarget -0.35 0.0001 NA
123 hsa-miR-106a-5p IL10 2.49 0 -0.99 0.03081 miRNAWalker2 validate -0.29 0 NA
124 hsa-miR-106a-5p IL1RAP 2.49 0 0.69 0.05618 MirTarget -0.18 0.00011 NA
125 hsa-miR-106a-5p IL6R 2.49 0 -1.87 0 mirMAP -0.19 0.0004 NA
126 hsa-miR-106a-5p ISM1 2.49 0 -0.18 0.67268 miRNATAP -0.28 0 NA
127 hsa-miR-106a-5p ITPRIPL2 2.49 0 -0.05 0.79208 MirTarget; miRNATAP -0.12 0 NA
128 hsa-miR-106a-5p JAK1 2.49 0 -0.65 0 MirTarget -0.13 0 NA
129 hsa-miR-106a-5p JAM2 2.49 0 -3.24 0 miRNATAP -0.44 0 NA
130 hsa-miR-106a-5p JAZF1 2.49 0 -1.92 0 MirTarget; miRNATAP -0.3 0 NA
131 hsa-miR-106a-5p KATNAL1 2.49 0 -1.58 1.0E-5 MirTarget -0.21 1.0E-5 NA
132 hsa-miR-106a-5p KBTBD8 2.49 0 -1.48 0 MirTarget -0.17 8.0E-5 NA
133 hsa-miR-106a-5p KCND3 2.49 0 -4.09 0 mirMAP -0.6 0 NA
134 hsa-miR-106a-5p KCNMA1 2.49 0 -3.78 0 miRNATAP -0.52 0 NA
135 hsa-miR-106a-5p KIAA0513 2.49 0 -1.87 0 MirTarget; miRNATAP -0.33 0 NA
136 hsa-miR-106a-5p KIAA0922 2.49 0 -1.16 0.00013 MirTarget -0.22 0 NA
137 hsa-miR-106a-5p KIF13A 2.49 0 -1.22 0 miRNATAP -0.15 0 NA
138 hsa-miR-106a-5p KIF26B 2.49 0 2.26 0 miRNATAP -0.19 0.0006 NA
139 hsa-miR-106a-5p KLF13 2.49 0 -1.16 1.0E-5 mirMAP -0.13 0.00043 NA
140 hsa-miR-106a-5p KLF9 2.49 0 -2.79 0 MirTarget; miRNATAP -0.37 0 NA
141 hsa-miR-106a-5p KLHL21 2.49 0 -1.04 0 mirMAP -0.14 0 NA
142 hsa-miR-106a-5p KPNA3 2.49 0 -0.57 0.00262 MirTarget; miRNATAP -0.14 0 NA
143 hsa-miR-106a-5p LAT2 2.49 0 -0.57 0.08955 mirMAP -0.21 0 NA
144 hsa-miR-106a-5p LDB3 2.49 0 -3.79 0 mirMAP -0.37 0 NA
145 hsa-miR-106a-5p LDLR 2.49 0 -1.42 7.0E-5 miRNATAP -0.15 0.00178 NA
146 hsa-miR-106a-5p LHX6 2.49 0 -0.89 0.00204 MirTarget; miRNATAP -0.12 0.00252 NA
147 hsa-miR-106a-5p LIF 2.49 0 -1.63 3.0E-5 miRNATAP -0.18 0.00054 NA
148 hsa-miR-106a-5p LIMA1 2.49 0 -0.1 0.68612 MirTarget; miRNATAP -0.15 0 NA
149 hsa-miR-106a-5p LMO3 2.49 0 -4.72 0 MirTarget; miRNATAP -0.42 0 NA
150 hsa-miR-106a-5p LPP 2.49 0 -2.04 0 mirMAP -0.26 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELL DIFFERENTIATION 58 1492 1.142e-11 4.375e-08
2 CELL DEVELOPMENT 56 1426 1.881e-11 4.375e-08
3 REGULATION OF CELL DEVELOPMENT 39 836 2.686e-10 3.124e-07
4 TISSUE DEVELOPMENT 56 1518 2.057e-10 3.124e-07
5 NEUROGENESIS 52 1402 8.562e-10 7.968e-07
6 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 57 1672 2.621e-09 2.033e-06
7 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 34 750 8.518e-09 5.662e-06
8 RESPONSE TO ENDOGENOUS STIMULUS 50 1450 2.08e-08 1.076e-05
9 REGULATION OF NEURON DIFFERENTIATION 28 554 1.979e-08 1.076e-05
10 POSITIVE REGULATION OF GENE EXPRESSION 56 1733 2.448e-08 1.139e-05
11 MUSCLE STRUCTURE DEVELOPMENT 24 432 3.678e-08 1.556e-05
12 ORGAN MORPHOGENESIS 35 841 4.313e-08 1.672e-05
13 POSITIVE REGULATION OF CELL DEVELOPMENT 25 472 4.797e-08 1.717e-05
14 ORGAN GROWTH 10 68 6.29e-08 2.044e-05
15 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 56 1784 6.59e-08 2.044e-05
16 SKELETAL SYSTEM DEVELOPMENT 24 455 9.71e-08 2.673e-05
17 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 56 1805 9.766e-08 2.673e-05
18 NEURON DIFFERENTIATION 35 874 1.101e-07 2.845e-05
19 MUSCLE TISSUE DEVELOPMENT 18 275 1.8e-07 3.653e-05
20 POSITIVE REGULATION OF NEURON DIFFERENTIATION 19 306 1.858e-07 3.653e-05
21 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 23 437 1.884e-07 3.653e-05
22 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 44 1275 1.632e-07 3.653e-05
23 REGULATION OF SYSTEM PROCESS 25 507 1.88e-07 3.653e-05
24 REGULATION OF CELLULAR COMPONENT MOVEMENT 32 771 1.819e-07 3.653e-05
25 CARDIOVASCULAR SYSTEM DEVELOPMENT 32 788 2.957e-07 5.292e-05
26 CIRCULATORY SYSTEM DEVELOPMENT 32 788 2.957e-07 5.292e-05
27 REGULATION OF OSSIFICATION 14 178 4.787e-07 8.25e-05
28 MUSCLE CELL DIFFERENTIATION 16 237 5.802e-07 9.309e-05
29 RESPONSE TO ALCOHOL 20 362 5.69e-07 9.309e-05
30 BONE DEVELOPMENT 13 156 6.38e-07 9.896e-05
31 EPITHELIUM DEVELOPMENT 35 945 6.95e-07 0.0001043
32 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 24 513 8.542e-07 0.0001242
33 MESONEPHROS DEVELOPMENT 10 90 9.273e-07 0.0001308
34 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 5 14 1.274e-06 0.0001703
35 CARDIAC MUSCLE TISSUE DEVELOPMENT 12 140 1.281e-06 0.0001703
36 NEGATIVE REGULATION OF CELL DIFFERENTIATION 26 609 1.637e-06 0.0002116
37 RESPONSE TO STEROID HORMONE 23 497 1.749e-06 0.0002142
38 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 35 983 1.708e-06 0.0002142
39 CARTILAGE DEVELOPMENT 12 147 2.148e-06 0.0002437
40 SKELETAL SYSTEM MORPHOGENESIS 14 201 2.055e-06 0.0002437
41 REGULATION OF CELL PROLIFERATION 46 1496 2.112e-06 0.0002437
42 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 53 1848 2.553e-06 0.0002828
43 KIDNEY EPITHELIUM DEVELOPMENT 11 125 2.75e-06 0.0002976
44 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 19 368 2.976e-06 0.0003147
45 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 18 337 3.396e-06 0.0003511
46 REGULATION OF NEURON PROJECTION DEVELOPMENT 20 408 3.576e-06 0.0003617
47 ENDOCHONDRAL BONE MORPHOGENESIS 7 45 4.245e-06 0.0004203
48 NEGATIVE REGULATION OF CELL PROLIFERATION 26 643 4.391e-06 0.0004256
49 NEURON DEVELOPMENT 27 687 4.825e-06 0.0004581
50 POSITIVE REGULATION OF LOCOMOTION 20 420 5.514e-06 0.0005131
51 OSSIFICATION 15 251 5.891e-06 0.0005194
52 NEGATIVE REGULATION OF PHOSPHORYLATION 20 422 5.916e-06 0.0005194
53 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 12 162 5.906e-06 0.0005194
54 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 23 541 7.127e-06 0.0005712
55 HEART DEVELOPMENT 21 466 7.489e-06 0.0005712
56 CONNECTIVE TISSUE DEVELOPMENT 13 194 7.27e-06 0.0005712
57 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 34 1004 7.156e-06 0.0005712
58 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 37 1142 7.452e-06 0.0005712
59 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 23 541 7.127e-06 0.0005712
60 REGULATION OF PHOSPHORUS METABOLIC PROCESS 47 1618 7.45e-06 0.0005712
61 DEVELOPMENTAL MATURATION 13 193 6.874e-06 0.0005712
62 VASCULATURE DEVELOPMENT 21 469 8.256e-06 0.0006196
63 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 42 1395 1.038e-05 0.0007243
64 NEURON PROJECTION MORPHOGENESIS 19 402 1.054e-05 0.0007243
65 TUBE DEVELOPMENT 23 552 9.867e-06 0.0007243
66 LOCOMOTION 36 1114 1.058e-05 0.0007243
67 RESPONSE TO GROWTH FACTOR 21 475 1.001e-05 0.0007243
68 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 29 801 1.026e-05 0.0007243
69 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 14 232 1.08e-05 0.0007284
70 RESPONSE TO HORMONE 31 893 1.151e-05 0.0007642
71 UROGENITAL SYSTEM DEVELOPMENT 16 299 1.166e-05 0.0007642
72 NEURON PROJECTION GUIDANCE 13 205 1.317e-05 0.0008509
73 CELLULAR COMPONENT MORPHOGENESIS 31 900 1.341e-05 0.0008546
74 REGULATION OF POSTSYNAPTIC MEMBRANE POTENTIAL 7 55 1.672e-05 0.001028
75 CARDIAC MUSCLE CELL ACTION POTENTIAL 6 37 1.64e-05 0.001028
76 POSITIVE REGULATION OF CELL DIFFERENTIATION 29 823 1.7e-05 0.001028
77 RESPONSE TO MECHANICAL STIMULUS 13 210 1.702e-05 0.001028
78 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 27 740 1.833e-05 0.001093
79 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 6 38 1.923e-05 0.001119
80 CENTRAL NERVOUS SYSTEM DEVELOPMENT 30 872 1.903e-05 0.001119
81 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 33 1008 1.959e-05 0.001125
82 CHEMICAL HOMEOSTASIS 30 874 1.987e-05 0.001128
83 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 6 39 2.245e-05 0.001258
84 BONE MORPHOGENESIS 8 79 2.307e-05 0.001278
85 NEURON PROJECTION DEVELOPMENT 22 545 2.507e-05 0.001366
86 RESPONSE TO ESTROGEN 13 218 2.524e-05 0.001366
87 REGULATION OF CELL ADHESION 24 629 2.668e-05 0.001427
88 RESPONSE TO DRUG 19 431 2.768e-05 0.001464
89 REGULATION OF PROTEIN MODIFICATION PROCESS 47 1710 3.078e-05 0.001609
90 REGULATION OF CELL PROJECTION ORGANIZATION 22 558 3.574e-05 0.001831
91 BLOOD VESSEL MORPHOGENESIS 17 364 3.582e-05 0.001831
92 POSITIVE REGULATION OF CELL PROLIFERATION 28 814 3.664e-05 0.001853
93 INTRACELLULAR SIGNAL TRANSDUCTION 44 1572 3.721e-05 0.001862
94 HEART PROCESS 8 85 3.94e-05 0.001934
95 REGULATION OF BLOOD CIRCULATION 15 295 3.948e-05 0.001934
96 RESPONSE TO OXYGEN CONTAINING COMPOUND 40 1381 4.135e-05 0.002004
97 DEVELOPMENTAL GROWTH 16 333 4.333e-05 0.002079
98 GROWTH 18 410 4.748e-05 0.002254
99 TISSUE MORPHOGENESIS 21 533 5.438e-05 0.002503
100 SENSORY ORGAN DEVELOPMENT 20 493 5.486e-05 0.002503
101 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 23 616 5.483e-05 0.002503
102 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 15 303 5.355e-05 0.002503
103 STRIATED MUSCLE CELL DIFFERENTIATION 11 173 5.94e-05 0.002683
104 REGULATION OF MEMBRANE POTENTIAL 16 343 6.156e-05 0.002754
105 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 27 799 6.839e-05 0.003031
106 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORT 6 48 7.545e-05 0.003312
107 RESPONSE TO BMP 8 94 8.118e-05 0.003498
108 CELLULAR RESPONSE TO BMP STIMULUS 8 94 8.118e-05 0.003498
109 REGULATION OF CHEMOTAXIS 11 180 8.492e-05 0.003625
110 REGULATION OF CELL MORPHOGENESIS 21 552 8.924e-05 0.003775
111 MULTICELLULAR ORGANISMAL SIGNALING 9 123 9.572e-05 0.004012
112 METANEPHRIC NEPHRON DEVELOPMENT 5 32 0.0001028 0.004271
113 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 24 689 0.0001106 0.004555
114 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 34 1152 0.0001143 0.004667
115 REGULATION OF METAL ION TRANSPORT 15 325 0.0001172 0.004702
116 POSITIVE REGULATION OF CELL DEATH 22 605 0.0001167 0.004702
117 REGULATION OF HEART CONTRACTION 12 221 0.0001263 0.005002
118 REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 7 75 0.0001269 0.005002
119 MUSCLE CELL DEVELOPMENT 9 128 0.00013 0.005082
120 MESONEPHRIC TUBULE MORPHOGENESIS 6 53 0.0001326 0.005142
121 EMBRYONIC ORGAN DEVELOPMENT 17 406 0.0001363 0.005241
122 RESPONSE TO FLUID SHEAR STRESS 5 34 0.0001386 0.005288
123 RESPONSE TO EXTERNAL STIMULUS 47 1821 0.000141 0.005332
124 CARTILAGE DEVELOPMENT INVOLVED IN ENDOCHONDRAL BONE MORPHOGENESIS 4 19 0.0001569 0.005888
125 RESPONSE TO LIPID 28 888 0.0001617 0.006019
126 BIOLOGICAL ADHESION 31 1032 0.0001706 0.006301
127 DENDRITE DEVELOPMENT 7 79 0.0001761 0.006453
128 CELLULAR RESPONSE TO LIPID 18 457 0.0001861 0.006764
129 BONE GROWTH 4 20 0.0001938 0.006992
130 EXTRACELLULAR STRUCTURE ORGANIZATION 14 304 0.0002015 0.007211
131 HOMEOSTATIC PROCESS 37 1337 0.0002055 0.007301
132 MORPHOGENESIS OF A BRANCHING STRUCTURE 10 167 0.0002095 0.007385
133 NEGATIVE REGULATION OF GENE EXPRESSION 40 1493 0.0002193 0.007671
134 TAXIS 18 464 0.000224 0.007778
135 REGULATION OF ION TRANSPORT 21 592 0.0002332 0.008037
136 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 43 1656 0.0002462 0.008424
137 CHONDROCYTE DIFFERENTIATION 6 60 0.0002651 0.008899
138 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 6 60 0.0002651 0.008899
139 REGULATION OF CELL SIZE 10 172 0.0002658 0.008899
140 TRABECULA MORPHOGENESIS 5 39 0.0002699 0.008972
141 RESPONSE TO ORGANIC CYCLIC COMPOUND 28 917 0.0002733 0.00902
142 REGULATION OF OSTEOBLAST DIFFERENTIATION 8 112 0.0002754 0.009023
143 MUSCLE ORGAN DEVELOPMENT 13 277 0.000282 0.009177
144 MEMBRANE DEPOLARIZATION 6 61 0.0002904 0.00932
145 NEGATIVE REGULATION OF CELL CYCLE 17 433 0.0002904 0.00932
146 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 11 208 0.0003014 0.009604
NumGOOverlapSizeP ValueAdj. P Value
1 VOLTAGE GATED SODIUM CHANNEL ACTIVITY 5 20 9.164e-06 0.008513
NumGOOverlapSizeP ValueAdj. P Value
1 INTRINSIC COMPONENT OF PLASMA MEMBRANE 55 1649 1.135e-08 6.627e-06
2 MEMBRANE MICRODOMAIN 18 288 3.567e-07 0.0001042
3 CONTRACTILE FIBER 14 211 3.631e-06 0.0005301
4 SARCOLEMMA 11 125 2.75e-06 0.0005301
5 I BAND 10 121 1.367e-05 0.001513
6 MEMBRANE REGION 36 1134 1.554e-05 0.001513
7 ACTIN CYTOSKELETON 19 444 4.142e-05 0.003137
8 VOLTAGE GATED SODIUM CHANNEL COMPLEX 4 14 4.298e-05 0.003137
9 BASAL PLASMA MEMBRANE 5 33 0.0001197 0.004993
10 SODIUM CHANNEL COMPLEX 4 17 9.864e-05 0.004993
11 CELL JUNCTION 34 1151 0.0001125 0.004993
12 BASAL PART OF CELL 6 51 0.0001067 0.004993
13 PLASMA MEMBRANE PROTEIN COMPLEX 20 510 8.725e-05 0.004993
14 CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX 5 31 8.781e-05 0.004993
15 CYTOSKELETON 49 1967 0.0002328 0.009062
16 SIDE OF MEMBRANE 17 428 0.0002538 0.009265

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 FoxO_signaling_pathway_hsa04068 11 132 4.682e-06 0.0002435
2 Hippo_signaling_pathway_hsa04390 11 154 2.035e-05 0.0005033
3 Cellular_senescence_hsa04218 11 160 2.904e-05 0.0005033
4 p53_signaling_pathway_hsa04115 7 68 6.771e-05 0.0008802
5 Jak_STAT_signaling_pathway_hsa04630 10 162 0.0001636 0.001701
6 Cytokine_cytokine_receptor_interaction_hsa04060 13 270 0.0002201 0.001908
7 PI3K_Akt_signaling_pathway_hsa04151 14 352 0.0008677 0.006446
8 TGF_beta_signaling_pathway_hsa04350 6 84 0.001598 0.01039
9 TNF_signaling_pathway_hsa04668 6 108 0.0056 0.03236
10 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.008985 0.04672
11 Focal_adhesion_hsa04510 8 199 0.01016 0.04801
12 MAPK_signaling_pathway_hsa04010 10 295 0.01341 0.05809
13 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 6 139 0.018 0.072
14 Adherens_junction_hsa04520 4 72 0.02253 0.08367
15 AMPK_signaling_pathway_hsa04152 5 121 0.03495 0.1104
16 cGMP_PKG_signaling_pathway_hsa04022 6 163 0.03559 0.1104
17 Cell_cycle_hsa04110 5 124 0.03821 0.1104
18 Oocyte_meiosis_hsa04114 5 124 0.03821 0.1104
19 HIF_1_signaling_pathway_hsa04066 4 100 0.06251 0.1711
20 Phospholipase_D_signaling_pathway_hsa04072 5 146 0.0677 0.176
21 Sphingolipid_signaling_pathway_hsa04071 4 118 0.1 0.2477
22 Ferroptosis_hsa04216 2 40 0.1194 0.2795
23 ECM_receptor_interaction_hsa04512 3 82 0.1236 0.2795
24 Ras_signaling_pathway_hsa04014 6 232 0.134 0.2832
25 Calcium_signaling_pathway_hsa04020 5 182 0.1365 0.2832
26 ABC_transporters_hsa02010 2 45 0.1446 0.2832
27 Apelin_signaling_pathway_hsa04371 4 137 0.1485 0.2832
28 Hedgehog_signaling_pathway_hsa04340 2 47 0.155 0.2832
29 Endocytosis_hsa04144 6 244 0.1582 0.2832
30 Cell_adhesion_molecules_.CAMs._hsa04514 4 145 0.1711 0.2832
31 Wnt_signaling_pathway_hsa04310 4 146 0.174 0.2832
32 cAMP_signaling_pathway_hsa04024 5 198 0.1743 0.2832
33 Rap1_signaling_pathway_hsa04015 5 206 0.1945 0.3064
34 VEGF_signaling_pathway_hsa04370 2 59 0.2195 0.3357
35 Tight_junction_hsa04530 4 170 0.2483 0.3689
36 Lysosome_hsa04142 3 123 0.2777 0.4011
37 Autophagy_animal_hsa04140 3 128 0.2979 0.4187
38 Apoptosis_hsa04210 3 138 0.3387 0.4635
39 ErbB_signaling_pathway_hsa04012 2 85 0.3622 0.4797
40 Regulation_of_actin_cytoskeleton_hsa04810 4 208 0.3752 0.4797
41 Gap_junction_hsa04540 2 88 0.3782 0.4797
42 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.4354 0.5357
43 Necroptosis_hsa04217 3 164 0.443 0.5357
44 Neuroactive_ligand_receptor_interaction_hsa04080 4 278 0.5969 0.7054
45 mTOR_signaling_pathway_hsa04150 2 151 0.6608 0.7636

Quest ID: 37d33e6fdc9cd4e0904071ad2a55dd91